#Neurodegenerative

[biopharmaceuticalindustry]

FROM DISCOVERY TO DELIVERY: Neuronal exosomes and the evolution of neurodegenerative disease treatment

Neuronal exosomes are revolutionising neurodegenerative disease management. They are unlocking new treatment avenues in diagnostics, drug development, and clinical trial management. This work explores innovative, personalised approaches, transforming traditional challenges into opportunities for enhanced neurological care.

Discover more: https://www.pharmafocusasia.com/research-development/from-discovery-to-delivery

[bespokebiologix]

Understanding Neurodegenerative Diseases: Causes, Symptoms, and Treatment Options

Neurodegenerative diseases, characterized by the progressive loss of brain cells, are a growing global health concern. These conditions can significantly impact a person's quality of life and often lead to disability. This blog post will explore the causes, symptoms, and potential treatment options for neurodegenerative disorders, focusing on the promising field of regenerative stem cell therapy.

Common Neurodegenerative Diseases

Several neurodegenerative disorders affect millions of people worldwide. Some of the most well-known include:

Alzheimer's disease: Characterized by memory loss, confusion, and difficulty with tasks.

Parkinson's disease: Associated with tremors, rigidity, and slow movements.

Multiple sclerosis (MS): An autoimmune disorder affecting the central nervous system, leading to symptoms like numbness, weakness, and vision problems.

Amyotrophic lateral sclerosis (ALS): A progressive disease that affects motor neurons, causing muscle weakness and atrophy.

Prion Disease: Prion diseases are a rare and fatal group of conditions caused by misfolded proteins that accumulate in the brain. These diseases can lead to severe brain damage and rapid deterioration. Creutzfeldt-Jakob disease is the most common type of prion disease and typically occurs for unknown reasons. In some cases, prion diseases can be inherited, with a longer survival time between one and ten years.

How common are Neurodegenerative brain diseases?

Neurodegenerative disorders are a significant global health concern. While their prevalence varies depending on specific conditions and geographic regions, they affect millions worldwide.

Here are some statistics:

Alzheimer's disease: The most common neurodegenerative disease, affecting an estimated 50 million people globally.

Parkinson's disease: Approximately 10 million people worldwide are living with Parkinson's disease.

Multiple sclerosis: MS affects around 2.8 million people globally.

Amyotrophic lateral sclerosis: ALS is a rare disease, with an estimated 5-10 cases per 100,000 people.

Causes of Neurodegenerative Diseases

The exact causes of many neurodegenerative diseases remain unknown. However, several factors are thought to contribute, including:

Genetics: Some diseases have a strong genetic component.

Environmental factors: Exposure to toxins or certain lifestyle factors may increase the risk.

Protein misfolding: Abnormal protein aggregation can damage brain cells.

Inflammation: Chronic inflammation in the brain can contribute to disease progression.

Symptoms of Neurodegenerative Disorders

Symptoms of neurodegenerative diseases can vary depending on the specific condition. However, common symptoms often include:

Cognitive decline: Memory loss, difficulty concentrating, and confusion.

Motor problems: Tremors, muscle weakness, difficulty walking, and coordination issues.

Sensory changes: Numbness, tingling, or vision problems.

Emotional disturbances: Mood swings, depression, and anxiety.

Motor neuron diseases: It affects parts of your brain and nervous system that are responsible for muscle control. As the neurons in those areas die, you lose muscle control. That causes weakness and, eventually, paralysis.

Treatment Options

While there is currently no cure for most neurodegenerative disorders, various treatments can help manage symptoms and improve quality of life. These may include:

1. Medication

Disease-specific: Medications can target the underlying causes or symptoms of specific diseases. For example, levodopa is used to treat Parkinson's disease by increasing dopamine levels.  

Symptom management: Medications can help alleviate pain, tremors, or cognitive decline.  

2. Therapy

Physical therapy: Can help improve mobility and strength.  

Occupational therapy: Can assist with daily living activities.  

Speech therapy: Can aid in communication difficulties.  

Cognitive therapy: Can help manage cognitive changes and improve memory.  

3, Lifestyle modifications

Healthy diet: A balanced diet can support overall health and well-being.  

Regular exercise: Physical activity can help maintain muscle strength and improve mood.  

Stress management: Techniques like meditation or yoga can reduce stress and anxiety.

4. Supportive care

Home care: Assistance with daily tasks can help individuals maintain independence.  

Hospice care: Provides comfort and support for individuals in the advanced stages of the disease.

5. Emerging Therapies

Stem cell therapy: Research is exploring the potential of stem cells to repair damaged brain tissue.  

Gene therapy: This involves introducing healthy genes to replace defective ones.  

Deep brain stimulation involves implanting electrodes into the brain to stimulate specific areas.

Regenerative Stem Cell Therapy: A Promising Approach

It has emerged as a potential treatment for neurodegenerative diseases. Stem cells are undifferentiated cells that can develop into various cell types, including neurons. By introducing stem cells into the brain, researchers hope to stimulate the growth of new neurons and repair damaged tissue.

Conclusion

Neurodegenerative disorders are a significant health challenge, but ongoing research and advancements in treatment options offer hope for the future. While current treatments can help manage symptoms, regenerative stem cell therapy holds promise as a potential breakthrough in the field. As research progresses, we may be closer to developing effective therapies that can slow or even reverse the progression of these debilitating diseases.

[maisha-online]

Parkinson's Disease: A Promising Breakthrough for Halting Disease Progression

Parkinson's Disease: A Promising Breakthrough for Halting Disease Progression #ParkinsonsDisease #USP30 #Dopamine #Neurodegenerative

Parkinson’s disease (PD) is a neurodegenerative disorder that affects millions of individuals worldwide. It is characterized by the progressive loss of dopamine-producing neurons, leading to a decline in dopamine levels and a range of symptoms including tremors, stiffness, and difficulties with movement and coordination. Despite extensive research, there has been a lack of disease-modifying…

[andebonn]

'Rugby'

[dementiaxx]

The Most Common Cause of Dementia: Alzheimer's Disease

Dementia is a condition that affects many people around the world, and the most common cause of dementia is Alzheimer's disease. In this blog post, we will discuss what Alzheimer's disease is, how it affects individuals and society, and the ongoing efforts to support and find solutions for this condition.

Understanding Alzheimer's Disease: Alzheimer's disease is a progressive brain disorder that gradually affects a person's memory and thinking abilities. It is the leading cause of dementia, accounting for about 60-70% of all dementia cases. While it mainly affects older adults, there are instances of early-onset Alzheimer's disease occurring in individuals younger than 65.

Symptoms and Progression: The initial signs of Alzheimer's disease are often subtle memory loss and difficulty remembering recent events or conversations. As the disease progresses, individuals may struggle with language skills, decision-making, and problem-solving. They might also experience confusion, disorientation, mood swings, and changes in their personality.

The underlying cause of Alzheimer's disease involves the build-up of abnormal protein structures called amyloid plaques and tau tangles in the brain. These deposits disrupt communication between brain cells, leading to their degeneration and eventual cell death.

Impact on Individuals and Society: Alzheimer's disease not only affects individuals diagnosed with the condition but also has a significant impact on their families and caregivers. As the disease progresses, individuals require increasing assistance with daily activities and may eventually need full-time care. This places emotional, physical, and financial burdens on families, affecting their quality of life.

Furthermore, Alzheimer's disease has a broader impact on society. The costs associated with healthcare, caregiving, and lost productivity are substantial. With the aging population, the prevalence of Alzheimer's disease is expected to increase, highlighting the urgent need for research, prevention strategies, and improved care approaches.

Current Research and Support: Researchers are actively studying Alzheimer's disease to gain a better understanding of its mechanisms and develop effective treatments. They are exploring various approaches, including immunotherapy, genetic risk factors, lifestyle interventions, and early detection methods. Advances in brain imaging and biomarker research offer hope for earlier diagnosis and intervention.

Support for individuals with Alzheimer's disease and their caregivers is crucial. Many organizations provide resources, support groups, and educational materials to help individuals navigate the challenges associated with the disease. These resources aim to improve the quality of life for affected individuals, support caregivers, and raise awareness about Alzheimer's disease.

Conclusion: Alzheimer's disease is the most common cause of dementia worldwide, affecting millions of individuals and their families. While there is currently no cure, ongoing research efforts offer hope for a better understanding, earlier detection, and innovative treatments. Additionally, providing support and increasing awareness about Alzheimer's disease are essential to improve the lives of those affected and reduce the burden on families and caregivers. By working together, we can strive for a future where effective treatments and preventive strategies help mitigate the impact of this devastating disease

[nycannabistimes]

#Repost @cannabasic_ ・・・ There is obviously a certain context to every memory that takes place in an individual’s life that reminds them of those events, including the traumatic ones. Similarly, individuals who get diagnosed with PTSD also experience a traumatic event within a certain context. Could be a certain sound, visual or a particular smell, that reminds him or her of the aversive event that took place. In other words, generally, people are conditioned to associate a certain context to the memory of the event that took place by the triggering of flashbacks. This is called fear conditioning. Normally, most people who are conditioned by a certain trigger become deconditioned to it after the trigger appears frequently in the abstinence of the event that caused fear conditioning, leading to fear extinction. In PTSD patients however, the fear extinction is not achieved, due to the “hyperactivity” and impaired ECS activity in the amygdala of the brain. Amygdala is a region in the brain responsible for experiencing fear, fear conditioning, and fear extinction. Research has shown that CB1 receptors of the endocannabinoid system in the amygdala are less active in PTSD patients, which may very well be the reason of impaired fear extinction. . . . . Read more- Link in Bio #canna #cannacurious #cannabisscience #cannabinoidscience #terpenes #terpenes #terpenescience #cannabinoid #amygdala #fear #ptsd #cannabisandptsd #cannabisandneurology #cannabisandbrain #cannabisandptsd #neurodegenerative (at Immersive Van Gogh NYC) https://www.instagram.com/p/CoU3eVWOMQ_/?igshid=NGJjMDIxMWI=

[newsfromstolenland]

There’s a renewed call for a public inquiry into why so many New Brunswickers have come down with neurodegenerative symptoms and illnesses.

When an initial cluster of over 40 people presented with similar symptoms – muscle spasms, atrophy and progressive dementia – it was thought to be Creutzfeldt-Jakob disease, until they tested negative.

That’s when a Moncton-based neurologist thought they could be experiencing an unknown brain disease. The cluster was initially focused in the Moncton and Acadian Peninsula areas of the province.

But after over a year of confusing back-and-forth for patients and their families, the province of New Brunswick halted further investigation by its federal counterparts, saying there was an explanation for each patients’ illness.

This week, New York Times Magazine released an article that calls that into question, citing that neurologist Dr. Alier Marrero believes the number of people seeking help with similar symptoms is now over 400.

It has sparked Green Party MLA Megan Mitton to call for a public inquiry into what happened internally between the province and Ottawa, as well as further testing, including environmental, to try and find patients some answers.

Full article

Tagging: @allthecanadianpolitics

[laureala]

AMELIA SHEPHERD

— in Grey's Anatomy 20.01 - We've Only Just Begun

You told me to say whatever's in my- I'm sorry! It's making me think that maybe Meredith isn't insane.

[mindblowingscience]

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain. A team of researchers has found potential ways to interrupt this process by targeting “sticky” sites along the long form of mutated tau, preventing the misfolding and spreading of the neurofibrillary tangles.

Continue Reading.

[ohno-the-sun]

Woot woot more mad scientist au doodles! 

Credit to @oobbbear​ 

Another doodle under the cut (its my favorite but its gory so be warned)

[swinging-stars-from-satellites]

having a hypochondriac moment pray for me babes

[stuckinapril]

My forever struggle is that I’m in love with both neuroscience and medicinal/organic chemistry and I’m just insane enough to be double dipping in both constantly

[bpod-bpod]

Mutation Walk

Discovery of a novel gene mutation associated with the inherited nervous system disease CMT; a fruit fly model with the mutation has gait problems reflecting those of CMT patients and reveals the molecular mechanisms underlying the peripheral nerve degeneration

Read the published research article here

Video from work by Jui-Yu Yeh and colleagues

Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in EMBO Molecular Medicine, April 2024

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[faaun]

LOVELY DAUGHTER UNSOUND MIND!

[verso-sera]

Ogni volta che mi dicono che non posso fare qualcosa, scelgo di raggiungere meraviglie.

[orbees]

ppl on here are way too comfortable joking about dementia like i thought yall were against ableism.