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[medicomunicare]

Resisting arrest: ribosomials, oncogenes, tumor suppressors and enzymes coordinate to induce cell suicide in leukemia

Acute lymphoblastic leukemia (ALL) is a highly aggressive cancer. Numerous genetic subtypes of ALL have been identified, including Philadelphia chromosome-positive B-cell ALL (Ph+B ALL) which comprises approximately 25-30% of all adult ALL. Ph+B ALL is characterized by the t(9;22) chromosomal translocation that generates the BCR-ABL1 fusion gene resulting in abnormal tyrosine kinase signaling in…