#NatureComms

[insurgentepress]

Arrojan nanoestructuras del fondo marino sobre origen de la vida

Un artículo publicado en @NatureComms reveló que las nanoestructuras inorgánicas halladas en respiraderos hidrotermales de las profundidades oceánicas son sorprendentemente similares a las moléculas que hacen posible la vida tal como la conocemos.

Agencias/Ciudad de México.- Nanoestructuras inorgánicas halladas en respiraderos hidrotermales de las profundidades oceánicas son sorprendentemente similares a las moléculas que hacen posible la vida tal como la conocemos. Estas nanoestructuras se autoorganizan y actúan como canales iónicos selectivos, que crean energía que se puede aprovechar en forma de electricidad, según investigadores…

[mariebenz]

Inflammation Leads to Epigenetic and Metabolic Changes that Benefit Cancer. 

MedicalResearch.com Interview with:

Royce Zhou Royce Zhou, MD/PhD Candidate Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Response: The background of this story is to see whether things outside of the cancer cell, such as the tumor microenvironment, can lead to epigenetic changes within the cancer cell. These changes are largely believed to be due to factors inside the cell, not outside. Super-enhancers are the top 1-2% of enhancers in the genome. They control cell identity genes and oncogenes in cancer. MedicalResearch.com: What are the main findings? Response:  Using patient samples, we find that the tumor microenvironment can form super-enhancers within cancer cells. One formed super-enhancer regulates a gene called PDZK1IP1 which is poorly understood. We show this gene is important for colorectal cancer tumor growth. MedicalResearch.com: What should readers take away from your report? Response: Inflammation leads to epigenetic and metabolic changes that benefit cancer. MedicalResearch.com: What recommendations do you have for future research as a results of this study? Response: The use of patient specimens allows for more robust identification of epigenetic changes in cancer. This super-enhancer would not have been found using colorectal cancer cell lines, only primary tumors. In cancer cell lines, the regulated gene PDZK1IP1 is silenced. No disclosures. For Ramon Parsons' disclosures, please see here: R.E.P. owns equity in Therapten. Ramon Parsons receives royalty payments from Cullgen and Therapten. R.E.P. gives industry-sponsored lectures at the Lurie Cancer Center and the University of Southern California Cancer Center. R.E.P. reports other activities with Columbia University and Regeneron Pharmaceuticals. Citation: Royce W. Zhou et al, A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma, Nature Communications (2022). DOI: 10.1038/s41467-022-33377-8 The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.     Read the full article

[pandemic-info]

42% of people who had a symptomatic SARS-CoV-2 infection reported feeling only partially recovered between 6- and 18-months following infection, according to a study published in @NatureComms.

https://www.nature.com/articles/s41467-022-33415-5

[sunburs2015]

Tweet from @EnvDSbook

Enjoy the research on #seaice as it dissapears at the #poles. Hard work earned #Grammy awards for these dudes https://twitter.com/EnvDSbook/status/1510959799948697606 @EnvDSbook: Discover the full details of the forecasting system in the #IceNet #openaccess paper which has been included into the top 25 most read @NatureComms articles in the Earth Sciences category last year #NCOMTop25🏅…

[samantilla]

Costo social del carbón

Estimado(a) amigo(a):

Nuevo post hoy en samuelmantilla.com:

Costo social del carbón. Una oleada nueva a la cual el mundo contable tendrá que incorporarse

El cambio climático, en particular, y la sostenibilidad, en general, están en el primer lugar de la agenda de las decisiones de política general (macroeconómica) y están siendo incluidos en la agenda de las decisiones empresariales.

En términos de información financiera (preparación, presentación, revelación, control interno, auditoría y aseguramiento) constituyen una ola que está llegando con fuerza. En un futuro cercano se vislumbran los ‘IFRS/NIIF para la sostenibilidad’.

Sin dudas, los reportes empresariales de sostenibilidad son ‘la próxima oleada’ a la que el mundo de los contadores deberá incorporarse. Ojalá con celeridad. En esa dirección avanzan los procesos que está desarrollando la Fundación IFRS alrededor de estándares de sostenibilidad para la ‘creación de valor’.

El análisis, realizado por Samuel Mantilla, puede verlo en: https://www.samuelmantilla.com/post/costo-social-del-carb%C3%B3n

@kmac, @naturecomms, @DannyBressler1

Atento saludo

[superpruchika99world]

Covishield single jab efficacy drops after 16 weeks in 60+ age grp: Report

Coronavirus News The efficacy of the single dose of Oxford-Astrazeneca COVID-19 vaccine Covishield dropped at 16 weeks for those above the age of 60, while 93 per cent of the younger population showed very good responses during the same duration, a university research here has shown.

Our preprint on waning immunity at 16 weeks after a single dose, in the elderly individuals. Neutralising antibodies and antibodies for variants wane in the elderly but memory responses intact. However, even after a single dose, those younger than 60 had very good responses.

ALSO READ: Covid-19 lockdown negatively impacted women's nutrition in India: Study

93 per cent had antibodies at 16 weeks, after a single dose, Professor Neelika Malavige of the Department of Immunology and Molecular Sciences of the Sri Jayawardenepura University here has said in a tweet.

"Our paper on the first dose responses of Covishield vaccine is published in @NatureComms. 93.4% individuals developed antibodies to a single dose of the vaccine and 97.1% developed neutralising antibodies...Read more.

[insurgentepress]

Exploran nuevas posibilidades de planetas habitables en TRAPPIST 1

Un artículo publicado en @NatureComms revela que la pérdida de atmósferas primarias ricas en H2 de planetas templados como TRAPPIST-1e generalmente deja atmósferas secundarias y condiciones superficiales habitables.

Agencias, Ciudad de México.- Una secuencia de eventos durante la evolución de ciertos planetas rocosos que orbitan estrellas enanas rojas, más frías que el Sol, crea una atmósfera que sería estable a lo largo del tiempo. Un nuevo estudio dirigido por la Universidad de Washington, publicado en Nature Communications, modeló un planeta rocoso orbitando una estrella de este tipo –como los del…

[mariebenz]

Gene That Promotes Inflammation in Asthma Identified

MedicalResearch.com Interview with: Dr. Zasłona and Dr. ONeill Zbigniew Zasłona PhD Luke A. J. O’Neill PhD Professor (Chair of Biochemistry) School of Biochemistry and Immunology Trinity Biomedical Sciences Institute Trinity College Dublin, Dublin, Ireland  MedicalResearch.com: What is the background for this study? Response: Asthma is the most common disease in childhood and the most common respiratory condition in Ireland. It is a disease of environmental and genetic components. It is important to point out that although Ireland has very good air quality, asthma prevalence is very high (the second highest in Europe), and although asthma is not a single gene disease (such as cystic fibrosis) it is very important to study genetic variations in Irish population. Therefore in this study we put emphasis on the genetic component of asthma, rather than environmental factors, especially given that asthma heritability has been estimated as high as 60%. Prevention of asthma by reducing exposure to common risk factors, such as air pollution, will not stop the asthma epidemic in Ireland, as inferior air quality is not an issue. MedicalResearch.com: What are the main findings? Response: Caspase-11 is an innate immunity gene involved in bacterial recognition and LPS/danger signaling. Caspase-11 is a gene coding for a cysteine protease, which is a driver of pyroptosis – a highly inflammatory type of cell death. We have found a novel role for  caspase-11. In our study we show that caspase-11 can provoke a damaging inflammatory reaction in the lungs irritated with allergen and is likely to be a key driver of allergic inflammation in the lungs of asthmatics. MedicalResearch.com: What should readers take away from your report? Response: Caspase-4 (homologue of murine caspase-11) expression is induced in human asthmatics. Our work provides convincing evidence to explore the idea of tackling inflammatory cell death in asthma and presents opportunity to explore inhibition of caspase-4 activity as a novel treatment for asthma. There is a strong genetic component of asthma and we believe that caspase-4 gene polymorphism, resulting in overreactive phenotype, may predispose certain patients to uncontrolled inflammatory cell death, which leads to disease. MedicalResearch.com: What recommendations do you have for future research as a result of this work?  Response: Development of a specific Caspase-4 inhibitor would be of a great value. Testing it in asthma animal models and then in humans would be a next step. We feel it is worth to look for polymorphisms in regulatory sites of Caspase-4 among asthmatic patients. Moreover since caspase-4/11 has not yet been studied beyond bacterial infections, any new context of caspase-4/11 activity would be very informative from the scientific and therapeutic perspective. Citation: Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill. Caspase-11 promotes allergic airway inflammation. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-14945-2 The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.   Read the full article

[sangklp]

RT @paoloactis: Exactly on the day @MukhilRave leaves us to join @BehrendsLab her fantastic work on DNA origami for nanopore biosensing is published @NatureComms https://t.co/yPJnO9TyLm https://t.co/lYXqLQ3bOo https://www.youtube.com/c/lifesang

[2plan22]

The latest Plan22Archibrarians Librarians/Architects Daily! https://t.co/rPceqseHl2 Thanks to @NatureComms @librareon #electionswithht #loksabhaelections2019 2PLAN22 http://twitter.com/2PLAN22/status/1110883069995728896

The latest Plan22Archibrarians Librarians/Architects Daily! https://t.co/rPceqseHl2 Thanks to @NatureComms @librareon #electionswithht #loksabhaelections2019

— Plan22 Archibrarians (@2PLAN22) March 27, 2019

[babyawacs]

When you are within an energy realm that transmit energy charge imbalances, this is how the world would looklike. It all leads to how is energy transmitted subatomically+what IS energy subatomically @iterwomen @natureelectron @naturephysics @naturecomms @

When you are within an energy realm that transmit energy charge imbalances, this is how the world would looklike. It all leads to how is energy transmitted subatomically+what IS energy subatomically @iterwomen @natureelectron @naturephysics @naturecomms @

When you are within an energy realm that transmit energy charge imbalances, this is how the world would looklike. It all leads to how is energy transmitted subatomically+what IS energy subatomically @iterwomen @natureelectron @naturephysics @naturecomms @sciam @arirang @japan @losalamosnatlab @energy well its not the doublehelix sketch from 1953 but itis a vortex-ed quarkcharge imbalance blobout…

[greywolfgraphics]

http://twitter.com/KateRaworth/status/1286216376571625472

'Scientists' Warning on Affluence'. This is a powerful new analysis in @NatureComms by leading ecological economists. For anyone enthralled by the promise of 'green growth': sit down, take a deep breath, and read. Two key diagrams, & abstract in thread. https://t.co/vuO8alJVvy pic.twitter.com/nmPwpEmgbY

— Kate Raworth (@KateRaworth) July 23, 2020

from http://twitter.com/KateRaworth via IFTTT

[insurgentepress]

Desvelan las causas del calentamiento anormal en Groenlandia

Perturbaciones en el balance de energía de la superficie explican que Groenlandia se caliente a un ritmo incluso más rápido que el resto del mundo, así lo reveló una investigación publicada en @NatureComms.

Agencias/Ciudad de México.- Perturbaciones en el balance de energía de la superficie explican que Groenlandia se caliente a un ritmo incluso más rápido que el resto del mundo, con un derretimiento acelerado de la capa de hielo. Es la conclusión de un nuevo estudio, que ha encontrado cómo la radiación de onda larga descendente desde la atmósfera hacia el cielo despejado y la retroalimentación del…

[liliannorman]

Fraud, breach of right of privacy and libel by Nature Communications @NatureComms

Elisa de Ranieri, editor-in-chief, Nature Communications, David Gevaux, chief “physical-sciences” editor, Fiona Gillespie, managing editor, Jasper Franke, associate editor, “Earth team”, Alexander Michael Petersen, asst. professor, engineering, Emmanuel M. Vincent, “climate communications”, Anthony LeRoy Westerling 15 August 2019 Mesdames, gentlemen, Fraud, breach of right of privacy and libel by Nature Communications My attention has been drawn to a purported “peer-reviewed” “research”… Fraud, breach of right of privacy and libel by Nature Communications @NatureComms published first on https://triviaqaweb.tumblr.com/

[sangklp]

'Single-Molecule 3D Image of DNA Origami Bennett Linkage by..' published in @NatureComms. Find it at https://t.co/sndtC6bph2 https://t.co/es7VJHF7yd https://www.youtube.com/c/lifesang

[rossradev]

RT IBMResearch "In NatureComms IBM Q & NIST utilize an interferometric Josephson isolator to protect a superconducting qubit. An optimized version of this isolation scheme could eliminate bulky magnetic isolators, which are detrimental in scalable ar… https://t.co/8HqOHdLMll"

RT IBMResearch "In NatureComms IBM Q & NIST utilize an interferometric Josephson isolator to protect a superconducting qubit. An optimized version of this isolation scheme could eliminate bulky magnetic isolators, which are detrimental in scalable ar… pic.twitter.com/8HqOHdLMll"

— Ross Radev (@Ross_Radev) July 24, 2019

from Twitter https://twitter.com/Ross_Radev