#Samuel Feinberg

[fdmlovesfashion]

CATCHING UP: HAMPTONS Happening 2023

Catching up: It’s mid summer ya’ll! and the Hamptons summer season is in full swing with outdoor events and fundraisers so far. One of our memorable social events this season was the The Annual Hamptons Happening 2023. 300+ guests came to support the Samuel Waxman Cancer Research Foundation’s 19th Annual Hamptons Happening. The fundraising event held at the Bridgehampton estate of hosts Kenneth…

[spacelazarwolf]

in honor of that anon who said jews have done nothing for the world, here’s a non exhaustive list of things we’ve done for the world:

arts, fashion, and lifestyle:

jeans - levi strauss

modern bras - ida rosenthal

sewing machines - isaac merritt singer

modern film industry - carl laemmle (universal pictures), adolph zukor (paramount pictures), william fox (fox film forporation), louis b. mayer (mgm - metro-goldwyn-mayer), harry, sam, albert, and jack warners (warner bros.), steven spielberg, mel brooks, marx brothers

operetta - jacques offenbach

comic books - stan lee

graphic novels - will eisner

teddy bears - morris and rose michtom

influential musicians - irving berlin, stephen sondheim, benny goodman, george gershwin, paul simon, itzhak perlman, leonard bernstein, bob dylan, leonard cohen

artists - mark rothko

actors - elizabeth taylor, jerry lewis, barbara streisand

comedians - lenny bruce, joan rivers, jerry seinfeld

authors - judy blume, tony kushner, allen ginsberg, walter mosley

culture:

esperanto - ludwik lazar zamenhof

feminism - betty friedan, gloria steinem, ruth bader ginsberg

queer and trans rights - larry kramer, harvey milk, leslie feinberg, abby stein, kate bornstein, frank kameny, judith butler

international women's day - clara zetkin

principles of journalizm, statue of liberty, and pulitzer prize - joseph pulitzer

"the new colossus" - emma lazarus

universal declaration of human rights - rene samuel cassin

holocaust remembrance and human rights activism - elie wiesel

workers rights - louis brandeis, rose schneiderman

public health care, women's rights, and children's rights - lillian wald

racial equity - rabbi abraham joshua heschel, julius rosenwald, andrew goodman, michael schwerner

political theory - hannah arendt

disability rights - judith heumann

black lives matter slogan and movement - alicia garza

#metoo movement - jodi kantor

institute of sexology - magnus hirschfeld

technology:

word processing computers - evelyn berezin

facebook - mark zuckerberg

console video game system - ralph henry baer

cell phones - amos edward joel jr., martin cooper

3d - leonard lipton

telephone - philipp reis

fax machines - arthur korn

microphone - emile berliner

gramophone - emile berliner

television - boris rosing

barcodes - norman joseph woodland and bernard silver

secret communication system, which is the foundation of the technology used for wifi - hedy lamarr

three laws of robotics - isaac asimov

cybernetics - norbert wiener

helicopters - emile berliner

BASIC (programming language) - john george kemeny

google - sergey mikhaylovich brin and larry page

VCR - jerome lemelson

fax machine - jerome lemelson

telegraph - samuel finley breese morse

morse code - samuel finley breese morse

bulletproof glass - edouard benedictus

electric motor and electroplating - boris semyonovich jacobi

nuclear powered submarine - hyman george rickover

the internet - paul baran

icq instant messenger - arik vardi, yair goldfinger,, sefi vigiser, amnon amir

color photography - leopold godowsky and leopold mannes

world's first computer - herman goldstine

modern computer architecture - john von neumann

bittorrent - bram cohen

voip internet telephony - alon cohen

data archiving - phil katz, eugene roshal, abraham lempel, jacob ziv

nemeth code - abraham nemeth

holography - dennis gabor

laser - theodor maiman

instant photo sharing online - philippe kahn

first automobile - siegfried samuel marcus

electrical maglev road - boris petrovich weinberg

drip irrigation - simcha blass

ballpoint pen and automatic gearbox - laszlo biro

photo booth - anatol marco josepho

medicine:

pacemakers and defibrillators - louise robinovitch

defibrillators - bernard lown

anti-plague and anti-cholera vaccines - vladimir aronovich khavkin

polio vaccine - jonas salk

test for diagnosis of syphilis - august paul von wasserman

test for typhoid fever - ferdinand widal

penicillin - ernst boris chain

pregnancy test - barnhard zondek

antiretroviral drug to treat aids and fight rejection in organ transplants - gertrude elion

discovery of hepatitis c virus - harvey alter

chemotherapy - paul ehrlich

discovery of prions - stanley prusiner

psychoanalysis - sigmund freud

rubber condoms - julius fromm

birth control pill - gregory goodwin pincus

asorbic acid (vitamin c) - tadeusz reichstein

blood groups and rh blood factor - karl landsteiner

acyclovir (treatment for infections caused by herpes virus) - gertrude elion

vitamins - caismir funk

technique for measuring blood insulin levils - rosalyn sussman yalow

antigen for hepatitus - baruch samuel blumberg

a bone fusion technique - gavriil abramovich ilizarov

homeopathy - christian friedrich samuel hahnemann

aspirin - arthur ernst eichengrun

science:

theory of relativity - albert einstein

theory of the electromagnetic field - james maxwell

quantum mechanics - max born, gustav ludwig hertz

quantum theory of gravity - matvei bronstein

microbiology - ferdinand julius cohn

neuropsychology - alexander romanovich luria

counters for x-rays and gamma rays - robert hofstadter

genetic engineering - paul berg

discovery of the antiproton - emilio gino segre

discovery of cosmic microwave background radiation - arno allan penzias

discovery of the accelerating expansion of the universe - adam riess and saul merlmutter

discovery that black hole formation is a robust prediction of the general theory of relativity - roger penrose

discovery of a supermassive compact object at the center of the milky way - andrea ghez

modern cosmology and the big bang theory - alexander alexandrovich friedmann

stainless steel - hans goldschmidt

gas powered vehicles

interferometer - albert abraham michelson

discovery of the source of energy production in stars - hans albrecht bethe

proved poincare conjecture - grigori yakovlevich perelman

biochemistry - otto fritz meyerhof

electron-positron collider - bruno touschek

[lesboevils]

with pride month approaching and my old archival links post being broken into several annoying sections. here are some useful starting places on lgbt history.

disclaimer: most of this has to do with usamerican history / are in english my apologies, this is just what i had on hand. if you have more please feel free to add them or dm them to me.

the act up oral history project

the lesbian herstory archives

the transgender archives of the university of victoria

the digital transgender archives

glbt historical society

lgbtq digital collaboratory

anything that moves

the bisexual manifesto (1990)

samuel proctor oral history project

a full master post of lesile feinberg's works (stone butch blues included ) by @genderoutlaws

the queer zine archive

dyke march compilation

paris is burning ( documentary )

how to survive a plague ( documentary )

united in anger: a history of ACT UP ( documentary )

screaming queens ( documentary )

the celluloid closet ( documentary )

one institute

audre lorde's poetry collection

aqurives

bi women's quarterly (1/2)

[blindfoldlove]

Books I’ve consumed so far in 2024:

The Order of Time by Carlo Rovelli

I Contain Multitudes: The Microbes Within Us and a Grander View of Life by Ed Yong

Something Deeply Hidden by Sean Carroll

How to Read Nature: An Expert’s Guide to Discovering the Outdoors You Never Noticed by Qarie Marshall

Helgoland: Making Sense of the Quantum Revolution by Carlo Rovelli

The World According to Physics by Jim Al-Khalili

How Not To Kill Yourself: A Portrait of the Suicidal Mind by Clancy Martin

How Far the Light Reaches: A Life in Ten Sea Creatures by Sabrina Imbler

A Series of Fortunate Events: Chance and the Making of the Planet by Sean B. Carroll

Listen: On Music, Sound and Us by Michel Faber

The Art of Communicating by Thich Nhat Hanh

I am a Strange Loop by Douglas R. Hofstadter

Transgender Warriors: Making History from Joan of Arc to Dennis Rodman by Leslie Feinberg

Spectrums: Autistic Transgender People in Their Own Words by Maxfield Sparrow

All the Flowers Kneeling by Paul Tran

Supporting Transgender Autistic Youth and Adults by Finn V. Gratton, LMFT, LPCC

Nisa by Marjorie Shostak

Determined: A Science of Life Without Free Will by Robert M. Sapolsky

21 Lessons for the 21st History by Yuval Harrari

The Book Of Secrets by Deepak Chopra

The Joy of Science by Jim Al-Khalili

The Rock Warriors Way by Arno IIgner

The Pursuit of Endurance by Jennifer Pharr Davis

Quantum Mechanics, Technology, Consciousness and the Multiverse by Martin Ettington

Born to Run by Christopher McDougall

Connecting with the Autism Spectrum by Casey “Remrov” Vormer

Light Falls: Space, Time, and an Obsession with Einstein by Brian Greene

A Walk In the Woods by Bill Bryson

10 Days in Physics that Shook the World by Brian Clegg

On Being a Therapist by Jeffrey Kottler

Atlas of the Heart: Mapping Meaningful Connection and the language of the human experience by Brene Brown

What do you really want? By Cayla Craft

The Peaceful Warrior by Dan Millman

How to Write an Autobiographical Novel by Alexander Chee

Chemistry for Breakfast by Dr. Mai Thi Nguyen-Kim

The Creative Act: A Way of Being by Rick Rubin

A Molecule Away from Madness by Sara Manning Peskin

Quantum Wonder: How the Tiny Drives Our Immense Reality by Carl AL-Khalili

Building a Life Worth Living by Marsha Linehan

How to Know a Person: The Art of Seeing Others Deeply by David Brooks

Speed Reading by Kam Knight

Being You: A New Science of Consciousness by Anil Seth

You Are Not an Imposter by Coline Monsarrat

You are the Placebo by Dr. Joe Dispenza

Welcome to the O.C.: The Oral History by Alan Sepinwall

Heartbreak: A Personal and Scientific Journey by Florence Williams

DBT Made Simple: A Step-by-Step Guide to Dialectical Behavior Therapy by Sheri Van Dijk MSW

Move on Motherf*cker: Live, Laugh, and Let Sh*t Go by Jodie Eckleberry-Hunt, Emma Bryne PhD

Cognitive Behavioral Therapy: Real and proven strategies for managing anxiety by Charlie Norman

CBT Workbook: 7 Strategies to Overcome Anxiety, Depression, Anger, Panic, Worry, Intrusive Thoughts by Mind Change Academy

Dialectical Behavior Therapy: A comprehensive guide to DBT and using Behavior Therapy to Manage Borderline Personality Disorder by Christopher Rance

Somatic Psychotherapy: A Comprehensive Guide to Theoretical and Practical Considerations by Hale Boyd

Dialectical Behavior Therapy: Regulate Emotions, Panic, Anger. Guide for BPD by Dustin Drig

How Confidence Works: The new science of self belief by Ian Robertson

Fear: Essential Wisdom for Getting Through the Storm by Thich Nhat Hanh

The God Equation by Michio Kaku

Dialectical Behavior Therapy by Cindy Crosby

Brief Answers to the Big Questions by Stephen Hawking

Quantum: A Guide for the Perplexed by Jim Al-Khalili

Zen and the Art of Saving the Planet by Thich Nhat Hanh

Einstein in Time and Space: A Life in 99 Particles by Samuel Graydon

Reality is Not What It Seems by Carlo Rovelli

Resurrecting the Body, Reinventing the Soul by Deepak Chopra

A Brief History of Intelligence by Max Bennett

What the Future Looks like by Jim Al-Khalil

Retirement 101: From 401(k) Plans to Social Security Benefits to Asset Management by Michele Cagan

Still the Mind by Alan Watts

Anchor System Thinking by A.I. Shoukry

Finance Basics by Harvard Business Review

The Power of Now by Eckhart Tolle

A Brief History of Earth by Andrew Knoll

The Physics Book by DK

Investing for Beginners by David Cohne

The 48 Laws of Power by Robert Greene

Drink? The New Science of Alcohol and your Health by Professor David Nutt

Unique: The New Science of Human Individuality by David Linden

Psychedelics by Professor David Nutt

What do you need? By Lauren Wesley Wilson

Can’t Hurt Me by David Goggins

Endure by Cameron Hanes

Being Peace by Thich Nhat Hanh

Die with Zero: Getting all you can with your money and your life by Bill Perkins

How Humans Evolved by Robert Boyd and Joan Silk

No Bad Parts by Richard C. Schwartz,PHD

The Matter of Everything: How Curiosity, Physics, and Improbable Experiments Changed the World by Suzie Sheehy

The Radium Girls by Kate Moore

Bumpin: A Modern Guide to Pregnancy by Leslie Schrock

Choose Strong by Sally McRae

Outgrowing God by Richard Dawkins

Can We Talk about Israel? By Daniel Sokatch

Black Holes and Baby Universes and Other Essays by Stephen Hawking

Hal Koerner’s Field Guide to Ultra Running by Hal Koerner

The Science and Art of Running by Cooper Barton

Eat and Run: My Unlikely Journey to Ultramarathon Greatness by Scott Jurek

North: Finding my Way While Running the Appalachian Trail by Scott Jurek & Jenny Jurek

7 Habits of Highly Effective People by Stephen Covey

Securities Industries Essentials by Kaplan

Above the Clouds by Kilian Jornet

What is Life? by Paul Nurse

What I Know For Sure by Oprah Winfrey

A New Earth by Eckhart Tolle

Mastering Logical Fallacies by Michael Withey

This is why you Dream by Rahul Jandial,MD,PHD

The Tao of Running by Gary Dudney

Astrophysics for People in a Hurry by Neil DeGrasse Tyson

The Magic of Reality by Richard Dawkins

Parallel Worlds: A Journey through Creation, Higher Dimensions and the Future of the Cosmos by Michio Kaku

Dance of the Photons by Anton Zelinger

Quantum Body by Deepak Chopra

The Heart of Understanding by Thich Nhat Hanh

Annuity 360 Learn All You Need to Know About Annuities by Ford Strokes

Quantum Entanglement by Jed Brody

Relationships by Ram Dass

The Way of Zen by Alan Watts

Ultimate Confidence by Ralf Aabot

101 Essays that will Change the Way You Think by Brianna Wiest

The Science of Happiness by Brendan Kelly

Fighting for our Friendships by Danielle Bayard Jackson

One Day My Soul Just Opened Up by Iyanla Vanzant

K2: Life and Death on the World’s Most Dangerous Mountain by Ed Viesturs and David Roberts

Know that I Am by Eckhart Tolle

Girls Like Us by Sheila Weller

Love Sense: The Revolutionary New Science of Romantic Relationships by Dr. Sue Johnson

Girls that Invest by Simran Kaur

Slow Productivity by Cal Newport

Greenlights by Matthew McConaughey

Stillness Speaks by Eckhart Tolle

Retroactive Jealousy by Vincenzo Venezia

Right Thing, Right Now by Ryan Holiday

The Best American Essays 2022 by Alexander Chee & Robert Atwan

Talking to Strangers by Malcolm Gladwell

Insecure in love by Leslie Becker-Phelps PHD

Codependent No More by Melody Beattie

Be Here Now by Ram Dass

Reality, Art, and Illusion by Alan Watts

Thinking Fast and Slow by Daniel Kahneman

We Will be Jaguars by Nemonte Nenquimo

The Artist’s Way by Julia Cameron

Rising Strong: How the Ability to Reset Transforms the Way We Live, Love, Parent, and Lead by Brene Brown

Bird by Bird by Anne Lamott

The War of Art by Steven Pressfield

Zen Mind, Beginner’s Mind by Shunryu Suzuki

The Secret Lives of Booksellers and Librarians by James Patterson and Matt Everymann

Gender Queer by Maia Kobabe

Series 7 by Kaplan

What Every Therapist Ought to Know: Attachment, Arousal Regulation, and Clinical Techniques in Clinical Therapy by Stan Tatkin, Psyd,MFT

Mating in Captivity by Esther Perel

Touching a Nerve: Our Brain, Our Selves by Patricia Churchland

Fundamentals: Ten Keys to Reality by Frank Wilczek

Creativity, Inc. ( The expanded edition)by Ed Catmull and Amy Wallace

Bang Crunch Stories by Neil Smith

There are places in the world where rules are less important than kindness and other thoughts in physics, philosophy, and the World by Carlo Rovelli

Let it go by chelene knight

Waters of the world: the stories of the scientists who unraveled the mysteries of the oceans, atmosphere, and Ice Sheets by Sarah Dry

List of Books I Consumed in 2023:

The Last climb by David Breashears, Audrey Selkeld, and Audry Salkend

What is Life by Schrodinger

A Brief History of Time by Stephen Hawking

Beyond Feeling: A Guide to Critical Thinking by Vincent Ryan Ruggiero

Furniture by Kevin Sheetz

A Short History of Nearly Everything by Bill Bryson

Relativity by Albert Einstein

Tao Te Ching by Lao Tzu

An Immense World by Ed Yong

Quantum Supremacy by Michio Kaku

White Holes by Carlo Rovelli

A Separate Reality by Carlos Castaneda

Outlive by Peter Attia

Until the End of Time by Brian Greene

Tribe by Sebastian Junger

Ghosts of Everest by Jochen Hemmleb

Attached by Amir Levine and Rachel Heller

Mind and Matter by Schrodinger

Wired for Love by Stan Tatkin

Grit by Angela Duckworth

The Subtle Art of Not Giving a fuck by Mark Manson

Metamorphosis by Franz Kafka

The Ethical Slut by Janet Hardy and Dossie Easton

Meditations by Marcus Aurelius

The Power of Myth by Joseph Campbell

The Fabric of the Cosmos by Brian Greene

The Body Keeps the Score by Bessel Van Der Kolk

Committed by Elizabeth Gilbert

Homo Deus Summary a Brief History of Tomorrow by Yuval Harari

Alone on the Wall by Alex Honnold

Why we Believe in God (s): A Concise Guide to the Science of Faith by J. Anderson Thomson

Physics and Philosophy: The Revolution of Modern Science by Werner Heisenberg

The Tao of Physics by Fritjof Chopra

Sacred Woman by Queen Afja

Everest: The West Ridge by Thomas Hornbein

Tracks by Robyn Davidson

The Ink Dark Moon by Ono no Komachi and Izumi Shikoku

Einstein by Walter Isaacson

Learned Optimism by Martin Seligman

[lesser-known-composers]

Anatoly Alexandrov (1888-1982) - Recollections (5 pieces) for Piano Op.110

00:00 Prelude - In memoriam Samuel Feinberg 02:18 Tender Image - In Memoriam Alexander Scriabin 03:50 Etude - In Memoriam Sergei Rachmaninov 08:31 Skazka (tale) - In Memoriam Nicolai Medtner 13:44 Epiloque - Self Portrait

Victor Bunin - Piano

[teook]

During the course of conducting research for his landmark study of ftms, for example, Aaron Devor found that over half of his study’s participants reported experiences of intimate gendered abuse as children. Consequently, Devor speculates that “in some cases transsexualism may be an extreme adaptive dissociative response” to trauma. To this end, Devor quotes one of his subjects— a practicing therapist—at length:

I think that serious assault of a young child, especially sexual assault, might cause some children to dissociate and split in a way that establishes a sense of self different from one’s biological sex. . . . I don’t know whether there was a little girl that, fairly early on, through some abuse, disappeared. I don’t know that. But I do know that even if that happened, and I were to try to identify that and work it through, it just seems like the way I’ve lived my life to this point, for forty-one years, says there’s something to be said for that identity.

Like Cvetkovich, who tracks lesbian cultural production in order to elucidate how “trauma can be a foundation for creating counterpublic spheres rather than evacuating them”, Devor and his interlocutors gesture toward the ways in which dissociative responses to trauma might produce inhabitable selves and worlds rather than only destroying them. Indeed, this gesture is made again and again in the transmasculine archive, in the form of narratives that contain scenes of splitting that are hinges in their trajectories, represented as traumatic first encounters with sex difference, failed interpellation into “properly” gendered categories, explicitly transphobic violence, and so on.

While a dissociative poetic is arguably locatable in the writing of transmasculine authors as different in aesthetic, generic, and historical location as Elliott DeLine, Leslie Feinberg, Samuel Ace, Mario Martino, Akwaeke Emezi, Lou Sullivan, Pauli Murray, Jordy Rosenberg, Red Jordan Arobatue, Ely Shipley, and others, it’s especially notable in the work of trans/disabled writer Eli Clare.

— The Terrible We: Thinking with Trans Maladjustment, Cameron Awkward-Rich

[ulkaralakbarova]

Kenneth Feinberg, a powerful D.C. lawyer appointed Special Master of the 9/11 Fund, fights off the cynicism, bureaucracy, and politics associated with administering government funds and, in doing so, discovers what life is worth. Credits: TheMovieDb. Film Cast: Kenneth Feinberg: Michael Keaton Camille Biros: Amy Ryan Charles Wolf: Stanley Tucci Lee Quinn: Tate Donovan Priya Khundi: Shunori Ramanathan Dede Feinberg: Talia Balsam Karen Donato: Laura Benanti Frank Donato: Chris Tardio Darryl Barnes: Ato Blankson-Wood Gloria Toms: Carolyn Mignini John Ashcroft: Victor Slezak Law Student Barron: Logan Hart Law Student Patel: Vihaan Samat Law Student Nguyen: Laura Sohn Bart Cuthbert: Marc Maron Defense Lawyer / William: Alfredo Narciso Plaintiff Lawyer / Gary: Jason Kravits Oliver: Clifton Samuels Older Man (Speaking Spanish): Louis Arcella Attorney 2: Melissa Miller Translator: Ana Isabel Dow Tom Schultz Sr.: Ian Blackman June Schultz: Connie Ray Senator Kennedy: Steve Vinovich Senator Hagel: Bill Winkler Michael Myers: Jeff Biehl Katherine Wolf: Stephanie Heitman 9/11 Mother / Cathy: Deborah Hedwall Blue Collar Man: Tom Bruno Airline Lobbyist: Bradford How Large Fireman: Chris Cardona Richard: David Fierro Laura: Lynne Wintersteller Don: Jon Wenc Jim: Wass Stevens Myrna: Zuzanna Szadkowski Maya: Gayle Rankin Joan: Catherine Curtin Janice: Shernita Anderson Graham Morris: Andy Schneeflock Jose: Brandon Hernandez Carlos: E.R. Ruiz Usher: David Edward Jackson Ruth: Johanna Day Victor: Joseph Ragno Fedex Carrier: Panama Redd Mail Woman: Kay Walbye Fay: Miriam Morales Airline Lobbyist #2: Stephen Reich James: James Ciccone Anthoula: Anthoula Katsimatides Dancer: Jaime Verazin Dancer: Alessandra Marconi Dancer: Lindsey Hailes Dancer: Marc Heitzman Dancer: Jacob ‘Seven Feet’ Melvin Dancer: Jeffery Duffy Meeting Attendee: Billy Lefkowitz Film Crew: Director: Sara Colangelo Producer: Max Borenstein Casting: Kerry Barden Casting: Paul Schnee Original Music Composer: Nico Muhly Costume Design: Mirren Gordon-Crozier Editor: Julia Bloch Production Design: Tommaso Ortino Director of Photography: Pepe Avila del Pino Executive Producer: Nik Bower Executive Producer: Deepak Nayar Executive Producer: Ara Keshishian Executive Producer: Kimberly Fox Unit Production Manager: Charles Miller Executive Producer: Edward Fee Executive Producer: Allen Liu Producer: Marc Butan Producer: Anthony Katagas Producer: Michael Sugar Producer: Brad Dorros Producer: Sean Sorensen Producer: Michael Keaton Set Decoration: Olivia Peebles Makeup Department Head: Ivy Ermert Makeup Artist: Diane Calfee Makeup Artist: Charles Zambrano Visual Effects Supervisor: Eran Dinur Executive Producer: Mary Aloe Set Medic: Bop Tweedie Choreographer: Mark Stuart Production Accountant: James Stayne Producer’s Assistant: Anthony Santos Producer’s Assistant: Laura Pilloni Production Coordinator: Amanda O’Reilly Assistant Production Coordinator: Marilyn Majich Location Assistant: Cenia Hampton Payroll Accountant: Catherine ‘Annie’ Eklund Stand In: Dillon Egyes Production Assistant: Michael Egues Dialogue Coach: Jessica Drake Production Secretary: Dana Darby Post Production Accountant: Nathaniel Carota Script Supervisor: Erika Sanz Corbacho Music Editor: Suzana Peric Music Supervisor: Rupert Hollier Music Supervisor: David Fish Location Manager: Dennis Voskov Assistant Location Manager: Brit Smith Location Scout: Tom Sexton Location Assistant: Lindsey Lambert Location Scout: Eric Jordan Nussbaum Location Assistant: George Marro Location Scout: Sarah Crofts Color Assistant: Ben White Digital Intermediate Editor: Samantha Uber Digital Conform Editor: Josh Perault Finishing Producer: Michael Maida First Assistant Editor: Gordon Holmes Post Production Assistant: Dillon Henry Assistant Editor: Dan Grbic Colorist: Sam Daley Additional Editor: Tariq Anwar Costumer: Kaitie Galligan Assistant Costume Designer: Caitlin Doukas Key Costumer: Sawyer Devuyst Wardrobe Supervisor: Jillian Daidone Set Costumer: Mary Caprari Costume Coordinator: Talia Brody-Barre ADR Voice Casting...

[jcmarchi]

Decorated nanoparticles prevent allergic reactions - Technology Org

New Post has been published on https://thedigitalinsider.com/decorated-nanoparticles-prevent-allergic-reactions-technology-org/

Decorated nanoparticles prevent allergic reactions - Technology Org

Northwestern University researchers have developed the first selective therapy to prevent allergic reactions, ranging in severity from itchy hives and watery eyes to trouble breathing and even death.

A scanning electron microscope image of nanoparticles (colorized in purple) that have successfully entered a mast cell

To develop the new therapy, researchers decorated nanoparticles with antibodies capable of shutting down specific immune cells (called mast cells) responsible for allergic responses. The nanoparticle also carries an allergen corresponding to the patient’s allergy. If a person is allergic to peanuts, for example, then the nanoparticle carries a peanut protein.

In this two-step approach, the allergen engages the precise mast cells responsible for the specific allergy, and then the antibodies shut down only those cells. This highly targeted approach enables the therapy to selectively prevent specific allergies without suppressing the entire immune system.

In a mouse study, the therapy demonstrated 100% success in preventing allergic responses without causing noticeable side effects.

The research was published in the journal Nature Nanotechnology. It marks the first nanotherapy for inhibiting mast cells, thus preventing an allergic response to a specific allergen.

“Currently, there are no methods available to target mast cells specifically,” said Northwestern’s Evan A. Scott, who led the study. “All we have are medications like antihistamines to treat symptoms, and those don’t prevent allergies. They counteract effects of histamines after the mast cells already have been activated. If we had a way to inactivate the mast cells that respond to specific allergens, then we could stop dangerous immune responses in severe situations like anaphylaxis as well as less serious responses like seasonal allergies.”

“The biggest unmet need is in anaphylaxis, which can be life-threatening,” said Northwestern’s Dr. Bruce Bochner, an allergy expert and study co-author. “Certain forms of oral immunotherapy might be helpful in some cases, but we currently don’t have any FDA-approved treatment options that consistently prevent such reactions other than avoiding the offending food or agent. Otherwise, treatments like epinephrine are given to treat severe reactions — not prevent them. Wouldn’t it be great if there was a safe and effective treatment for food allergy that consistently made it possible to reintroduce a food into the diet that you used to have to strictly avoid?”

Scott is the Kay Davis Professor of Biomedical Engineering at Northwestern’s McCormick School of Engineering and a member of the Simpson Querrey Institute for BioNanotechnology, of the International Institute for Nanotechnology and of the Chemistry of Life Processes Institute. Bochner is the Samuel M. Feinberg Emeritus Professor of Medicine (allergy and immunology) at Northwestern University Feinberg School of Medicine. The paper’s first author is Fanfan Du, a postdoctoral fellow in Scott’s laboratory, who worked closely with co-first authors Clayton Rische, a Ph.D. candidate co-mentored by both Bochner and Scott, and Yang Li, a Ph.D. candidate in the Scott lab.

Tricky target

Located in nearly all tissues throughout the human body, mast cells are best known for being primarily responsible for allergic responses. But they also play several other important roles, including regulation of blood flow and fighting parasites. Therefore, fully eliminating mast cells to prevent allergic reactions could be damaging to other useful, healthy responses.

“Although some drugs are under development, there are currently no FDA-approved drugs that inhibit, or eliminate, mast cells,” Bochner said. “This has been difficult mainly because drugs that can affect mast cell activation or survival also target cells other than mast cells, and thus tend to have unwanted side effects due to influences on other cells.”

In previous work, Bochner identified Siglec-6, a unique inhibitory receptor that is highly and selectively found on mast cells. If researchers could target that receptor with an antibody, then they could selectively inhibit mast cells to prevent allergy. But introducing this antibody by itself fell short.

“It was difficult to get a high-enough concentration of the antibody to have an effect,” Scott said. “We wondered if we could enhance this concentration using a nanoparticle. If we could pack a high density of antibodies onto a nanoparticle, then we could make it practical for use.”

Sticking antibodies onto a particle

To pack the antibodies onto a nanoparticle, Scott and his team had to overcome another challenge. For proteins (like antibodies) to stick to a nanoparticle, they typically must form a chemical bond that unfolds (or denatures) the protein, affecting its biological activity. To bypass this challenge, Scott turned to a nanoparticle previously developed in his laboratory.

Unlike more standard nanoparticles that have stable surfaces, Scott’s newly developed nanoparticle comprises dynamic polymer chains, which can independently flip their orientation upon exposure to different solvents and proteins. When put into liquid solutions, the chains orient themselves to achieve favorable electrostatic interactions with water molecules. But when a protein touches the nanoparticle surface, the specific tiny polymer chains at the interface flip their orientations to stably hold onto the protein without covalently bonding to it. Scott’s team also found that water-repelling pockets on protein surfaces were key to the stable interaction.

When binding to surfaces, proteins typically denature, losing their bioactivity. A unique aspect of Scott’s nanoparticles is that they can stably bind enzymes and antibodies while maintaining their 3D structure and biological functions. This means the anti-Siglec-6 antibodies maintained their strong affinity for the mast cell receptors — even when attached to the nanoparticle surfaces.

“This is a uniquely dynamic surface,” Scott said. “Instead of a standard stable surface, it can switch its surface chemistry. It’s made of tiny polymer chains of compounds, which can flip their orientation to maximize favorable interactions with both water and proteins as necessary.”

When Scott’s team mixed the nanoparticles with antibodies, close to 100% of the antibodies successfully attached to the nanoparticles without losing their ability to bind to their specific targets. This resulted in a nanoparticle-based therapy employing surfaces with densely packed and highly controllable amounts of multiple distinct antibodies to target mast cells. 

Selective shut down

In order for someone to become allergic, their mast cells capture and display antibodies, specifically immunoglobulin E (IgE) antibodies, for that specific allergen. This enables the mast cells to recognize — and react to — the same allergen upon re-exposure.

“If you have a peanut allergy and have had a response to peanuts in the past, then your immune cells made IgE antibodies against peanut proteins, and the mast cells collected them,” Scott said. “Now, they are waiting for you to eat another peanut. When you do, they can respond within minutes, and if the response is strong enough, it can result in anaphylaxis.”

To selectively target mast cells to respond to a particular allergen, the researchers designed their therapy to engage only mast cells carrying IgE antibodies for that allergen. The nanoparticle uses a protein allergen to engage with IgE antibodies on the mast cells and then uses an antibody to engage the Siglec-6 receptor to shut down the mast cell’s ability to react. And because only mast cells display Siglec-6 receptors, the nanoparticle cannot bind to other cell types — a strategy that effectively limits side effects.

“You can use any allergen that you want, and you will selectively shut down the response to that allergen,” Scott said. “The allergen would normally activate the mast cell. But at the same time the allergen binds, the antibody on the nanoparticle also engages the inhibitory Siglec-6 receptor. Given these two contradictory signals, the mast cell decides that it shouldn’t activate and should leave that allergen alone. It selectively stops a response to a specific allergen. The beauty of this approach is that it does not require killing or eliminating all the mast cells. And, from a safety standpoint, if the nanoparticle accidentally attaches to the wrong cell type, that cell just won’t respond.”

Preventing anaphylaxis in mice

After demonstrating success in cellular cultures using human tissue-derived mast cells, the researchers moved their therapy into a humanized mouse model. Because mast cells in mice do not have the Siglec-6 receptor, Bochner’s team developed a mouse model with human mast cells in their tissues. The researchers exposed the mice to an allergen and delivered the nanotherapy at the same time.

No mice experienced anaphylactic shock and all survived.

“The simplest way to monitor an allergic response is to track changes in body temperature,” Scott said. “We saw no changes in temperature. There was no response. Also, the mice remained healthy and did not display any outward signs of an allergic reaction.”

“Mouse mast cells do not have Siglec-6 on their surface like in humans, but we got as close as we could for now to actual human studies by testing these nanoparticles in special mice that had human mast cells in their tissues,” Bochner said. “We were able to show that these humanized mice were protected from anaphylaxis.”

Next, the researchers plan to explore their nanotherapy for treating other mast cell-related diseases, including mastocytosis, a rare form of mast cell cancer. They also are investigating approaches to loading drugs inside the nanoparticles to selectively kill mast cells in mastocytosis without injuring other cell types.

Source: Northwestern University

You can offer your link to a page which is relevant to the topic of this post.

[mrdirtybear]

Samuel Feinberg (1890 - 1962) was a Russian and Soviet composer and pianist. Feinberg was the first pianist to perform the complete The Well-Tempered Clavier by Bach in concert in the USSR. He is most remembered today for his complete recording of it, and many other works from the classical and romantic eras. He also composed three piano concertos, a dozen piano sonatas. Recordings exist of him playing his piano Sonatas 1, 2, 9 and 12, as well as fantasias and other works for the instrument. Pianist Tatiana Nikolayeva said that each of his sonatas was a "poem of life". Feinberg has been called "A musical heir to Scriabin", who heard the young pianist play his fourth sonata and praised it highly.

[albert-bierstadt]

Mountain Brook, Albert Bierstadt, 1863, Art Institute of Chicago: American Art

Albert Bierstadt is best remembered for his paintings of the American West, but during his early career, the ambitious artist also created New England landscapes, particularly of the White Mountains, as seen here. When this painting was first exhibited in 1863, critics declared it Bierstadt’s “best work” and praised the artist’s deft contrast of “light and shade,” which brought a heightened realism to the image. Bierstadt’s affinity for the White Mountains mirrored a growing interest in the region as one of America’s premiere tourist attractions. Photographs of the area from the 19th century suggest that Bierstadt utilized landscape elements from the popular tourist site “The Flume” in this imaginary composition. Restricted gift of Mrs. Herbert A. Vance; fund of an anonymous donor; Wesley M. Dixon Jr. Fund and Endowment; Henry Horner Straus and Mr. and Mrs. Frederick G. Wacker Jr. endowment funds; through prior acquisitions of various donors, including Samuel P. Avery Endowment, Mrs. George A. Carpenter, Frederick S. Colburn, Mr. and Mrs. Stanley Feinberg, Field Museum of Natural History, Mr. and Mrs. Frank Harding, International Minerals and Chemicals Corp., Mr. and Mrs. Ralph Loeff, Mrs. Frank C. Miller, Mahlan D. Moulds, Mrs. Clive Runnells, Mr. and Mrs. Stanley Stone, and the Charles H. and Mary F.S. Worcester Collection Size: 111.8 × 91.4 cm (44 × 36 in.) Medium: Oil on canvas

https://www.artic.edu/artworks/146701/

[aic-american]

Mountain Brook, Albert Bierstadt, 1863, Art Institute of Chicago: American Art

Albert Bierstadt is best remembered for his paintings of the American West, but during his early career, the ambitious artist also created New England landscapes, particularly of the White Mountains, as seen here. When this painting was first exhibited in 1863, critics declared it Bierstadt’s “best work” and praised the artist’s deft contrast of “light and shade,” which brought a heightened realism to the image. Bierstadt’s affinity for the White Mountains mirrored a growing interest in the region as one of America’s premiere tourist attractions. Photographs of the area from the 19th century suggest that Bierstadt utilized landscape elements from the popular tourist site “The Flume” in this imaginary composition. Restricted gift of Mrs. Herbert A. Vance; fund of an anonymous donor; Wesley M. Dixon Jr. Fund and Endowment; Henry Horner Straus and Mr. and Mrs. Frederick G. Wacker Jr. endowment funds; through prior acquisitions of various donors, including Samuel P. Avery Endowment, Mrs. George A. Carpenter, Frederick S. Colburn, Mr. and Mrs. Stanley Feinberg, Field Museum of Natural History, Mr. and Mrs. Frank Harding, International Minerals and Chemicals Corp., Mr. and Mrs. Ralph Loeff, Mrs. Frank C. Miller, Mahlan D. Moulds, Mrs. Clive Runnells, Mr. and Mrs. Stanley Stone, and the Charles H. and Mary F.S. Worcester Collection Size: 111.8 × 91.4 cm (44 × 36 in.) Medium: Oil on canvas

https://www.artic.edu/artworks/146701/

[materialsscienceandengineering]

Synthetic materials mimic living creatures

'Robotic soft matter' bends, rotates and crawls when hit with light

Northwestern University researchers have developed a family of soft materials that imitates living creatures.

When hit with light, the film-thin materials come alive -- bending, rotating and even crawling on surfaces.

Called "robotic soft matter by the Northwestern team," the materials move without complex hardware, hydraulics or electricity. The researchers believe the lifelike materials could carry out many tasks, with potential applications in energy, environmental remediation and advanced medicine.

"We live in an era in which increasingly smarter devices are constantly being developed to help us manage our everyday lives," said Northwestern's Samuel I. Stupp, who led the experimental studies. "The next frontier is in the development of new science that will bring inert materials to life for our benefit -- by designing them to acquire capabilities of living creatures."

The research will be published on June 22 in the journal Nature Materials.

Stupp is the Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering at Northwestern and director of the Simpson Querrey Institute He has appointments in the McCormick School of Engineering, Weinberg College of Arts and Sciences and Feinberg School of Medicine. George Schatz, the Charles E. and Emma H. Morrison Professor of Chemistry in Weinberg, led computer simulations of the materials' lifelike behaviors. Postdoctoral fellow Chuang Li and graduate student Aysenur Iscen, from the Stupp and Schatz laboratories, respectively, are co-first authors of the paper.

Although the moving material seems miraculous, sophisticated science is at play. Its structure comprises nanoscale peptide assemblies that drain water molecules out of the material. An expert in materials chemistry, Stupp linked the peptide arrays to polymer networks designed to be chemically responsive to blue light.

Read more.

[mybeautifulchristianjourney]

How Shall I Give Thee Up?

by Charles L. Feinberg

"When Israel was a child, I loved him, and out of Egypt I called My son. . . . I taught Ephraim to walk, taking them by their arms; but they did not know that I healed them. I drew them with gentle cords, with bands of love, and I was to them as those who take the yoke from their neck. I stooped and fed them. He shall not return to the land of Egypt; but the Assyrian shall be his king, because they refused to repent. And the sword shall slash in his cities, devour his districts, and consume them, because of their own counsels. My people are bent on backsliding from Me. Though they call to the Most High, none at all exalt Him. How can I give you up, Ephraim? How can I hand you over, Israel? How can I make you like Admah? How can I set you like Zeboiim? My heart churns within Me; My sympathy is stirred. I will not execute the fierceness of My anger; I will not again destroy Ephraim. For I am God, and not man, the Holy One in your midst; and I will not come with terror. They shall walk after Yahweh. He will roar like a lion. when He roars, then His sons shall come trembling from the west; they shall come trembling like a bird from Egypt, like a dove from the land of Assyria. And I will let them dwell in their houses, says Yahweh." - Hosea 11:1-11

Such conduct against the living God must be visited with His righteous wrath and condemnation. But God never delights in judgment, which is His strange work, but takes pleasure in mercy and favor. True, Israel is worthy of punishment, but God's love must be reckoned with as well. Therefore, He cries out from the innermost recesses of His blessed being, "How shall I give thee up, Ephraim? How shall I cast thee off, Israel?"

This verse has been said to be the greatest passage in the book. It may well vie for that honor. If God says He loved them from the very beginning, from a child, how much greater must be His love for them after so many centuries of gracious dealings with them? He finds it impossible to give them up, though they have revolted against Him. His love is now in the form of compassion, because in their unworthiness they need His love all the more. How our children as they grow older entwine themselves about our hearts! So did Ephraim about the heart of God. He could not bring Himself to the place where He would cast him off wholly, as He did with Admah and Zeboim, the wicked cities of the plain which were completely overthrown with Sodom and Gomorrah.

Actually, God is saying they are as wicked and guilty as these cities, deserving of the severest punishment, but His love is kindled for them. Let us not forget that God did chasten them for their waywardness, although He could not give them up altogether.

Samuel Rutherford's grand hymn is right: "O Christ, He is the Fountain, the deep, sweet well of love." His love and His compassions are kindled when He thinks of Israel. He is determined that He will not execute the fierceness of His anger; mercy rejoices over judgment. Ephraim will not suffer the same irrevocable fate of the cities of the plain. For the Lord is God and not man, who executes his unappeased wrath under great provocation. God will not enter the city as a foe, as in the days of Sodom.

The reason God's mercy triumphs so signally is the remnant among God's people. They will seek and walk after the Lord (Hos. 3:4-5). Apostasy in Israel, even in the darkest days of her history, is never complete and universal; there is always a remnant among the people. To these godly ones God roars like a lion, His summons to gather His dispersed ones from their dispersion. It will be a voice of majesty and awe that will call the wandering ones back. They, on their part, will come trembling in eagerness and glad anticipation. The place of their origin will be specifically the west, as well as from Egypt and Assyria.

This was not true in the Assyrian or Babylonian exiles, but has been true ever since the dispersion by the Romans. What is meant, then, is a regathering from all the world, as the prophet Isaiah also confirms (Is. 11:11). From all these places they will come flying in haste as a dove (no longer the silly dove of 7:11), to be resettled in their own land by the Lord, never to be uprooted again.

[lesser-known-composers]

Anatoly Alexandrov (1888-1982) - Recollections (5 pieces) for Piano Op.110

00:00 Prelude - In memoriam Samuel Feinberg 02:18 Tender Image - In Memoriam Alexander Scriabin 03:50 Etude - In Memoriam Sergei Rachmaninov 08:31 Skazka (tale) - In Memoriam Nicolai Medtner 13:44 Epiloque - Self Portrait

Victor Bunin - Piano

[aunti-christ-ine]

Curly, Larry, Moe . . . 

 . . . and Shemp. 

Moe Howard = Moses Harry Horwitz (June 19, 1897 – May 4, 1975)        He was named Moe when he was younger and later called himself Harry. 

Larry Fine =  Louis Feinberg (October 5, 1902 – January 24, 1975)        His father, Joseph Feinberg, and mother, Fanny Lieberman, owned a watch-repair and jewelry shop. 

Curly Howard =  Jerome Lester Horwitz (October 22, 1903 – January 18, 1952)        Because he was the youngest, his brothers called him "Babe" to tease him. The name "Babe" stuck with him all his life, although when his elder brother Shemp Howard married Gertrude Frank, who was also nicknamed "Babe," the brothers called him "Curly" to avoid confusion. His full formal Hebrew name was "Yehudah Lev bar Shlomo Natan HaLevi." [4] 

Shemp Howard =  Samuel Horwitz (March 11, 1895 – November 22, 1955)      Shemp’s real first name, Shmuel (after his grandfather), was anglicized to Samuel, and his parents and brothers usually called him Sam. 

 [Source:Wikipedia] 

p.s. @MeTV is showin’ ‘em Saturdays at 6pm ET 

[ulkaralakbarova]

After a lightning bolt zaps a robot named Number 5, the lovable machine starts to think he’s human and escapes the lab. Hot on his trail is his designer, Newton, who hopes to get to Number 5 before the military does. In the meantime, a spunky animal lover mistakes the robot for an alien and takes him in, teaching her new guest about life on Earth. Credits: TheMovieDb. Film Cast: Stephanie Speck: Ally Sheedy Newton Crosby: Steve Guttenberg Ben Jabituya: Fisher Stevens Howard Marner: Austin Pendleton Skroeder: G.W. Bailey Frank: Brian McNamara Number 5 (voice): Tim Blaney Duke: Marvin J. McIntyre Otis: John Garber Mrs. Cepeda: Penny Santon General Washburne: Vernon Weddle Senator Mills: Barbara Tarbuck Howard Marner’s Aide: Tom Lawrence Norman: Fred Slyter Zack: Billy Ray Sharkey Reporter: Robert Krantz Reporter: Jan Speck Barmaid: Marguerite Happy Farmer: Howard Krick Farmer’s Wife: Marjorie Card Hughes Gate Guard: Herb Smith Party Guest: Jack Thompson Party Guest: William Striglos Party Guest: Mary Reckley Party Guest: Shay McLean Party Guest: Eleanor C. Heutschy Frank: Sergio Kato Film Crew: Producer: David Foster Producer: Lawrence Turman Director: John Badham Editor: Frank Morriss Art Direction: Dianne Wager Original Music Composer: David Shire Director of Photography: Nick McLean Second Unit Director: Gregg Champion Scenario Writer: S.S. Wilson Writer: Brent Maddock Location Manager: Mark Indig Casting: Jane Feinberg Script Supervisor: H. Bud Otto Co-Producer: Dennis E. Jones Title Designer: David Oliver Pfeil Casting: Mike Fenton Executive Producer: Mark Damon Set Decoration: Garrett Lewis Associate Producer: Dana Satler Hankins Associate Producer: Gary Foster Title Designer: Wayne Fitzgerald Executive Producer: John W. Hyde Casting: Judy Taylor Production Coordinator: Mary Cay Hollander Unit Production Manager: Steve Perry First Assistant Director: Jerry Ziesmer Second Assistant Director: Bryan Denegal Assistant Art Director: Donald B. Woodruff Camera Operator: Michael D. O’Shea Camera Operator: Steve Bridge First Assistant Camera: Michael A. Chavez Still Photographer: Bruce McBroom Sound Mixer: Willie D. Burton Boom Operator: Marvin E. Lewis Utility Sound: Robert W. Harris Supervising Sound Editor: William L. Manger Supervising Sound Editor: Milton C. Burrow Sound Editor: Richard Burrow Sound Editor: Scott Burrow Sound Editor: Richard Oswald Music Editor: Stan Witt Assistant Sound Editor: Kelly L. Manger Construction Coordinator: Michael Muscarella Construction Foreman: Joseph C. Fama Property Master: Gregg H. Bilson Assistant Property Master: Stan Cockerell Standby Painter: Jerry Gadette Greensman: Philip C. Hurst Makeup Artist: Tom Lucas Hairstylist: Damon Grill Gaffer: Colin J. Campbell Key Grip: Bill Young Dolly Grip: Donald L. Hartley Grip: Johnny London Jr. Leadman: Mark Woods Video Assist Operator: Richmond G. Cogswell Production Illustrator: Martin A. Kline Sound Re-Recording Mixer: Wayne Artman Sound Re-Recording Mixer: Tom E. Dahl Sound Re-Recording Mixer: Tom Beckert Unit Publicist: Vic Heutschy Production Accountant: Jan Garner Negative Cutter: Donah Bassett Stunt Coordinator: Walter Scott Special Effects Coordinator: Chuck Gaspar Stunts: Freddie Hice Stunts: Christine Anne Baur Stunts: Brad Bovee Stunts: Vince Deadrick Sr. Stunts: Marguerite Happy Stunts: Clifford Happy Stunts: Danny Costa Stunts: Bob Harris Stunts: Loren Janes Stunts: Robert Jauregui Stunts: Ben Scott Stunts: John-Clay Scott Stunts: Sasha Jenson Stunts: Ted White Stunts: R.L. Tolbert Second Assistant Camera: Robert Samuels Movie Reviews: