#critical breakthrough in research here and the results are sad.

[lakesbian]

also i've been paying attention (no shit) and i've observed that, as of 5.5, alec has been jumping into conversations almost solely to help taylor or try to make a joke with her. it's not that he has no interactions with lisa or brian, but it seems like his dynamics with them are very settled and established: lisa is a roommate he's cool with and a teammate, but they're not the type of people who would make great friends. brian is a casual buddy and someone he could game with, but they're not very close either, and brian is honestly casually shitty to him sometimes. rachel is rachel, and he's not fucking with that. so the fact that, despite being in depressed, dissociative fugues every chapter, he keeps perking up just to be welcoming or helpful to taylor when everyone else has gone silent--the fact that he immediately tries to force "dork" as an affectionate nickname with almost tragic obliviousness to the fact that she doesn't like it--the fact that he keeps trying to start friendly banter with her even when she demonstrably doesn't get it or finds it annoying...it honestly screams of a desperate (and i'm sure entirely unconscious) attempt to try latching onto the first new person who's entered his life in a while, to see if the connection will stick, to see if he can finally become a bit less lonely.

and i think this idea is only strengthened by the fact that we see him do the exact same thing to aisha when she first joins--the example that comes to mind first is when he wraps an arm over her shoulder and jokes about them starting their own team together, but i'm sure i'll find others in the reread. the difference is that, with aisha, it actually works.

alec vasil :( the Loneliest Little Prince...

[ashleyesquierra]

What is STEM?

The acronym STEM, which stands for Science, Technology, Engineering, and Mathematics, is one of the options accessible to students in the Philippines who are allowed to select their SHS journey. It aims to prepare students for a variety of professions, including engineering and academic research as well as careers requiring computational skills and mathematics. Additionally, it is made to help students in senior year develop their curiosity, problem-solving capabilities, and communication ability.

According to the U.S. Bureau of Labor Statistics, some students may already have chosen an option that will help them get ready for their careers in the future and college degrees. Some people are inspired to pursue STEM fields because they genuinely want to learn about natural phenomena, solve complex problems, or develop innovative solutions, while others are motivated by the prospect of having an exciting and lucrative career in engineering and technology. Where in, more students are choosing STEM degrees as of 2023 because these in-demand professions offer job security, high earnings, and opportunities for promotion. Of them, 63%, or over two thirds, pick STEM.

The reasons given by students who do not want to study STEM are that:

a. ) The disciplines are hard or convoluted

b.) They are unrelated to the job path they want to take.

c.) They are not strong at math and computations.

Along with providing students with specialized technical knowledge, STEM education places a strong emphasis on the growth of cooperation, critical thinking, and flexibility. In another area, students who participate in STEM activities may experience a range of emotions, including excitement and curiosity, frustration and sadness, confidence and empowerment, or inspiration and enjoyment. However, learning experiences may boost students' confidence and self-esteem as they successfully overcome obstacles and pick up new skills.

To successfully establish the STEM strand, here is a list of specialized subjects in the Science, Technology, Engineering, and Mathematics (STEM) strand.

CORE SUBJECT:

• Oral Communication

• Komunikasyon at Pananaliksik sa Wika at Kulturang Pilipino

• General Mathematics

• Statistics & Probability 

• Philosophy

• Physical Education & Health

• Disaster Readiness and Risk Reduction

• Understanding Culture, Society, and Politics

SPECIALIZED SUBJECT:

• Pre & Basic Calculus

• General Chemistry

• General Physics 

• General Biology

• Research Project

CONTEXTUALIZED SUBJECT

• Empowerment Technologies 

• Practical Research

• English for Academic and Professional Purposes 

• Entrepreneurship 

Compared to other SHS strands, the STEM strand includes a wide range of subjects. The students are thus exposed to an abundance of concepts and ideas that they can apply to their daily life as well as in their future studies. With that, Here are the benefits of learning STEM education after graduating with this strand, according to Transizion.

1. Growing Career Field

This means that in addition to earning a respectable wage, you'll also probably have an easier time getting work.

2. Ability to impact society using your stem degree

Individuals led by professionals in STEM fields frequently advance computer technology or produce ground-breaking medical breakthroughs.

3. Flexibility

STEM majors open up a variety of job choices, from computer science to engineering. STEM majors can switch occupations with ease since these skills, which are based in arithmetic and problem-solving, are adaptable.

4. Diversity

As a result, women and people of other racial and cultural backgrounds have more opportunity to pursue STEM degrees, and STEM graduates benefit from a rich and diverse environment for employment and education.

The STEM strand opens up a variety of options for SHS students in the Philippines, enabling them to enroll in programs including engineering, technology-related fields, and medical sciences. Students develop key problem-solving abilities that are crucial for what lies ahead in education through in-depth classes and assignments. Students' perspectives in the dynamic disciplines of science, technology, engineering, and mathematics are expanded by this strand, which serves as a foundational stepping stone.

REFERENCE:

[timclymer]

Breast Cancer Genes: Preventative Chemotherapy – Is It Really A Game-Changing Breakthrough?

The British media has seen a flurry of excitement since the National Institute of Health and Care Excellence (NICE) published guidelines on 25th June 2013, announcing that “Women with a family history of the disease will be able to get tamoxifen and raloxifene on the NHS” (Independent newspaper, UK, 25 June 2013)

My heart dropped like a stone when I heard that a ‘daily pill’ is being labelled a ” ‘game-changing’ breakthrough in preventive care” (Independent) by campaigners and breast cancer experts in the field. I am not a medical practitioner or researcher. I am a woman who’s life has been changed by a breast cancer diagnosis and subsequent genetics testing at a young age. Pro-choice for every person affected by cancer, I applaud any new treatment or research which may help people to avoid a diagnosis of cancer – or in this case, breast cancer. However, the idea that a daily pill could be lauded as clinical excellence fills me with unease. For in the cold light of day, these guidelines are promoting a daily dispensation of hormone therapy, which to all intents and purposes is a form of chemo-therapy, that is unable to offer more than a 50% possibility that it may protect the patient from a breast cancer diagnosis.

Judith Potts wrote a very interesting article for the Telegraph in April 2013 (Telegraph, UK – Tamoxifen: it is staggering how much research into this drug is taking place), where she shared her personal experiences of using Tamoxifen as part of her breast cancer treatment protocol and about research undertaken in the US, on which NICE’s guidelines appear to have been based upon, according to media reports.

Life is all about making choices. However, what happens when it is difficult to gather up all the information we need to make fully-informed choices? Most critically, at a time when our emotions and sense of reasoning may be in tatters?

On 26th June I was invited to be interviewed live on a prominent news show. The show’s researcher seemed taken aback that I was not cheering loudly from the sidelines. Instead, I was invited to share my point of view that – just as genetics testing is not an easy option – neither should we look to a form of hormone (chemical) therapy to be the great bringer of hope to those who are sadly affected by the BRAC1/BRAC2 genetic anomalies. Just as prophylactic mastectomies may not be the overall answer, neither should prophylactic chemo-therapy be seen as an ‘hallelujah’ option. People with these life-changing results really need – and deserve – to be informed of every option available to them. Natural and alternative therapies, as well as orthodox treatments. They should then be given as much time as is practically possible to research their options, perhaps also speaking to people who have walked on the same path before them, and make a decision based on what ‘feels’ the right course of action as an individual.

As Audre Lorde wisely said: ‘Our feelings are our most genuine paths to knowledge’.

Time after time, I feel infuriated and saddened that the ‘breast cancer’ tag is bandied about rather carelessly by the mainstream media, inducing fear into the population. For the sad reality is, therecannot be many people who’s lives have not been touched by the spectre of breast cancer over the years. Angelina Jolie’s brave decision – which I believe was the perfect option for her, as an individual – a few weeks ago saw a rush of terrified women beseeching their medical practitioners to send them for genetics testing, which is a long, drawn-out process and which can be emotional torture. I certainly felt under immense emotional strain whilst awaiting my results.

No longer am I fervently opposed to orthodox medicine, a ‘New-Age’ type who believes cancer must be treated with – and ONLY with – natural methods and emotional healing. Being diagnosed with Triple Negative breast cancer just two short years ago – which Tamoxifen would have been utterly useless in stopping, as it targets oestrogen-receptive breast cancer tumours only – saw me signing up for the whole orthodox medical treatment protocol, supplemented by natural and alternative therapies. My life was undeniably saved by these invasive treatments and I choose to see the daily side-effects I am left with as a daily reminder to give blessings, for I owe my life to modern-day medicine.

There are always underlying reasons for any illness which presents in us, such as environmental toxins, stressors, poor diet, ‘buried’ emotions – which, if addressed and treated sympathetically, will bring our bodies back to balance and natural harmony. We could all do with am emotional spring clean every year, thereby lessening the opportunity for awry-cells to start buddying-up and cause chaos by evolving into illnesses or tumours, for example.

My dearest wish would be for a fully-integrated resource to be set-up, bringing together the very best of clinical practices and protocols by world leaders, supplemented and supported by tools and wisdom from pioneers such as the Penny Brohn Cancer Centre and CancerActive. A “one-stop educational resource centre” where we could unravel the medical jargon and humanise all the options available to us, where we can listen to our inner wisdom and choose the best options available for us as individuals.

Another key aspect of the educational process, I feel, is for charities in the UK such as BosomBuddiesUK and CoppaFeel to work with schools and women under the age of 25 to promote the importance of knowing their bodies and checking their breasts regularly, also reaching out to males as part of preventative measures. We must ensure our younger generations take a proactive role in health care, not the default ‘reactive’ role we seem to muddle along with here in the UK, with an evident lack of self-responsibility in taking good care of ourselves. Yes, I have been just as guilty of that, too!

If the researchers are still not clear about exactly how tamoxifen blocks tumours from growing, then what else are we not aware of with respect to this type of hormone therapy and it’s side-effects. Six years of research form the basis of the NICE guidelines, yet they predict the drug may only offer protection for only ten years… ah, it’s not enough for me. I will stick with the blend of orthodox, alternative and natural methods that seem to be (I pray) working – give me frankincense and lemon essential oils, along with joyful healthy living any day of the week.

Can hormone treatment subsidised by the NHS provide a game-changing breakthrough in Breast Cancer preventative care? If only it were. Research and clinical excellence must continue to work together and work together with natural and alternative therapies to provide an integrated preventative health plan which will focus more upon living harmoniously with ourselves.

Stay safe, stay aware and be open to all options – but most of all, I invite you to tune in to your body and follow the courage of your own convictions.

Source by Callie Carling

from Home Solutions Forev https://homesolutionsforev.com/breast-cancer-genes-preventative-chemotherapy-is-it-really-a-game-changing-breakthrough/ via Home Solutions on WordPress from Home Solutions FOREV https://homesolutionsforev.tumblr.com/post/187058570580 via Tim Clymer on Wordpress

[homesolutionsforev]

Breast Cancer Genes: Preventative Chemotherapy – Is It Really A Game-Changing Breakthrough?

The British media has seen a flurry of excitement since the National Institute of Health and Care Excellence (NICE) published guidelines on 25th June 2013, announcing that “Women with a family history of the disease will be able to get tamoxifen and raloxifene on the NHS” (Independent newspaper, UK, 25 June 2013)

My heart dropped like a stone when I heard that a ‘daily pill’ is being labelled a ” ‘game-changing’ breakthrough in preventive care” (Independent) by campaigners and breast cancer experts in the field. I am not a medical practitioner or researcher. I am a woman who’s life has been changed by a breast cancer diagnosis and subsequent genetics testing at a young age. Pro-choice for every person affected by cancer, I applaud any new treatment or research which may help people to avoid a diagnosis of cancer – or in this case, breast cancer. However, the idea that a daily pill could be lauded as clinical excellence fills me with unease. For in the cold light of day, these guidelines are promoting a daily dispensation of hormone therapy, which to all intents and purposes is a form of chemo-therapy, that is unable to offer more than a 50% possibility that it may protect the patient from a breast cancer diagnosis.

Judith Potts wrote a very interesting article for the Telegraph in April 2013 (Telegraph, UK – Tamoxifen: it is staggering how much research into this drug is taking place), where she shared her personal experiences of using Tamoxifen as part of her breast cancer treatment protocol and about research undertaken in the US, on which NICE’s guidelines appear to have been based upon, according to media reports.

Life is all about making choices. However, what happens when it is difficult to gather up all the information we need to make fully-informed choices? Most critically, at a time when our emotions and sense of reasoning may be in tatters?

On 26th June I was invited to be interviewed live on a prominent news show. The show’s researcher seemed taken aback that I was not cheering loudly from the sidelines. Instead, I was invited to share my point of view that – just as genetics testing is not an easy option – neither should we look to a form of hormone (chemical) therapy to be the great bringer of hope to those who are sadly affected by the BRAC1/BRAC2 genetic anomalies. Just as prophylactic mastectomies may not be the overall answer, neither should prophylactic chemo-therapy be seen as an ‘hallelujah’ option. People with these life-changing results really need – and deserve – to be informed of every option available to them. Natural and alternative therapies, as well as orthodox treatments. They should then be given as much time as is practically possible to research their options, perhaps also speaking to people who have walked on the same path before them, and make a decision based on what ‘feels’ the right course of action as an individual.

As Audre Lorde wisely said: ‘Our feelings are our most genuine paths to knowledge’.

Time after time, I feel infuriated and saddened that the ‘breast cancer’ tag is bandied about rather carelessly by the mainstream media, inducing fear into the population. For the sad reality is, therecannot be many people who’s lives have not been touched by the spectre of breast cancer over the years. Angelina Jolie’s brave decision – which I believe was the perfect option for her, as an individual – a few weeks ago saw a rush of terrified women beseeching their medical practitioners to send them for genetics testing, which is a long, drawn-out process and which can be emotional torture. I certainly felt under immense emotional strain whilst awaiting my results.

No longer am I fervently opposed to orthodox medicine, a ‘New-Age’ type who believes cancer must be treated with – and ONLY with – natural methods and emotional healing. Being diagnosed with Triple Negative breast cancer just two short years ago – which Tamoxifen would have been utterly useless in stopping, as it targets oestrogen-receptive breast cancer tumours only – saw me signing up for the whole orthodox medical treatment protocol, supplemented by natural and alternative therapies. My life was undeniably saved by these invasive treatments and I choose to see the daily side-effects I am left with as a daily reminder to give blessings, for I owe my life to modern-day medicine.

There are always underlying reasons for any illness which presents in us, such as environmental toxins, stressors, poor diet, ‘buried’ emotions – which, if addressed and treated sympathetically, will bring our bodies back to balance and natural harmony. We could all do with am emotional spring clean every year, thereby lessening the opportunity for awry-cells to start buddying-up and cause chaos by evolving into illnesses or tumours, for example.

My dearest wish would be for a fully-integrated resource to be set-up, bringing together the very best of clinical practices and protocols by world leaders, supplemented and supported by tools and wisdom from pioneers such as the Penny Brohn Cancer Centre and CancerActive. A “one-stop educational resource centre” where we could unravel the medical jargon and humanise all the options available to us, where we can listen to our inner wisdom and choose the best options available for us as individuals.

Another key aspect of the educational process, I feel, is for charities in the UK such as BosomBuddiesUK and CoppaFeel to work with schools and women under the age of 25 to promote the importance of knowing their bodies and checking their breasts regularly, also reaching out to males as part of preventative measures. We must ensure our younger generations take a proactive role in health care, not the default ‘reactive’ role we seem to muddle along with here in the UK, with an evident lack of self-responsibility in taking good care of ourselves. Yes, I have been just as guilty of that, too!

If the researchers are still not clear about exactly how tamoxifen blocks tumours from growing, then what else are we not aware of with respect to this type of hormone therapy and it’s side-effects. Six years of research form the basis of the NICE guidelines, yet they predict the drug may only offer protection for only ten years… ah, it’s not enough for me. I will stick with the blend of orthodox, alternative and natural methods that seem to be (I pray) working – give me frankincense and lemon essential oils, along with joyful healthy living any day of the week.

Can hormone treatment subsidised by the NHS provide a game-changing breakthrough in Breast Cancer preventative care? If only it were. Research and clinical excellence must continue to work together and work together with natural and alternative therapies to provide an integrated preventative health plan which will focus more upon living harmoniously with ourselves.

Stay safe, stay aware and be open to all options – but most of all, I invite you to tune in to your body and follow the courage of your own convictions.

Source by Callie Carling

from Home Solutions Forev https://homesolutionsforev.com/breast-cancer-genes-preventative-chemotherapy-is-it-really-a-game-changing-breakthrough/ via Home Solutions on WordPress

[skylight20sworldblr-blog]

10 Uplifting Stories To Get You Through The Week (1/20/19)

To enable you to finish the week on a constructive observe, we’ve got gathered into one record all of the information which may raise your spirits. That is the place you’ll discover a good mixture of feel-good tales mixed with vital achievements and tales of true togetherness. For those who want one thing bizarre and wacky, take a look at the offbeat record.

This week, we study that the world’s loneliest frog has discovered a girlfriend. A pet has a miraculous survival, and a person’s life is saved by beer. There are a couple of probably “game-changing” medical breakthroughs, an excessive feat of endurance, and a humbling act of forgiveness.

10 Courtroom Clemency

The sufferer of a DUI hit surprised the courtroom when she not solely forgave her attacker but in addition requested for his assist.

Three and a half years in the past, Montreal lady Tina Adams went out for a jog and was hit by 22-year-old Jordan Taylor, who was drunk behind the wheel. Nineteen surgical procedures later, Tina was capable of overcome the fractured backbone, cracked cranium, mind damage, and blood clots she suffered within the crash.

She might have survived, however Adams will cope with ache for the remainder of her life. She will not turn out to be a police officer due to her accidents and should not be capable of have youngsters. Within the years because the crash, Tina has traveled to colleges to speak about her expertise and to warn college students of the risks of drunk driving.

She stunned everybody when she requested Taylor to hitch her on these faculty talks throughout his sentencing listening to.[1] Tina believes that having the man who hit her there could have a huge effect on the scholars. She had considered doing this for some time however needed to attend till assembly him in courtroom to see if he confirmed real regret.

9 Romeo Finds His Juliet

A lonely male frog as soon as considered the final of his variety lastly has a associate after a decade of solitude.

Romeo is a Sehuencas water frog. Ten years in the past, conservationists realized that the species was in hassle in order that they collected him from the wild to put him right into a breeding program. Nevertheless, they couldn’t discover a feminine appropriate for him. Romeo was left in isolation in a Bolivian aquarium.

Now he’s not alone. A current expedition into the wilderness of Bolivia turned up 5 new Sehuencas water frogs—three males and two females. Certainly one of them, named Juliet, shall be positioned with Romeo within the hopes that they’ll breed collectively. In the intervening time, all the brand new amphibians are nonetheless in quarantine.

Herpetologists are hoping that opposites will appeal to when the 2 lastly meet. Their personalities appear to be antithetical to one another. Whereas Romeo is calm, sluggish, and doesn’t transfer round quite a bit, Juliet could be very lively, swims always, and eats every part in sight.[2]

eight The Chief And The Good Samaritan

Final Saturday, the Kansas Metropolis Chiefs scored a playoff victory over the Indianapolis Colts and made their solution to the AFC Championship Recreation later in the present day. Nevertheless, issues may need turned out in another way have been it not for a Good Samaritan who stopped to lend a serving to hand.

Hours earlier than the sport was set to start out at Arrowhead Stadium in Kansas Metropolis, Missouri, Chiefs offensive lineman Jeff Allen was caught within the snow. He in all probability would have missed the match if Dave Cochran hadn’t pulled over in his truck and helped Allen transfer his car.

Because it later turned out, Cochran was homeless and dwelling in his truck. Nevertheless, that didn’t cease him from aiding different individuals, which he thought-about his “natural habit.” When he pulled over, he didn’t know he was coping with a Kansas Metropolis Chiefs participant. He noticed somebody with Texas plates on his automotive and figured that he in all probability wasn’t used to driving in snowy circumstances.

Allen was eager to return the favor and took to Twitter the subsequent day to succeed in out to Cochran. Inside a couple of hours, he was capable of contact his snowy savior and provides him a few tickets to the AFC Championship Recreation. Cochran admitted that he was solely anticipating a “thank you” however that Allen’s gesture is “like a dream come true.”[3]

7 A New Remedy

In accordance with a brand new research revealed within the journal Most cancers Cell, Swiss researchers from the College of Basel are engaged on a revolutionary new remedy which may change breast most cancers cells into innocent fats cells.

Most cancers cells can bear a course of referred to as epithelial-mesenchymal transition (EMT). Usually, that is one thing that makes them extremely harmful because it permits them to unfold to different kinds of cells within the physique. Nevertheless, scientists consider that the identical mechanism can be utilized towards them.[4]

Throughout an experiment, researchers injected feminine mice with an aggressive type of feminine breast most cancers. When the cells began present process EMT, the scientists additionally injected an antidiabetic drug referred to as rosiglitazone and a most cancers inhibitor named trametinib.

The mixed remedy not solely turned the most cancers cells into fats cells but in addition stopped them from proliferating. Furthermore, lead writer Gerhard Christofori believes that the remedy may have a shorter, simpler path to human trials as a result of the medicine concerned are already permitted.

6 50,000 Cures For Loneliness

Together with his birthday approaching, World Struggle II navy veteran Duane Sherman was feeling a bit lonely. His daughter requested associates on Fb if they might ship him some well-wishes. He acquired over 50,000 letters.

In the meanwhile, there are birthday playing cards, thanks notes, small presents, and mementos filling postal bins stacked one on prime of one other all all through Sherman’s residence in Fullerton, California. And that solely represents a fraction of the whole. He needed to retailer hundreds of letters at a pal’s home, and lots of extra bins are nonetheless ready to be picked up on the submit workplace.[5]

He has acquired letters from all 50 states and 10 totally different nations. A number of the senders included the Pittsburgh Steelers and the Secretary of the Navy. The commander of the united statesCowpens even took the vet out to lunch whereas officers from the San Diego US Navy Sonar Faculty paid him a go to to take heed to his tales.

Sherman’s birthday was on December 30, and up to now, he has gone by means of fewer than 2,000 letters. He’s legally blind, so his daughter, Sue Morse, has to learn them to him. It’s fairly protected to say that they are going to be busy for the foreseeable future.

5 How To Get Over A Case Of The Mondays

Tomorrow is Blue Monday, thought-about to be probably the most depressing day of the yr. However is there any fact to this, and are there methods of getting via the day with a smile in your face?

Proper off the bat, should you reside within the southern hemisphere, you’re off the hook. The chilly climate is among the essential elements which contribute to the distress.

The idea of “Blue Monday” got here from UK psychologist Cliff Arnall in 2005. It often falls on the third Monday of the yr. Arnall claims to have developed an equation to find out the saddest day utilizing elements comparable to climate, debt degree, time handed because the holidays, and time handed since individuals broke their New Yr’s resolutions.[6]

The entire factor was truly devised for an advert marketing campaign for trip firm Sky Journey. It has been often dismissed as pseudoscience. Even Arnall admitted that he by no means meant to make the day sound unfavourable however to encourage individuals to take motion.

Let’s say you feel down within the dumps. Even when Blue Monday is a fantasy, seasonal affective dysfunction (SAD) is actual. If you wish to raise your spirits, psychologists advocate a little bit of train, a pleasant stroll outdoors, and enjoyable, difficult indoor actions.

A more healthy weight loss plan wealthy in good fat and antioxidants can even assist to stop melancholy. There’s even mild remedy utilizing particular SAD lamps to make up for all that daylight you’re lacking throughout winter.

four Pet Drop Has Joyful Ending

A tiny pet miraculously survived a drop from the sky with no critical accidents after being kidnapped by a hawk.

Final Saturday, development staff in Austin, Texas, responded to cries belonging to a Chihuahua pooch which weighed lower than zero.5 kilograms (1 lb). Questioning how the canine obtained there within the first place, they seemed up and noticed a hawk circling above. They realized that the raptor had picked up the pet and dropped it from the air.

The staff took the canine to the Austin Animal Middle the place vets have been stunned to find that the animal had solely delicate accidents and no damaged bones. The worst of the bunch have been the puncture wounds brought on by the hawk’s talons, however even these will heal up utterly in due time. The pet, now referred to as Tony Hawk, is resting together with his foster household and can discover a everlasting house in a couple of weeks.[7]

three A Recreation-Altering Transplant

Medical specialists are hailing a brand new process for liver transplants as a “game-changer” which can halve the ready listing.

Proper now, a few third of all donated livers by no means make it right into a affected person. On the similar time, 20 % of individuals in want of a brand new liver die on the ready record. That is because of the regular storage technique which makes use of ice. It causes the organ to deteriorate, and there’s solely a restricted time to transplant it earlier than it turns into unusable.

A brand new remedy makes use of normothermic perfusion machines to protect the liver. They continually pump the organ with oxygenated blood and vitamins at physique temperature in order that it may be saved for longer durations of time with no sick results.[8]

Furthermore, the blood remedy can truly be used to restore livers which have been broken throughout removing or have come from aged or sick donors. Subsequently, they permit docs to make use of organs which in any other case would have been discarded.

2 A Shattering Efficiency

New mom Jasmin Paris gained the Montane Backbone Race alongside the Pennine Approach within the UK, smashing the earlier document by over 12 hours.

The 431-kilometer (268 mi) race is likely one of the most grueling endurance challenges in Europe. Runners go from Derbyshire to the Scottish border, spending round two-thirds of their trek at the hours of darkness.

They cowl a variety of hilly terrain and should climb over 13,000 meters (43,000 ft) in complete. They’ve to hold their very own package and provides and may’t have a help workforce or runner be a part of them on the course. Rivals carry an emergency button in case they’re not capable of stroll.

With a time of 83 hours, 12 minutes, and 23 seconds, Paris turned the primary lady to win the race and had the quickest time ever—by far. The earlier document of 95 hours and 17 minutes was set in 2016 by Eoin Keith.

Just some checkpoints are allowed in the course of the race, and Paris slept for less than three hours throughout the entire thing. She admitted that she had begun hallucinating by the final day. She noticed animals seem out of nowhere and timber doing morning stretches.[9]

1 Beer Saves Life

Beer might be good for you, and 48-year-old Vietnamese man Nguyen Van Nhat is proof of that. When he got here into the hospital unconscious, affected by methanol poisoning, docs pumped him with 15 cans of beer and saved his life.

Methanol is a type of alcohol. However it’s a very poisonous one which is usually present in paints, thinners, cleansing merchandise, and antifreeze slightly than drinks. Business spirit producers take additional steps to take away methanol from their merchandise, though it could possibly nonetheless be present in harmful portions in bootleg liquor.

The supply of the methanol consumed by Nguyen Van Nhat is unknown, however he had over 1,000 occasions the really helpful restrict. Docs knew that he would die if his liver processed all of the methanol in his system. The liver converts the alcohol into formaldehyde which is then damaged down into formic acid. Docs have been in search of a method to decelerate the method, they usually discovered it with beer.

Beer accommodates one other sort of alcohol referred to as ethanol. It’s the alcohol present in most shopper drinks on the planet. Though it’s nonetheless poisonous, its results are far milder. Because it occurs, the liver first processes ethanol and solely afterward strikes as much as methanol.

Subsequently, so long as there was beer in Nguyen Van Nhat’s system, his physique wouldn’t be broken by the methanol. Docs transfused 15 cans value of beer into the affected person at a fee of a can per hour, thus giving the dialysis sufficient time to take away the methanol from his system.[10]

The post 10 Uplifting Stories To Get You Through The Week (1/20/19) appeared first on List Technology.

[aethermystfan-blog]

10 Uplifting Stories To Get You Through The Week (1/20/19)

To enable you to finish the week on a constructive observe, we’ve got gathered into one record all of the information which may raise your spirits. That is the place you’ll discover a good mixture of feel-good tales mixed with vital achievements and tales of true togetherness. For those who want one thing bizarre and wacky, take a look at the offbeat record.

This week, we study that the world’s loneliest frog has discovered a girlfriend. A pet has a miraculous survival, and a person’s life is saved by beer. There are a couple of probably “game-changing” medical breakthroughs, an excessive feat of endurance, and a humbling act of forgiveness.

10 Courtroom Clemency

The sufferer of a DUI hit surprised the courtroom when she not solely forgave her attacker but in addition requested for his assist.

Three and a half years in the past, Montreal lady Tina Adams went out for a jog and was hit by 22-year-old Jordan Taylor, who was drunk behind the wheel. Nineteen surgical procedures later, Tina was capable of overcome the fractured backbone, cracked cranium, mind damage, and blood clots she suffered within the crash.

She might have survived, however Adams will cope with ache for the remainder of her life. She will not turn out to be a police officer due to her accidents and should not be capable of have youngsters. Within the years because the crash, Tina has traveled to colleges to speak about her expertise and to warn college students of the risks of drunk driving.

She stunned everybody when she requested Taylor to hitch her on these faculty talks throughout his sentencing listening to.[1] Tina believes that having the man who hit her there could have a huge effect on the scholars. She had considered doing this for some time however needed to attend till assembly him in courtroom to see if he confirmed real regret.

9 Romeo Finds His Juliet

A lonely male frog as soon as considered the final of his variety lastly has a associate after a decade of solitude.

Romeo is a Sehuencas water frog. Ten years in the past, conservationists realized that the species was in hassle in order that they collected him from the wild to put him right into a breeding program. Nevertheless, they couldn’t discover a feminine appropriate for him. Romeo was left in isolation in a Bolivian aquarium.

Now he’s not alone. A current expedition into the wilderness of Bolivia turned up 5 new Sehuencas water frogs—three males and two females. Certainly one of them, named Juliet, shall be positioned with Romeo within the hopes that they’ll breed collectively. In the intervening time, all the brand new amphibians are nonetheless in quarantine.

Herpetologists are hoping that opposites will appeal to when the 2 lastly meet. Their personalities appear to be antithetical to one another. Whereas Romeo is calm, sluggish, and doesn’t transfer round quite a bit, Juliet could be very lively, swims always, and eats every part in sight.[2]

eight The Chief And The Good Samaritan

Final Saturday, the Kansas Metropolis Chiefs scored a playoff victory over the Indianapolis Colts and made their solution to the AFC Championship Recreation later in the present day. Nevertheless, issues may need turned out in another way have been it not for a Good Samaritan who stopped to lend a serving to hand.

Hours earlier than the sport was set to start out at Arrowhead Stadium in Kansas Metropolis, Missouri, Chiefs offensive lineman Jeff Allen was caught within the snow. He in all probability would have missed the match if Dave Cochran hadn’t pulled over in his truck and helped Allen transfer his car.

Because it later turned out, Cochran was homeless and dwelling in his truck. Nevertheless, that didn’t cease him from aiding different individuals, which he thought-about his “natural habit.” When he pulled over, he didn’t know he was coping with a Kansas Metropolis Chiefs participant. He noticed somebody with Texas plates on his automotive and figured that he in all probability wasn’t used to driving in snowy circumstances.

Allen was eager to return the favor and took to Twitter the subsequent day to succeed in out to Cochran. Inside a couple of hours, he was capable of contact his snowy savior and provides him a few tickets to the AFC Championship Recreation. Cochran admitted that he was solely anticipating a “thank you” however that Allen’s gesture is “like a dream come true.”[3]

7 A New Remedy

In accordance with a brand new research revealed within the journal Most cancers Cell, Swiss researchers from the College of Basel are engaged on a revolutionary new remedy which may change breast most cancers cells into innocent fats cells.

Most cancers cells can bear a course of referred to as epithelial-mesenchymal transition (EMT). Usually, that is one thing that makes them extremely harmful because it permits them to unfold to different kinds of cells within the physique. Nevertheless, scientists consider that the identical mechanism can be utilized towards them.[4]

Throughout an experiment, researchers injected feminine mice with an aggressive type of feminine breast most cancers. When the cells began present process EMT, the scientists additionally injected an antidiabetic drug referred to as rosiglitazone and a most cancers inhibitor named trametinib.

The mixed remedy not solely turned the most cancers cells into fats cells but in addition stopped them from proliferating. Furthermore, lead writer Gerhard Christofori believes that the remedy may have a shorter, simpler path to human trials as a result of the medicine concerned are already permitted.

6 50,000 Cures For Loneliness

Together with his birthday approaching, World Struggle II navy veteran Duane Sherman was feeling a bit lonely. His daughter requested associates on Fb if they might ship him some well-wishes. He acquired over 50,000 letters.

In the meanwhile, there are birthday playing cards, thanks notes, small presents, and mementos filling postal bins stacked one on prime of one other all all through Sherman’s residence in Fullerton, California. And that solely represents a fraction of the whole. He needed to retailer hundreds of letters at a pal’s home, and lots of extra bins are nonetheless ready to be picked up on the submit workplace.[5]

He has acquired letters from all 50 states and 10 totally different nations. A number of the senders included the Pittsburgh Steelers and the Secretary of the Navy. The commander of the united statesCowpens even took the vet out to lunch whereas officers from the San Diego US Navy Sonar Faculty paid him a go to to take heed to his tales.

Sherman’s birthday was on December 30, and up to now, he has gone by means of fewer than 2,000 letters. He’s legally blind, so his daughter, Sue Morse, has to learn them to him. It’s fairly protected to say that they are going to be busy for the foreseeable future.

5 How To Get Over A Case Of The Mondays

Tomorrow is Blue Monday, thought-about to be probably the most depressing day of the yr. However is there any fact to this, and are there methods of getting via the day with a smile in your face?

Proper off the bat, should you reside within the southern hemisphere, you’re off the hook. The chilly climate is among the essential elements which contribute to the distress.

The idea of “Blue Monday” got here from UK psychologist Cliff Arnall in 2005. It often falls on the third Monday of the yr. Arnall claims to have developed an equation to find out the saddest day utilizing elements comparable to climate, debt degree, time handed because the holidays, and time handed since individuals broke their New Yr’s resolutions.[6]

The entire factor was truly devised for an advert marketing campaign for trip firm Sky Journey. It has been often dismissed as pseudoscience. Even Arnall admitted that he by no means meant to make the day sound unfavourable however to encourage individuals to take motion.

Let’s say you feel down within the dumps. Even when Blue Monday is a fantasy, seasonal affective dysfunction (SAD) is actual. If you wish to raise your spirits, psychologists advocate a little bit of train, a pleasant stroll outdoors, and enjoyable, difficult indoor actions.

A more healthy weight loss plan wealthy in good fat and antioxidants can even assist to stop melancholy. There’s even mild remedy utilizing particular SAD lamps to make up for all that daylight you’re lacking throughout winter.

four Pet Drop Has Joyful Ending

A tiny pet miraculously survived a drop from the sky with no critical accidents after being kidnapped by a hawk.

Final Saturday, development staff in Austin, Texas, responded to cries belonging to a Chihuahua pooch which weighed lower than zero.5 kilograms (1 lb). Questioning how the canine obtained there within the first place, they seemed up and noticed a hawk circling above. They realized that the raptor had picked up the pet and dropped it from the air.

The staff took the canine to the Austin Animal Middle the place vets have been stunned to find that the animal had solely delicate accidents and no damaged bones. The worst of the bunch have been the puncture wounds brought on by the hawk’s talons, however even these will heal up utterly in due time. The pet, now referred to as Tony Hawk, is resting together with his foster household and can discover a everlasting house in a couple of weeks.[7]

three A Recreation-Altering Transplant

Medical specialists are hailing a brand new process for liver transplants as a “game-changer” which can halve the ready listing.

Proper now, a few third of all donated livers by no means make it right into a affected person. On the similar time, 20 % of individuals in want of a brand new liver die on the ready record. That is because of the regular storage technique which makes use of ice. It causes the organ to deteriorate, and there’s solely a restricted time to transplant it earlier than it turns into unusable.

A brand new remedy makes use of normothermic perfusion machines to protect the liver. They continually pump the organ with oxygenated blood and vitamins at physique temperature in order that it may be saved for longer durations of time with no sick results.[8]

Furthermore, the blood remedy can truly be used to restore livers which have been broken throughout removing or have come from aged or sick donors. Subsequently, they permit docs to make use of organs which in any other case would have been discarded.

2 A Shattering Efficiency

New mom Jasmin Paris gained the Montane Backbone Race alongside the Pennine Approach within the UK, smashing the earlier document by over 12 hours.

The 431-kilometer (268 mi) race is likely one of the most grueling endurance challenges in Europe. Runners go from Derbyshire to the Scottish border, spending round two-thirds of their trek at the hours of darkness.

They cowl a variety of hilly terrain and should climb over 13,000 meters (43,000 ft) in complete. They’ve to hold their very own package and provides and may’t have a help workforce or runner be a part of them on the course. Rivals carry an emergency button in case they’re not capable of stroll.

With a time of 83 hours, 12 minutes, and 23 seconds, Paris turned the primary lady to win the race and had the quickest time ever—by far. The earlier document of 95 hours and 17 minutes was set in 2016 by Eoin Keith.

Just some checkpoints are allowed in the course of the race, and Paris slept for less than three hours throughout the entire thing. She admitted that she had begun hallucinating by the final day. She noticed animals seem out of nowhere and timber doing morning stretches.[9]

1 Beer Saves Life

Beer might be good for you, and 48-year-old Vietnamese man Nguyen Van Nhat is proof of that. When he got here into the hospital unconscious, affected by methanol poisoning, docs pumped him with 15 cans of beer and saved his life.

Methanol is a type of alcohol. However it’s a very poisonous one which is usually present in paints, thinners, cleansing merchandise, and antifreeze slightly than drinks. Business spirit producers take additional steps to take away methanol from their merchandise, though it could possibly nonetheless be present in harmful portions in bootleg liquor.

The supply of the methanol consumed by Nguyen Van Nhat is unknown, however he had over 1,000 occasions the really helpful restrict. Docs knew that he would die if his liver processed all of the methanol in his system. The liver converts the alcohol into formaldehyde which is then damaged down into formic acid. Docs have been in search of a method to decelerate the method, they usually discovered it with beer.

Beer accommodates one other sort of alcohol referred to as ethanol. It’s the alcohol present in most shopper drinks on the planet. Though it’s nonetheless poisonous, its results are far milder. Because it occurs, the liver first processes ethanol and solely afterward strikes as much as methanol.

Subsequently, so long as there was beer in Nguyen Van Nhat’s system, his physique wouldn’t be broken by the methanol. Docs transfused 15 cans value of beer into the affected person at a fee of a can per hour, thus giving the dialysis sufficient time to take away the methanol from his system.[10]

The post 10 Uplifting Stories To Get You Through The Week (1/20/19) appeared first on List Technology.

[jimeshbathija3896-blog]

10 Uplifting Stories To Get You Through The Week (1/20/19)

To enable you to finish the week on a constructive observe, we’ve got gathered into one record all of the information which may raise your spirits. That is the place you’ll discover a good mixture of feel-good tales mixed with vital achievements and tales of true togetherness. For those who want one thing bizarre and wacky, take a look at the offbeat record.

This week, we study that the world’s loneliest frog has discovered a girlfriend. A pet has a miraculous survival, and a person’s life is saved by beer. There are a couple of probably “game-changing” medical breakthroughs, an excessive feat of endurance, and a humbling act of forgiveness.

10 Courtroom Clemency

The sufferer of a DUI hit surprised the courtroom when she not solely forgave her attacker but in addition requested for his assist.

Three and a half years in the past, Montreal lady Tina Adams went out for a jog and was hit by 22-year-old Jordan Taylor, who was drunk behind the wheel. Nineteen surgical procedures later, Tina was capable of overcome the fractured backbone, cracked cranium, mind damage, and blood clots she suffered within the crash.

She might have survived, however Adams will cope with ache for the remainder of her life. She will not turn out to be a police officer due to her accidents and should not be capable of have youngsters. Within the years because the crash, Tina has traveled to colleges to speak about her expertise and to warn college students of the risks of drunk driving.

She stunned everybody when she requested Taylor to hitch her on these faculty talks throughout his sentencing listening to.[1] Tina believes that having the man who hit her there could have a huge effect on the scholars. She had considered doing this for some time however needed to attend till assembly him in courtroom to see if he confirmed real regret.

9 Romeo Finds His Juliet

A lonely male frog as soon as considered the final of his variety lastly has a associate after a decade of solitude.

Romeo is a Sehuencas water frog. Ten years in the past, conservationists realized that the species was in hassle in order that they collected him from the wild to put him right into a breeding program. Nevertheless, they couldn’t discover a feminine appropriate for him. Romeo was left in isolation in a Bolivian aquarium.

Now he’s not alone. A current expedition into the wilderness of Bolivia turned up 5 new Sehuencas water frogs—three males and two females. Certainly one of them, named Juliet, shall be positioned with Romeo within the hopes that they’ll breed collectively. In the intervening time, all the brand new amphibians are nonetheless in quarantine.

Herpetologists are hoping that opposites will appeal to when the 2 lastly meet. Their personalities appear to be antithetical to one another. Whereas Romeo is calm, sluggish, and doesn’t transfer round quite a bit, Juliet could be very lively, swims always, and eats every part in sight.[2]

eight The Chief And The Good Samaritan

Final Saturday, the Kansas Metropolis Chiefs scored a playoff victory over the Indianapolis Colts and made their solution to the AFC Championship Recreation later in the present day. Nevertheless, issues may need turned out in another way have been it not for a Good Samaritan who stopped to lend a serving to hand.

Hours earlier than the sport was set to start out at Arrowhead Stadium in Kansas Metropolis, Missouri, Chiefs offensive lineman Jeff Allen was caught within the snow. He in all probability would have missed the match if Dave Cochran hadn’t pulled over in his truck and helped Allen transfer his car.

Because it later turned out, Cochran was homeless and dwelling in his truck. Nevertheless, that didn’t cease him from aiding different individuals, which he thought-about his “natural habit.” When he pulled over, he didn’t know he was coping with a Kansas Metropolis Chiefs participant. He noticed somebody with Texas plates on his automotive and figured that he in all probability wasn’t used to driving in snowy circumstances.

Allen was eager to return the favor and took to Twitter the subsequent day to succeed in out to Cochran. Inside a couple of hours, he was capable of contact his snowy savior and provides him a few tickets to the AFC Championship Recreation. Cochran admitted that he was solely anticipating a “thank you” however that Allen’s gesture is “like a dream come true.”[3]

7 A New Remedy

In accordance with a brand new research revealed within the journal Most cancers Cell, Swiss researchers from the College of Basel are engaged on a revolutionary new remedy which may change breast most cancers cells into innocent fats cells.

Most cancers cells can bear a course of referred to as epithelial-mesenchymal transition (EMT). Usually, that is one thing that makes them extremely harmful because it permits them to unfold to different kinds of cells within the physique. Nevertheless, scientists consider that the identical mechanism can be utilized towards them.[4]

Throughout an experiment, researchers injected feminine mice with an aggressive type of feminine breast most cancers. When the cells began present process EMT, the scientists additionally injected an antidiabetic drug referred to as rosiglitazone and a most cancers inhibitor named trametinib.

The mixed remedy not solely turned the most cancers cells into fats cells but in addition stopped them from proliferating. Furthermore, lead writer Gerhard Christofori believes that the remedy may have a shorter, simpler path to human trials as a result of the medicine concerned are already permitted.

6 50,000 Cures For Loneliness

Together with his birthday approaching, World Struggle II navy veteran Duane Sherman was feeling a bit lonely. His daughter requested associates on Fb if they might ship him some well-wishes. He acquired over 50,000 letters.

In the meanwhile, there are birthday playing cards, thanks notes, small presents, and mementos filling postal bins stacked one on prime of one other all all through Sherman’s residence in Fullerton, California. And that solely represents a fraction of the whole. He needed to retailer hundreds of letters at a pal’s home, and lots of extra bins are nonetheless ready to be picked up on the submit workplace.[5]

He has acquired letters from all 50 states and 10 totally different nations. A number of the senders included the Pittsburgh Steelers and the Secretary of the Navy. The commander of the united statesCowpens even took the vet out to lunch whereas officers from the San Diego US Navy Sonar Faculty paid him a go to to take heed to his tales.

Sherman’s birthday was on December 30, and up to now, he has gone by means of fewer than 2,000 letters. He’s legally blind, so his daughter, Sue Morse, has to learn them to him. It’s fairly protected to say that they are going to be busy for the foreseeable future.

5 How To Get Over A Case Of The Mondays

Tomorrow is Blue Monday, thought-about to be probably the most depressing day of the yr. However is there any fact to this, and are there methods of getting via the day with a smile in your face?

Proper off the bat, should you reside within the southern hemisphere, you’re off the hook. The chilly climate is among the essential elements which contribute to the distress.

The idea of “Blue Monday” got here from UK psychologist Cliff Arnall in 2005. It often falls on the third Monday of the yr. Arnall claims to have developed an equation to find out the saddest day utilizing elements comparable to climate, debt degree, time handed because the holidays, and time handed since individuals broke their New Yr’s resolutions.[6]

The entire factor was truly devised for an advert marketing campaign for trip firm Sky Journey. It has been often dismissed as pseudoscience. Even Arnall admitted that he by no means meant to make the day sound unfavourable however to encourage individuals to take motion.

Let’s say you feel down within the dumps. Even when Blue Monday is a fantasy, seasonal affective dysfunction (SAD) is actual. If you wish to raise your spirits, psychologists advocate a little bit of train, a pleasant stroll outdoors, and enjoyable, difficult indoor actions.

A more healthy weight loss plan wealthy in good fat and antioxidants can even assist to stop melancholy. There’s even mild remedy utilizing particular SAD lamps to make up for all that daylight you’re lacking throughout winter.

four Pet Drop Has Joyful Ending

A tiny pet miraculously survived a drop from the sky with no critical accidents after being kidnapped by a hawk.

Final Saturday, development staff in Austin, Texas, responded to cries belonging to a Chihuahua pooch which weighed lower than zero.5 kilograms (1 lb). Questioning how the canine obtained there within the first place, they seemed up and noticed a hawk circling above. They realized that the raptor had picked up the pet and dropped it from the air.

The staff took the canine to the Austin Animal Middle the place vets have been stunned to find that the animal had solely delicate accidents and no damaged bones. The worst of the bunch have been the puncture wounds brought on by the hawk’s talons, however even these will heal up utterly in due time. The pet, now referred to as Tony Hawk, is resting together with his foster household and can discover a everlasting house in a couple of weeks.[7]

three A Recreation-Altering Transplant

Medical specialists are hailing a brand new process for liver transplants as a “game-changer” which can halve the ready listing.

Proper now, a few third of all donated livers by no means make it right into a affected person. On the similar time, 20 % of individuals in want of a brand new liver die on the ready record. That is because of the regular storage technique which makes use of ice. It causes the organ to deteriorate, and there’s solely a restricted time to transplant it earlier than it turns into unusable.

A brand new remedy makes use of normothermic perfusion machines to protect the liver. They continually pump the organ with oxygenated blood and vitamins at physique temperature in order that it may be saved for longer durations of time with no sick results.[8]

Furthermore, the blood remedy can truly be used to restore livers which have been broken throughout removing or have come from aged or sick donors. Subsequently, they permit docs to make use of organs which in any other case would have been discarded.

2 A Shattering Efficiency

New mom Jasmin Paris gained the Montane Backbone Race alongside the Pennine Approach within the UK, smashing the earlier document by over 12 hours.

The 431-kilometer (268 mi) race is likely one of the most grueling endurance challenges in Europe. Runners go from Derbyshire to the Scottish border, spending round two-thirds of their trek at the hours of darkness.

They cowl a variety of hilly terrain and should climb over 13,000 meters (43,000 ft) in complete. They’ve to hold their very own package and provides and may’t have a help workforce or runner be a part of them on the course. Rivals carry an emergency button in case they’re not capable of stroll.

With a time of 83 hours, 12 minutes, and 23 seconds, Paris turned the primary lady to win the race and had the quickest time ever—by far. The earlier document of 95 hours and 17 minutes was set in 2016 by Eoin Keith.

Just some checkpoints are allowed in the course of the race, and Paris slept for less than three hours throughout the entire thing. She admitted that she had begun hallucinating by the final day. She noticed animals seem out of nowhere and timber doing morning stretches.[9]

1 Beer Saves Life

Beer might be good for you, and 48-year-old Vietnamese man Nguyen Van Nhat is proof of that. When he got here into the hospital unconscious, affected by methanol poisoning, docs pumped him with 15 cans of beer and saved his life.

Methanol is a type of alcohol. However it’s a very poisonous one which is usually present in paints, thinners, cleansing merchandise, and antifreeze slightly than drinks. Business spirit producers take additional steps to take away methanol from their merchandise, though it could possibly nonetheless be present in harmful portions in bootleg liquor.

The supply of the methanol consumed by Nguyen Van Nhat is unknown, however he had over 1,000 occasions the really helpful restrict. Docs knew that he would die if his liver processed all of the methanol in his system. The liver converts the alcohol into formaldehyde which is then damaged down into formic acid. Docs have been in search of a method to decelerate the method, they usually discovered it with beer.

Beer accommodates one other sort of alcohol referred to as ethanol. It’s the alcohol present in most shopper drinks on the planet. Though it’s nonetheless poisonous, its results are far milder. Because it occurs, the liver first processes ethanol and solely afterward strikes as much as methanol.

Subsequently, so long as there was beer in Nguyen Van Nhat’s system, his physique wouldn’t be broken by the methanol. Docs transfused 15 cans value of beer into the affected person at a fee of a can per hour, thus giving the dialysis sufficient time to take away the methanol from his system.[10]

The post 10 Uplifting Stories To Get You Through The Week (1/20/19) appeared first on List Technology.

[superplhis-blog]

10 Uplifting Stories To Get You Through The Week (1/20/19)

To enable you to finish the week on a constructive observe, we’ve got gathered into one record all of the information which may raise your spirits. That is the place you’ll discover a good mixture of feel-good tales mixed with vital achievements and tales of true togetherness. For those who want one thing bizarre and wacky, take a look at the offbeat record.

This week, we study that the world’s loneliest frog has discovered a girlfriend. A pet has a miraculous survival, and a person’s life is saved by beer. There are a couple of probably “game-changing” medical breakthroughs, an excessive feat of endurance, and a humbling act of forgiveness.

10 Courtroom Clemency

The sufferer of a DUI hit surprised the courtroom when she not solely forgave her attacker but in addition requested for his assist.

Three and a half years in the past, Montreal lady Tina Adams went out for a jog and was hit by 22-year-old Jordan Taylor, who was drunk behind the wheel. Nineteen surgical procedures later, Tina was capable of overcome the fractured backbone, cracked cranium, mind damage, and blood clots she suffered within the crash.

She might have survived, however Adams will cope with ache for the remainder of her life. She will not turn out to be a police officer due to her accidents and should not be capable of have youngsters. Within the years because the crash, Tina has traveled to colleges to speak about her expertise and to warn college students of the risks of drunk driving.

She stunned everybody when she requested Taylor to hitch her on these faculty talks throughout his sentencing listening to.[1] Tina believes that having the man who hit her there could have a huge effect on the scholars. She had considered doing this for some time however needed to attend till assembly him in courtroom to see if he confirmed real regret.

9 Romeo Finds His Juliet

A lonely male frog as soon as considered the final of his variety lastly has a associate after a decade of solitude.

Romeo is a Sehuencas water frog. Ten years in the past, conservationists realized that the species was in hassle in order that they collected him from the wild to put him right into a breeding program. Nevertheless, they couldn’t discover a feminine appropriate for him. Romeo was left in isolation in a Bolivian aquarium.

Now he’s not alone. A current expedition into the wilderness of Bolivia turned up 5 new Sehuencas water frogs—three males and two females. Certainly one of them, named Juliet, shall be positioned with Romeo within the hopes that they’ll breed collectively. In the intervening time, all the brand new amphibians are nonetheless in quarantine.

Herpetologists are hoping that opposites will appeal to when the 2 lastly meet. Their personalities appear to be antithetical to one another. Whereas Romeo is calm, sluggish, and doesn’t transfer round quite a bit, Juliet could be very lively, swims always, and eats every part in sight.[2]

eight The Chief And The Good Samaritan

Final Saturday, the Kansas Metropolis Chiefs scored a playoff victory over the Indianapolis Colts and made their solution to the AFC Championship Recreation later in the present day. Nevertheless, issues may need turned out in another way have been it not for a Good Samaritan who stopped to lend a serving to hand.

Hours earlier than the sport was set to start out at Arrowhead Stadium in Kansas Metropolis, Missouri, Chiefs offensive lineman Jeff Allen was caught within the snow. He in all probability would have missed the match if Dave Cochran hadn’t pulled over in his truck and helped Allen transfer his car.

Because it later turned out, Cochran was homeless and dwelling in his truck. Nevertheless, that didn’t cease him from aiding different individuals, which he thought-about his “natural habit.” When he pulled over, he didn’t know he was coping with a Kansas Metropolis Chiefs participant. He noticed somebody with Texas plates on his automotive and figured that he in all probability wasn’t used to driving in snowy circumstances.

Allen was eager to return the favor and took to Twitter the subsequent day to succeed in out to Cochran. Inside a couple of hours, he was capable of contact his snowy savior and provides him a few tickets to the AFC Championship Recreation. Cochran admitted that he was solely anticipating a “thank you” however that Allen’s gesture is “like a dream come true.”[3]

7 A New Remedy

In accordance with a brand new research revealed within the journal Most cancers Cell, Swiss researchers from the College of Basel are engaged on a revolutionary new remedy which may change breast most cancers cells into innocent fats cells.

Most cancers cells can bear a course of referred to as epithelial-mesenchymal transition (EMT). Usually, that is one thing that makes them extremely harmful because it permits them to unfold to different kinds of cells within the physique. Nevertheless, scientists consider that the identical mechanism can be utilized towards them.[4]

Throughout an experiment, researchers injected feminine mice with an aggressive type of feminine breast most cancers. When the cells began present process EMT, the scientists additionally injected an antidiabetic drug referred to as rosiglitazone and a most cancers inhibitor named trametinib.

The mixed remedy not solely turned the most cancers cells into fats cells but in addition stopped them from proliferating. Furthermore, lead writer Gerhard Christofori believes that the remedy may have a shorter, simpler path to human trials as a result of the medicine concerned are already permitted.

6 50,000 Cures For Loneliness

Together with his birthday approaching, World Struggle II navy veteran Duane Sherman was feeling a bit lonely. His daughter requested associates on Fb if they might ship him some well-wishes. He acquired over 50,000 letters.

In the meanwhile, there are birthday playing cards, thanks notes, small presents, and mementos filling postal bins stacked one on prime of one other all all through Sherman’s residence in Fullerton, California. And that solely represents a fraction of the whole. He needed to retailer hundreds of letters at a pal’s home, and lots of extra bins are nonetheless ready to be picked up on the submit workplace.[5]

He has acquired letters from all 50 states and 10 totally different nations. A number of the senders included the Pittsburgh Steelers and the Secretary of the Navy. The commander of the united statesCowpens even took the vet out to lunch whereas officers from the San Diego US Navy Sonar Faculty paid him a go to to take heed to his tales.

Sherman’s birthday was on December 30, and up to now, he has gone by means of fewer than 2,000 letters. He’s legally blind, so his daughter, Sue Morse, has to learn them to him. It’s fairly protected to say that they are going to be busy for the foreseeable future.

5 How To Get Over A Case Of The Mondays

Tomorrow is Blue Monday, thought-about to be probably the most depressing day of the yr. However is there any fact to this, and are there methods of getting via the day with a smile in your face?

Proper off the bat, should you reside within the southern hemisphere, you’re off the hook. The chilly climate is among the essential elements which contribute to the distress.

The idea of “Blue Monday” got here from UK psychologist Cliff Arnall in 2005. It often falls on the third Monday of the yr. Arnall claims to have developed an equation to find out the saddest day utilizing elements comparable to climate, debt degree, time handed because the holidays, and time handed since individuals broke their New Yr’s resolutions.[6]

The entire factor was truly devised for an advert marketing campaign for trip firm Sky Journey. It has been often dismissed as pseudoscience. Even Arnall admitted that he by no means meant to make the day sound unfavourable however to encourage individuals to take motion.

Let’s say you feel down within the dumps. Even when Blue Monday is a fantasy, seasonal affective dysfunction (SAD) is actual. If you wish to raise your spirits, psychologists advocate a little bit of train, a pleasant stroll outdoors, and enjoyable, difficult indoor actions.

A more healthy weight loss plan wealthy in good fat and antioxidants can even assist to stop melancholy. There’s even mild remedy utilizing particular SAD lamps to make up for all that daylight you’re lacking throughout winter.

four Pet Drop Has Joyful Ending

A tiny pet miraculously survived a drop from the sky with no critical accidents after being kidnapped by a hawk.

Final Saturday, development staff in Austin, Texas, responded to cries belonging to a Chihuahua pooch which weighed lower than zero.5 kilograms (1 lb). Questioning how the canine obtained there within the first place, they seemed up and noticed a hawk circling above. They realized that the raptor had picked up the pet and dropped it from the air.

The staff took the canine to the Austin Animal Middle the place vets have been stunned to find that the animal had solely delicate accidents and no damaged bones. The worst of the bunch have been the puncture wounds brought on by the hawk’s talons, however even these will heal up utterly in due time. The pet, now referred to as Tony Hawk, is resting together with his foster household and can discover a everlasting house in a couple of weeks.[7]

three A Recreation-Altering Transplant

Medical specialists are hailing a brand new process for liver transplants as a “game-changer” which can halve the ready listing.

Proper now, a few third of all donated livers by no means make it right into a affected person. On the similar time, 20 % of individuals in want of a brand new liver die on the ready record. That is because of the regular storage technique which makes use of ice. It causes the organ to deteriorate, and there’s solely a restricted time to transplant it earlier than it turns into unusable.

A brand new remedy makes use of normothermic perfusion machines to protect the liver. They continually pump the organ with oxygenated blood and vitamins at physique temperature in order that it may be saved for longer durations of time with no sick results.[8]

Furthermore, the blood remedy can truly be used to restore livers which have been broken throughout removing or have come from aged or sick donors. Subsequently, they permit docs to make use of organs which in any other case would have been discarded.

2 A Shattering Efficiency

New mom Jasmin Paris gained the Montane Backbone Race alongside the Pennine Approach within the UK, smashing the earlier document by over 12 hours.

The 431-kilometer (268 mi) race is likely one of the most grueling endurance challenges in Europe. Runners go from Derbyshire to the Scottish border, spending round two-thirds of their trek at the hours of darkness.

They cowl a variety of hilly terrain and should climb over 13,000 meters (43,000 ft) in complete. They’ve to hold their very own package and provides and may’t have a help workforce or runner be a part of them on the course. Rivals carry an emergency button in case they’re not capable of stroll.

With a time of 83 hours, 12 minutes, and 23 seconds, Paris turned the primary lady to win the race and had the quickest time ever—by far. The earlier document of 95 hours and 17 minutes was set in 2016 by Eoin Keith.

Just some checkpoints are allowed in the course of the race, and Paris slept for less than three hours throughout the entire thing. She admitted that she had begun hallucinating by the final day. She noticed animals seem out of nowhere and timber doing morning stretches.[9]

1 Beer Saves Life

Beer might be good for you, and 48-year-old Vietnamese man Nguyen Van Nhat is proof of that. When he got here into the hospital unconscious, affected by methanol poisoning, docs pumped him with 15 cans of beer and saved his life.

Methanol is a type of alcohol. However it’s a very poisonous one which is usually present in paints, thinners, cleansing merchandise, and antifreeze slightly than drinks. Business spirit producers take additional steps to take away methanol from their merchandise, though it could possibly nonetheless be present in harmful portions in bootleg liquor.

The supply of the methanol consumed by Nguyen Van Nhat is unknown, however he had over 1,000 occasions the really helpful restrict. Docs knew that he would die if his liver processed all of the methanol in his system. The liver converts the alcohol into formaldehyde which is then damaged down into formic acid. Docs have been in search of a method to decelerate the method, they usually discovered it with beer.

Beer accommodates one other sort of alcohol referred to as ethanol. It’s the alcohol present in most shopper drinks on the planet. Though it’s nonetheless poisonous, its results are far milder. Because it occurs, the liver first processes ethanol and solely afterward strikes as much as methanol.

Subsequently, so long as there was beer in Nguyen Van Nhat’s system, his physique wouldn’t be broken by the methanol. Docs transfused 15 cans value of beer into the affected person at a fee of a can per hour, thus giving the dialysis sufficient time to take away the methanol from his system.[10]

The post 10 Uplifting Stories To Get You Through The Week (1/20/19) appeared first on List Technology.

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Vinicio A de Jesus Perez, MD - phaware® interview 157

Vinicio de Jesus Perez, MD is Assistant Professor of Medicine (Pulmonary and Critical Care Medicine) at the Stanford Adult PH Clinic where he trains fellows pursuing careers in PH and IPF. He is principal investigator of a research program with the ultimate goal of identifying new therapeutic targets to treat PH and IPF. In this episode, Dr. Vinicio de Jesus Perez discusses pulmonary arterial hypertension as a complication of methamphetamine use (METH-PAH).

My name is Vincinio de Jesus Perez. I am an assistant professor in the Division of Pulmonary Critical Care Medicine at Stanford University. I’m also a staff physician in the Adult Pulmonary Hypertension Clinic, also at Stanford. 

Today, I would like to talk to you about how environmental and genetic factors interact to increase the risk of pulmonary hypertension in a subset of our population. I think the story with methamphetamines starts back in 2006, at least for me. Around that time I had joined the lab of Dr. Marlene Rabinovitch. I was spending some time in the pulmonary hypertension clinic. I wanted to learn how to assess, follow, treat patients with pulmonary hypertension. I remember seeing quite a few cases of patients who will come to us for pulmonary hypertension and, again, being at a time when I was trying to cover all bases, a lot of times I’m asking about drug history.

The first thing obviously when you think about PH and drug history is anorexigens, so I’m asking if they were taking weight loss agents or cocaine and a lot of the patients will venture that they had tried methamphetamines. Back then the seizure of methamphetamines, the number of meth kitchen explosions, all of that was really high, and we were just really at the epicenter of all of that. Roham Zamanian, MD and I started talking and said, “You know, there is an opportunity here.” We were starting a database. We were starting to collect blood, so Roham had taken leadership over the tissue bank. We had started the pulmonary hypertension breakthrough initiative and I had become interested in understanding genetics so I enrolled in an NIH K12 program looking at genetics of pulmonary hypertension.

I think it was fortuitous because we were at the right place at the right time. Roham started capturing very comprehensive clinical profiles of every patient with methamphetamine related pulmonary hypertension that came to the clinic. I started to take advantage of the blood samples we had on our bio-bank and I decided to conduct a study using whole exome sequencing, which is one of the next generation sequencing strategies where we can actually screen every gene in the genome. We look at the coding regions, those parts of the genes that actually become part of the protein.

Looking at mutations, disease causing variants, we started finding some really interesting candidate genes that were not necessarily your traditional PH related genes, like BMPR-2 or ALK-1, for example. While we were doing some epidemiology and clinical assessment, we started looking at a very interesting genetic candidate that we found in our whole exome stream called carboxylesterase CES1. Now, the interesting thing about that gene and the reason why we thought it will be a good way to validate the genetic data we observe in our population was that this is actually one of the genes that together with the cytochromes are involved with the detoxification of compounds, whether they’re medications, whether they are toxins, illicit substances.

This particular enzyme is important in detoxifying cocaine, heroin, methylphenidate, and some amphetamine-based compounds. With that we started looking at blood and cells and lung tissue from patients with methamphetamine PH that we had obtained at the time of transplant and, lo and behold, we started seeing the same genetic variants and ultimately ended up validating this as a susceptibility gene that when the endothelial cells, for example, are exposed to methamphetamine, if they lack this gene or if they have one of the mutations we found in our population, the endothelial cells are more likely to die out.

Now what does that mean when it comes to PH? Well, one of the things that we see commonly in patients with pulmonary hypertension and methamphetamine PH being no exception is that there is a progressive disappearance of blood vessels. Part of what we think causes that is that the endothelial cells are being damaged and they die out and ultimately there is a transition to cell growth that ultimately narrows and occludes that blood vessel. If you think about it, not everybody that takes methamphetamine develops pulmonary hypertension. If so, we will be overrun with these cases so there has to be something in this population, a genetic susceptibility or factors that increase the risk of that patient for developing the disease.

What we are proposing is that if you carry a genetic susceptibility, in this case CES1 being an example, but we found a few others that we are actively assessing. Then, you may actually have a greater risk of injuring your pulmonary circulation incapacitating the ability of cells to regenerate in the setting of injury. One of the key questions is, what happens to methamphetamine when you take it? Whether you inhale, inject, put it in your mouth? What happens when the methamphetamine hits the lung? Is it causing inflammation? How does it cause damage, it’s not been clear.

Well, what we ended up discovering is that if you give methamphetamine to endothelial cells in culture these cells can actually uptake methamphetamine. In other words, methamphetamine can make its way inside the cell and the endothelial cell has the capacity to start detoxifying methamphetamine. The endothelial cell has evolved into a system that it can actually interact and detoxify some of these compounds, methamphetamine being one but I will imagine cocaine and other compounds.

If there is anything that compromises the capacity of the endothelial cell to carry out this activity, then I think that may increase the risk of endothelial loss, vascular damage, impaired regeneration, which ultimately will result in pulmonary hypertension. Now, how does this translate into patients? Well, pulmonary hypertension is well characterized. When it comes to looking at the patients, with catheterization, they have high pressures, they meet the criteria that we currently accept for defining pulmonary arterial hypertension, the WHO Group 1.

OK fine, but what is the pathology? Does the pathology of vascular remodeling in methamphetamine PAH look the same as that we see with idiopathic, familial, and the other forms that are not being explored. Roham and I went back to our tissue bank and patients that had undergone lung transplant, we had captured some of those lungs and we decided to stain the lungs and work with our pathologist.

What we found was that, indeed, the lesions that we saw in the lungs were completely indistinguishable from what you will see in a patient with any form of PH, whether it is idiopathic, drug induced. We’re talking about a phenotype that belongs within WHO Group 1. You can make the argument that the medications that we’re currently using should also work and maybe some of the same clinical molecular pathways are shared.

The question is, is there something unique here that affects how these patients react and how these patients evolve. In our paper which we published in 2017, we actually found something really interesting. It’s that if you follow the survival of these patients, meth PAH, and you compare them with patients who are idiopathic they have a much worse survival. This is after we controlled for age, sex, social status, et cetera.

What that made us think is that if you are a methamphetamine PH patient you probably have a phenotype that is different from an idiopathic patient and you may be at a higher risk of more aggressive, a less salutary response to therapy, we don’t know. It definitely made us imagine that similar to what’s been shown with connective tissue disease; PH, HIV, PAH, these patients may just have a more aggressive phenotype that we may need to be aware of so that we can be understandably more aggressive to treat these patients.

The last thing that we found, which is of relevance to how these patients are treated, is that compared to the idiopathic PH patients there are less of these patients that are actually on IV and sub-Q therapy. The problem there, unfortunately, is that many of these patients, due to active and continued methamphetamine use, as well as poor social support and other limitations, unfortunately cannot be candidates for these therapies.

One of my most memorable, and I have to say sad, cases of methamphetamine PH was a couple of years ago. A patient of ours who arrived with a history of active methamphetamine use came with very severe PAH requiring intervention including social worker, including aggressive diagnosis. Ultimately, he was able to stop using methamphetamine. He was so severe, he was a functional Class IV, we decided to start him on IV remodulin with a Hickman catheter and he did remarkably well. His echo improved, his six minute walk, functional class, REVEAL score, it was exactly what you will like to see when you start a patient with these drugs.

However, a couple of months down the road I get called because the patient is in the emergency room and he was in cardiac arrest. When we went in, the first thing we thought of is that he had a blockage in his remodulin infusion. What we ended up doing was we unplugged the catheter, we tried to flush, and indeed there was an obstruction. We start pulling trying to see because the first thing we thought of is that maybe there’s a clot there. Instead, what we found is this white, pasty substance that was filling the inside of the catheter, which it should come as no surprise was actually methamphetamine.

The patient sadly passed away a couple of days later, but I think that tells you a couple of things. Number one, methamphetamine is a really addictive substance, it’s really hard to get rid of. Even though we had followed the patient with sporadic urine tests, for whatever reason the patient had gone back. Number two, it also made us extremely aware that these patients have to be screened and that we have to be careful. Even though a patient like this you will say, “Well, he’s a functional Class IV, patient is super sick, the medication needs to be started,” he may not necessarily benefit and even could be at high risk of potential complications not necessarily associated with the drug, associated with methamphetamine addiction. 

Every time that I see a meth patient in my clinic I tell them that story. That’s my come to Jesus moment, sort of like, “Listen, just stop fooling around. You need to put life in perspective. If you keep using methamphetamine you’re going to die.” We have a policy that we don’t start patients on PH medications until we are clear that the patient is not using methamphetamine. As a matter of fact, the day they come for their catheterization, we do a urine spot because if they are on methamphetamine, which has happened, we cannot do the study.

Methamphetamine is sympathicomimetic medication so pressures are going to be worse. As a matter of fact, just stopping methamphetamine results in a remarkable improvement in pulmonary resistance and pressures. Again, you can tell this to a patient, but addiction is definitely a very poor prognostic indicator for this patient population.

My name is Vincinio de Jesus Perez and I am aware that I’m rare.

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