#Neurohormones

[superpte]

What’s Life For? Enslavement to Neurohormones?

It turns out, surprisingly enough, that this question is eminently practical. And eminently varied. Great religions have given various answers made to be imposed on all… Because those answers pleased the authorities. Neurobiology can help with new dimensions of understanding the past did not have. A Lieutenant Colonel of the IDF sat alone, for quite a while, with the dead head of Hamas, Sinwar.…

[iocheaira]

silliest part of the post run endorphins is the anti dysphoria effect. objectively i look exactly the same but psychologically i think im the coolest shit

[caesarsaladinn]

I took a break from biology and am now realizing how terrible the citation system is:

Neuropeptides are a diverse group of signaling molecules that play a crucial role in the function of the nervous system in most metazoan animals (Hökfelt et al. 2000; Grimmelikhuijzen et al. 2002; Jékely 2013; Mirabeau and Joly 2013; Roch and Sherwood 2014). These signaling molecules do not only mediate by direct synaptic transmission but mostly transfer signals by volume transmission as neurohormones or neuromodulators and, thus, play important roles in the modulation of neural circuits (Christie et al. 1995; Nassel and Winther 2010; Catak et al. 2014; Diao et al. 2017; Senatore et al. 2017; Williams et al. 2017; Jékely et al. 2018).

illegible! use footnotes.

[polyphonetic]

My mech just bought me a "Trophy Pilot" croptop to wear when my neurohormonal responses are plugged into him

[sorrowandpride]

Listen, I know that medical misogyny is a huge thing with a deep history, and people do blame women's valid reactions to oppression and abuse on our menses.

HOWEVER, to not only claim, but also ARGUE, that menstrual conditions like PMS, PMDD, and menstrual psychosis have no biological reality and are simply the result of misogyny IS medical misogyny.

Not everyone's neurological system reacts the same to fluctuations in female sex hormones, especially if they're neurodivergent (PMDD, for example, has a much higher incidence in people with autism and/or ADHD). While I understand the fear of creating a new hysteria, disregarding women's very real ailments as socially constructed does just that.

Women have literally taken their own lives because of PMDD, and the notion that it has no biological reality is both heartbreaking and infuriating, ESPECIALLY when it's perpetuated by fellow women. If a person's symptoms consistently occur at the same time in their menstrual cycle, that alone suggests a neurohormonal etiology.

While many things are caused/influenced/exacerbated by socioeconomic factors, not everything has a socioeconomic cause. Living in a world with complete equity will not eliminate all disorders, and there's no shame in admitting that biology is not perfect. There's also no shame in requiring psychiatric and/or hormonal medications to treat a condition, and I'm absolutely sick and tired of the notion that social change and healthy living will cure everything. I consistently take vitamins, exercise, and make my meals from scratch. However, I still need medication to suppress ovulation and my menstrual cycle to function. In my (and many others') case, supplements don't do shit as treatment.

[distracteddaintydemon]

Silly Game Time: You get to choose one superpower. Which do you pick, and why?

Oh, and incidentally, I will be picking one thematically related weakness/caveat to your power. But don't worry about that; I am trustworthy and not at all nefarious. >:)

Oooh, this is a tricky one!

Mostly because I tend to think about superpowers in packages. Synergies are the best. So choosing only one is extremely hard.

I could just pick one from my favorite bundled package, or something classical, but it would be too easy. No. If I'm to choose one and one only, I'm going to present something standalone, intricate and elegant.

I'm choosing Neurohormonal Precognition. As in, I can tell current balance of hormons and neurotransmitters in any given person in my vicinity (including me), and if I choose to give it some thought, I can learn conditions to push that balance in different direction.

And once I learn these conditions, I can act upon them or not, in the way any person without superpowers could.

Once I know the right words to lower someone's momentary cortisol level, no superpowers are needed to say them. When I see someone is overstressed by loud mall music, I can learn that their comfort food will help and what it is, but I don't have additional superpower to turn music down or to make them less vulnerable to mall music. Talking with barely-conscious student at morning, I can know that coffee won't help but some sugary food with coffee will, but I don't have any additional power to convince them.

Of course, I also know the best course of action to piss off every given person out of their mind. If I want to know.

How do you like my Neurohormonal Precognition?

[aish-thinks]

ASMR, ASMR, ASMR!

Be it Instagram or YouTube, one incredibly common thing we find these days is ASMR audios and videos. There are documentaries made with heavy crowd fundings and films too (Tertiary Sound, Shut Eye). What is this ASMR? Why is it always on trend?

Autonomous Sensory Meridian Response is abbreviated as ASMR. Often confused to sexual arousal, ASMR is a non-sexual response associated with tingling sensation which starts from center of the brain and extends towards spine and limbs. Jennifer Allen explained this better by describing each term.

Autonomous – spontaneous, self-governed, controlled or uncontrolled

Sensory – all about sensation and senses

Meridian – highest point of development, signifying a peak or climax

Response – refers to an experience triggered by an internal or external source

Let me simplify, did you ever experience any stimulation while having a haircut, gentle shampooing by the stylist or when a masseur is massaging especially foot or flipping through a magazine or crinkling paper, licking sounds, nail tapping sounds, stirring a bowl with liquid food or any subtle movements? And the aftereffect of this experience is peace, relaxation and contentment, then that response is an ASMR. It is scientifically supported that, it reduces headache, calms mind, therapeutic for depression, anxiety and insomnia.

Still the studies are being continued, ASMR is assumed to have connections with Autonomous Nervous System (ANS) and release of neurohormones like dopamine, oxytocin and endorphins. Interestingly, not everyone has pleasant experiences with ASMR, some find it stressful and irritating while for some, there’s no effect. ASMR creates positivity, helps mental healing, puts us to sleep, things every one of us need and crave for and this satisfactorily supports the hype around ASMR.

[bean-pronounced-bawn]

My pathophysiology textbook follows a pretty standard pattern in each chapter. Module 1 is The Topic, module 2 is What Happens When The Topic Gets Fucked Up, then module three is Clinical Models of The Topic. Each clinical model also follows a pattern, where is goes over the pathophysiology of the disease, the clinical manifestations of the disease, the diagnostic process, and treatment.

One of the chapters for this week is altered nutrition, so module 1 talked about macro/micronutrients and how digestion and absorption works, and module 2 talked about undernutrition, malabsorption, allergies, and overnutrition. In the clinical models, along with things like a.norexi.a nervosa, iron deficient a.nemia, and p.henyketonuria, they talked about o.besity. And I thought it was wild how they managed to call o.besity a disease while not giving anything to show how it's a disease.

As expected, they called it a concerning epidemic yada yada, and then in the pathophysiology section they basically explained the mechanisms of fat storage and said that ob.esity is a complex multifactorial condition where genetics influence 1/3, neurohormonal messages and hormones play a major role, and lifestyle factors (they talked about socioeconomic status and environmental factors involved, which was nice ig bc I 100% expected it to be just "these people eat too much"...). Which, yeah, that's how fat storage works and what influences it, but that doesn't tell me anything about how it's a disease. Compare that to anemia, where they talked about how iron is requires for hemoglobin synthesis and electron transport, and how deficiency is more common in people who menstruate (the book confuses female/woman, so they say women, but whatever) because of blood loss, and how a lack of iron directly leads to chronic hypoxia resulting in lack of function of organs like the heart and skin and brain and such. For o.besity, other than "people are fat," they give nothing for how this constitutes a disease.

Then in the clinical manifestations, they say "excess body fat" (wow), and then talk about comorbidities, some of which I know from other class research projects have been shown to have no statistically significant correlation to weight (joint issues). While these may be influenced by being fat, none of these are inherent aspects of being fat the way hypoxia is an inherent aspect of anemia. You can be class 3 o.bese and never have any of these problems. You cannot be clinically anemic and not eventually experience hypoxia (anemia has slow onset symptoms as tissues go longer without adequate oxygen, so you can be diagnosed without symptoms if it gets caught early or isn't clinically significant). That's like saying being female is a disease because there's a correlation between autoimmune conditions and the female sex, thereby making autoimmunity a comorbidity of being female. Like, you can say being female is a risk factor to developing autoimmunity, and you can say being fat is a risk factor to developing these conditions, but it's weird to say it's a disease on its own.

The diagnostic criteria talked about BMI uncritically and talked about diagnosing the comorbidities, which, whatever. We knew they had nothing to say about being fat itself. Then in the frickin treatment section, after having the whole conversation about all the different factors that go into being fat and how complex of a condition it is with multiple etiologies, they talk about drugs that suppress appetite, and diet and exercise as a treatment. (Along with chopping off your frickin stomach and all that fun stuff). Aside from the fact that diet and exercise doesn't result in long-term weight loss and that short term weight loss results in more long -term regain and that weight yoyoing has stronger frickin correlations to all the comorbidities than weight-maintained o.besity does, they literally said that lack of diet and exercise is a small part of weight determination and then said "well if you diet and exercise you'll stop being fat 🤪✌️."

Like, not only did they directly contradict themselves, but they have given me no reason to think o.besity should be considered a disease. The one thing that they could have expanded upon was that adipocytes modulate pro-inflammatory cytokines (they promote inflammation), but they didn't talk about it beyond one sentence, so I don't know how that impacts body systems. Does it trigger inflammation? Are fat people in a perpetual state of immune response? Does it damage nearby tissues? How so? Does it increase the response-ability of the immune system, leading to increased risk of overreaction? Does it increase stress signals like cortisol, leading to the whole cascade of damage that cortisol is known to cause? We'll never fucking know because the only concrete potential evidence of the damage ob.esity might cause was part of one sentence.

[neotia-getwel]

What is the pathophysiology of congestive heart failure?

Pathophysiology of Congestive Heart Failure (CHF):

Congestive heart failure (CHF) is a condition where the heart is unable to pump blood effectively, leading to inadequate blood flow to the body and fluid buildup in the lungs and other tissues. The pathophysiology involves several interconnected mechanisms:

Reduced Cardiac Output: CHF occurs when the heart's pumping capacity (either due to weakened heart muscle or stiffened heart walls) is insufficient to meet the body’s needs, leading to a reduction in cardiac output.

Increased Preload: When the heart cannot pump effectively, blood backs up in the veins (particularly in the lungs in left-sided heart failure) and increases the volume (preload) that the heart has to pump.

Neurohormonal Activation: The body responds to reduced cardiac output by activating compensatory mechanisms like the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. This increases blood pressure and fluid retention, which further strains the heart and worsens heart failure.

Ventricular Remodeling: Chronic stress on the heart causes changes in the structure and function of the heart muscle, known as remodeling. This may involve dilation of the ventricles, thickening of the heart walls, and fibrosis, making the heart less efficient.

Fluid Retention: The kidneys respond to reduced blood flow by retaining salt and water, which worsens fluid buildup (edema) in tissues, leading to symptoms like swelling in the legs and shortness of breath (due to pulmonary congestion).

Decreased Ejection Fraction: In systolic heart failure, the heart's ability to contract is impaired, leading to a low ejection fraction (EF). In diastolic heart failure, the heart’s ability to relax and fill with blood is impaired, often with a preserved EF but reduced overall filling capacity.

These factors lead to a vicious cycle that worsens heart failure symptoms over time, contributing to fluid buildup in the lungs (pulmonary edema) and peripheral tissues (such as in the legs, abdomen, and liver).

If you're concerned about CHF symptoms or diagnosis, it's important to consult healthcare professionals, such as those at Neotia Getwell Multispecialty Hospital, for a comprehensive evaluation and management plan tailored to your condition.

[superpte]

Stress Prepares For Fight, Flight, Heroism, Great Feats & Utmost Mental Nobility... But Stress Is Counterindicated To Slaves

Is Stress as bad as its repute? Does one get addicted to it? And why? Why stress? Does stress have a good side? Is stress inherent to the mental creation process? (Yes it is!) “Stress” as a word is very old, but the modern notion of stress as a psychological condition is very recent. I reckon that this has to do with the state of the world. The word “stress” comes from Old French estrece from…

[santaispa]

How We Offer the Best Russian Massage in Dubai Center

Russian massage treatment was created in the former USSR and is used in both sporting and therapeutic settings. It accomplishes this by manipulating the body's soft tissues with a variety of techniques, which lessens tension and eases soreness in the muscles. Numerous societies worldwide have evolved distinct forms of massage therapy. The Greek physician Hippocrates, who is regarded as the father of medicine, was among its earliest proponents. Many people think that Per Henrik Ling, a Swedish physician, invented contemporary European massage in the 1800s. Ling vigorously rubbed to promote lymphatic and circulatory flow. In Russia, massage was not systematically studied or applied until 1860. Following World War II, when medications were scarce, treatment techniques were improved.

Physiatrists, or physicians with advanced degrees in physical therapy, were employed by the Soviet Union to investigate the potential advantages of complementary therapies. To help in the stimulation of new muscle growth and the reversal of muscular atrophy, they created a type of petrissage. According to Russian physiologists, neurohormone and neuroendocrine responses are the source of all massage movements. Russian massage, in contrast to other forms of massage, focuses more on treating the problem's physiology than its anatomy. Water-softened oak (or birch) branches are used by two venik practitioners to "hit" face-down clients in a gentle and rhythmic manner. The collisions and friction of these branches heat the body and enhance circulation. In recent decades, there has been a growing interest in this unusual type of massage therapy from both Russians and non-Russians.

In our Russian steam baths known as "banyas," venkarma procedures are offered

Before receiving a massage, many clients like to relax in steam rooms, take hot baths, and then dive into cold water pools. It's likely that people started doing this customary way of life to get used to the brutally cold Russian winters. Many others, however, favor a more contemporary kind of massage that originated in the same area. Modern Russian massage, which was developed in the former Soviet Union and brought to Russia in the 1800s, shares certain parallels with reflexology, point massage, and sports massage. Our dubai russian massage center increases immunity, facilitates breathing, and enhances neurological system performance.

Compared to their counterparts in the sports massage industry, Russian massage therapists work more slowly and gently. They promote circulation and generate heat in their clients' bodies by generating friction. In addition, Russian massage therapists use methods like vibrating, slapping, and kneading to release tension in the soft tissues, including the muscles.Russian doctors blended conventional medicine with massage techniques during the 20th century; this combination was frequently called "manual therapy," even by those serving on the front lines of World War II. Throughout the Soviet era, massage therapy treatments were actually exclusively available to athletes and medical patients.

Our dubai russian massage center is increasingly widely used by patients as a supplement to other forms of therapy and medical attention. It can expedite the recovery from trauma and the healing of various illnesses. To find out if this type of massage will improve your health, lessen symptoms, or limit adverse effects, speak with us.

[cavenewstimes]

Scientists discover how starfish get 'legless'

Researchers at Queen Mary University of London have made a groundbreaking discovery about how sea stars (commonly known as starfish) manage to survive predatory attacks by shedding their own limbs. The team has identified a neurohormone responsible for triggering this remarkable feat of self-preservation. Autotomy, the ability of an animal to detach a body part to evade predators, is a…

[sunfoxtech]

What is the Heart Failure

Heart failure is a complex clinical syndrome that arises when the heart is unable to pump sufficient blood to meet the body's metabolic demands. This insufficiency is often due to structural or functional impairments, such as those caused by ischemic heart disease or hypertension, leading to reduced cardiac contractility. The immediate consequence is a decrease in the heart's ability to effectively circulate blood, resulting in symptoms such as fatigue, shortness of breath, and fluid retention.

In response to declining cardiac output, the body activates compensatory mechanisms, including the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS). Initially, these mechanisms help to maintain blood pressure and perfusion by increasing heart rate and fluid retention. However, chronic activation of these systems leads to detrimental effects, such as increased afterload and fluid overload. This prolonged stress on the heart contributes to further deterioration of cardiac function and exacerbation of heart failure symptoms.

Moreover, the chronic activation of neurohormonal pathways and the release of inflammatory cytokines play a significant role in the progression of heart failure. These factors promote myocardial damage and fibrosis, resulting in adverse cardiac remodeling. Over time, this remodeling process impairs the heart's ability to pump efficiently, leading to a vicious cycle of worsening heart function and symptoms. Understanding these pathophysiological mechanisms is crucial for developing effective treatments and management strategies for heart failure.

[sanetimental]

The Stigma Surrounding Addiction in Developing Countries

Explore the pervasive stigma surrounding addiction in developing countries and discover the importance of empathy and compassion in dismantling barriers and challenging negative beliefs.

Introduction: The Importance of an Empathetic and Compassionate Approach In my third year of pre-clinical studies, I had to write a research paper in Biochemistry on nicotine addiction with emphasis on the brain pathways and neurohormonal mechanisms involved. It was an interesting study to conduct, but in retrospect, my biases still tainted my perspectives on cigarette addiction. In my immediate…

[elixir-ayurveda]

Ayurvedic Treatment in Trivandrum: The Synergistic Dance of Ayurveda and Yoga

In the vibrant landscape of Trivandrum, Ayurvedic treatment in Trivandrum thrives as an embodiment of holistic well-being. Here, Ayurveda and Yoga form a remarkable union, two sciences harmonizing to unlock the secrets of health. Ayurveda, the guardian of both physical and mental vitality, partners with Yoga, the guardian of mental health. The practice of Yoga offers a preventive and therapeutic embrace that guides the body's neurohormones and metabolism back into their natural rhythm, enhancing endocrine functions. This symbiotic relationship provides a profound defense against stress and its related afflictions, nurturing holistic rejuvenation at the heart of Trivandrum.

[mnrpardiman]

Octopamine (molecular formula C8H11NO2; also known as OA, and also norsynephrine, para-octopamine and others) is an organic chemical closely related to norepinephrine and synthesized biologically by a homologous pathway. Octopamine is often considered the major "fight-or-flight" neurohormone of invertebrates. Its name is derived from the fact that it was first identified in the salivary gland of the octopus.