#Polyunsaturated Fatty Acid (PUFAs) Market

[ashimbisresearch]

Get Insights with Detailed Free Sample Report on Asia-Pacific Polyunsaturated Fatty Acids Industry.

[delicatemagazinedreamer]

Global Polyunsaturated Fatty Acid (PUFAs) Market Is Estimated To Witness High Growth Owing To Increasing Awareness About Health Benefits of PUFAs

The global Polyunsaturated Fatty Acid (PUFAs) Market is estimated to be valued at US$ 5.89 Bn in 2022 and is expected to exhibit a CAGR of 8.0% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. A) Market Overview: Polyunsaturated Fatty Acids (PUFAs) are essential fatty acids that play a vital role in maintaining overall health. They have several health benefits, including reducing inflammation, improving heart health, boosting brain function, and supporting healthy skin. PUFAs cannot be produced by the body and need to be obtained from dietary sources or supplements. The increasing awareness about the health benefits of PUFAs among consumers is driving the growth of the global PUFAs market. B) Market Key Trends: One key trend driving the PUFAs market is the growing demand for omega-3 fatty acids. Omega-3 fatty acids are a type of PUFAs that are widely recognized for their numerous health benefits. They have been shown to reduce the risk of heart disease, support brain health, alleviate symptoms of arthritis, and promote healthy skin. As a result, there has been a surge in demand for omega-3 fatty acids from various sectors, including food and beverages, pharmaceuticals, and dietary supplements. For example, omega-3 enriched functional foods and beverages are becoming increasingly popular among health-conscious consumers. C) PEST Analysis: Political: There are no major political factors that directly impact the PUFAs market. However, government regulations and policies regarding food safety and labeling requirements can affect the production and marketing of PUFAs. Economic: The economic factors influencing the PUFAs market include GDP growth, disposable income, and consumer spending patterns. A strong economy and increasing disposable income levels can drive the demand for PUFAs. Social: The growing health consciousness among consumers is a significant social factor driving the Polyunsaturated Fatty Acid (PUFAs) Market Demand. Consumers are becoming more aware of the importance of a healthy diet and are actively seeking out functional foods and supplements that contain PUFAs. Technological: Advancements in technology have made it possible to efficiently extract and purify PUFAs from various sources like fish oil, algae, and krill oil. These technological innovations have significantly contributed to the growth of the PUFAs market by expanding the availability of high-quality PUFAs. D) Key Takeaways: - The global Polyunsaturated Fatty Acid (PUFAs) market is expected to witness high growth, exhibiting a CAGR of 8.0% over the forecast period, due to increasing awareness about the health benefits of PUFAs. - North America is expected to dominate the PUFAs market, driven by a well-established dietary supplements industry and increasing demand for functional food and beverages. - Key players operating in the global PUFAs market include Koninklijke DSM N.V, BASF SE, Croda International PLC, Enzymotec Ltd., Omega Protein Corporation, Aker Bio Marine AS, Polaris Nutritional Lipids, FMC Corporation, Cargill Incorporated, and GlaxoSmithKline plc. These companies are focusing on research and development activities to launch innovative PUFAs products in the market. In conclusion, the global Polyunsaturated Fatty Acid (PUFAs) market is experiencing significant growth due to increasing consumer awareness about the health benefits of PUFAs. The demand for omega-3 fatty acids, in particular, is driving market growth. Factors such as technological advancements and a growing focus on health and wellness are also contributing to the expansion of the PUFAs market. With key players actively investing in research and development, the market is expected to witness continued growth in the coming years.

[dutifullycoralcollector]

Latest Research Report on Omega-3 PUFA Market by Application, Industry Share, End User, Opportunity Analysis 2030 with top players

Omega-3 PUFA (polyunsaturated fatty acids) market refers to the market for products containing omega-3 fatty acids, which are essential nutrients for human health. Omega-3 fatty acids are a type of unsaturated fatty acid that cannot be produced by the body and must be obtained from dietary sources.

The global omega-3 PUFA market is driven by increasing consumer awareness of the health benefits of omega-3 fatty acids, such as their potential to reduce the risk of heart disease, lower blood pressure, and improve brain function. The market includes a range of products such as supplements, functional foods, and pharmaceuticals.

For Download Free Sample Link Here:-https://www.marketinforeports.com/Market-Reports/Request-Sample/487576

The omega-3 PUFA market is segmented by source (marine, plant-based), application (supplements, functional foods and beverages, pharmaceuticals, infant formula, pet food), and region. The marine-based omega-3 PUFA segment is expected to hold the largest market share due to the high concentration of EPA and DHA, the two main types of omega-3 fatty acids that are most beneficial to human health, in fish oil.

Key players in the omega-3 PUFA market include BASF SE, Koninklijke DSM N.V., Croda International Plc, Omega Protein Corporation, Cargill, and Corbion N.V. The market is competitive, with companies focusing on product innovation and development, as well as mergers and acquisitions to increase their market share.

[crimsonpublishersnutrition]

How Healthy are Commercial Cream and Butter-Creams? Assessment According to their Fatty Acid Composition, Cholesterol Contents, Atherogenic and Thrombogenic Indices

In this study, cream and butter-cream samples from dairy markets were analyzed for their fatty acid compositions and cholesterol concentrations. Their fat contents were also identified to characterize the nutritional quality. The Saturated Fatty Acids (SFA) contents of cream samples were higher when compared to butter-cream models. The average Polyunsaturated Fatty Acids (PUFA) and cholesterol contents of butter-cream samples are relatively higher than the average PUFA and cholesterol contents of cream samples. Atherogenic and thrombogenic indices of samples were calculated to account for the various impacts that specific fatty acids may have on human health.

Read more about this article: https://crimsonpublishers.com/ntnf/fulltext/NTNF.000648.php

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[bhavanameti]

Nannochloropsis-Derived Lipids (Fatty Acids) Market Worth $4.20 Million by 2028

Meticulous Research® –a leading global market research company published a research report titled “Nannochloropsis-Derived Lipids (Fatty Acids) Market by Application (Human Nutrition (Health Supplements & Nutraceuticals, Pharmaceuticals, Other Human Nutritional Applications), Animal Nutrition, and Other Applications) - Global Forecast to 2028.”

In the latest Meticulous Research® report, the Nannochloropsis-Derived Lipids (Fatty Acids) Market is projected to grow at a CAGR of 8.5% from 2021 to 2028, reaching $4.20 million by 2028. The market's expansion is fueled by increasing awareness of the health benefits of omega-3 Polyunsaturated Fatty Acids (PUFAs), rising demand for functional food products, and the prevalence of diabetes and obesity. Moreover, the demand for algae oil-based biofuel and omega-3 from the pharmaceutical industry present promising opportunities for manufacturers of Nannochloropsis-derived lipid (fatty acids). However, the complex production process poses a challenge to market growth.

The global Nannochloropsis-Derived Lipids (Fatty Acids) Market is segmented by application, with human nutrition expected to dominate in 2021. This dominance is driven by the increasing demand for algae oil in nutraceuticals, dietary supplements, infant formula, and functional foods. Within human nutrition, the health supplements & nutraceuticals segment is anticipated to hold the largest share, fueled by the growing health supplements and nutraceutical industry."

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Geographically, Europe is projected to lead the market in 2021, followed by North America and Asia-Pacific. The growth in Europe is attributed to increasing consumption of health and wellness products and the presence of key Nannochloropsis biomass suppliers. The report also profiles key players in the market, including Arizona Algae Products, LLC, Lyxia Corporation, Shaivaa Algaetech LLP, and iwi Life.

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Meticulous Research® Email- sales@meticulousresearch.com Contact Sales- +1-646-781-8004 Connect with us on LinkedIn- https://www.linkedin.com/company/meticulous-research

[foodresearchlab]

Global Market Analysis of Fish Oil – Foodresearchlab

Fish oil is a commonly consumed supplement, and the Food Research Lab delves in to the factors affecting the growth of fish oil market. Fish oil is derived from fatty fish like sardine, herring and salmon and is rich in Polyunsaturated Fatty Acids (PUFAs). There are three categories of PUFAs: oleic acid, linoleic acid and alpha-linolenic acid (ALA) 

[neuherbsblog]

Chia seeds are a great way to add a healthy dose of fiber to your diet. They’re also a good source of protein, omega-3 fatty acids, and vitamins.

Before purchasing, look for a brand that sources chia seeds sustainably from small farmers. This ensures that you’re getting the best possible quality.

The price of 1kg chia seeds cost falls under 457 - 700 as per the brand

Neuherbs Organic Raw Unroasted Chia Seeds for weight loss management- Seed for eating with High protein and fiber (1 kg)

Chia seeds are tiny black coloured seeds that are full of enormous nutrition and health benefits. They are loaded with Omega-3, dietary fibre, protein and calcium which boost immunity and enhance health. They are a versatile food item and can be added to smoothies, juices, milkshakes, puddings or even yoghurt and oatmeal.

Adding chia seeds to your diet can help with weight loss. They contain protein and fiber that can aid in a weight loss program by reducing appetite and increasing feelings of fullness. They also contain polyunsaturated fatty acids (PUFAs), which are important for health.

They can help lower triglycerides and LDL cholesterol and increase HDL cholesterol, which may improve heart health. They may also help to manage blood sugar levels in people with diabetes.

The antioxidants, minerals, and fiber in chia seeds may help promote healthy blood pressure and heart health, and improve insulin sensitivity. They can also help to control satiety, reduce appetite, and decrease cravings for high-calorie foods.

They are a great addition to a healthy diet, and you can find many recipes online that incorporate chia seeds. They are also a source of Omega-3 fatty acids, iron, and calcium.

These are raw, natural, and organic chia seeds that have been used in Mexico since ancient times for several health benefits. They are packed with fiber and a variety of other nutrients, such as protein, vitamins, minerals, and antioxidants.

You can mix & soak chia seeds in water or other liquids to turn them into a gel-like substance, which makes them useful for thickening desserts. You can also add chia seeds to salads and yogurt to make them more nutritious.

Neuherbs brings to you these chia seeds that are produced by nature and harvested organically for a healthier you. They are an excellent source of fibre and a number of other nutrients, including protein, omega 3, antioxidants, and vitamins. Adding them to your regular or favourite meals is an easy way to improve the nutrition quality of your food and to gain various health advantages.

Neuherbs Organic Chia Seeds are raw

Aside from being an excellent source of fibre and good source of omega 3, it also contains several other nutrients like protein, antioxidants, vitamins and minerals. The best part is that it's easy to incorporate into your daily diet.

Neuherbs brings you the good stuff and has a wide range of chia seeds to suit your budget and needs. Their chia seeds are raw and unroasted so you don't have to worry about pesticides or fungi.

In addition to their chia seed line, they offer a range of other products to keep you looking and feeling healthy. From weight management supplements, to skin care, to bone health and blood sugar level solutions. The company's motto is "feel better, look better, get more out of life" and they deliver the goods through a network of certified stores in 164 countries worldwide. The company is also known for its enviable customer service. You can contact their knowledgeable team through phone, live chat or email. You can also read their product reviews on portals such as Trustpilot.

Neuherbs Organic Chia Seeds are unroasted

When it comes to buying chia seeds, there are several brands that are available in the market. However, it is important to pick the right one to get the best benefits. This can help you in achieving your weight loss goals and improve your health.

The Neuherbs Organic Chia Seeds are unroasted and packed with protein, fiber, calcium & other minerals. These nutrients are essential for your overall wellbeing and help in keeping you fit and healthy. These seeds also aid in preventing a number of chronic diseases such as high blood pressure, diabetes, arthritis, etc.

These seeds are also rich in Omega-3 fatty acids, which is important for improving heart health and reducing inflammation. This also helps in maintaining a healthy immune system.

Apart from this, these chia seeds are packed with antioxidants that prevent free radicals and reduce the signs of ageing. They are also a good source of fibre, which keeps you full and satisfied for a long time.

This product is certified organic and made from the highest quality ingredients. It is also free from pesticides and harmful chemicals.

Another benefit of these chia seeds is that they are vegan-friendly and gluten-free. They are rich in Omega-3 fatty acids, fibre, protein, and minerals. They are also low in calories, which makes them an ideal choice for a healthy diet.

This is a premium quality product that is made in India with utmost care and attention. This ensures that the chia seeds are pure and organic. The packaging is airtight, which ensures that the chia seeds are fresh for a longer period of time. They are also packaged in a zip-lock bag, which is easy to carry and store.

Neuherbs Organic Chia Seeds are gluten-free

Whether you're a gluten-free eater or just prefer to keep things simple, Neuherbs Organic Chia Seeds are a great way to add chia to your diet. They're packed with healthful nutrients and can be used to make many different types of treats.

They are a good source of Omega-3 fatty acids, protein, dietary fiber, and calcium. They also contain antioxidants that help protect the body against free radical damage.

In addition, they are a great source of magnesium and calcium, which helps maintain strong bones and teeth. They can be a great addition to your diet for weight loss and can also be beneficial for pregnant women.

You can find chia seeds in a variety of packages, from resealable bags to jars. These jars are usually wider than resealable bags, which may be useful for folks with smaller kitchens.

These jars also come with a scooper that can be used for portion measuring. While the jars do take up more space than resealable bags, this extra room is probably worth it for most people who use chia regularly.

Another reason to consider this option is the fact that they are USDA Organic and non-GMO certified. This is a major plus for those looking to avoid synthetic pesticides and fertilizers in their diets, and it can have a big impact on flavor and texture.

These chia seeds are also very affordable and are easy to use in a variety of recipes. They have a neutral taste and smell, so you can add them to anything from smoothies to oatmeals. They are also keto-friendly, so you can eat them without compromising on your nutrition or weight goals.

Neuherbs Organic Chia Seeds are organic

Neuherbs Organic Chia Seeds are certified organic and contain all the essential nutrients. They are also a great source of fiber and protein. They are easy to incorporate into your diet, and can help you lose weight.

The chia seeds have high levels of Omega-3 fatty acids, and are known to lower your risk of heart disease. They are also rich in fibre and protein, which helps your body feel fuller for longer periods of time.

They are rich in antioxidants and anti-inflammatory properties, and can be consumed in a variety of foods. You can sprinkle them on salads, or add them to soups, smoothies, and other dishes.

A great source of Omega-3 fatty acids, chia seeds are also rich in vitamins and minerals. They help in boosting your immune system, strengthening bones and muscles, and maintaining good health.

This product is made from 100% organic ingredients and is certified by the USDA. It is hygienic and packaged in a double wrap to keep it fresh. It has a shelf life of 12 months, so you can use it for an extended period.

It contains a lot of proteins and is rich in Omega-3 fatty acids, calcium, and dietary fiber. It can also prevent diabetes and heart disease.

Unlike other seeds, chia seeds are low in calories and fat, and they help you control your appetite. They also provide you with a healthy dose of iron, magnesium, and calcium.

These chia seeds are packed with antioxidants that help fight free radicals and prevent inflammation. They can also help in soothing skin.

These chia seeds are a great source of protein, dietary fiber, and Omega-3 fatty acids. They also provide you with an energy boost and can help you lose weight.

[corrianderleaf]

Benefits of Mustard oil in Indian food

Mustard oil contains around 12% saturated fat, about 21% polyunsaturated fats, about 60% monounsaturated fatty acids (MUFA), including 42% erucic acid and 12% oleic acid, and about 6% omega-3 alpha-linolenic acid (ALA) and 15% omega-6 linoleic acid (LA).

Due to its ideal omega-3 to omega-6 fatty acid ratio and low concentration of saturated fats, mustard oil is healthier and more favored than many other oils on the market.

However reddish-brown or amber in color, mustard oil is distinguished by its potent aroma and bitter, pungent flavor. The presence of allyl isothiocyanate is what gives mustard oil its pungent flavor. You obtain this fatty vegetable oil by pressing mustard seeds.

Hence let’s take a closer look at mustard oil in Indian food and its advantages for the time being with Corriander leaf; the finest restaurant in the town.

Health Benefits of Mustard Oil

1. Cardioprotective Effects

Mustard oil is a nutritious edible oil because it has a favorable LA: ALA ratio, is high in MUFA and PUFA, notably alpha-linolenic acid, and is low in saturated fatty acids (SFA) (6:5). When mustard oil was used by Myocardial Infarct (MI) patients, arrhythmias, heart failure, and angina were decreased. As a result, mustard oil is a beneficial option for people with cardiovascular diseases.

2. Reduces Cough, Colds

Mustard oil has been used for centuries to treat allergies, asthma, coughing, and other respiratory conditions. Mustard oil steam inhalation leads to relieve respiratory congestion. Additionally, massaging our feet and chest with a mixture formed by heating mustard oil, a few garlic cloves, and a teaspoon of ajwain offers relief from a cold and a cough. Patients with sinusitis may also get benefits from mustard oil.

3. Anti-bacterial, Anti-fungal & Anti-carcinogenic Properties

The antibacterial, fungicidal, and cancer-preventive properties of glucosinolate, which is present in mustard oil, are beneficial for human health. Thus, it shields us from gastrointestinal and colorectal malignancies. Food is safe from fungus development and infection by the antifungal substance allyl isothiocyanate.

4. Strengthens Red Blood Cells

All the fats needed by our body to carry out various biological processes as parts of plasma, cell lipids, and cell membranes come primarily from mustard oil. Red blood cell membrane structure is improved and cholesterol is reduced with mustard oil (RBC).

5. Acts as a Stimulant

Our sweat glands are known to be stimulated by mustard oil, a natural stimulant, which enhances blood circulation throughout the body. Additionally, it aids in lowering body temperature and toxin removal. Increased blood circulation throughout the body helps to relax and revitalize tense, overworked muscles.

To read more click here

Website: https://corrianderleaf.com

Email: corrianderleafsocial@gmail.com

[juniperpublishersna]

In Silico Molecular Docking Study on Selective Cyclooxygenase-2 Inhibitor Drugs For SARS-Cov-2 Active Main Protease

Abstract

The coronavirus (COVID-19) pandemic became one of the most important disease problem across the globe for last few years since there is no recommended efficacious drugs in the market. So, there is an urgent need for efficient drugs to treat this disease in the near future. In the present study, molecular docking analyses of selective cyclooxygenase-2 inhibitor drugs (Celecoxib, Rofecoxib, Valdecoxib, Lumiracoxib, Parecoxib, Etoricoxib, and Firocoxib) were performed against the therapeutic target proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) enzyme into the catalytic active site. On the other hand, these drugs were compared with standard drugs such as Favipiravir, Chloroquine and Hydroxychloroquine to understand the binding sites and find the best poses. The results revealed that all the selective cyclooxygenase-2 inhibitor drugs (except Lumiracoxib) showed a better binding affinity against SARS-CoV-2 Mpro enzyme than the standard drugs. Among them, Etoricoxib (-9.40 kcal/mol) have shown the best binding affinity. As a result, this study shows that these selective cyclooxygenase-2 inhibitor drugs might be interesting lead compounds to discover more potent SARS-CoV-2 Mpro inhibitors and find to cure severe COVID-19 disease with better drugs.

Keywords: Molecular docking; Coronavirus; COVID-19; Cyclooxygenase-2 inhibitor; In silico

Introduction

An outbreak was reported by the World Health Organization (WHO) in Wuhan, China in December 2019. This epidemic was named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on January 30, 2020 [1,2]. In the second week of March 2020, the epidemic was declared global pandemic and within a few months the number of cases increased to 4 million and the death rate increased significantly [3]. The viral agent causing the outbreak belongs to the betacoronavirus family [1,2]. The disease caused by the SARS-CoV-2 factor is highly contagious [4]. This illness is basically a type of viral infection that spreads rapidly through respiratory droplet and direct contact. This infection has many symptoms, such as fever, cough, shortness of breath and gastrointestinal diseases [3,5-7]. The COVID-19 epidemic, in addition to threatening human health, has also had negative effects in areas such as the global economy around the world [3].

Cyclooxygenases are enzymes that allow free fatty acids to convert into cyclic endoperoxides. Arachidonic acid and some other fatty acids are exposed to the action of this enzyme and forming various prostaglandins [8,9]. Studies have shown that there are two different isoforms of the enzyme [8]. The first isoform, known as COX-1, is the structural form and is continuously present in the region in which it is produced. The COX-2 isoform is the inducible form [10,11]. This enzyme isoform is induced, especially in cases that cause inflammation. As a result of increased expression of the enzyme COX-2, abundant prostanoids are formed. In the presence of systemic infection, this rate increases even more. It has been found that this isoform increases in various pathologies, such as certain types of cancer and diseases of the central nervous system [8].

Microorganisms stimulate processes associated with the immune system and inflammatory events in the tissues they attack. Elimination the inflammatory condition that occurs is very important for the treatment of diseases caused by infection. In this context, polyunsaturated fatty acids (PUFA) and their metabolites play a very important role. In studies, lipid derivatives have been found to kill various microorganisms [12]. In general, PUFA kill microbes by their direct effect on microbial cell membranes. Arachidonic, eicosapentaenoic and docosahexaenoic acids act as endogenous antibacterial and antifungals. These lipid molecules also have antiviral, antiparazit and immunomodulatory effects. Cytokines involved in cell defense induce the release of PUFA from the cell membrane. These lipid molecules provide the formation of lipoxins and resolvins that have antimicrobial effects [13]. A study has shown that COX inhibition protects the virus from spreading from cell to cell by a mechanism that inhibits cytomegalovirus maturation [14]. COX-2 inhibitors such as etoricoxib or celecoxib are drugs that contribute to a decrease in mortality in severe influenza. COX-2 inhibitors are thought to be secure in the treatment of COVID-19 and may reduce disease progression in groups of high risky elderly patients with pneumonia due to their treatment of inflammation [15].

It has also been shown in previous studies that the severity and course of the inflammatory process differ decidedly between male and female [16]. Simona Pace et al. found that isolated lipopolysaccharide causes more PGE2 production in males and this may be due to increased COX-2 expression [17]. It is also thought that PGE2 levels, which are an important lipid agent and enhance more in men, may be a factor that explains the more severe disease formation condition of COVID-19 in men [16]. The parallelism of the increase in PGE2 and disease rates suggests that COX-2 inhibitors may be effective in treatment.

The aim of this study is to evaluate the place of COX-2 enzyme inhibition in COVID-19 treatment as in silico. In addition to the effect of these drugs (Scheme 1) on suppressing inflammation and reducing the severity of the disease, the ability to bind to the SARSCoV- 2 factor will be evaluated. This attachment is very important in terms of preventing the viral factor from entering the cell and preventing the effects of the disease on the body.

Material and Methods

The AutoDock 4.2 molecular docking program was used to find best binding interactions of selected selective cyclooxygenase-2 inhibitor drugs against SARS-CoV-2. The three-dimensional (3D) crystal structure of the protein Mpro was retrieved from Protein Data Bank (PDB) (PDB ID: 6LU7) [18]. The 3D structure of the drugs was downloaded from the PubChem (https://pubchem. ncbi.nlm.nih.gov/) in structure-data file format. The most suitable of the possible binding modes obtained as a result of the Molecular Docking processes were determined with Autodock 4.2, and their analyzes and visuals were obtained with the Biovia Discovery Studio Visualizer 2020 program [19-21]. In the present study, a selective cyclooxygenase-2 (COX-2) inhibitor drugs Celecoxib, Rofecoxib, Valdecoxib, Lumiracoxib, Parecoxib, Etoricoxib, and Firocoxib molecules were used for docking procedures. Also, Favipiravir, Chloroquine and Hydroxychloroquine were used as standard drugs for comparison.

Results and Discussion

The docking analysis result of the molecules and standards Celecoxib, Rofecoxib, Valdecoxib, Lumiracoxib, Parecoxib, Etoricoxib, Firocoxib, Favipiravir, Chloroquine and Hydroxychloroquine as inhibitors of SARS-CoV-2 (PDB: 6LU7) including binding energy, inhibition constant and important interactions at the active site are demonstrated in Table 1.

The protein-ligand interaction study revealed that the selective cyclooxygenase-2 inhibitor drugs are binding at the active site of SARS-CoV-2 Mpro protein with the best poses ranging from -6.27 to -9.40 kcal/mol (Table 1). In the current work, all the selective cyclooxygenase-2 inhibitor drugs showed better binding affinity then the standard drugs Favipiravir, Chloroquine, and Hydroxychloroquine (binding affinities of -4.21, -7.22, and -6.26 kcal/mol, respectively), except the Lumiracoxib. Among the best docking scores, only one drug (Lumiracoxib) has been shown the bind in a different region, then the rest of drugs (including standard drugs) and the binding energy of this drug was lowest (-6.27 kcal/ mol) among other drugs that were docked in this study (Figure 1). The best binding affinity (-9.40 kcal/mol) was observed with the drug of Etoricoxib, which have several important amino acid interactions, including hydrogen bonds with Thr 190 and Gln 192, and pi-alkyl interaction with Met 49, Pro 52, Cys, 145, Met 165, and Arg 188. The great binding affinities were also obtained with the drugs of Celecoxib, Rofecoxib, Valdecoxib, and Parecoxib, which had close binding energies to each other’s (-8.24, -8.51, -8.83, and -8.89 kcal/mol, respectively). The most important interactions with these compounds were with Cys 145 (hydrogen bonding), His 41 (pi-carbon bonding), Met 49 and Met 165 (Pialkyl interactions) (Figure 2). The moderate binding affinity was observed with the drug of Firocoxib (-7.88 kcal/mol). This drug also has some hydrogen bounds (His 41, Cys 145, Thr 190 and Gln 192), Pi-alkyl interactions (Met 49, Cys 145, His 163, and Met 165) and Pi-sigma interaction with Gln 189 (Figure 2).

In general, all the docked selective cyclooxygenase-2 inhibitor drugs showed great binding affinities against SARS-CoV-2 Mpro enzyme by having important interactions on the active site. As shown in Figure 1, only one drug (Lumiracoxib) found to bind different binding site which is not favorable for high binding affinities. Some key amino acids are important on the active site for great binding affinities such as Gly 143, Cys 145, Thr 190, and Gln 192 for hydrogen bonding, His 41 (for Pi-carbon interactions), and Met 49 and Met 165 (for Pi-alkyl interactions).

Conclusion

In summary, we have performed molecular docking of the selective cyclooxygenase-2 inhibitor drugs (Celecoxib, Rofecoxib, Valdecoxib, Lumiracoxib, Parecoxib, Etoricoxib, and Firocoxib) with the important therapeutic target protein of SARS-CoV-2 and compared them with the standard drugs Favipiravir, Chloroquine and Hydroxychloroquine. The obtained dock scores demonstrated that all the selective cyclooxygenase-2 inhibitor drugs (except Lumiracoxib) showed a better binding affinity against SARSCoV- 2 Mpro enzyme than the standard drugs. More specifically, Etoricoxib (-9.40 kcal/mol) have shown the best binding affinity. This docking study indicates that these selective cyclooxygenase-2 inhibitor drugs might be useful lead molecules to discover potent and less toxic SARS-CoV-2 drugs in the near future.

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[sanjay-chem]

Polyunsaturated Fatty Acids Market Size, Share, Demand, Growth & Trends by 2032

The global polyunsaturated fatty acids market is predicted to create an absolute dollar opportunity by exhibiting a CAGR of 5.4% from 2022 to 2032. The market size reached a valuation of US$ 5459.4 Mn in 2021 and it is to touch a valuation of US$ 5743.3 Mn in 2022. Due to polyunsaturated fatty acid’s widespread application in several industries including pharmaceuticals and healthcare, food & beverages, dietary supplements, infant formula, and several other applications, which is projection a valuation of the market of about US$ 9717.8 Mn by 2032.

As compared to the historical forecast which registered a growth of 6.7% CAGR between 2016 and 2021, the current forecast of the global polyunsaturated fatty acids market size is predicted to show sluggish growth at 5.4% CAGR between 2022 and 2032.

Various multinational companies and key players in the polyunsaturated fatty acids market have established and integrated value chains involved in manufacturing raw materials and supplying omega acids as finished products. These companies are able to integrate across several levels of the value chain whilst maintaining a meticulous supply of raw materials and keeping manufacturing costs at a minimum.

Get Your 30% Discount Now! Request for Sample @ https://www.futuremarketinsights.com/reports/sample/rep-gb-2326

Key Takeaways

Polyunsaturated     fatty acids are vital fatty acids that are essential for brain function     and cell growth. These fatty acids are not produced by the human body,     they are taken through diets. Owing to its undeniable need for the growth     of the body, the demand for polyunsaturated fatty acids is propelling in     the global market.

Polyunsaturated     fatty acids consist of omega-3 fatty acids and omega-6 fatty acids. They     are drastically being replaced by trans and saturated fats by offering     various health benefits for the body. PUFAs reduce triglycerides, prevent     arrhythmia, lower blood pressure, control blood sugar, and reduce the risk     for diabetes.

Furthermore,     PUFAs assist in brain development and enhances the body’s ability to     absorb fat-soluble vitamins more effectively along with developing and     maintaining the body’s cells. Backed by such factors, a sharp rise in the     demand for products containing polyunsaturated fatty acids has been     witnessed within the last few years and the trend is likely to drive     growth in the market.

The     surging prevalence of chronic diseases such as cardiovascular diseases,     cancer, stroke, and diabetes is expected to show opulent growth in the     sales of the polyunsaturated fatty acids market. Moreover, increased     consumption of polyunsaturated fatty acids in various end-use industries     is expected to push sales across the estimation period.

Factors     such as rising awareness about the numerous health benefits of PUFAs and a     surge in cardiovascular diseases, along with rising consumption of     products with omega-3 fatty acids are driving growth in the global     polyunsaturated fatty acids market.

Polyunsaturated     fatty acids play a vital role in improving the overall metabolic process     which results in enhancing cognitive functions. Consumers are rapidly     getting inclined toward high nutritional products is playing a crucial     role in boosting sales of polyunsaturated fatty acids.

Competitive Landscape

In order to fulfill the increasing demand for polyunsaturated fatty acids, key manufacturers in the industry are shifting their focus towards improving their production capabilities, R&D investments, collaborative partnerships, and mergers and acquisitions.

The Major Keyplayers are Koninklijke DSM N.V., BASF SE, Croda International PLC, Enzymotec Ltd., Omega Protein Corporation, Aker BioMarine AS

More Insights into the Polyunsaturated Fatty Acids Market

According to Future Market Insights, the U.S. is expected to dominate the North American polyunsaturated fatty acids market by possessing a significant share in terms of consumption. This phenomenal growth in the U.S. is driven by increasing usage of polyunsaturated fatty acids across rapidly expanding industries such as food and beverage, pharmaceutical, and nutraceutical along with the rising prevalence of cardiovascular disorders, and growing consumer awareness about the benefits of PUFAs.

Germany is projected to garner a total revenue share of about 5.9% in the global polyunsaturated fatty acids market by the end of 2022. Growth in the market is driven by the rapid consumption of foods containing polyunsaturated fatty acids.

Polyunsaturated Fatty Acids Market Key segments

By Product Type:

 Alpha-Linolenic Acid      (ALA)

 Docosahexaenoic Acid      (DHA)

 Eicosapentaenoic Acid      (EPA)

 Linolenic Acid      (LA)

 Arachidonic Acid      (AA)

By Source:

 Algal      and Fungus Oil

 Fish      Oil

 Krill      Oil

By Application:

Dietary     Supplement

Infant     Formula

Pharmaceuticals

Food     and Beverages

Animal     Food and Feed

By Form:

Oil

Syrup

Softgel     and Capsule

Other     (Powder, Emulsion and Gummy Candy)

By Region:

North     America

Latin     America

East     Asia

Europe

South     Asia & Pacific

Middle     East & Africa

Browse Full Report: https://www.futuremarketinsights.com/reports/polyunsaturated-fatty-acids-market

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Packaged Vegan Foods Market - Forecast (2022 - 2027)

EPA  & DHA Omega-3 PUFA Market size is estimated to reach $5.28 billion by 2027, growing at a CAGR of 7.81% during the forecast period 2022-2027. Omega-3 fatty acids also termed Omega-3 oils, ?-3 fatty acids, or n-3 fatty acids, are polyunsaturated fatty acids (PUFAs) featured by the existence of a double bond, three atoms away from the terminal methyl group in their chemical structure. They are extensively distributed in nature, being significant components of animal lipid metabolism, and they play a vital role in the human diet and in human physiology. The three kinds of omega-3 fatty acids included in human physiology are ?-linolenic acid (ALA), discovered in plant oils, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), both typically discovered in oils of marine fish. Currently, the oilseed crop has been genetically engineered to generate the long-chain omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) at levels identical to that discovered in fish oil, to offer a more sustainable source of these compounds than is prevailing from wild fish capture. Investigations including omega-3 fatty acid supplementation and pregnancy have indicated everyday intake of eicosapentaenoic acid and docosahexaenoic acid with either fish oil with DHA (0.5 g) and EPA (0.15 g) or with methyltetrahydrofolic acid (400 ?g), both, or placebo, from gestation week 22.

The surging inclusion of eicosapentaenoic acid and docosahexaenoic acid in the everyday diet of consumers is set to drive the EPA & DHA Omega-3 PUFA Market. The soaring applications of eicosapentaenoic acid and docosahexaenoic acid in food, dietary supplements, and clinical nutrition are set to propel the growth of the EPA & DHA Omega-3 PUFA Market during the forecast period 2022-2027. This represents the EPA & DHA Omega-3 PUFA Industry Outlook.

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Report Coverage

The report: “EPA & DHA Omega-3 PUFA Market Forecast (2022-2027)”, by Industry ARC, covers an in-depth analysis of the following segments of the EPA & DHA Omega-3 PUFA Market.

By Type: Docosahexaenoic acid (DHA), Eicosapentanoic acid (EPA), Alpha-Linolenic Acid (ALA), Others. By Source: Marine, Plant. By Application: Food And Beverages (Functional Foods & Beverages, Infant Formula), Dietary Supplements, Pharmaceuticals, Animal Nutrition, Others. By Geography: North America (U.S, Canada, and Mexico), Europe (Germany, France, UK, Italy, Spain, Russia and Rest of Europe), Asia-Pacific (China, Japan, South Korea, India, Australia & New Zealand, and Rest of Asia-Pacific), South America (Brazil, Argentina, Chile, Colombia, Rest of South America), and Rest Of The World (Middle East, Africa).

Key Takeaways

Geographically, North America EPA & DHA Omega-3 PUFA Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027 owing to the surging awareness regarding eicosapentaenoic acid and docosahexaenoic acid and the subsequent strong demand from health-conscious consumers in the North American region.

EPA & DHA Omega-3 PUFA Market growth are being driven by the soaring demand for polyunsaturated fatty acids including eicosapentaenoic acid and docosahexaenoic acid in functional foods and surging concerns for healthcare. However, the heightening cost of fish oil is one of the major factors hampering the growth of the EPA & DHA Omega-3 PUFA Market. 

EPA & DHA Omega-3 PUFA Market Detailed Analysis on the Strength, Weakness, and Opportunities of the prominent players operating in the market will be provided in the EPA & DHA Omega-3 PUFA Market report. 

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EPA & DHA Omega-3 PUFA Market Segment Analysis – By Type

The EPA & DHA Omega-3 PUFA Market based on type can be further segmented into Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Alpha-Linolenic Acid (ALA), and Others. The Eicosapentaenoic acid (EPA) Segment held the largest market share in 2021. This growth is owing to the heightening awareness regarding the health advantages of Eicosapentaenoic acid. The prenatal everyday supplementation of EPA has been discovered to provide an improved safeguard against allergic results in infants and children up to school-going age. The proliferating application of Eicosapentaenoic acid n animal feed and clinical nutrition is further propelling the growth of the Eicosapentaenoic acid (EPA) segment.

Furthermore, the Docosahexaenoic acid (DHA) segment is estimated to grow with the fastest CAGR of 8.4% during the forecast period 2022-2027 owing to the vital role of Docosahexaenoic acid for brain development at the time of pregnancy and early childhood and also its protective action against ailments like arthritis.

EPA & DHA Omega-3 PUFA Market Segment Analysis – By Application

The EPA & DHA Omega-3 PUFA Market based on the application can be further segmented into Food And Beverages, Dietary Supplements, Pharmaceuticals, Animal Nutrition, and others. The Dietary Supplements Segment held the largest market share in 2021. This growth is owing to the soaring accessibility of dietary supplements including Eicosapentaenoic acid and Docosahexaenoic acid worldwide. Eicosapentaenoic acid is utilized in integration with docosahexaenoic acid (DHA) in fish oil preparations for an assortment of conditions, inclusive of averting and reversing heart disease. The surging awareness of the health benefits of Eicosapentaenoic acid and Docosahexaenoic acid is further propelling the growth of this segment.

Furthermore, the Food And Beverages segment is estimated to grow with the fastest CAGR of 8.6% during the forecast period 2022-2027 owing to the surging application of Docosahexaenoic acid in infant formula in conjunction with the proliferating birth rates and purchasing power of parents worldwide.

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EPA & DHA Omega-3 PUFA Market Drivers

Soaring Benefits Of Eicosapentaenoic Acid (EPA) Are Projected To Drive The Growth Of EPA & DHA Omega-3 PUFA Market:

Eicosapentaenoic acid (EHA) brings about certain very powerful health benefits. Investigations indicate that the eicosapentaenoic acid in fish oil supplements can assist in the reduction of numerous hazard determinants pertaining to cardiovascular disease, inclusive of arterial calcification, high blood pressure, and raised triglycerides. Introductory research recommends that EPA assists in averting the build-up of calcium residues in arteries. It minimizes the symptoms of depression. It alleviates the symptoms of menopause. It minimizes symptoms and delays the advancement of rheumatoid arthritis. The soaring benefits of Eicosapentaenoic Acid (EPA) are therefore fuelling the growth of the EPA & DHA Omega-3 PUFA Market during the forecast period 2022-2027.

EPA & DHA Omega-3 PUFA Market Landscape:

Product launches, mergers and acquisitions, joint ventures, and geographical expansions are key strategies adopted by players in the EPA & DHA Omega-3 PUFA Market. Key companies of this market are:

Zymes LLC

Barleans Organic Oils

Denomega Nutritional Oils

Copeinca ASA

Martek Biosciences Corporation

Omega Protein Corp

Horizon Organic

Golden Omega

Pharma Marine USA LLC

Pesquera Pacific Star S.A.

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Recent Developments

In December 2021, Horizon Organic who declared this summer that it would halt the purchase of milk from 89 organic dairy farms in the Northeast next August has proffered to expand those contracts for another six months. Danone, the parent firm of Horizon Organic, alerted officials in Vermont, Maine, and New York this week. The 28 farms in Vermont and a total of 61 in Maine, New Hampshire, and New York were anticipated to lose their contracts at the end of August next year when Danone would halt the purchase of milk in the region.

In October 2021, GC Rieber VivoMega declared the introduction of the VivoMega soft-gel sampling program. Accessible to North American customers, the firm pronounces that the samples will demonstrate how its omega-3 constituents can be utilized to aim distinct health advantages. The constituent is targeted to permit better taste and smell, and with omega-3 oils, there is a minimum sensory experience, inclusive of minimization in fishy aftertaste or belches.

In March 2021, Horizon Organic® Growing Years™ teamed with pediatricians to extend the product line. With novel partners in tow, the natural dairy brand doubles down on development in this key sector. Horizon Organic® declared the extension of its Growing Years™ line to presently involve low-fat yogurt pouches, cultured dairy smoothies, reduced-fat milk half gallons, and single-serve whole milk boxes accessible currently at grocery stores countrywide.

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Asia-Pacific Polyunsaturated Fatty Acids | BIS Research Market Analysis - 2021-2026

The consumers across the globe are progressively taking proactive measures to optimize their immune health, and seeking accessible, affordable, and reliable nutritional solutions to fulfil their demand. Incorporating PUFAs in daily life mainly in dietary supplements, food and beverages can likely to help people to overcome such chronic diseases and tackle Covid-19 outbreak.

APAC PUFAs market is at the growing stage. Download the Sample Doc at: https://bit.ly/3vByQFm

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Global Polyunsaturated Fatty Acids (PUFAs) Market 2021 In Deep Analysis, Expert Reviews and Precise Outlook 2028

Along with the market overview, which includes market dynamics, the chapter includes a Porter's Five Forces analysis, which explains the five forces in the Global Polyunsaturated Fatty Acids (PUFAs) Market: buyers bargaining power, suppliers bargaining power, threat of new entrants, threat of substitutes, and degree of competition. 

It describes the various market participants, such as system integrators, intermediaries, and end users, within the market ecosystem. The report also examines the Global Polyunsaturated Fatty Acids (PUFAs) Market competitive landscape.

Growth in fisheries production is expected to provide opportunities for the polyunsaturated fatty acid market. Growing demand for krill oil and highly concentrated fish oil is also expected to drive Polyunsaturated Fatty Acids (PUFAs) Market growth. The widespread availability of chia seeds, which are high in -linolenic acid, is also expected to boost consumption.

Read more @ https://creativeedge16.blogspot.com/2022/03/global-polyunsaturated-fatty-acids.html

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POLYUNSATURATED FATTY ACIDS (PUFAS) MARKET ANALYSIS(2020-2027)

Polyunsaturated Fatty Acids (PUFAs) Market, By Product Type (Omega-3 Fatty Acids (Alpha-Linolenic Acid (ALA), Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid (EPA)), Omega-6 Fatty Acids (Linolenic Acid (LA), Arachidonic Acid (AA))), By Source (Marine (Algal and Fungus Oil, Fish Oil, Krill Oil), Plant (Chia Seed Oil, Flax Seed Oil, Other)), By Form (Oil, Syrup, Softgel and Capsule, Other), By Application (Dietary Supplement, Infant Formula, Pharmaceuticals, Food and Beverages, Animal Food and Feed), and By Region (North America, Latin America, Europe, Asia Pacific, Middle East & Africa) - Size, Share, Outlook, and Opportunity Analysis, 2020 - 2027

Polyunsaturated fatty acids are compounds that have more than one unsaturated carbon bond. They are important fats which cannot be produced by the human body hence it is required to consume through food as it improves the overall metabolic process. They have beneficial effects on the cardiovascular system and also helps to enhance the cognitive functions.

The global polyunsaturated fatty acids (PUFAs) market is projected to reach around US$ 12,849.3 million by the end of 2027, in terms of revenue, growing at CAGR of 10.3%during the forecast period (2020-2027).

Drivers:

Growing prevalence of cardiovascular disease along with the rising awareness regarding the PUFAs for treating chronic disease is primarily fueling the market growth. According to the U.S. Department of Health & Human Services, about 647,000 Americans die from heart disease each year that’s 1 in every 4 deaths. Therefore, the growing prevalence of the cardiovascular disease is projected to foster the market growth of polyunsaturated fatty acids.

Figure 1. Global Polyunsaturated Fatty Acids (PUFAs) Market Share (%) in terms of Value, By Region, in 2019

Europe region dominated the global Polyunsaturated Fatty Acids (PUFAs) market in 2019, accounting for 39.3% share in terms of value, followed by North America and Asia Pacific, respectively.

Market Restraints:

Lack of awareness regarding the health benefits associated with consumption of PUFAs owing to a few marketing and promotional activities in rural areas is expected to hinder the market growth of polyunsaturated fatty acids.

Market Opportunities:

Increasing consumption of marine-derived polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) for treating various types of cancer is expected to serve major growth opportunities. It acts as an effective adjuvant to chemotherapy treatment and have anticancer effects that help in treating the cancers. Thus, growing consumption of marine-derived polyunsaturated fatty acids for preventing cancers is expected to fuel the market growth.

Growth in fisheries production is projected to provide potential opportunities to the market of polyunsaturated fatty acids. Growing demand for krill oil and highly concentrated fish oil is also expected to accelerate the market growth of polyunsaturated fatty acids. High availability of chia seeds that are a rich source of α-linolenic acid is further expected to increase the consumption of PUFAs in Brazil country. All these factors are projected to foster the market growth.

Figure 2. Global Polyunsaturated Fatty Acids (PUFAs) Market– Opportunity Analysis

Market Trends:

Manufacturer are introducing products such as soft gels, oils, and capsules that contain docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is a major trend in the market. For instance, in February 2020, Wiley Companies a producer of AlaskOmega® omega-3 fish oil concentrates and natural fish oils announced that it has launched an MSC-certified omega-3 concentrate powder for use in food, beverage, and dietary supplement formulations.

Increasing consumption of super-fortified food across developed countries is a major trend in the market. This trend is expected to foster the market growth of polyunsaturated fatty acids. The growing health wellness trend is leading to the rapid adoption of a healthy lifestyle among consumers which is also projected to augment the market growth. Moreover, a growing number of consumers participating in various sports and other physical activities is further expected to stimulate the market growth of polyunsaturated fatty acids over the foreseeable time period.

Figure 3. Global Polyunsaturated Fatty Acids (PUFAs) Market Share (%) in terms of Value, By Application, in 2019

On the basis of application in 2019, the dietary supplement segment has accounted the largest market share of 47.4% in terms of value, followed by infant formula and food & beverage segment respectively.

Global Polyunsaturated Fatty Acids (PUFAs) Market - Impact of Coronavirus (Covid-19) Pandemic:

Demand for dietary supplements has grown during the coronavirus pandemic as it helps to boost immunity. According to U.S. FDA (Food and Drug Administration) coronavirus cannot be transmitted through dietary supplements or their packaging. However, manufacturers are experiencing increased prices and potential shortages of raw materials to meet the consumer demand. Sales of supplements addressing cold, flu and immunity are expected to grow at a substantial rate during the pandemic and post pandemic period. According to Coherent Market Insights, demand for polyunsaturated fatty acids (PUFAs) during the pandemic.

Competitive Section:

Company Names

Koninklijke DSM N.V.

BASF SE

Croda International PLC

Enzymotec Ltd.

Omega Protein Corporation

Aker BioMarine AS

Polaris Nutritional Lipids

FMC Corporation

Cargill, Incorporated

10.GlaxoSmithKline plc.

Few Recent Developments:

In July 2019, Royal DSM, a global science-based company in Nutrition, Health, and Sustainable Living, today together with Evonik celebrated the grand opening of their Veramaris 50-50 joint venture's commercial-scale US$200 million production facility located in Blair, Neb. (USA).

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[nileshdbmr]

Walnuts are derived from walnut tree. Walnuts comprise excellent fats, including monounsaturated and polyunsaturated fats (PUFAs), but are also a precious vegetarian source of vital omega-3 fatty acid. In addition, they contain iron, selenium, calcium, zinc, vitamin E and some vitamins B.