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The revival of SAARC and the larger question of regional solidarity and integration
Bangladeshi leader Dr Yunus’ call for “a summit of SAARC leaders even if it is only for a photo session because that will carry a strong message” underscores the critical need to make Southasia an effectively interconnected region. If India refuses to travel to Pakistani for a SAARC summit, other alternatives must be thought out, argues a peace studies scholar By Dr. Saeed Ahmed Rid “I am a big…
#NewsMatch#NewsMatch2024#SapanNewsMatch#SapanNewsMatch2024#Dr. Mohammad Yunus#Prime Minister Narendra Modi#saarc#Sapan News Network#Shehbaz Sharif#Southasia Peace Action Network
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The Movie Masters! for American Movie Classics 1989
Albie Hecht (executive producer & co-creator): “My favorite!”
Christine Ecklund (producer/writer): “Wow. Bet I can still answer every question. (“Ucipital Mapilary”)“
Before Mad Men, before Breaking Bad and The Walking Dead, AMC was actually “American Movie Classics,” the Turner Classic Movies of its time, a cable channel exclusively focused on, duh, movies from the heyday of Hollywood. (In fact, the former head of AMC programming created TMC.)
Towards the end of the 80s, channels that relied on acquired, cost efficient stuff like AMC (or Nick-at-Night or USA or even MTV) were realizing that advertisers and cable operators were on the hunt for programming that could excite viewers.
The Movie Masters was one of AMC’s first jump into the pool, and obviously, it wasn’t the approach that worked like crazy for them. Fred/Alan’s primary Showtime client, Josh Sapan, had become AMC’s leader and thought that our Chauncey Street Productions had an idea for a network series.
Original television production, even when it’s done efficiently, is pretty expensive. And the explosion of cable TV had exploded in terms of dozens of channels, but it was still trying to figure out how to make enough money to thrive. The financial picture wouldn’t really come into it’s own until the end of the 1990′s. All the networks we worked with over the years approached originals very gingerly, and American Movie Classics was one of the most, um, fiscally careful.
Well, Chauncey Street was a perfect fit for a deliberate situation. We were still feeling our way in series production and we were well aware we weren’t yet booking the big gigs.
Chauncey Street majordomo Albie Hecht loved game shows (CSP went on to produce Turn It Up! for MTV, Kid’s Court and GUTS for Nickelodeon, and Albie oversaw many more as president of Nickelodeon production). He and Alan created the idea for The Movie Masters, with the notion that it would recreate the salad days of broadcast network quiz shows.
To that end we ran dozens of casting calls at our office, talking to everyone from Betty Comden and Margaret Whiting, before coming to the conclusion that we’d replicate a classic quiz show line up (American Movie Classics, right!). The production landed on The Match Game’s Gene Rayburn as host, and actress and veteran quiz panelist Peggy Cass, New York Times’ theater critic Clive Barnes, and actress and To Tell the Truth stalwart Kitty Carlisle as contestants.
The production came off with only a few hitches and delivered on time and on budget. It was a hoot working with such revered acting, writing and television royalty. AMC would eventually find their way to “prestige” TV, but as far as we were concerned, we did a wonderful job in the name of the greatest movies of all time.
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Chauncey Street Productions, New York Created by Albie Hecht & Alan Goodman Producer/writer: Christine Ecklund Executive Producers: Alan Goodman, Albie Hecht, Fred Seibert
Three of the original episodes of "The Movie Masters"
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#AMC#American Movie Classics#Josh Sapan#The Movie Masters#1989#Chauncey Street#Albie Hecht#Alan Goodman#Fred Seibert
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From Deadline: New AMC CEO Christina Spade, Replaces Interim CEO Matt Blank
AMC Networks Ups Christina Spade To CEO Post; Patrick O’Connell To Take On CFO Role
AMC Networks has appointed COO and CFO Christina Spade as its new CEO, succeeding Matt Blank, who has held the role in an interim capacity since last September.
Patrick O’Connell, previously a senior executive at CBS Corp and Goldman Sachs, has in turn been named Executive Vice President, Chief Financial Officer, reporting to Spade.
Blank will remain with AMC Networks until the end of the year in a consultancy role, a spokeswoman confirmed.
AMC Networks operates cable channels such as AMC, plus streaming services AMC+, Sundance Now and Acorn TV. Spade will lead them all from September 9 when she steps into the new role.
Today’s development, which comes as the business reports its second quarter results, marks a fast rise for Spade at AMC Networks. She has been with the New York-headquartered operations since January 2021, where she joined as Executive Vice President, Chief Financial Officer, and took on a dual role as CFO and COO in November last year.
During that time, she has worked under Blank, who was named interim CEO last September as previous Chief Exec and President Josh Sapan moved to an Executive Vice Chairman position. While the network is known for launching influential cable hits such as Better Call Saul, The Walking Dead and Mad Men, Showtime veteran Blank has focused heavily on building out the streaming business, which currently has an aggregate of 10.8 million subscribers and is expecting to hit 20-25 million in 2025.
The hire comes at a time of change for AMC Networks. The Walking Dead franchise is moving into a new era, with the original series set to end after its next tranche of episodes and several spin-off series launching. Anthology series Tales of the Walking Dead is due to land on August 14, while series featuring fan favorites Rick Grimes (Andrew Lincoln) and Michonne (Danai Gurira), Negan (Jeffrey Dean Morgan) and Maggie Green (Lauren Cohan), and Daryl (Norman Reedus) are forthcoming. Newer series include Moonhaven, Dark Winds and This is Going to Hurt and upcoming titles include Anne Rice’s Interview with the Vampire.
Blank said: “It’s been a pleasure to lead AMC Networks in this interim role, in particular working alongside Chris and the talented team to help develop the company’s direct-to-consumer businesses and strong pipeline of high-quality content. Chris is a strong, versatile leader whom I’ve known and worked closely with for more than 20 years, and I know she’ll bring her strong business and leadership skills, and passion for this company, to her new role.”
AMC Networks Chairman James Dolan said: “I want to thank Matt for his leadership over the past year and for the changes he’s brought about in the company and best positioning us for our further pivot into streaming. I’m delighted that Chris is taking over as our new CEO. She is a proven leader with a long track record driving transformative change in media and entertainment and I am confident she has the expertise and vision to guide AMC Networks to greater success.”
Spade said: “I am honored to assume the role of CEO. I’m a fan of this company in every respect, its content, brands, and most importantly, its people and dynamic and inclusive culture. I’m grateful for the support of Jim, our Board of Directors and Matt, and I look forward to working with the strong team here to unlock the rich opportunities that lie ahead.”
Before AMC Networks, Spade was Executive Vice President, Chief Financial Officer of ViacomCBS and before that held the same role CBS Corp. She also performed similar duties for Showtime Networks, spending a total of 21 years in the business overall.
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Leegality Raises $5Mn In Series A Round From IIFL Fintech Fund.
Leegality is a Gurugram-based document infrastructure platform which has recently raised $5Mn in its series A round funding with participation from Mumbai Angels. According to the reports, this startup would utilize the funding to increase customer acquisition speed, invest in its product development and improve customer experience as well.
Founded in 2016 by Prakhar Agrawal, Shivam Singla and Sapan Parekh, Leegality is a digital document workflow startup which allows companies to digitize document logistics.
Looking at its previous statistics, since 2020 it has grown its quarterly revenue by over 13x and 7x its employee strength, also being cash flow positive. Mehekka Oberoi, Fund Manager, IIFL Fintech Fund has stated that digitization is a major priority of all major BFSI companies today and Leegality is the first major early-stage investment into a legal-fintech company in India.
The company raised an undisclosed amount in 2019 from Mumbai Angels Network, Chandigarh Angels and other high-net-worth individuals. The scope for the space has increased significantly in the last year, especially with the Reserve Bank Of India’s digital lending guidelines, has been stated by Leegality.
This startup also provides document monitoring, security, and signatory verification and automates the verification process along with client-specific charging. Its individual plans are easy as they just have Aadhar and a digital eSign, while the later plans include additional digital verification processes. Suppose the commercial plan additionally includes DocSigner, HSM Signer and a Pan eSign while the business plan also includes DSC and Automated eSign. Not very surprising, but this comprehensive suite of eSign, eStamp, Document Automation products, Compliance Logistics and document security etc is used by 1000+ Indian organizations to digitise their paperwork operations and produce outstanding business results. Its offerings also include three kinds of plans- for individuals, for businesses and last for enterprises.
Whereas the new guidelines impose new digital paperwork requirements for banks and non-banking finance companies while the It act amendment allows the digitization of immovable property contracts and power of attorneys.
The recent investments of IIFL Fintech Fund are FinBos, Datasutram, Multipl, Finarkein, TrustChekr, EasyRewardz and Trendlyne.
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Covid needs a regional response, say participants at 'Neighbours in peace & health' meet | India News
Covid needs a regional response, say participants at ‘Neighbours in peace & health’ meet | India News
BATHINDA: Physicians and health rights activists from across South Asia came together virtually to emphasize that the coronavirus pandemic must be fought collectively. The meeting organised by the South Asia Peace Action Network (SAPAN), the third in the South Asia Peace series focused on health as an entry point to talk about South Asian regionalism and healthcare for all. SAPAN is a coalition…
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Ace Of Spades For Mac
Ace Of Spades Meaning
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download apk 39.7 MB
Publisher:Concrete Software, Inc.
View in Store:Google Play
Download Spades. For macOS 10.6 or later and enjoy it on your Mac. Play Spades with computer partner against two computer opponents. You have to make a bid and then take the number of tricks your.
Build and Shoot is a player-run community for the online voxel FPS game based on Ace of Spades Classic. Login to play the game, interact with players, and customize your experience - it's all 100% free!
Google Play statistics for Aces® SpadesDeveloperSizeTagsDaily ratingsTotal ratingsRelease DateUpdatedTotal installsScoreVersionContent ratingConcrete Software, Inc.39.7 MB 1138,4022012-04-03 2019-11-11 5,000,000+4.22.2.3Everyone
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DescriptionScreenshotsTo see the full description of Aces® Spades, please
Ace Of Spades Meaning
Ace of Spades for Mac combines Minecraft-style gameplay with team death-match online multiplayer competition. Join or create a server, choose the green or red team and get fighting! Work in progress. Still under development, Ace of Spades really does look a lot like Minecraft, with its pixellated blocky style. But the team combat gives it a.
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Aces® Spades Card Game Features: • Play Standard, Mirror, Whiz, or Suicide • 11 distinct animated opponents • 5 difficulty levels and intuitive AI • Customizable bidding options • Gameplay suited for all skill levels • Leaderboards and achievements If you’re looking for the finest card games available for mobile, Aces® has got them in Spades! The team that brought you Aces® Hearts, Aces® Cribbage, and Aces® Solitaire is back with a new offering in the Aces line of quality card games. Aces Spades brings the classic card game to mobile with gorgeous graphics and fully customizable gameplay. You’ll team up with one of 11 beautifully rendered Victorian-era characters to test your skill against a variety of colorful opponents, each with their own unique styles of play. Take tricks, bid nil, and pass to your partner in the most complete Spades experience available for mobile: Aces Spades! ♦♦♦ Permissions requested and how they are used ♦♦♦ • android.permission.INTERNET: This permission is used to: 1) link to our website, 2) link to social networking like Twitter and Facebook, 3) update leaderboards, 4) collect gameplay data that we use to improve our games, and 5) allow ad networks that advertise within the app. • android.permission.ACCESS_NETWORK_STATE: This permission is used primarily to check for a network connection before attempting to connect to our website. • android.permission.WRITE_EXTERNAL_STORAGE: This permission allows the app to access game data saved on an external storage device. • android.permission.READ_PHONE_STATE: This permission allows the app to establish a unique ID for our leaderboards that can be used across all of our applications. • android.permission.ACCESS_WIFI_STATE: This permission allows the app to establish a unique ID for our leaderboards for tablets that do not have telephone information. • android.permission.VIBRATE: This permission is used to access vibration functionality on the device.
App NameDeveloperSizeTagsDaily ratingsTotal ratingsRelease DateUpdatedTotal installsScoreVersionSpades Plus - Card GameZynga98.2 MB-250253,1992014-07-24 2020-10-19 10,000,000+4.55.7.0Spades FreeAI Factory Limited21.7 MB1,482213,6142011-07-27 2020-10-14 5,000,000+4.51.844SpadesKARMAN Games11.6 MB-943,5852011-12-16 2020-10-16 1,000,000+4.31.78VIP Spades - Free Multiplayer GameCasualino Games27.8 MB23,4532016-07-18 2020-08-07 100,000+4.53.6.85Hazari (হাজারী) - 1000 Points Card GameKamal Uddin10.6 MB-1010,8262017-08-03 2020-02-16 1,000,000+4.13.2Callbreak MultiplayerTeslatech Pvt. Ltd.11.2 MB-98197,4622014-11-02 2020-03-26 50,000,000+40.2Hazari Card Game FreeVirtual Beggars4.3 MB101,4072019-02-16 500,000+4.31.0.2Spades Royale - Online Card GamesBeach Bum Ltd.96.0 MB26191,6142018-01-03 2020-09-29 1,000,000+4.71.34.43SpadesFuzzy Mobile Games33.5 MB3934,9642017-07-08 2020-09-28 1,000,000+4.41.11.3Call Break++Jeevan Shrestha10.3 MB-1016,6082014-11-14 2018-12-03 5,000,000+4.21.14Card Game 29Z Level Apps7.9 MB32219,1882014-09-02 2020-10-16 5,000,000+4.35.34Spades Free: Card Game Online and OfflineJogatina.com43.1 MB1312,0462016-12-16 2020-10-14 1,000,000+4.33.1.2SpadesFuzzy Mobile Games32.9 MB207,8472016-10-10 2020-10-08 500,000+4.42.2.1Spades A-Star Software LLC77.5 MB119,5462016-11-11 2020-08-19 1,000,000+4.55.829 Card Game Best EverKamal Uddin5.6 MB22,7002017-09-25 2019-03-06 500,000+4.32.0.329 Card GameKnight's Cave26.4 MB-4545,6922014-06-30 2020-10-19 5,000,000+4.15.2.0Spades FreeGamerHook Studios36.2 MB11,7002017-09-11 2019-02-21 100,000+4.43.1Spades - Card Games FreeArtoon Solutions Private Limited10.4 MB21,0052017-02-11 2020-02-28 100,000+4.29.3Batak Club - Online & Offline Spades GameJoker Game53.4 MB4630,3052015-07-11 2020-10-08 1,000,000+4.27.0.13Spades1C Wireless17.7 MB13,2672014-01-17 2020-09-23 100,000+4.11.1.28Callbreak Gold - MultiplayerWar Magic Games17.5 MB-28,4862018-01-12 2018-08-03 1,000,000+41.0.61Solitaire Classic: KlondikeBitMango36.9 MB011,7502014-02-06 2020-08-20 1,000,000+4.320.0820.09SolitaireLemon Games, Inc15.7 MB-118302,8632016-08-17 2020-04-21 10,000,000+4.64.19.1.20200421Call Bridge Card Game - SpadesKamal Uddin7.3 MB79,2672016-04-30 2019-03-06 1,000,000+4.33.0.6CallBreak & JutPatti - Hamro CardsHamro Patro8.7 MB01,2252017-09-20 2018-09-25 100,000+4.42.1.2Aces® HeartsConcrete Software, Inc.32.1 MB01,3872015-05-06 2020-07-08 100,000+3.72.1.8Euchre Jogatina: Classic Card GameJogatina.com36.5 MB56,3152016-08-02 2020-07-15 500,000+3.93.7.4GameVelvet - Online Card Games and Board Gamesmegajogos.com.br50.1 MB325,7592012-09-27 2020-09-03 1,000,000+4.1101.1.71HeartsFuzzy Mobile Games17.7 MB108,9672015-06-12 2020-08-28 1,000,000+4.32.13.2Sueca Jogatina: Free Card GameJogatina.com19.6 MB19,4242011-02-02 2017-08-11 1,000,000+3.71.5.3HeartsFuzzy Mobile Games31.4 MB64,1222017-07-18 2020-09-28 500,000+4.21.9.1Teen Patti Gold - 3 Patti, Rummy, Poker & CricketMoonfrog65.8 MB-4761,122,6252014-10-08 2020-09-24 50,000,000+4.55.66SolitaireKARMAN Games6.8 MB-3052,8752015-04-13 2020-08-12 5,000,000+4.51.22Spider Solitaire: KingdomBitMango34.6 MB-214,9032017-05-21 2020-07-21 1,000,000+4.420.0722.09Spades GoldMana Battery26.2 MB17,3242014-07-11 2020-03-27 500,000+4.42.1.0Hardwood Spades FreeSilver Creek Entertainment19.1 MB25,4802011-12-19 2020-08-19 100,000+4.42.0.434.0Solitaire Card Games FreeSeaWorld Games33.0 MB1629,1522016-12-02 2020-08-21 1,000,000+4.75.1.0.20200820Spades Offline - Single PlayerCasualino Games13.4 MB15982017-01-17 2020-08-12 100,000+4.52.0.42Spades!Bytesequencing.com,LLC4.8 MB-7255,9592016-03-02 5,000,000+43.2.0Call Break - AceTechnoGuff6.2 MB01,1492016-12-16 2018-03-25 1,000,000+4.318.03.26Marriage Card GameSapan Aryal29.7 MB27,9842014-12-27 2020-05-08 1,000,000+4.112.4Cribbage Club (free cribbage app and board)Nickel Buddy, LLC14.9 MB83,9232013-05-08 2020-07-21 100,000+4.73.2.5Spades by NeuralPlayNeuralPlay, LLC9.5 MB01,8252011-01-02 2020-10-19 100,000+4.13.70Black Spades with Jokers and PrizesKonsole Kingz, LLC92.2 MB07842016-07-21 2020-09-21 100,000+3.63.0.35
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A passionate fighter for a fairer world bows out
Bangladeshi lawyer Sigma Huda passed away recently, at a time when her voice is sorely needed. Journalist Mandira Nayar pays tribute
Sigma Huda– 20 July 2024 Bangladeshi lawyer Sigma Huda passed away recently, at a time when her voice is sorely needed By Mandira Nayar / Sapan News The passing of Sigma Huda leaves a huge void in our hearts as well as in her country Bangladesh. The government clampdown on widespread protests by students has led to over 100 deaths. Sigma’s voice in such a situation would count. A prominent…
#‘Combat the Trafficking of Women in Southasia’#bangladesh#dhaka#history#india#obituary#pakistan#sapan news#sigma huda#south asia#Southasia Peace Action Network
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Our first job. Showtime’s Got Rock!!! 1984
We quit our jobs at MTV Networks on Friday, April 8, 1983 and opened Fred/Alan at 870 7th Avenue, New York City on Monday April 11. MTV was about to hit it’s peak with Michael Jackson’s Thriller video at the end of the year. And we didn’t book our first assignment for almost a year.
Sure, we’d already done a TV show, sort of. MTV and music videos were the hottest thing since The Beatles hit the US in 1964 and everyone wanted in on the action. Even The Playboy Channel, who’d hired us to do “Playboy’s Hot Rocks,” a show of the “uncensored” videos of Duran Duran, David Bowie and the like.
Well the powers that be at Playboy decided the videos just weren’t uncensored enough and without the legal rights re-edited the episodes we turned in with random slugs of naked human video. That was the end of that, we figured the record company lawyers would take care of the rest.
We had no contacts in television so we went about getting some. Over a year after going into business, one of them, Showtime’s Josh Sapan, took mercy on us and threw us a bone.
Showtime was, it’s now safe to say, a bit late to the trend party of music video, given that HBO had been showcasing top rock concerts for years. In mid-1984, they booked the US Festival, a big johnny-come-lately outdoor, multi-day show sponsored by mega-fan Steve Wozniak. Fred/Alan, being the only freelancers around who had rock video experience. No, Fred had never written an MTV promo and Alan had only produced all the animation. But we let Josh have his fantasies and took the job anyway.
The fun parts of the job? Our MTV logo friends Manhattan Design did the illustrations. Alan’s former assistant, Susan Strong, did the shouts.
Alan: “I stole the idea of using Sue Strong from another Sue –Soozin Kazick, I think her name was– who was this super cool assistant at Crawdaddy Magazine when I was writing record reviews for them. I was fascinated by the fact that she had also been one of the girls who cooed "Frankie" before Frankie Crocker's radio show on WBLS [New York], ‘the black experience in sound.’”
And Jerry Carroll, famous then in New York for his “the prices are INSANE!!! at Crazy Eddie’s” commercials, was a charm to work with on the voice over announcing.
Obviously, it went well enough. Fred/Alan entered a decade long, fruitful relationship with Showtime and their recently acquired, Fred’s former home, The Movie Channel. Thanks Josh!
…..
Showtime’s Got ROCK! 1984 Client: Josh Sapan
Agency & Production Company: Fred/Alan, Inc. New York Executive creative directors: Alan Goodman & Fred Seibert Illustration: Manhattan Design Vocal exclamations: Susan Strong Announcer: Jerry Carroll
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Two papers relying on hospital records of COVID-19 patients have been retracted because the company that purportedly analyzed the raw data won’t allow their validity to be independently validated. AP PHOTO/MANU FERNANDEZ
Two elite medical journals retract coronavirus papers over data integrity questions
By Charles Piller, Kelly Servick | June 4, 2020 | ScienceMag.Org
Science’s COVID-19 reporting is supported by the Pulitzer Center.
In the first big research scandal of the COVID-19 era, The Lancet and The New England Journal of Medicine (NEJM) today retracted two high-profile papers after a company declined to make the underlying data for both available for an independent audit, following questions being raised about the research. The Lancet paper, which claimed an antimalarial drug touted by President Donald Trump for treatment of COVID-19 could cause serious harm without helping patients, had had a global impact, halting trials of one of the drugs by the World Health Organization (WHO) and others.
Three authors on the Lancet paper requested the retraction, after initiating an independent review of the raw hospital patient data summarized and provided by Surgisphere, a small Chicago-based company operated by Sapan Desai, the fourth author of the study. Desai had previously said he and his co-authors—cardiac surgeon Mandeep Mehra of Harvard University and Brigham and Women's Hospital, Frank Ruschitzka of University Hospital Zürich, and Amit Patel, an adjunct faculty member at the University of Utah—were getting such an audit of the data, but the agreement apparently fell apart.
“Our independent peer reviewers informed us that Surgisphere would not transfer the full dataset, client contracts, and the full ISO audit report to their servers for analysis as such transfer would violate client agreements and confidentiality requirements,” making the outside audit of the data impossible, the three co-authors wrote in the retraction statement. “Based on this development, we can no longer vouch for the veracity of the primary data sources.”
The NEJM study that was retracted had concluded, based on Surgisphere-provided data from hospitals around the world, that taking certain blood pressure drugs, including angiotensin-converting enzyme (ACE) inhibitors, didn’t appear to increase the risk of death among COVID-19 patients, as some researchers had suggested.
NEJM published only a short statement from the paper’s authors, which included Mandeep Mehra, Amit Patel, and Sapan Desai, as well as Srey Ram Kuy of Baylor College of Medicine and Timothy Henry of Christ Hospital in Cincinnati. “Because all the authors were not granted access to the raw data and the raw data could not be made available to a third-party auditor, we are unable to validate the primary data sources underlying our article,” they wrote, with apology. By including Desai, the note perplexingly suggests he has no access to the raw data generated by his own company.
A third study using Surgispgere data and co-authored by Mehra, Patel, and Desai, among others, was only posted online as a preprint. (It is no longer available.) It reported ivermectin, an antiparasitic drug, dramatically reduced mortality in COVID-19 patients, prompting increased use and government authorization of the drug in several Latin American countries.
The Lancet paper was what brought Surgisphere under scrutiny as it focused on the safety and effectiveness of the malaria drug hydroxychloroquine for COVID-19, which had already become a political and scientific controversy, in large part because of Trump’s embrace of the drug. As soon as the study was published, it came under attack by clinicians, as well as experts in biostatistics and medical ethics who questioned how Surgisphere, a tiny company without much publishing experience in big data analysis, could have collected and analyzed tens of thousands of patient records from hundreds of hospitals—particularly given the complexities of navigating patient confidentiality agreements.
Still, the Lancet study rattled scientists testing hydroxychloroquine in clinical trials because it suggested the drug dramatically increased the death rate of COVID-19 patients. Yesterday, after pausing the hydroxychloroquine arm of one such study in May because of the Lancet results, WHO resumed it. A panel reviewing preliminary data from the trial did not find any obvious evidence of harm to patients.
Desai, a vascular surgeon, entrepreneur, and science-fiction writer, declined requests for comment on the retractions. He said earlier that his artificial intelligence software was able to tease out reliable meaning from the multitude of disparate records.
In a personal statement, Mehra said he connected with Desai through a co-author, and that he personally reviewed the Surgisphere analyses for both the Lancet and NEJM papers. “When discrepancies in the data started to arise, I and the remaining co-authors immediately asked for a reanalysis from Surgisphere and then proactively contracted Medical Technology & Practice Patterns Institute to conduct an independent peer review,” Mehra said. But because Surgisphere would not transfer the primary data to the Bethesda, Maryland, institute, “I no longer have confidence in the origination and veracity of the data, nor the findings they have led to.”
Mehra conceded that in the rush to publish during the COVID-19 crisis, “I did not do enough to ensure that the data source was appropriate for this use. For that, and for all the disruptions—both directly and indirectly—I am truly sorry.”
Mehra is widely viewed as “one of the stars of the field,” says Daniel Goldstein, a cardiothoracic surgeon at the Albert Einstein College of Medicine who has collaborated with Mehra on several studies. “He is as straight an arrow as you can find,” Goldstein says. “I think he maybe was too trusting of this company, because [with] the amount of data that this database gave, it’s hard to believe someone would manipulate it.”
Patel and Ruschitzka did not respond to requests for comment.
Leigh Turner, a bioethicist at the University of Minnesota, Twin Cities, calls the retractions “unnerving and disturbing.” He said the Surgisphere case raises a bigger question about how much access to key data each author and each journal should require. “The less access they have, the greater the chances that there will be errors, data fabrication, or outright fraud.”
The retractions also show that outcry over the accuracy of a flood of COVID-19 preprints, which are not peer reviewed, is only one problem. A lack of rigor in the rush to publish has also reached “elite journals at the top of the academic pyramid.”
Turner said that by publishing only the author retraction statements, The Lancet and NEJM “didn’t show any self-reflection, any introspection. They should have looked at what might have gone wrong” in their own editorial process.
Calls for an outside look at the journals’ action have begun. In a statement, pyschologist Chis Chambers of Cardiff University, a member of the UK Reproducibility Network Steering Group, said: “It is right that these articles were retracted. However, the failure to resolve such basic concerns about the data during the course of normal peer review raises serious questions about the standard of editing at the Lancet and NEJM — ostensibly two of the world’s most prestigious medical journals. If these journals take issues of reproducibility and scientific integrity as seriously as they claim, then they should forthwith submit themselves and their internal review processes to an independent inquiry.”
Two simultaneous retractions in marquee medical journals may be jaw-dropping, but the disappearance of the preprint on ivermectin based on Surgisphere data deserves attention as well, says Carlos Chaccour of the Barcelona Institute for Global Health, who, along with two colleagues, raised questions about those data in a 29 May blog post. (Chaccour has archived the now-vanished manuscript, posted on preprint server SSRN on 19 April, on his institute’s website, along with an earlier version from the same authors that was posted on 6 April.)
The preprint helped make the drug all the rage in South America. Just last week, a doctor cited the study and its reported dramatic effect on mortality in a news show in Chile. “The ivermectin story has gone almost unnoticed. There’s no retraction letter—it was never published,” Chaccour says. “But its ghost lives on in Latin America.”
For Steven Tong, an infectious disease physician at the Doherty Institute in Melbourne, Australia, and an investigator on a hydroxychloroquine trial—the AustralaSian COVID-19 Trial (ASCOT)—which paused last week in response to the Lancet results, the retractions have produced “a mix of frustration and anger … [and] a feeling that our system in research has let us all down, from the authors of the papers, obviously, thorough to the peer reviewers and up to the journal editors. They’ve all done a great disservice to the research world.”
ASCOT, which hadn’t started recruiting patients yet, announced today it would start back up. The trial’s institutional review board has requested the investigators add a statement to the patient consent form describing the recent issues around the publication and retraction. “I think that’s a very fair request, and probably something that patients will ask,” Tong says.
— With reporting by Martin Enserink
— Charles Piller is a contributing correspondent based in Oakland, California.
— Kelly Servick is a staff writer at Science.
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The Walking Dead Season 11 to Begin Filming in October
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For the first time since the show debuted in 2010, The Walking Dead will miss its usual October premiere date. Delays caused by the Covid-19 pandemic have forced AMC to push back the premiere of The Walking Dead season 11 to 2021.
In the new season’s place, AMC will instead air the season 10 finale, the episode titled “A Certain Doom,” on Oct. 4, followed by six “extra” season 10 episodes in early 2021. At the moment, it’s unclear what exactly those six new episodes will be about, although the fact that they’re a continuation of the season suggests that these will be formed out of unused footage from the season 10 shoot. Either way, AMC hasn’t gone into detail about these episodes yet.
Fortunately, the network is already on the move when it comes to season 11, which now has a production start date. AMC CEO Josh Sapan confirmed during an earnings call (via THR) that that filming for The Walking Dead season 11 will begin down on the show’s Georgia set in October, while also stressing that AMC would continue to monitor the situation with the pandemic and adapt as needed.
The new season is set to mark a new era for the show, which has spent the last two years tying up loose ends in the aftermath of the war with Negan and the Saviors as well as exploring a creepy enemy faction known as the Whisperers. With season 10 set to bring Alexandria’s war with the Whisperers to a decisive end, The Walking Dead season 11 will be positioned to explore new territory. Already, the show has teased its next big story, one taken straight from the Robert Kirkman and Charlie Adlard comics, as Eugene, Ezekiel, Yumiko, and Princess continue on a journey that will lead them to a new group they were previously unaware of. Could it be the Commonwealth from the comics? We’ll have to wait until 2021 to find out.
Despite the lack of a new season of The Walking Dead, AMC is still bringing quite a bit of zombie drama to our television sets in October. The new spinoff series, The Walking Dead: World Beyond, is scheduled to premiere right after “A Certain Doom” on Oct. 4. Fear the Walking Dead season 6 will follow on Oct. 11, taking what would have most likely been The Walking Dead season 11’s premiere date.
Sapan also revealed that AMC plans to resume filming for Fear the Walking Dead season 6 in late August down in Texas. This will likely be for episodes of the second half of Fear the Walking Dead season 6 which will presumably run sometime in 2021.
We’ll keep you updated as we learn more about The Walking Dead.
The post The Walking Dead Season 11 to Begin Filming in October appeared first on Den of Geek.
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Two years of Sapan, honouring Lyse Doucet, a music competition, and more
Can you believe Sapan has been at it for two years? That’s the Southasia Peace Action Network, Sapan, ICYMI (‘in case you missed it’ for the uninitiated, helping you get with it, you’re welcome) Excited for the second anniversary event up this Sunday, hosted by the amazing Khushi Kabir in Dhaka, taking forward the legacy of our late friend Kamla Bhasin at Sangat. We’ll review what we’ve done…
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#Activism#democracy#Human rights#journalism#Kamla Bhasin#Khushi Kabir#lyse doucet#music competition#pakistani woman scientist#Politics#sangat#sapan network#sapan news#Southasia
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The Walking Dead Movies And More TV Spin-Offs Planned
Though it might not be drawing in quite the same gigantic ratings as its heyday, The Walking Dead and spin-off Fear The Walking Dead are still big earners for US network AMC in terms of both income and attention. So naturally, the company has big plans to keep the zombie cash cow mooing. As the original series prepares to kick off its ninth season and tackling the challenge of losing lead Andrew Lincoln as Rick Grimes, AMC CEO Josh Sapan has unveiled an ambitious plan to produce new Dead series and potentially movies for at least the next 10 years, with former show-runner turned franchise overseer Scott Gimple driving the efforts.
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