#PEA3

[camerasarerolling]

PEA3E MSMA3PTXdDLLRM5dtdaM28A1MM5-SAXd\RL%BRBMM2L@d`ddSd\RSAMPd

☹

[rurpleplayssims]

Sims 2 Pleasantview neighbourhood based story, set a couple of years after the original maxis timeline. Bella has mysteriously reappeared, Dina has boycotted the Goths, Daniel Pleasant's about to have breakdown, Don's loving life, Kaylynn is conflicted, Angela is scheming, Lilith is angry and Brandi is still mourning. And the Oldies are just chilling.

Chapter One here: Lilith Pleasant (Part 1) Chapter Two here: Lilith Pleasant (Part 2) Chapter Three here: Kaylynn Langerak (Part 1) Chapter Four here: Dina Caliente-Goth (Part 1) Chapter Five here: Kaylynn Langerak (Part 2) Chapter Six here: Dina Caliente-Goth (Part 2- Tumblr Voted) Chapter Seven here: Lilith Pleasant (Part 3) Chapter Eight: Angela Pleasant (Part 1)

Chapter Nine: (THIS STORY IS CURRENTLY ON HIATUS)

Enjoy and thank you for all support and comments!

[m0e-ru]

watching a ten hour pea3 digest on 4x speed bc i dont have the energy to play and i burn four hours in two hours i feel. insane

[julieterbang]

pea3e

[epigen-papers]

FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination.

Pubmed: http://dlvr.it/QjQH2M

[cancersfakianakis1]

A double-edged sword: the world according to Capicua in cancer

Abstract

CIC/Capicua is a HMG-box transcription factor that is well conserved during evolution. CIC recognizes the T(G/C)AATG(A/G)A sequence and represses its target genes such as PEA3 family genes. The RTK/RAS/MAPK signals downregulate CIC and relieves CIC's target genes from the transrepressional activity, and CIC thus acts as an important downstream molecule of the pathway and as a tumor suppressor. CIC loss-of-function mutations are frequently observed in several human neoplasms such as oligodendroglioma, and lung and gastric carcinoma. CIC is also involved in chromosomal translocation-associated gene fusions in highly aggressive small round cell sarcoma that is biologically and clinically distinct from Ewing sarcoma. In these mutations, PEA3 family genes and other important target genes are upregulated, inducing malignant phenotypes. Downregulation of CIC abrogates the effect of MAPK inhibitors, suggesting its potential role as an important modifier of molecular target therapies for cancer. These data reveal the importance of CIC as a key molecule in signal transduction, carcinogenesis and developing novel therapies.

This article is protected by copyright. All rights reserved.

http://ift.tt/2y0TBLP

[eurekamag--com]

Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools

http://dlvr.it/NKDHZ9

[rurpleplayssims]

THIRD CHAPTER of my Sims 2 story ‘Pleasant(ly) Ever After..?’ is up over at Blogger!

Read it here!

Longer chapter this time as I needed to reshoot the pictures twice by accident! Apologies for the long wait. AND I'm sorry because in the previous tumblr post I said I was stopping for the night but I wanted to get this uploaded whilst I was feeling inspired!

*WARNINGS: Swearing, Sims in Underwear and mention of extra martial affair.*

[cancersfakianakis1]

CIC-DUX4 induces small round cell sarcomas distinct from Ewing sarcoma

CIC-DUX4 sarcoma (CDS) or CIC-rearranged sarcoma is a subcategory of small round cell sarcoma resembling the morphological phenotypes of Ewing sarcoma (ES). Hoever, recent clinicopathologic and molecular genetic analyses indicate that CDS is an independent disease entity from ES. Few ancillary markers have been used in the differential diagnosis of CDS, and additional CDS-specific biomarkers are needed for more definitive classification. Here we report the generation of an ex vivo mouse model for CDS by transducing embryonic mesenchymal cells (eMC) with human CIC-DUX4 cDNA. Recipient mice transplanted with eMC expressing CIC-DUX4 rapidly developed an aggressive, undifferentiated sarcoma composed of small-round to short-spindle cells. Gene expression profiles of CDS and eMC revealed upregulation of CIC-DUX4 downstream genes such as PEA3 family genes, Ccnd2, Crh and Zic1. Immunohistochemical analyses for both mouse and human tumors showed that CCND2 and MUC5AC are reliable biomarkers to distinguish CDS from ES. Gene silencing of CIC-DUX4 as well as Ccnd2, Ret, and Bcl2 effectively inhibited CDS tumor growth in vitro. The CDK4/6 inhibitor palbociclib and the soft tissue sarcoma drug trabectedin also blocked the growth of mouse CDS. In summary, our mouse model provides important biological information about CDS and provides a useful platform to explore biomarkers and therapeutic agents for CDS. http://ift.tt/2paB36G

[eurekamag--com]

ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools

http://dlvr.it/N7cQHh