#VSMC

[molsons112000]

So stress causes mucus production, which inhibits breathing. Stress creates fat resistant. It prevents you from losing weight. It also causes increase body toxicity.

National Institutes of Health (NIH) (.gov

https://pubmed.ncbi.nlm.nih.gov › ...

Glucocorticoids and vascular reactivity

by S Yang · 2004 · Cited by 372 — Increased cortisol response has been associated with an increase in arterial contractile sensitivity 

Yes, cortisol can cause 

vasoconstriction

. Cortisol is a hormone that can cause blood vessels to 

constrict

 when someone is stressed. Cortisol also works with catecholamines to maintain 

vascular tone

, 

endothelial

 integrity, 

vascular permeability

, and the distribution of water within the 

vascular

 compartment. Cortisol also potentiates the vasoconstrictor effects of catecholamines. 

Oxford Academic

The role of corticosteroids in the regulation of vascular tone

Since corticosteroids are transcription factors, it is possible that they induce synthesis of receptors for vasoconstrictors. Coupling of these new receptors to the signal transduction pathway that mediates cell contraction might be involved in the potentiation of vasoconstrictor action by corticosteroids.



pubmed.ncbi.nlm.nih.gov

Steroids - PubMed

Cortisol acts in concert with catecholamines to maintain the vascular tone, endothelial integrity, vascular permeability, and the distribution of total body water within the vascular compartment. It also potentiates the vasoconstrictor effects of catecholamines.

ahajournals.org

Sustained Elevation of Serum Cortisol Level Causes Sensitization of ...

The mechanism for the enhanced coronary vasoconstricting responses caused by sustained elevation of serum cortisol level is apparently attributable to VSMC hyperreactivity that exceeds endothelial vasodilator capacity, a consistent finding with our previous studies.



Prime Heart and Vascular

The Link Between Stress and Hypertension

When you're stressed, your heart rate speeds up drastically and your blood vessels constrict. This is the result of a hormone called cortisol. It's a natural ...

Corticosteroids

 are transcription factors that may cause the synthesis of 

receptors

 for vasoconstrictors. These receptors may then be coupled to the signal transduction pathway that mediates cell contraction, which may potentiate the vasoconstrictor action of corticosteroids. 

Cortisol levels in the blood, urine, and saliva typically peak in the early morning and decline throughout the day, reaching their lowest level around midnight. For most tests that measure cortisol levels in the blood, the normal ranges are:

6 a.m. to 8 a.m.: 10 to 20 micrograms per deciliter (mcg/dL)

Around 4 p.m.: 3 to 10 mcg/dL 

Sustained elevation of serum cortisol levels can cause enhanced coronary vasoconstricting responses. This is apparently attributable to 

VSMC

 hyperreactivity that exceeds endothelial vasodilator capacity. 

Yes, cortisol can increase mucus production. For example, one study found that longer viral shedding is associated with more mucus production and slower nasal clearance. 



NCBI

Basal Salivary Cortisol Secretion and Susceptibility to Upper ...

Jan 14, 2016 — 3.3. Association of salivary cortisol with illness severity in infected participants. As expected, duration of viral shedding was correlated with both objective markers of illness. Specifically, more days of shedding was associated with greater mucus production (r = . 35, p = . 001, n = 450) and slower nasal clearance (r = . 12, p = . 009, n = 450). However, as indicated by Table 3, the relation of cortisol with duration of viral shedding did not extend to severity of clinical illness.

Cortisol is a 

stress hormone

 that can cause 

physical changes

 like faster breathing, increased heart rate, and heightened 

alertness

. Anxiety can also cause excessive mucus, which is usually found in the back of the throat or nose. This can make it feel like you need to cough or hack to remove it, and can cause irritation or make breathing more difficult. 

High cortisol levels can also cause other symptoms, including:

Rapid weight gain, especially in the face, chest, and abdomen

A flushed and round face

High blood pressure

Osteoporosis

Skin changes, such as bruises and stretch marks

Muscle weakness

Mood swings

, such as anxiety, depression, or irritability

Headaches 

A doctor can provide a formal diagnosis through a blood, saliva, or urine test. 

Cortisol Can Lead to Weight GainCortisol stimulates your fat and carbohydrate metabolism, creating a surge of energy in your body. While this process is essential for survival situations, it also increases your appetite. Additionally, elevated cortisol levels can cause cravings for sweet, fatty and salty foods.Feb 12, 2020



https://www.orlandohealth.com › ...

How Too Much Stress Can Cause Weight Gain (and What to Do ...

[thewisestwizards]

My haul from the Vinegar Syndrome Halfway to Black Friday sale. The VSMC magnet is surprisingly heavy duty. Glad I picked up Censor before it sold out, it’s one the best horror movies in recent years.

[rnomics]

Single-cell #RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm

CONCLUSION: A variety of VSMCs phenotypes are involved in the formation of aortic aneurysm. T-cell-like VSMCs, macrophage-like VSMCs, and mesenchymal-like VSMCs play pivotal roles in this process. Video Abstract. https://pubmed.ncbi.nlm.nih.gov/37189183/?utm_source=dlvr.it&utm_medium=tumblr&utm_campaign=None&utm_content=1RYYbE7j9SUSBe_aHniaI_J1MQIFIBbfLuFxoWdLNMNDzVVIWF&fc=None&ff=20230518031416&v=2.17.9.post6%2086293ac

[myramanibog]

View this post on Instagram

A post shared by myra manibog (@myramanibognew)

Listen to the full song on Spotify or YouTube. https://youtu.be/Y_pHzr4u7VQ #alekzandra #problemangpuso #vsmc https://www.instagram.com/p/CZUPgzrpeLp/?utm_medium=tumblr

[jeffgerstmann]

When did you first start messing with emulation? I found out about NESticle in 1998 thanks to my friend’s brother. Did you follow the Bleem/Connectix stuff closely at the time?

Like... 1995-6 or so? Back when all you could successfully run was Game Boy stuff. Back when VSMC was coming out and Pasofami played NES games, but everything was yellow unless you registered it.

[rnomics]

Nucleolin Regulates Pulmonary Artery Smooth Muscle Cell Proliferation under Hypoxia by Modulating #miRNA Expression

Hypoxia induces the abnormal proliferation of vascular smooth muscle cells (VSMCs), resulting in the pathogenesis of various vascular diseases. #RNA-binding proteins (RBPs) are involved in a wide range of biological processes, including cell proliferation and responses to hypoxia. In this study, we observed that the RBP nucleolin (NCL) was downregulated by histone deacetylation in response to hypoxia. We evaluated its regulatory effects on #miRNA expression under hypoxic conditions in pulmonary... https://pubmed.ncbi.nlm.nih.gov/36899956/?utm_source=dlvr.it&utm_medium=tumblr&utm_campaign=None&utm_content=1Zap-74u4XbiV7x0qz5lToBuxtoq00qwwHZUuXSRQOsim8UYds&fc=None&ff=20230316100630&v=2.17.9.post6%2086293ac

[xtruss]

Research Team At NYU Tandon (Polytechnic University, Brooklyn, New York) Discovers Mechanical Basis For Abdominal Aortic Aneurysm

— January 26, 2022

BROOKLYN, New York, Wednesday, January 26, 2022 – Abdominal aortic aneurysm (AAA) is a complex and life-threatening vascular disease with high incidence worldwide. Termed the silent killer, most AAAs are asymptomatic, often going undetected until rupture, and involve a poorly understood set of mechanical and biochemical events. Epidemiologic studies have established associations between AAA and both vascular inflammation and increased stiffness. That the latter is concomitant with aging explains, in part, why AAA affects almost exclusively those over 65 years of age.

Evidence suggests that abnormal acclimation of vascular smooth muscle cells (VSMC) to biomechanical perturbations, such as increased circumferential stress in hypertension, can stimulate AAA development. However, there is a paucity of knowledge of the molecular drivers of altered mechanobiological behaviors of VSMC. Understanding these might provide promising targetable signals that could repress AAA progression and limit rupture incidents.

Now, researchers at NYU Tandon (Polytechnic University) and NYU Langone have demonstrated mechanobiological changes in VSMC and identified a key ion channel that is involved in the development of AAA. In a new study, in Nature Communications, they describe the means by which VSMC gradually adopt a solid-like state by upregulating cytoskeleton crosslinker, α-actinin2, which powers the mechanosensitive ion channel Piezo1.

“Our team applied biomechanical engineering to study aneurysm pathology,” explained Chen. “In contrast to the extensive study of aorta wall properties, we explored how a cell’s mechanical sensitivity, or ‘mechanosensation’ to mechanical stimuli presents an innovative perspective in revealing disease pathogenesis and progression mechanisms.”

The researchers measured misshapen VSMC with a novel ultrasound tweezers system and a single-cell RNA sequencing technique. Their findings pointed to Piezo1, which critically regulates VSMC mechanical sensitivity. They also found that inhibition of Piezo1 prevents mice from developing AAA by alleviating pathological vascular remodeling. The findings concluded that deviations of mechanosensation behaviors of VSMC is detrimental for AAA and identifies Piezo1 as a novel culprit of mechanically fatigued aorta in AAA. This could lead to new mechano-medical approaches to treating this devastating cardiovascular disease.

This research was led by Professor Weiqiang Chen’s Applied Micro-bioengineering Laboratory at NYU Tandon (Polytechnic University), and Professor Bhama Ramkhelawon’s Lab at NYU Langone. The research was supported by the National Institutes of Health and the American Heart Association.

The study, “Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1,” can be found at www.nature.com/articles/s41467-021-27874-5

[corvology]

yang is making me consider dropping out just with his garbage powerpoints BESTIE WHAT THE FUCK ARE VSMCS ? WHY DO YOU SLAP RANDOM ABBREVIATIONS EVERYWHERE????

[rnomics]

Long Noncoding #RNA SBF2-AS1 Promotes Abdominal Aortic Aneurysm Formation through the #miRNA-520f-3p/SMARCD1 Axis

Abdominal aortic aneurysm (AAA) is a chronic vascular inflammatory disease. The regulatory mechanisms during AAA formation remain unclear. Bone marrow stem cells (BMSCs) are pluripotent cells capable of regulating the progression of various diseases by delivering exosomes and exosomal l#ncRNAs. In this study, we investigated its function in AAA by isolating BMSC exosome-derived l#ncRNA SBF2-AS1. The results showed that BF2-AS1 could be transferred to vascular smooth muscle cells (VSMCs) and human... https://pubmed.ncbi.nlm.nih.gov/35968497/?utm_source=dlvr.it&utm_medium=tumblr&utm_campaign=None&utm_content=1RYYbE7j9SUSBe_aHniaI_J1MQIFIBbfLuFxoWdLNMNDzVVIWF&fc=None&ff=20220817051914&v=2.17.7

[biomedres]

Journals on Psychology - BJSTR Journal

Targeting Hyaluronan in Vascular Diseases with Special Reference to Diabetic Macroangiopathy by Annele Sainio* in Biomedical Journal of Scientific & Technical Research https://biomedres.us/fulltexts/BJSTR.MS.ID.002269.php Vascular Extracellular Matrix (ECM) is a dynamic structure, which regulates blood vessel morphogenesis, provides organizational stability, and modulates various aspects of cell behavior [1]. Hyaluronan (HA) represents one of the most abundant macromolecules of the vascular wall. One of its main functions is to maintain blood vessel integrity [2]. Thus, any alteration in the metabolism of HA can predispose to the development and progression of atherosclerotic vascular diseases including diabetic macroangiopathy [3,4].HA is a multifunctional linear glycosaminoglycan, composed of repeating disaccharide units of D-Glucuronic Acid (GlcUA) and N-Acetylglucosamine (GlcNac) (Figure 1). It is synthesized by specific plasma membrane glycosyltransferases, namely Hyaluronan Synthases 1-3 (HAS 1-3) [5]. The HASes exhibit distinctive enzymatic properties and use the cytosolic pool of UDP-sugars as substrates. The functions of HA are versatile and partly depend on its molecular size. For example, High Molecular Weight (HMW) HA possesses anti-inflammatory and immunosuppressive properties, whereas Low Molecular Weight (LMW) HA is a potent pro-inflammatory molecule [6]. The action of HA is also greatly influenced by its interactions with other ECM macromolecules such as lecticans, and cell membrane receptors, e.g. Cluster Determinant 44 (CD44) [7,8]. The turnover of HA is tissue specific and its half-life varies from 12 to 72 hours [9]. While HASes are responsible for the synthesis of HA, Hyaluronidases (HYALs) are enzymes responsible for its degradation. HA is expressed in every type of blood vessel, and for example in arteries it can be detected in all three layers, mostly in the intima and adventitia and also in small amounts in the media. By maintaining intact endothelial glycocalyx, HA displays a pivotal role in vascular biology [10,11]. Overexpression of HA is characteristic for diabetic macroangiopathy [12]. Accumulation of HA occurs in response to hyperglycemia (Figure 2). This results in enhanced Vascular Smooth Muscle Cell (VSMC) proliferation and migration, and altered inflammatory cell adhesion properties [3,13].  For more articles Journals on Psychology please click here bjstr Follow on Twitter : https://twitter.com/Biomedres01 Follow on Blogger : https://biomedres01.blogspot.com/ Like Our Pins On : https://www.pinterest.com/biomedres/

[brunoazzanibraga]

Some day you will be mine. • Um dia Vsmc será minha. •• Art by Bruno Braga Follow me on Instagram: @_azzani • #133 #nankin #inkstudies #sketchingart #doodleart #doodle #sketchbook #sketch #graphicdesign #graphicdesigner #designgrafico #ilustracion #ilustration #ilustração #360daysofsketching @drawing.expression @designground #designground #graphicdesigndaily @artwork_now

[jeffgerstmann]

When did you become aware of hardware emulation?

I probably started seeing Game Boy emulation around 1996, I’d guess? Pasofami came out and was trying to do NES stuff, VSMC was an incredibly early SNES emulator... it wasn’t until NESticle came out that things really kind blew wide open. MAME was on my radar around that same time.