#Serological Antidotes

[forensicfield]

Antidote & It's Types

Antidotes are substances that counteract the effects of poisons and toxins. Antidotes work by stopping the toxin from being absorbed, binding and neutralising the poison, antagonising the poison's end-organ impact, or inhibiting the toxin's conversion....

(more…)

[juniperpublishers-toxicology]

Fulminant hepatic failure induced by antipsychotic drugs (a case report)

Introduction

Fulminant hepatitis is a rare condition but has a very poor prognosis in the absence of liver transplantation. It is important to identify the cause as soon as possible to start the etiological treatment, which may be drug poisoning, viral hepatitis, or alcoholic ... [1-3]. N-acetylcysteine (NAC), a glutathione precursor, was first used as a treatment for paracetamol overdose in 1979. Since then, it has been firmly established as an effective and safe treatment for paracetamol induced IHC prevention. NAC has also been shown to be effective outside paracetamol intoxication. It has been evaluated as an option for acute IHC other than paracetamol in adults and children. In a randomized clinical trial comparing NAC with placebo in adults with paracetamol-free IHC, NAC was associated with a marked improvement in survival without liver transplantation [4]. NAC has also been evaluated for non-hepatic clinical conditions, these indications include its use in lung diseases (COPD and pulmonary fibrosis), in the prevention of contrast-induced nephrotoxicity and for the treatment of certain cardiac diseases [3,5]. In this article, we report the case of a neuroleptic overdose in a 16-year-old who has rapidly progressed to fulminant hepatitis. The oral administration of N-acetylcysteine has allowed a dramatic improvement [3].

Observation

A 16-year-old man consulted at the emergency reception service (j1) for asthenia, disabling diffuse myalgia and uncontrollable vomiting, in the context of cutaneous-mucous jaundice, which had appeared for 4 days. Her antecedents included herpetic keratitis since the age of 3 years and chronic epigastralgia for 4 years. In the emergency department, the clinical examination found a sleepy, sleepy patient, a conjunctival subitem, muscle pain with manual pressure. The temperature was 37.8°C, and blood glucose was 2.2mmol/l. The blood pressure was 85/38 mmHg, the heart rate was 104 beats per minute and 95% saturation in the air. The biochemical assessment was very disturbed, with: an inflammatory syndrome (C-reactive protein at 150 mg/L, fibrinogen at 6.6g/L), renal insufficiency (urea at 14.4mmol/L, creatinine at 159 , 12mmol/L), cytolysis (ASAT: 10454 IU/L, ALA at 4408 IU/L), cholestasis (conjugated bilirubinemia at 151mmol/L, gamma GT at 489 IU / L, PAL at 657 IU/L ) and a disturbance of its hemostasis (TP <15%, a TCA at 96.4 s and a very collapsed factor V). The hemogram showed the following: white blood cells at 9210mm-3, platelets at 159 000mm-3 and hemoglobin at 11.2g/dl.

On the diagnosis side

The patient was admitted to intensive care (1st day). Etiologically, an infectious hypothesis has been ruled out by the negativity of his liver serologies (anti-HVA Ab, anti-HBV Ab and HBs antigen and anti-HCV antibodies) as well as the serology of CMV, the abdominal ultrasound was without particularities, blood ceruloplasmin level was normal, anti-smooth muscle and antimitochondrial antibodies were achieved returning normal. The preferred toxic hypothesis was a neuroleptic overdose because the interview reported a prescription of 3 different neuroleptics, by his doctor for his chronic epigastralgia of psychogenic origin (Olanzapine, Mainspring and Metoclopramide). Supported: Symptomatic treatment consisted of stopping neuroleptics, infusion of fresh frozen plasma, vitamin K, laxatives and ciprofloxacin were initiated associated with administration of N-acetylcysteine with a dose of oral load of 140mg/kg followed by a dose of 70mg/kg/day maintenance for 48 hours.

Evolution

The evolution was quickly favorable. Hyper-bilirubinemia was divided by five in three days, the state of consciousness improved rapidly with appearance of an asterixis, the correction of the hemostasis disorder was more progressive with normalization towards the 4th day (Figure 1), a dramatic improvement in hepatic transaminases was observed as early as the second day (Figure 2). The patient left the intensive care unit to the gastric department on day 6. The symptomatic treatment was continued until day 10, the PBH was performed on day 11 without abnormality then he left the hospital on day 17.

Discussion

IHA is defined as a sudden failure of liver function in a patient with no history of liver disease. The cardinal signs of hepatic failure include coagulopathies and hepatic encephalopathy of any grade in the context of acute liver injury [4]. Currently, there is no scientifically proven beneficial treatment in the treatment of IHC, apart from liver transplantation Lee [5]. More than 1000 drugs have been listed as being responsible of hepatic side effects; 16% of these agents were neuropsychiatric drugs. Antidepressant drugs (tricyclic agents or SSRI), mood stabilizing agents and neuroleptic drugs have been implicated in biological or/and clinical hepatotoxicity. For these reasons, some psychotropic agents have been withdrawn of the pharmaceutical, On the contrary, in case of clinical hepatotoxicity, challenge or maintenance is absolutely inadvisable. Mechanism of the hepatic troubles: precise mechanisms of the hepatotoxicity remain unclear. Contrary to phenothiazine drugs, no information is available on the respective rule of the agents and their metabolites. Hypersensitivity syndrome or eosinophilia has been reported, suggesting a possible immuno-allergic mechanism. Presence of risk factors: risk factors have been retrieved, in some observations, like high daily dosage, high plasmatic concentration, age, alcoholism, obesity or antecedent of hepatic disorders like Gilbert syndrome. [6] Special care is advisable with these patients. As hepatotoxicity has been observed after surd Osage (or suicide attempt), a hepatic check-up has to be performed in these clinical situations [7]. Co-medication with hepatotoxic drugs may increase the risk as it has been suggested. Acetylcysteine is a precursor of glutathione. It is well known as an antidote for acetaminophen overdose due to its ability to increase glutathione levels, which inactivates the toxic metabolite of acetaminophen [8]. N-acetyl-pbenzoquinone mine. Glutathione is a major antioxidant that can serve as a scavenger for free radicals; therefore, acetylcysteine may increase glutathione stock during periods of oxidative stress, increase nitric oxide production, which causes vasodilation and therefore tissue oxygenation, and may also have an antiinflammatory effect. by inhibition of pro-inflammatory factors (TNF alfa and IL8) [9,10]. The majority of studies evaluated the use of NAC in acute IHC secondary to acetaminophen poisoning. There is little research on the use of NAC in IHC secondary to other causes. Hu [8]. evaluated the efficacy of NAC in patients with non-acetaminophen-overdosed IHC (safety and efficacy of NAC in patients with ALF not caused by acetaminophen overdose), in a meta-analysis, which consisted of analyzing four assays prospective clinical trials evaluating NAC versus placebo in the treatment of non-acetaminophen-induced IHC[3].

Conclusion

NAC is a beneficial treatment in the context of nonparacetamol induced IHC, it can prolong the survival of patients with or without liver transplantation and survival after transplantation, but it cannot improve overall survival. Therefore, due to the lack of available scientific evidence, current data is unable to conclusively determine the role of NAC in patients with IHC without paracetamol. Thus, they are unable to make recommendations for clinical practice.

[gordonwilliamsweb]

COVID Survivors’ Blood Plasma Is A Sought-After New Commodity

Diana Berrent learned she had tested positive for COVID-19 on a Wednesday in mid-March. Within a day, she had received 30 emails from people urging her to donate blood.

Friends and acquaintances, aware of her diagnosis, passed along a pressing request from New York’s Mount Sinai Health System, one of the first centers to seek plasma, a blood component, to be used in a therapy that might fight the deadly disease. Berrent, 45, said she immediately recognized the need for the precious plasma — and the demand that would follow.

“When I saw that email going around, I saw what was going to happen in the landscape,” said Berrent, a photographer and mother of two who lives on Long Island. She went on to found Survivor Corps, a grassroots clearinghouse that connects people who have recovered from COVID-19 with organizations eager to collect their blood.

“What I saw was going to emerge was a free market where survivors were a commodity.”

Nearly two months later, Berrent’s prediction is coming true. The coronavirus has infected more than 1.2 million people in the U.S., and now government scientists, academic researchers and for-profit pharmaceutical firms all are scrambling for blood plasma from COVID-19 survivors in hopes of developing a range of potential treatments.

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In Minnesota, a program coordinated by the Mayo Clinic has collected plasma from more than 12,000 COVID survivors for transfusion into more than 7,000 gravely ill patients, the result of a massive public appeal led by government leaders and nonprofit groups like the Red Cross.

Meanwhile, for-profit companies that typically pay $50 per donation of plasma used in other lifesaving therapies are advertising aggressively — and significantly bumping up their rates for COVID donors.

In Utah, John and Melanie Haering, who contracted COVID-19 aboard the ill-fated Diamond Princess cruise ship, received gift cards worth $800 after making two donations apiece at a Takeda Pharmaceuticals BioLife Plasma Services center. BioLife runs several of the more than 800 paid-plasma collection sites in the U.S., part of an industry that produces plasma protein therapies used to treat rare, chronic conditions such as hemophilia and in medical emergencies.

John and Melanie Haering contracted COVID-19 aboard the cruise ship Diamond Princess. BioLife, a paid plasma collection site, gave the Haerings gift cards totaling $800 for donations of their blood plasma — to be used for possible therapy for those battling the disease.(Courtesy of the Haerings)

“Given the urgency and importance of collecting convalescent plasma from the small population of recovered COVID-19 patients, BioLife is currently offering an added incentive for the first two donations from recovered COVID-19 patients,” Takeda spokesperson Julia Ellwanger said in an email.

The money was “a nice surprise” for the Haerings, though they said they were motivated more by the opportunity to prevent others from suffering.

“If we could help anybody, we’d go every day,” said John Haering, 63, a retired railroad manager who spent two weeks in a hospital in Japan after testing positive for the virus.

Donors like Berrent and the Haerings are needed to supply the building blocks of potentially lifesaving treatments. Rich with antibodies, convalescent plasma from COVID-19 patients is being tested as a possible therapy to promote recovery in people who are critically ill with the disease.

It’s also being collected to create a concentrated antibody serum known as hyperimmune globulin that may prevent or halt infection in the future. Similar products are used to treat rabies and illnesses like infant botulism. If plasma from COVID-19 donors is shown to halt the disease, coming up with an antidote could offer companies the prospect of making millions of dollars.

And there’s the possibility of a third treatment, monoclonal antibody therapy, which would use antibody-producing cells from high-antibody donors to create lab-produced molecules to fight the disease.

All three therapies are promising, but all three require human blood plasma, said Dr. Michael Busch, a professor of laboratory medicine at the University of California-San Francisco and director of the Vitalant Research Institute, one of the largest blood center-based transfusion medicine research programs in the U.S.

“At some level, they’re all competing with the regular blood banks like mine,” Busch said.

Only a fraction of those infected with COVID-19 have recovered sufficiently to donate, though more are eligible every day. But as demand for donors has grown, so has the need to wrangle the supply, ensuring that competition for plasma doesn’t undercut the larger mission, said Dr. Michael Joyner, who heads the Mayo Clinic program.

“We’re going to get it all worked out,” he said. “It’s in everybody’s enlightened self-interest to do this in an intelligent way.”

To avoid what Joyner described as a “range war” for COVID-19 plasma, he’s spearheading an effort that calls for unprecedented collaboration to distribute separate streams of plasma among producers of therapies in a global market estimated to reach $35.5 billion by 2023.

“It’s like the oil market,” he said. “You send oil that needs one type of refining to one market and oil that needs another type of refining to another market.”

His plan — floated last month to a group that included representatives from philanthropic organizations along with executives from for-profit and nonprofit blood collectors — relies in part on blood plasma from up to 10,000 Hasidic women in New York City, where the Orthodox Jewish community has been hit hard by the disease.

Tens of thousands of people have fallen ill with the virus in the city’s Hasidic neighborhoods, and more than 700 have died. In recent weeks, thousands of men in the community who have recovered from COVID-19 have rushed to donate plasma. Chaim Lebovits, 45, who has helped organize the effort, said the donations are an act of faith.

“We have an obligation to protect and save lives,” Lebovits said.

So far, however, many women in the Hasidic community have been unable to participate. Hasidic families are often large, and women who have had several children may have high levels of certain antibodies that are sometimes produced during a pregnancy. Rarely, such antibodies can cause a dangerous reaction — transfusion-related acute lung injury — in some recipients of plasma from women who have been pregnant. In COVID-19 patients, battling a virus that targets the lungs, such reactions could be deadly.

Given the risk, many Hasidic mothers who want to join the men in donating have been deferred from providing plasma for immediate transfusion, Joyner said. But those women could be an ideal and ongoing source of plasma for hyperimmune globulin, which is processed in a way that dilutes or removes the antibodies.

Roughly 10,000 women could donate up to four times each, generating some 30,000 liters of COVID-19 plasma that could be directed to the for-profit collectors to make hyperimmune globulin, Joyner estimated. That’s enough for the companies to get started.

“This is the basis of a true win-win,” Joyner said.

In the future, other groups deemed ineligible to provide convalescent plasma for transfusion, out of concern about disease transmission, could be diverted for hyperimmune globulin creation, he said.

One key part of the plan will be the ability to identify eligible donors through antibody tests, Joyner said. Mayo Clinic scientists have already conducted more than 5,000 serology tests and identified hundreds of potential plasma donors.

So far, however, neither the nonprofit organizations nor the for-profit firms have agreed to the plan.

“Ways to facilitate these donations and recommendations for how to allocate donors to one donation stream or the other are still in progress,” said Natalie de Vane, a spokesperson for CSL Behring, a biopharmaceutical company based in King of Prussia, Pennsylvania.

CSL has joined with Takeda, a Japanese pharmaceutical company, to lead the CoVIg-19 Plasma Alliance, a coalition of six companies developing a single, unbranded hyperimmune globulin product that could treat COVID-19.

Meanwhile, officials with the AABB, an international nonprofit focused on transfusion medicine and cellular therapies, have focused efforts primarily on collecting plasma for immediate use. But they acknowledged that convalescent plasma could end up serving as “bridge therapy” to buy time until the hyperimmune globulin products are available.

“AABB recognizes the importance of ensuring that convalescent plasma is available as a transfusion therapy for patients today, as well as to develop future treatments,” the agency said in a statement.

Representatives from all sides agree that the most pressing need is to increase the pool of COVID-19 survivors willing to donate plasma. They downplay talk of jockeying for donors in the nonprofit and for-profit worlds.

“We don’t view it as competition,” said Chris Healey, president of corporate affairs at Grifols, a Spanish pharmaceutical company that has received nearly $13 million in funding from the U.S. Department of Defense to develop its own hyperimmune globulin product. “We’re all pointed in the same direction.”

One solution may be groups like Berrent’s nonprofit Survivor Corps, which started in late March with a Facebook group that’s grown to 42,000 members and now includes international partnerships and a pro bono advertising campaign, A Call to Arms.

Berrent has given plasma four times now, including to a biotech firm that sent a phlebotomist to her home and gave her a $100 Amazon card for her trouble.

Survivor Corps aims to function as a “one-stop shop” for donors interested in giving COVID-19 plasma, said Berrent. And, she said, it also could serve as a single source for recruitment, freeing scientists in government, academia and industry to focus on finding answers, not scouting survivors.

“Free markets work beautifully in many, many situations,” said Berrent. “During a global pandemic, during a time of crisis, we need collaboration and efficiency.”

COVID Survivors’ Blood Plasma Is A Sought-After New Commodity published first on https://nootropicspowdersupplier.tumblr.com/

[dinafbrownil]

COVID Survivors’ Blood Plasma Is A Sought-After New Commodity

Diana Berrent learned she had tested positive for COVID-19 on a Wednesday in mid-March. Within a day, she had received 30 emails from people urging her to donate blood.

Friends and acquaintances, aware of her diagnosis, passed along a pressing request from New York’s Mount Sinai Health System, one of the first centers to seek plasma, a blood component, to be used in a therapy that might fight the deadly disease. Berrent, 45, said she immediately recognized the need for the precious plasma — and the demand that would follow.

“When I saw that email going around, I saw what was going to happen in the landscape,” said Berrent, a photographer and mother of two who lives on Long Island. She went on to found Survivor Corps, a grassroots clearinghouse that connects people who have recovered from COVID-19 with organizations eager to collect their blood.

“What I saw was going to emerge was a free market where survivors were a commodity.”

Nearly two months later, Berrent’s prediction is coming true. The coronavirus has infected more than 1.2 million people in the U.S., and now government scientists, academic researchers and for-profit pharmaceutical firms all are scrambling for blood plasma from COVID-19 survivors in hopes of developing a range of potential treatments.

Email Sign-Up

Subscribe to KHN’s free Morning Briefing.

Sign Up

Please confirm your email address below:

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In Minnesota, a program coordinated by the Mayo Clinic has collected plasma from more than 12,000 COVID survivors for transfusion into more than 7,000 gravely ill patients, the result of a massive public appeal led by government leaders and nonprofit groups like the Red Cross.

Meanwhile, for-profit companies that typically pay $50 per donation of plasma used in other lifesaving therapies are advertising aggressively — and significantly bumping up their rates for COVID donors.

In Utah, John and Melanie Haering, who contracted COVID-19 aboard the ill-fated Diamond Princess cruise ship, received gift cards worth $800 after making two donations apiece at a Takeda Pharmaceuticals BioLife Plasma Services center. BioLife runs several of the more than 800 paid-plasma collection sites in the U.S., part of an industry that produces plasma protein therapies used to treat rare, chronic conditions such as hemophilia and in medical emergencies.

John and Melanie Haering contracted COVID-19 aboard the cruise ship Diamond Princess. BioLife, a paid plasma collection site, gave the Haerings gift cards totaling $800 for donations of their blood plasma — to be used for possible therapy for those battling the disease.(Courtesy of the Haerings)

“Given the urgency and importance of collecting convalescent plasma from the small population of recovered COVID-19 patients, BioLife is currently offering an added incentive for the first two donations from recovered COVID-19 patients,” Takeda spokesperson Julia Ellwanger said in an email.

The money was “a nice surprise” for the Haerings, though they said they were motivated more by the opportunity to prevent others from suffering.

“If we could help anybody, we’d go every day,” said John Haering, 63, a retired railroad manager who spent two weeks in a hospital in Japan after testing positive for the virus.

Donors like Berrent and the Haerings are needed to supply the building blocks of potentially lifesaving treatments. Rich with antibodies, convalescent plasma from COVID-19 patients is being tested as a possible therapy to promote recovery in people who are critically ill with the disease.

It’s also being collected to create a concentrated antibody serum known as hyperimmune globulin that may prevent or halt infection in the future. Similar products are used to treat rabies and illnesses like infant botulism. If plasma from COVID-19 donors is shown to halt the disease, coming up with an antidote could offer companies the prospect of making millions of dollars.

And there’s the possibility of a third treatment, monoclonal antibody therapy, which would use antibody-producing cells from high-antibody donors to create lab-produced molecules to fight the disease.

All three therapies are promising, but all three require human blood plasma, said Dr. Michael Busch, a professor of laboratory medicine at the University of California-San Francisco and director of the Vitalant Research Institute, one of the largest blood center-based transfusion medicine research programs in the U.S.

“At some level, they’re all competing with the regular blood banks like mine,” Busch said.

Only a fraction of those infected with COVID-19 have recovered sufficiently to donate, though more are eligible every day. But as demand for donors has grown, so has the need to wrangle the supply, ensuring that competition for plasma doesn’t undercut the larger mission, said Dr. Michael Joyner, who heads the Mayo Clinic program.

“We’re going to get it all worked out,” he said. “It’s in everybody’s enlightened self-interest to do this in an intelligent way.”

To avoid what Joyner described as a “range war” for COVID-19 plasma, he’s spearheading an effort that calls for unprecedented collaboration to distribute separate streams of plasma among producers of therapies in a global market estimated to reach $35.5 billion by 2023.

“It’s like the oil market,” he said. “You send oil that needs one type of refining to one market and oil that needs another type of refining to another market.”

His plan — floated last month to a group that included representatives from philanthropic organizations along with executives from for-profit and nonprofit blood collectors — relies in part on blood plasma from up to 10,000 Hasidic women in New York City, where the Orthodox Jewish community has been hit hard by the disease.

Tens of thousands of people have fallen ill with the virus in the city’s Hasidic neighborhoods, and more than 700 have died. In recent weeks, thousands of men in the community who have recovered from COVID-19 have rushed to donate plasma. Chaim Lebovits, 45, who has helped organize the effort, said the donations are an act of faith.

“We have an obligation to protect and save lives,” Lebovits said.

So far, however, many women in the Hasidic community have been unable to participate. Hasidic families are often large, and women who have had several children may have high levels of certain antibodies that are sometimes produced during a pregnancy. Rarely, such antibodies can cause a dangerous reaction — transfusion-related acute lung injury — in some recipients of plasma from women who have been pregnant. In COVID-19 patients, battling a virus that targets the lungs, such reactions could be deadly.

Given the risk, many Hasidic mothers who want to join the men in donating have been deferred from providing plasma for immediate transfusion, Joyner said. But those women could be an ideal and ongoing source of plasma for hyperimmune globulin, which is processed in a way that dilutes or removes the antibodies.

Roughly 10,000 women could donate up to four times each, generating some 30,000 liters of COVID-19 plasma that could be directed to the for-profit collectors to make hyperimmune globulin, Joyner estimated. That’s enough for the companies to get started.

“This is the basis of a true win-win,” Joyner said.

In the future, other groups deemed ineligible to provide convalescent plasma for transfusion, out of concern about disease transmission, could be diverted for hyperimmune globulin creation, he said.

One key part of the plan will be the ability to identify eligible donors through antibody tests, Joyner said. Mayo Clinic scientists have already conducted more than 5,000 serology tests and identified hundreds of potential plasma donors.

So far, however, neither the nonprofit organizations nor the for-profit firms have agreed to the plan.

“Ways to facilitate these donations and recommendations for how to allocate donors to one donation stream or the other are still in progress,” said Natalie de Vane, a spokesperson for CSL Behring, a biopharmaceutical company based in King of Prussia, Pennsylvania.

CSL has joined with Takeda, a Japanese pharmaceutical company, to lead the CoVIg-19 Plasma Alliance, a coalition of six companies developing a single, unbranded hyperimmune globulin product that could treat COVID-19.

Meanwhile, officials with the AABB, an international nonprofit focused on transfusion medicine and cellular therapies, have focused efforts primarily on collecting plasma for immediate use. But they acknowledged that convalescent plasma could end up serving as “bridge therapy” to buy time until the hyperimmune globulin products are available.

“AABB recognizes the importance of ensuring that convalescent plasma is available as a transfusion therapy for patients today, as well as to develop future treatments,” the agency said in a statement.

Representatives from all sides agree that the most pressing need is to increase the pool of COVID-19 survivors willing to donate plasma. They downplay talk of jockeying for donors in the nonprofit and for-profit worlds.

“We don’t view it as competition,” said Chris Healey, president of corporate affairs at Grifols, a Spanish pharmaceutical company that has received nearly $13 million in funding from the U.S. Department of Defense to develop its own hyperimmune globulin product. “We’re all pointed in the same direction.”

One solution may be groups like Berrent’s nonprofit Survivor Corps, which started in late March with a Facebook group that’s grown to 42,000 members and now includes international partnerships and a pro bono advertising campaign, A Call to Arms.

Berrent has given plasma four times now, including to a biotech firm that sent a phlebotomist to her home and gave her a $100 Amazon card for her trouble.

Survivor Corps aims to function as a “one-stop shop” for donors interested in giving COVID-19 plasma, said Berrent. And, she said, it also could serve as a single source for recruitment, freeing scientists in government, academia and industry to focus on finding answers, not scouting survivors.

“Free markets work beautifully in many, many situations,” said Berrent. “During a global pandemic, during a time of crisis, we need collaboration and efficiency.”

from Updates By Dina https://khn.org/news/covid-survivors-blood-plasma-is-a-sought-after-new-commodity/

[stephenmccull]

COVID Survivors’ Blood Plasma Is A Sought-After New Commodity

Diana Berrent learned she had tested positive for COVID-19 on a Wednesday in mid-March. Within a day, she had received 30 emails from people urging her to donate blood.

Friends and acquaintances, aware of her diagnosis, passed along a pressing request from New York’s Mount Sinai Health System, one of the first centers to seek plasma, a blood component, to be used in a therapy that might fight the deadly disease. Berrent, 45, said she immediately recognized the need for the precious plasma — and the demand that would follow.

“When I saw that email going around, I saw what was going to happen in the landscape,” said Berrent, a photographer and mother of two who lives on Long Island. She went on to found Survivor Corps, a grassroots clearinghouse that connects people who have recovered from COVID-19 with organizations eager to collect their blood.

“What I saw was going to emerge was a free market where survivors were a commodity.”

Nearly two months later, Berrent’s prediction is coming true. The coronavirus has infected more than 1.2 million people in the U.S., and now government scientists, academic researchers and for-profit pharmaceutical firms all are scrambling for blood plasma from COVID-19 survivors in hopes of developing a range of potential treatments.

Email Sign-Up

Subscribe to KHN’s free Morning Briefing.

Sign Up

Please confirm your email address below:

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In Minnesota, a program coordinated by the Mayo Clinic has collected plasma from more than 12,000 COVID survivors for transfusion into more than 7,000 gravely ill patients, the result of a massive public appeal led by government leaders and nonprofit groups like the Red Cross.

Meanwhile, for-profit companies that typically pay $50 per donation of plasma used in other lifesaving therapies are advertising aggressively — and significantly bumping up their rates for COVID donors.

In Utah, John and Melanie Haering, who contracted COVID-19 aboard the ill-fated Diamond Princess cruise ship, received gift cards worth $800 after making two donations apiece at a Takeda Pharmaceuticals BioLife Plasma Services center. BioLife runs several of the more than 800 paid-plasma collection sites in the U.S., part of an industry that produces plasma protein therapies used to treat rare, chronic conditions such as hemophilia and in medical emergencies.

John and Melanie Haering contracted COVID-19 aboard the cruise ship Diamond Princess. BioLife, a paid plasma collection site, gave the Haerings gift cards totaling $800 for donations of their blood plasma — to be used for possible therapy for those battling the disease.(Courtesy of the Haerings)

“Given the urgency and importance of collecting convalescent plasma from the small population of recovered COVID-19 patients, BioLife is currently offering an added incentive for the first two donations from recovered COVID-19 patients,” Takeda spokesperson Julia Ellwanger said in an email.

The money was “a nice surprise” for the Haerings, though they said they were motivated more by the opportunity to prevent others from suffering.

“If we could help anybody, we’d go every day,” said John Haering, 63, a retired railroad manager who spent two weeks in a hospital in Japan after testing positive for the virus.

Donors like Berrent and the Haerings are needed to supply the building blocks of potentially lifesaving treatments. Rich with antibodies, convalescent plasma from COVID-19 patients is being tested as a possible therapy to promote recovery in people who are critically ill with the disease.

It’s also being collected to create a concentrated antibody serum known as hyperimmune globulin that may prevent or halt infection in the future. Similar products are used to treat rabies and illnesses like infant botulism. If plasma from COVID-19 donors is shown to halt the disease, coming up with an antidote could offer companies the prospect of making millions of dollars.

And there’s the possibility of a third treatment, monoclonal antibody therapy, which would use antibody-producing cells from high-antibody donors to create lab-produced molecules to fight the disease.

All three therapies are promising, but all three require human blood plasma, said Dr. Michael Busch, a professor of laboratory medicine at the University of California-San Francisco and director of the Vitalant Research Institute, one of the largest blood center-based transfusion medicine research programs in the U.S.

“At some level, they’re all competing with the regular blood banks like mine,” Busch said.

Only a fraction of those infected with COVID-19 have recovered sufficiently to donate, though more are eligible every day. But as demand for donors has grown, so has the need to wrangle the supply, ensuring that competition for plasma doesn’t undercut the larger mission, said Dr. Michael Joyner, who heads the Mayo Clinic program.

“We’re going to get it all worked out,” he said. “It’s in everybody’s enlightened self-interest to do this in an intelligent way.”

To avoid what Joyner described as a “range war” for COVID-19 plasma, he’s spearheading an effort that calls for unprecedented collaboration to distribute separate streams of plasma among producers of therapies in a global market estimated to reach $35.5 billion by 2023.

“It’s like the oil market,” he said. “You send oil that needs one type of refining to one market and oil that needs another type of refining to another market.”

His plan — floated last month to a group that included representatives from philanthropic organizations along with executives from for-profit and nonprofit blood collectors — relies in part on blood plasma from up to 10,000 Hasidic women in New York City, where the Orthodox Jewish community has been hit hard by the disease.

Tens of thousands of people have fallen ill with the virus in the city’s Hasidic neighborhoods, and more than 700 have died. In recent weeks, thousands of men in the community who have recovered from COVID-19 have rushed to donate plasma. Chaim Lebovits, 45, who has helped organize the effort, said the donations are an act of faith.

“We have an obligation to protect and save lives,” Lebovits said.

So far, however, many women in the Hasidic community have been unable to participate. Hasidic families are often large, and women who have had several children may have high levels of certain antibodies that are sometimes produced during a pregnancy. Rarely, such antibodies can cause a dangerous reaction — transfusion-related acute lung injury — in some recipients of plasma from women who have been pregnant. In COVID-19 patients, battling a virus that targets the lungs, such reactions could be deadly.

Given the risk, many Hasidic mothers who want to join the men in donating have been deferred from providing plasma for immediate transfusion, Joyner said. But those women could be an ideal and ongoing source of plasma for hyperimmune globulin, which is processed in a way that dilutes or removes the antibodies.

Roughly 10,000 women could donate up to four times each, generating some 30,000 liters of COVID-19 plasma that could be directed to the for-profit collectors to make hyperimmune globulin, Joyner estimated. That’s enough for the companies to get started.

“This is the basis of a true win-win,” Joyner said.

In the future, other groups deemed ineligible to provide convalescent plasma for transfusion, out of concern about disease transmission, could be diverted for hyperimmune globulin creation, he said.

One key part of the plan will be the ability to identify eligible donors through antibody tests, Joyner said. Mayo Clinic scientists have already conducted more than 5,000 serology tests and identified hundreds of potential plasma donors.

So far, however, neither the nonprofit organizations nor the for-profit firms have agreed to the plan.

“Ways to facilitate these donations and recommendations for how to allocate donors to one donation stream or the other are still in progress,” said Natalie de Vane, a spokesperson for CSL Behring, a biopharmaceutical company based in King of Prussia, Pennsylvania.

CSL has joined with Takeda, a Japanese pharmaceutical company, to lead the CoVIg-19 Plasma Alliance, a coalition of six companies developing a single, unbranded hyperimmune globulin product that could treat COVID-19.

Meanwhile, officials with the AABB, an international nonprofit focused on transfusion medicine and cellular therapies, have focused efforts primarily on collecting plasma for immediate use. But they acknowledged that convalescent plasma could end up serving as “bridge therapy” to buy time until the hyperimmune globulin products are available.

“AABB recognizes the importance of ensuring that convalescent plasma is available as a transfusion therapy for patients today, as well as to develop future treatments,” the agency said in a statement.

Representatives from all sides agree that the most pressing need is to increase the pool of COVID-19 survivors willing to donate plasma. They downplay talk of jockeying for donors in the nonprofit and for-profit worlds.

“We don’t view it as competition,” said Chris Healey, president of corporate affairs at Grifols, a Spanish pharmaceutical company that has received nearly $13 million in funding from the U.S. Department of Defense to develop its own hyperimmune globulin product. “We’re all pointed in the same direction.”

One solution may be groups like Berrent’s nonprofit Survivor Corps, which started in late March with a Facebook group that’s grown to 42,000 members and now includes international partnerships and a pro bono advertising campaign, A Call to Arms.

Berrent has given plasma four times now, including to a biotech firm that sent a phlebotomist to her home and gave her a $100 Amazon card for her trouble.

Survivor Corps aims to function as a “one-stop shop” for donors interested in giving COVID-19 plasma, said Berrent. And, she said, it also could serve as a single source for recruitment, freeing scientists in government, academia and industry to focus on finding answers, not scouting survivors.

“Free markets work beautifully in many, many situations,” said Berrent. “During a global pandemic, during a time of crisis, we need collaboration and efficiency.”

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