#but holy shit these two ?????

[moomeecore]

wobbly rooms

[chloesimaginationthings]

FNAF Phone guy was wild for saying that to Michael..

[eightbitpale]

They ran a guy over :(

[dirtgrubber]

unhinged short king vs eldritch terror with dorky accent

pose ref @mellon_soup

[jestroer]

Guys, there are. Two shadow people on the new banner

[nyancrimew]

new blog post:

[lukellios]

What a difference six years makes

[carnivalcarriondiscarded]

world's longest staring contest GO-

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[ijustcamefortheships]

No because I was so prepared for Jayce and Viktor to have a nasty ass divorce arc where they end the series despising each other on opposite sides of a war. And instead we got this incredibly complex relationship where yes they disagree for a time and maybe try and kill each other. But also they care so deeply for each other and their fates are intertwined throughout all of space and time. Where they never truly give up on each other. Where they both choose the right path in the end and do so together, hand in hand.

[stump-not-found]

silly guy

[faerieomenart]

I never shipped Jayce or Viktor and only joked about it based on memes from season 1; however, after finishing the last act of season two... ya'll were right. Those mfs gay.

[thebibliosphere]

Reblogging polls with Hunger Pangs still makes me anxious in case people get mad that I’m skewing the results (had some people get really angry at me over that this last year) but I’m genuinely sincere when I say I love learning about new queer media to enjoy and inevitably end up reblogging it anyway because I want other people to know about i and enjoy it too.

I couldn't give less of a fuck about the poll results. I’m just amazed and so, so happy to be alive in a time where we have enough openly queer media we get to choose.

Do you know how precious that is?

[stripedstarsblueflags]

jesus CHRIST can these two make ONE e-sports video that’s not straight up porn

seriously ferrari had NO RIGHT to post this because in this singular clip we have

1) carlos leaning over charles with one hand on the steering wheel platform and the other arm draped over his headrest

2) carlos continuously encouraging and complimenting charles as he concentrates

3) carlos CHECKING IN with charles

4) charles being confident in himself and just preening under the praise

5) carlos mentioning something very specific about why charles is doing so well

6) charles responding with dazed eyes slack jaw softest murmuring voice “carlos…”

7) carlos checking in again “you know what i mean?” and charles’s voice dropping into barely a whisper “yes”

guys we just witnessed carlos accidentally sending charles tumbling headfirst into an absolute ABYSS of subspace and ferrari broadcasted that to the world

[munsonfamilyband]

I need more famous musician Eddie content where he’s still super fucking lame and freaks out around other musicians

Like, I’m thinking about the video of JQ getting to meet with Metallica and play with them and Hetfield asks if he wants them to sign the guitar and Joseph gets so excited about it.

Eddie at an after party or something and he left Steve (and Robin because she refused to not be invited if Steve was coming (he gave her a “job” just so she could come)) to go get them some drinks and when he comes back Steve is talking to Brian May like he’s just a normal guy. Steve had been talking to Robin about Dustin getting an internship at NASA and Brian May inserted himself so he could ask about Dustin’s job.

Eddie comes over, nearly vibrating, and Steve introduces him to “Brian, he’s an astrophysicist!” and Eddie nearly passes out when he shakes his hand as if this isn’t a member of Queen.

It becomes a theme for them at events where Steve makes conversation with these world famous musicians about real life things all while Eddie is trying to act like a normal person standing in front of James fucking Hetfield.

The eventually develop a way for Eddie to subtly signal to Steve that this is one of his heroes so that Steve can steer the conversation to music and give Eddie an in.

I just need more social butterfly Steve and his music nerd boyfriend Eddie who panics whenever Steve befriends a famous person.

[kettlefire]

As Good as Good Gets (DP X DC Snippet)

Richard "Dick" Grayson is the golden child. In the eyes of the public, and in the eyes of the league. Dick is a sweet, caring son, a man who went from being a sidekick to being a hero. The pipeline from Robin to Nightwing had many people applauding his dedication to keeping Gotham safe.

No one knew the full story, not truly. No one but Bruce Wayne himself. And maybe a certain butler. Many don't know that Dick only became Robin to stop him from hunting down and killing the man who killed his parents.

No one really knows about the harsh fights and arguments he has had with Bruce. The times when Dick would find himself cut off from the Wayne name for a week or so. No one knows that the first person Dick warmed up to was Alfred. Having been bribed with cookies.

Things weren't always this good, trusting, happy relationship between Bruce and Dick. It had been a rough ride, a complicated one. But that was okay, because it got better.

Dick stopped being so moody and angsty. He grew up, he learned, and he changed. He became an older brother, found people that needed him. Needed him in a way that the citizens of Gotham didn't need him.

His brothers like to call him annoying. A goody two shoes who Bruce trusted more than everyone else. They couldn't fathom how someone like Dick could be so stupid and bubbly at all times.

All times, except when shit hits the fans. Despite the name calling, despite coining Dick as the stupid Wayne. They all knew better. They knew that when it mattered, Dick Grayson always pulled through. He was a force to be reckoned with when needed.

The whole Wayne family was a force to be reckoned with when called for. It didn't have to be under the guise of costumes and vigilante acts. Whether he was Officer Grayson or Nightwing, Dick was a man with his morals and values.

One night on patrol as Officer Grayson, Dick found someone who needed that force. A force willing to protect and care for the innocent. The hurt. The damaged, yet still good.

It started like any other night. A call of shots fired by an empty warehouse. There was no sighting or knowledge of any rouges being there, so Dick took the call. Told the team he'll contact them if it seems more than just a civilian incident.

The warehouse was dark, reeked of copper and oil. It didn't take long for Dick to find the trail. The liquid he found looked like the person had been dragged before walking. There was a clear struggle, even with the mess and emptiness that was the warehouse.

That wasn't Dick's biggest concern. The concern lay in just how much blood there was. Too much for any normal person to lose and still manage to stumble through the warehouse.

It wasn't just blood. It wasn't that much, but Dick could spot the strangeness in the liquid. The mixed in green that had an eerily similar color and glow as a certain pit.

Without thinking, Dick followed the trail. Barely remembering to make contact with his family. Give them an update on what he found. Words telling him to stay put for backup went in one ear and out the other.

Something in Dick's gut was telling him he couldn't wait. He needed to find the source. Whoever was currently bleeding out in this warehouse. He silenced the comm, moving further through the dimly lit building.

Then Dick found it. Or more so, he found him. It was just a boy. A boy that reminded Dick too much of the youngest Wayne. A boy sat against a wall, looking pale and weak.

Red and green coated the front of the boy's shirt, arms wrapped tightly around his middle. An attempt to stem the bleeding. A puddle had already started to form beneath the boy, and Dick moved without thinking once again.

He quickly found himself kneeling beside the boy, hands carefully reaching out. Before Dick even touched him, the boy flinched. Eyelids suddenly opened, wide and terrified blue eyes landed on Dick's.

In just that one look, Dick knew what he had to do. The haunting, terrified, and pained look in the boy's eyes told Dick everything he needed to know. The boy was in danger. Someone had hurt this kid, and it was clear it wasn't the first time.

The boy struggled weakly against Dick's touch, terrified whimpers, and barely coherent pleas spilled from the kid's lips. It had Dick's heart aching, clear as day the poor kid has been through hell and back.

It took a lot of reassurance, gentle touches, and promises of help before the kid let Dick take a look at the bleeding wound. A promise on Dick's soul had been the final thing that earned him any semblance of trust. A strange promise, but Dick was willing to make it.

That concern turned to pure anger the moment Dick managed to pull the sticky shirt away from the wound. The sight of a Y-incision cut perfectly into the skin, stitches tight on the skin, but blood still leaking heavily from the wound.

It didn't take long for Dick to realize why. Despite the perfect surgical care of the wound, a good couple of stitches had broken. Leaving gaping spots for that red and green liquid to pour out of.

The boy was deathly silent, tears streaking down his cheek as wide blue eyes stayed trained on Dick. In that moment, Dick knew he had to help. Had to get the kid to safety, patch him up, and find out what kind of monster would do this.

It didn't matter if the kid was human or not. It didn't matter if the kid had special abilities or not. No one, absolutely no one, deserved to be vivisected.

The kid was shrouded in mystery, but that mystery only seemed to grow and become clearer when Bruce had entered the scene. The boy had tensed, eyes flashing a bright glowing green.

Lazarus pit green.

It set a pit of dread in Dick's gut. His mind brings forward memories of Jason. Jason, after his revival, after his dip in that cursed pit. The same flash that his brother would get if he got too angry. Too emotional.

As much as Dick wanted to focus on finding who did this, if it had any connection to Ra's al Ghul. He couldn't. Not when the kid tried to get up, to pull away as Bruce and the others made their way closer.

Right now, Dick only cared about making sure the boy was okay. Fixing those stitches, getting him a meal, and a warm bed.

He needed to get this kid someplace where he felt safe and secure. Comfortable and protected. Dick wasn't sure why. Maybe it was the promise he had made, but he wasn't letting anyone get to the kid.

That included his family. As strange as it seemed, Dick put himself between the others and the kid. Shooting them all a glare that they had only ever seen a handful of times.

Dick lifted the poor boy up in his arms, cradling the crying child close as he led the way out of the warehouse. Ignoring the questions or confusion coming from Bruce and the others. As Dick walked, feeling the trembling boy clinging to him, he made a rather obvious realization.

Maybe the eldest son really was more like Bruce than he expected. Just a few short moments the the boy, a boy that Dick didn't know his name, and he was ready to pull out adoption papers. To give the boy a safety he so desperately needs.

Give him the chance that Bruce had given him all those years ago.