#People&039;s approval

[dwuerch-blog]

Pleasing People. Pleasing God.

People’s approval has been my go-to most all my life. I want my husband’s family to like me. For goodness’s sake – I want my husband to like/love me a lot. I want my fellow workers and customers at the family center to like me. I want my blogs to be liked and loved.I WANT – ugh! But I’ve learned some valuable lessons. While we don’t want to spend our lives trying to get people to approve of us,…

[in-sightjournal]

Ask A Genius 979: The Never-Book "Dumbass Genius"

Scott Douglas Jacobsen: A question from someone else: When is your book coming out? Rick Rosner: Yeah, well, I don’t have an autobiography coming out. I semi-abandoned that. It’s still there if somebody wants to pay me to write it. But before that book comes out, I’m writing this other book that’s a more fictionalized version of what it’s like to be competent in the world with a whole different…

[word4utoday]

Free from people’s approval

Free from people’s approval

There’s a world of difference between performing for people’s approval, and being free to minister to their needs because you know you already have God’sapproval. Striving for approval is like any other drug; you can never get enough of it. And like all drug addicts you go crazy when it’s withheld. It places you at the mercy of other people’s opinions, and as a result you live on an emotional…

[stevenhaard]

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spiritual things are as real as the air that you breathe

it does not end when you die

it just begins

why can't you see that i am trying to help you

https://www.bitchute.com/video/rtJ6ids7LpFM/

[mystlnewsonline]

PYONGYANG, North Korea | North Korea goes to polls to approve new parliament lineup

PYONGYANG, North Korea | North Korea goes to polls to approve new parliament lineup

PYONGYANG, North Korea (AP) — Millions of North Korean voters, including leader Kim Jong Un, went to the polls on Sunday to elect roughly 700 members to the national legislature.

In typical North Korean style, the vote was more of an endorsement than a competitive contest — voters were presented with just one state-sanctioned candidate per seat. They cast their ballots to show their approval or,…

[bdbankingnews-blog]

আজ অনুমোদন পেতে যাচ্ছে নতুন চার ব্যাংক

আজ অনুমোদন পেতে যাচ্ছে নতুন চার ব্যাংক

ব্যাংকিং নিউজ বাংলাদেশঃ একাদশ জাতীয় সংসদ নির্বাচনের আগে অনুমোদন পেতে যাচ্ছে নতুন আরও চার ব্যাংক। অর্থমন্ত্রী আবুল মাল আব্দুল মুহিতের কয়েক দফা চিঠি চালাচালির পর অব��েষে আজ সোমবার (২৯ অক্টোবর) বাংলাদেশ ব্যাংকের পরিচালনা পর্ষদের সভায় নতুন এ চারটি ব্যাংকের কার্যক্রম পরিচালনার অনুমোদন পেতে যাচ্ছে।

যেসব ব্যাংকের অনুমোদন দেওয়া হবে সেগুলো হলো- ‘বেঙ্গল কমার্শিয়াল ব্যাংক লিমিটেড’, ‘পিপলস ইসলামী ব্যাংক…

[russianreader]

Twenty Percent of Russian Schoolteachers Think about Quitting A quick lesson in how certain professional are subjugated and co-opted by the Putin regime. Twenty Percent of Russian Schoolteachers Contemplate Quitting Salaries Lower than Official Rates, While Workload Is Extremely Heavy…

[in-sightjournal]

Ask A Genius 978: Immediate Pre-Debate Thoughts on Trump and Biden

Scott Douglas Jacobsen: I’m looking at the 538 polls from June 25 to June 17. As far as I can tell from the favorability and unfavorability ratings, Trump is about 10 or 11% unfavourable. Rick Rosner: Trump’s net unfavourable rating is about 11.5%.That doesn’t look good. So, he’s in the hole by 11.5%, which seems good for Biden, except Biden’s in the hole by more than 17%. Jacobsen: Why do…

[vivanaija]

House Of Reps consider Impeachment Proceedings against Buhari over $496Million spending

House Of Reps consider Impeachment Proceedings against Buhari over $496Million spending

Our foster father, Muhammadu Buhari got his and our money, lied to us, condemned us, like every other man in the Nigerian government we know have. But they’ll eventually get what’s coming to them. Impeachment or not, for we know even that one, could easily slide. It’s Buhari. The spending $496m without parliamentary approval has pitched Pres. Buhari against the House of Representatives with most…

[deeplyawake]

Deeply Awake Chats 2017: Raw Honey By Kathy Vik 8-2-17

Deeply Awake Chats 2017: Raw Honey By Kathy Vik 8-2-17

    A complex, beautiful, redemptive and intense talk which is at once soft and explosive, in that, new thoughts and and new identity has taken root, and as a result, much has and is spun off, and many thoughts are generated as a result of all this change. I think what is here will help to illuminate, tickle and give relief to many…

[wescrumptiouslyghostlycollection]

Importance Of Couples Dance Classes Brookings SD

Importance Of Couples Dance Classes Brookings SD

By Marie Reed At the point when your couples moving you have to keep up adjust for two reasons. You require ensure that you don’t fall or bumble and you have to ensure that you don’t put your accomplice reeling. This writing will highlight the benefits of Couples dance classes Brookings SD and ways it hence love among the marrieds. This can be a standout amongst the best time things you can do to…

[thinkaboutnetwork-blog]

10+ Emotional Same Sex Wedding Pics That Will Hit You Right In Your Soft Spot

10+ Emotional Same Sex Wedding Pics That Will Hit You Right In Your Soft Spot

June is LGBTQ Pride Month, and there’s no better way to celebrate it than sharing these touching same-sex wedding photos.

At the end of the 20th century, gay marriage ceremonies without legal recognition became more and more popular. The first nation, however, to provide law for the marriage of same-sex people was the Netherlands (2001). This marked a turning point in public approval for…

[kj1966-blog]

Donald Trump’s 100 days results show 0.01% delivered promisis Considering Donald Trump's history, his failure to deliver results is logical. Looking forward it is also logical to conclude that the likelihood of him to cause irreversible damage to the U.S. economy is very high.

[jobswzayef]

Commercial Operations Specialist

Commercial Operations Specialist Role Summary First level support to the Service Sales function. Follow and execute the W2W process from quotation to invoice preparation and handover to the Cash team. Analyzes sales market data. Coordination of all customer issues across functions like service delivery logistics amp finance. Support the commercial operations leader in SFE amp other activities related to driving growth by setting up effective processes to collect amp analyze data. Essential Responsibilities Ensure first class service contract process execution on customer service contracts noncontract services install base data entry and data quality. Ensure timely and accurate billing of customers for contract and non contract services. Be the gatekeeper to the service P amp L by ensuring quality revenue being booked by meeting all revenue recognition criteria and taking proper approvals as per the existing DOA s . Ensure quality and integrity of the customer contracts as they are entered into the system. Act as liaison partner with Service Sales Field Service and Customers to meet commitments and resolve issues related to invoicing and contract administration. Aware of and comply with the GEHC Quality Manual Quality Management System Quality Management Policy Quality Goals and applicable laws and regulations. Identify and report any quality or compliance concerns and take immediate corrective action as required Qualifications Requirements A Bachelor 039 s Degree from an accredited college or university Minimum of 1 years of experienced in Sales Marketing Operations within the Healthcare industry Excellent written and verbal communication skills exhibits the ability to interact effectively with various types of people Proficient at PC office software such as excel word PowerPoint etc. Detail oriented commitment to deliver the results Ability to operate effectively in a multi tasking dynamic environment while maintaining a forward thinking and customer first attitude. Arabic amp English language capability in both spoken and written Desired Characteristics Commercial and or finance background is preferred Good presentation and problem solving skills thorough attention to detail and the capability to meet deadlines Ability to adapt to change and willingness to be flexible at all times. Excellent written communication skills and ability to document commercial information in an easy to understand and straightforward manner. About Us GE NYSE GE drives the world forward by tackling its biggest challenges. By combining world class engineering with software and analytics GE helps the world work more efficiently reliably and safely. GE people are global diverse and dedicated operating with the highest integrity and passion to fulfill GE 039 s mission and deliver for our customers * راتب مجزي جداً. * مكافأت و حوافز متنوعة. * توفير سكن مؤثث أو بدل سكن. * أنتقالات أو توفير بدل عنها. * توفير تذاكر السفر لمن يشغل الوظيفة و عائلته. * نسبة من الأرباح الربع سنوية. * أجازات سنوية مدفوعة الراتب بالكامل. * مسار وظيفي واضح للترقيات. * بيئة عمل محفزة و مناسبة لحالة الموظف. * تأمين طبي للموظيف و عائلته. * تأمينات أجتماعية. التقدم و التواصل مباشرة دون و سطاء عند توافر الألتزام و الجدية التامة و المؤهلات المطلوبة علي: jobswzayef@gmail.com

[patchsing3-blog]

Amazon's Headquarters Bidding War Puts It in a Spotlight

SEATTLE, United States — In September 2017, Amazon.com Inc. became America’s most eligible corporate bachelor when it announced plans for a second headquarters. More than 200 cities across North America fell over themselves trying to woo the e-commerce giant and the 50,000 well-paying tech jobs on offer. The more shameless attempts to win Amazon’s attention included Arizona trucking a cactus to Seattle and a Georgia town offering to rename itself, yes, Amazon.

Exactly one year later, negotiations with 20 finalist cities from New York to Los Angeles have retreated behind closed doors. Instead of public displays of affection, Amazon is fending off barbs sharper than the prickers on that 21-foot saguaro cactus. As the world’s second-most valuable public company weighs the tax breaks and other goodies proffered by eager suitors, it stands accused of being a corporate welfare leech that should be giving the government and its workers more rather than further milking taxpayers to expand. As the world’s wealthiest individual, chief executive officer Jeff Bezos also makes a fat target.

Vermont senator Bernie Sanders has accused Amazon of forcing its warehouse workers onto food stamps because it doesn’t pay them enough; he proposed levying a tax on large employers to help fund government assistance (the bill is called Stop Bad Employers by Zeroing Out Subsidies Act — or Stop BEZOS). Meanwhile, increasing numbers of states are reviewing whether companies are honouring their pledges to create jobs and generate economic activity. As the HQ2 bake off drags on in private, Amazon gives its critics more ammunition and time to fire away.

“The Bernie Sanders bill shows how much Amazon's brand has been tarnished by this headquarters search process,” says Greg LeRoy, executive director of Good Jobs First, which monitors government investments in businesses. “The way they launched this public auction was really ham handed. It was an obvious grab for the maximum tax break, and now they’re under the microscope.”

Amazon declined to comment for this story. In a blog post responding to Sanders, the company said it created 130,000 new jobs last year and that employees receiving food stamps include those who work part-time or only worked at Amazon for brief periods. The company defended its treatment of workers, saying its full-time US warehouse employees earn more than $15 an hour on average, including stock and incentive bonuses. The company also says it has invested more than $100 billion in the US since 2011 and created more than 200,000 full-time jobs with benefits.

The Sanders bill is unlikely to go anywhere so long as the Republicans control Congress. But more and more states are taking a closer look at trading tax breaks for jobs. Politicians eager to attract employers to their cities and towns during the Great Recession later discovered that perhaps they had given away too much and received too little in return. Among the notable boondoggles: “The Buffalo Billions” corruption scandal in New York where money meant for economic development instead allegedly went to allies of Governor Andrew Cuomo; in 2010 the Rhode Island Economic Development Corp. issued $75 million in bonds as part of a package to lure video game company 38 Studios away from Massachusetts in a deal that went bust and resulted in federal fraud charges.

Such blowups prompted several states to tighten controls, including Pennsylvania, Texas, Colorado, Illinois and Georgia, collectively home to seven Amazon finalist cities. Texas, for instance, withdrew or clawed back more than $30 million in incentives to 16 companies that failed to create the jobs pledged, according to a 2017 legislative report. California, New York, New Jersey and Massachusetts — also among the finalists — are among 22 states that lack robust oversight of government investments in business, but that group is shrinking, according to a 2017 study by The Pew Charitable Trusts.

“Over the past six years, we’ve seen vast improvement,” says Josh Goodman, a researcher at Pew. “Lawmakers are saying we need good information to understand how these programs are working and how they can be improved.”

Amazon is likely to welcome greater scrutiny of the economic splash made by its second headquarters, eager to steer the narrative from corporate welfare to job creation. The company has pledged to invest $5 billion over 18 years and said compensation including benefits would average about $100,000 for the 50,000 jobs expected. The company has said it will make a decision this year and has otherwise been mum. Atlanta, the Washington, D.C. region, Philadelphia and Austin are among the places considered front-runners by Moody’s Analytics and others that analysed the finalists based on Amazon’s criteria, which included a large labor force, proximity to an airport and a good education pipeline.

Most offers from the finalist cities remain private, but the scope of the project makes it an inevitable “mega-deal” in the billions of dollars. New Jersey has offered a package worth $7 billion to lure Amazon to Newark. Maryland is dangling $6.5 billion in tax incentives to get Amazon to set up shop in Montgomery County. Such offers prompt concerns that cities and states could overspend. Amazon has the strongest support in Atlanta, Indianapolis and Pittsburgh, according to a poll conducted in April by Elon University, and the strongest opposition in Denver and Austin.

In the Seattle region, Amazon employs 45,000 people and the company says it has created an additional 53,000 jobs, pushing the city's unemployment rate below four percent and fuelling one of the hottest real estate markets in the country. Yet, even in Seattle, the company is under attack and was the primary target of a payroll tax meant to raise money for affordable housing and programs for the city's growing homeless population. The city council approved and quickly revoked the tax after Amazon threatened to halt hiring in Seattle and shift it elsewhere, highlighting yet another benefit of having a second headquarters.

The city that wins Amazon's investment — even if it offers billions — will probably get a bigger tax base, climbing wages and property values and better job opportunities , says John Boyd, principal of The Boyd Company, a corporate site selection firm in Princeton, New Jersey.

“This is the largest project in economic development history, and the city that wins Amazon will reap benefits for years,” Boyd says. “The danger Amazon faces is the longer this drags out, the greater the PR risk in this populist climate.”

By Spencer Soper; editors: Robin Ajello, Jillian Ward, Alistair Barr.

Source: https://www.businessoffashion.com/articles/news-analysis/amazons-headquarters-bidding-war-puts-it-in-corporate-welfare-spotlight

[newssplashy]

Tech: Stanford researchers are figuring out how ketamine fights depression — and why the drug has been called 'the most important discovery in half a century'

A new Stanford study is the first to illuminate how ketamine works in the brain to alleviate depression. The research suggests that the drug engages the opioid system — the same one that's activated by opioid painkillers — in addition to affecting the glutamate system.

A new study from Stanford sheds light on how ketamine works in the brain to alleviate depression.

The research suggests that the drug not only impacts a network of switches called the glutamate system, but also engages the opioid system — the same one that's activated by opioid painkillers.

The finding could have big implications for plans to turn ketamine into the next blockbuster antidepressant.

Ketamine's unique ability to staunch the symptoms of depression has earned it a new reputation in recent months. No longer seen solely as an illicit party drug, the compound is the focus of research into a novel class of antidepressants that could yield the first new depression drug in more than 30 years.

But the science of how ketamine stonewalls depression symptoms has remained murky. For years, researchers believed it worked by acting on a network of brain receptors called the glutamate system, which other popular antidepressants ignore. But a new study suggests that ketamine also influences the brain's opioid network — the same one engaged by opioid painkillers.

That could have implications for plans to turn the drug into a pharmaceutical. Drug companies including Allergan, Johnson & Johnson, and a San Francisco-based drug maker called VistaGen have all been looking to ketamine as inspiration for the next blockbuster antidepressant.

"When we say this is a new generation of drugs, we mean it. This drug is fundamentally different from all the other antidepressants that have been approved so far," Shawn Singh, VistaGen's CEO, told Business Insider in May.

The new paper, published Tuesday night in the American Journal of Psychiatry and funded by the National Institutes of Health, is the first to illuminate how ketamine exerts its effects in the brain.

Alan Schatzberg, a co-author on the paper and a professor of psychiatry at Stanford, told Business Insider that he hopes drug makers can use his team's discovery to streamline their efforts and avoid the pitfalls of antidepressant drug candidates that have failed.

"Before we did the study, I had some doubts about ketamine's use for treating depression," Schatzberg said. "Now I've seen the drug work, but I've also seen it doesn't work the way people originally thought."

How ketamine is distinct from existing depression drugs

Most existing antidepressants, from Abilify to Zoloft, work by plugging up the places where our brain takes up serotonin, a chemical messenger that plays a key role in mood. The result is more free-floating serotonin and, in some people, relief from a dark curtain of depressive symptoms.

But those effects don't occur in everyone who tries the drugs. In fact, up to 80% of the people who try existing antidepressants fail to see results. Plus, the drugs take four to six weeks to work. As a result, depression remains one of the world's leading causes of death.

Ketamine, on the other hand, affects key switches in the brain called NMDA receptors. Collectively, these switches are part of a larger network in the brain called the glutamate system. Like serotonin receptors, those for NMDA play an important role in our mood and help keep our emotions in check. But NMDA receptors also keep our brain's synapses — the delicate branches that serve as the ecosystem for our thoughts — flexible and resilient.

Depression appears to cause those synaptic branches to shrivel up and in some cases even die. Scientists think existing antidepressant drugs send help to those branches indirectly over time by way of serotonin. Ketamine, by contrast, delivers its aid directly by plugging up NMDA receptors like a cork and nipping depressive symptoms within hours.

This mechanism of action spurred some scientists to call ketamine "the most important discovery in half a century" in 2012.

The new study suggests that in addition to affecting the glutamate system, ketamine also impacts the same switches that are targeted by opioid painkillers.

For their work, the Stanford researchers gave 12 adults whose depression failed to respond to multiple treatments two infusions of ketamine. Before the first infusion, the participants took a drug that blocks the brain's opioid receptors. Before the second infusion, the participants got a placebo. (The participants and researchers were never told whether they were getting the drug or the placebo — a double-blind setup designed to minimize the chance that observed results were merely psychological.)

In more than half the cases in which the participants got the placebo, the ketamine appeared to reduce depressive symptoms by roughly 90%; the effects lasted about three days. Conversely, when the patients got the opioid-blocker before the ketamine, the ketamine had virtually no antidepressant effects.

This finding led the researchers to hypothesize that ketamine's activity takes place in different phases. In the first, the drug activates the brain's opioid receptors, quickly smothering depressive symptoms, one of the researchers suggested in the paper. In the second phase — which is thought to be key for ketamine's lasting antidepressant qualities — the drug appears to engage the brain's glutamate system.

What the next blockbuster antidepressant needs

Several drug companies have tried and failed to create a new depression drug that targets the NMDA receptors in the glutamate system. Pharmaceutical giant Roche pulled the plug on a drug called basimglurant in 2016 after it failed to show results in a Phase II study; AstraZeneca discontinued its work on a heavily-promoted candidate called lanicemine in 2013.

Yet ketamine's rapid-fire ability to stymie depressive symptoms has continued to baffle and inspire researchers looking for an alternative to current treatments.

Allergan, Johnson & Johnson, and VistaGen are all currently working to develop new ketamine-inspired drugs. In fact, two of the authors on the latest paper previously consulted for these companies: Schatzberg received a grant from Janssen, Johnson & Johnson's neuroscience partner, and study author Carolyn Rodriguez has consulted for Allergan.

None of the three drug candidates target the brain's opioid system, however.

Mark Smith, VistaGen's chief medical officer, said that although the results of the study are "intriguing," they would not directly impact the company's work on its new drug.

Similarly, a representative from Janssen, whose work with Johnson & Johnson has focused on a nasal-spray version of esketamine (the chemical mirror image of ketamine), told Business Insider in a statement that the Stanford study would not impact the direction of their work. They added that there were several issues with the study, including the fact that it was small and did not include "relevant control conditions."

But overall, the new study sheds light on important questions about why — and how — ketamine works to fight depression in the brain.

"I think this paper points us in the direction that the [opioid system] is an area for potential interest," Schatzberg said. "The question is, can we have a rational discussion about this in an era when there’s an opioid crisis?"

source http://www.newssplashy.com/2018/08/tech-stanford-researchers-are-figuring_29.html