#Valentina Stadler

[joaquimblog]

IRINA LUNGU I JEAN-FRANÇOIS BORRAS CANTEN ROMÉU ET JULIETTE

IRINA LUNGU I JEAN-FRANÇOIS BORRAS CANTEN ROMÉU ET JULIETTE

Irina Lungu Juliette Foto Sauer font original Donaukurier Avui us porto una representació una mica endarrerida en el temps si ho comparem amb tot allò que podríem qualificar de rabiosa actualitat, tot i que estic parlant d’una representació de principis de l’estiu provinent del Festival de Ingolstadt, un festival sense gaire pretensions que organitzen una òpera cada any i en aquesta ocasió han…

[automaticvr]

“360° Figaro” is a music film shot in virtual reality: an opera scene, for the first time conceived and staged exclusively for this new medium, live performed both vocally and instrumentally, recorded by a binaural sound recording technique. A series of scenes – coherent in itself – will be taken and shot from the beginning of Act II of Mozart’s Le nozze di Figaro. The viewer will be placed right in the centre of the performance which is staged exclusively for him. Starring the soloists: Jacquelyn Wagner (Rosina), Olena Tokar (Susanna), Matthias Hausmann (Graf Almaviva) and Valentina Stadler (Cherubino)

[cancersfakianakis1]

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Publication date: 12 June 2017 Source:Cancer Cell, Volume 31, Issue 6 Author(s): Detian Yuan, Shan Huang, Emanuel Berger, Lei Liu, Nina Gross, Florian Heinzmann, Marc Ringelhan, Tracy O. Connor, Mira Stadler, Michael Meister, Julia Weber, Rupert ��llinger, Nicole Simonavicius, Florian Reisinger, Daniel Hartmann, Rüdiger Meyer, Maria Reich, Marco Seehawer, Valentina Leone, Bastian Höchst, Dirk Wohlleber, Simone Jörs, Marco Prinz, Duncan Spalding, Ulrike Protzer, Tom Luedde, Luigi Terracciano, Matthias Matter, Thomas Longerich, Percy Knolle, Thomas Ried, Verena Keitel, Fabian Geisler, Kristian Unger, Einat Cinnamon, Eli Pikarsky, Norbert Hüser, Roger J. Davis, Darjus F. Tschaharganeh, Roland Rad, Achim Weber, Lars Zender, Dirk Haller, Mathias Heikenwalder Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells caused JNK-mediated cholangiocellular proliferation and oncogenic transformation. Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or JNK inhibition reduced cholangiocellular pre-neoplastic lesions. Liver-specific JNK1/2 deletion led to tumor reduction and enhanced survival in Akt/Notch- or p53/Kras-induced ICC models. In human ICC, high Tnf expression near ICC lesions, cholangiocellular JNK-phosphorylation, and ROS accumulation in surrounding hepatocytes are present. Thus, Kupffer cell-derived Tnf favors cholangiocellular proliferation/differentiation and carcinogenesis. Targeting the ROS/Tnf/JNK axis may provide opportunities for ICC therapy.

Graphical abstract

Teaser

Yuan et al. show that mitochondrial dysfunction and oxidative stress in the liver increase tumor necrosis factor (TNF) expression by Kupffer cells to cause JNK-mediated cholangiocellular proliferation and transformation. The ROS/TNF/JNK axis may be an effective target for intrahepatic cholangiocarcinoma therapy. http://ift.tt/2tgcPZU

[automaticvr]

“360° Figaro” is a music film shot in virtual reality: an opera scene, for the first time conceived and staged exclusively for this new medium, live performed both vocally and instrumentally, recorded by a binaural sound recording technique. A series of scenes – coherent in itself – will be taken and shot from the beginning of Act II of Mozart’s Le nozze di Figaro. The viewer will be placed right in the centre of the performance which is staged exclusively for him. Starring the soloists: Jacquelyn Wagner (Rosina), Olena Tokar (Susanna), Matthias Hausmann (Graf Almaviva) and Valentina Stadler (Cherubino)