#The Fallopian tube get blocked

[reaperexe]

Doc ♡

summary : a gynac visit with your lover and his antics will obviously be fun.

warnings : none just fluff <3

Going to the doc with him was a task in itself. it was just a routine check up but he still insisted in accompanying you.

He seemed to be having a new 'living healthy' mindset recently, being more into vitamins, healthy foods and keeping the body clean and healthy and fussing over you to do so too.

Going as far as cancelling all his plans for the day to be there with you, promptly telling anyone that called to ask about him saying "She needs me today" as you facepalm at his serious expression.

He makes sure you're well fed and stresses on your behalf. Makes sure to ask the important questions as well "the doctor? its a women right?" with the most concerened face ever and you can't tell how hard you tried to not face-palm then and there.

Starts packing hours before the appointment cause "we should be there on time" he says. Drives there early too, the receptionist is staring at both your faces confused as to why you're he's acting as if a normal checkup is a complete crisis.

As he sits at the waiting area he looks around at the various health and informative posters on the wall along with the various models of reproductive system in the room.

He points at the fallopian tube, lighting up as he says "Hey! I know that one, you told me about it" as you smile along like a proud parent.

When you two do enter the doctors office, he sits with his arms folded only because you begged him outside to not pull out his intricate notebook and pen he prepared beforehand, his justification being "but baby I need to note down all the important stuff" with the biggest puppy eyes.

It took all your willpower to still say no to him and you could swear you heard the man whimper before putting the notebook away.

He sits infront of the doctor listening intently to every word she says.

It was surprising to you too how much he knew about you, the questions he asked were also some things you might have forgotten to ask but he remembered perfectly.

Fusses over you after you come home and makes sure all the things that the doctor recommended are implemented, goes as far to research meals that would be healthy for you and your body.

A short one but I needed to get out of the block :,(

[short-honey-badger]

Not all good comes to those who wait

Pairings: Shanks x Female Reader

Warnings: Pregnancy talk and pretty sensitive subjects. Hurt/Comfort and angst. Ectopic pregnancy. You can scroll if this is too much for you.

This is something for me personally to try and get over what's been going on in my life. In the past three months, my relationship almost ended, we got evicted, and as soon as we got moved, I found out I was pregnant at the beginning of October. Last week, I found out it was an ectopic pregnancy, and I've just... not been the same since. But I miss you guys so much, so this is me trying to get past my shitty brain block the best way I know how.

Shanks knows that there is something going on when Trafalgar D. Water Law's face dims in silent sympathy while doing your evaluation. You are only a couple of weeks pregnant, having found out when you couldn't keep any of your food down over a couple of days at the beginning of the month. You had come to him with a bright smile on your beautiful face, hand held protectively over your stomach and the growing bean inside as you quietly told him the good news.

It was unexpected, but not unwelcome. The two of you would hide away in his cabin, whispering sweet words to one another while Shanks held your still-flat belly. He doted on whatever you needed, making sure that you would be comfortable and safe for the duration of your pregnancy. To make sure all went well, he had contacted the Surgeon of Death and asked if Law could come on board and give you a check-up.

With the use of his devil fruit, Law could see that the embryo had not implanted in the correct spot in your womb like it should have been. Instead, it had planted itself in your right fallopian tube. He shucked his latex gloves off and eyed you and the red-haired captain.

You could see the look on his face, and your heart plummets when you catch your lover reaching out to curl his hand around your wrist, squeezing softly as he asks Law what was going on.

Trafalgar clears his throat, tone soft as he locks eyes with you and explains what had happened. Law explains that this is an ectopic pregnancy. That the embryo isn't viable with it having attached to the incorrect part of your body and that the best course of action for your heath would be for him to remove it. He tells you that it is nothing that you have done, that it's simply a freak accident that could happen to anyone. You listen with cotton between your ears, heart shattering, not just for the bean inside you, but for yourself and Shanks.

The excitement you had felt with the check-up plummets into dispare, and you don't realize that you're crying until Shanks slips his hand from your wrist and gently wipes the tears from your cheeks. Law leaves the room to you and your lover, and you stare at him with fearful eyes.

"I don't...was it my fault? What..?"

Shanks immediately pulls you close and into his chest, lips pressed against the crown of your head as he fights back the feeling of tears gathering in his eyes. His own heart is breaking, fear and worry breaking out, and feeling heavy in his chest. He wants to rage and cry at the sea, demand why his amazing darling couldn't have the one thing the two of them had been so excited for. But you don't need that right now. You need him to he strong, so he would be.

"None of its your fault, baby," He whispers furiously and clutches you tighter when you turn to bury your face in his chest, shoulders shaking as sobs begin to overwhelm you. You wrap an arm around your stomach, grief clouding your brain for a child that you would never get the chance to know.

"I've got you, baby. Whatever happens, I'll never let you go," Shanks whispers, and you latch onto his words, eyes clenched shut in pain. You listen to him whisper sweet reassurances and know that slowly, and with time, that you would be okay.

You pull away just enough that Shanks can dip down and seal his lips over your own, his lashes wet with unshed tears. He would make sure that you would pull through. He would be the rock that you needed.

*Ectopic pregnancies are tough, and I hope that this can help someone else know that none of it is your fault. If there is anyone out there that just needs a shoulder to cry on or a kind word, please feel free to message me.*

[russellsppttemplates]

How much of their struggle to have a babies did y/n and Lance's families know? Like, did they keep things more between themselves, or did they share with few people( like y/n mom or Choe)?

Tw: infertility, IVF treatments

"Do you want me to go with you?", Lance wondered, "you wouldn't mind?", you replied, "of course not, sweetheart. We're in this together", he kissed your knuckles, "besides, your mother texted me yesterday saying that she had baked those little cakes I love", he smirked.

"Mom", you called, "remind me again of what happened when aunt and uncle were trying to have a baby", you asked. Having someone in the family with a similar diagnosis to yours meant that the baby questions were somewhat carefully thought through before someone asked them, so asking your mum, you figured, would be safe.

"Oh, well, they tried for a really long time, she took some hormones to help with her ovulation, because she had a low egg count", she said, "at the time, they also saw a specialist but the treatments were not an option for her, but around a year, a year and a half later, your cousin arrived", she finished, "something on your mind?".

"We've been doing the whole calendar thing and ovulation sticks, but it's yet to work", you admitted, "we both have healthy counts, so it's something else, but this really sucks, you know?", you blurted, feeling her hug you to her side, "I'm sorry, darling, but it will all work for the best, I'm sure of it", she kissed your forehead, "besides, it doesn't look like it's a job to try, you know? You have a very handsome looking husband", she smirked as you swatted her hand, "besides, as long as there is love between you two, you'll be good".

.

As much as you didn't feel like shouting out to everyone in the world that you would be undergoing fertility treatments to start building your family, you knew you and Lance needed support. Not because you were ashamed or embarrassed, but it was still a personal matter that involved your families, and having their support would be good to fall back on.

When you arrived at your parents' house, your father was quick to get some drinks out while your mother made some tea and got the little cakes to the coffee table, "so, Lance, everything fine at work?", you dad began, "yes, it's been going really well, actually", he smiled talking about a few new topics and some they had discussed the previous visit you had payed them.

"You're a bit quiet, darling, is everything okay?", your mother noticed, rubbing your thigh from her seat by your side, "Actually, I've been meaning to tell you something, we have, actually", you gulped, "We have been to Dr. Marlin's office again because we've been having trouble with trying for a baby, and as it turns out, it's a blocked fallopian tube, so things aren't ending up where they should end up and it makes the whole thing pretty much impossible this way",

"Oh, Y/N, I'm sorry", she got up to hug you before your dad gestured the sign you've had since you were little. You sometimes got scared when going to school, so whenever you were already inside the gate and he couldn't give you another hug after dropping you off, he would slightly cross his arms on his chest as if he was hugging you and you would do the same before stretching out your pointer finger as he did the same, pretending you were touching his. It had become a silly thing when you were little, but it quickly became your thing.

"We are going to begin the treatments soon, hopefully", Lance took over, "Dr. Marlin just needs to get the cycle up to speed and sorted out, and then we begin them when Y/N is comfortable enough", Lance noted, absentmindedly grabbed your hand in his, his thumb rubbing the skin.

"Honey, if there is anything we can help you, help you both", your father said, "let us know. You're not going through this alone", he smiled.

.

"How are you doing with all of it?", Chloe asked her younger brother as she bounced her little one in her arms. Scotty and Chloe had finally felt okay enough to welcome visitors to meet the new addition to the Stroll-James family and you and Lance also found the time to vist them between both of your schedules.

"I've been good. I think now that we know what is happening, we know how to deal with it. We kept trying and it wasn't working, so to know why it wasn't working and that there is a way to help it's comforting", he admitted, "Y/N has been good, too, I think. I've made sure she's telling me how she feels and whenever things get too much so we can work it out together, like a team", he smiled, stretching his arm and softly touching his nephew's cheek.

"I was so scared to invite you because I didn't want Y/N to feel bad about it. I know it's stupid to try and put myself in her position when I've never had issues, but I didn't want either of you feeling bad", Chloe added, "thanks for your consideration, but I think it's fine", Lance smiled as he heard Scotty's footsteps and your giggles coming their way.

"I'm proud of you, Lance", his sister complimented, "of the man you've become. I'm not saying I doubted you'd be like this, but it's a pleasure to see you like this", she nudged him, seeing her husband and you walking into the living room.

"Hey, look who's up!", you cooed at the little bow, "can Auntie Y/N have a cuddle? It's okay if it's not, though", you checked with your sister in-law, "of course it's okay, it gives me time to go to the bathroom!", she cheered, passing her son to your arms, "hello, sweet boy, you're wide awake now, aren't you?", you smiled, touching his soft cheek and seeing his light coloured eyes now open, "here", you heard Lance call you, arranging the space next to him on the sofa so you could sit next to him, wrapping his arm around your shoulders, "are you feeling good?", he wondered, checking in as you smiled at him, "yes, I am. Thank you for checking in", you kissed his cheek, "and this is good practice, isn't it? Isn't it, gorgeous boy? Yes, it is", you cooed at your nephew, hoping that this was a practice moment for what was to come.

(Thank you for submitting an ask 🤍)

[figmentforms-the-human]

I’m finally starting my first round of IVF injections for egg retrieval and I can’t help but feel like my ruined fallopian tubes are the blocked Suez Canal and my eggs are the shipping boats traveling around an entire continent just to get to what WOULD HAVE been a very close destination if not for a random bullshit occurrence.

I should have named my tumor the Ever Given

[affectionatepanda]

I recently had a diagnostic laparoscopy because my doctor and I were sure I had endometriosis. None was found (although I’m not entirely convinced it’s not the problem but I’m no expert) but what was found was just… So much scar tissue. Things were stuck to other things and I had an organ twisted out of place. The biggest thing for my long term health (I think) that was found- and this might be TMI but really is anyone going to read this?- my fallopian tubes are completely blocked. Meaning I can’t have children unless I either get that treated or use IVF. I didn’t particularly want to have children, at least not by using my body. But it’s weird knowing that it’s not even really an option for me. I’m not sure I’ve really processed this information; I just feel numb about it. Apparently blocked fallopian tubes are a fairly common cause of infertility. Infertility. Is that something I have to identify with now? Do I have to say I’m infertile? I’m really adding to my list of adjectives over here. Chronically ill, disabled, mentally ill, lesbian, nonbinary, neurodivergent… infertile? I guess I am. It’s such a strange feeling. I don’t know what to do with it. Oh, and we don’t know exactly what caused the scarring. My doctor’s best guess was some sort of infection but I don’t remember ever having any kind of infection that would cause this. I thought this would give me answers but I feel just as confused as before. But I’ve deemed “fixed” and he said I only need to be seen for routine screenings anyone my age would get. Maybe I’m supposed to be satisfied with that. Maybe I want too much out of my doctors, I don’t know. All I know is I don’t really… have anyone to talk to about this. Not anyone who knows what to say. It’s fine though, I don’t even know what I want to hear.

[eggtartz]

I think I accidentally sent my request for you to another account thinking it was yours a few days ago🥲 but just in case i did it was supposed to be a shinichiro x fem reader. Where shin and reader are married and have been trying for a baby but haven’t had any success so they end up going to the doctors where they find out that reader can’t have kids. It makes her depressed because she believes that since shin is a big family type of guy that he will leave her. Shin starts to notice how distanced she’s been and comforts her and assures her that he won’t leave her.

a/n : love, live, laugh with angst uh i love writing angst, i suddenly become divorced mother with two kids anyways thankyou for requesting anon 🫶🏻

masterlist

you have married shinichiro for two years now. after discussing and suggestions and of course teases, the two of you finally settled down to have children of your own. so shin did everything he possibly can to candle night dinner to vacations to renting a love motel so you two can work on having a kid.

however it's been almost a year of trying to have a baby, you've grown concerned if having a baby is possible for you. so while shin went to work, you went to the nearest clinic to have a checkup.

what the results that the doctor gave you was heart shattering.

"so ms sano, unfortunately you are infertility. if you could see the results here your dallopian tube obstruction is the problem. if it's blocked or scarred, fallopian tubes can prevent sperm from reaching the egg" the doctor explain to you while you're two seconds from crying.

"meaning doctor?" you shakingly asked.

"it means ma'am that your husband sperm won't be able swim to it's supposed direction because it's blocked. that also mean you cannot get pregnant" you already was at the verge of tears and you started crying there. you sobbed uncontrollably at the chair while the doctor went to rub your back. "there's adoptions if you want ma'am. don't be too sad"

sure adoption was available but it doesn't feel the same, the child isn't your blood and flesh. you were always excited to feel those day where the baby would kick your stomach or you would lay at the hospital pushing the baby out. it's different, everything's different.

moreover, shin wanted a big family. god knows what shin's gonna say since he always wanted a big family. is he gonna leave you for someone fertile? for someone who can give him a big family like he always wanted?

you left the clinic with your mind clouded, heart heavy. you kept thinking that shin would surely leave you, you figured you can't tell the news to your husband now. you went home, cook dinner as usual and everything as usual.

when your husband came home, you weren't there to greet him like usual so he thought you feel asleep or was too tired. he saw you cooped up in the bed, reading a book about pregnancy.

"hey babe.. how's your day?"

"fine"

"hm? you tired?"

"a little bit. you wanna eat something? i can reheat dinner" you forced your body to move from the bed but you husband pushed you back gently. "no need sweetheart, i already ate. how about i go shower and we cuddle yeah?" you nodded at his suggestion, shin getting confused at your reaction. shin noticed how your responses are short and lack emotions. shin noticed how your body is stiff and tense. shin notices how your face doesn't brighten up at the idea of desserts again.

what was it? what happened?

he took a cold shower to clear up his head. you have behaved like this for three days now and your husband has had enough. shin didn't wanted you two to drift away just because you can't communicate. shin wrapped a towel around his waist and another towel drying his hair. he was about to take his hoodie out until a paper fell.

what?

"y/n l/n. explain this" shin threw the paper right in front of you who was watching tv. you were horrified when you recognized where the paper belonged and what it contains. it's now or never.

"i- i went for a checkup.. and this.. is the result" your voice sliced through the silence of the night, it was slow but audible enough. "i.. i can't get pregnant shin.. i- i can't.." you continued, struggling to not pathetically cry. shin kneeled down and touched your face to look at him. "was this reason you're distancing yourself from me?"

"yes! i- i know you wanted a big family and.. and i can't even give you a child like anyone else! you'll.. you'll leave me but.. but i can't lose you.. i can't.." you hysterically sobbed now the emotions you kept away was flowing, not showing any signs it'd stop.

"y/n. look at me" you finally looked at his face thriughy blurry eyes.

"i love you. and i would never do that. it's okay if we can't have a big family, not everything needs to be done. i would never leave you just because you can't get pregnant. i love you y/n, no matter what" your husband soothing voice reached you that made your sobbing even worse. shin reached your face and kissed your lips, muffling your cries.

"im sorry.. i should've-"

"it's okay baby, it's just.. don't keep everything to yourself okay? im your husband, we can talk you know? don't do that again yeah?" your husband asked while you nodded again, still crying. your sobs went down after a while and shin lifted your body to your shared bedroom.

you hugged him tighter that night and he held you closer, none of you willing to let go.

[avesblues2]

Update after procedure.

Finally feeling better, just enough, to type an update. I'm sensitive to anesthesia so it makes me pretty nauseous! I'm still super tired and will nap after this text lol!

The procedure was about two hours. I didn't get to hear the results because I was knocked out but the doctor contacted my husband and gave him an overview, which i can call to get more details or what to my post op.

He said it was a very bad case of endometriosis. I was/am diagnosed with SEVERE stage 4 endometriosis. However, he was able to remove all of it.

The cyst in my ovary was huge but he removed it from the root and my ovary is still there! No cysts on the other ovary.

I had severe scar tissue along my whole uterus and in other places. Along with adhesions EVERYWHERE. My Fallopian tubes were also blocked because of this but he cleared them without hurting the tubes in anyway! So my tubes are now cleared.

He was able to get everything completely out.

However, this information I will find out at post op is when we can start trying! Because it was so severe, he does want to a wait a little bit but not sure what that timeline is! he wants me to take it easy for the next weeks because of the severity and just relax and I should stop feeling nauseous by tomorrow as well.

The Lord has answered my prayers

-the staff was so incredible, the most loving and kind and supportive hospital staff I've ever countered (I've had three other surgeries lol)

-The lord allowed me to keep my tubes and ovaries!

-my tubes are cleared

-the endo is gone!

Downside, endometriosis does come back however we will be going over different methods and medications to minimize it.

Finally, he is EXTREMELY optimistic I can now get pregnant with ease!

Thank you for your prayers. All the love and support I got brings me to tears, even right now. I'm so overwhelmed with peace and joy and feel so so loved. Thank you thank you

[eversailedinafirefly]

hey there uterus-burdened folks, i’m in need of some advice??

went in to my gyno for a pretty standard IUD replacement and because I was having some v unpleasant cyst symptoms (not entirely abnormal) i asked him to poke around up there with his ultrasound a lil longer. turns out, ya girl has a blocked fallopian tube and is getting fast-tracked to an endo diagnosis and a potential laparoscopy

except not that fast, bc it’s the Netherlands and healthcare is cheap and pretty good but decidedly not fast. and in the mean time I’m just in more and more pain (especially in the mornings) and my stomach is all out of whack and bloated and eating is harder than I’d like it to be. plus like, the crushing mental realization that something about my body is fundamentally wrong again*, the girl who fuckin hates medical procedures now gets another metric shit ton on my plate, and this shit will have a decided impact on the future i’m trying to build with a beloved partner. ya know, little things.

so anyway, if anyone has any advice on just short term pain and symptom management for this, it would be really helpful. I’m just tired of dealing with my body and if anyone can make me hate it less rn I’d appreciate it ❤️

*ya girl ALSO has MS because if there is a god they decided to fuck my life in particular

[portlandvalentine]

Oh hi, if anyone’s still reading. I worked at the pharmacy for 11 miserable months, but was finally able to transfer to a new job at the hospital. There was a whole thing where my boss at the pharmacy actually tried to block my transfer, claiming that if I left it would harm patients, because everyone else would be more busy and a pharmacist might make a mistake and kill someone and that would be on me! I was a fucking pharmacy cashier! I mean that job title doesn’t really convey my MANY duties at the pharmacy; it was more like I was running the front end of the pharmacy, distributing medications, being the first and only human most patients dealt with directly/being the punching bag for hundreds of patients every day, etc. And it’s true that me leaving created more work for others, but guess what, that’s not my fucking problem!

I had to get the union involved and eventually I was able to start my new job. I’ve been there almost three months now and it is pretty much awesome! I mean, as far as jobs go. I work as a hospital transporter now. Basically I move medical equipment, blood, specimens, etc around the hospital. I don’t have to deal with patients! Most of my coworkers primarily move patients and they (potentially) make a little more money for it, but after the pharmacy I don’t ever want to deal with patients again. I work alone and I’m walking around pretty much nonstop all day. I walk 10-13 miles a day and I love it. I’m often moving heavy ass hospital beds long distances and I feel like I’m getting so strong. I go to basically every single part of the huge hospital campus. It’s routine enough to be comfortable, but at the same time varied enough to keep things interesting. An app assigns me a job, I do the job, then the app assigns me my next job. There’s no balancing 13 different urgent tasks at a time like at the pharmacy while also being yelled at by patients. Occasionally I get to transport an entire organ or a severed limb! Those are my favorite jobs: if the app is sending me to pick up a specimen in the OR I know it’s gonna be good. Sometimes it’s just a fallopian tube or a section of a bowel or just a little chunk of unidentifiable flesh but I love to check them all out. I didn’t know I was so interested in seeing people’s insides. I wear scrubs now and sometimes I feel like an extra on Grey’s Anatomy, haha.

I’m so glad I finally got out of the pharmacy. It feels like I escaped an abusive relationship. I’m happier now than I thought possible. I still miss working at the bike valet sometimes, but I think I actually like my new job even more. There are a few things I don’t like about it, but overall it’s just about as perfect as a job could be for me.

[callmewhenyougetthis-a]

it's about 4 a.m. but i just woke up and wanted to give an update that i am doing fine after surgery! i'm quite sore and exhausted tbh but able to move around and eat. i haven't decided yet if sitting or laying down feels better because getting up from both positions is painful like i just did 1,000 crunches :')

re: replies, not sure when those will come. they'll probably come a bit slowly as i recover (i'm off work for the next 2 weeks, woot)!

thanks everyone for being concerned and supportive throughout this weird ass journey so far in 2023. i know we're all strangers on the internet but like, y'all didn't have to be so nice to me and that makes me emo. <3

more details under the cut - trigger warning cause it's all health related but good news!

so my doctor removed my right ovary and fallopian tube as planned (kinda sad, miss my right ovary, she was a real one) but she told me that my left ovary is in great condition and this whole thing shouldn't affect my fertility, so when hubby and i are ready we can start trying for a little bean. i can't even believe i wrote that sentence because ever since i turned 19 and got diagnosed with pcos i've had this looming cloud over my head that i can't have children. sure this may not be the cure-all and i might still have issues due to pcos, but it's one less road block for us.

more importantly, chances also are that i am 99.9% cancer free because all of the things near my ovary that the cells may have spread to looked unaffected, but she'll give me more results in about a week from now. i am just relieved and hoping for the best!

[mariacallous]

Before a sperm can fertilize an egg, it faces a long journey: Propelled by the back and forth movement of its tail, it needs to swim all the way through the female reproductive tract to the fallopian tube, where it meets an egg. But in a new study, researchers who want to develop on-demand male contraceptives say they’ve figured out a way to prevent pregnancy: temporarily stop the sperm from swimming.

In a paper published today in Nature Communications, the researchers announced that when they injected 52 male mice with an experimental compound called TDI-11861, it temporarily inhibited an enzyme that helps sperm move. When they paired the males off with females to mate, no pregnancies occurred. (The same number of male mice treated with a control substance impregnated almost one-third of their mates.) The effects lasted for up to two and half hours. At around three hours, some sperm started moving again, and by 24 hours, nearly all sperm recovered normal movement. The authors say the results point the way to a short-term birth control option for men.

“It’s pretty clear that this is an on-off switch for sperm,” says Lonny Levin, a professor of pharmacology at Weill Cornell Medicine in New York, and an author on the paper. “We thought inhibiting this would be a great way to stop sperm in their tracks, prevent them from ever leaving the vagina and getting to the promised land to fertilize an egg.” 

But injecting a drug before sex isn’t exactly an appealing idea, so the researchers also tested an oral version in male mice and confirmed that the drug immobilized sperm when delivered this way. This method of birth control doesn’t contain hormones, as pills for women do. The idea is that it could be taken shortly before sex, rather than daily. “I think this is really one of the biggest advancements for non-hormonal contraceptives in recent times,” says Christopher Lindsey, a program official in the National Institute of Child Health and Human Development, which partly funded the work. 

Levin and his collaborator Jochen Buck, also a professor of pharmacology at Weill Cornell, didn’t initially set out to find a male contraceptive. They were studying a regulatory enzyme called soluble adenylyl cyclase, or sAC, which is found in almost every cell. When they genetically engineered mice to lack this enzyme, they found that the males were infertile. The enzyme appears to play a major role in activating a sperm cell’s ability to swim.

That led the researchers on a new quest to develop a potential male contraceptive by designing compounds that could block sAC. But because this enzyme is present elsewhere in the body—and may be necessary for other cellular functions—they didn’t think it would be a good idea to shut it off permanently.

In 2018, Melanie Balbach, a postdoctoral associate in their lab, gave one of those experimental compounds to mice and found that it produced sperm that could not propel themselves forward. “They didn't move. They didn't twitch,” Levin says. But that compound lost its effect once it entered the female reproductive tract. So the researchers kept testing compounds that would keep sperm immobile. 

Over time, they refined TDI-11861. In mice, the drug didn’t appear to interfere with sexual functioning or cause any side effects. And most importantly, the sperm were normal again a day later. 

Of course, there is a big caveat: Mice are not people. But humans also have the sAC enzyme, and in males, it’s also involved in sperm movement. Buck and Levin are reassured that the strategy might be safe in people by another team’s report from 2019, which described two infertile men with mutations in the gene that makes sAC. The men were otherwise healthy, except for having a higher risk of kidney stones. (Mice bred without this gene have elevated eye pressure, which wasn’t a problem found in the men without the gene.) 

To test the safety of their compound, the Cornell team continuously infused it into male and female mice via a pump for six weeks. They noted no side effects, including no kidney issues. They’re now testing the compound in rabbits, which have reproductive organs that are more similar to those of humans. 

Many efforts to create male contraceptives have used hormones—primarily testosterone—to suppress sperm production. But like hormonal birth control for women, these drugs can have an array of negative side effects, including mood swings, weight gain, and decreased libido. Both female and male hormonal birth control also take weeks to become fully effective at preventing pregnancy. A trial sponsored by the National Institutes of Health that’s testing a hormonal gel for men is showing promising results, but the gel must be applied daily to the shoulders to keep sperm levels low enough for effective contraception. 

Some men might prefer a non-hormonal, temporary option. “I think it’s a really wonderful idea and would be very much appreciated by a lot of people who would not maybe want to take a pill every day,” says Gunda Georg, a professor of medicinal chemistry at the University of Minnesota, who researches male and female contraceptives and wasn’t involved in the new work. “I think we need to have many different options for contraception for men and also for women.” 

Georg’s lab developed a non-hormonal pill, dubbed YCT529, that targets a protein called retinoic acid receptor alpha and is involved in sperm formation. In mice, it greatly reduced sperm counts and was 99 percent effective at preventing pregnancy after being given daily for four weeks. 

While Buck and Levin are also working toward a pill, these are less efficient at delivering drugs than injections. The stomach tends to degrade them, and Levin says the current version of their compound would need to be a pretty large pill. The researchers have launched a company, Sacyl Pharmaceuticals, to further refine their sAC inhibitors and advance them to human clinical trials. “We're trying to get a compound that will be a nice, small pill,” Levin says. 

They also acknowledge that the current compound wears off too quickly, which could result in unwanted pregnancies if not taken at exactly the right time, so they’re hoping to extend the window of effectiveness to 18 hours or so. While there’s still a lot of testing ahead, if all goes well, maybe it will play a role in future Valentine’s Days. “Presumably, you could take this over dinner, and then within an hour, similar to Viagra, you would be ready to engage in sexual activity,” Lindsey says. 

[drshivanisachdevgoursciivf]

Demystifying Female Infertility: Exploring 5 Potential Causes

Female infertility is a complex condition that affects a significant number of women around the world. The inability to conceive can be emotionally challenging and often prompts a search for answers. While infertility can have various underlying causes, this article aims to shed light on five potential factors that may contribute to female infertility. By understanding these causes, individuals and healthcare professionals can work together to explore appropriate interventions and treatment options.

Hormonal Imbalances: One of the common causes of female infertility is hormonal imbalances. Hormones such as estrogen, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) play vital roles in regulating the menstrual cycle and promoting ovulation. Any disruption in the delicate balance of these hormones can lead to irregular or absent ovulation, making it difficult for women to conceive.

Structural Abnormalities: Structural abnormalities within the reproductive system can also contribute to female infertility. Conditions such as polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, or blocked fallopian tubes can hinder the fertilization process or implantation of a fertilized egg. These conditions may require medical intervention or surgical procedures to restore fertility.

Age-related Factors: Advancing age is a significant factor that impacts female fertility. As women age, the quantity and quality of their eggs decline. The chances of chromosomal abnormalities and miscarriages increase, making it more challenging to conceive naturally. It is important for women to be aware of their reproductive timeline and seek assistance from healthcare professionals if they face difficulties in conceiving as they get older.

Lifestyle Factors: Certain lifestyle factors can contribute to female infertility. Obesity, excessive alcohol consumption, smoking, drug abuse, and high levels of stress can all have adverse effects on reproductive health. These factors can disrupt hormonal balance, interfere with ovulation, and affect the overall fertility of women. Adopting a healthy lifestyle that includes regular exercise, a balanced diet, and stress management techniques can positively impact fertility.

Medical Conditions and Treatments: Certain medical conditions and treatments can also cause infertility in females. Conditions such as thyroid disorders, autoimmune diseases, diabetes, and cancer can affect fertility. Additionally, treatments such as chemotherapy and radiation therapy can damage the reproductive organs and impair fertility. It is crucial for women with these conditions to consult with their healthcare providers to explore fertility preservation options before undergoing such treatments.

Conclusion: Understanding the potential causes of female infertility is crucial for women and healthcare professionals alike. By identifying these factors, individuals can take proactive steps to address and manage their reproductive health. It is important to remember that each case of infertility is unique, and a comprehensive evaluation by a healthcare professional is essential to determine the underlying cause and develop an appropriate treatment plan. With advancements in medical science and fertility treatments, many individuals can still achieve their dream of starting a family despite facing infertility challenges.

Looking for a Free IVF Consultation with an IVF Specialist? Contact Dr. Shivani Sachdev Gour.

[fertilityccentrenepal]

How do experts perform IVF treatment in Nepal that blesses couples with their children?

IVF treatment in Nepal is a simple fertility procedure that consists of six steps, and these are:

1. Stimulation: During stimulation, a specialist gives a woman fertility drugs to increase the number of mature and healthy eggs in one cycle. When performing stimulation, a fertility specialist examines a woman's ovaries using ultrasound and blood tests to check hormone levels.

2. Egg retrieval: In this step of IVF in Nepal, the specialist gives the woman medication to help ease her discomfort. The specialist performs local anaesthesia, and the ovarian follicles are aspirated with a needle guided by transvaginal ultrasonography. An experienced embryologist scans a woman's follicular fluids to find available eggs in her ovaries. Then these eggs are placed in a unique medium and cultured in an incubator until insemination.

3. Fertilization and Insemination: It is the step of IVF in Nepal, where the male member's sperm is placed together with the female's eggs. The joining of sperm and egg is known as insemination, and fertilization occurs after 16 to 18 hours of insemination.

4. Embryo Cultivation: It is a step of IVF Nepal where the specialist regularly checks that the embryo's growth is done correctly. Within five days, a normal embryo has several cells that are actively dividing. The entire procedure gets performed after 3 to 4 days of fertilization. A couple can opt for PGD to help them decide which embryo to implant and reduce the chance of passing the disorder on to the child.

5. Embryo transfer: During embryo transfer, the fertilized embryo will get implanted into the woman's uterus 3 to 5 days after egg retrieval and fertilization. The specialist will insert a thin tube that contains the embryo into the woman's vagina, through the cervix and up into the uterus. If the embryo gets adequately placed in the lining of the woman's womb, it grows and a pregnancy results.

6. Pregnancy test: After two weeks of embryo transfer, the couple must take a pregnancy test performed by a specialist using ultrasound. They scan the woman's ovaries to hear the baby's heartbeat, and once they can hear, it means the pregnancy is confirmed. The patient can be discharged from the fertility clinic to the local gynaecologist.

What conditions can be treated with IVF treatment in Nepal?

Below are the conditions that can be treated with IVF treatment in Nepal. These are:

1. Blocked or Damaged Fallopian Tubes: Women dealing with blocked or damaged fallopian tubes can have a baby with IVF in Nepal.

2. Problems with ovulation: If women have problems with ovulation, then fertility experts recommend drugs like Metformin and Clomiphene during IVF treatment. Metformin is recommended for women with polycystic ovary syndrome (PCOS), and Clomiphene is given to infertile women to help stimulate the ovaries. They can produce enough eggs for fertilization.

3. Unexplained Infertility: Unexplained infertility is a problem where fertility experts have been unable to find the root cause after a medical examination; in such cases, the fertility specialist gives women drugs such as Clomiphene, hormone injections and insemination.

4. Male Infertility Problems: If the male partner cannot produce enough sperm for fertilization, in such cases, experts surgically extract the sperm from the male ejaculate and fertilize it with a female egg to facilitate fertilization.

5. Decline in Ovarian Reserve: Women above 35 face problems with ovarian reserve as there is a decline in the stars. For these women, IVF in Nepal is the best option to increase the chances of conceiving at an increasing age.

How successful is IVF in Nepal?

IVF Nepal success rate is around 60-70% for women under 35, which is relatively high compared to other infertility clinics in Nepal. However, the success rate depends on the couple's age, causes of infertility, previous medical history, etc. The clinic's success rate is high because fertility experts use the latest and advanced technology to treat infertility problems and give their best to achieve a successful result in one fresh IVF cycle without any complications for the mother and child.

[drrupali]

Difficulty in Getting Pregnant: 10 Reasons for infertility

Infertility can be a heartbreaking and frustrating journey for couples trying to conceive. While the desire to have a child is universal, the path to pregnancy is not always as easy as expected. If you've been trying for months or even years with little success, you're not alone. Understanding the common causes of infertility can help you navigate this challenging time. Whether you're dealing with female or male infertility, discovering the underlying reasons is a crucial step toward finding the right treatment and improving your chances of conception.

In this article, we will explore 10 potential reasons for infertility, highlighting both medical and lifestyle factors that could be affecting your ability to get pregnant. Additionally, we'll discuss how seeking advice from the best IVF specialist doctor in Delhi or top IVF doctors in Delhi may help you achieve your dream of becoming a parent.

Ovulation Disorders Ovulation is the process where an egg is released from the ovaries. If ovulation is irregular or doesn't occur, conception becomes very difficult. Common ovulation disorders include conditions like Polycystic Ovary Syndrome (PCOS) or hypothalamic dysfunction. These conditions can cause hormonal imbalances, preventing the release of an egg.

If you're struggling with irregular periods or have a history of ovulation issues, consulting a top IVF doctor in Delhi can help identify the problem and explore treatment options such as ovulation-inducing medications or IVF.

Blocked Fallopian Tubes The fallopian tubes are essential for transporting eggs from the ovaries to the uterus. If these tubes are blocked or damaged, sperm may not be able to reach the egg, making conception nearly impossible. Tubal blockage is often caused by pelvic inflammatory disease (PID), endometriosis, or previous surgeries.

If you suspect a problem with your fallopian tubes, an IVF treatment cycle could be an effective option, and the best IVF specialist doctor in Delhi can help assess the condition and guide you toward the right course of action.

Male Infertility Issues While female infertility often takes center stage, male infertility is just as common. Male infertility can result from low sperm count, poor sperm motility, or abnormal sperm shape. Lifestyle factors, such as smoking, excessive alcohol consumption, or obesity, can also contribute to infertility in men.

If you or your partner are experiencing infertility, it's important to address male fertility concerns as well. Seeking guidance from a top IVF doctor in Delhi can help diagnose the problem and explore solutions such as sperm retrieval or intrauterine insemination (IUI).

Endometriosis Endometriosis is a painful condition where tissue similar to the lining of the uterus grows outside of it. This condition can cause scar tissue, adhesions, and inflammation, which may block the fallopian tubes or interfere with egg implantation. Women with endometriosis often face difficulty getting pregnant, but with the right treatment plan, successful pregnancy is possible.

An experienced IVF specialist doctor in Delhi can offer advanced fertility treatments to improve your chances of conception if you have endometriosis.

Polycystic Ovary Syndrome (PCOS). PCOS is one of the most common causes of infertility in women. This hormonal disorder causes the ovaries to develop small cysts, which can disrupt the normal production of eggs. Women with PCOS often have irregular periods, making ovulation unpredictable.

Treatment for PCOS may include lifestyle changes, medications, and IVF, depending on the severity of the condition. Consulting a top IVF doctor in Delhi can help you navigate your treatment options effectively.

Unexplained Infertility. Sometimes, despite extensive testing, doctors can not pinpoint the cause of infertility. This is known as unexplained infertility, and it can be incredibly frustrating for couples. In many cases, unexplained infertility may resolve with time, but in others, IVF or other assisted reproductive technologies can increase the chances of conception.

If you're facing unexplained infertility, don't lose hope. Visiting the best IVF specialist doctor in Delhi can provide clarity on your next steps and offer advanced treatments to optimize your fertility.

Lifestyle Factors. Your lifestyle choices can significantly impact your ability to get pregnant. Smoking, drinking alcohol, and an unhealthy diet can all contribute to infertility. Being overweight or underweight can also affect hormone production and fertility.

Maintaining a healthy lifestyle, managing your weight, and reducing exposure to harmful substances can boost your fertility and improve the chances of conception.

Stress and Mental Health. Emotional well-being plays a significant role in fertility. Chronic stress can disrupt the hormonal balance necessary for ovulation and sperm production. Additionally, emotional factors such as depression and anxiety can affect the desire to conceive or hinder the process of fertility treatments.

It's crucial to manage stress through relaxation techniques, therapy, and support groups. This will not only improve your mental health but can also increase the likelihood of conception.

Environmental Factors. Exposure to environmental toxins, such as pesticides, heavy metals, and chemicals, can affect fertility in both men and women. These toxins can interfere with hormone production, reduce sperm quality, and increase the risk of birth defects.

If you're concerned about environmental factors affecting your fertility, it's worth consulting with a top IVF doctor in Delhi who can advise on how to limit exposure to harmful substances.

Seeking the Best IVF Specialist Doctor in Delhi. When faced with infertility, seeking professional help is crucial. Finding the best IVF specialist doctor in Delhi can provide you with the expertise, care, and treatment options that may be necessary to overcome infertility. IVF doctors in Delhi offer cutting-edge treatments, personalized care, and a track record of successful pregnancies.

The right IVF doctor will listen to your concerns, perform necessary tests, and create a tailored treatment plan to help you conceive.

Top IVF Doctors in Delhi: What to Look For. When choosing an IVF specialist, it's essential to find a doctor who is experienced, compassionate, and offers state-of-the-art treatment. Look for doctors with advanced certifications, a strong reputation in the fertility community, and a track record of success.

The top IVF doctors in Delhi are known for their expertise, success rates, and personalized care. Make sure to research and consult with doctors who offer a range of fertility treatments and are dedicated to helping you achieve your dream of parenthood.

When to Seek Fertility Treatment. It's important to seek fertility treatment when you have been trying to conceive for a year (or six months if you're over 35) without success. Early intervention can improve the chances of a successful pregnancy and prevent further delays.

Visiting a top IVF doctor in Delhi early on can help identify any potential issues and give you a better chance of achieving a healthy pregnancy.

How IVF Can Help Overcome Infertility. IVF is one of the most effective treatments for infertility. It involves the fertilization of an egg outside the body, followed by implantation into the uterus. IVF is especially useful for women with blocked fallopian tubes, ovulation disorders, or male infertility.

By consulting the best IVF specialist doctor in Delhi, you can learn about the different IVF techniques and decide whether it's the right treatment for your situation.

Conclusion. While infertility can be a challenging and emotional journey, understanding the causes and knowing when to seek help can increase your chances of success. Whether it's a medical condition, lifestyle factor, or unexplained infertility, many treatment options can help. Consulting with the best IVF specialist doctor in Delhi or top IVF doctors in Delhi can provide you with the guidance and support you need.

FAQs.

What are the main causes of infertility? The main causes include ovulation disorders, blocked fallopian tubes, male infertility, endometriosis, and PCOS. Sometimes, no specific cause can be found, which is known as unexplained infertility.

How can IVF help if I have infertility? IVF can help by fertilizing eggs outside the body and implanting them into the uterus. It's effective for overcoming several infertility issues such as blocked fallopian tubes, low sperm count, and hormonal imbalances.

At what age should I consult an IVF specialist? It's recommended to consult an IVF specialist if you've been trying to conceive for over a year without success. For women over 35, seeking help sooner (around six months) may increase your chances of success.

How can stress impact fertility? Chronic stress can affect hormonal balance, making it harder to conceive. Stress can interfere with ovulation and sperm production, and managing it through relaxation techniques can improve fertility.

What should I look for in an IVF specialist? When choosing an IVF specialist, look for experience, positive patient reviews, high success rates, and a compassionate approach to care. It's important to feel comfortable with the doctor and trust their expertise.

[drvinayakdas12]

Understanding The Common And Silent Signs Of Uterine Fibroids

Uterine fibroids are non-cancerous growths that usually develop among women during the childbearing years. These fibroids develop when a single cell in the uterine lining divides uncontrollably and leads to a rubbery mass in the uterus. Although these fibroids are malignant and don’t spread to any other region, they still can increase your risk of developing uterine cancer. If your ultrasound has also showcased the presence of uterine fibroids then it is vital for you to contact the best gynecologist in Siliguri for proper treatments.

Uterine fibroids can be associated with various distressing symptoms and health complications. However, in some cases, the signs of this gynecological condition can be silent. If the fibroids are small then it doesn’t affect the quality of life among women as it causes no symptoms. You must know that the signs of this condition depend upon the location, number, and size inside the uterus. It is important for you to learn about the silent symptoms so that you can get timely intervention and minimize the risks of severe complications.

H2- Silent Symptoms Of Fibroids You Should Know About

Pelvic Pain

If you’re suffering from recurrent pelvic pain then you must not ignore it as it can be a sign of large fibroids. In most cases, this pelvic pain feels like a vague discomfort with sudden sharp pains that cause pressure and heaviness in the lower abdomen. Sometimes, you may experience this discomfort when you exercise, lie face down, or bend over.

Heavy menstrual bleeding

We often think of heavy menstruation as a normal problem, as it can happen due to hormonal imbalances. However, you need to be careful about this sign since it can also indicate uterine fibroids. When you have fibroids, your uterus cannot contract normally, which is considered the main reason behind heavy menstruation. If you are experiencing menstrual issues for a longer period, you must visit the best gynecologist hospital in Siliguri.

Constipation

Fibroids can also cause constipation. In some cases, uterine fibroids can grow near the intestines and bladder, putting external pressure on the bowel, and causing constipation. If the larger fibroids are left untreated, they can completely block the intestines while causing permanent damage to the digestive tract, leading to severe abdominal and rectal pain.

Frequent urination

Frequent urination does not always happen because of bladder irritation or urinary tract infection; it can also be a silent sign of uterine fibroids. This symptom mainly develops if you’re suffering from subserosal fibroids, which protrude outside the uterus and cause a frequent urge to urinate. In certain instances, pressure in the bladder and its surrounding organs can also cause this symptom.

Prolonged menstruation

Not only heavy menstruation but uterine fibroids can also cause prolonged menstrual cycles. Herein, you must note that fibroids can interfere with hormone production and enlarge uterine lining which can be associated with prolonged menstruation. Along with this, these fibroids can also distort the blood flow inside the uterus which can make the uterine lining take longer for shedding blood.

Anemia

Are you witnessing a sudden drop in red blood cells? Don’t delay anymore and get an ultrasound done. This is because the heavy and prolonged periods associated with uterine fibroids increase your likelihood of suffering from anemia. In most cases, submucosal or small fibroids are more likely to cause heavy bleeding.

Fertility Issues

Another serious and silent symptom of fibroids is fertility issues. If the fibroids are not cured at the right time then it can stop implantation of a fertilized egg in the uterus or can block the fallopian tubes for a successful fertilization. These complications associated with fibroids can cause infertility when the fibroids need to be treated first to attain a successful pregnancy. It is true that signs of uterine fibroids can vary from person to person but if you experience any of the above-mentioned symptoms then you must contact the best gynecologist in Siliguri immediately. You must know that the treatment for these fibroids has high success rates so get your treatment done and attain relief from the problematic symptoms.