#as is Tang Hanqiu

[mxtxfanatic]

Book of the Week: She Is the Protagonist

Author: Re Dao Hun Jue (热到昏厥)

Genre: transmigration, rebirth, modern-day showbiz, baihe

Rating: T

My Synopsis: Tang Hanqiu has finally managed to free herself from the control of her system after throwing herself off the edge of a building in her first life. On the other side, Yu Rubing has discovered that her system is a little bit more stubborn with her refusal to play along. When the fated "love rivals" meet, they both take it as a chance to finally thwart the beings trying to control their lives, but will they successfully escape the shackles of systems hellbent on charting out their life course?

My Actual Review: As the first and currently only baihe that I have read, finished, and thoroughly enjoyed, I absolutely love this story. Yu Rubing is a character that takes no shit from the moment she wakes up as the protagonist, and her team-up with Tang Hanqiu matches both of their energies so well. Also, the romance is so perfect. I must say I am a sucker for characters who realize their affections early on and get together before the final arc of the story. The surprise (surprise?) villain was honestly kinda terrifying when paired with the rules of the world(s) that the characters were unknowingly living under, and I hope that the author writes another novel set in this very same universe because the drama behind the system was fascinating. Also, loved the extras! I love when the main couple has children! I feel like I should add this as a content warning, but both MCs commit suicide multiple times throughout the story but as ways to escape the control of the system and not as an expression of a wish to die.

The translation is alright. It's a little clunky in places, and I was definitely annoyed by translation notes that just felt like I was being walked through every single metaphor (even ones that are common in English!) but it is by far one of the better-quality translations to read.

Translation: complete

[cancersfakianakis1]

Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

Publication date: 11 December 2017 Source:Cancer Cell, Volume 32, Issue 6 Author(s): Hanqiu Zheng, Yangjin Bae, Sabine Kasimir-Bauer, Rebecca Tang, Jin Chen, Guangwen Ren, Min Yuan, Mark Esposito, Wenyang Li, Yong Wei, Minhong Shen, Lanjing Zhang, Nikolai Tupitsyn, Klaus Pantel, Chadwick King, Jan Sun, Jodi Moriguchi, Helen Toni Jun, Angela Coxon, Brendan Lee, Yibin Kang Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1 represents a central node in mediating tumor-stromal interactions that promote osteolytic bone metastasis. Here, we report the development of a highly effective fully human monoclonal antibody against Jagged1 (clone 15D11). In addition to its inhibitory effect on bone metastasis of Jagged1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells. We further confirm the bone metastasis-promoting function of osteoblast-derived Jagged1 using osteoblast-specific Jagged1 transgenic mouse model. These findings establish 15D11 as a potential therapeutic agent for the prevention or treatment of bone metastasis.

Graphical abstract

Teaser

Zheng et al. develop 15D11, a fully human monoclonal antibody to Jagged1, which inhibits Jagged1 on breast cancer cells as well as blocking metastasis-promoting effects of osteoblast-derived Jagged1 induced by chemotherapy. 15D11 reduces bone metastasis and sensitizes metastases to chemotherapy in mouse models of breast cancer. http://ift.tt/2jwoXqJ