#cadasil

[foxynovacoda]

A li'l meme I made (probably historically inaccurate)

[canary-prince]

I feel like I could make a neat fic series out of the Usher kids' name meanings

Like a series of character studies through the lens of their names' etymologies.

FREDERICK: Peaceful ruler. Control freaks shouldn't be spineless, it's awfully frustrating for them. He wants to be in charge but is a conflict avoidant suck-up, insecure and petty. A peace-time king, no glory to his name, inheriting from a warrior and a sorceress who fought and bit and clawed. Under real challenge, he crumbles. A peace-time king becomes known from one of two things: that which they build and that which they heal. A peace-time king who is sung about? Bridge-builders, feeders of the poor; castle-builders, patrons of the arts; church-builders, tenders of the sick. But Frederick does not focus on the kingdom that has already been built, on the legacy to be preserved. Instead he longs for new lands to conquer, and new legacies to write. Outside his castle gates, the poor starve and the sick die and the artists are forced to take new jobs. I weep for bridges never built.

TAMERLANE: Iron. Cold and sharp and inflexible. A sword, a gun, a railroad track, an imposing bridge, an unassailable gate. She thinks she's invincible, but impurities and brittleness remain: she is not yet steel and ultimately never became steel. In the end, the fire does not cleanse or forge her: she simply melts away. We inherited iron from the dying stars of eons ago: it is in our blood, it gives us energy and strength and without we waste away to nothing. This is actually a boy's name, which is FASCINATING. How many women in history were buried beneath the legacies of their fathers and brothers and sons? So she hardened and sharpened and tried to prove herself.

VICTORINE: Victory. Locked in competition with her siblings, particularly Camille. She does whatever it takes to "win": arguments, pissing contests, "at life", against death. When Roderick reveals his CADASIL diagnosis, Victorine is the weapon he and Madeline attempt to wield against the disease, as if she can "beat" the deal they struck. She constantly tries to position herself as allied with Tammy and Frederick, on the "winning" team, on the side of the "legitimate" children. She lies, she cheats, and refuses to give her medals back when she's caught. Her nickname, 'Vic', is also cop show slang for 'victim'. She thinks these things happen TO her, not BECAUSE of her...but all of the kids are Roderick and Madeline's victims. He ruined her. Like he ruined all of them. Pyrrhic Victory indeed.

CAMILLE: This name can mean "perfect" or it can mean "acolyte", and either one can work, but I lean more towards the second meaning. A young initiate into a cult (here meaning the organized followers of a particular god, not the Lifton style destructive cult) there to spread the myth and carry on the traditions. She is the keeper of secrets and the teller of stories, isolated from the outside world, steeped in ritual for ritual's sake. Priests and priestesses may have employed psychedelic drugs and illusionist tricks to awe and entertain their followers or indue holy visions. Female cult initiates were often unmarried priestesses: either through widowhood or refusing to marry when young. Mystery cults were hidden or secret traditions, often focused on mystical re-interpretation of the mainstream tradition.

NAPOLEON: So the best translation for this name that we have is "Lion of Naples" or "Lion of the New City". Focusing on the "Lion" part, lions are social and lazy, most active at night. Males orbit the periphery while females form the heart of the unit. Male lions hunt alone, often as ambush predators, but general misconception is that they do not hunt at all, due to "failing" at it, compared to females. Furthermore, male lions will form "coalitions" with other males as opposed to priding up with females and cubs (Asiatic lions in particular are prone to this) and lions are one of the primary species in which we have observed bisexuality among males. Finally, lions make great dads and Leo is one of the only siblings who shows genuine grief over the family's losses.

PROSPERO: Prosperity or Fortunate. His name is symbolic of the changing tides of fortune, and is a reference to Fortunado itself. He was only 16 when he became a legitimized heir. That's a hard age to adjust to all that. He is gluttonous and lustful, soaking up every little bit of the privilege his family money gives him. What is the point of gull eggs, exactly? He is blessed with beauty: so much of it that even Verna comments on it. He assumes his blessings will never run out, and plays with fire by attempting to commit mass blackmail and ignoring all the red flags about the party venue, yet, at the same time? He thinks the world still owes him something more. Everything must be handed to him. It is his birth right, all of it. Earning it is for the unlucky: he is blessed.

[absolutelyfibulas]

Had a lil cry, then fell asleep on sofa for three hours by accident lol. I wasn't particularly close to my aunt, but she was the only aunty I had who was really recurring in my life from childhood (my dad's side are all very sporadic in interaction etc), so it's a bit...yeah :(

Details under cut

I got a text on Tuesday from mum to say my aunty'd had a fall. Then she phoned me about an hour later to tell me that, after said fall, my cousin had noticed a few signs of stroke and called mum for advice (mum being a former nurse). Mum talked to Aunty, and was like "yeah she's had a stroke, get her to hospital etc".

Paramedics got her to hospital where she quickly got worse, to the extent my mum travelled to Yorkshire to be with her. Apparently Aunt had 4 strokes, and they were basically told they'd just have to wait the next 2 days to know whether she was going to get better or worse.

She was stable Tues night, and woke up Weds, but was very muddled and unable to swallow or talk (though she was trying to). She was also forgetting who people were, then knowing who they were intermittently. One step forward, one step back, according to my mum. She wasn't getting worse, but she also wasn't improving, and they were sort of stuck seeing if she'd at least stabilise in the next 24 hours.

Mum texted me today to tell me she worsened overnight, and has now been put on the Liverpool pathway (pain meds to make her comfy but no more direct medical intervention), so now it's just waiting. Which sucks.

I'm mostly worried about my mum at this point, because she's going to be alone. Sort of. She's got us, obviously, but her parents both died when she was a young adult, and her older brother died really suddenly in his early 40s. The only other person from her childhood left is her sister, and her cousin - who lives in the US and has her own health problems making it unlikely she'll ever travel out the country again.

I know she'll dwell on this somewhat, and the fact it came out of nowhere (again, given how sudden her brother's death was) is...rough. My aunt had her own mental health issues, and atrial fibrillation which significantly increases the risk of stroke, but she was otherwise quite healthy, alert, and mostly independent. Then bam.

Brings up all the old existential stuff and anxiety, I guess. Mum does at least have us, and dad lost his brother last year so they can support one another through that (though I was less concerned on the loneliness front with dad because he still has 4 other siblings left). My cousin's (Cousin 1) kids are all scattered/unreliable, and her brother (Cousin 2) is a shithead. So they're probably going to have a rougher time, which I have no strong feelings about tbh. Cousin 1 I don't particularly like, but respect that she actually stuck by her mum for years and did her best to support and care for her. Cousin 2 fucked off after his parents divorced to leech money off his daddy, then only went crawling back after my Aunt got a big payment from the divorce.

Which brings me to the one silly petty thing about all this: I'm a little bit salty that she's not going to outlive her shitty abusive ex-husband. Like, okay, yes, his life was ruined by their divorce and everything (which, without derailing into a whole other topic, he completely fucking deserved lol), but I kind of wanted her to be able to see him out.

I dunno man, it's just been a rough week. This comes after me having to chase medical test results that came back clear - only now I have a potential new symptom which points right back to my initial concern...which my GP dismissed out of hand due to my blood test results. (I may have a goitre. Fun, right?)

Then mum decided to message me and my sister family health history the day before this happened. Which, y'know. Dad's side has the CADASIL gene, and my mum's side has a lot of Sudden Deaths, though doesn't seem to be related to anything genetic (they're all different causes). Just brings home the passage of time, and aging and dying and all that shite.

[taniyaaskd]

"Focusing on CADASIL Care: Advances in Treatment Solutions"

"Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market Size And Forecast by 2032

The global Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market study offers a thorough examination of the industry, highlighting the influence of leading companies on market dynamics and growth. These key players set the benchmark for innovation and operational excellence, contributing significantly to the development of the market. The study delves into their strategic initiatives, offering insights into how they navigate challenges and capitalize on opportunities. By focusing on these companies, the report paints a vivid picture of the competitive environment and its evolution.

Data Bridge Market Research analyses that the Global Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market which was USD 2772.5 Million in 2022 is expected to reach USD 3991.02 Million by 2030 and is expected to undergo a CAGR of 4.50% during the forecast period of 2022 to 2030

the outlook for the Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market remains optimistic, with significant opportunities for growth and innovation. The market’s competitive environment, shaped by leading companies and their strategies, underscores the importance of adaptability and foresight. With a focus on insights, trends, and data-driven analysis, this report serves as a comprehensive guide for stakeholders navigating the complexities of the Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market.

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Which are the top companies operating in the Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market?

The Top 10 Companies in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market are known for their strong presence and innovative solutions. These include industry leaders.  Each of these companies has made significant contributions through cutting-edge products, strategic partnerships, and global reach. Their ability to adapt to market trends and consumer demands has helped them maintain leadership positions in the market, driving growth and setting industry standards.

**Segments**

- By Treatment Type: - Medications - Surgery - Symptomatic Treatment

- By End-User: - Hospitals - Clinics - Research Institutes

- By Region: - North America - Europe - Asia Pacific - Latin America - Middle East & Africa

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) treatment market is segmented based on treatment type, end-user, and region. In terms of treatment type, the market is categorized into medications, surgery, and symptomatic treatment. Medications play a crucial role in managing CADASIL symptoms and preventing complications. Surgical interventions may be necessary in more severe cases to address specific issues such as stroke risk. Symptomatic treatment focuses on alleviating specific symptoms to improve the patient's quality of life. The end-users of CADASIL treatment include hospitals, clinics, and research institutes. Hospitals are key contributors to the market due to the availability of advanced treatment options and skilled healthcare professionals. Clinics provide ongoing care and monitoring for CADASIL patients, while research institutes drive innovation and advancements in treatment approaches. Geographically, the market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa, with North America and Europe leading in market share due to well-established healthcare infrastructure and high prevalence of CADASIL cases.

**Market Players**

- Novartis AG - Pfizer Inc. - Sanofi - AbbVie Inc. - Merck & Co., Inc. - Teva Pharmaceutical Industries Ltd. - Biogen - AstraZeneca - Bayer AG - Johnson & Johnson

Key market players in the CADASIL treatment market include Novartis AG, Pfizer Inc., Sanofi, AbbVie Inc., Merck & Co., Inc., Teva Pharmaceutical IndustriesThe CADASIL treatment market is highly competitive, with key players vying for market share through innovative treatment options and strategic partnerships. Novartis AG is a prominent player in the market, offering a range of medications and therapies for CADASIL patients. Pfizer Inc. is another major player known for its research and development efforts in neurological disorders. Sanofi and AbbVie Inc. also have a significant presence in the market, focusing on developing targeted therapies for CADASIL. Merck & Co., Inc. and Teva Pharmaceutical Industries Ltd. bring a wealth of experience in developing treatments for complex diseases, including CADASIL. Biogen is a key player in the market, with a strong focus on neurological disorders and innovative treatment approaches. AstraZeneca, Bayer AG, and Johnson & Johnson are also actively involved in the CADASIL treatment market, leveraging their expertise and resources to drive advancements in treatment options for patients.

These market players are investing heavily in research and development to bring novel therapies to the market, aiming to address the unmet needs of CADASIL patients. Collaborations with academic institutions, research organizations, and healthcare providers are key strategies adopted by these players to accelerate the development and commercialization of new treatments. Additionally, initiatives to raise awareness about CADASIL among healthcare professionals and patients are crucial for increasing the diagnosis rates and ensuring timely intervention.

The CADASIL treatment market is witnessing significant growth due to the rising prevalence of CADASIL globally and the increasing focus on personalized medicine and precision healthcare. Advances in genomics and neuroscience have led to a better understanding of the underlying mechanisms of CADASIL, paving the way for targeted therapies and personalized treatment approaches. The market players are leveraging this knowledge to develop innovative medications, surgical techniques, and symptomatic treatments that can improve the quality of life for CADASIL patients.

Factors such as increasing healthcare expenditure, growing geriatric population, and rising awareness about neurological disorders are driving the growth of the CADASIL treatment market.**Market Players**

- Novartis AG - Pfizer Inc. - Sanofi - AbbVie Inc. - Merck & Co., Inc. - Teva Pharmaceutical Industries Ltd. - Biogen - AstraZeneca - Bayer AG - Johnson & Johnson - Abbvie Inc. (U.S.) - Fresenius Kabi AG (Germany) - Hikma Pharmaceuticals PLC (U.K.) - Athenex, Inc (U.S.) - Eisai Co., Ltd (Japan) - Jubilant Life Sciences Ltd. (India) - Dr. Reddy’s Laboratories Ltd (India) - Zydus Cadila (India) - Aurobindo Pharma (India) - Teva Pharmaceutical Industries Ltd. (Israel) - Novartis AG (Germany) - WOCKHARDT (India) - Mylan N.V. (U.S.) - Sun Pharmaceutical Industries Ltd. (India) - Cipla Inc. (India) - Unichem Laboratories (India) - Stemedica Cell Technologies (U.S.) - Pfizer Inc. (U.S.) - Merck & Co., Inc. (U.S.) - Bayer AG (Germany) - Takeda Pharmaceutical Company Limited (Japan)

The CADASIL treatment market is experiencing robust growth due to factors such as the increasing prevalence of CADASIL globally, the emphasis on personalized medicine, and advancements in genomics and neuroscience. The market players mentioned above are at the

Explore Further Details about This Research Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market Report https://www.databridgemarketresearch.com/reports/global-cardasil-treatment-market

Key Insights from the Global Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market :

Comprehensive Market Overview: The Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Treatment Market is growing rapidly, driven by technological advancements and evolving consumer preferences.

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[crybaby611]

today

05/31/2024

possible CADASIL

answers but not what i wanted i guess

what exactly did i want or expect

[leedsomics]

Plasma Proteomics of Genetic Brain Arteriosclerosis and Dementia Syndrome Identifies Signatures of Fibrosis, Angiogenesis, and Metabolic Alterations

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of vascular cognitive impairment and dementia. A genetic arteriolosclerotic disease, the molecular mechanisms driving vascular brain degeneration and decline remain unclear. With the goal of driving discovery of disease-relevant biological perturbations in CADASIL, we used machine learning approaches to extract proteomic disease signatures from large-scale proteomics generated from plasma collected from three distinct cohorts in US and Colombia: CADASIL-Early (N = 53), CADASIL-Late (N = 45), and CADASIL-Colombia (N = 71). We extracted molecular signatures with high predictive value for early and late-stage CADASIL and performed robust cross- and external-validation. We examined the biological and clinical relevance of our findings through pathway enrichment analysis and testing of associations with clinical outcomes. Our study represents a model for unbiased discovery of molecular signatures and disease biomarkers, combining non-invasive plasma proteomics with clinical data. We report on novel disease-associated molecular signatures for CADASIL, derived from the accessible plasma proteome, with relevance to vascular cognitive impairment and dementia. http://dlvr.it/T4qfMD

[daiyunwang-cn]

有遗传病史，三代试管可以筛查吗？广州代孕医院分享~

全世界遗传性疾病有 4000余种，目前通过使用第三代试管婴儿技术，能筛选甄别和检测的遗传性疾病达确定的多达100种，具体有以下疾病：

1、ABO血型不相容

2、超免疫球蛋白M

3、阿拉吉��综合征

4、软骨发育低下

5、阿尔珀斯疾病

6、低磷酸酯酶

7、阿尔法1抗胰蛋白酶

8、低磷软骨病

9、a-地中海贫血

10、色素失调症

11、奥尔波特综合征

12、小儿神经轴素营养不良

13、反凯尔抗体

14、青少年神经蜡状脂褐质

15、贝克肌营养不良

16、青少年视网膜

17、β-地中海贫血

18、小儿神经晚（巴滕病蜡状褐）

19、脸裂下垂内眦 皮反应

20、洛韦oculocerebrorenal综合症

21、乳腺癌，基因1

22、马凡氏综合征

23、乳腺癌，基因2

24中链酰基辅酶A脱氢酶缺乏症

25、氨基甲酰磷酸合成酶缺乏症

26、甲状腺髓样癌（RET）

27、中央核心疾病

28、异染性脑白质营养不良

29、脑动脉（CADASIL）

30、黏多糖症第三B

31、腓骨肌萎缩症1A

32、多发性内分泌腺癌2A

33、腓骨肌萎缩症1B

34、遗传性骨软骨瘤病

35、慢性内芽肿病（CGD）

36、强直性肌营养不良症

37、先天性肾上腺皮质增生症

38、肌管性肌病

39、先天性异常糖基化

40、指甲髌骨综合征

41、先天性肾病综合征

42、杆状体肌病

43、间隙连接蛋白26

44、肾性尿崩症

45、克里格勒性黄疸综合征

46、1型神经纤维瘤

47、克鲁宗合征

48、2型神经纤维瘤病

49、囊性纤维化

50、诺里病

51、捷克发育不良

52、眼皮肤白化病

53、代-索二氏综合征

54、Ornitrine转移酶缺乏症

55、杜氏肌营养不良症

56、成骨发育不全1型

57、早发性阿尔茨海默病

58、掌跖角化过度

59、早发性扭转性肌张力障碍

60、彭德菜综合征

61、上皮细胞钙粘蛋白

62、臂间倒位的X

63、外胚层发育不良

64、多囊肾病，常染色体显性遗传，基因1

65、埃默里斯德雷菲斯肌营养不良症

66、多囊肾病，常染色体显性遗传，基因2

67、大疱性表皮松解，优势营养不良

68、多囊肾病，常染色体隐性

69、大疱性表皮松解，赫利茨交界，基因1

70、近端肌强直性肌病

71、大疱性表皮松解，赫利茨交界，基因2

72、银屑病，晚感基因

73、掌跖角化表皮

74、肺泡蛋白沉积症

75、面肩肱型肌营养不良症

76、视网膜母细胞瘤

77、家族性腺瘤性息肉病

78、恒河猴D疾病

79、家族肌萎缩侧索硬化症（葛雷克氏症）

80、塞-科二氏综合征：尖头并指（趾）畸形综合征Ⅲ型

81、费希特���综合征

82、山德霍夫氏病病

83、脆性X

84、镰状细胞性贫血

85、延胡索不足

86、辛普森Golabi Behmel综合征

87、半乳糖血症

88、痉挛性截瘫

89、Gauchet病2型

90、脊髓性肌萎缩1

91、葡萄糖6磷酸脱氢酶

92、脊髓性肌萎缩症2

93、肝糖储积症1b

94、脊髓性肌萎缩3

95、囟门早闭综合征

96、斯蒂克勒综合征

97、基底细胞综合征

98、甲状腺癌

99、血友病甲

100、易位-各

101、血友病乙

102、转体淀粉样变性

103、遗传性非息肉结肠癌2

104、下颌面骨发育不全

105、遗传性球形红细胞增多症

106、结节性硬化症，基因1

107、先天性巨结肠病

108、结节性硬化症，基因2

109、HLA的维斯科特-奥尔德里奇比赛综合征

110、乌尔里希先天性肌营养不良

111、乙型地中海贫血HLA的匹配

112、卵黄状黄斑营养不良

113、HLA的匹配钻石布菜克法恩贫血

114、希林二氏病；脑视网膜血管瘤病

115、人类白细胞抗原免疫球蛋白M配合超

116、威母氏原细胞癌

117、组织配型与镰状细胞性贫血

118、威斯科特-奥尔德里奇综合征

119、HLA配型

120、、沃尔曼疾病

121、霍尔特奥拉姆综合症

122、X-连锁肾上腺脑白��营养不良

123、亨特综合症（黏多糖症二A）

124、X-连锁choroideremia

125、亨廷顿病

126、齐薇格综合征

[andarthas-web]

Sounds like Anon might have chillblain Lupus erythematodes.

Corticosteroids and Immunosuppressants can help in such a case. They also might want to get it checked out by a specialist, because it *can* be part of a larger, more serious problem like CADASIL, which is associated with depression, migraines and strokes and RVCL, which is associated with dementia, loss of eyesight and also stroke. (They're all due to changes in the TREX1 gene.)

So I have this weird reaction to cold weather where I can get painful red bumps on my hands, generally my fingers. It isn't contagious and generallygo within 3 weeks. Now I work retail, and I'm not supposed to wear gloves as they're "unprofessional". In the past few days I've had a customer demand to know what's wrong with me and another customer ask my manager to send me home for "having chickenpox" despite the bumps not looking like chickenpox spots other than being red and not having then anywhere other than two fingers at the moment.

[lostandfouundd]

CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).

The most common symptoms are:

✔️Recurrent ischemic strokes (transient ischemic attack/stroke) in adulthood that may lead to severe disability such as an inability to walk and urinary incontinence. The average age at onset for stroke-like episodes is 46 years. Transient ischemic attacks and stroke are reported in approximately 85% of symptomatic individuals

✔️Progressive cognitive decline with dementia developing in about 75% of affected people including significant difficulty with reasoning and memory

✔️Migraine, usually with aura, as the first symptom in the third decade of life

✔️Psychiatric problems such as mood disturbances (apathy and depression), presenting in about 30% of people with CADASIL

✔️Seizures with epilepsy is present in 10% of affected people and usually presents at middle age

✔️Diffuse white matter lesions and subcortical infarcts on neuroimaging.

Source:

https://ghr.nlm.nih.gov/condition/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy

https://rarediseases.info.nih.gov/diseases/1049/cadasil

[ravidbmr]

Global CADASIL treatment market is expected to grow at a steady CAGR in the forecast period of 2019-2026. Emergence of drugs used to treat risk associated with CADASIL such as migraine and high demand of disease specific novel therapies are the key factors that fueling the market growth.

For more info@ https://bit.ly/39zRKAr 

[marketreserchnews]

https://www.databridgemarketresearch.com/reports/global-cardasil-treatment-market

[mucillo]

Guarda "CHE COS'E' PER VOI LA DIGNITA'? FINALE MAR ADENTRO" su YouTube

Mare dentro: la poesia di Ramón Sampedro

Toccante e bellissima è la poesia che dà il titolo al film di Amenábar, che di seguito riportiamo integralmente:

Mare dentro, mare dentro,

senza peso nel fondo,

dove si avvera il sogno:

due volontà fanno vero un desiderio nell’incontro.

Un bacio accende la vita

con il fragore luminoso di una saetta,

il mio corpo cambiato

non è più il mio corpo,

è come penetrare al centro dell’universo.

L’abbraccio più infantile,

è il più puro dei baci,

fino a diventare un unico desiderio.

Il tuo sguardo, il mio sguardo,

come un’eco che ripete senza parole:

più dentro,

più dentro,

fino al di là del tutto,

attraverso il sangue e il midollo.

Però sempre mi sveglio,

e sempre voglio essere morto,

per restare con la mia bocca

preso nella rete dei tuoi capelli.

La poesia è dedicata a Julia, la donna amata da Ramón, avvocatessa che lo sostenne nella sua battaglia e anch’essa afflitta da una malattia degenerativa, la CADASIL.

[saraozs]

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy)

The name of the disease says it all.

One of the shortest sad stories.