#Pharmaceutical Research

[chemxpert]

India’s Top API Manufacturing Companies & Their Services

Currently, India is the world's leading producer of pharmaceutical products especially the Active Pharmaceutical Ingredients (APIs). It is these API’s that are the active ingredients of medications that bring about the desired therapeutic effects. This blog will focus on the top API pharma companies with their services and their role in the industry.

[emerging-tech]

Quantum Computing: How Close Are We to a Technological Revolution?

1. Introduction Brief overview of quantum computing. Importance of quantum computing in the future of technology. 2. Understanding Quantum Computing Explanation of qubits, superposition, and entanglement. How quantum computing differs from classical computing. 3. The Current State of Quantum Computing Advances by major players (Google, IBM, Microsoft). Examples of quantum computing…

[bostonresearchjournals]

Pharmaceutical Journals: Essential Reads for Pharmacologists Access top pharmaceutical journals that provide valuable insights and the latest developments in pharmacology. Perfect for keeping abreast of industry advancements.

[aerilynhealthcare]

Corporate Hospitals: Bridging Community Needs and Business Strategies

As modern healthcare evolves, the role of corporate hospitals continues to shape the landscape of medical service provision. This article explores the intersection between corporate strategies and community wellbeing through the lens of corporate hospitals, drawing insights from recent studies and industry trends.

Defining Corporate Hospitals

Corporate hospitals refer to healthcare institutions owned by for-profit entities, which seek to generate returns for investors while providing essential medical services to local populations. While historically associated with negative connotations due to concerns regarding profit margins versus patient care, contemporary corporate hospitals strive to balance their dual responsibilities—to deliver high-quality care and fulfil their obligations as community stakeholders.

Unique Challenges and Opportunities

Research indicates that for-profit hospitals encounter distinct challenges compared to their nonprofit counterparts. Stigma surrounding for-profit operations sometimes limits partnership opportunities and hinders community engagement. Additionally, the growth of corporate giants purchasing primary care practices raises questions about the impact on patient care and the distribution of wealth among providers. 

However, corporate hospitals possess several advantages. They offer innovative solutions to address community needs, leverage economies of scale to improve operational efficiencies, and attract investments that enable expansions and technological advancements. Furthermore, corporate hospitals pay taxes, contributing to local economies and infrastructure improvements.

Case Study: Aerilyn Healthcare

While not explicitly mentioned in the provided search results, Aerilyn Healthcare represents a prominent player in the corporate hospital space. By examining Aerilyn's commitment to community involvement, we can gain insight into the broader context of corporate hospitals' role in society.

At Aerilyn Healthcare, the company actively engages in initiatives aimed at improving population health and reducing disparities. Through collaborations with local governments, schools, and community groups, Aerilyn fosters a culture of shared responsibility and mutual benefit. Their dedication to community wellness extends beyond the walls of their hospitals, reflecting a holistic understanding of the interconnectedness between healthcare and societal factors.

Looking Ahead

As corporate hospitals continue to grow and adapt to meet the evolving needs of their communities, it becomes increasingly crucial to ensure that their actions remain aligned with the best leading pharma interests of patients and the greater good. To achieve this, corporate hospitals must maintain open communication channels with local stakeholders, demonstrate transparency in decision-making processes, and continually evaluate the effectiveness of their community engagement strategies.

By embracing their role as responsible corporate citizens, corporate hospitals can help drive positive change in the lives of millions worldwide, ultimately strengthening the fabric of our global healthcare ecosystem.

[thewitfire]

Revolutionizing New Drug Delivery System: Pharmaceutical Research

Revolutionizing New Drug Delivery System: Pharmaceutical Research. #pharmaceuticalresearch #PharmaceuticalResearch

New Drug Delivery System- Pharmaceutical researchers are striving to create more efficient drug delivery systems. The goal is to enhance medication absorption, increasing their potency while decreasing side effects. Drugs have historically been administered via oral, topical, intravenous, and inhalation. While these methods can be effective in many cases, they also have drawbacks such as poor…

[happy-smile-flowers]

Targeting chemical synthesis through a single ibuprofen

Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug!

As an essential part of the development of the pharmaceutical industry, the chemical synthesis of drugs is the primary source of candidate drugs. It is also a high-input, high-output, and high-efficiency work.

The research and development directions of chemically synthesized drugs mainly include the following:

Research and development of new chemical entity drugs;

Create "Me-too" new drugs—research and development of imitative new drugs;

Further research and development of known drugs;

Pharmaceutical research and development of existing drugs;

Research on new uses of existing drugs;

Avoiding patented technology.

Medicilon is proud of our extensive expertise in synthetic organic chemistry, providing chemical synthesis services. Medicilon's synthetic chemistry team can independently design synthesis pathways and complex compound treatments, which is key to helping accelerate our clients' drug discovery.

Recently, Ibuprofen has been hard to find and has become a hard currency.

1.Ibuprofen

Ibuprofen, molecular formula C13H18O2, chemical name 2-(4-Isobutylphenyl)propanoic acid. Ibuprofen is a commonly used non-steroidal anti-inflammatory drug (NSAID), which produces analgesic and anti-inflammatory effects by inhibiting cyclooxygenase and reducing prostaglandin synthesis; it acts as an antipyretic agent through the hypothalamic thermoregulatory center. Ibuprofen is usually well tolerated and does not usually cause clinically significant severe acute liver injury.

2. Ibuprofen indications

Oral administration: For the relief of mild to moderate pain such as arthralgia, neuralgia, muscle pain, migraine, headache, dysmenorrhea, and toothache, and also for the relief of fever due to the common cold or influenza. Injectable administration: for antipyretic and analgesic treatment: for mild to moderate pain, as an adjunct to opioid analgesics for moderate to severe pain; antipyretic therapy of fever.

3. Ibuprofen mechanism of action

Ibuprofen is a diastereomeric chiral drug containing R- and S-ibuprofen. Pharmacokinetic studies have shown that most of the pharmacologically active form of the drug is contributed by its S-enantiomer, as it inhibits prostaglandin synthesis. In the early to mid-1970s, the first report of the conversion of the inactive R-enantiomer to the active S-enantiomer by unidirectional enzymatic conversion was made. Approximately 40-60% of the R-enantiomer is metabolized in the liver to the S-ibuprofen form. Its anti-inflammatory effect is due to the inhibitory activity of S-ibuprofen on cyclooxygenase (COX), which is responsible for prostaglandin synthesis and plays a vital role in neuronal death mediated by an increased inflammatory response. Ibuprofen inhibits COX, reduces nitric oxide (NO) production, and activates peroxisome proliferator-activated receptor-γ (PPAR-γ).

4. Ibuprofen Chemical Synthesis

Ibuprofen was first patented by Boots Pure Chemical Company in 1961 and approved as an over-the-counter drug in 1984. Since its introduction, Ibuprofen has been marketed under several brands, including Advil® and Motrin®. The synthesis of ibuprofen begins with isobutyl benzene. The synthesis process includes Friedel-Crafts acylation, reduction, chloride substitution, and the Grignard reaction. The products of each step were then analyzed by IR and 1 H NMR spectroscopy, and the final product was confirmed by melting point determination analysis. In 1992, BHC developed a new sustainable synthesis method that cut the synthesis steps in half. The first step uses anhydrous hydrogen fluoride as the catalyst and solvent, which is then recycled and reused. In addition, the real highlight behind the BHC method was the reduction of unwanted waste and impurities, generating only one water molecule as a by-product. This led to a genuinely green synthesis.

In 2009, Andrew R. Bogdan et al. of Florida State University used a microreactor to synthesize Ibuprofen. Microreactors are safer, more efficient, and more selective chemical transformations in microchannels or narrow bore tubes. Using isobutyl benzene and propionic acid as feedstock, the total reaction time was approximately 10 minutes, with a crude yield of 68% and a yield of 51% after recrystallization (99% purity by GC and NMR analysis).

In 2014, David R. Snead, Ph.D., and Professor Timothy F. Jamison of Massachusetts Institute of Technology (MIT) performed a multi-step sequential reaction using isobutylene and propionyl chloride as feedstocks. Ibuprofen was assembled from its basic structural units in three minutes, with an average yield of over 90% at each step from the starting material to the target compound.

References

[1] Ashish Singh et al. Neuroinflammatory responses in Parkinson's disease: relevance of Ibuprofen in therapeutics. Inflammopharmacology. 2021 Feb;29(1):5-14. DOI: 10.1007/s10787-020-00764-w. [2] Mark A. Murphy. Early Industrial Roots of Green Chemistry and the BHC Ibuprofen process invention's history and quality connection. Foundations of Chemistry volume 20, pages 121-165 (2018). [3] Andrew R Bogdan, et al. The continuous-flow synthesis of Ibuprofen. Angew Chem Int Ed Engl. 2009;48(45):8547-50. doi: 10.1002/anie.200903055. [4] David R Snead et al. A three-minute synthesis and purification of Ibuprofen: pushing the limits of continuous-flow processing. Angew Chem Int Ed Engl. 2015 Jan 12;54(3):983-7. DOI:

[destielmemenews]

"The researchers have not tested the process on humans, and it’s not clear what dosage of dye or delivery method would be necessary. Human skin is about 10 times thicker than that of a mouse, according to the researchers.

“Looking forward, this technology could make veins more visible, easing … the procedure of drawing blood or administering fluids via a needle — especially for elderly patients with veins that are difficult to locate,” said senior author Guosong Hong, a Stanford assistant professor of materials science, via email.

“Moreover, this innovation could assist in the early detection of skin cancer, improve light penetration for deep tissue treatments like photodynamic and photothermal therapies, and make laser-based tattoo removal more straightforward.”"

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[pinacoladamatata]

Retail Rifts meetcute in the juice aisle.....

[jawz]

people can dislike detransitioners all they want but regardless of that, it is still important to study our experiences… trans people fully deserve to know what the effects will be if they have to or decide to stop taking their medications for any reason.

[chasingrosesandbooks]

I came across her name while skimming through my pharmaceutical chemistry notes and ended up spending the next hour reading about her: she's Tu Youyou, a pharmaceutical chemist who won the Nobel Prize for medecine in 2015 for discovering of artemisin, an effective antimalarial drug.

Interesting facts about her:

She's the first Chinese Nobel Prize winner who studied and conducted her research without ever leaving China.

Her father picked her name while he was eating a dish based on the same plant she would later study and extract artemisin from (what a coincidence!)

She traveled across China and met many experts of Chinese medical science throughout her research. She considers her discovery "a gift to the world from traditional Chinese medicine".

She volunteered to be the first human to test the effects of artemisin.

Her research began to treat soldiers during the Vietnamese war.

I've procrastinated my studies, but I'm glad I found out about this amazing women ❤️

[chemxpert]

Comprehensive Solutions for the Pharmaceutical Industry

Chemxpert Database offers a holistic approach to the pharmaceutical industry, connecting pharmacovigilance companies and pharma software companies with essential pharmacovigilance services. Leveraging data science in the pharmaceutical industry, we cater to pharmaceutical companies in Singapore and beyond, ensuring safety, compliance, and efficiency. Explore our solutions for a seamless experience in managing drug safety and regulatory requirements.

[stuckinapril]

In hs one night before I went to college literally decided to go into the medical field because I was thinking about people with Alzheimer and it made me sad

Anon why are you so me!! To be clear I’ve wanted to be a doctor my whole life, and neurosurgery has def been a dream of mine for a minute, but yeah the interest in Alzheimer’s is a direct result of scoring my neurodegenerative diseases internship. It’s all just so fuckin sad. The longitudinal study I’m helping with is literally purely observational, bc there’s absolutely nothing that can be done about dementia aside from mitigating it. Rly struggling to reconcile how interesting it all it to how depressing it is to watch people fade away

[bostonresearchjournals]

Exploring Pharmaceutical Journals for Cutting-Edge Pharmaceutical Research

Dive into the world of pharmaceutical research with our curated list of essential pharmaceutical journals.

[brightlotusmoon]

Random person trying to make friends: Yeah, so, I don't trust those crazy drugs or vaccines, they cause too much injury and we probably don't need them. So, what are your hobbies?

Me, shoving bread sticks in my metaphorical purse: That's great. I gotta go. Nice chatting with you!

[thewitfire]

New Developments in Pharmaceutical Research Offer Hope for Devastating Diseases

New Developments in Pharmaceutical Research. #research

New Developments in Pharmaceutical Research- This article summarizes three recent news articles highlighting the latest advancements in pharmaceutical research. From a new treatment for Alzheimer’s disease to a promising vaccine for malaria and gene therapy for sickle cell disease, these developments offer hope for patients and families affected by these devastating diseases. Photo by…