#but holy shit these two ?????

[moomeecore]

wobbly rooms

[chloesimaginationthings]

FNAF Phone guy was wild for saying that to Michael..

[eightbitpale]

They ran a guy over :(

[ijustcamefortheships]

No because I was so prepared for Jayce and Viktor to have a nasty ass divorce arc where they end the series despising each other on opposite sides of a war. And instead we got this incredibly complex relationship where yes they disagree for a time and maybe try and kill each other. But also they care so deeply for each other and their fates are intertwined throughout all of space and time. Where they never truly give up on each other. Where they both choose the right path in the end and do so together, hand in hand.

[dirtgrubber]

unhinged short king vs eldritch terror with dorky accent

pose ref @mellon_soup

[miyoshi81194]

HOLY SHIT THIS IS EVERYTHING TO ME 😭😭😭

[jestroer]

Guys, there are. Two shadow people on the new banner

[nyancrimew]

new blog post:

[lightbulb-warning]

WOOOOOHOOOOO this is my @isat-secretsanta-2024 gift for @mintbearjr!! drinking buddies!! HAP NEW YEAR!!! :D

[potato-lord-but-not]

when when the first day of Hanukkah is on Christmas ough ough ough

[lukellios]

What a difference six years makes

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[stump-not-found]

silly guy

[thebibliosphere]

Reblogging polls with Hunger Pangs still makes me anxious in case people get mad that I’m skewing the results (had some people get really angry at me over that this last year) but I’m genuinely sincere when I say I love learning about new queer media to enjoy and inevitably end up reblogging it anyway because I want other people to know about i and enjoy it too.

I couldn't give less of a fuck about the poll results. I’m just amazed and so, so happy to be alive in a time where we have enough openly queer media we get to choose.

Do you know how precious that is?

[edelgards]

this game is so unreal to me i'm not going to lie

[stripedstarsblueflags]

jesus CHRIST can these two make ONE e-sports video that’s not straight up porn

seriously ferrari had NO RIGHT to post this because in this singular clip we have

1) carlos leaning over charles with one hand on the steering wheel platform and the other arm draped over his headrest

2) carlos continuously encouraging and complimenting charles as he concentrates

3) carlos CHECKING IN with charles

4) charles being confident in himself and just preening under the praise

5) carlos mentioning something very specific about why charles is doing so well

6) charles responding with dazed eyes slack jaw softest murmuring voice “carlos…”

7) carlos checking in again “you know what i mean?” and charles’s voice dropping into barely a whisper “yes”

guys we just witnessed carlos accidentally sending charles tumbling headfirst into an absolute ABYSS of subspace and ferrari broadcasted that to the world