#The Fallopian tube get blocked

[reaperexe]

Doc ♡

summary : a gynac visit with your lover and his antics will obviously be fun.

warnings : none just fluff <3

Going to the doc with him was a task in itself. it was just a routine check up but he still insisted in accompanying you.

He seemed to be having a new 'living healthy' mindset recently, being more into vitamins, healthy foods and keeping the body clean and healthy and fussing over you to do so too.

Going as far as cancelling all his plans for the day to be there with you, promptly telling anyone that called to ask about him saying "She needs me today" as you facepalm at his serious expression.

He makes sure you're well fed and stresses on your behalf. Makes sure to ask the important questions as well "the doctor? its a women right?" with the most concerened face ever and you can't tell how hard you tried to not face-palm then and there.

Starts packing hours before the appointment cause "we should be there on time" he says. Drives there early too, the receptionist is staring at both your faces confused as to why you're he's acting as if a normal checkup is a complete crisis.

As he sits at the waiting area he looks around at the various health and informative posters on the wall along with the various models of reproductive system in the room.

He points at the fallopian tube, lighting up as he says "Hey! I know that one, you told me about it" as you smile along like a proud parent.

When you two do enter the doctors office, he sits with his arms folded only because you begged him outside to not pull out his intricate notebook and pen he prepared beforehand, his justification being "but baby I need to note down all the important stuff" with the biggest puppy eyes.

It took all your willpower to still say no to him and you could swear you heard the man whimper before putting the notebook away.

He sits infront of the doctor listening intently to every word she says.

It was surprising to you too how much he knew about you, the questions he asked were also some things you might have forgotten to ask but he remembered perfectly.

Fusses over you after you come home and makes sure all the things that the doctor recommended are implemented, goes as far to research meals that would be healthy for you and your body.

A short one but I needed to get out of the block :,(

[russellsppttemplates]

How much of their struggle to have a babies did y/n and Lance's families know? Like, did they keep things more between themselves, or did they share with few people( like y/n mom or Choe)?

Tw: infertility, IVF treatments

"Do you want me to go with you?", Lance wondered, "you wouldn't mind?", you replied, "of course not, sweetheart. We're in this together", he kissed your knuckles, "besides, your mother texted me yesterday saying that she had baked those little cakes I love", he smirked.

"Mom", you called, "remind me again of what happened when aunt and uncle were trying to have a baby", you asked. Having someone in the family with a similar diagnosis to yours meant that the baby questions were somewhat carefully thought through before someone asked them, so asking your mum, you figured, would be safe.

"Oh, well, they tried for a really long time, she took some hormones to help with her ovulation, because she had a low egg count", she said, "at the time, they also saw a specialist but the treatments were not an option for her, but around a year, a year and a half later, your cousin arrived", she finished, "something on your mind?".

"We've been doing the whole calendar thing and ovulation sticks, but it's yet to work", you admitted, "we both have healthy counts, so it's something else, but this really sucks, you know?", you blurted, feeling her hug you to her side, "I'm sorry, darling, but it will all work for the best, I'm sure of it", she kissed your forehead, "besides, it doesn't look like it's a job to try, you know? You have a very handsome looking husband", she smirked as you swatted her hand, "besides, as long as there is love between you two, you'll be good".

.

As much as you didn't feel like shouting out to everyone in the world that you would be undergoing fertility treatments to start building your family, you knew you and Lance needed support. Not because you were ashamed or embarrassed, but it was still a personal matter that involved your families, and having their support would be good to fall back on.

When you arrived at your parents' house, your father was quick to get some drinks out while your mother made some tea and got the little cakes to the coffee table, "so, Lance, everything fine at work?", you dad began, "yes, it's been going really well, actually", he smiled talking about a few new topics and some they had discussed the previous visit you had payed them.

"You're a bit quiet, darling, is everything okay?", your mother noticed, rubbing your thigh from her seat by your side, "Actually, I've been meaning to tell you something, we have, actually", you gulped, "We have been to Dr. Marlin's office again because we've been having trouble with trying for a baby, and as it turns out, it's a blocked fallopian tube, so things aren't ending up where they should end up and it makes the whole thing pretty much impossible this way",

"Oh, Y/N, I'm sorry", she got up to hug you before your dad gestured the sign you've had since you were little. You sometimes got scared when going to school, so whenever you were already inside the gate and he couldn't give you another hug after dropping you off, he would slightly cross his arms on his chest as if he was hugging you and you would do the same before stretching out your pointer finger as he did the same, pretending you were touching his. It had become a silly thing when you were little, but it quickly became your thing.

"We are going to begin the treatments soon, hopefully", Lance took over, "Dr. Marlin just needs to get the cycle up to speed and sorted out, and then we begin them when Y/N is comfortable enough", Lance noted, absentmindedly grabbed your hand in his, his thumb rubbing the skin.

"Honey, if there is anything we can help you, help you both", your father said, "let us know. You're not going through this alone", he smiled.

.

"How are you doing with all of it?", Chloe asked her younger brother as she bounced her little one in her arms. Scotty and Chloe had finally felt okay enough to welcome visitors to meet the new addition to the Stroll-James family and you and Lance also found the time to vist them between both of your schedules.

"I've been good. I think now that we know what is happening, we know how to deal with it. We kept trying and it wasn't working, so to know why it wasn't working and that there is a way to help it's comforting", he admitted, "Y/N has been good, too, I think. I've made sure she's telling me how she feels and whenever things get too much so we can work it out together, like a team", he smiled, stretching his arm and softly touching his nephew's cheek.

"I was so scared to invite you because I didn't want Y/N to feel bad about it. I know it's stupid to try and put myself in her position when I've never had issues, but I didn't want either of you feeling bad", Chloe added, "thanks for your consideration, but I think it's fine", Lance smiled as he heard Scotty's footsteps and your giggles coming their way.

"I'm proud of you, Lance", his sister complimented, "of the man you've become. I'm not saying I doubted you'd be like this, but it's a pleasure to see you like this", she nudged him, seeing her husband and you walking into the living room.

"Hey, look who's up!", you cooed at the little bow, "can Auntie Y/N have a cuddle? It's okay if it's not, though", you checked with your sister in-law, "of course it's okay, it gives me time to go to the bathroom!", she cheered, passing her son to your arms, "hello, sweet boy, you're wide awake now, aren't you?", you smiled, touching his soft cheek and seeing his light coloured eyes now open, "here", you heard Lance call you, arranging the space next to him on the sofa so you could sit next to him, wrapping his arm around your shoulders, "are you feeling good?", he wondered, checking in as you smiled at him, "yes, I am. Thank you for checking in", you kissed his cheek, "and this is good practice, isn't it? Isn't it, gorgeous boy? Yes, it is", you cooed at your nephew, hoping that this was a practice moment for what was to come.

(Thank you for submitting an ask 🤍)

[figmentforms-the-human]

I’m finally starting my first round of IVF injections for egg retrieval and I can’t help but feel like my ruined fallopian tubes are the blocked Suez Canal and my eggs are the shipping boats traveling around an entire continent just to get to what WOULD HAVE been a very close destination if not for a random bullshit occurrence.

I should have named my tumor the Ever Given

[affectionatepanda]

I recently had a diagnostic laparoscopy because my doctor and I were sure I had endometriosis. None was found (although I’m not entirely convinced it’s not the problem but I’m no expert) but what was found was just… So much scar tissue. Things were stuck to other things and I had an organ twisted out of place. The biggest thing for my long term health (I think) that was found- and this might be TMI but really is anyone going to read this?- my fallopian tubes are completely blocked. Meaning I can’t have children unless I either get that treated or use IVF. I didn’t particularly want to have children, at least not by using my body. But it’s weird knowing that it’s not even really an option for me. I’m not sure I’ve really processed this information; I just feel numb about it. Apparently blocked fallopian tubes are a fairly common cause of infertility. Infertility. Is that something I have to identify with now? Do I have to say I’m infertile? I’m really adding to my list of adjectives over here. Chronically ill, disabled, mentally ill, lesbian, nonbinary, neurodivergent… infertile? I guess I am. It’s such a strange feeling. I don’t know what to do with it. Oh, and we don’t know exactly what caused the scarring. My doctor’s best guess was some sort of infection but I don’t remember ever having any kind of infection that would cause this. I thought this would give me answers but I feel just as confused as before. But I’ve deemed “fixed” and he said I only need to be seen for routine screenings anyone my age would get. Maybe I’m supposed to be satisfied with that. Maybe I want too much out of my doctors, I don’t know. All I know is I don’t really… have anyone to talk to about this. Not anyone who knows what to say. It’s fine though, I don’t even know what I want to hear.

[dontmeantobepoliticalbut]

The June 24, 2022 Dobbs v. Jackson landmark decision by the United States Supreme Court held that the Constitution of the United States does not confer the right to abortion. This decision returned to individual states the power to regulate any aspect of abortion not protected by federal law. Since this ruling, multiple states have limited or completely banned abortion care for people who are pregnant. In at least nine states, abortion is blocked with no exceptions for rape or incest.

Multiple states have banned abortion after 18, 15, or even 6 weeks gestation. These time restrictions make it impossible for patients to use medical information from ultrasounds and/or genetic testing, available later in pregnancy, to determine if a fetus has an anomaly and/or a life-threatening or lethal condition.

These abortion restrictions and laws permitting any citizen to sue anyone “aiding or abetting” an illegal abortion for up to $10,000 has created uncertainty and fear among health care providers trying to provide medical care to pregnant patients experiencing miscarriage, tubal or ectopic pregnancy (when the embryo implants in the fallopian tube, where it cannot become a full term pregnancy; can be lethal to the mother if not treated promptly and correctly), or those who need prenatal genetic counseling. Clinicians are unclear where the lines stand between providing care and committing a felony that could equal jail time, and this means that pregnant people aren’t getting the appropriate and timely care they need, even outside of a healthy, viable pregnancy.

But did you know that the Dobbs decision has also prevented non-pregnant women from receiving the medications they need to treat lupus, rheumatoid arthritis, and other conditions treated with medications like methotrexate?

Chris Stallman, MLS, MS, is a certified genetic counselor, an expert in medication impact during pregnancy, and a Clinical Instructor of Pharmacy Practice-Science at the University of Arizona R. Ken Coit College of Pharmacy. “Methotrexate is a medication used to treat many conditions, including lupus, rheumatoid arthritis, Crohn’s disease, and other autoimmune diseases. If a person who is pregnant uses methotrexate, it could increase the chance of miscarriage, birth defects, and other issues in pregnancy or after birth.”

For this reason, girls and women of child-bearing age who are taking methotrexate as treatment for their autoimmune or other diseases are not able to take methotrexate – even if they are not pregnant.

This critical problem is not hypothetical – treatment with methotrexate has already been withheld from female, non-pregnant patients with serious medical conditions in multiple states.

A 48-year-old woman in Tellico Plains, TN received an automated call from her CVS Pharmacy in July 2022 indicating that her prescription for methotrexate wouldn’t be refilled. This patient, who has inflammatory arthritis and a neuromuscular disease called myasthenia gravis, stated that methotrexate allowed her to resume simple, yet previously painful tasks like putting on her pants and rolling over in bed.

In June 2022, not 24-hours after the Dobbs ruling, a patient in Maryland who has Crohn’s disease received a call from her insurance company indicating that methotrexate, used to treat the chronic inflammation and pain associated with this condition, would no longer be available to her.

Within a week of the Dobbs ruling, a woman in Virginia who has Lupus received a letter from her doctor’s office indicating that it was pausing all prescriptions and refills of methotrexate because of the Supreme Court decision on abortion. Before taking methotrexate she experienced flares of Lupus so severe that she had trouble walking and needed to use a shower chair to wash.

Another woman from Missouri had been taking methotrexate to treat rheumatoid arthritis. When she went to the pharmacy to pick up her refill she learned from the pharmacist that they needed a specific direction from her doctor that the medication would not be used for an abortion. The pharmacy, Walgreens, confirmed with this customer that they do not require the same procedure from their male clients.

A 14-year old girl in Arizona was denied a refill of methotrexate to treat her debilitating rheumatoid arthritis and osteoporosis. Her angry physician tweeted that her patient was denied this critical medication because she was female. The withholding of life-saving or -altering medications from the women who need them has forced some of them to consider surgical sterilization.

Could denying women of childbearing age (who may or may not be sexually active, fertile, heterosexual, or pregnant) methotrexate be just the beginning of problems for women who need prescription or over-the-counter medications? Stallman says, “This certainly could lead to more medication denials – and not just for people who can get pregnant. If my husband or children need medication that could increase risks to a pregnancy, would they be denied the medication simply because they live with a person who could get pregnant? Will health care providers have to stop handling or dispensing such medications if they or their partner could get pregnant? And before saying ‘that will never happen’, remember that is what people said about the overturning of Dobbs. We don’t know how far this will go.”

Let’s take this thought experiment a step further. Is it possible that young girls will have to present a letter from their pediatricians indicating whether they’ve started having periods before they can receive the medications they need? Will adult women have to present written proof of tubal ligation, menopause, or infertility from their physicians before filling their life-saving medications? Will other medications that can affect the health of a fetus, even the highly regulated acne medication Accutane, require such additional proof? Could pharmacies use the data they have on prior purchases, like tampons and lubricant, to determine if a woman may be of child-bearing age and/or is sexually active?

The Dobbs decision is just the beginning of our government interfering with womens’ bodies, their personal choices, and their medical care. This decision is already impacting health care outside of pregnancy and could force women and their family members to disclose personal information about their fertility, sexuality, sexual and medical history with pharmacists, medical systems, the government, and the databases that all of them use. Our federal government must act swiftly to ensure that this decision doesn’t lead to further government overreach, discrimination, interference in proper medical care, and tragedy.

[eggtartz]

I think I accidentally sent my request for you to another account thinking it was yours a few days ago🥲 but just in case i did it was supposed to be a shinichiro x fem reader. Where shin and reader are married and have been trying for a baby but haven’t had any success so they end up going to the doctors where they find out that reader can’t have kids. It makes her depressed because she believes that since shin is a big family type of guy that he will leave her. Shin starts to notice how distanced she’s been and comforts her and assures her that he won’t leave her.

a/n : love, live, laugh with angst uh i love writing angst, i suddenly become divorced mother with two kids anyways thankyou for requesting anon 🫶🏻

masterlist

you have married shinichiro for two years now. after discussing and suggestions and of course teases, the two of you finally settled down to have children of your own. so shin did everything he possibly can to candle night dinner to vacations to renting a love motel so you two can work on having a kid.

however it's been almost a year of trying to have a baby, you've grown concerned if having a baby is possible for you. so while shin went to work, you went to the nearest clinic to have a checkup.

what the results that the doctor gave you was heart shattering.

"so ms sano, unfortunately you are infertility. if you could see the results here your dallopian tube obstruction is the problem. if it's blocked or scarred, fallopian tubes can prevent sperm from reaching the egg" the doctor explain to you while you're two seconds from crying.

"meaning doctor?" you shakingly asked.

"it means ma'am that your husband sperm won't be able swim to it's supposed direction because it's blocked. that also mean you cannot get pregnant" you already was at the verge of tears and you started crying there. you sobbed uncontrollably at the chair while the doctor went to rub your back. "there's adoptions if you want ma'am. don't be too sad"

sure adoption was available but it doesn't feel the same, the child isn't your blood and flesh. you were always excited to feel those day where the baby would kick your stomach or you would lay at the hospital pushing the baby out. it's different, everything's different.

moreover, shin wanted a big family. god knows what shin's gonna say since he always wanted a big family. is he gonna leave you for someone fertile? for someone who can give him a big family like he always wanted?

you left the clinic with your mind clouded, heart heavy. you kept thinking that shin would surely leave you, you figured you can't tell the news to your husband now. you went home, cook dinner as usual and everything as usual.

when your husband came home, you weren't there to greet him like usual so he thought you feel asleep or was too tired. he saw you cooped up in the bed, reading a book about pregnancy.

"hey babe.. how's your day?"

"fine"

"hm? you tired?"

"a little bit. you wanna eat something? i can reheat dinner" you forced your body to move from the bed but you husband pushed you back gently. "no need sweetheart, i already ate. how about i go shower and we cuddle yeah?" you nodded at his suggestion, shin getting confused at your reaction. shin noticed how your responses are short and lack emotions. shin noticed how your body is stiff and tense. shin notices how your face doesn't brighten up at the idea of desserts again.

what was it? what happened?

he took a cold shower to clear up his head. you have behaved like this for three days now and your husband has had enough. shin didn't wanted you two to drift away just because you can't communicate. shin wrapped a towel around his waist and another towel drying his hair. he was about to take his hoodie out until a paper fell.

what?

"y/n l/n. explain this" shin threw the paper right in front of you who was watching tv. you were horrified when you recognized where the paper belonged and what it contains. it's now or never.

"i- i went for a checkup.. and this.. is the result" your voice sliced through the silence of the night, it was slow but audible enough. "i.. i can't get pregnant shin.. i- i can't.." you continued, struggling to not pathetically cry. shin kneeled down and touched your face to look at him. "was this reason you're distancing yourself from me?"

"yes! i- i know you wanted a big family and.. and i can't even give you a child like anyone else! you'll.. you'll leave me but.. but i can't lose you.. i can't.." you hysterically sobbed now the emotions you kept away was flowing, not showing any signs it'd stop.

"y/n. look at me" you finally looked at his face thriughy blurry eyes.

"i love you. and i would never do that. it's okay if we can't have a big family, not everything needs to be done. i would never leave you just because you can't get pregnant. i love you y/n, no matter what" your husband soothing voice reached you that made your sobbing even worse. shin reached your face and kissed your lips, muffling your cries.

"im sorry.. i should've-"

"it's okay baby, it's just.. don't keep everything to yourself okay? im your husband, we can talk you know? don't do that again yeah?" your husband asked while you nodded again, still crying. your sobs went down after a while and shin lifted your body to your shared bedroom.

you hugged him tighter that night and he held you closer, none of you willing to let go.

[avesblues2]

Update after procedure.

Finally feeling better, just enough, to type an update. I'm sensitive to anesthesia so it makes me pretty nauseous! I'm still super tired and will nap after this text lol!

The procedure was about two hours. I didn't get to hear the results because I was knocked out but the doctor contacted my husband and gave him an overview, which i can call to get more details or what to my post op.

He said it was a very bad case of endometriosis. I was/am diagnosed with SEVERE stage 4 endometriosis. However, he was able to remove all of it.

The cyst in my ovary was huge but he removed it from the root and my ovary is still there! No cysts on the other ovary.

I had severe scar tissue along my whole uterus and in other places. Along with adhesions EVERYWHERE. My Fallopian tubes were also blocked because of this but he cleared them without hurting the tubes in anyway! So my tubes are now cleared.

He was able to get everything completely out.

However, this information I will find out at post op is when we can start trying! Because it was so severe, he does want to a wait a little bit but not sure what that timeline is! he wants me to take it easy for the next weeks because of the severity and just relax and I should stop feeling nauseous by tomorrow as well.

The Lord has answered my prayers

-the staff was so incredible, the most loving and kind and supportive hospital staff I've ever countered (I've had three other surgeries lol)

-The lord allowed me to keep my tubes and ovaries!

-my tubes are cleared

-the endo is gone!

Downside, endometriosis does come back however we will be going over different methods and medications to minimize it.

Finally, he is EXTREMELY optimistic I can now get pregnant with ease!

Thank you for your prayers. All the love and support I got brings me to tears, even right now. I'm so overwhelmed with peace and joy and feel so so loved. Thank you thank you

[eversailedinafirefly]

hey there uterus-burdened folks, i’m in need of some advice??

went in to my gyno for a pretty standard IUD replacement and because I was having some v unpleasant cyst symptoms (not entirely abnormal) i asked him to poke around up there with his ultrasound a lil longer. turns out, ya girl has a blocked fallopian tube and is getting fast-tracked to an endo diagnosis and a potential laparoscopy

except not that fast, bc it’s the Netherlands and healthcare is cheap and pretty good but decidedly not fast. and in the mean time I’m just in more and more pain (especially in the mornings) and my stomach is all out of whack and bloated and eating is harder than I’d like it to be. plus like, the crushing mental realization that something about my body is fundamentally wrong again*, the girl who fuckin hates medical procedures now gets another metric shit ton on my plate, and this shit will have a decided impact on the future i’m trying to build with a beloved partner. ya know, little things.

so anyway, if anyone has any advice on just short term pain and symptom management for this, it would be really helpful. I’m just tired of dealing with my body and if anyone can make me hate it less rn I’d appreciate it ❤️

*ya girl ALSO has MS because if there is a god they decided to fuck my life in particular

[portlandvalentine]

Oh hi, if anyone’s still reading. I worked at the pharmacy for 11 miserable months, but was finally able to transfer to a new job at the hospital. There was a whole thing where my boss at the pharmacy actually tried to block my transfer, claiming that if I left it would harm patients, because everyone else would be more busy and a pharmacist might make a mistake and kill someone and that would be on me! I was a fucking pharmacy cashier! I mean that job title doesn’t really convey my MANY duties at the pharmacy; it was more like I was running the front end of the pharmacy, distributing medications, being the first and only human most patients dealt with directly/being the punching bag for hundreds of patients every day, etc. And it’s true that me leaving created more work for others, but guess what, that’s not my fucking problem!

I had to get the union involved and eventually I was able to start my new job. I’ve been there almost three months now and it is pretty much awesome! I mean, as far as jobs go. I work as a hospital transporter now. Basically I move medical equipment, blood, specimens, etc around the hospital. I don’t have to deal with patients! Most of my coworkers primarily move patients and they (potentially) make a little more money for it, but after the pharmacy I don’t ever want to deal with patients again. I work alone and I’m walking around pretty much nonstop all day. I walk 10-13 miles a day and I love it. I’m often moving heavy ass hospital beds long distances and I feel like I’m getting so strong. I go to basically every single part of the huge hospital campus. It’s routine enough to be comfortable, but at the same time varied enough to keep things interesting. An app assigns me a job, I do the job, then the app assigns me my next job. There’s no balancing 13 different urgent tasks at a time like at the pharmacy while also being yelled at by patients. Occasionally I get to transport an entire organ or a severed limb! Those are my favorite jobs: if the app is sending me to pick up a specimen in the OR I know it’s gonna be good. Sometimes it’s just a fallopian tube or a section of a bowel or just a little chunk of unidentifiable flesh but I love to check them all out. I didn’t know I was so interested in seeing people’s insides. I wear scrubs now and sometimes I feel like an extra on Grey’s Anatomy, haha.

I’m so glad I finally got out of the pharmacy. It feels like I escaped an abusive relationship. I’m happier now than I thought possible. I still miss working at the bike valet sometimes, but I think I actually like my new job even more. There are a few things I don’t like about it, but overall it’s just about as perfect as a job could be for me.

[callmewhenyougetthis-a]

it's about 4 a.m. but i just woke up and wanted to give an update that i am doing fine after surgery! i'm quite sore and exhausted tbh but able to move around and eat. i haven't decided yet if sitting or laying down feels better because getting up from both positions is painful like i just did 1,000 crunches :')

re: replies, not sure when those will come. they'll probably come a bit slowly as i recover (i'm off work for the next 2 weeks, woot)!

thanks everyone for being concerned and supportive throughout this weird ass journey so far in 2023. i know we're all strangers on the internet but like, y'all didn't have to be so nice to me and that makes me emo. <3

more details under the cut - trigger warning cause it's all health related but good news!

so my doctor removed my right ovary and fallopian tube as planned (kinda sad, miss my right ovary, she was a real one) but she told me that my left ovary is in great condition and this whole thing shouldn't affect my fertility, so when hubby and i are ready we can start trying for a little bean. i can't even believe i wrote that sentence because ever since i turned 19 and got diagnosed with pcos i've had this looming cloud over my head that i can't have children. sure this may not be the cure-all and i might still have issues due to pcos, but it's one less road block for us.

more importantly, chances also are that i am 99.9% cancer free because all of the things near my ovary that the cells may have spread to looked unaffected, but she'll give me more results in about a week from now. i am just relieved and hoping for the best!

[mariacallous]

Before a sperm can fertilize an egg, it faces a long journey: Propelled by the back and forth movement of its tail, it needs to swim all the way through the female reproductive tract to the fallopian tube, where it meets an egg. But in a new study, researchers who want to develop on-demand male contraceptives say they’ve figured out a way to prevent pregnancy: temporarily stop the sperm from swimming.

In a paper published today in Nature Communications, the researchers announced that when they injected 52 male mice with an experimental compound called TDI-11861, it temporarily inhibited an enzyme that helps sperm move. When they paired the males off with females to mate, no pregnancies occurred. (The same number of male mice treated with a control substance impregnated almost one-third of their mates.) The effects lasted for up to two and half hours. At around three hours, some sperm started moving again, and by 24 hours, nearly all sperm recovered normal movement. The authors say the results point the way to a short-term birth control option for men.

“It’s pretty clear that this is an on-off switch for sperm,” says Lonny Levin, a professor of pharmacology at Weill Cornell Medicine in New York, and an author on the paper. “We thought inhibiting this would be a great way to stop sperm in their tracks, prevent them from ever leaving the vagina and getting to the promised land to fertilize an egg.” 

But injecting a drug before sex isn’t exactly an appealing idea, so the researchers also tested an oral version in male mice and confirmed that the drug immobilized sperm when delivered this way. This method of birth control doesn’t contain hormones, as pills for women do. The idea is that it could be taken shortly before sex, rather than daily. “I think this is really one of the biggest advancements for non-hormonal contraceptives in recent times,” says Christopher Lindsey, a program official in the National Institute of Child Health and Human Development, which partly funded the work. 

Levin and his collaborator Jochen Buck, also a professor of pharmacology at Weill Cornell, didn’t initially set out to find a male contraceptive. They were studying a regulatory enzyme called soluble adenylyl cyclase, or sAC, which is found in almost every cell. When they genetically engineered mice to lack this enzyme, they found that the males were infertile. The enzyme appears to play a major role in activating a sperm cell’s ability to swim.

That led the researchers on a new quest to develop a potential male contraceptive by designing compounds that could block sAC. But because this enzyme is present elsewhere in the body—and may be necessary for other cellular functions—they didn’t think it would be a good idea to shut it off permanently.

In 2018, Melanie Balbach, a postdoctoral associate in their lab, gave one of those experimental compounds to mice and found that it produced sperm that could not propel themselves forward. “They didn't move. They didn't twitch,” Levin says. But that compound lost its effect once it entered the female reproductive tract. So the researchers kept testing compounds that would keep sperm immobile. 

Over time, they refined TDI-11861. In mice, the drug didn’t appear to interfere with sexual functioning or cause any side effects. And most importantly, the sperm were normal again a day later. 

Of course, there is a big caveat: Mice are not people. But humans also have the sAC enzyme, and in males, it’s also involved in sperm movement. Buck and Levin are reassured that the strategy might be safe in people by another team’s report from 2019, which described two infertile men with mutations in the gene that makes sAC. The men were otherwise healthy, except for having a higher risk of kidney stones. (Mice bred without this gene have elevated eye pressure, which wasn’t a problem found in the men without the gene.) 

To test the safety of their compound, the Cornell team continuously infused it into male and female mice via a pump for six weeks. They noted no side effects, including no kidney issues. They’re now testing the compound in rabbits, which have reproductive organs that are more similar to those of humans. 

Many efforts to create male contraceptives have used hormones—primarily testosterone—to suppress sperm production. But like hormonal birth control for women, these drugs can have an array of negative side effects, including mood swings, weight gain, and decreased libido. Both female and male hormonal birth control also take weeks to become fully effective at preventing pregnancy. A trial sponsored by the National Institutes of Health that’s testing a hormonal gel for men is showing promising results, but the gel must be applied daily to the shoulders to keep sperm levels low enough for effective contraception. 

Some men might prefer a non-hormonal, temporary option. “I think it’s a really wonderful idea and would be very much appreciated by a lot of people who would not maybe want to take a pill every day,” says Gunda Georg, a professor of medicinal chemistry at the University of Minnesota, who researches male and female contraceptives and wasn’t involved in the new work. “I think we need to have many different options for contraception for men and also for women.” 

Georg’s lab developed a non-hormonal pill, dubbed YCT529, that targets a protein called retinoic acid receptor alpha and is involved in sperm formation. In mice, it greatly reduced sperm counts and was 99 percent effective at preventing pregnancy after being given daily for four weeks. 

While Buck and Levin are also working toward a pill, these are less efficient at delivering drugs than injections. The stomach tends to degrade them, and Levin says the current version of their compound would need to be a pretty large pill. The researchers have launched a company, Sacyl Pharmaceuticals, to further refine their sAC inhibitors and advance them to human clinical trials. “We're trying to get a compound that will be a nice, small pill,” Levin says. 

They also acknowledge that the current compound wears off too quickly, which could result in unwanted pregnancies if not taken at exactly the right time, so they’re hoping to extend the window of effectiveness to 18 hours or so. While there’s still a lot of testing ahead, if all goes well, maybe it will play a role in future Valentine’s Days. “Presumably, you could take this over dinner, and then within an hour, similar to Viagra, you would be ready to engage in sexual activity,” Lindsey says. 

[drshivanisachdevgoursciivf]

Demystifying Female Infertility: Exploring 5 Potential Causes

Female infertility is a complex condition that affects a significant number of women around the world. The inability to conceive can be emotionally challenging and often prompts a search for answers. While infertility can have various underlying causes, this article aims to shed light on five potential factors that may contribute to female infertility. By understanding these causes, individuals and healthcare professionals can work together to explore appropriate interventions and treatment options.

Hormonal Imbalances: One of the common causes of female infertility is hormonal imbalances. Hormones such as estrogen, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) play vital roles in regulating the menstrual cycle and promoting ovulation. Any disruption in the delicate balance of these hormones can lead to irregular or absent ovulation, making it difficult for women to conceive.

Structural Abnormalities: Structural abnormalities within the reproductive system can also contribute to female infertility. Conditions such as polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, or blocked fallopian tubes can hinder the fertilization process or implantation of a fertilized egg. These conditions may require medical intervention or surgical procedures to restore fertility.

Age-related Factors: Advancing age is a significant factor that impacts female fertility. As women age, the quantity and quality of their eggs decline. The chances of chromosomal abnormalities and miscarriages increase, making it more challenging to conceive naturally. It is important for women to be aware of their reproductive timeline and seek assistance from healthcare professionals if they face difficulties in conceiving as they get older.

Lifestyle Factors: Certain lifestyle factors can contribute to female infertility. Obesity, excessive alcohol consumption, smoking, drug abuse, and high levels of stress can all have adverse effects on reproductive health. These factors can disrupt hormonal balance, interfere with ovulation, and affect the overall fertility of women. Adopting a healthy lifestyle that includes regular exercise, a balanced diet, and stress management techniques can positively impact fertility.

Medical Conditions and Treatments: Certain medical conditions and treatments can also cause infertility in females. Conditions such as thyroid disorders, autoimmune diseases, diabetes, and cancer can affect fertility. Additionally, treatments such as chemotherapy and radiation therapy can damage the reproductive organs and impair fertility. It is crucial for women with these conditions to consult with their healthcare providers to explore fertility preservation options before undergoing such treatments.

Conclusion: Understanding the potential causes of female infertility is crucial for women and healthcare professionals alike. By identifying these factors, individuals can take proactive steps to address and manage their reproductive health. It is important to remember that each case of infertility is unique, and a comprehensive evaluation by a healthcare professional is essential to determine the underlying cause and develop an appropriate treatment plan. With advancements in medical science and fertility treatments, many individuals can still achieve their dream of starting a family despite facing infertility challenges.

Looking for a Free IVF Consultation with an IVF Specialist? Contact Dr. Shivani Sachdev Gour.

[twotimeracewinnerlandonorris]

Your news about the interview is brilliant, don’t let your brain trick you into being pessimistic! You’ve got so far already. I’ll be keeping all my fingers crossed and wishing on a star for you! You’ll be a great mum :)

thank you thank you thank you! i try to think positive, and i mostly am able to but there's always this nagging in my brain that maybe i can't have kids, and i've thought that so much that i actually think i've made peace with it if that's the case. the thing is though that there's nothing that points to me not being able to have children, it's just how my mind works 🥴

i'm meeting a social worker on november 2nd to check if i'm ok in the head 🤭 and on the same day, i have a hysterosalpingogram scheduled (checking if my fallopian tubes are blocked) cause it would really be a waste of money to buy sperm and get inseminated if i'm blocked down there 🫣

but if everything goes according to plan, i will hopefully be pregnant in a few months 😳

[ivfsurrogacycentreindia]

Test Tube Baby Cost in Mumbai: What to Expect

When couples face challenges in conceiving naturally, assisted reproductive technologies like In Vitro Fertilization (IVF), commonly known as the test tube baby process, offer a beacon of hope. Mumbai, being a hub for advanced medical treatments, is home to numerous fertility clinics providing world-class IVF services. However, one of the most common concerns for couples considering this option is understanding the Test Tube Baby Cost in Mumbai. Let’s delve into the factors that affect the cost and what couples can expect when opting for this treatment in Mumbai.

Understanding Test Tube Baby (IVF) Treatment

Test tube baby treatment, or IVF, involves the fertilization of an egg and sperm outside the body in a laboratory. Once fertilization occurs, the resulting embryo is implanted into the woman’s uterus to initiate pregnancy. This procedure has proven successful for many couples facing infertility due to various reasons, such as blocked fallopian tubes, low sperm count, hormonal imbalances, or unexplained infertility.

Factors Influencing Test Tube Baby Cost in Mumbai

The Test Tube Baby Cost in Mumbai can vary based on several factors. Here’s a closer look at some of the elements that can influence the overall expenses:

Clinic Reputation and Facilities: The cost varies significantly depending on the clinic’s reputation, success rates, and the quality of facilities provided. Reputed clinics with experienced fertility specialists might charge more than smaller or less established centers.

Treatment Protocol: The specific protocol used in IVF treatment can impact the cost. Some patients may require additional medications, hormonal treatments, or advanced techniques like Intracytoplasmic Sperm Injection (ICSI) or Preimplantation Genetic Testing (PGT). These add-ons can increase the overall cost.

Number of IVF Cycles: Success with IVF often requires multiple cycles. If the first attempt does not result in a successful pregnancy, subsequent cycles will incur additional costs, which can impact the total expenditure.

Additional Procedures: Some couples might need extra procedures like sperm or egg donation, embryo freezing, or surrogacy, all of which can contribute to the overall cost of the test tube baby procedure.

Contact Us: +91–8447592299 Email us: info@selectivf.com

Average Test Tube Baby Cost in Mumbai

On average, the Test Tube Baby Cost in Mumbai ranges between INR 1,50,000 to INR 3,00,000 per cycle. This cost typically covers the essential steps of the IVF process, including ovulation induction, egg retrieval, fertilization, and embryo transfer. However, additional procedures and medications may increase this cost.

Why Choose Mumbai for Test Tube Baby Treatment?

Mumbai is one of the leading cities in India for fertility treatments, known for its advanced medical facilities and expert fertility specialists. Patients in Mumbai benefit from access to state-of-the-art technologies, experienced doctors, and personalized care plans tailored to individual needs.

Select IVF has been a trusted name in providing comprehensive fertility services in Mumbai, assisting couples through every step of their IVF journey.

Contact Us: +91–8447592299 Email us: info@selectivf.com

Conclusion

The Test Tube Baby Cost in Mumbai can vary depending on factors such as clinic reputation, treatment protocols, and additional procedures. Despite the costs involved, Mumbai remains a prime location for high-quality fertility treatment, offering hope to countless couples dreaming of starting a family.

For more information or to discuss your fertility treatment options, get in touch with Select IVF. We are here to guide you on your journey toward parenthood.

Contact Us: +91–8447592299 Email us: info@selectivf.com

[themomsandthecity]

IVF vs. IUI: What's the Difference and Which Is Right For You?

In theory, trying to have a baby is simple: you find a partner, have unprotected PIV sex for a few months, and get pregnant. In reality, the process can be a lot more complicated for some people. You might have a same-sex partner, for instance. You or your partner might have a condition that affects your fertility, like polycystic ovary syndrome, or PCOS. Or you might be one of the roughly 12 to 15 percent of couples that experience infertility, defined as not being able to get pregnant after a year of trying. These are all reasons your doctor might mention IVF or IUI. These are both methods of reproductive assistance. In other words, they're meant to make it easier for you or your partner to get pregnant. They do that by placing sperm directly into the uterus (IUI) or by using sperm to fertilize an egg outside the body then inserting that fertilized egg directly into the uterus (IVF). They both have pros and cons, and a doctor can walk you through what makes the most sense for you and your unique situation. But making decisions about reproductive health can be stressful and confusing, so we asked a few experts what you need to know about these two popular options for people trying to conceive. --- Experts Featured in This Article: Jane Frederick, MD, is a reproductive endocrinologist and the medical director at HRC Fertility in Orange County, CA. Adrienne Neithardt, MD, is a reproductive endocrinologist at Boston IVF. Iris Insogna, MD, is a fertility expert at Columbia University Fertility Center. --- What Is IUI? IUI is an acronym for "intrauterine insemination." With this medical procedure, healthy sperm is placed in your uterus as close to the time of ovulation as possible, according to the American College of Obstetricians and Gynecologists (ACOG). Sperm can come from your partner or a donor. Having sperm placed directly in your uterus at or near ovulation (which can be determined through tests such as an ovulation predictor kit, or OPK) already increases the chances of conceiving. But doctors can take additional measures to make conception even more likely. "Many times, I add a medication called Clomid to make sure ovulation will occur," says Jane Frederick, MD, a reproductive endocrinologist and the medical director at HRC Fertility in Orange County, CA. Clomid works by increasing levels of the hormones that make eggs mature, causing ovulation. "It allows me to time the cycle," Dr. Frederick says. With IUI, "it's like having more horses at the gate," Dr. Frederick says. There's also a technique called "sperm washing," where individual, healthy, motile sperms are isolated from the semen before being used for IUI, in the hopes of further increasing the chances of fertilization. What Is IVF? IVF, which stands for "in vitro fertilization," is a little more complicated. It's done in cycles, per ACOG, that can include: * Obtaining an egg. Patients are usually given medication called gonadotropins to trigger ovulation and produce several eggs. Once the eggs are ready, they're removed from the ovaries with a needle. * Fertilization of eggs. The sperm can be added to the eggs in a lab, or a single sperm can be injected into each egg. * Embryo transfer. A few days after fertilization, one or more embryos is placed in the uterus through the vagina. Any healthy embryos that aren't transferred can be frozen and stored for future use. IVF is primarily done for women with infertility caused by damaged or blocked fallopian tubes, severe endometriosis, or other unexplained fertility issues, per ACOG. IUI Pros and Cons IUI is "less involved and less invasive than IVF," says Iris Insogna, MD, a fertility expert at Columbia University Fertility Center. Plus, if you're struggling to conceive, a lot of times your insurance will dictate that you need to try a certain number of cycles of IUI before you can move on to IVF, says Adrienne Neithardt, MD, a reproductive endocrinologist at Boston IVF.… https://www.popsugar.com/family/ivf-vs-iui-48947404?utm_source=dlvr.it&utm_medium=tumblr