#antitumorigenic

[phytoceuticalsskincare]

The Best Vitamin C Serum to Reduce Photo-Damage

Many people suffer from photodamage because of prolonged exposure of their skin to solar radiation. It could result in the degradation of collagen. You could also suffer from skin cancer. You will also suffer from hyperpigmentation, reduced skin elasticity, wrinkles, neoplasms, actinic keratoses, and telangiectasias because of increased exposure to sunlight. To avoid all these side effects, you should avoid exposure to harsh sunlight, mainly between 10 AM and 12 PM.

Treatment for photodamage

You can choose proven Phyto-C selenium Vitamin C Cream, such as Selenium in C Serum, to diminish the photodamaged appearance. The powerful antioxidant formula in this serum also acts to reduce the appearance of aging signs like wrinkles and fine lines. People with combination, natural, and combination skin types can use this serum to diminish aging signs and photodamage.

The Selenium in C Serum is manufactured using ingredients like Chromium, Glycoside, Selenium, L-Ascorbic acid, Vitamin B5, Alpha tocopherol, Retinol, Vitamin B12, and water. All these ingredients are mixed using an advanced formula to cure skin conditions like dull skin, uneven skin tone, and advanced signs of aging. It is the best selenium vitamin C cream to reduce dark spots on your skin and help you enjoy a bright and youthful-looking complexion. It also corrects your rough skin texture and removes fine lines. It also improves the appearance of acne blemishes. You will enjoy an improved skin complexion by regularly using this skin care cream.

L-ascorbic acid aids collagen synthesis

Vitamin C, or L-ascorbic acid, is 15% of this cream. It plays a vital role in collagen synthesis. It is highly useful for photoprotection. It reduces photodamage and promotes quick healing of wounds. When it is combined with Vitamin E, you can avoid ultraviolet light-induced damage to your skin. It also plays an essential role in reducing wrinkles caused by aging.

You should avoid smoking, as it leads to reduced collagen synthesis and wrinkles on your skin. So, you need to make lifestyle changes along with regularly using selenium vitamin C cream to heal photodamage and get rid of aging signs.

Alpha-tocopherol helps retain moisture and maintain healthy and radiant skin. It is also called vitamin E. This fat-soluble antioxidant protects your skin from deleterious effects caused by solar radiation. It scavenges free radicals. It has photoprotective and antitumorigenic properties. Apart from applying selenium vitamin C cream to your skin daily, you can also include olive oil, nuts, whole grains, spinach, and sunflower oil in your daily diet.

Selenium and zinc are essential for people suffering from acne. Selenium keeps your skin firm. It inhibits the damage caused to your skin by free radicals. So, it prevents premature wrinkles on your skin. You will also get protection from inflammation, UV damage, and pigmentation. Besides using selenium vitamin C cream regularly, you need to include foods like lentils, brown rice, chicken, turkey, prawns, tuna, potatoes, peas, Brazil nuts, pumpkin seeds, flax seeds, and lobster in your daily diet to maintain blemish-free skin.

  You can buy Selenium in C Serum from a reputed e-commerce store. You can avail yourself of a 10% discount on your next purchase by subscribing to a newsletter at an e-commerce site. You are also advised to practice mild walking and jogging exercises daily and ensure sound sleep.

[cbdinternationalcompany]

How Cannabis Oil Works to Kill Cancer

Ground breaking nations have perceived the recuperating advantages of cannabis. The latest enactment of restorative and sporting weed authorization was in Canada in October 2018.

The endorsed activity of retail locations this year in probably the greatest city in the nation, Ontario, has demonstrated that a ton are agreeable to this top notch plant. Buyers are not, at this point restricted in buying from mail-request cannabis conveyance administrations, for example, Get Kush dispensary.

On top of this, makers have additionally been pushing this promotion at a most extreme. Different subsidiaries of cannabis plants, for example, cannabis oil are causing a ripple effect in the health care industry. The effective capacity of cannabis oil in relieving a few health issues like epilepsy, ongoing pain, irritation, nervousness, diabetes, neurological problems, and even malignant growth won't ever go undetected. Visit cbd-international.net and checkout how CBD oil helps in cancer treatment.

Is Cannabis Oil Legal?

As indicated by the Controlled Substances Act, all subordinates of cannabis with zero to under 0.3 percent THC (delta-9-tetrahydrocannabinol) are viewed as legitimate. Cannabis plants may fluctuate in THC and CBD content. So relying upon the plant source, cannabis oils which have zero to under 0.3 percent are satisfactory.

The power of cannabis oil will shift on the source and extraction technique too. Some extraction strategies are secludes extraction, liquor extraction, or CO2 extraction. Removing from an entire cannabis plant which has a CBD-prevailing substance is said to have the best return of cannabinoids.

While getting the higher finish of the range from extraction, this profoundly strong cannabis oil can connect with the body?s endocannabinoid framework. The endocannabinoid framework has an inseparable tie to the guideline of various body capacities including mind-set, conduct, hunger, pain, rest, energy, and then some. Moreover, the endocannabinoid framework is additionally liable for cell development and apoptosis.

Also, since disease is because of the unusual expansion and change of cells, the restorative cannabinoids in cannabis oil is known to help slaughter strange malignant growth cells particularly in the beginning phases of malignancy.

How CBD Oil Helps in Apoptosis

Apoptosis is a characteristic cycle in the body where the cells are annihilated as a component of a specific organism?s development. As referenced, malignancy cells develop as a strange cycle in the body since they presently don't recognize the body?s signals that support or annihilate cell development.

As these cells develop and partition, they become more wild. Furthermore, since they presently don't react to apoptosis, they will in general speed up cell expansion and overlook different signs from ?ordinary cells.? That is the reason the endocannabinoid framework is a critical framework in the body since it additionally helps in adjusting cell development and passing.

As malignant growth cells replicate quicker than the endocannabinoid framework can deal with, the disease cells attack through the typical tissues and spread all through the body. This interaction is called metastasis.

The endocannabinoid framework has two essential receptors. One is the CB1 receptors which are generally found in the cerebrum, and the other one is the CB2 receptors which are fundamentally found in the resistant framework.

THC is the dynamic compound in cannabis that predicaments to the CB1 receptors and is answerable for mind-set, conduct, and other cerebral capacities. Then again, CBD hooks onto the CB2 receptors and tells these receptors if there are ?trespassers? that are impeding to the body.

The apoptotic cycle by these receptors is accomplished through the anew combination of ceramide and sphingolipid that advance cell annihilation.

When they tie together, the receptor initiation would then be able to help the endocannabinoid framework in flagging an antitumorigenic cautioning. Which implies, it disables malignant growth improvement through repressing multiplication, metastasis, and tumor angiogenesis.

End

Albeit further investigations presently can't seem to be looked into to demonstrate these cases, the cannabinoids in cannabis oil have evidently helped malignancy patients somehow. Chemotherapy patients have additionally gone to cannabis oil for easing their post-chemo results like sickness, regurgitating, weariness, aggravation, neuropathic pain, invulnerable concealment, and loss of craving.

[didanawisgi]

Abstract

Colorectal cancer is one of the most common causes of cancer-associated mortality worldwide, but it is truly a preventable disease. Both curcumin and boswellic acids are well-established dietary botanicals with potent antitumorigenic properties that have been shown to modulate multiple oncogenic pathways. Recent data suggest that the chemopreventive effects of these botanicals may, in part, be mediated through regulation of key cancer-related microRNAs (miRNA) and their downstream gene targets. Here, we investigated the antitumorigenic effects of curcumin and 3 acetyl-11-keto-β-boswellic acid (AKBA) on modulation of specific cancer-related miRNAs in colorectal cancer cells and validated their protective effects in vivo using a xenograft mouse model. Both curcumin and AKBA inhibited cellular proliferation, induced apoptosis and cell-cycle arrest in colorectal cancer cell lines, and these effects were significantly enhanced with combined treatment. Gene-expression arrays revealed that curcumin and AKBA regulated distinct cancer signaling pathways, including key cell-cycle regulatory genes. Combined bioinformatics and in silico analysis identified apoptosis, proliferation, and cell-cycle regulatory signaling pathways as key modulators of curcumin and AKBA-induced anticancer effects. We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells. Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings. Herein, we provide novel mechanistic evidence for the chemopreventive effects of curcumin and AKBA through regulation of specific miRNAs in colorectal cancer.

[alfafoods]

Is Ragi Good for Diabetes? Find Out.

In current times, a boost in the spreading of way of life conditions like hypertension, weight problems, and diabetes has actually led us to a section. It has become important to avoid ourselves and our adored ones from encouraging these health and wellness problems as well as handling way of life disorders. Folks have actually used different foods items with higher dietary homes that exhibit antioxidant and also anti-inflammatory attributes

Ragi is among the meals people conform to due to the bioavailability of vitamins and minerals as well as its own a variety of health perks. Nutritional experts propose that the consumption of ragi is actually incredibly beneficial for individuals along with excessive weight or diabetic issues. Permit's learn about ragi as well as its own uses in combating lifestyle disorders.

Ragi as well as its Kind

Ragi is actually a staple food surface planted largely in far eastern and main Africa as well as southern portion of India. It is increased in completely dry, very hot climates as well as at high altitudes and also is actually additionally referred to as hands millet.

This is since the head of the grain includes five spikes in a leaning way from the central idea like fingers attached to the hand. The measurements of the ragi differs from 1-2 mm. It can be found in different colours, from reddish to sometimes white colored as well as dark. It has a higher fiber and calcium mineral material than any other grains. Ragi is actually a really good resource of health and nutrition for developing youngsters, expecting women, aged people, and also clients encouraging different metabolic health conditions. Given that of the wealthy volume of calcium, phytochemicals, and also phenolic materials located in Ragi, it is.

These compounds make it easy to sum up. Folks generally utilize it in meal plannings to make pudding, dumplings, chapati, sprouted, or even steamed ragi meals.

In addition, it has been gaining importance as a result of its own little by little digestible starch and also resisting carbohydrate, which maintains the body fuller as well as manages blood sugar degrees.

Also, take ideas from our previous blog on: Mosambi Juice for Weight Loss? Try it Today

Nutritional Properties of Ragi.

Ragi is a nutrient-dense millet and also is extra healthy than many grain grains. It consists of an enormous amount of calcium mineral, iron, diet fibre, vital amino acids, as well as various other minerals.

It is actually wealthy in phenolic compounds as well as phytochemicals, which exhibit higher antioxidant activity. Together with this, it contains high-quality healthy protein, vitamin A, B complex, as well as phosphorus. It is an abundant source of methionine, isoleucine, leucine, phenylalanine, and other necessary amino acids.

The Nutritional Market value of ragi is actually according to 100g performing:

Power: 336 kcal

Healthy protein: 7.7 gm

Excess fat: 1.5 gm

fibre: 11.5 gm

Carbohydrate: 72.6 gm

Calcium: 350 mg

Iron: 3.9 milligrams

Magnesium mineral: 137 milligrams

Phosphorus: 283 mg

Manganese: 5.94 milligrams

Blood potassium: 408 mg

Beneficial Quality of Ragi

Ragi has abundant phytochemicals that enhance its own nutraceutical homes. Therefore, it delivers a multitude of health and wellness perks. It possesses numerous useful and also nutritional qualities such as anti-diabetic, mainly to cope with type 2 diabetic issues mellitus, anti-inflammatory, anti-diarrhoeal, anti-ulcer, as well as antitumorigenic features.

Other such properties are anti-microbial, antioxidant, as well as atherosclerogenic impacts. However, research studies have shown that intake of ragi has actually decreased due to lack of knowledge regarding its nutritional wellness perks. However, it has modified due to the fact that folks began to use alternate consuming approaches.

Wellness Conveniences of Ragi

Hands millet consists of prospective phenolic compounds disclosed to exhibit antioxidant task. These antioxidants have free of charge radical scavenging activity as well as work as a prospective prevention of organic oxidation, which aids protect against conditions related to way of life ailments. Phenolic substances existing in ragi prevent the beginning of problems in a variety of health and wellness disorders including cardiovascular disease and cancer. Its antioxidant tasks might also help in delaying the development of ageing signs.

Research studies present that hands millet may inhibit bovine collagen crosslinking, which decreases the aging process by decreasing the rigidity of flexible cells in tendons, skin, and also blood vessels.

Higher Calcium Web Content

Ragi contains polyunsaturated fats including linoleic as well as linolenic acid. It assists in the typical advancement of the core nerves. In addition, it is a source of calcium, with up to 350 mg/100 g of calcium present in the seeds.

Its calcium mineral web content is actually 5-10 times greater than some others grains; even cow's milk has 112 mg/ one hundred g of dairy. The lack of lactose sweets in ragi makes it simply digestible and markets optimum calcium mineral absorption.

It is a suitable food items surface for discouraging infants, lactose-sensitive folks, increasing little ones, seniority for bone mass advancement, as well as to handle other bone tissue ailments including brittle bones.

Avoiding Cardiovascular Disorders

Cardiovascular problems have come to be the key source of globally death. Unusual high blood pressure, raised cholesterol degrees, hypertension, depression, diabetes, and also weight problems are actually critical elements that worsen cardiac ailments. Eating a millet diet plan has actually shown a substantial decline in serum triglycerides and total cholesterol amounts.

Files advise that phenolic compounds located in hands millet lesser lipid peroxidation and hinder oxidative adjustment of LDL cholesterol levels. Consequently, it reduces the occasions of coronary artery disease, essentially minimizing the threat of heart attacks and also strokes. Furthermore, the soluble fibre in ragi likewise decreases the reabsorption of bile acids as well as LDL cholesterol.

Perfect for Celiac Illness

In latest opportunities, the incidence of autoimmune problems has improved dramatically. When consumption of a team of proteins named wheat takes location, celiac health condition is one of the very most common autoimmune conditions triggered. Barley, wheat or grain, and also rye grains primarily have wheat.

It is necessary to steer clear of gluten-containing foods as well as comply with the meals options with comparable nutrient properties to maintain celiac disease. Rice, corn, sorghum, quinoa, amaranth, millet, and oats are actually cereals mentioned to possess non-glutinous attribute.

Boosts Bowel Movement

Ragi is abundant in soluble and insoluble diet fiber and roughage that is not broken throughout digestive function, boosting the satiety level. Studies have revealed that fibre aids protect against food poisonings, bowel cancer cells, coronary cardiovascular disease, as well as diabetic issues. The insoluble fiber part of ragi helps mass the stool by preserving water in faeces.

It functions as a healthy laxative that induces digestive tract mobility and also stops irregular bowel movements through advertising peristalsis. Soluble fiber element aids in lubrication and soothing of the inflamed digestion system. It reduces peptic irritation and displays anti-ulcerative residential or commercial properties.

Hands millet has top notch protein along with a high portion of important amino acids and also bioactive peptides, which assists manage protein-energy poor nutrition and deal with homeostasis in different conditions. Finger millet is a quickly absorbable and strongly well balanced surface best for undernutrition and also being overweight teams. It contains tryptophan, valine, and methionine, scarcely present in vegan diet regimens. In addition, it possesses low-fat material, making it excellent for overweight individuals.

Researches have shown that hands millet carbohydrate structure is actually gradually absorbable and also takes longer to absorb. Because of this, it improves the satiety amount, lessens excessive calorie consumption, as well as prevents appetite pains, marketing fat burning.

Deterrence from Cancer

To reduce cancer occurrence, people switch to far healthier meals choices than refined options. Incorporating meals alternatives to the nutritional routine that exhibit anti-cancerous properties lowers the frequency of spontaneous as well as chemically generated tumours. Hands millet has phytochemicals and anti-oxidants, which possess substantial anti-carcinogenic residential or commercial properties.

Documents advise that it contains ferulic acid, which occurs to possess shutting out effects on caused carcinogenesis in breast, bowel, and also tongue cancer cells.

Ragi is a nutrient-dense grain along with a lengthy service life and also could be expanded in dry spell locations. Moreover, scientists are actually checking out whether one can easily use millet to combat food insecurity as well as guard the populace throughout climate weakness.

Ragi for Diabetic Issues

Diabetic issues is actually a chronic metabolic disorder diagnosed along with higher blood glucose level degrees because of inadequate creation of insulin or even as a result of the hormone insulin resistance. Finger millet contains phenolic extractions, successful alpha-glucosidase as well as pancreatic amylase preventions. Therefore, it helps manage hyperglycaemic problems. In addition, it is helpful in reducing blood sugar degrees.

Research studies have actually presented that hands millet-based food preparations reveal a lesser glycaemic index, which induces a lesser response. In addition, it shows that adding 30% of millet to multigrain flour has substantially decreased plasma televisions glucose levels. The significant reduce is related to dietary fibre-mediated postponed carb digestibility. A research has actually shown that calcium mineral and also vitamin D consumption worrying type-2 diabetes in women aided relieve the threat. Hands millet possesses a wealth of calcium mineral as well as magnesium, easing diabetic issues type-2 risk not directly.

Among the substantial concerns of diabetic issues clients is the hold-up in injury healing. A 4-week research study has actually discovered that consuming millet speeds up wound recuperation, strengthens antioxidant standing, as well as controls blood sugar degrees. Moreover, incorporating ragi to the diet regimen has been reported to put off the start of cataractogenesis, which is an issue of diabetes.

The healthy protein and lipid web content disrupts starch digestion, which prolongs its own digestive function as well as gets a long period of time for blood sugar launch. As a result, the higher fibre web content of ragi might impact blood sugar degrees to a lesser level than various other processed grains. Regardless, eating high amounts of fibre helps lesser blood glucose amounts and avoids the threat connected with diabetes.

Also, take ideas from our previous blog on: How To Lose Weight Fast: 10 Tips to Shed Kilos the Healthy Way

The Very Best Ways to Take In Ragi for Diabetes Mellitus

Individuals can consume ragi in a variety of types, such as flatbreads, pudding, bakery, and also porridge products. One may utilize it with different surfaces in porridge or even multigrain chapati.

Glycemic mark studies on hands millet plannings vary from reduced to higher market values, conducted along with out-of-date strategy. Appropriate GI testing of hands millet prep work and also brief- and also lasting individual assistance tests might help set up evidence-based wellness perks.

Keep in mind: Folks with renal disorders, thyroid ailments, and also diarrhea needs to stay clear of eating ragi. It negatively affects all of them and also aggravates their disorders.

Conclusion

Ragi is a nutrient-dense crop along with enormous wellness benefits as well as nutraceutical features, which are actually unfamiliar. Consequently, adding ragi with various other staple crops can enhance all-around worldwide wellness status. The health benefits of ragi are dramatically higher because of its own high nutritional high quality. Ragi is actually useful for diabetic person individuals due to its own high nutrient thickness as well as fiber web content. Moreover, it can be consumed safely through diabetic person people as it stabilises blood glucose level amounts as well as eases the swelling and also oxidative worry connected with diabetes. Extra study is needed to identify which kind of ragi is excellent for diabetic person individuals.

It has a remarkably high amount of calcium mineral, more than any other cereal. As a result, expert in nutritions recommend ragi intake for bone tissue advancement and enhancing in infants, expanding children, and aged individuals. Frequently Asked Questions (Frequently Asked Questions).

Q. Just how much ragi should an individual with diabetes take daily?

If the diabetic individual possesses stable blood sugar degrees, a. 10-20 g of ragi may be actually taken in everyday or on alternate days. It is vital to know how to consume ragi so that it will not increase blood stream glucose amounts in a diabetic person. Saturating ragi for 12 hours, stashing ragi moist for 24 hr, or steaming for an hour are actually the very best ways to eat ragi.

Q. Does consuming ragi increase blood sugar level?

A. Despite the fact that ragi possesses a higher glycemic mark, it has an effect on blood glucose degrees to a lesser degree than refined grains. The principal cause behind this is the existence of several anti-nutritional variables and also high fibre content, which increase the blood sugar intake opportunity in the course of digestive function. Because of this, it causes reduced post-prandial blood sugar amounts, as a result low blood glucose amounts.

Q. Who should fast ragi?

A. Individuals who deal with thyroid ailments, diarrhea, and renal disorders like renal rocks. It may affect folks significantly that encourage such problems.

Q. Which flour is actually absolute best for diabetic issues?

A. Generally, flour with high fibre and facility carbohydrates is actually optimal for diabetes. Some flours taken into consideration absolute best for diabetes mellitus consist of ragi flour, Bajra flour, amaranth flour, barley, and Jowar flour.

Q. Is actually arrowroot great for diabetes?

A. Arrowroot is actually a tropical weed along with much more than 80% starch, as well as the continuing to be amount consists of proteins, vitamins, minerals, and also fibre. It has a medium glycemic mark which varies from 65-to 85. It is encouraged certainly not to take in too much arrowroot if the person has diabetic issues.

Q. Is actually ragi carbohydrate or healthy protein?

A. Ragi is actually a millet called hands millet. It has 65-75% of carbohydrates, 15-20% of fiber, as well as 5-8% of protein.

Q. What takes place if you eat ragi daily?

A. Ragi is known for its thick nutrients. Eating ragi day-to-day enriches nerves impulse conduction, promotes an excellent mood, as well as deals with sleeplessness as well as anxiety.

Q. What is the glycemic mark of Ragi?

A. Glycemic mark of ragi indicates whether one may eat it throughout diabetes mellitus or otherwise. The way glycemic mark of millets varies coming from 54-to 68. The GI credit rating of ragi flour is actually 104, while the GI rating of ragi when it is actually dehusked, soaked for 12 hrs, saved moist for 24 hours, and also steamed for one hour is 68.

Q. Does ragi assimilate quickly?

A. Yes, ragi is actually effortlessly digestible because of its own high fiber information, antioxidants, as well as phytochemicals. Because of its high fibre information, it maintains the stomach full for a more lengthy time period. It prevents regular food cravings pangs. It increases the moment needed to absorb glucose in the course of food digestion.

Q. Can I eat ragi during the night?

A. Yes, one may consume ragi in the evening. Ragi consists of an important amino acid called tryptophan which helps handle rest disorders like stress, sleeplessness, and depression. It is fiber-rich food. It is actually required to keep in mind that people along with intestinal complications need to certainly not consume it at night.

Nutritionists suggest that the usage of ragi is actually very favorable for individuals along with weight problems or diabetes. In enhancement, incorporating ragi to the diet plan program has actually been mentioned to put off the start of cataractogenesis, which is a problem of diabetes.

Also, take ideas from our previous blog on: How to Differentiate Between Healthy and Unhealthy Foods?

[imrmarketresearch20]

Fenugreek Seed Extract Market

The Global Fenugreek Seed Extract Market was valued at USD 7.05 million in 2021 and is expected to reach USD 17 million by the year 2028, at a CAGR of 13.4%.

 Fenugreek Seed Extract is a derivative obtained from a series of processing of fenugreek seeds. Fenugreek seed extract and oil are known to possess antioxidant, antidiabetic, antimicrobial, and antitumorigenic properties. Fenugreek Seed Extract is used as a thickening agent and an emulsifier. It is also used as a spice and flavoring agent in food preparation. Fenugreek is gaining importance both in food and medicines.

IMR offers a comprehensive overview of the market through the analysis of key parameters such as revenue, price, competition, and promotions, as well as the study, synthesis, and summarization of data from different sources. It analyzes the leading industry drivers and shows numerous market components. The information offered is thorough, dependable, and the result of a comprehensive primary and secondary study. IMR market research reports offer a comprehensive global market as well as an in-depth strategic sourcing methodology and analysis based on qualitative and quantitative research to anticipate market growth.

[marketdevelopment]

Fenugreek Seed Extract Market

Fenugreek Seed Extract Market size is projected to reach USD 13.05 Million units by 2027 from an estimated USD 5.48 Million units in 2019, growing at a CAGR of 13.4% globally.

Fenugreek Seed Extract is a derivative obtained from a series of processing of fenugreek seeds. Fenugreek seed extract and oil are known to possess antioxidant, antidiabetic, antimicrobial, and antitumorigenic properties. Fenugreek Seed Extract is used as a thickening agent and an emulsifier. It is also used as a spice and flavoring agent in food preparation. Fenugreek is gaining importance both in food and medicines.

IMR offers a comprehensive overview of the market through the analysis of key parameters such as revenue, price, competition, and promotions, as well as the study, synthesis, and summarization of data from different sources. It analyzes the leading industry drivers and shows numerous market components. The information offered is thorough, dependable, and the result of a comprehensive primary and secondary study. IMR market research reports offer a comprehensive global market as well as an in-depth strategic sourcing methodology and analysis based on qualitative and quantitative research to anticipate market growth.

[pujarathod]

What Are the Health Benefits of Fenugreek Seed Extract?

Fenugreek Seed Extract Market size is projected to reach USD 13.05 Million units by 2027 from an estimated USD 5.48 Million units in 2019, growing at a CAGR of 13.4% globally.

Fenugreek Seed Extract is a derivative obtained from a series of processing of fenugreek seeds. Fenugreek seed extract and oil are known to possess antioxidant, antidiabetic, antimicrobial, and antitumorigenic properties. Fenugreek Seed Extract is used as a thickening agent and an emulsifier. It is also used as a spice and flavoring agent in food preparation. Fenugreek is gaining importance both in food and medicines.

IMR offers a comprehensive overview of the market through the analysis of key parameters such as revenue, price, competition, and promotions, as well as the study, synthesis, and summarization of data from different sources. It analyzes the leading industry drivers and shows numerous market components. The information offered is thorough, dependable, and the result of a comprehensive primary and secondary study. IMR market research reports offer a comprehensive global market as well as an in-depth strategic sourcing methodology and analysis based on qualitative and quantitative research to anticipate market growth.

Download a Free Sample Copy of the Market Report:- 

https://www.introspectivemarketresearch.com/request/15780

The Major Players In The Fenugreek Seed Extract Market Include:

Alfrebro, Arjuna Natural Extracts, Naturalin Bio-Resources Co.Ltd, Shank’s extracts, Bio-Botanica, Nutra Green Biotechnology, Ambe Phytoextracts, Shaanxi Jory herb Biotechnology Co. Ltd., Xi’an Lyphar Biotech Co. Ltd., Garlic Industries Ltd., P.C. Kannan &Co., Amazon Spices Pvt Ltd., Avikara Foodstuff Trading LLC., Xi’an Mekeem Cosmetics Ltd., Indus Biotech, Nutra Green Biotechnology, Ambe Phytoextracts, Unique Organics, Hunan Nature Biotechnology

Fenugreek Seed Extract Market report covers a detailed analysis of current and upcoming market trends, company market shares, market projections, competitive benchmarking, competition mapping, and in-depth research of the most significant sustainability strategies and their impact on industry growth and competition. The research was conducted using a combination of primary and secondary data, as well as input from leading industry players.

Market has segmented the global Fenugreek Seed Extract market on the basis of type, application, and region:

The Fenugreek Seed Extract market is segmented by type and application. Growth between segments over the period 2022-2028 provides accurate calculations and forecasts of revenue by type and application in terms of volume and value. This analysis can help you expand your business by targeting eligible niches.

By Type:

 Powder, Liquid

 By Application:

 Food and Beverages, Pharmaceuticals, Cosmetics and Personal Care, Others

 By Regional Outlook (Revenue, USD Billion, 2017 – 2028)

North America (U.S., Canada,     Mexico)

Europe (Germany, U.K., France,     Italy, Russia, Spain, Rest of Europe)

Asia-Pacific (China, India,     Japan, Southeast Asia, Rest of APAC)

Middle East & Africa (GCC     Countries, South Africa, Rest of MEA)

South America (Brazil,     Argentina, Rest of South America)

Get a Discount on This Report @: 

https://www.introspectivemarketresearch.com/discount/15780

Covid-19 Impact and Recovery Analysis on Industry:

The COVID-19 pandemic has had devastating effects on several industry verticals globally. To constrain the number of cases and slow the coronavirus spread, various public health guidelines were implemented in different countries across the globe. COVID-19 protocols range from declaring national emergency states, enforcing stay-at-home orders, closing nonessential business operations and schools, banning public gatherings, imposing curfews, distributing digital passes, and allowing police to restrict citizen movements within a country, as well as closing international borders. With the growing vaccination rate, governments are uplifting the protocols to give a boost to the stagnant economy. Like other industries, Fenugreek Seed Extract Market has experienced a slowdown the growth, however, the market is expected to bounce back as restrictions are being lifted up by governments across the globe. 

Key Data Points Covered in the Report

Some of the critical data points covered in Fenugreek Seed Extract report include:

An     overview of the fenugreek seed extract market, including background and     evolution.

Macroeconomic     factors affecting the fenugreek seed extract market and its potential.

Fenugreek     seed extract market dynamics, such as drivers, challenges, and trends.

Detailed     value chain analysis of the fenugreek seed extract market.

The     cost structure of the products and segments covered in the study.

In-depth     pricing analysis, by key product segments, regions, and by major market     participants.

Analysis     of supply and demand, such as top producing and consuming geographies, imports/exports,     and overall trade scenario.

Analysis     of the Fenugreek Seed Extract market structure, including a tier-wise     categorization of key market participants.

Competitive     landscape of the fenugreek seed extract market, including detailed     profiles of the top players in this market.

If You Have Any Query of Fenugreek Seed Extract Market Report, Visit.@

https://www.introspectivemarketresearch.com/inquiry/15780

[industryrecentdevelopment]

Fenugreek Seed Extract Market: Global Industry Trend Analysis

Fenugreek Seed Extract Market size is projected to reach USD 13.05 Million units by 2027 from an estimated USD 5.48 Million units in 2019, growing at a CAGR of 13.4% globally.

Fenugreek Seed Extract is a derivative obtained from a series of processing of fenugreek seeds. Fenugreek seed extract and oil are known to possess antioxidant, antidiabetic, antimicrobial, and antitumorigenic properties. Fenugreek Seed Extract is used as a thickening agent and an emulsifier. It is also used as a spice and flavoring agent in food preparation. Fenugreek is gaining importance both in food and medicines.

IMR offers a comprehensive overview of the market through the analysis of key parameters such as revenue, price, competition, and promotions, as well as the study, synthesis, and summarization of data from different sources. It analyzes the leading industry drivers and shows numerous market components. The information offered is thorough, dependable, and the result of a comprehensive primary and secondary study. IMR market research reports offer a comprehensive global market as well as an in-depth strategic sourcing methodology and analysis based on qualitative and quantitative research to anticipate market growth..

The Major Players In The Fenugreek Seed Extract Market Include:

Alfrebro, Arjuna Natural Extracts, Naturalin Bio-Resources Co.Ltd, Shank’s extracts, Bio-Botanica, Nutra Green Biotechnology, Ambe Phytoextracts, Shaanxi Jory herb Biotechnology Co. Ltd., Xi’an Lyphar Biotech Co. Ltd., Garlic Industries Ltd., P.C. Kannan &Co., Amazon Spices Pvt Ltd., Avikara Foodstuff Trading LLC., Xi’an Mekeem Cosmetics Ltd., Indus Biotech, Nutra Green Biotechnology, Ambe Phytoextracts, Unique Organics, Hunan Nature Biotechnology

Fenugreek Seed Extract Market report covers a detailed analysis of current and upcoming market trends, company market shares, market projections, competitive benchmarking, competition mapping, and in-depth research of the most significant sustainability strategies and their impact on industry growth and competition. The research was conducted using a combination of primary and secondary data, as well as input from leading industry players.

Market has segmented the global Fenugreek Seed Extract market on the basis of type, application, and region:

The Fenugreek Seed Extract market is segmented by type and application. Growth between segments over the period 2022-2028 provides accurate calculations and forecasts of revenue by type and application in terms of volume and value. This analysis can help you expand your business by targeting eligible niches.

By Type:

Powder, Liquid

By Application:

Food and Beverages, Pharmaceuticals, Cosmetics and Personal Care, Others

By Regional Outlook (Revenue, USD Billion, 2017 – 2028)

North America (U.S., Canada, Mexico)

Europe (Germany, U.K., France, Italy, Russia, Spain, Rest of Europe)

Asia-Pacific (China, India, Japan, Southeast Asia, Rest of APAC)

Middle East & Africa (GCC Countries, South Africa, Rest of MEA)

South America (Brazil, Argentina, Rest of South America)

Covid-19 Impact and Recovery Analysis on Industry:

The COVID-19 pandemic has had devastating effects on several industry verticals globally. To constrain the number of cases and slow the coronavirus spread, various public health guidelines were implemented in different countries across the globe. COVID-19 protocols range from declaring national emergency states, enforcing stay-at-home orders, closing nonessential business operations and schools, banning public gatherings, imposing curfews, distributing digital passes, and allowing police to restrict citizen movements within a country, as well as closing international borders. With the growing vaccination rate, governments are uplifting the protocols to give a boost to the stagnant economy. Like other industries, Fenugreek Seed Extract Market has experienced a slowdown the growth, however, the market is expected to bounce back as restrictions are being lifted up by governments across the globe.

Key Data Points Covered in the Report

Some of the critical data points covered in Fenugreek Seed Extract report include:

An overview of the fenugreek seed extract market, including background and evolution.

Macroeconomic factors affecting the fenugreek seed extract market and its potential.

Fenugreek seed extract market dynamics, such as drivers, challenges, and trends.

Detailed value chain analysis of the fenugreek seed extract market.

The cost structure of the products and segments covered in the study.

In-depth pricing analysis, by key product segments, regions, and by major market participants.

Analysis of supply and demand, such as top producing and consuming geographies, imports/exports, and overall trade scenario.

Analysis of the Fenugreek Seed Extract market structure, including a tier-wise categorization of key market participants.

Competitive landscape of the fenugreek seed extract market, including detailed profiles of the top players in this market.

[rebeccamartinezpdx]

ROSEMARY 9 MENTAL & HEALTH BENEFITS: Growing & Gardening Herbs

ROSEMARY 9 MENTAL & HEALTH BENEFITS: Growing & Gardening Herbs

Rosemary Plant Health & Mental Benefits Medicinal Herbs Home Apothecary. Rosemary is Full of Antimicrobial, Anti-fungal, Anti-Viral, Antioxidant, Anti-inflammatory, Anti-apoptotic, Antitumorigenic, Antinociceptive and Neuroprotective Properties and Compounds The Scientific Name for Rosemary is Rosmarinus Officinalis which means “dew of the sea.” This is believed to come from myths of Aphrodite…

[wholehealthclinic]

~ ~~~ Spices play a significant part in the way food tastes, they are  also used in preserving foods. ~~~ Evey spice has its own individual properties. They are extremely taste enhancing, rich in flavour, bright in colour, as well as being  medicinal and therapeutic, with many advantages. ~~~ Spices have sufficient amount of evidence that they possess: ▪Anti-inflammatory ▪Antibacterial ▪Antimicrobial ▪Antifungal ▪Anti-tumorigenic ▪Anti-carcinogenic and antioxidant compounds. ~~~ Studies show that they contain a diverse range of bioactive constituents, including: ¤ Sulfur-containing ¤ Compounds ¤ Alkaloids ¤ Phenolic diterpenes ¤ Flavonoids and polyphenols, not forgetting vitamins and minerals. ~~~ Frequently consuming spices enhance your health,  however to achieve maximum health benefits you would need to combine certain combinations of some spices in order to be absorbed by the body, as they all act different and are effective. ~~~ Some spices increase the hydrochloric secretion of the stomach which produces blood flow and mucus lining. ~~~ They are a phenomenal contribution to health and wellness that go beyond seasoning foods. . . . . #spices #moroccanspices #freshspices #healthyspices #healingspices #naturalspices #africanspices #spiceshop #spicesouk #justspices #indianspices #herbsandspices #spicesandherbs #organicspices #healthtips #tastyfoods #foodtasting #enhancing #medicinal #therapeutic #antiinflammatory #antibacterial #antimicrobial #antifungal #antitumorigenic #anticarcinogenic #antioxidants #alkaloids #flavonoids #polyphenols (at London, United Kingdom) https://www.instagram.com/p/B5ApJORpZLR/?igshid=4ghxvogevzjl

[juniperpublishersjcmah]

Pterocarpus marsupium and Gymnema Sylvestre Powder in Alleviation of Biochemical Abnormalities Associated with Human Type 2 Diabetes Mellitus- Juniper Publishers

Abstract

Objectives: This observational study investigated the antihyperglycemic, antihyperlipidemic and antioxidant potential of Pterocarpus marsupium (Vijaysaar) and Gymnema sylvestre (Gudmar) (“VG”) Therapy in patients with type 2 diabetes mellitus.

Methods: Subjects with type 2 diabetes mellitus were administered a phytochemical formulation consisting 50 ml of aqueous extract derived from 3 gm “VG” powder was administered twice a day for six months. The blood glucose levels were monitored at monthly intervals; glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney functions were monitored at three monthly intervals.

Results: Daily administration of the “VG” Therapy regularly for 6 months resulted in significant reduction of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high-density lipoprotein cholesterol levels with concomitant decrease in total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein levels. Significant improvement in the biochemical markers of oxidative stress was recorded.

Conclusion: TThe results suggest that herbal formulation “VG” is beneficial in improving glucose and lipid homeostasis in type 2 diabetics and may serve as an adjunct therapy.

Keywords: Hyperglycemia; Dyslipidemia; Oxidative stress; Type 2 diabetes mellitus; Pterocarpus marsupiu; Gymnema Sylvestre

Abbrevations: BMI: Body Mass Index; DBP: Diastolic Blood Pressure; FPG: Fasting Plasma Glucose; GSH: Reduced Glutathione; HbA1c: Glycosylated Haemoglobin; HDL: High-Density Lipoprotein Cholesterol; LDL: Low-Density Lipoprotein Cholesterol; PPG: Postprandial Glucose; SBP: Systolic Blood Pressure; SOD: Superoxide Dismutase; SGOT: Serum Glutamate Oxaloacetate Transaminase; SGPT: Serum Glutamate Pyruvate Transaminase; TBARS: Thiobarbituric Acid Reacting Substances; VLDL: Very low-density lipoprotein cholesterol; VG: Vijaysaar and Gurmar

Introduction

Type 2 diabetes mellitus is reaching epidemic proportions worldwide and is a complex metabolic disorder characterized by hyperglycemia and dysregulated lipid metabolism [1,2]. Abdominal obesity and dyslipidemia (increased triglycerides, high LDL-cholesterol and low HDL-cholesterol), and hypertension, as well as altered platelet function [3] are the major risk factors contributing to type 2 diabetes. The metabolic defects that underlie the development of type 2 diabetes may include islet β-cells dysfunction, hyperglucagonemia, elevated endogenous glucose production, development of peripheral insulin resistance, inflammation of adipose tissue, and dysregulation of adipokines production [4]. Chronic elevation of blood glucose which is a central factor in the production of reactive oxygen species (ROS) [5] which in turn promote cellular damage and contribute to the development and progression of diabetic complications, such as cardiovascular disease, nephropathy, retinal blindness, neuropathy, and peripheral gangrene [6]. The conventional allopathic drugs, sulfonylureas, meglitinides, biguanides, metformin, thiazolidinediones, miglitol, acarbose, etc. although effective [7], are associated with minor or major side effects on long term use [8]. Statins used in the treatment of dyslipidemia have their own limitations [9].

Plant based Indian traditional medicines such as Ayurveda have been used since ancient times in the treatment of diabetes [10]. Ethnobotanical studies of traditional herbal medicine used for diabetes have identified more than 1,200 species of plants with hypoglycemic activity [10]. Medicinal plants are frequently considered to be less toxic and free from side effects than synthetic ones. The antidiabetic effects of several plant extracts and herbal formulations and their bioactive compounds have been identified and characterized for the treatment of diabetes mellitus [11,12].

Polyherbal formulations [13], have been shown to exhibit antidiabetic, antihyperlipidemic and antioxidant potential in animal models as well as in diabetic patients [14]. The phytochemical based formulations consisting of multiple herbs are liable to produce a large number of metabolites that may act on multiple targets in the body and hence, polyherbal formulations (Which are used in traditional practice) are preferred over mono therapeutic ones. Although, phytochemical based formulations have extensively been used, studies on their proof of efficacy are limited [15].

Gymnema sylvestre (Gudmar) is a climber grown in tropical forests of South-East and belongs to the family Asclepiadaceae G. sylvestre is considered to have a great anti-diabetic potential and used in several anti-diabetic formulations. There are several reports in animal models as well as in diabetic patients which shows that extract of G. sylvestre leaves have anti-diabetic potential [16,17], and these effects are attributes due to increase in insulin secretion [18]. Pterocarpus marsupium (Vijaysaar) is the most versatile plant with a wide spectrum of biological activities and belongs to the family Fabaceae. The P. marsupium is reported to be anti-diabetic and associated with anti-obesity, anti-hyperlipidemic, antiinflammatory, anti-oxidative, antitumorigenic functions [19-21]. The aim of this study is to explore the therapeutic potential of combined effects of the regular consumption of Pterocarpus marsupium and Gymnema sylvestre in human subjects with type 2 diabetes mellitus.

Materials and Methods

Study sample

A total of 45 type 2 diabetic patients attending the weekend diabetes clinic run by the Centre for Translational Research, School of Studies in Biochemistry, Jiwaji University, India expressed their willingness to participate in the study. Of these, 35subjects met the inclusion criteria who were then explained the necessity of maintaining defined lifestyle pattern during the course of the study. Out of 35 subjects, 8 subjects were eliminated during the course of the study due to non-compliance. The remaining 27 subjects took the drug regimen regularly as per the experimental design. Figure 1 shows the number of subjects enrolled and drop outs during the course of study. The patients’ baseline characteristics are summarized in (Table 1).

Data are expressed as Mean ± SEM;

BMI-Body mass index; SBP- Systolic blood pressure; DBP- Diastolic blood pressure; FBG-Fasting blood glucose; PPBG-Post prandial blood glucose; HbA1c: Glycosylated Haemoglobin.

Study design

The study design included following steps:

a) Selection of patients meeting inclusion criteria and those consented to participate in the study.

b) Measurement of anthropometric and biochemical parameters once before and at selected intervals during the course of the study.

c) Administration of “VG” Therapy in defined dose daily for a period of 6 months.

d) Measurement of parameters at the end of the study.

e) Analysis of the data.

Inclusion criteria

a) Non-insulin dependent diabetes diagnosed, as per the criteria of the World Health Organization;

b) Both genders between the ages of 30-65 years;

c) Body Mass Index in the range of 18.5 to 40;

d) Participants who understood the benefits of the study and signed a written informed consent;

Exclusion criteria

a) Presently using other blood glucose regulating agents;

b) Daily intake of alcoholic beverages;

c) Smokers consuming more than 1 pack/day;

d) Patients diagnosed as type I and insulin dependent type II diabetics;

e) Patients with hepatic or renal disease, pancreatitis, cardiac problems, uncontrolled hypertension, malnutrition and severe immune deficiency.

f) Non-compliance during the course of study.

Before starting the study all participating subjects were given a verbal explanation about the objectives of the study, nature of drug formulation (Kwath) to be consumed daily, (“VG” Therapy) rationale and duration of therapy in local language. They were asked to avoid a carbohydrate rich diet and advised regular walking for about 4-5 km during the course of study. The patients who consented to participate in the study were registered, anthropometric measurements; weight, height and waist were recorded at the beginning and at selected intervals during the study period. The patients were kept exclusively on “VG” therapy.

Composition of drug (VG) formulation

The “VG” formulation consisted of a mixture of Pterocarpus marsupium (Vijaysaar), and Gymnema sylvestre (Gurmar) (Table 2) and was provided by the M/S Dindayal Industries Ltd. India. The individual plants were identified by Prof. A.K. Jain, School of Studies Botany, Institute of Ethnobiology Jiwaji University Gwalior. Voucher specimens were prepared and deposited at the Centre (IOE-501 and IOE-505).

Composition of VG formulation: 1:1.

Preparation of VG kwath

3 gm of VG powder was suspended in 100 ml drinking water, kept overnight, boiled till 50% water is evaporated, cooled to room temperature and consumed on an empty stomach twice a day for six months under the supervision of an Ayurvedic Physician.

Biochemical parameters

The fasting and postprandial plasma glucose levels were monitored at monthly intervals, while the glycosylated hemoglobin (HbA1c), biomarkers of oxidative stress viz., Superoxide dismutase (SOD), catalase, reduced glutathione (GSH), Thiobarbituric Acid Reactive Substances (TBARS) and lipid profile, biochemical markers of kidney and liver functions were monitored at baseline, at the middle (3 month) and at the end (6 month) of the therapy.

Fasting and postprandial plasma glucose was estimated by the Glucose oxidase/Peroxidase method [22]. Glycosylated hemoglobin (HbA1c) was estimated by the ion exchange resin method [23]. Estimation of plasma total cholesterol by the Cholesterol oxidase Phenolaminophenazone CHOD-PAP method [24], triglyceride by GPO-PAP method [25], High density lipoprotein cholesterol (HDL) by Polyethylene glycol/CHOD-PAP method [26], Low-density lipoprotein cholesterol (LDL) and Very-low density lipoprotein cholesterol (VLDL) were calculated by the Friedewald formula, urea by the modified Berthelot method [27], uric acid by uricase/PAP method [28], creatinine by modified Jaffe’s kinetic method [29], Alanine transaminase (SGPT or ALT) and serum Aspertate transaminase (SGOT or AST) by the modified International Federation of Clinical Chemistry method [30], and bilirubin by method of L. Jendrassik [31] was assayed using standard kits from Crest Biosystems, Goa (India). Markers of oxidative stress such as super oxide dismutase (SOD) Winterbourn et al. [32], catalase by Sinha, [33], glutathione (GSH) Ellman et al. [34], and Thiobarbituric Acid Reactive Substances (TBARS) Ohkawa et al. [35] were checked.

Ethical clearance

The study protocol was duly approved by the Institutional Human Ethics Committee (JU/IHEC/2013-A/13).

Statistical analysis

Statistical analysis was carried out using a paired t test (Sigma stat 3.5). A p-value *p<0.05, **p<0.001 was considered statistically significant.

Results

Effect of VG therapy on hyper-glycemia

Table 3 shows the fasting and postprandial blood glucose levels at monthly intervals in subjects on “VG” therapy. A significant decrease was recorded for fasting (13.5% P<0.05), postprandial (15.0%, <0.001) glucose levels and glycosylated hemoglobin (9.8%) at the end of six months therapy.

Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values

HDL-High-density lipoprotein cholesterol; LDL-Low-density lipoprotein cholesterol; VLDL- Very- low density lipoprotein cholesterol; TC-Total cholesterol

Effect of VG therapy on lipidemia

Table 4 shows the results of the lipid profile of patients on “VG” therapy. Total cholesterol, triglycerides, LDL and VLDL were significantly decreased after six months therapy by 9.6%, 14.4%, 15.7%, and 14.4% respectively (P<0.05). HDL cholesterol was elevated from32.50±1.11 to 35.69 ± 1.02 (P<0.001).

Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values

HDL-High-density lipoprotein cholesterol; LDL-Low-density lipoprotein cholesterol; VLDL- Very- low density lipoprotein cholesterol; TC-Total cholesterol

Effect of VG therapy on biomarkers of oxidative stress

Significant (P<0.05, P<0.001), improvements in GSH level (from 1.98±0.17 to 2.59±0.21 mg/dl), SOD activity (from 0.63±0.05 to 0.94±0.08 μM/min/mg protein), catalase activity (from 7.64±0.24 to 9.44±0.23 μM/min/mg protein) were recorded. A significant decrease (P<0.001) in TBARS (from 457.19±8.09 to 415.15±7.47 (moles of Malondialdehyde/ml of blood) were recorded at the end of six months therapy.

Effect of VG therapy on markers of toxicity

The effect of “VG” therapy on kidney function was monitored by estimating urea, uric acid and creatinine levels in plasma at specified intervals during the course of therapy. The data presented in Table 5 showed significant (P<0.05), reductions in Urea (from 29.97±1.20 to 27.10±0.88mg/dl) and uric acid (from 5.08±0.20 to 4.67±0.20 mg/dl) and notable reduction in creatinine (from 0.78±0.06 to 0.73±0.05) at the end of six months therapy.

Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values

GSH: Reduced glutathione; SOD-Superoxide dismutase; TBARS- Thiobarbituric acid reacting substances.

Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values.

SGOT- Serum Glutamate Oxaloacetate Transaminase; SGPT- Serum Glutamate Pyruvate Transaminase.

Significant (P< 0.05), variations in biochemical markers of liver functions, namely bilirubin (from 0.83±0.06 to 0.70±0.04 mg/ml) and SGOT (from 22.47±1.61 to 18.00±1.04 IU/L) as well as SGPT (from 23.60±2.32 to 19.26±1.38 IU/L), at the end of six months was observed (Table 6).

Effect of VG therapy on hypertension and body mass index

Table 7 shows variations in systolic blood pressure (from 133.70±2.59 to 129.22±2.39 mmHg), diastolic blood pressure (from 81.70±0.97 to 79.56±0.93 mmHg) and body mass index (from 25.21±0.64 to 24.22±0.60 kg/m2) at the end of the six months therapy.

Discussion

Currently, plant based therapies (main or supplementary) are being used globally for the management of type 2 diabetes. In India, the indigenous systems of medicine viz., Ayurveda, Siddha & Unani employ plant based extracts for treatment of diabetes (Premeha in Ayurveda). Most of the Ayurveda based formulations depend on plants/herbs based decoctions, and powders. In the present study, administration of the aqueous extract of VG that consisted of equal amounts of the ingredients for over a period of 6 months to type 2 diabetic subjects resulted in significant improvements of altered biochemical markers. Significant alleviation in glucose homeostasis, as marked by noticeable changes in glycosylated hemoglobin, blood glucose levels, and lipid profile were observed. The G. sylvestre leaf extracts are reported to reduce hyperglycaemia in experimental animals [16], and human type II diabetics [17]. The G. sylvestre is reported to promote insulin secretion, probably by regeneration of pancreatic beta cells [17,18]. The gymnemagenin and gymnemic acids in G. sylvestre, showed to exhibit potent antioxidant, and hepatoprotective activities [36]. Ethanolic extract of G. sylvestre was reported to possess anti‑apoptotic potential in STZ‑induced diabetic cardiomyopathy, and affected the levels of leptin, insulin, dyslipidemia, apolipoproteins, lipids, LDH (serum lactate dehydrogenase) in experimental models [37]. Administration of deacylgymnemic acid DAGA (200mg/kg), a derivative of gymnemic acid reduced Systolic blood pressure and significantly improved the fasting plasma glucose and HOMA-IR (homeostatis model assessment insulin resistance) with marginal improvement in lipid profile [38]. The G. sylvestre is also reported to inhibit absorption of glucose from intestine. The atomic arrangement of gymnemic acid molecules is similar to that of glucose molecules and they reduce the blood glucose level by preventing the absorption of sugar molecule in the intestine. It is attributed by filling the receptor location in the absorptive external layer of the intestine by gymnemic acid molecules [39].

In a controlled study, an aqueous extract of the leaves of G. sylvestre, (GS4) when administered at the dose of 400mg/day, to subjects with insulin-dependent diabetes mellitus (IDDM), the insulin requirement came down together with fasting blood glucose, HbA1c and serum lipid levels soon after therapy. However, the GS4 administration failed to check glycosylated haemoglobin and glycosylated plasma protein levels on long term follow up. The GS4 therapy is reported to enhance insulin secretion rate, either by regeneration or revitalisation of the beta cells [40].

The effectiveness of GS4, further investigated as a supplementary drug to conventional oral anti-hyperglycemic drugs. Administration of GS4 (400mg/day) to 22 Type 2 diabetic patients receiving conventional therapy resulted in significant reductions in blood glucose and, glycosylated hemoglobin level. In addition, five of the 22 diabetic patients showed improved glycemic control with GS4 alone and were discontinue their conventional drug [17].

In another study, supplementation of the diet with G. sylvestre at the dose of 500 mg per day for a period of 3 months reduced polyphagia, fatigue, blood glucose levels with concurrent reductions in HbA1c, lipid profile suggesting beneficial effect of G. sylvestre supplementation in the management of diabetes mellitus [41].

Pterocarpus marsupium is traditionally used in Indian ayurvedic medicine for the treatment of diabetes and has been shown to control diabetes in experimental animals [42]. The phenolic C-glycosides present in P. marsupium regulated glucose homeostasis and significantly decreased the TNF-α level in experimental diabetes [43]. The phenolics, marsupsin, pterosupin, pterostilbene and (-)-epicatechin present in P. marsupium have been identified as the blood sugar lowering components [20,44].

The alcohol extract of the bark of P. marsupium Roxb shown to exhibit potent antidiabetic activity and corrected the metabolic alterations in diabetic rats [42]. Aqueous extracts of P. marsupium Linn significantly attenuated hyper insulinaemia as well as hypertriglyceridaemia and also prevented the alteration in metabolic patterns [45]. The Indian Council of Medical Research undertook an anti-diabetic phase II open trial at four centers across Indian using Vijaysar (Pterocarpus marsupium). Vijaysar was tested in newly-diagnosed or untreated non-insulin dependent diabetes mellitus (NIDDM) patients between 35 and 60 age for 12 weeks. Among the 93 patients who completed 12 wk of treatment, both the fasting and postprandial blood glucose levels fell significantly (P < 0.001), by 32 and 45mg/dl at 12 wk from the initial means of 151 and 216mg/dl respectively. Mean HbA1c Other laboratory parameters remained stable during the designated treatment period of 12 wk. Also, no side-effects were reported [46].

Our previous study done with the polyherbal formulation, “GSPF kwath” which contains Vijaysar and Gurmar as two of the ingredients has shown antidiabetic and antioxidative effects [13]. “GSPF kwath”, showed 23.5%, 26.7% and 11.7% reductions in fasting, postprandial blood glucose and HbA1c respectively. In the present study “VG” containing only two of the components of GSPF proved highly beneficial in restoring not only hyperglycemia but also lipidemia and antioxidative potential. The changes observed on glycemic, lipidemic and oxidative stress. Oral administration of “VG” therapy for 6 months had no adverse effects, either on kidney or liver functions and in fact showed a significant improvement in the functioning of these vital organs.

Conclusion

In conclusion, the “VG” administration to type 2 diabetic patients with varying degrees of glycemia, lipidemia and oxidative stress provide an efficient alternative to conventional antidiabetic drugs when coupled with active lifestyle and dietary changes. Significant decrease in biochemical markers viz., blood glucose, HbA1c, total cholesterol, triglycerides, LDL-cholesterol, and VLDL-cholesterol and higher values of HDL, following VG therapy are testimony to the anti-diabetic efficacy of VG. Further, the formulation did not show any adverse effects on liver and kidney functions and may be a potential natural and safe therapy for treatment and prevention of diabetic complications but randomized controlled trials are required to confirm these findings.

Acknowledgment

We thank M/S Dindayal Industries Ltd., Gwalior (M.P.) for the supply of the Vijaysaar and Gurmar powder and the financial support from AYUSH, New Delhi, (F.NO. Z.31014/02/2009/ EMR-CCARS) is duly acknowledged. We are grateful to all the human subjects who volunteered to participate in the study. Our profound thanks extend to colleagues of the laboratory and students for their unreserved support in conducting this study.

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[didanawisgi]

Ginger

Good for What Ails You

March 2011

By Robin Gettleman

Due to the powerful phenolic compounds found in ginger, this spice has been studied for its benefits for a wide range of ailments and health disorders. While often referred to as a root, ginger is in fact a spice that contains potent antioxidants such as shogaols, zingerone, and gingerols.1 These strong compounds have been linked to providing relief for dozens of issues, including cough, bronchitis, upper respiratory tract infections, migraine headaches, motion and morning sickness, rheumatoid arthritis, post-surgical pain, flatulence, loss of appetite, diarrhea, upset stomach, stomachache, colic, dyspepsia, and general and chemotherapy-induced nausea. It has even been used topically as an analgesic.1

Ginger has been used as a home remedy for thousands of years.

Ginger’s History

The health benefits of ginger have a history almost as old as civilization itself. Historians have found references to the use of ginger, known botanically as Zingiber officinale, in the writings of nearly every ancient society, including Chinese, Indian, and Roman. In fact, the ancient Roman Empire first started importing ginger nearly two thousand years ago.2 Due to its alluring smell, great taste, and medicinal properties, the spice became extraordinarily popular in Europe. This rise in demand, combined with the expensive cost of shipping the product from Asia, forced Europeans to find ways to make ginger less expensive and more readily available. They did this by introducing ginger to the West Indies, Mexico, and South America, and then exporting it back to Europe. Since ginger thrives in a tropical climate, it is produced in the United States in Hawaii, Florida, and California.1 Internationally, it is exported mainly from Jamaica, Fiji, India, China, and Australia.

Ginger’s Benefits

Motion Sickness

Many prescription or over-the-counter products on the market that are developed to combat motion sickness or nausea have side effects like drowsiness and dry mouth. Ginger has shown in several studies that it may provide significant relief to the above symptoms without the detrimental side effects.3

In one study comparing ginger to a placebo in an attempt to measure its ability to reduce symptoms associated with motion sickness, ginger was measured to be potentially more effective than placebo.3 This trial studied 80 beginner-level sailors who were prone to motion sickness. Half of the group took powdered ginger and the other half took placebo. The half who took ginger experienced a reduction in vomiting and cold sweats compared to placebo.

Morning Sickness

Ginger has been used as a home remedy for thousands of years, with one of the longest known uses as a treatment for morning sickness accompanying pregnancy. Researchers presented a study that finally put this folk remedy to the test. In a double-blind, randomized, placebo-controlled trial, a group of pregnant women ingested 125 mg of ginger extract four times a day for four days.4 All the women were less than 20 weeks pregnant, and the women who ingested the ginger showed significantly reduced symptoms of morning sickness, compared with women who consumed placebo.

Inflammation

Ginger contains ultra-potent anti-inflammatory compounds called gingerols, which are the substances that many scientists believe are responsible for the reduction in inflammation people experience when they start taking ginger supplements regularly. Case in point, a recent study involving patients who tried conventional drugs to alleviate painful symptoms found that 100% of patients with muscular discomfort experienced relief of pain or swelling when they consumed ginger on a daily basis.2

In a compelling study published in Osteoarthritis and Cartilage, 29 patients with debilitating arthritis in the knee participated in a placebo-controlled, double-blind, crossover study.5 The study had each patient start with placebo or ginger, and then switch after 3 months, writing down the results. At the end of the first half-year of the study, the patients who were taking ginger experienced significantly less pain than those on the placebo. Additionally, the patients using ginger reported improvements on a standardized scale used to assess mobility.

A separate study measuring the anti-inflammatory properties of red ginger in the Journal of Medicinal Food found positive results as well.6 In this study, Japanese researchers prepared a 40% ethanolic extract from dried red ginger and evaluated its anti-inflammatory activity. After confirming that antioxidant shogaols and gingerols suppressed production of inflammatory mediators, the researchers discovered that red ginger extract “has a potent suppressive effect on acute and chronic inflammation, and inhibition of macrophage activation seems to be involved in this anti-inflammatory effect.”6

Ginger Tips

Choose fresh ginger over dried ginger to preserve the high levels of gingerol content.

Fresh ginger root should be firm, smooth, and free of bruises and mold.

Fresh ginger can be stored in your refrigerator for up to three weeks if left unpeeled.

Dried ginger should be kept in a tightly sealed glass container in a dry, cool, and dark place.

The center of the ginger root is the most flavorful.

When shredding ginger, be sure to shred in the direction of the fibers.

Helps Reduce Chemotherapy-Induced Nausea

Chemotherapy-induced nausea is the type of stomach unease or discomfort that begins within 24 hours after the administration of chemotherapy. Many patients treated for cancer experience this awful side effect, which can lead to vomiting, dry heaving, and overall sickness. It is known that meals high in protein may offer some protection against the onset of nausea, and a study recently tested whether high-protein meals with added ginger had any beneficial effect.

A team at Siena College in Loudonville, New York, studied this hypothesis on 28 patients with cancer who were receiving chemotherapy for the first time.7 Control group patients ate their normal diets, while another group drank a high-protein shake with ginger twice daily. The results were striking.

Patients taking the high-protein shake with ginger reported significantly fewer instances of nausea, and electrical measurements of the stomach muscles revealed less gastric dysrhythmia, leading the researchers to conclude that high protein meals with ginger reduced the nausea that follows chemotherapy.7

Colon Cancer Prevention

In a study done by scientists at the University of Minnesota, gingerol exhibited anti-inflammatory and antitumorigenic effects.8 At first, scientists were unsure about why gingerol displayed such effectiveness against colon cancer, but the study revealed that the leukotriene A(4) hydrolase protein (LTA[4]H), whose activity can act as a catalyst for colon cancer cells, is targeted by gingerol.8

The researchers gave a group of specially bred mice an injection of gingerol three times a week before and after injecting human colorectal cancer cells into them. Tumors first appeared 15 days after mice were injected, but only 4 tumors were discovered in the gingerol group, as opposed to 13 in the control mice.

The findings revealed that “gingerol effectively suppressed tumor growth in mice by inhibition of LTA(4)H activity…these findings support the anticancer efficacy of gingerol for the prevention of colorectal cancer.”8

Fights Ovarian Cancer

While the effectiveness of ginger extracts against inflammation and tumors has been shown above, perhaps ginger has the most promising effect in the fight against ovarian cancer.

At the 97th Annual Meeting of the American Association for Cancer Research, Dr. Rebecca Liu and her team from the University of Michigan made a presentation about gingerol’s ability to kill ovarian cancer cells by inducing apoptosis (programmed cell death) and autophagocytosis (self-digestion).9

The presentation focused on Dr. Liu’s team’s experiments that examined the effects of a whole ginger extract containing 5% gingerol on several different ovarian cancer lines. While traditional chemotherapeutic agents suppress inflammation the same way ginger is purported to, the danger is that cancer cells may become resistant to the drugs. Dr. Liu believes that ginger may be unique in this respect because cancer cells show no sign of becoming resistant to its cancer-fighting properties. Her team’s data showing that exposure to ginger extract caused cell death in all ovarian cancer lines studied bolster this claim.9

References

1. Grotto D. 101 Foods That Could Save Your Life. New York: Bantam Bell; 2008.

2. Available at: www.whfoods.com/genpage.php?tname=foodspice&dbid=72. Accessed December 14, 2010.

3. Available at: www.umm.edu/altmed/articles/ginger-000246.htm. Accessed December 14, 2010.

4. Willetts KE, Ekangaki A, Eden JA. Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial. Aust N Z J Obstet Gynaecol. 2003 Apr;43(2):139-44.

5. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis and Cartilage. 2003 Nov;11(11):783-9.

6. Shimoda H, Shan SJ, Tanaka J, et al. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J Med Food. 2010 Feb;13(1):156-62.

7. Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med. 2008 Jun;14(5):545-51.

8. Jeong CH, Bode AM, Pugliese A, et al. [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res. 2009 Jul 1;69(13):5584-91.

9. Liu R. Presentation at the 97th Annual Meeting of the American Association for Cancer Research.

[healthtimetaylor]

Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation.

PMID:  J Cancer. 2019 ;10(23):5843-5851. Epub 2019 Oct 6. PMID: 31737120 Abstract Title:  Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation. Abstract:  The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric cancer when chemotherapy is needed. Unfortunately, resistance to chemotherapeutic agents is the most frequent occurrence during treatment, which indicates a need for the discovery of novel therapeutic anticancer drugs.The tumor-suppression effect of eight different cucurbitacins was evaluated in gastric cancer cell lines, and the Cucurbitacin E (CuE) showing the greatest effect was used in further studies to explore the mechanism and potential synergistic effect of Dox bothand.Compared with other cucurbitacins, CuE showed the greatest antiproliferative activity against the gastric cancer cell lines. Further investigations revealed that CuE suppressed the growth of gastric cancer cell lines through the induction of G2/M arrest and subsequent apoptosis by impairing AKt activation and reducing its expression in gastric cancer cells. Furthermore, our results indicate that CuE can significantly enhance the cytotoxicity of doxorubicin (Dox) bothand.In summary, we present the first evidence of the efficacy of CuE for the inhibition of gastric cancer growth and the synergistic antitumorigenic effect of CuE and Dox, bothand.

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[tumimmtxpapers]

Cancer Immunotherapy: Targeting Tumor-Associated Macrophages by Gene Silencing.

Related Articles Cancer Immunotherapy: Targeting Tumor-Associated Macrophages by Gene Silencing. Methods Mol Biol. 2020;2115:289-325 Authors: Zins K, Abraham D Abstract Tumor-associated macrophages (TAMs) are representing a major leukocyte population in solid tumors. Macrophages are very heterogeneous and plastic cells and can acquire distinct functional phenotypes ranging from antitumorigenic to immunosuppressive tumor-promoting M2-like TAMs, depending on the local tissue microenvironment (TME). TAMs express cytokines, chemokines, growth factors, and extracellular matrix (ECM) modifying factors, and the cross talk with the TME regulates pathways involved in the recruitment, polarization, and metabolism of TAMs during tumor progression. Due to their crucial role in tumor growth and metastasis, selective targeting of TAM for the treatment of cancer with therapeutic agents that promote phagocytosis or suppress survival, proliferation, trafficking, or polarization of TAMs may prove to be beneficial in cancer therapy. In this chapter, we will discuss TAM biology and current strategies for the targeting of TAMs using small interfering RNA (siRNA)-based drugs. In the past few years, advances in the field of nanomedicine pave the way for the development of siRNA-based drugs as an additional class of personalized cancer immuno-nanomedicines. Fundamental challenges associated with this group of therapeutics include the development process, delivery system, and clinical translation for siRNA-based drugs. PMID: 32006408 [PubMed - in process] http://dlvr.it/RPDdJf

[poop4u]

CBD Oil for Dogs

#poop4u #dogs

The post CBD Oil for Dogs by Elizabeth Anderson Lopez appeared first on Dogster. Copying over entire articles infringes on copyright laws. You may not be aware of it, but all of these articles were assigned, contracted and paid for, so they aren't considered public domain. However, we appreciate that you like the article and would love it if you continued sharing just the first paragraph of an article, then linking out to the rest of the piece on Dogster.com.

CBD dispensaries have popped up in many states all over the country in people’s hunt for wellness. But CBD oil can also be used to help dogs with anxiety and other issues. What is CBD and how does it work? And, will it give your dog the munchies? First, let’s define some of the terms that can be confusing.

“Cannabidiol, also known as CBD, is a cannabinoid �� a naturally occurring compound found in both hemp and cannabis (cannabis is also referred to as marijuana),” says Jodi Ziskin, director of communications with Treatibles in Petaluma, California.

Hemp and marijuana are “Both members of the Cannabis sativa plant and share similarities but have very distinct differences due to each plant’s biological structure,” says Jon Neveloff, partner with King Kanine in Fort Lauderdale, Florida. Consider that a rice cake and rice pudding are from the same plant but quite different.

“CBD is one of hundreds of compounds found in cannabis. It is the most prevalent compound in hemp, a special strain of cannabis that has only trace amounts of THC, the substance in medical and recreational strains of hemp that is associated with psychoactive effects,” says Joey DiFrancesco, CEO and founder of LolaHemp in New York City. This is crucial because THC can be toxic to pets. (For more THC specifics, see “Why the Farm Bill Matters” on page 38.) “CBD is non-psychoactive,” Joey adds. It won’t get your dog high in any way.

Hemp Oil vs CBD Oil

Both CBD oil and hemp oil come from the same plant, but CBD oil comes from the flowers, leaves and stalk of the hemp plant, while hemp oil comes from the seeds of industrialized hemp plant.

Hemp oil is a nutritional supplement full of nutrients that can be used in cooking and for moisturizing — like in soaps or lotions. It has a variety of other manufacturing uses, such as making plastic and as a bio-diesel fuel.

CBD oil is a supplement used for medicinal purposes, like treating various conditions, such as inflammation and anxiety, among others.

Help for anxiety

Many owners report benefits to using CBD oil for dogs, and CBD oil has been recommended to assist with many ailments that plague our furry friends, including anxiety.

“The most common conditions that relate to anxiety include location and separation anxiety, as well as noise phobias,” says Annie Chrysler, CBD specialist and product manager with SpaRoom based in Cleveland, Ohio. “For example, CBD oil can provide noticeable relief to dogs who demonstrate car ride anxiety or who experience anxiety when visiting the veterinarian’s office. CBD oil can also provide noticeable relief for dogs who have noise sensitivities such as fireworks and thunderstorms.”

Amanda Howland, co-founder and CTO of ElleVet Sciences in Portland, Maine, explains further. “Pain and anxiety are so interrelated in dogs that we wanted to have both a profound anti-anxiety effect and an extremely effective pain management effect, to help the pet feel better in every way.”

Angie Krause, DVM, with Boulder Holistic Vet in Boulder, Colorado, says in her experience CBD is consistently effective for treating dogs with mild to moderate anxiety. “For severe generalized anxiety, I have more success with drugs like Prozac,” she adds.

So how does it work? It’s based on science; the same science that explains how CBD works with man and man’s best friend, who have some biology in common. That’s because all mammals have an endocannabinoid system (ECS.)

CBD can help keep your dog calm around other animals. Photography by: ©chendongshan | Getty Images

Jillian Dutson, marketing and advertising manager with Pet Releaf, based in Littleton, Colorado, explains. “When your dog consumes CBD, his ECS is activated. The ECS works as a two-way communication system with various systems in the body such as the immune, nervous and digestive systems just to name a few. This two-way communication allows these parts of the body to speak to one another to help them function at optimal levels of health.”

And there’s more to it: “Although further studies are needed, initial findings show that CBD binds to a number of endocannabinoid receptors,” says Lauren Brychell, marketing coordinator with cbdMD in Charlotte, North Carolina. “These receptors regulate everything from inflammation to pain perception, and CBD has shown the ability to potentially raise dopamine levels and improve mood while reducing symptoms of anxiety.”

Speaking of studies, “Most of the research done on cannabidiol, indeed cannabis writ large, has taken place outside of veterinary research, which is not uncommon, as vet research typically lags behind human medicine,” Joey says.

More benefits and dosage

There are many common uses for CBD oil in dogs, other than anxiety. “I use CBD for dogs with seizures, arthritis, cancer, pain, chronic inflammation and allergies,” Dr. Krause says.

Joey, too, cites success in using CBD for the Big C. It can “Shrink tumors in several types of cancer both because it appears to have antitumorigenic properties of its own and because it appears to enhance the effectiveness of some chemotherapy agents.”

CBD oil has also been used to treat the following ailments:

Sleep issues

Vomiting and nausea

Muscle spasms

Glaucoma

Digestive issues and appetite loss

Skin conditions

As with any supplement or medication, getting the correct dose is crucial. Many of the manufacturers state dosing suggestions should be determined based on each dog’s individual stats and condition. Some suggest generic guidelines as a starting point: 1 mg per 10 pounds of body weight twice a day; Dr. Krause recommends 0.5 mg/kg of CBD twice daily for anxiety.

Of course, always get input from your dog’s vet on any treatment. “First, many symptoms that CBD may help with can be an indication of a deeper and more serious medical problem that needs to be treated,” Joey says. “Second, CBD oil can interfere with the metabolization of other drugs (in a similar way that grapefruit does). Third, the answer to dosing questions is dependent on what condition is being addressed.”

And don’t assume you and Fido are in for a quick fix. “While some dog owners may notice an immediate difference in their pet, we suggest waiting two to three weeks to see the full effects,” Lauren says.

Giving to your dog

Whatever the dosage, you have a couple of options on how to administer CBD oil: topically or ingested. But which is better?

“The answer ultimately depends on the individual dog,” Annie says. “More commonly, topical application can provide a more localized sense of relief, such as pain relief in the hips and legs. Ingesting can provide a broader sense relief, such as separation anxiety relief.”

Angela Ardolino, founder and CEO of CBD Dog Health in Tampa, Florida, lists other conditions that lend themselves to direct applications. “It has incredible benefits for skin issues, including allergies, hot spots, bug bites, skin tumors, warts and cysts when applied topically,” she says.

If you do decide to go the oral route you have more choices here, too. According to Angela, “The best way to administer CBD is to lift the dog’s lip and administer it right onto the gums (it is absorbed through capillaries in the gums).” Putting it under the tongue is also common. CBD oil can be mixed in with your dog’s food or treats made with CBD oil.

It may come down to what your dog — and wallet — prefer. “The oils and treats that I use in the practice have the same hemp extract in both,” Dr. Krause says. “The oil is more cost effective.”

Why the Farm Bill Matters

In December 2018, President Trump signed the much anticipated 2018 Farm Bill into law. Whether you’ve got a city dog or a country dog this is something that can affect dog owners everywhere regarding CBD. In short, the Farm Bill officially legalizes cultivating and producing industrial hemp and removing the crop from the federal list of controlled substances.

The Farm Bill helps lit restrictions off of CBD production. Photography by: ©CaraMaria | Getty Images

That last part may also free up your veterinarian to be able to discuss CBD oil more in depth with you. The Federal Drug Enforcement Administration named cannabis and cannabinoid products as Schedule I controlled substances, with no accepted medical use. That hindered veterinarians’ ability to administer or prescribe them. Some vets opted not to talk about CBD as a treatment because of these restrictions.

“Now that the Farm Bill has passed, I believe this will not be an issue moving forward,” says Angie Krause, DVM, with Boulder Holistic Vet in Boulder, Colorado. “Hemp is legal at a federal level, and each state will decide how they want to regulate hemp. If a state declares hemp illegal, it may limit the veterinarian’s ability to prescribe or discuss hemp/CBD.”

The Farm Bill will:

Define industrial hemp broadly to cover all parts of the Cannabis plant including seeds, derivatives, extracts, cannabinoids, etc. as long as it has a THC level of 0.3 percent or less.

Remove hemp completely from the Controlled Substances Act (CSA).

Make the USDA the sole federal regulatory agency overseeing hemp cultivation.

Authorize and fund hemp research as part of the Supplemental and Alternative Crops program and the Critical Agricultural Materials Act.

Regarding that research, Heidi Hill, Holistic Hound founder and trained homeopath in Berkeley, California, says, “We are thrilled with this victory … This decision will also fund and allow long-overdue research into the many health and wellness benefits of this amazing plant.”

A final look at terminology

Some manufacturers tout CBD isolate while others say full spectrum is better. Here’s the difference and an industry professional’s take on each:

Full spectrum, or whole plant, CBD contains all other cannabinoids found in the marijuana plant, including minute amounts of THC. “[Full spectrum] contains all the beneficial constituents of the whole plant, including other cannabinoids, terpenes, flavonoids and fatty acids. These naturally occurring components all work together for enhanced benefit and what is called ‘the entourage effect,’” says Heidi Hill, Holistic Hound founder and trained homeopath in Berkeley, California.

CBD isolate is purified CBD that has been extracted from the marijuana plant and isolated, hence the name, from the other cannabinoids. “Our knowledge about CBD and its benefits are well-established, but we are just beginning to learn about the possible benefits of other compounds in the hemp plant. To claim the benefit of a full spectrum product over CBD itself, is premature,” says Joshua Sosnow, DVM, chief medical officer of CompanionCBD and owner of Arizona practices North Scottsdale Animal Hospital and Desert View Animal Hospital.

Know the facts about CBD to keep your dog healthy and relaxed. Photography by: ©Getty Images

Sharing pros and cons

If you have other pets at home with similar conditions, they may also benefit from the same product your dog uses — with different dosages, of course. “There is a big difference in dosing for dogs and cats,” Amanda says. “Cats are not small dogs! The half-life in cats is extremely short, meaning they metabolize it very quickly. We have very specific dosing for dogs and for cats based on science.”

According to Colette Florido, founder and president of CR Pets Thrive in St. Petersburg, Florida, says, “A high-quality CBD product will work equally well for both cats and dogs. The main difference you’ll find between options for cats and dogs is what other flavors are combined with the CBD, knowing that each pet has their preferences.”

Some CBD products for cats come in catnip or fish flavors, while beef or peanut butter flavors are used for dogs.

The most important part about sharing CBD oil is to never share products made for humans with your dog or any other pets. “It is vital to make sure that the oil you are buying is not just a human product with a paw print on the label,” Angela says. “Human products may contain artificial flavoring, like xylitol, that is toxic to dogs.”

Joey gave a flavor-specific example of toxicity. “Wintergreen oil, which is perfectly fine for people and probably won’t bother a dog, is potentially toxic to cats. It is commonly found in CBD products made for people.”

There is much more research to be done on using CBD oil for your dog but hopefully you now know more about how it works and how it might help. And just to confirm: CBD oil won’t give your dog the munchies. If your dog is craving Scooby snacks, it has nothing to do with a supplement.

CBD QAFs

Nope, not FAQs, these are Questions to Ask Frequently when looking for quality CBD for your dog.

Make sure to ask the right questions to keep your dog safe! Photography by: ©vitalytitov | Getty Images

Jon Neveloff, partner with King Kanine in Fort Lauderdale, Florida, says, “The most important question is: Are there lab results on this bottle of CBD? If so, what are they testing for?”

“Know where the hemp is grown,” recommends Angie Krause, DVM, with Boulder Holistic Vet in Boulder, Colorado. “U.S. hemp grown organically is preferred. Extraction technique is very important. For cats, I prefer CO2 extraction. This ensures there are no harmful chemical residues. A guaranteed analysis should be available from the manufacturer to quantify the concentration of CBD in each ml.”

Colette Florido, founder and president of CR Pets Thrive in St. Petersburg, Florida, says to “ask to see the company’s certificate of analysis (COA) and lab tests. If the company can’t or won’t [share it], do not buy. It means they don’t test for pesticides, solvents, mold, yeast and E. coli. An ethical CBD company will proudly show you their COA.”

Jillian Dutson, marketing and advertising manager for Pet Releaf, in Littleton, Colorado, suggests you ask these questions when comparing CBD products:

Where is their hemp grown and can they prove it?

If claiming organic, do they have the necessary certifications to verify these claims?

How much CBD is in their products and do they have consistent third-party testings to confirm these amounts?

Jodi Ziskin, director of communications with Treatibles in Petaluma, California, adds these:

Does the milligram count on the label reflect the amount of hemp oil or does it include the carrier oil(s)?

Is the company a National Animal Supplement Council (NASC) member and are they fully compliant with their packaging and marketing?

“We bought and tested about 20 different products we got from pet stores and online, and out of the 20, none had what was advertised on the label and some had no CBD at all,” said Amanda Howland, co-founder and CTO of ElleVet Sciences in Portland, Maine. “Pet owners need to be careful and research the company.”

Thumbnail: ©Teran Buckner | Phido Photography

About the author:

Elizabeth Anderson Lopez is an award-winning writer based in Lake Forest, California. She and her husband have many pets, including two English Bull Terrier rescues named Dexter and Maybelene. You can contact her at fromconcepttocontent.com.

Learn more about dog health care at dogster.com:

Treating Separation Anxiety in Dogs

Dog Seizures: What Causes Them and How Should They be Treated?

7 Means of Dog Anxiety Treatment

The post CBD Oil for Dogs by Elizabeth Anderson Lopez appeared first on Dogster. Copying over entire articles infringes on copyright laws. You may not be aware of it, but all of these articles were assigned, contracted and paid for, so they aren't considered public domain. However, we appreciate that you like the article and would love it if you continued sharing just the first paragraph of an article, then linking out to the rest of the piece on Dogster.com.

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[ajoyfulvoidstudentlove]

Different cultures have emphasized on many health benefits of ginger since its inception. The use of ginger as a medicine has been seen for thousands of years, but only recently, science has been able to validate the wonderful health benefits of this superfood.

Images source: pixabay

Ginger is a wonderful tasting masala that is popular in Asian and Indian cuisine. It is mixed with sweets as well as tea and other beverages. Ginger has been revered in many cultures for its medicinal properties because it can help in removing nausea, digestive issues, and pain. Ginger is in the same family as cardamom and turmeric.

We all know and eat ginger during our lifetime. It is a sweet, aromatic root with tart and warm flavor. Some people enjoy drinking it as tea, some eat it with sushi, and some people enjoy it like candy. Ginger rhizome is a common food ingredient used in the treatment of a variety of conditions for thousands of years in ayurvedic and traditional Chinese medicine.

Ginger is usually used to treat conditions related to digestion: nausea, stomach, disorders, diarrhea, vomiting and motion sickness. To date, many people fill ginger with a gut if they get sick. Clinical studies have shown ginger helpful in nausea during pregnancy and it is one of the safest natural remedies for this type of condition.

Ginger contains nutrients which contain spasmolytic properties, which is a way of saying that ginger calms the micronutrients and relaxes the intestines. Doctors usually recommend ginger to those patients who have undergone intestinal surgery, because it offers very protection against infections. Ginger helps in many anti-inflammatory problems that occur in smooth or skeletal muscles.

The properties found in ginger are as follows:

• Immunomodulatory

• Antitumorigenic

• Anti-inflammatory

• Antiarthritic

• Antihyperglycemic 

• Antihyperlipidemic 

• Antiemetic actions 

People use ginger not only for GI troubles but also for arthritis, pain reduction, cold and flu relief, nausea, digestion, inflammation, headaches, and even various cancers. 

Ginger and its components are shown to prevent the following cancers:

• Stomach cancer

• Breast cancer

• Colon and rectal cancer

• Liver cancer

• Pancreatic cancer

• Leukemia

• Lung cancer

• Melanoma

• Pancreatic cancer

• Prostate cancer

• Skin cancer

Anticancer properties of ginger have been found to activate the molecular system, which causes cell apoptosis (cell suicide) in cancer cells so that pro-apoptosis genes can be activated. Increasing the genetic cancer inhibitors within ginger also regulates cancer-related genes and proteins.

How to use ginger for cancer treatment

According to research, gingerols is some of the most important bio-inflammatory components in ginger. Most people have taken ginger products, but they may experience limited benefits because the supplement contains plain ginger powder. So, use fresh raw ginger.

The root of fresh raw ginger is a key ingredient in Asian cuisine and is used in soup, rice, and noodle. Worldwide, it is also used to savor beverages such as tea, specialty coffee, cocktail, lemonade, and smoothies. Ginger cookies, gingerbread, and candied ginger are popular holiday favorites.

You can store fresh ginger in a tightly wrapped plastic bag in the refrigerator, and peel it and grind it before use. Add it to any suitable dish for extra flavor. you can use dried if fresh ginger is not available only.

In most dishes, one-eighth part of spoonful ginger can be replaced for one teaspoon of freshly grated ginger. Ginger can be found in the herbs and most grocery stores.

You can make your ginger tea by adding grated ginger in boiled water. It is a natural remedy for cough and colds and sore throat. Ginger juice and ginger chewing are other home remedies, often given to reduce nausea and digestive. It is often used in herbal products like shampoos, soaps, and massage oils.

Here, 

Some ways of using ginger in daily life

• Add fresh ginger to a smoothie

• Add fresh ginger to a juice

• Add ginger to a stir-fry 

• Add ginger to a homemade salad dressing

• You can make your ginger tea by adding fresh ginger in boiling water.

• Use to spice up any fish recipe

• Add ginger for an all-season cocktail

The properties of ginger cancer are clear and profound, which means that soon pharmaceutical companies will try to run a campaign against it. Do not come for this. Ginger can be just one of the most powerful natural cancer treatments.