#Mounjaro

[amaditalks]

Every year all of the big diet companies have to come up with some brand new labeling for their plans in order to encourage people to get on the January weight loss train.

This year, Weight Watchers is going further than they’ve ever gone before, by announcing that they have created a new system to give their members access to prescriptions for drugs like Ozempic and Mounjaro.

Let me remind you that these drugs only work while you’re taking them. As soon as you stop, all of your appetite comes back. Your desire to eat returns, and because it has been artificially suppressed it may feel much stronger and less controllable than it was before you took the drugs. Many people who come off these drugs, usually because of cost (because insurers are balking at coverage for weight loss) or shortages (because so many people are taking them for weight loss, which is leaving the diabetics who need them up shit creek) or side effects report that the first weeks are really difficult, mentally painful and often binging occurs.

Additionally, all of these drugs carry a real risk of creating a terribly painful and potentially deadly condition called Gastroparesis, in which your gastrointestinal system just stops functioning, you cannot digest and process food at all.

You do not need to lose weight to be healthy. You do not need to lose weight to be beautiful or attractive, to have success, or love. You do not need to lose weight in order to pursue fitness. If you have particular health needs or goals that can only be achieved by changing the way you eat, (e.g. lowering cholesterol or blood glucose or addressing gastro issues) that does not mean that you need a weight loss diet plan, just one designed toward your needs.

But more than anything, you do not ever need to put another penny into the coffers of the multibillion dollar weight loss industry, which, if it actually had a way to take a fat person and make them thin permanently (something that cannot even be achieved by surgeries that drastically rearrange digestive systems) would be a multi quadrillion dollar industry instead. 

[macgyvermedical]

can you talk a little about wegovy and muonjaro for weight loss?

The answer is maybe.

If it were just the drugs themselves, I'd say absolutely. But there is a surprising amount of cultural baggage associated with these medications, and I don't really know that I can do them justice.

So first, let's talk about weight. There's a fantastic book called "Fat Talk" by Virginia Sole-Smith, about being overweight or obese in an age that prioritizes thinness, and how diet culture in particular is a threat to young people. Another, called "Intuitive Eating" by Elyse Resch, discusses how calorie restriction- commonly cited as the "way" to lose weight along with exercise- only works once or twice, because our bodies get wise to it and want to hold onto fat.

Humans evolved to gain weight. Fat is how we store energy for times when we might not have enough to eat. And if "not having enough to eat" (whether because of famine or because of calorie restrictive dieting) happens repeatedly, we have evolved to change hormones and metabolism so we a) don't need as much food to stay alive and b) are primed to eat more food than we need when it is available.

Aren't human bodies cool?

In the medical world, there are a lot of things tied to weight. For example, statistically, being overweight or obese means you're more likely to have health conditions like high blood pressure, diabetes, and heart disease. It is unclear, though, if those problems are caused by the weight itself, or other dietary, activity, and behavior patterns that may also happen to contribute to the weight gain. Things like a sedentary lifestyle, frequent consumption of foods with low nutritional value, avoidance of medical care due to stigma, or even chronic calorie restrictive dieting.

Unfortunately, due to this statistical tie, there is a lot of effort made in the medical world to get patients to "lose weight at any cost" instead of recommending dietary, activity, and behavior changes for health reasons alone.

Culturally as well, we prioritize thinness as attractiveness. I remember in high school there was a poster in my health classroom that read "Ideal weight- or it might be hard to get a date!". There are lots of negative associations with people who carry more weight, including that they are lazy or stupid- things that have nothing to do with body size.

Now, that doesn't mean that there aren't things that could be benefits of losing weight. For example, joint and back pain can be improved with weight loss. But weight loss is probably not the end-all be-all cure-all it's touted to be.

Because it is really hard for most people to meet this standard of "lose weight at any cost", there has long been medications that purportedly help people lose weight. Most of these medications have been stimulants, which decrease appetite and make it more comfortable to engage in calorie restrictive dieting. They also increase energy, which can make it easier to exercise or tolerate more exercise than would otherwise be possible.

Before we talk about the drugs, I want to say- there are risks and benefits to all medications, including these! The discussion you should always have is what risks are you and your healthcare provider willing to tolerate for the potential positive outcome. Also, this is a discussion of the drugs when used for weight control. The same drugs used for diabetes are at different dosages and have potentially different risk/benefit comparisons.

Ozempic/Wegovy (semaglutide) and Mounjaro/Zepbound (tirzepatide) are both a type of medication called a GLP-1 agonist. GLP-1 agonists are also called incretin mimics, because they mimic a type of hormone (incretin) that tells the brain and body that it is full. This makes it easier to eat a small amount of high nutrition food and feel satisfied. They also work by increasing metabolism. Between the decreased consumption and the increased metabolism, weight is lost.

Over the course of a year and a half, tirzepatide causes about 15-20% average reduction in body weight with continued use. Over the course of about the same time, semaglutide causes an average of about 15% body weight reduction with continuous use. Say, for example, you weigh 100kg. A year and a half on one of these medications could get you down to 85kg.

The problem is, as soon as that drug is withdrawn, the body realizes it was starving, and tries to compensate. These drugs are good at getting rid of weight, but maintaining a new weight usually means staying on a lower dose of the drug perpetually. Most people regain all weight (and potentially more than they lost) within 5 years of stopping the drugs.

Some studies suggest that repeatedly regaining lost weight may be more detrimental to health than remaining overweight or obese when it comes to statistical risk of type 2 diabetes, heart disease, and other "weight-associated" illnesses.

The main side effects are GI-related. Most of these are nausea, vomiting, diarrhea, gas/bloating, constipation, dizziness, and abdominal pain. More severe side effects include pancreatitis (inflammation of the pancreas) and gasteroparesis (paralysis of the stomach and part of the digestive tract).

[shiverandqueeef]

had an appointment with the rheumatologist today and she asked me again if i would consider ozempic. i would like to commit several murders please

[aweightyissue]

On Weight Loss and Morality

Conversations around weight and weight loss have always been contentious.

The oft repeated mantra of weight loss has been “there is no silver bullet.”

It’s a jeering remark meant to chide dieters for trying anything beyond eating skinless chicken breast and 20 hours a week working out.

If you want to lose weight you have to pay the penance for every excess pound. You have to earn it.

Their smug satisfaction of watching weight loss aids fail is salt in the wound. They snickered at limitations and failure of Amphetamines, PhenFen, Ephedrine, Orlistat, LapBands, and Gastric Bypass.

See? You can’t cheat your way out. You did this to yourself, now you must suffer the consequences.

An anti weight loss movement emerged in opposition to this mentality. Body positivity is a healthy response to diet culture; making the radical assertion that existing in your body, the way it is, without trying to change, is not only okay, it’s a good thing.

Love your body and focus on being healthy. Your weight is not your worth. This cannot be said enough. Your worth in this world is not related to how your body looks.

When around came GLP-1 medications, the reactions have been fascinating.

The drugs themselves are remarkably effective, and instead of targeting the weight, they correct the underlying metabolic problem. They’ve been on the market for years and are generally known to be safe.

The ire toward them, is in some ways unsurprising.

No! You can’t do it the easy way! You have to work at it!

You’re stealing them from the deserving- the diabetics. Ironically, the same people they blame for their own illness.

The body positivity crowd response is fascinating as well. Taking the drugs is a betrayal. You shouldn’t want to change your body. You’re giving into diet culture. You shouldn’t want to fit conventional beauty standards.

The response has been negative from both sides. People feel entitled to police the bodies and choices you make about your body.

Both of these reactions are moral judgments. You have to pay for your sins. Either for gluttony or vanity.

The thing is, there should be no judgement at all.

Weight loss requires a lot of mental energy. You have to commit your mental and physical energy to it. There are a million reasons why someone can’t or doesn’t want to do that. And that’s okay. There is no reason why you should feel obligated to.

However, ignoring the very real disabling effects of obesity is also a kind of denial of humanity. It’s not anyone’s business, and to condemn someone for trying to prevent or correct the effects is kind of cruelty all its own.

There’s no reason someone should have to justify their desire to change their bodies or their efforts to do so.

Try to love your body, regardless of its size, but it’s okay if you want to lose weight and you don’t have to justify your reasons or your decision to use medication to do it.

Everyone else, support people if they choose to change their bodies as well as when they choose not to. It’s not your decision, your business or your place to judge them.

We, the body positivity advocates don’t criticize trans people for changing their bodies because they’re unhappy with the way it looks. We don’t shame people with disfiguring congenital defects who choose to have corrective surgery; even when it poses no health risk. We understand the very real effects of social stigma, and wouldn’t criticize them for avoiding it.

You’re punishing people trying to lose weight for the sins of vanity and envy.

The other assholes, you wouldn’t tell a cancer patient “there’s no silver bullet” or snicker when an experimental or risky treatment fails. You don’t tell people with high blood pressure or high cholesterol that taking medicine is “taking the easy way out.” You know it’s cruel, you simply want to punish people for the sins of gluttony and sloth.

All I’m saying is - leave the people taking weight loss meds alone.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

[amassofhumanity]

I had a doctor’s appointment yesterday. The headline is

I’ve lost 83 pounds in a year! Yea me. Yea Mounjaro!

The rest is comparably boring compared to the weight loss. Getting referred to a specialist for cognitive memory testing. My memory has been getting steadily worse. I’ve wondered about the cause: is it medication, old age, or Covid related. Short term and long term have both been sucking out loud.

The doctor was happy about most everything else. Blood pressure could be lower. It’s lower than it was last year (probably due to the weight loss).

Later today I have my first appointment with a mental health therapist. Finding a new therapist can be draining. The new patient paperwork was all online and very extensive. Here’s hoping it goes well.

Thanks for listening.

[ivimhealth01]

How to order

Your Name.................

Your Country/ City ....................

Name of product....................

Quantity needed.................

Address...........

Number/Email

If you happen not to know what dosage to start on.

Tell me

1: What is your target weight?

2: What is your current weight?

3: How much weight you want to lose?

4: How old are you?

[compo67]

Been extremely sick with mounjaro side effects today. I was supposed to write Christmas cards for patrons and friends today. Instead, I laid in bed begging for the sweet release of death.

[the-kestrels-feather]

I hope all of the people using Ozempic and Mounjaro to lose weight without a perscription and the celebrities having fucking "Ozempic and Mounjaro Parties" are enjoying it because I (a person who actually needs it for diabetes management and has a perscription) am about to miss my 3rd week of shots because I've called 3 pharmiacies and not a single one has it.

[150lbs-less]

An introduction~

Hi friends 👋🏻 I’m starting up this page to diary, journal and connect with fellow weight loss baddies.

A little about me…

I’m 27 years old, female, 5’6”, 303 lbs, BMI of 48

Longtime PCOS

Recently diagnosed with high cholesterol

Borderline prediabetic

I’m about to begin my journey with metformin, a calorie deficit & a dream. Hoping to be at my goal weight of 150 within 2 years, and have my life back.

Welcome. I’m so glad you’re here 🫂

[vlolets]

5mg mounjaro so far: i couldn't be less hungry

[thenapturalone]

Took my first dose of mounjaro this morning (before y’all jump down my fucking gullet, I am a Type 2 Diabetic). The doctor said it slows digestion which will act as an appetite suppressant. I did not expect the shit to work so fast tho.

I went out to eat with my wife and baby and ordered a wrap, a bowl of soup, a spankanopita, and a diet soda.

I had a cup and a half of the soda, the spankanopita, and half the wrap. Well, almost half the wrap. I took one bite too many and it almost all came back up. I was not expecting it to work so quickly. I’m taking all of the rest of it home.

The doctor told me that exact thing would happen. She said in the beginning I would take one bite too many and would instantly know my limit. Shit, imma have to start eating slower, drinking less or no liquid while eating, and ordering less.

God damn sugar betes smh. But I am glad I only have to stick myself once a week now instead of four times a day so I ain’t complaining 👌🏾

[mynextchapter25]

22/01/25

Mood: Low/Depressed

2024 wasn't a good year for me. I lost my Grandad, became my Nana's full time carer while also working a full time job and my depression decided it was the perfect time to get worse.

Because of this, I am now on sick leave for 4 weeks which is the first time since I was 18 (almost a decade ago) that I haven't been working. It was meant to give me time to rest and recover but all I'm doing it sleeping late and ignoring the world.

But, I have decided that I will not let 2025 be the year of depression, it is time to actually sort my shit out once and for all!

Starting with:

Ordered Mounjaro to help with weight loss (currently at the heaviest I have ever been... 18st 7lbs).

Getting back into reading to clear my head and stop doom scrolling.

Create and stick to a study plan so I can pass level one CIMA.

Get back to the gym and swimming.

I will make 2025 my year - I will not let my mental health be the reason I don't live my life.

[kiralosesit]

Zepbound Month 2 Recap

[itschellyanne]

7 months & 50lb down.

[amassofhumanity]

Woo-Hoo!

I've lost 99 pounds in a year and a half!! Go me.

That's the highlight from today's doctor visit. The rest is inconsequential.

[ivimhealth01]

Patients taking Wegovy lost an average of 35 lbs (15.9 kg), or about 15% of their body weight compared to 6 lbs (2.7 kg), or roughly 2.5% body weight in the placebo group. Overall, after 68 weeks, 83% of adults taking Wegovy lost 5% or more of their weight compared to 31% of adults taking a placebo