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Methyl Meth Acrylate (MMA) Prices: Trends and Market Dynamics
Methyl Methacrylate (MMA) is a critical chemical compound widely used in the production of acrylic sheets, coatings, adhesives, and other high-performance materials. The price of MMA is a significant determinant of cost structures in industries such as automotive, construction, and electronics. This article explores the recent trends, factors influencing MMA prices, and the market outlook.
Recent Trends in MMA Prices
In 2023 and 2024, MMA prices have exhibited notable fluctuations due to global economic conditions and changes in supply and demand dynamics. During the early months of 2023, MMA prices were relatively stable, with moderate growth driven by steady demand from the construction and automotive sectors. However, the latter half of the year saw increased price volatility as a result of raw material shortages and geopolitical tensions.
One significant trend was the impact of rising crude oil prices on MMA production costs. MMA is derived from acetone cyanohydrin or isobutylene, both of which are petrochemical derivatives. Increases in crude oil prices tend to ripple through the supply chain, raising production costs for MMA. Additionally, disruptions in the global supply chain, particularly in Asia, which is a significant producer of MMA, contributed to pricing challenges.
Get Real time Prices for Methyl Methacrylate (MMA): https://www.chemanalyst.com/Pricing-data/methyl-methacrylate-1288
Key Factors Influencing MMA Prices
Raw Material Costs The price of raw materials such as acetone and methanol directly affects MMA production costs. Fluctuations in these inputs, often linked to crude oil price trends, are a primary driver of MMA prices.
Supply and Demand Imbalance The MMA market is sensitive to shifts in supply and demand. Increased demand from the automotive sector for lightweight materials and the construction industry for durable coatings has supported price increases. On the other hand, oversupply or weak demand due to economic slowdowns can lead to price declines.
Geopolitical Factors Trade restrictions, tariffs, and geopolitical tensions have disrupted the MMA supply chain. For instance, production halts in key exporting countries have tightened global supply, exerting upward pressure on prices.
Environmental Regulations Stricter environmental regulations have increased compliance costs for MMA producers. Companies are investing in sustainable production methods, which could marginally raise costs and prices over the long term.
Market Outlook for MMA Prices
The outlook for MMA prices in the near term is mixed, influenced by economic uncertainties and evolving market conditions. As the global economy recovers, demand from end-use industries is expected to strengthen, supporting price stability or modest growth.
The Asia-Pacific region, particularly China and India, will likely remain pivotal in shaping MMA price trends due to their significant production and consumption capacities. However, macroeconomic factors such as interest rate hikes, currency fluctuations, and potential recessions in key markets may temper price growth.
Sustainability will also play an increasingly important role in the MMA market. Producers adopting bio-based feedstocks and energy-efficient processes may gain a competitive edge, potentially affecting pricing dynamics.
Conclusion
Methyl Methacrylate prices are influenced by a complex interplay of factors, including raw material costs, demand-supply balance, and external economic conditions. While challenges such as supply chain disruptions and regulatory pressures persist, the long-term outlook remains positive, supported by growing demand from diverse industrial applications. Stakeholders must closely monitor market trends to navigate the volatile MMA pricing landscape effectively.
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#Methyl Methacrylate News#Methyl Methacrylate Price Monitor#Methyl Methacrylate Database#Methyl Methacrylate Price Chart
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Global Top 13 Companies Accounted for 82% of total Poly Methyl Methacrylate (PMMA) market (QYResearch, 2021)
Polymethyl Methacrylate (PMMA) is a thermoplastic polymer of Methyl Methacrylate (MMA). It is a clear, strong and lightweight plastic generally used as a substitute to glass due to its energy efficiency and weather resistance.
According to the new market research report “Global Poly Methyl Methacrylate (PMMA) Market Report 2023-2029”, published by QYResearch, the global Poly Methyl Methacrylate (PMMA) market size is projected to reach USD 6.08 billion by 2029, at a CAGR of 7.4% during the forecast period.
Figure. Global Poly Methyl Methacrylate (PMMA) Market Size (US$ Million), 2018-2029
Figure. Global Poly Methyl Methacrylate (PMMA) Top 13 Players Ranking and Market Share (Ranking is based on the revenue of 2022, continually updated)
The global key manufacturers of Poly Methyl Methacrylate (PMMA) include Röhm, Trinseo, Mitsubishi Chemical, Sumitomo Chemical, LX MMA, Lotte MCC, Chi Mei, Double Elephant Optical Material, Wanhua Chemical, Kuraray, etc. In 2021, the global top 10 players had a share approximately 82.0% in terms of revenue.
About QYResearch
QYResearch founded in California, USA in 2007.It is a leading global market research and consulting company. With over 16 years’ experience and professional research team in various cities over the world QY Research focuses on management consulting, database and seminar services, IPO consulting, industry chain research and customized research to help our clients in providing non-linear revenue model and make them successful. We are globally recognized for our expansive portfolio of services, good corporate citizenship, and our strong commitment to sustainability. Up to now, we have cooperated with more than 60,000 clients across five continents. Let’s work closely with you and build a bold and better future.
QYResearch is a world-renowned large-scale consulting company. The industry covers various high-tech industry chain market segments, spanning the semiconductor industry chain (semiconductor equipment and parts, semiconductor materials, ICs, Foundry, packaging and testing, discrete devices, sensors, optoelectronic devices), photovoltaic industry chain (equipment, cells, modules, auxiliary material brackets, inverters, power station terminals), new energy automobile industry chain (batteries and materials, auto parts, batteries, motors, electronic control, automotive semiconductors, etc.), communication industry chain (communication system equipment, terminal equipment, electronic components, RF front-end, optical modules, 4G/5G/6G, broadband, IoT, digital economy, AI), advanced materials industry Chain (metal materials, polymer materials, ceramic materials, nano materials, etc.), machinery manufacturing industry chain (CNC machine tools, construction machinery, electrical machinery, 3C automation, industrial robots, lasers, industrial control, drones), food, beverages and pharmaceuticals, medical equipment, agriculture, etc.
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Global Itaconic acid Market Study Report 2014-2030
Analysis of the ITACONIC ACID MARKET
A comprehensive market study on the ITACONIC ACID MARKET Market provides an overview of the demand-supply and consumption patterns of Itaconic acid Market across six different regions. This market study describes the Itaconic acid Market Market, with focus on major countries and their subsequent demand for different segments. This report on the global Itaconic acid Market market offers a complete overview of various factors impacting positively or negatively on the overall growth of the Keyword market.
Distinct market estimations and forecasts are presented in this comprehensive Itaconic acid Market market study. Various secondary sources such as encyclopedia, directories, technical handbooks, company annual reports, industry association publications, magazine articles, world economic outlook, and databases have been referred to identify and collect information useful for this extensive commercial study of Itaconic acid Market. Moreover, both micro-economic and macro-economic factors have been considered to arrive at growth rate and size estimation in the short and long-term forecast. Prismane Consulting supplements this with primary research. The primary sources are experts from related industries and suppliers. For market forecast, and production / plant operating rates, we assume numerous reasons that drive production including new production capacity is brought on-stream, Planned, and unplanned outages of existing capacities and Subdued demand from end-use applications.
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The current COVID-19 pandemic is causing high and rising human costs worldwide. Isolation, nationwide lockdowns, and widespread closures to stop the spread of the virus have severely impacted the economy. As a result, the global economy declined by an around of -3.5% in 2020, much worse and below the 2008-2009 subprime mortgage crisis. The global economy has grown between 5% and 6% in 2021 and 2022 due to the normalization brought in the regional economic activities on back of the fading COVID-19 pandemic and stability in the crude oil prices. The economic activities have been aided by the new policies surrounding financial, agricultural, industrial, and manufacturing sector. The report on Itaconic acid Market Market studies and outlines the impact of COVID-19 and presents the forecasts for the short, mid and long-term. The report also covers Macro-economic factors like GDP, Population and World Economic integration, Economic & Energy Outlook, Industry & Policy Developments, End-use Industry / Applications Market, Reasoning & Analysis, Insightful Commentary, Market Review, Comparative Analysis, Latest Trends and market developments, Key players, Strategic Issues and Recommendations, Business Opportunity Assessment and much more.
Global Itaconic Acid Demand Analysis By Derivatives,
By Applications, (Volume, Value) (2014–2030)
Strategic Issues
Demand Analysis and Forecast (2014 – 2030)
Demand
Demand Growth Rate (%)
Driving Force Analysis
Global Itaconic Acid Market, By Derivative
Methyl Methacrylate (MMA)
Polyitaconic acid
Styrene Butadiene Itaconic Acid
Global Itaconic Acid Market, By Application
Synthetic Latex
SBR Latex
Unsaturated Polyester Resins
Detergents
Superabsorbent Polymers (SAP)
Others
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Real-world industry, consulting, and market research experience
Average work experience of 10+ years
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Prismane Consulting is a unique global boutique consulting firm with an Indian origin. We present ourselves to the world outside providing management, economic and technical expertise to improve customer engagement, boost operational efficiency, reduce costs, and achieve superior business results. Prismane Consulting serves leading businesses in the field of Chemicals, Petrochemicals, Polymers, Materials, Environment and Energy. We have been advising clients on their key strategic issues solving their toughest and most critical business problems. To know more write to us on [email protected]
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Methyl Methacrylate (MMA)
Methyl Methacrylate (MMA)
Methyl methacrylate, whose chemical formula is C5H8O2 and chemical formula quantity is 100.12, is an organic compound, also known as MMA, or methyl ester for short. HS code for MMA is 2916140010. It is an important chemical raw material and the production of transparent plastic polymethyl methacrylate (PMMA) monomer. It is flammable with a strong pungent smell and is moderately toxic. Long-term exposure should be avoided.
Features of Methyl methacrylate (MMA)
MMA is a colorless volatile liquid and has strong spicy, flammable. Solubility: soluble in ethanol, ethyl ether, acetone, and other organic solvents, slightly soluble in ethylene glycol and water. Flammable, stable, easy to polymerize in the presence of light, heat, ionizing radiation, and catalysts. It can explode when mixed with air. It is flammable when exposed to open fire, high temperature, and oxidant. Combustion stimulates smoke, chemical reaction with oxidants, acids, not long storage, to prevent polymerization.
Specification of Methyl methacrylate (MMA)
Methyl Methacrylate Cas No.
80-62-6
Density
0.944 g/cm3
Formula
C5H8O2
IUPAC NAME
MMA/methyl ester
Boiling Point
100 ℃
Melting Point
-48 ℃
Storage and Delivery of MMA
For the package, MMA is available in drum and iso tank. The drum contains 190kg, and the container load for 20FCL is 15.2tons. The iso tank contains 22MT.
FAQs of Methyl Methacrylate (MMA)
Q.
Is methyl methacrylate toxic?
A.
The acute toxicity of methyl methacrylate is low, but repeated inhalation can still cause irritation to the nasal cavity. Higher concentrations of methyl methacrylate can also affect the kidneys and liver.
Q.
Is methyl methacrylate safe in cosmetics?
A.
It is considered safe and rated as a low-hazard ingredient by the cosmetic database.
https://www.douwin-chem.com/products/methyl-methacrylate-mma/
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Methyl Methacrylate Market Size, Share, Growth Opportunity and Trends by Growing CAGR Till 2026
The global Methyl Methacrylate Market report offers a comprehensive assessment of the market for the forecast years. The report contains several segments and an analysis of the market trends and growth factors that are playing a vital role in the market. These factors encompass the drivers, restraints, and opportunities. This globe industry offers an outlook on the strategic development of the market in terms of revenue profits over the forecast period 2021-2026.
The key market players for the global Methyl Methacrylate market are listed below:
Mitsubishi Rayon
Kuraray
Sumitomo Chemical
Evonik
Arkema
Dow
BASF
Asahi Kasei
LG MMA
Mitsubishi Gas Chemical
Formosa Plastics
Shandong Hongxu
Jilin Petrochemical
Longxin Chemical
Others
Click here to get a FREE Sample Copy of the Methyl Methacrylate Market Research Report @ https://www.decisiondatabases.com/contact/download-sample-12535
The Global Methyl Methacrylate Market Report is equipped with market data from 2016 to 2026. The report gives a market overview covering key drivers and risk factors. The report is bifurcated by top global manufactures mentioning sales, revenue, and prices as applicable. It also evaluates the competitive scenario of the leading players. The report expands to cover regional market data along with type and application. The report forecasts sales and revenue from 2021 to 2026. The detailed sales channel is also covered in the study.
COVID-19 Impact Analysis on Methyl Methacrylate Market
The global pandemic COVID-19 has affected the Methyl Methacrylate market directly or indirectly. This study covers a separate section giving an explicitly clear understanding of the aftereffects of this pandemic. The detailed study highlights the probable outcomes of this global crisis on the Methyl Methacrylate industry. The impact study on production, supply-demand, and sales provides a holistic approach to the future.
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Why Purchase this Report?
A robust research methodology has been followed to collect data for the report. Data, thus collected passes through multiple quality checks to ensure the best quality is served.
The report gives a holistic view of the competitive scenario of the Methyl Methacrylate market
The latest product launches along with technological changes and development are covered in the report.
The data analysis in the report helps in understanding the anticipated Methyl Methacrylate market dynamics from 2021 to 2026.
DecisionDatabases has a vast repository of data, therefore, we can accommodate customized requirements also.
The graphs, tables and pie charts, and info-graphics covered in the report will help in a better understanding of the report.
The market drivers, restraints, upcoming opportunities, and anticipated restraints cited in the report will assist in making an informed decision.
To better understand the market scenario, the Methyl Methacrylate market is segmented as below:
By Types:
ACH Method
Isobutylene Method
Ethylene Method
By Applications:
Polymethyl Methacrylate
Plastic Additive
Surface Coating
Others
By Regions:
North America (U.S., Canada, Mexico)
Europe (U.K., France, Germany, Spain, Italy, Central & Eastern Europe, CIS)
Asia Pacific (China, Japan, South Korea, ASEAN, India, Rest of Asia Pacific)
Latin America (Brazil, Rest of L.A.)
The Middle East and Africa (Turkey, GCC, Rest of Middle East)
The content of the study subjects includes a total of 14 chapters:
Chapter 1: To describe Methyl Methacrylate product scope, market overview, market opportunities, market driving force, and market risks. Chapter 2: To profile the top manufacturers of Methyl Methacrylate, with price, sales, revenue, and global market share of Methyl Methacrylate in 2018 and 2019. Chapter 3: The Methyl Methacrylate competitive situation, sales, revenue, and global market share of top manufacturers are analyzed emphatically by landscape contrast. Chapter 4: The Methyl Methacrylate breakdown data are shown at the regional level, to show the sales, revenue, and growth by region, from 2015 to 2020. Chapter 5 and 6: To segment the sales by type and application, with sales market share and growth rate by type, application, from 2015 to 2020. Chapter 7, 8, 9, 10 & 11: To break the sales data at the country level, with sales, revenue, and market share for key countries in the world, from 2016 to 2021 and Methyl Methacrylate market forecast, by regions, type, and application, with sales and revenue, from 2021 to 2026. Chapter 12, 13 & 14: To describe Methyl Methacrylate sales channel, distributors, customers, research findings and conclusion, appendix, and data source.
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#Methyl Methacrylate Market#Methyl Methacrylate Market Report#Methyl Methacrylate Market Share#Methyl Methacrylate Market Growth#Global Methyl Methacrylate Industry Report#Methyl Methacrylate Market Analysis#Coronavirus Outbreak on Methyl Methacrylate Market#COVID-19 Outbreak on Methyl Methacrylate Market#Methyl Methacrylate Market Demand
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Methyl Methacrylate(MMA) Market 2021-2028 | Comprehensive Study Covid19 Impact Analysis | GET FLAT 20% OFF ON THIS REPORT
GET FLAT 20% OFF ON THIS REPORT
Methyl Methacrylate(MMA) Market Report Coverage: Key Growth Factors & Challenges, Segmentation & Regional Outlook, Top Industry Trends & Opportunities, Competition Analysis, COVID-19 Impact Analysis & Projected Recovery, and Market Sizing & Forecast 2021-2028.
Market Insights
The global Methyl Methacrylate(MMA) market report provides comprehensive product analysis which includes its expected performance, pricing factors, and potential developments during the forecast period 2021-2028. The report confers information about the market’s overall performance, challenges, threats, and opportunities that reflects the present and future market scenario.Along with this, it lays out details on the latest government regulations and norms that impact the growth of the market.A new informative report on the Methyl Methacrylate(MMA) Market was recently published by Ordient Market Research and added to its extensive database for creating better strategic business decisions. It uses various proven research methods like primary and secondary research methods to gather data from various sources. It includes an in-depth analysis of the worldwide segments and sub-segments of the market that contributes to understanding the present status of the Methyl Methacrylate(MMA) market.
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The Global Methyl Methacrylate(MMA) Market Report offers extensive knowledge and information about the Methyl Methacrylate(MMA) market pertaining to market size, market share, growth influencing factors, opportunities, and current and emerging trends. The report is formulated with the updated and latest information of the global Methyl Methacrylate(MMA) market further validated and verified by the industry experts and professionals. The Global Methyl Methacrylate(MMA) Market report contains historical, current, and forecast estimation of the revenue generation and profits for each segment and sub-segment of the Methyl Methacrylate(MMA) market in each key region of the world. The report additionally sheds light on the emerging growth opportunities in the business sphere that are anticipated to bolster the growth of the market.
Market Analysis
The Methyl Methacrylate(MMA) market research report offers in-depth research and analysis of the key aspects of the Methyl Methacrylate(MMA) industry. The report offers holistic marketing research that permits companies to form decisions supported by changing market trends. It includes a market overview that gives a basic understanding of the market. This market is split into different segments, e.g., B. Type, applications, end-users, and sales channels. Additionally, the report includes a competitive analysis and a corporation profile of the key market players.
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Segmentation Outlook
The report gives an extensive analysis of various segments of the market by studying the product range, applications, major regions, and leading companies in the industry. Additionally, the report also dedicates an individual section to give a detailed analysis of the manufacturing process, which includes information collected through both primary and secondary sources of data collection. The primary source of data collection contains interviews of industry experts who offer accurate insights into the future market scenario.
Product Type Coverage (Market Size & Forecast, Major Company of Product Type etc.):
ACH Process
C4 Direct Oxidation
MAN Process
C4 DOE Process
New ACH Process
C2 BASF Process
Application Coverage (Market Size & Forecast, Different Demand Market by Region, Main Consumer Profile etc.):
Acrylic sheet
Moulding/ extrusion compounds
Surface coating
Other
Regions covered in Methyl Methacrylate(MMA) market report are:
North America
United States
Canada
Europe
Germany
France
U.K.
Italy
Russia
Nordic
Rest of Europe
Asia-Pacific
China
Japan
South Korea
Southeast Asia
India
Australia
Rest of Asia-Pacific
Latin America
Mexico
Brazil
Middle East & Africa
Turkey
Saudi Arabia
UAE
Rest of Middle East & Africa
Years Considered to Estimate the Market Size:
History Year: 2015-2020
Base Year: 2020
Estimated Year: 2021
Forecast Year: 2021-2028
Detailed TOC of Methyl Methacrylate(MMA) Market Report 2021-2028:
Chapter 1: Methyl Methacrylate(MMA) Market Overview
Chapter 2: Economic Impact on Industry
Chapter 3: Market Competition by Manufacturers
Chapter 4: Production, Revenue (Value) by Region
Chapter 5: Supply (Production), Consumption, Export, Import by Regions
Chapter 6: Production, Revenue (Value), Price Trend by Type
Chapter 7: Market Analysis by Application
Chapter 8: Manufacturing Cost Analysis
Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers
Chapter 10: Marketing Strategy Analysis, Distributors/Traders
Chapter 11: Market Effect Factors Analysis
Chapter 12: Methyl Methacrylate(MMA) Market Forecast
Continued……
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Global Methyl Methacrylate(MMA) Market Report provide in-depth information about the Leading Competitors involved in this report:
Mitsubishi Rayon
Evonik
Sumitomo Chemical
LG MMA
Asahi Kasei
Arkema
Kuraray
Mitsubishi Gas Chemical
BASF
Dow
Formosa Plastics
Jilin Petrochemical
Longxin Chemical
Shandong Hongxu
What market dynamics does this report cover?
The report shares key insights on:
Current market size
Market forecast
Market opportunities
Key drivers and restraints
Regulatory scenario
Industry trend
New product approvals/launch
Promotion and marketing initiatives
Pricing analysis
Competitive landscape
Study Objectives of Methyl Methacrylate(MMA)
1.The purpose of the market study is to include evidence, estimates, statistics, historical data, and market data verified by the industry, as well as the appropriate methodology and evaluation for a full market assessment.
2.The market research also helps to understand structure by evaluating the dynamics of the market segments.
3.Market segmentation is split based on content, form, end-user, and region; the global market size of Methyl Methacrylate(MMA) is expected.
4.The major points considered in the Global Methyl Methacrylate(MMA) Market report include the leading competitors operating in the global market.
5.The report also contains the company profiles of the players operating in the global market.
6.The manufacture, production, sales, future strategies, and the technological capabilities of the leading manufacturers are also included in the report.
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Ordient Market Research is the most extensive dataset of the intact market-related survey. Being tech-driven market researchers, we progressively analyze large datasets. This helps us to gain in-depth insight and offer comprehensive consulting. Ordient Market Research specializes in detailed market analysis and research reports. Let it be profit-making, commercial, or industrial; we serve almost all sectors of online business. We understand the importance of market statistical surveying.
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Juniper Publishers-Open Access Journal of Head Neck & Spine Surgery
Percutaneous Vertebroplasty as a Treatment for Osteoporotic Vertebral Compression Fractures
Authored by Alimov Ijod
Abstract
Percutaneous vertebroplasty is a minimally invasive procedure for the treatment of osteoporotic and neoplastic vertebral compression fractures; this procedure involves the injection of bone cement directly into the fractured vertebral body. The purpose of this study was to evaluate the efficacy of percutaneous vertebroplasty for patients with painful osteoporotic vertebral compression fractures. This was a retrospective single-center study; the total number 74 percutaneous vertebroplasty was performed in 41 patients with osteoporotic vertebral body compression fractures of the I and II degrees. Of these 41patients, 5 were male (12%) and 36(88%) were female; the average age of the patients was 66 years (range, 55-78 years). The overall procedure time was 51.2 ± 4.2 (range, 34-55)min. The average cement volume injected into vertebra was 4.5 ± 0.54 (range, 3.4-6.0)ml. The mean follow-up was 16.0 ± 4.2 (range, 12-24) months. All patients achieved substantial pain relief after surgery; the Visual Analogue Scale (VAS) score decreased significantly from a pre-operative value of 8.4 ± 1.2 to a post-operative value of 2.0 ± 0.2 and was maintained at 2.2 ± 0.4 at the final follow-up (p < 0.01). Our study confirmed that percutaneous vertebroplasty is effective treatment modality for osteoporotic vertebral compression fractures, which offers short and long-term statistically significant benefits in decreasing pain and increasing mobility.
Keywords: Osteoporotic vertebral compression fractures; Percutaneous vertebroplasty
Introduction
Osteoporotic vertebral compression fractures (OVCFs) are the most common single osteoporotic fractures worldwide, constituting an integral part of the osteoporotic syndrome; they occur in 30-50% of people over the age of 50 [1]. The OVCFs have a negative impact on health related quality of life and are associated with increased mortality. Conservative management, including bed rest, pain relievers, bracing and physical therapy, may fail to relieve pain and frequently lead to prolonged immobilization, depression and a substantial negative impact on life quality. Percutaneous vertebroplasty (PVP) is a minimally invasive procedure for the treatment of OVCFs; it consists of percutaneous injection of biomaterial, such as Polymethyl methacrylate (PMMA), into the fractured vertebral body [2]. The procedure is well tolerated even under local anesthesia. Biomechanical testing has shown that PVP can restore strength and stiffness of the vertebral body to the pre-fracture levels. The advantages of PVP included are following: reduction in pain, disability, and analgesic use; as well as stabilization of the vertebral fracture [3]. The short-term risk factors of PVP are associated with a cement leakage into the spinal canal or into the venous system; the long-term risk factor of PVP is incidence of new vertebral fracture. The PVP as a treatment mode for painful vertebral compression fractures provided long-term therapeutic effects in 70-95% of the patients [4]. Cost-effective analysis revealed that PVP is most cost-effective treatment procedure in patients with OVCFs in Japan [5]. Thus, the aim of our study was to evaluate the immediate post-interventional and long-term outcomes after PVP in terms of pain relief.
Material and Methods
Data were collected retrospectively from the records of patients treated between 2015 and 2017 at the department of “Traumatology, orthopedics, neurosurgery with military surgery“ of the Tashkent Medical Academy (TMA). The study was executed in compliance with the Helsinki Declaration and local data protection regulations of TMA. The database included data from patients who signed an informed consent form allowing the use of their clinical data for research purposes. Indications for PVP were the presence of single or multiple vertebral compression fractures of vertebral bodies of the I and II degree with a strong pain syndrome, along with osteoporosis, which was preoperatively diagnosed by dual-energy X-ray absorptiometry (DXA). Patients undergoing vertebroplasty for other conditions such as vertebral metastasis, multiple myeloma or traumatic fractures of the spine were excluded. Contraindications of PVP were following: osteomyelitis, discitisor active systemic infection; unstable spinal fracture, patients with diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis; severe uncorrectable coagulopathy; impaired cardiopulmonary function; neurologic deficits and spinal cord compression syndrome; bone fragment retropulsion; allergy to bone cement or opacification agents. The following examinations were made in all the patients prior PVP: detailed clinical evaluation, including a the neurological status; blood test with extended coagulogram; imagining modalities such as such X-ray, magnetic resonance tomography (MRT) or multislice computed tomography (MSCT). Osteoporosis was preoperatively diagnosed by dual X-ray absorptiometry in all patients. In order to evaluate the severity of the pain, the visual analog scale (VAS) was used; this system grades pain based on the following: 0=absence of pain, 2 = mild pain, 4=moderate pain, 6=severe pain, 8=extreme pain 10=worst pain. The cemented proportion of the vertebral body was determined using volumetric analysis of the postoperative CT scan of the treated levels.
Statistical analysis was performed using SPSS for Windows version 18.0 (SPSS Inc., Chicago, IL, USA). All variables were analysed using descriptive statistical methods. Data are presented as the mean and standard deviation for continuous variables and as percentages for categorical variables. Comparisons of pain outcomes pre- and postoperatively were made using a paired t test. Differences were considered statistically significant when p < 0.05.
Procedure
The preoperative prophylactic antibiotic cefazolin 1g, was administered intravenously. The procedure was performed under local anesthesia. The transpedicular approach was used to access the collapsed vertebral body in the thoracic and lumbar spine. The vertebral venography has been used for the identification of potential routes of cement venous leakage. The cement is composed of methyl methacrylate and monomer liquid, which were mixed together. Cement injection was done under continuous lateral fluoroscopic control; it was injected using a 13-gauge cannula. The fractured vertebral body was gradually filled with cement until admissible endpoints. Cement injection was interrupted in case of venous leakage into the veins or spinal canal. Patients were in supine position within 1.5hour after the procedure, the assessment of vital functions and neurological status were examined in every 15 minutes. The control MSCT or CT of the treated level was performed in the first 2-3 days after the procedure.
Results
A total of 41 patients (36 females and 5 males) met the inclusion criteria and were treated with PVP and then included in the follow-up program that is still going on. The total number 74 percutaneous vertebroplasty was performed in 41 patients with traumatic compression fractures of vertebral bodies of the I and II degree. Of these 41, 5 participants were male (12%) and 36(88 %) were female; the average age of the patients was 66 years (range, 55-78 years). The average operative time was 51.2 ±4.2 (range, 34-55)min. The average cement volume was 4.5 ± 0.54 (range, 3.4-6.0)ml. The mean follow-up was 16.0 ± 4.2 (range, 12-24) months. The evaluation of the results of treatment was carried out according to the following criteria: dynamics and severity of pain syndrome prior and after percutaneous vertebroplasty, motor activity of the patient, and dependence on analgesics. All patients achieved substantial pain relief after surgery. The VAS score decreased significantly from a preoperative value of 8.4 ± 1.2 to a post-operative value of 2.0 ± 0.2 and was maintained at 2.2 ± 0.4 at the final follow-up (p < 0.01). The extravasation of cement into the venous plexuses was noted in 1 patient, which was the reason of occlusion of small branches of the pulmonary arteries, and clinical presentations of this case was asymptomatic. No other complications were encountered. All patients were able to sustain rapid mobilization within 12- 24h after procedure, and the mean hospitalization length after PVP was 3.5 days (range 3-5). The long- term results revealed that all patients had significantly improved mobility, and by the end of the first postoperative month and mainstay during following 24 month, there were not any subsequent vertebral fractures. In additionally, during the follow up period the majority of patients reported that decreased usage pain relief medicines or not used (Figure 1 & 2).
Discussion
To date, there are several vertebral augmentation modalities are applied to reduce pain and stabilize compression fractures of the spine; over the decade, the PVP and balloon kyphoplasty (BKP) are used and the novel procedures are radiofrequency kyphoplasty and percutaneous implant techniques [6]. The advantage of PVP/PKP in comparison to conservative management or open surgery has been well established in terms of decreasing pain and improving QOL of patients with OVCFs [7]. Nevertheless, the complications of PVP / PKP are associated with the risk of cement leakage during procedures. The spinal extravasation can lead to cord and nerve injury as well as paravertebral soft tissue and intervertebral disc damage; the venous extravasation into the epidural and vertebral veins can cause cardiac and pulmonary cement embolization. In our series, the incidence of embolism of the pulmonary arteries was 2.34% (1/41), which was significantly lower then recently reported in literature for PVP/PKP, which was ranged between 3.5% and 23% [8]. Therefore, the early postoperative clinical and radiological (CT or MSCT) examinations are recommended to check the proper implants position, but also to detect the possible cement migration.
The controversy exists as to whether PVP/PKP can increase the risk for new OVCFs during follow-up .The experimental biomechanical studies demonstrated that PVP/PKP increased stiffness and strength. Besides, the augmented vertebrae after PVP/PKP increased loading in adjacent vertebrae, inducing subsequent fractures. To resolve the issues, to date the some modifications of injected cements are being developed in experimental studies. Schroder et al. [9], conducted experimental study to examine the influence of adding 10 and 30vol% isotonic saline on the biomechanical properties of PMMA vertebroplasty cement. The result of this study demonstrated that compressive stiffness of PMMA-based vertebroplasty cement could be reduced to almost a third by the addition of saline. The probable explanation is an increase in microporosity of cement, which can reduce the risk of subsequent vertebral fractures [9]. Another investigation by Liu et al. [10] tested newly designed CPB cement for replacing the PMMA in PVP and PKP. The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo. The results of this investigation demonstrated that the biological performance of CPB outperformed the non-degradable PMMA. The authors concluded that CPB has revolutionary potential to replace the PMMA in the applications such as PVP and PKP [10]. Certainly, the above-mentioned two experimental studies are required further evaluation in clinical settings.
Conclusion
Our study demonstrated that PVP offers statistically significant short and long- term benefits in decreasing pain and increasing mobility for patients with OVCFs. The perioperative complication of cement leakage observed only in one patient, there were not any subsequent vertebral fractures in long- term follow-up.
For more articles in Open access Journal of Head Neck & Spine Surgery | Juniper Publishers please click on: https://juniperpublishers.com/jhnss/index.php
#Head and neck surgery#Osteoporotic Vertebral#compression fractures#Percutaneous vertebroplasty#Neurosurgery#osteoporosis
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Methyl Meth Acrylate (MMA) Price | Prices | Pricing | News | Database | Chart
Methyl Methacrylate (MMA) is a vital chemical compound used in various industrial applications, primarily as a precursor to polymethyl methacrylate (PMMA), a transparent thermoplastic widely employed in products like acrylic glass and various coatings. The prices of MMA are influenced by several dynamic factors, making it crucial for businesses and consumers to stay informed about market trends and fluctuations. Over recent years, the MMA market has experienced notable price volatility, driven by factors such as feedstock availability, production capacity, and global economic conditions.
The pricing of MMA is significantly influenced by its primary raw materials, which include acetone and propylene. Changes in the cost of these feedstocks directly impact MMA production expenses, leading to price fluctuations in the MMA market. For instance, if there is a surge in the price of propylene due to supply chain disruptions or geopolitical tensions affecting oil production, the cost of MMA is likely to rise correspondingly. Similarly, any increase in acetone prices can result in higher production costs for MMA manufacturers. Hence, monitoring the pricing trends of these essential raw materials is crucial for understanding MMA market dynamics.
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Another essential factor affecting MMA prices is the overall production capacity within the industry. MMA is produced through several methods, including the process of esterification of methacrylic acid with methanol or through the oxidative esterification of isobutylene. The efficiency and output of these production processes can vary among manufacturers. For instance, if a major producer experiences unplanned downtime due to maintenance or equipment failure, this can lead to a temporary reduction in MMA supply, driving prices higher. Conversely, if new production facilities are brought online or existing plants expand their capacity, increased supply can lead to lower prices in the MMA market.
Moreover, demand-side factors play a critical role in determining MMA prices. Industries such as automotive, construction, and electronics significantly drive the demand for MMA-based products. The growth of these sectors can lead to increased consumption of MMA, placing upward pressure on prices. For example, the rising demand for lightweight and durable materials in the automotive industry has contributed to the growing use of PMMA and, consequently, MMA. Additionally, any fluctuations in the economic climate can impact consumer spending and industrial output, further influencing demand for MMA.
Seasonal variations can also affect MMA pricing. For instance, the construction industry tends to see increased activity during warmer months, leading to higher demand for MMA in coatings, adhesives, and other applications. During these peak seasons, prices may rise due to heightened demand. Conversely, during off-peak seasons, the market may experience a downturn, resulting in lower prices as demand wanes. Hence, understanding seasonal trends is essential for businesses engaged in the MMA market.
Geopolitical events and global trade dynamics also contribute to the complexity of MMA pricing. Trade disputes, tariffs, and changes in import/export regulations can significantly impact the availability and cost of MMA in different regions. For example, if a major producing country faces trade restrictions, this can lead to supply shortages in other markets, causing prices to spike. Similarly, fluctuations in currency exchange rates can affect the competitive positioning of MMA producers in the global market. Thus, businesses must stay vigilant and adapt their strategies in response to these external factors.
In recent years, environmental concerns and regulations have started to play an increasingly important role in the MMA industry. As governments worldwide implement stricter environmental regulations, manufacturers are pressured to adopt more sustainable practices. This shift can lead to increased production costs, as companies invest in greener technologies and processes to comply with regulations. These costs may ultimately be passed on to consumers in the form of higher MMA prices. Additionally, the demand for bio-based alternatives to traditional MMA may arise, leading to changes in market dynamics and price structures.
Market speculation is another factor that can contribute to MMA price fluctuations. Traders and investors closely monitor supply and demand trends, economic indicators, and geopolitical events to make informed decisions. Speculation can lead to short-term price volatility, as market participants react to perceived future changes in supply and demand. This behavior can create additional challenges for businesses that rely on stable pricing for their MMA procurement strategies.
In conclusion, the prices of Methyl Methacrylate are shaped by a myriad of factors, including raw material costs, production capacity, demand trends, seasonal variations, geopolitical dynamics, environmental regulations, and market speculation. As the MMA market continues to evolve, staying informed about these factors is essential for businesses, consumers, and stakeholders. By closely monitoring market trends and adjusting their strategies accordingly, industry participants can navigate the complexities of the MMA market and make informed decisions. Understanding these intricate dynamics will enable businesses to optimize their operations and maintain a competitive edge in a constantly changing landscape.
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Global Top 9 Companies Accounted for 62% of total Heat Resistant Polymethyl Methacrylate market (QYResearch, 2021)
Polymethyl Methacrylate (PMMA) is a thermoplastic polymer of Methyl Methacrylate (MMA). It is a clear, strong and lightweight plastic generally used as a substitute to glass due to its energy efficiency and weather resistance. Heat resistant grade is a special grade of PMMA for excellent resistance to high temperature and to surface scratching. Outstanding transparency and weatherability are equivalent to general PMMA. This material is applied to parts that require high thermal stability such as high intensity lamps. The disadvantages of general-purpose grade PMMA are insufficient surface hardness, poor heat resistance, and low impact strength. The heat-resistant grade PMMA can withstand temperatures in excess of 110 degrees Celsius.
According to the new market research report “Global Heat Resistant Polymethyl Methacrylate Market Report 2023-2029”, published by QYResearch, the global Heat Resistant Polymethyl Methacrylate market size is projected to reach USD 0.71 billion by 2029, at a CAGR of 9.8% during the forecast period.
Figure. Global Heat Resistant Polymethyl Methacrylate Market Size (US$ Million), 2018-2029
Figure. Global Heat Resistant Polymethyl Methacrylate Top 9 Players Ranking and Market Share (Ranking is based on the revenue of 2022, continually updated)
The global key manufacturers of Heat Resistant Polymethyl Methacrylate include Röhm, Trinseo, Mitsubishi Chemical, Chi Mei, LX MMA, etc. In 2021, the global top four players had a share approximately 62.0% in terms of revenue.
About QYResearch
QYResearch founded in California, USA in 2007.It is a leading global market research and consulting company. With over 16 years’ experience and professional research team in various cities over the world QY Research focuses on management consulting, database and seminar services, IPO consulting, industry chain research and customized research to help our clients in providing non-linear revenue model and make them successful. We are globally recognized for our expansive portfolio of services, good corporate citizenship, and our strong commitment to sustainability. Up to now, we have cooperated with more than 60,000 clients across five continents. Let’s work closely with you and build a bold and better future.
QYResearch is a world-renowned large-scale consulting company. The industry covers various high-tech industry chain market segments, spanning the semiconductor industry chain (semiconductor equipment and parts, semiconductor materials, ICs, Foundry, packaging and testing, discrete devices, sensors, optoelectronic devices), photovoltaic industry chain (equipment, cells, modules, auxiliary material brackets, inverters, power station terminals), new energy automobile industry chain (batteries and materials, auto parts, batteries, motors, electronic control, automotive semiconductors, etc.), communication industry chain (communication system equipment, terminal equipment, electronic components, RF front-end, optical modules, 4G/5G/6G, broadband, IoT, digital economy, AI), advanced materials industry Chain (metal materials, polymer materials, ceramic materials, nano materials, etc.), machinery manufacturing industry chain (CNC machine tools, construction machinery, electrical machinery, 3C automation, industrial robots, lasers, industrial control, drones), food, beverages and pharmaceuticals, medical equipment, agriculture, etc.
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Acetone Market 2020 Outlook, Current and Future Industry Landscape Analysis
INTRODUCTION:
Acetone is also a potent solvent, and in the field of chemistry is also widely known as propanone. The acetone formula is (CH3)2CO or C3H6O. It belongs to the functional group Ketone (RC(=O)R '), making it the smallest and simplest ketone. Acetone's common household uses are as the active ingredient in the nail polish remover described in the above and as a thinner.
The molar mass of Acetone has a value of 58gm/mol. It is a colorless liquid which is miscible in benzene, ethanol, etc. Acetone is an organic compound that is water-miscible. Acetone was first developed by distillation of Lead(II) acetate (Pb(CH3COO)2) by Andreas Libavius in the year 1606.
Acetone naturally occurs in plants and trees in the world. It is a substance that evaporates very quickly from volcanic gases, even from water and soil. Due to microbial consumption, acetone can pose a significant risk of oxygen depletion in aquatic systems. Acetone is widely used as a solvent to make plastics, synthetic fabrics and in other industrial products other than nail polish remover. In the textile industry, acetone is commonly used for wool degreasing and silk degumming.
INFORMATION FOR MATERIAL HANDLING IN THE ACETONE MARKET
Acetone has a high flammability. On burning, acetone glows with yellow flames. Vapors may flow to distant ignition sources along surfaces and flash back. The Auto-ignition temperature is also dependent on the time of exposure, it is quoted as 525 °C in some studies. A small volume of water that also prevents ignition is also likely to produce industrial acetone. Acetone is slightly toxic in nature. The properties associated with this substances makes it useful as a solvent in industries.
Acetone is produced directly or indirectly from propylene. Roughly 83% of acetone is delivered through the cumene cycle, therefore, acetone production is attached to phenol creation. In the cumene cycle, benzene is alkylated with propylene to create cumene, which is oxidized via air to deliver phenol and acetone.
PRODUCTION OF ACETONE:
In 2010, the overall production limit with respect to acetone was expected to be 6.7 million tons for each year. With 1.56 million tons for every year, the United States had the most noteworthy production capacity, followed by Taiwan and mainland China.
The Acetone Market attained a marginal growth rate in the year 2019. The product obtained a Compound annual growth rate (CAGR) of 9% during the forecast period (2021-2026). Worldwide Acetone utilization is separated into two solvents, Bisphenol A (BPA) and Methyl Methacrylate.
Besides, organizations occupied with the downstream usage of acetone items like BPA and MMA are looking at to extend their business by a few mergers and obtaining. The economic downturn has currently slowed down the growth of the acetone market.
Global Market Database can be used to analyse the shift in line with changing market trends and the overall dynamics associated with the existing GMD markets. The forecast and scenario based analysis for mature industrial markets can be studying using this market research tool. The B2B market research platform studies and analyses the changing market dynamics of the overall chemical sector.
ACETONE MARKET COMPETITIVE MAPPING FOR REGION
Acetone creation is significantly concentrated in China, USA, Taiwan, South Korea and western European region. Asia Pacific witnessed a staggering development for Acetone in 2019. The market is foreseen to contribute to maximum share in the forecast period. The growth is attributable to quickly extending pharmaceutical and electronics sectors. Additionally, option of Phenol/Acetone limits in China lately will bring about diminished reliance of import and make it self-dependable.
Production of acetone, across Europe has indicated a slow decrease because of a fall sought after influencing the synthetic imports. North America positions as the second-biggest regional segment primarily driven by its application in solvent manufacturing. Canada is the fastest developing nation which has market with rising interest for solvents. Then again, rising consumer spending on technology in the U.S. has prompted rising interest for buyer gadgets, impelling the interest for Bisphenol A.The counties which are more prone to develop the market rate of acetone are as follows – U.S., Canada, Germany, France, Belgium, CIS China, India, Japan, South Korea, Taiwan, Brazil and Mexico.
INDIAN ACETONE MARKET
The India acetone market is anticipated to exceed USD 147 million by 2025, owing to the rising demand from different end-use industries, such as construction and electronics coupled with increasing chemical imports. Furthermore, India is also expected to ramp up its domestic production in the coming years as it has imposed anti-dumping duties on Acetone imports from South Korea, Saudi Arabia and China.
In monetary year 2019, the production volume of acetone across India was around 41 thousand metric tons. The Indian chemical industry is exceptionally differentiated. With a coverage of more than 80 thousand items, the south Asian nation was the 6th biggest producer of synthetics on the planet and the fourth biggest in Asia. The plant named as Deepak Phenolics Limited, will be able to produce 120,000 tons/year of acetone making it the largest acetone plant of India. The mapping for the Indian market with respect to the Global perspective can be studied using Global Market Database. The cloud based market research platform which provides dynamic market data. Free Market research data can be obtained for the first five GMD logins. The site can be useful for secondary research purposes.
CONCLUSION
The size of the acetone market is most likely to see huge increases from 2019 to 2025, due to the rise in demand for plastics across the globe. The global acetone portion of the overall industry is heavily divided. In 2015, the worldwide use of acetone was estimated at approximately 6.1 million tons, hitting a market value of USD 7.3 trillion by the end of the estimated duration (2016-2026). The demand for acetone has seen an expansion in production worldwide. The demand for acetone was less affected by the recent capacity expansion in Asia compared with phenol. In the last five years, global acetone industry demand has experienced an average growth of 3 percent.
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Research On World 2-Hydroxyethyl Methacrylate Market Report 2025
Report on World 2-Hydroxyethyl Methacrylate Market by Product Type, Market, Players and Regions-Forecast to 2025 offered by DecisionDatabases.com.
2-Hydroxyethyl Methacrylate market research report provides the newest industry data and industry future trends, allowing you to identify the products and end users driving Revenue growth and profitability.
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Final Report will cover the impact of COVID-19 on this industry.
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The Players mentioned in our report
Mitsubishi Rayon
Evonik
Geo
Nippon Shokubai
MGC
Sanlian Chem
Anhui Renxin
Zibo Xinglu Chemical
Hickory
Dow
Anshun Chem
Fangda Chem
Hechuang Chem
Sanmu Group
Global 2-Hydroxyethyl Methacrylate Market: Product Segment Analysis
93%≤Purity<97%
97%≤Purity<99%
99%≤Purity
Global 2-Hydroxyethyl Methacrylate Market: Application Segment Analysis
Coatings
Reactive Resins
Adhesives
Global 2-Hydroxyethyl Methacrylate Market: Regional Segment Analysis
USA
Europe
Japan
China
India
South East Asia
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Other Reports by DecisionDatabases.com:
World Methyl Methacrylate (MMA) Market Research Report 2025
World HEMA (Hydroxyethyl Methacrylate) Market by Product Type, Market, Players and Regions-Forecast to 2025
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Multi-surface Structural Adhesives Market Growth Advancement, Improvement to 2025
Global Multi-surface Structural Adhesives Market Research Report 2019 Presents Intellect by Leading Players, Type, Applications, Distribution Channel, Consumption, Revenue (Mn/Bn USD) and Region --Forecast to 2025.
The analysis on the Multi-surface Structural Adhesives Market provides complete data. Components, as an instance, the situation of the small organization enterprise, significant players size, SWOT analysis, and also patterns on the market are within the study. Along with that, the Multi-surface Structural Adhesives report tables, numbers on growth, figures, and graphs offering a view of this market.
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Top Players/Businesses-
HENKEL, ASHLAND, SIKA, ARKEMA, 3M, DOW CHEMICAL COMPANY, LORD CORPORATION, ILLINOIS TOOL WORKS, SCOTT BADER, Multi-surface Structural Adhesives
Market Products and Applications:Product Types:
Epoxy
Polyurethane
Acrylic
Methyl Methacrylate
Multi-surface Structural Adhesives
Applications Types:
Automotive
Aerospace
Marine
Building and Construction
Wind Energy
Multi-surface Structural Adhesives
Geographies Analyzed are:-
North America
Asia-Pacific
UK, Europe
Central & South America
Middle East & Africa
The prime purpose with this global Multi-surface Structural Adhesives market report would help to comprehend industry concerning its definition, segmentation and possibilities, essential trends and also the challenges which the current market is facing. The Multi-surface Structural Adhesives research represents the majority of our efforts, supplemented by a thorough secondary investigation. We analyzed Multi-surface Structural Adhesives report that is relevant, annual reports, media releases and players product to promoting understanding and analysis.
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Percutaneous Vertebroplasty as a Treatment for Osteoporotic Vertebral Compression Fractures-Juniper publishers
Abstract
Percutaneous vertebroplasty is a minimally invasive procedure for the treatment of osteoporotic and neoplastic vertebral compression fractures; this procedure involves the injection of bone cement directly into the fractured vertebral body. The purpose of this study was to evaluate the efficacy of percutaneous vertebroplasty for patients with painful osteoporotic vertebral compression fractures. This was a retrospective single-center study; the total number 74 percutaneous vertebroplasty was performed in 41 patients with osteoporotic vertebral body compression fractures of the I and II degrees. Of these 41patients, 5 were male (12%) and 36(88%) were female; the average age of the patients was 66 years (range, 55-78 years). The overall procedure time was 51.2 ± 4.2 (range, 34-55)min. The average cement volume injected into vertebra was 4.5 ± 0.54 (range, 3.4-6.0)ml. The mean follow-up was 16.0 ± 4.2 (range, 12-24) months. All patients achieved substantial pain relief after surgery; the Visual Analogue Scale (VAS) score decreased significantly from a pre-operative value of 8.4 ± 1.2 to a post-operative value of 2.0 ± 0.2 and was maintained at 2.2 ± 0.4 at the final follow-up (p < 0.01). Our study confirmed that percutaneous vertebroplasty is effective treatment modality for osteoporotic vertebral compression fractures, which offers short and long-term statistically significant benefits in decreasing pain and increasing mobility.
Keywords: Osteoporotic vertebral compression fractures; Percutaneous vertebroplasty
Introduction
Osteoporotic vertebral compression fractures (OVCFs) are the most common single osteoporotic fractures worldwide, constituting an integral part of the osteoporotic syndrome; they occur in 30-50% of people over the age of 50 [1]. The OVCFs have a negative impact on health related quality of life and are associated with increased mortality. Conservative management, including bed rest, pain relievers, bracing and physical therapy, may fail to relieve pain and frequently lead to prolonged immobilization, depression and a substantial negative impact on life quality. Percutaneous vertebroplasty (PVP) is a minimally invasive procedure for the treatment of OVCFs; it consists of percutaneous injection of biomaterial, such as Polymethyl methacrylate (PMMA), into the fractured vertebral body [2]. The procedure is well tolerated even under local anesthesia. Biomechanical testing has shown that PVP can restore strength and stiffness of the vertebral body to the pre-fracture levels. The advantages of PVP included are following: reduction in pain, disability, and analgesic use; as well as stabilization of the vertebral fracture [3]. The short-term risk factors of PVP are associated with a cement leakage into the spinal canal or into the venous system; the long-term risk factor of PVP is incidence of new vertebral fracture. The PVP as a treatment mode for painful vertebral compression fractures provided long-term therapeutic effects in 70-95% of the patients [4]. Cost-effective analysis revealed that PVP is most cost-effective treatment procedure in patients with OVCFs in Japan [5]. Thus, the aim of our study was to evaluate the immediate post-interventional and long-term outcomes after PVP in terms of pain relief.
Material and Methods
Data were collected retrospectively from the records of patients treated between 2015 and 2017 at the department of “Traumatology, orthopedics, neurosurgery with military surgery“ of the Tashkent Medical Academy (TMA). The study was executed in compliance with the Helsinki Declaration and local data protection regulations of TMA. The database included data from patients who signed an informed consent form allowing the use of their clinical data for research purposes. Indications for PVP were the presence of single or multiple vertebral compression fractures of vertebral bodies of the I and II degree with a strong pain syndrome, along with osteoporosis, which was preoperatively diagnosed by dual-energy X-ray absorptiometry (DXA). Patients undergoing vertebroplasty for other conditions such as vertebral metastasis, multiple myeloma or traumatic fractures of the spine were excluded. Contraindications of PVP were following: osteomyelitis, discitisor active systemic infection; unstable spinal fracture, patients with diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis; severe uncorrectable coagulopathy; impaired cardiopulmonary function; neurologic deficits and spinal cord compression syndrome; bone fragment retropulsion; allergy to bone cement or opacification agents. The following examinations were made in all the patients prior PVP: detailed clinical evaluation, including a the neurological status; blood test with extended coagulogram; imagining modalities such as such X-ray, magnetic resonance tomography (MRT) or multislice computed tomography (MSCT). Osteoporosis was preoperatively diagnosed by dual X-ray absorptiometry in all patients. In order to evaluate the severity of the pain, the visual analog scale (VAS) was used; this system grades pain based on the following: 0=absence of pain, 2 = mild pain, 4=moderate pain, 6=severe pain, 8=extreme pain 10=worst pain. The cemented proportion of the vertebral body was determined using volumetric analysis of the postoperative CT scan of the treated levels.
Statistical analysis was performed using SPSS for Windows version 18.0 (SPSS Inc., Chicago, IL, USA). All variables were analysed using descriptive statistical methods. Data are presented as the mean and standard deviation for continuous variables and as percentages for categorical variables. Comparisons of pain outcomes pre- and postoperatively were made using a paired t test. Differences were considered statistically significant when p < 0.05.
Procedure
The preoperative prophylactic antibiotic cefazolin 1g, was administered intravenously. The procedure was performed under local anesthesia. The transpedicular approach was used to access the collapsed vertebral body in the thoracic and lumbar spine. The vertebral venography has been used for the identification of potential routes of cement venous leakage. The cement is composed of methyl methacrylate and monomer liquid, which were mixed together. Cement injection was done under continuous lateral fluoroscopic control; it was injected using a 13-gauge cannula. The fractured vertebral body was gradually filled with cement until admissible endpoints. Cement injection was interrupted in case of venous leakage into the veins or spinal canal. Patients were in supine position within 1.5hour after the procedure, the assessment of vital functions and neurological status were examined in every 15 minutes. The control MSCT or CT of the treated level was performed in the first 2-3 days after the procedure.
Results
A total of 41 patients (36 females and 5 males) met the inclusion criteria and were treated with PVP and then included in the follow-up program that is still going on. The total number 74 percutaneous vertebroplasty was performed in 41 patients with traumatic compression fractures of vertebral bodies of the I and II degree. Of these 41, 5 participants were male (12%) and 36(88 %) were female; the average age of the patients was 66 years (range, 55-78 years). The average operative time was 51.2 ±4.2 (range, 34-55)min. The average cement volume was 4.5 ± 0.54 (range, 3.4-6.0)ml. The mean follow-up was 16.0 ± 4.2 (range, 12-24) months. The evaluation of the results of treatment was carried out according to the following criteria: dynamics and severity of pain syndrome prior and after percutaneous vertebroplasty, motor activity of the patient, and dependence on analgesics. All patients achieved substantial pain relief after surgery. The VAS score decreased significantly from a preoperative value of 8.4 ± 1.2 to a post-operative value of 2.0 ± 0.2 and was maintained at 2.2 ± 0.4 at the final follow-up (p < 0.01). The extravasation of cement into the venous plexuses was noted in 1 patient, which was the reason of occlusion of small branches of the pulmonary arteries, and clinical presentations of this case was asymptomatic. No other complications were encountered. All patients were able to sustain rapid mobilization within 12- 24h after procedure, and the mean hospitalization length after PVP was 3.5 days (range 3-5). The long- term results revealed that all patients had significantly improved mobility, and by the end of the first postoperative month and mainstay during following 24 month, there were not any subsequent vertebral fractures. In additionally, during the follow up period the majority of patients reported that decreased usage pain relief medicines or not used (Figure 1 & 2).
Discussion
To date, there are several vertebral augmentation modalities are applied to reduce pain and stabilize compression fractures of the spine; over the decade, the PVP and balloon kyphoplasty (BKP) are used and the novel procedures are radiofrequency kyphoplasty and percutaneous implant techniques [6]. The advantage of PVP/PKP in comparison to conservative management or open surgery has been well established in terms of decreasing pain and improving QOL of patients with OVCFs [7]. Nevertheless, the complications of PVP / PKP are associated with the risk of cement leakage during procedures. The spinal extravasation can lead to cord and nerve injury as well as paravertebral soft tissue and intervertebral disc damage; the venous extravasation into the epidural and vertebral veins can cause cardiac and pulmonary cement embolization. In our series, the incidence of embolism of the pulmonary arteries was 2.34% (1/41), which was significantly lower then recently reported in literature for PVP/PKP, which was ranged between 3.5% and 23% [8]. Therefore, the early postoperative clinical and radiological (CT or MSCT) examinations are recommended to check the proper implants position, but also to detect the possible cement migration.
The controversy exists as to whether PVP/PKP can increase the risk for new OVCFs during follow-up .The experimental biomechanical studies demonstrated that PVP/PKP increased stiffness and strength. Besides, the augmented vertebrae after PVP/PKP increased loading in adjacent vertebrae, inducing subsequent fractures. To resolve the issues, to date the some modifications of injected cements are being developed in experimental studies. Schroder et al. [9], conducted experimental study to examine the influence of adding 10 and 30vol% isotonic saline on the biomechanical properties of PMMA vertebroplasty cement. The result of this study demonstrated that compressive stiffness of PMMA-based vertebroplasty cement could be reduced to almost a third by the addition of saline. The probable explanation is an increase in microporosity of cement, which can reduce the risk of subsequent vertebral fractures [9]. Another investigation by Liu et al. [10] tested newly designed CPB cement for replacing the PMMA in PVP and PKP. The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo.The results of this investigation demonstrated that the biological performance of CPB outperformed the non-degradable PMMA. The authors concluded that CPB has revolutionary potential to replace the PMMA in the applications such as PVP and PKP [10]. Certainly, the above-mentioned two experimental studies are required further evaluation in clinical settings.
Conclusion
Our study demonstrated that PVP offers statistically significant short and long- term benefits in decreasing pain and increasing mobility for patients with OVCFs. The perioperative complication of cement leakage observed only in one patient, there were not any subsequent vertebral fractures in long- term follow-up.
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Methyl Meth Acrylate (MMA) Prices | Pricing | News | Database | Index | Chart | Forecast
Methyl methacrylate (MMA) prices have been a subject of significant interest and fluctuation in recent years, driven by a confluence of factors ranging from raw material costs and supply chain disruptions to shifting demand patterns and geopolitical influences. Understanding the trends in MMA pricing is crucial for businesses and stakeholders in industries such as automotive, construction, and electronics, where MMA plays a pivotal role in manufacturing processes. One of the primary drivers of MMA prices is the cost of raw materials. MMA production relies heavily on petrochemical feedstocks such as acetone and hydrogen cyanide, both of which are susceptible to price volatility due to fluctuations in crude oil prices. When oil prices soar, the cost of producing MMA typically follows suit, leading to higher prices for end-users. Conversely, when oil prices drop, there is often a corresponding decline in MMA prices, though this relationship can be influenced by other factors such as supply chain efficiencies and production capacity.
Supply chain dynamics also play a critical role in shaping MMA prices. Disruptions caused by natural disasters, geopolitical tensions, or logistical challenges can lead to shortages in raw materials or finished products, driving up prices. For instance, hurricanes or other natural disasters affecting key production regions can lead to temporary shutdowns of manufacturing facilities, creating supply bottlenecks that result in price spikes. Similarly, geopolitical tensions that affect trade routes or international relations can disrupt the smooth flow of materials, contributing to price volatility. The demand for MMA is closely linked to the health of the global economy and the performance of key industries that utilize MMA-based products. In periods of economic growth, demand for MMA tends to rise as construction activities increase, automotive production ramps up, and consumer electronics sales surge. This heightened demand can put upward pressure on prices, especially if supply struggles to keep pace. Conversely, during economic downturns, demand for MMA may wane, leading to potential oversupply and downward pressure on prices. Additionally, the growing emphasis on sustainability and environmental regulations has impacted MMA prices. Regulatory measures aimed at reducing emissions and promoting eco-friendly practices have led to increased production costs for MMA manufacturers, who must invest in cleaner technologies and processes. These costs are often passed on to consumers in the form of higher prices. Moreover, the push for bio-based alternatives to traditional petrochemical-derived MMA has introduced new dynamics into the market, with bio-based MMA sometimes commanding premium prices due to its perceived environmental benefits.
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Technological advancements and innovation within the MMA industry also influence pricing. Companies that invest in cutting-edge production techniques and efficiency improvements can often produce MMA at lower costs, allowing them to offer more competitive pricing. On the other hand, those lagging in technological adoption may face higher production costs, which can translate into higher prices for their products. Another critical factor in MMA pricing is the competitive landscape. The presence of multiple manufacturers and suppliers in the market can lead to competitive pricing strategies, with companies vying for market share through price adjustments. However, market consolidation or the dominance of a few key players can sometimes lead to less competitive pricing environments, with prices being influenced more by the actions of these major players than by broader market forces.
The global nature of the MMA market means that regional factors can also significantly impact prices. For example, in regions where there is robust demand growth, such as in emerging markets in Asia-Pacific, prices may be higher due to the strong local demand coupled with limited regional supply. Conversely, in regions with slower demand growth or excess production capacity, prices may be more subdued. Furthermore, currency fluctuations can affect MMA prices in different regions, as changes in exchange rates can alter the cost dynamics for imported raw materials and finished products. It is also important to consider the role of trade policies and tariffs in shaping MMA prices. Trade restrictions, tariffs, or changes in trade agreements can alter the competitive landscape, impacting the cost of importing or exporting MMA. These factors can lead to price adjustments as companies seek to navigate the changing trade environment.
In conclusion, MMA prices are influenced by a complex interplay of raw material costs, supply chain dynamics, demand fluctuations, regulatory impacts, technological advancements, competitive forces, regional factors, and trade policies. Businesses operating within the MMA market must remain vigilant and adaptable to these changing conditions to effectively manage their costs and pricing strategies. By staying informed about the various factors influencing MMA prices, stakeholders can make more strategic decisions and better navigate the challenges and opportunities within this dynamic market.
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Global Acetone Market Study 2015 - 2030
Analysis of the ACETONE MARKET
A comprehensive market study on the ACETONE MARKET Market provides an overview of the demand-supply and consumption patterns of Acetone Market across six different regions. This market study describes the Acetone Market Market, with focus on major countries and their subsequent demand for different segments. This report on the global Acetone Market market offers a complete overview of various factors impacting positively or negatively on the overall growth of the Keyword market.
Distinct market estimations and forecasts are presented in this comprehensive Acetone Market market study. Various secondary sources such as encyclopedia, directories, technical handbooks, company annual reports, industry association publications, magazine articles, world economic outlook, and databases have been referred to identify and collect information useful for this extensive commercial study of Acetone Market. Moreover, both micro-economic and macro-economic factors have been considered to arrive at growth rate and size estimation in the short and long-term forecast. Prismane Consulting supplements this with primary research. The primary sources are experts from related industries and suppliers. For market forecast, and production / plant operating rates, we assume numerous reasons that drive production including new production capacity is brought on-stream, Planned, and unplanned outages of existing capacities and Subdued demand from end-use applications.
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The current COVID-19 pandemic is causing high and rising human costs worldwide. Isolation, nationwide lockdowns, and widespread closures to stop the spread of the virus have severely impacted the economy. As a result, the global economy declined by an around of -3.5% in 2020, much worse and below the 2008-2009 subprime mortgage crisis. The global economy has grown between 5% and 6% in 2021 and 2022 due to the normalization brought in the regional economic activities on back of the fading COVID-19 pandemic and stability in the crude oil prices. The economic activities have been aided by the new policies surrounding financial, agricultural, industrial, and manufacturing sector. The report on Acetone Market Market studies and outlines the impact of COVID-19 and presents the forecasts for the short, mid and long-term. The report also covers Macro-economic factors like GDP, Population and World Economic integration, Economic & Energy Outlook, Industry & Policy Developments, End-use Industry / Applications Market, Reasoning & Analysis, Insightful Commentary, Market Review, Comparative Analysis, Latest Trends and market developments, Key players, Strategic Issues and Recommendations, Business Opportunity Assessment and much more.
Global Acetone Demand-Supply Analysis, By Application, (Volume, Value) (2015–2030)
Strategic Issues
Demand-Supply Analysis and Forecast (2015 – 2030)
- Capacity
- Capacity Utilization (%)
- Production
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- Demand Growth Rate (%)
- Driving Force Analysis
Global Acetone Market, By Application
- Bisphenol-A (BPA)
- Methyl Methacrylates (MMA)
- Methyl isobutyl ketone (MIBK)
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