#disom

[leedsomics]

Single-cell multi-omics map of human foetal blood in Down's Syndrome

Down's Syndrome (DS) predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood. To understand dysregulated hematopoiesis in DS, we integrated single-cell transcriptomics of over 1.1 million cells with chromatin accessibility and spatial transcriptomics datasets using human foetal liver and bone marrow samples from three disomic and 15 trisomic foetuses. We found that differences in gene expression in DS were both cell type- and environment-dependent. Furthermore, we found multiple lines of evidence that DS haematopoietic stem cells (HSCs) are "primed" to differentiate. We subsequently established a DS-specific map of enhancer-gene relationships in disomic and trisomic HSCs using 10X Multiome data. By integrating this map with genetic variants associated with blood cell variation, we discovered that trisomy restructured enhancer-gene maps to dysregulate enhancer activity and gene expression critical to erythroid lineage differentiation. Further, as DS mutations display a signature of oxidative stress, we validated both increased mitochondrial mass and oxidative stress in DS, and observed that these mutations preferentially fell into regulatory regions of expressed genes in HSCs. Altogether, our single-cell, multi-omic resource provides a high-resolution molecular map of foetal haematopoiesis in Down's Syndrome and indicates significant enhancer-gene restructuring giving rise to co-occurring haematological conditions. http://dlvr.it/SwgGVb

[sagensoren]

//Sagun Sohrai// Siduh Garh Soren Parivar Ren Rusika Koda #sagensoren #sagensoren03 @sagen_soren @sagen_soren03 Jharkhand Disom Super Model Koda #jharkhanddisomsupermodelkoda (at Jharkhand) https://www.instagram.com/p/CnTIn7RPmoQ/?igshid=NGJjMDIxMWI=

[miralwhiz]

El yate fajardo

Findings that increased cerebrospinal fluid levels of proNGF mark the onset of MCI and the transition to AD suggests that this proneurotrophin is a potential disease biomarker. In addition to neurotrophin dysfunction, studies indicate alterations in epigenetically regulated proteins occur within cholinotrophic nbM neurons during the progression of AD, suggesting a mechanism that may underlie changes in transcript expression. Despite these degenerative events the cholinotrophic system is capable of cellular resilience and/or plasticity during the prodromal and later stages of the disease. Data indicate a spatiotemporal pattern of degeneration related to the evolution of tau pathology within cholinotrophic neuronal subgroups located within the nucleus basalis of Meynert (nbM). Both transcript and protein data indicate that cholinotrophic neuronal dysfunction is related to an imbalance between TrkA-mediated survival signaling and the NGF precursor (proNGF)/p75NTR-mediated pro-apoptotic signaling, which may be related to alteration in the metabolism of NGF. The current review summarizes the pathobiology of nerve growth factor (NGF) and its cognate receptors during the progression of Alzheimer’s disease (AD). We demonstrate and validate an interrogative quantitative bioinformatic analysis of a key dysregulated neuronal population linking single population transcript changes to an established pathological hallmark associated with cognitive decline for therapeutic development in human DS and AD. The dysregulated transcriptomic profile of trisomic BFCNs provides key information underscoring selective vulnerability within the septohippocampal circuit.Ĭonclusions: We propose both expected and novel therapeutic targets for DS and AD, including specific DEGs within cholinergic, glutamate, GABAergic, and neurotrophin pathways, as well as select targets for repairing oxidative phosphorylation status in neurons. Leveraging Ingenuity Pathway Analysis and KEGG analysis, we linked differentially expressed gene (DEG) changes within MSN BFCNs to several canonical pathways and aberrant physiological functions. Results: Ts65Dn mice had unique MSN BFCNs transcriptomic profiles at ~6 MO clearly differentiating them from 2N mice. We performed high-throughput, single population RNA sequencing (RNA-seq) to interrogate transcriptomic changes within medial septal nucleus (MSN) BFCNs, using laser capture microdissection to individually isolate ~500 choline acetyltransferase-immunopositive neurons in Ts65Dn and normal disomic (2N) mice at 6 months of age (MO). Methods: We utilized Ts65Dn mice to understand mechanisms underlying BFCN degeneration to identify novel targets for therapeutic intervention. The Ts65Dn trisomic mouse model recapitulates both cognitive and morphological deficits of DS and AD, including BFCN degeneration. Current therapeutics have been unsuccessful in slowing disease progression, likely due to complex pathological interactions and dysregulated pathways that are poorly understood. Background: Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer’s disease (AD).

[phoenixlionme]

Asian Martial Arts

I will be doing a set of posts of all of the martial arts from each of the country they all originated from. I can’t be entirely sure how many martial arts there, so I had to google and went to a site called, wayofthemartialarts.com as well as using Wikipedia on the “List of martial arts” page. If I missed any from this country, please add it but BE polite. I don’t tolerate rudeness. Also, some of these martial arts may include a weapon (s).

1. Bangladesh -> Butthan, Lathi Khela, Boli Khela

2. Cambodia -> Bokator, Pradal Serey

3. China -> Ba Fa; Ba Ji Quan Kung Fu; Ba Gua Zhang; Ba Ji; Bak Mei Kung Fu; Bai Mei; Bao Quan Kung Fu; Bei Tui; Chang Quan; Cha Quan; Chin Na; Choy Gar; Choy Li Fut; Chuo Jiao; DiSom; Di Tang Quan; Drunken Money; Drunken Fist; Duan Quan; Eagle Claw; Emei Quan; Fanzi; Feng Shou; Five Ancestors; Five Animals aka Ng Ying; Fujian White Crane; Guzhuangquan; Fu Jow Pai (Tiger Claw Style); Fut Gar (Buddhist Family); Hei Hu Quan (Black Tiger Fist); Hou Quan Kung Fu; Hua Quan; Hung Fut; Hung Ga; Hung Gar; Jow-Ga Kung Fu; Kunlun Quan; Kuntao; Lai Tung Pai; Lama Pai; Lau Gar; Leopard Style; Liu He Ba Fa; Li Gar Quan (Li Family Fist); Long Quan; Luohan Quan (Arhat Fist); Mei Hua Quan (Plum-blossom Fist); Mian Quan (Cotton Fist); Mi Zong; Mizongyi; Mok Gar; Monkey Style; Nan Quan; Northern Praying Mantis Style; Northern Shaolin; Pao Chui; Pi Gua Quan (Chop-Hanging Fist); Pushing hands; San Da (Chinese Kick-boxing); San Soo; Sanshou; Shaolin Kung Fu; Shuai Jiao (Chinese Wrestling); Shui Quan (Water Fist); Snake Style; Southern Dragon Style; Southern Praying Mantis Style; Tai chi; Tan Tui; Tien Shan Pai; Tong Bei Quan; Wing Chun; Wu Dang Quan; Wushu; Xing Yi Quan; Yau Kung Moon; Yi Quan; Yue Jia Quan; Zi Ran Men; Zui Quan

4. India -> Adimurai; Andhra Pradesh; Bal Vidya; Bihar; Dhanurvidya; Gadayuddha; Gatka; Huyen Langlon; Malla Yuddha; Mushtiyuddha; Kalaripayattu; Karnataka; Kashmir; Kerala; Kick-fighting; Maharashtra; Manipur; Nagaland; Niyuddha; Odisha; Pehlwani; Pugilism; Silambam; Vajra-mushti

5. Indonesia -> Caci; Cakalele; Debus; Fitimaen; Kabasaran; Kuntao; Mekare-kare; Pasola; Payuq; Pencak Silat; Silat; Sisemba; Sitobo Lalang Lipa; Tarung Derajat; Tinju

6. Israel -> Kapap; Krav Maga

7. Iran -> Kung Fu To’a

8. Japan ->  Aikidio; Aikijujitsu; Araki Ryu; Bajutsu; Battojutsu; Bojutsu; Bujutsu; Byakuren Kaikan; Daido Juku Kudo; Daito-Ryu Aikijujutsu; Enshin Kaikan; Goju-Ryu Karate; Hanbojutsu; Hojojutsu; Iaido; Iaijutsu; Isshin-Ryu; Itto-Ryu; Jojutsu; Judo; Jujutsu; Jukendo; Juttejutsu; Karate; Keijojutsu; Kendo; Kenjutsu; Kickboxing; Kobudo; Koryu; Kyokushin Karate; Kyudo; Kyujutsu; Kyusho Jitsu; Naginatajutsu; Ninjutsu; Nippon Kempo; Niten Ichi-Ryu; Nunchaku Jutsu; Shindo Jinen-Ryu; Shintaido; Shito-Ryu Karate; Shootfighing; Shooto; Shorinji Kempo; Shorin-Ryu Karate; Shotokan Karate; Sojutsu; Spochan; Sumo; Taido; Taiho Jutsu;  Tanto Jutsu; Tessenjutsu; Wado-Ryu Karate; Yabusame; Yamanni-Ryu; Yoseikan Budo

9. Korea -> Gongkwon Yusul; Gungdo; Gungsol; Haidong Gumdo; Han Mu Do; Hapkido; Hwa Rang Do; Korean swordsmanhsip; Korean spears; Kuk Sool Won; Kumdo; Kyuk Too Ki; Sibpalki; Soo Bahk Do;  Ssireum; Taekkyeon/Taekkyon; Taekwondo; Tang Soo Do aka Soo Bahk Do; Subak; Teukgong Moosool; Wong Hwa Do; Yongmudo

10. Laos -> Muay Lao

11. Malaysia -> Silat

12. Mongolia -> Bokh aka Mongolian wrestling

13. Myanmar (Burmese) -> Aka; Bando; Banshay; Lethwei; Naban; Pongyi thaing

14. Philippines -> Dumog; Eskrima; Kino Mutai; Panantukan; Sikaran; Yaw Yan

15. Sri Lanka -> Angampora

16. Thailand -> Krabi–krabong; Lerdrit; Muay boran; Muay Thai; Silat Pattani

17. Turkey -> Matrak; Oil Wrestling; Sayokan

18. Vietnam -> Cuong Nhu; Nam Hong Son; Qwan Ki Do; Tam Qui Khi-Kong; Võ thuật Bình Định/Bình Định Gia; Nhất Nam; Võ Việt Nam aka Võ Đạo of Phạm Văn Tan; Vovinam

[hildorien]

I am in the minority but I’d love to know more about the pre-noldor elvish edain culture, history, and just life. 

I wanna know more about men in the context of men, I wanna see history through human eyes without the elvish perspective. 

I wanna know the full experiences of all humans in middle earth not the ones the elves interacted with. And if you have to have elves, I wanna hear about what humans thought of elves that isnt ‘oh they are so perfect and amazing and beautiful uwu’, because that’s kind of boring and we can all agree first age elves? on the whole? pretty shitty. (I love em but they have one brain cell to share among them and fuck up on the regular). 

I wanna see Humans who were born into a dumpster fire that is the world of arda, these are a people who didn’t get Orome leading them to heaven on earth, they got Morgoth. These are a people who lived in Morgoth’s land for centuries who probably experienced horror and oppression from basically their species infancy. Unlike the elves of valinor, or even the Sindarin protected by Melian, horror and despair would have not been their abnormal, it would be their everyday.  But they aren’t broken, they survive. They make families, connections, lives in this wasteland. They adapt and change, because I think in some ways that is the race of men’s true advantage over elves. That we don’t have a gap on our ‘greatness’ persay, humanity’s ambitions get’s mutated into greed a lot (I mean numenor is a dumspter fire for a reason) but I think that human ambition is a strength because it means we don’t accept our circumstances. The Edian sure didn’t. 

The edain, the Boerians, the people of haleth, and the hadorians, all marched themselves out of morgoth’s land hoping for something better, with NO GUARANTEE they find anything better.  But they still did it. And while we are here, let’s talk about how the race of men has not guarantee of anything, like elves (and dwarves) kind of know where they end up. They go to Mandos and get reborn, they go to aule, respectively. Men...don’t have that. Men really didn’t get anything (but Morgoth and suffering). They leave this world forever, thats what they know. Thats what they are told. 

But no one knows what the means. (Personally, I think its like a good place situation kind of. Eru is just michael and turin is janet) 

But anyway back to the POINT, (if there ever was one) the edain end up finding beleriand but beleriand isn’t the paradise they wanted. But hey, its not morgoth so let’s celebrate said the beorians before promptly getting found by finrod. And look elves did a lot of good for humans, but I also think there is this really bad dynamic of elves holding all the power and men just being in it for the ride. 

Ive made the joke that the elves of the first age are kind of like the edian’s sugar daddies but it’s kind of true. They give them land and like ‘wisdom’ (whatever the fuck that means) and in return men give them their ever increasing numbers. The Silm is a very elven story we don’t really get a lot of human, but when we do I think it’s pretty interesting. Because the relationship between Elves and Men is really uneven in the first age...and all ages even though in later ages forces of men like numenor at their height could I think easily sweep the floor with the elves of the second age combined. I think culturally Elves give a lot more, like men end up picking up their language, though im one hundred percent sure human languages didn’t die out and never do, humans must have shit talked elves a LOT in taliska (oh yes, that is the name of at least the language spoken by the hadorians and beorians, the people of haleth spoke a different dialect) and I think a lot of humans give more in resources (aka men, power, infantry). I mean personally if I was having at a guess I don’t think (as the latecomers) men got very many places to actually farm and have good land and relied on elvish goods to survive. I think this unevenness kind of spurred this idea that ‘elvishness = superior’, so to make this full circle I think a lot of pre edain culture was lost to make place for diet pepsi version of elf culture that we see human cultures like numenor and gondor have, because that’s better than their orn because elves are SPECIal BETTER AND DON’T DIE LIKE US BROKEN AND FALLEN PEOPLE.  ((screams)) 

Okay let’s talk about the death thing. Human and Mortal and Men all mean the same thing, humans die is not a statement that should be up for debate. But the humans of edain, at least from what we see of Andreth is that this was not how it always was. Humans were once immortal like the elves until they were bad and listened to morgoth and then they became mortal and all sick and ew. 

yeahhhh, I don’t think thats true. I think in-universe its a great myth. I love finrod ah andreth for this reason (also andreth is tolkien’s best female character he ever created and the fact that she’s not in the published silm is why we are in the bad timeline) , but I think humans...always were mortal. 

And thats okay. 

We talked about human ambition above, I think that is fueled by the fact that we all die. We have a timer, so we have to do things now, and that’s not a bad mindset to have. I think it gets humjans into trouble but also, imagine your a human in beleriand, you have children, a family, they might have children someday you want to do what you need to do to make sure THEY have a chance. 

(also lets talk about the fucked up fact that humans are punished for lsitening to morgoth in the first place like im sorry that humans didnt have any other valar looking for them, there was no orome, no fucking chance that they could have met anyone else because no valar came for them only morgoth with his lies so yes humans are bad for listening to the only god like entity that seemed like he wanted to help them, the elves did that too but they had nice gods so they are wise while humans who have illness and sickness and death over their heads listen to a guy with power okay jirt i see your double fuckig stnarad and its STUPID) 

And you can’t wait for that chance, so you leap. I think this is best illustrated by Turin of all people. Turin gets called elvish a lot in looks but in actions, he, like most of his family, are allllllllll human. The bridge in nargothrand even though it’s stupid and ends up horribly kind of reminds me of this. Turin doesn’t have time to wait like Gwindor, and Orodreth, etc do. his people have already been fucking disomated, he’s lost his father, his mother is trapped in enemy territory.  He wants to help. 

Sure it blows up in his face, but yknow...the want to do good is there. 

I think on the whole humans get a bad rep...like they’re called stupid and dumb and ugly by both fandom and in universe elves alike. But I don’t think that’s the case. Humans have a lot more balls and have collectively been through more trauma as a species than I think all of the elves (especially valinorian) elves combined. I think when humans fuck up, whether it be turin or numenor, it’s proof of their incompetence, that their inante (eru-given ability) to have ambition to seek beyond the world they live in for something better for something more is evil and they should be more like the elves, stagnant, already at the height of ‘perfection’, never changing....instead of being humans. Like look at these fools trying to act like than can be GOOD at something, sit down and let these elves be best at everything obviously. How many of you would look at me funny if I said, maybe the race of men was BETTER THAN THE ELVES AT SOMETHING? A lot of you im sure, and someone would have a rebuttle for how I was wrong and how this elf was considered the best. 

(like that post going around how could turin actually be #that pretty to thot his way through all of beleriand? Maybe he just Was like that, sure he may have a little elvish ness but honestly I think that be a funny thing elves say to cover up the fact some elves found a icky human was actually just that fucking hot, because obviously humans could never be that actually hot ever, not to intangle a sindarin mast of a guard, a NOLDORIAN VANYAR-DESSCENT PRINCESS, ect) 

Also just to go back to numenor, ever want an example of why it doesnt work for men to act like elves...look at numenor, early numenor was as elvish as humans could produce....but then they got bored. And then numneor became an empire and everyone eventually had so much of a bad time, eru reshaped the fucking world just to wipe the valar’s ‘humans but better’ ocs off the face of the planet. Like just to stray off topic I personally think men can’t go to valinor 1) because the two trees are actually nuclear, and the whole damn island is chernobyl instant death right there and thats why the valinor elves are like #that (they GLOW for gods shake) 2) the monotonous never changing perfection of valinor while amazing in the short term for humans would eventually drive them crazy. Not to say that the race of men doesn’t like some peace and quite or even humans (like myself) can be obverse to change, even I can admit doing the same thing ever day would drive me crazy. 

This got super rambly, but its been a lot of thoughts Ive been having for a long ass time. Basically, I just want people to talk to me about the atani, edian, race of men, whatever you want to call them. They deserve a lot better and a lot more respect than just playing a supporting role to the elves. 

They didn’t kill all those dragons to be ignored like this. 

[news4me]

After Owaisi, Mamata Fumes Over Jharkhand Disom Party's 'Efforts' to Boost Tribal Support for BJP in Bengal

After Owaisi, Mamata Fumes Over Jharkhand Disom Party’s ‘Efforts’ to Boost Tribal Support for BJP in Bengal

[ad_1]

Kolkata: A day after slamming Asaduddin Owaisi’s party for dividing the Muslim votes in Bengal, Trinamool Congress chief Mamata Banerjee has now hit out at North Malda administration for failing to control a series of protests taken out by the Jharkhand’s Disom Party (JDP).

During a recent administrative meeting, a visibly angry Mamata came down heavily on the Malda Superintendent of…

[eumeimportocomvc]

"Estes são os filhos de Zibeão: Aías e Anás; este é o Anás que achou as fontes termais no deserto, quando apascentava os jumentos de Zibeão, seu pai. São estes os filhos de Ana: Disom e Aolíbama, filha de Ana. São estes os filhos de Disom: Hendã, Esbã, Itrã e Querã. Estes são os filhos de Eser: Bilã, Zaavã e Acã. Estes são os filhos de Disã: Uz e Arã. Estes são os chefes dos horeus: Lotã, Sobal, Zibeão, Anás, Disom, Eser e Disã; esses são os chefes dos horeus que governaram na terra de Seir. São estes os reis que reinaram na terra de Edom, antes que reinasse rei algum sobre os filhos de Israel. Reinou, pois, em Edom Belá, filho de Beor; e o nome da sua cidade era Dinabá. Morreu Belá; e Jobabe, filho de Zerá de Bozra, reinou em seu lugar. Morreu Jobabe; e Husão, da terra dos temanitas, reinou em seu lugar. " (Gênesis 36:24-34) #NãoBastaSerCristãoTemQuePensar

http://www.facebook.com/pages/p/287488031270711

[ultimateketomealplan]

Education Most Effective Tool for Upliftment of Marginalized Communities: Sisodia

Education Most Effective Tool for Upliftment of Marginalized Communities: Sisodia

Education is the most effective tool for upliftment of marginalized communities Deputy Chief Minister Manish Sisodia Sisodia’s remarks came during his meeting with DISOM fellows from eight states undergoing training in youth leadership and grassroots democracy. PTI Last Updated:May 19, 2022, 11:40 IST FOLLOW US ON: Education is the most effective tool for upliftment of marginalized communities…

[shivamusic-official]

Santhali Song - Sangina Disom | Santhali Video Album : ULAT KACHAR

[suzeblujns]

For just $22.00 Great gift for your favorite electrician! Electrician Belt Buckle Zinc-Alloy with appearance of pewter. 90 g 8.6 cm Oval shape Use with 4 cm belt. Typically arrives within 35 days.

[acharya123himal]

Nepal Digital TV Operators Association of Nepal shaped

Nepal Digital TV Operators Association of Nepal shaped

[ad_1] 2 July, Kathmandu. Nepal Digital TV operators have shaped the Operators Association in Nepal for the primary time. Digital tv. A gathering of digital TV operators has shaped an advert hoc committee aimed toward defending the rights and pursuits of operators and customers.

The ad-hoc committee is headed by Sudip Acharya of Disom and members are Dinesh Subedari (Max TV), Prakash Ghimire…

[flavioricardon]

Workshop de Urgência e Emergência! # Vias aéreas invasivas e não invasivas Foi show demais ! Obrigados aos parceiros : Cts Barreiras Fael Polo Barreiras , GABA , Cotefi , Apolo Pré-vesti , CDI , Ortoclinica ; Disomed . (em Faculdade FAEL Polo Barreiras) https://www.instagram.com/p/B6UC_kij6V_/?igshid=9ls8znjr2gie

[tumbledsom]

After Owaisi, Mamata Fumes Over Jharkhand Disom Party’s ‘Efforts’ to Boost Tribal Support for BJP During a recent administrative meeting, a visibly angry Mamata Banerjee came down heavily on the Police Superintendent for failing to control the rallies by the BJP backed Jharkhand’s Disom Party in Malda North. via Top Politics News- News18.com

[sappharah]

when will my prof stop making assignment questions involving triploids and disomic haploids when i barely understand this shit with normal fucking diploids

[amitbchoudhury]

IPPs dependent on 3rd-party off-take of renewable power at risk as Covid-19 clips disoms’ cash flows: ICRA

IPPs dependent on 3rd-party off-take of renewable power at risk as Covid-19 clips disoms’ cash flows: ICRA

[ad_1]

The renewable energy IPPs (Independent Power Producers) supplying through open access to commercial and industrial consumers face payment risks as cash flows of discoms have been affected due to the Covid-19 lockdown.

States have amended policies over a period and have either completely withdrawn or reduced incentives given to open access consumers as tariff competitiveness of renewable…

[latest-news-pm]

Malda-এ গণবিবাহের অনুষ্ঠানে সংঘর্ষে জোরালো VHP ও Jharkhand Disom Party

#News18Bangla #Malda #JharkhandDisomParty 

 Malda-তে VHP-র গণবিবাহ অনুষ্ঠানে Jharkhand Disom Party -র সংঘর্ষ, লণ্ডভণ্ড অনুষ্ঠান স্থল ।

 #BanglaNews #BengaliNews #বাংলাতাজাখাবার #BengaliNewsLive #বাংলাখবর #News18Bangla

News 18 Bangla is an exclusive news channel on YouTube which streams news related to West Bengal, Nation and the World. The channel also has contemporary topic based debate and subject special series which are interesting & informative. Our channel aims to update the viewers with the current news.

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