#M. Malady Photographs

[mandy-malady]

[alain-keler]

Dimanche 11 avril 2004.

AFP. Je suis accueilli très gentiment par Menachen, un photographe de l’agence que je connais depuis très longtemps.

Contacts, idées.

Couvent arménien dans la vieille ville de Jérusalem, avec Eyal, un photographe israélien. L’endroit est magnifique.

Le mur à Adu Dis. Étrange serpent de béton rompant la beauté de cette magnifique vallée proche de Jérusalem. Il n’est pas achevé. Gigantisme maladie des politiques.

Une inscription en hébreu dit :

« Isn’t there one father to tell us weren’t we created by a single god ? Why should we betray each other (litteralement en hébreu : each one at his brother) to desecrate the agreement ( convenance) between our forefather. Jehuda was betrayed and … was done in Jesus and Israël* ».

from the book of malaki, one of the prophet, chapter 2, versus 10 to 11

D’autres inscriptions « Is there anyone there ?, the wall will come down » –from the wall, Pink Floyd-

Rencontré Rula, une photographe palestinienne connue en 1993.

Téléphoné à Jim Hollander.

Léo au téléphone.

* « N'y a-t-il pas un père pour nous dire que nous n'avons pas été créés par un seul dieu? Pourquoi devrions-nous nous trahir (litteralement en hébreu: chacun chez son frère) pour profaner l'accord (convenance) entre nos ancêtres. Jehuda a été trahi et… a été fait en Jésus et en Israël ».

[melodieyvonne]

Welcome to Melodie Yvonne’s Digital Dreams Gallery where the dream is a wish Melodie’s heart makes ❤ ❤ ❤ Photos by Melodie Yvonne

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[silva16boyd-blog]

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[yourreddancer]

Two fresh looks at the 1918 flu pandemic that rocked the world

Two fresh looks at the 1918 flu pandemic that rocked the world

Karen R. Long  Newsday

A century ago, a virulent, highly contagious flu infected an estimated one-third of the globe. Somewhere between 50 and 100 million people died. The 1918 influenza took more lives in 15 months than AIDS has claimed in 40 years and buried more than the bubonic plague killed in a century.

A submicroscopic virus composed of just eight genes would turn out to be the killer, wiping out “more humans than any other disease in a period of similar duration in the history of the world,” as historian Alfred W. Crosby put it.

Very few witnesses remain among us, but a tower of books - including Crosby's influential 1989 “America's Forgotten Pandemic” - has sought to document the scale of the horror.

British schoolchildren slumped dead at their desks, and German furniture vans hauled bodies scattered in the streets to the cemeteries. Panicked South Africans threw dying miners from trains to expire along the tracks. In days, sometimes in hours, the flu would start with a dull headache or burning eyes, then chills and fever. Almost all the infected would live, but for an unlucky 2.5 percent, the lungs filled with a reddish fluid, the lips and ears turned dusky blue and the victim's feet turned black. The struggle for air produced a hellish cough that mimicked a duck's quack. Doctors couldn't stop it or treat it or even pinpoint its cause.

Jeremy Brown, a London-trained emergency room physician who now directs the NIH Office of Emergency Care Research, turns indignant in his new book, “Influenza: The Hundred-Year Hunt to Cure the Deadliest Disease in History,” at the quackery his field once perpetrated. His first chapter, “Enemas, Bloodletting, and Whiskey,” unpacks the nonsense - and harm - physicians threw at their patients, including killing many of them with aspirin overdoses.

“The flu is still a serial killer,” Brown notes, adding that it “is certainly not 'the emperor of all maladies,' as cancer was described by the oncologist Siddhartha Mukherjee, but it is the malady of all empires. It has been with us since the dawn of time, and it has afflicted each civilization and society in every corner of the globe.”

A second Brit, journalist Catharine Arnold, has timed her own flu retrospective to the centennial. “Pandemic 1918: Eyewitness Accounts from the Greatest Medical Holocaust in Modern History” is not above a lurid subtitle, but its psychologist author picks a better opener for her book.

She begins in an English churchyard 10 years ago, where an Oxford don is exhuming the body of Sir Mark Sykes, a prime-of-his life British diplomatfelled as he helped negotiate the peace in Paris after World War I. Buried in a lead casket, which delaysdecomposition, the corpse was hoped to retain enough soft tissue to enablescientists to extract the virus. (It didn'twork. The lead coffin had cracked.) Grave excavations provide colorful anecdotes in both books. Most led to disappointments, but

one - in Brevig Mission, Alaska - hit pay dirt in 1997 when a 73-year-old Swedish scientist returned to the far-northern permafrost. He found that the extra fat on an obese flu victim preserved enough of the 1918 virus in one of the four samples he culled from her body to help unlock the virus' RNA pedigree.

Brown tells this story with a welcome scientific crispness, but Arnold supplies the telling human details: The Swede names the silent donor “Lucy” in a nod to the famous hominid unearthed in Ethiopia. Both of these books' covers feature the same striking 1918 photograph, a cavernous, crowded emergency ward of stricken soldiers at Camp Funston in central Kansas. This photo also illustrates an excellent 2017 Smithsonian Magazine article on the pandemic from historian John M. Barry.

Readers wanting a briefer foray should find it online. “The Great Influenza,” Barry's 2004 book, is better written than either of the two new volumes. So is “Flu” by science journalist Gina Kolata.

The new works, then, must make fresh information their justification. Here, Brown's book is superior to Arnold's meander through the archives. He depicts the shortfalls of big data in flu tracking, the pitfalls in our annual flu vaccinations and the scandalous medical politics bedeviling Tamiflu and similar treatments.

'Influenza: The Hundred-Year Hunt to Cure the Deadliest Disease in History'

By Dr. Jeremy Brown Touchstone, 272 pages, $26.99

'Pandemic 1918: Eyewitness Accounts from the Greatest Medical Holocaust in Modern History'

By Catharine Arnold St. Martin's Press, 368 pages, $27.99

[jeanharlow1930s]

'Goodnight, my Dearest Darling'  

Jean Harlow was making her last film Saratoga, costarring Clark Gable. One day she was out ill with what they said was a cold. William Powell took the afternoon off work to take care of her, bringing her chicken soup and ice cream. There are different reports of her final days.

"Only three weeks before she was stricken with the malady that was to end her life, she came to the studio carrying a cake with her. She was as pleased as a little girl with it. 

"'This is our third anniversary cake,' she said laughing at the three little candles decorating the top. 'Bill sent it because it was the anniversary of our first date.'" 

-- Louella O. Parsons article, The Milwaukee Sentinel, June 15, 1937 

Later things took a turn for the worse. Violet Denoyer an MGM makeup artist and friend of Jean Harlow's was applying the star's make up for Saratoga. "Suddenly, Miss Denoyer said, Miss Harlow looked at her and said, 'You know, Violet I have a feeling I'm going away from here and never coming back.'

"Two hours later while she was on the set, she turned to Robert Golden a director and gasped, 'I'm terribly sick, Red. Call Bill.' 

"She referred to William Powell, suave film star who had been her constant escort for more than a year. Since Christmas she had worn a huge star sapphire ring on the third finger of her right hand. It was a gift from Powell. He and a studio nurse took her home the day she became ill. Miss Harlow never returned. Powell was with her when she died." 

-- St. Petersburg Times, June 9, 1937 

"This is the last photograph of the beautiful star

and was taken during the final scenes of Saratoga,

an M-G-M film in which she was starred with Clark Gable."

-- 1937 article about the funeral

She was doing Saratoga. We sat in the back of the car. Jean was on my left and she looked very fragile and she had the ring that Bill Powell had given her, it was a big star sapphire. It was on her finger and her hands looked almost too Newspaper accounts of her death talked of Powell's being at her bedside.frail to lift that big ring. 

"And I said, 'Jean you don't look very well.'

"And she said 'I feel awful, just awful,' she said. 'I don't know if I can finish the picture.'" 

-- Maureen O'Sullivan was another big MGM star, a friend of Powell and Harlow. She appeared in The Thin Man to name just one of her many famous films. O'Sullivan is also the mother of actress Mia Farrow. Quote from Harlow Biography.

William Powell went to her home and was one of those instrumental in having her transferred to a hospital.

As said, there is debate as to whether they were engaged or not at the time of her death, there's even debate as to whether or not they were still a couple. Not unusually with a romance like theirs and a big star dies young, different stories began circulating quickly. The press is eager for any news. 

William Powell spoke in a very rare interview about Jean Harlow's death. He seemed moved to respond in 1964-65 by a biography and films that were coming out. Powell said no one thought her illness was that serious. They thought she'd be back at work in a few days. He went to see her on Sunday. From the article....

"She startled me and said, 'You look fuzzy.' 

"'I don't, really?' I joked. But I was suddenly worried. I held up my hand. 'How many fingers can you see?' I asked her. She couldn't see any. This was very disturbing.

"I called the doctor and asked him to come right away. In a matter of minutes he was there. He took one look at her and called for an ambulance.

"Mrs. Bello and I rode with her to The Good Samaritan Hospital where she was put immediately into an oxygen tent.

"We spent the night in the hospital, but Jean was in a coma and didn't know we were there. In the morning, she died." 

The date was June 7, 1937. After almost three decades, Bill's voice broke and it was hard for him to go on. 

His final gift to the girl he loved and admired was a $25,000 crypt at Forest Lawn Memorial Park for Jean and for the mother he adored when her time would come. They are there together in death, very close, as they were in their time on earth. 

-- The Miami News, January 10, 1965 

A fire chief who'd come to the hospital was interviewed. Members of the city fire department inhalator squad called at the last minute to furnish oxygen for the declining star.

Some papers said that her final word was his name, and he had been too choked up to respond. Some articles at the time and years later said that she'd died in his arms. "But it was too late then," Recalls Powell. "She was too far gone. She died in my arms. It was the saddest day of my life."

 -- The Tuscaloosa News, December 13, 1964

Motion Picture Daily Magazine displayed an image

of Jean Harlow's photograph and a grieving MGM lion.

Anything and everything was reported. Her half-hysterical mother urging her to keep fighting. Their friend, actor Warner Baxter paced outside her death chamber in the hall. And the inevitable, "Powell was wearing a sports suit and polo shirt without a necktie."

What killed Jean Harlow? People began having theories immediately. Some wanted to place blame, talk of how it could have been prevented while those closest to her were in still in shock and grieving.  

She died of uremic poisoning, better known as acute renal failure or kidney failure in June 1937, her age was just��26. This was a time before dialysis and kidney transplants.  

Motion Picture Daily ran this note:

"Loew's Spooner in the Bronx and Loew's Astoria, Astoria, L.I. which are showing Personal Property in which Jean Harlow appears will stop the shows for one minute today. The shows will be halted at the time funeral services are to be held in Glendale, Cal." 

Jean Harlow's Funeral:

Guests were limited to 200-250 people. Myrna Loy, Spencer Tracy, Carole Lombard, Warner Baxter, Una Merkel, Maureen O'Sullivan, W.S. Van Dyke, Robert Montgomery were there. 

Clark Gable was a pall bearer. Nelson Eddy sang Ah, Sweet Mystery of Life and Jeannette MacDonald sang The Indian Love Call.  Powell sat beside Jean's mother at the funeral. His own mother sat on his other side. 

Jean Harlow's first and third husbands, Charles McGrew and Hal Rosson, were in attendance.

 "Her second husband was Paul Bern, a film producer whose death a few months after their wedding is still somewhat mysterious, without full explanation of motives for suicide."

-- Gettysburg Times, June 9, 1937 

The service was temporarily interrupted by the drone of aeroplanes overhead." 

Police guards were there to keep the crowds back, though fans got in after the services to take souvenirs such as flower petals. 

"Barred from the funeral service yesterday a crowd waited for hours outside the cemetery hoping at least to see some of the 200 film notables inside. 

"This they missed but after the brief service was finished and everybody was gone, they rushed through unlocked gates and scrambled for bits of the thousands of flowers. 

"Some had to be content with tiny scraps of ferns. One little girl placed in her purse a few petals from a rose."

-- The Tuscaloosa News, June 10, 1937 

Carole Lombard is reported to have said to Clark Gable, "Paw, don't ever let them do this to me." Gable and Lombard would marry in 1939. Tragically, Lombard, who helped Powell through his grieving for Jean Harlow, was killed in a plane crash only five years later in 1942.  

Similarly, in 1958, Gable would tell wife, Kay Williams that he didn't want to have a funeral like the large one given to actor Tyrone Power, who'd died of a heart attack. In November 1960, Clark Gable himself died of a heart attack. The wives of both Power and Gable were pregnant at the times of their husbands' deaths.

Reports of Jean Harlow's funeral said that "the services were simple, brief and unostentatious." Others said that MGM boss, Louis B. Mayer had orchestrated something like a scene in a Hollywood film.  

"As a special tribute, all film studios were observing one minute of silence at 9 o'clock." 

There are photos of an anguished Powell wearing dark glasses. He helped Jean's mother to her car. But other photos show his own mother, Mrs. Nettie Powell and Otis Wiles friend and studio attache on either side of him. Another friend, it's said is behind him just in case. 

Wee Kirk O' the Heather 

in Forest Lawn Memorial Park

The flower blanket made of 500 gardenias and 1500 lilies of the valley that covered the casket were from from Bill's father William Powell, Sr., his mother and Jean Harlow's mother. 

One floral token, however went with the platinum blonde screen star to her resting place. Placed in her hand just before the casket was closed for the last time. It was a single gardenia, her favorite flower, with the inscription, 'Good-night my dearest darling.' The card was unsigned but the handwriting was believed to be that of William Powell, constant escort of Miss Harlow of recent months, who was among the most obviously grief-stricken at the funeral." 

-- The Evening Independent, June 10, 1937 

[collectorscorner]

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[mandy-malady]

[ontaimelaterre]

bah non c’est même pas vrai, des fois ça rend tellement malade 🤕 que tu voudrait mourrir... _________________________________ #fumer #smoke #cigarette #kill #maladie #bpco #tabac #tabacco #wasted #trash #planetearth #pictures #photo #art #nature #environnement #pollution #naturelovers #earth #ecology #ecologie #recycled #recyclage #recycling #recyclingart #naturephotography #photography #photographer #travelphotography (à Picardie, France) https://www.instagram.com/p/BtqSmLToHXW/?utm_source=ig_tumblr_share&igshid=1lbtvc51pnqty

[awesomemartineanciauxthings-blog]

Londres 22-3-2017 Sincères Condoléances à Nos Amis Anglais Et Londoniens, ainsi qu'Aux Familles Ayant perdu un Ëtre Cher,  hier dans ce terrible attentat de Londres, de même nous pensons aux 40 blessès, et à nos 3 lycéens français, ainsi qu'aux personnes traumatisés dont les séquelles auront du mal à s'en remettre, et à tout ces familles directement touchés par ce drame, de la patience et beaucoup de courage Aussi, nous, nous garderons à vie, dans notre mémoire ces attentats meurtriers, commis par des fanatiques  dans tous les pays du monde, et n'oublierons jamais de leurs rendre les hommages, à tous ceux qui ont du subir des préjudices et de la peine Amitiés MARTINE ANCIAUX ET THOMAS André London 22-3-2017 Sincere Condolences to Our Friends English And Londoners, as well as To Those Families Having lost a Being Dear yesterday in this terrible London attack, so we think about the 40 wounded, and our 3 French high school students, as well as the traumatized persons whose The after-effects will be hard to recover, and to all those families directly affected by this drama, patina and a lot of courage We, therefore, will keep in our memory these murderous attacks committed by fanatics in all the countries of the world, and we will never forget to pay homage to those who have suffered prejudice and Sentence With all our Friendship MARTINE ANCIAUX ET THOMAS André 20 août 2015 "I'll Remember You" de Elvis Presley 19-09-2015 Il est des maladies très difficiles à simplement évoquer, l'alzheimer est une de ces maladies dont la perte de vie du malade devient insoutenable à voir, ou à subir, pour autant doit on les abandonner? THOMAS ANDRE, écrivain ,poète, MARTINE ANCIAUX, photographe d’art,créatrice de la photo-peinture, Martine ANCIAUX creator of the photo painting,art photographer, Larousse Alzheimer: Affection neurologique chronique, d'évolution progressive, caractérisée par une altération cérébrale irréversible aboutissant à un état démentiel. La maladie d'Alzheimer se traduit par une dégénérescence nerveuse d'évolution inéluctable, causée par une diminution du nombre de neurones avec atrophie cérébrale et présence de « plaques séniles ». Pour moi Thomas andré J’ai voulu parler d’une maladie qui touche directement nos souvenirs, notre mémoire , la maladie d’Alzheimer, cette maladie qui nous fait peur, et qu’inexorablement devient dans nos vies de plus en plus présentes. Cette peur que nous avons de ne plus nous rappeler de notre vie, et de toutes les séquences que nous avons vécu avant d’arriver au terme de notre vie ©MEMOIRE POEME THOMAS André© Aussi loin, que je me rappelle, Mais déjà, ma mémoire m’interpelle, Moi qui pouvait tout mémoriser, Je me sens prisonnier, de ce cerveau traumatisé.

Des neurones qui s’étiolent, et se meurent, Des souvenirs qui se perdent de plus en plus, Et moi, qui ne comprends plus, Attendant la définition d’une maladie, qui fait peur, et on en meurent.

Alors, dans le peu de vie, qui me reste, J’écume mes beaux jours, en vidéos, et je peste, De ne plus pouvoir en avoir, Car là, malheureusement je n’en ai plus le pouvoir.

Des sentiments de joie, Restent encore en moi, Mais une profonde peine aussi est en moi, Comment moi, l’imbattable des adresses et des noms, de m’en souvenir je n’en ai plus la joie.

Aussi ces images, me consolent, Et mes yeux de larmes se désolent, Ennuyeux de tant souffrir, Et pourtant, que me suis-je pas battu pour ne pas en souffrir.

Jouant au scrabble, et aux jeux de mots, Et maintenant, il est des instants, où il me manque ces mots, Ceux de l’échange, Ceux des conversations, qui se côtoient, et se mélangent.

Alors petit, profite du moment, Vis le intensément, Et n’oublies jamais, Et je te le redit, que ta mémoire vive, te laisse tes souvenirs à jamais. Google translation 19-09-2015 MEMORY © POEME THOMAS ANDRE © As far as I remember, But already, my memory concerns me, I, who could memorize everything, I feel prisoner of the traumatized brain. Neurons that wither, and die, Memories that are lost more and more, And I, who do not understand, Pending the definition of a disease, scary, and we die. So the little life I have left, I spray my heyday, videos, and I rant, Not being able to have, For there, unfortunately I have more power. Feelings of joy, Remain in me, But also deep sorrow in me, How I, the unbeatable addresses and names to remember it I have more joy. Also these images, comfort me, And my eyes with tears grieve, Annoying to suffer so much, And yet, what am I not beaten not suffer. Playing scrabble, and word games, And now there are moments where I lack the words, Those of trade, Those conversations, which coexist and mingle. So little, enjoying the moment, Screw him intensely, And do not forget ever, And I'll repeats, may your memory, leave you your memories forever.

[photograpia]

(45/)100 Books, 2016

I started 2016 with the insane goal to read 100 books in 12 months- foolishly forgetting that I would be returning to medical school mid-year and naturally trading in leisure reads for Robbins, Bates, and Harrison. Still have no regrets about attempting to read more last year however, and can confidently say I came across some of the best books I’ve read in my 25 years on this planet. 

In the photograph above are the top 6 titles I picked up in 2016. Three about medicine, three about food (which should tell you so much about what my year was like). 

Food 

Eating for Beginners by Melanie Rehak

Voracious: A Hungry Eater Cooks her Way through Great Books by Cara Nicoletti 

Tikim: Essays about Philippine Food and Culture by Doreen Gamboa-Fernandez

Medicine

Adventures in Human Being by Gavin Francis, MD

Patient H.M.: A Story of Memory, Madness, and Family Secrets by Luke Dittrich

When Breath Becomes Air by Paul Kalanithi, MD

45/100 Books: 

Above the East China Sea by Sarah Bird 

50 Children: One Ordinary American Couple’s Extraordinary Rescue Mission Into the Heart of Nazi Germany by Steven Pressman 

Some Girls, Some Hats, and Hitler by Trudi Kanter

First they Killed My Father by Loung Ong 

After they Killed My Father by Loung Ong

Lulu in the Sky by Loung Ong

Between Life and Survival by Dr. Beat Richner

Scandalous Sisterhood of Prickwillow Place by Julie Berry

Life in Rewind by Terry Weible Murphy

Emmy and Oliver by Robin Benway

Eating for Beginners by Melanie Rehak

The Promised World by Lisa Tucker

Such Good Girls by RD Rosen 

Second Helpings of Roast Chicken by Simon Hopkinson

The Art of Hearing Heartbeats by Jan-Philipp Sendker

Learning to Listen: A Life Caring for Children by Dr. T Berry Brazelton

Rosemary: The Hidden Kennedy by Kate Clifford Larsen 

Be Frank with Me by Julia Claireborne Johnson

In a Rocket Made of Ice by Gail Gutradt

Adventures in Human Being by Gavin Francis 

When Breath Becomes Air by Paul Kalanithi, MD

The Little Girl who Fought the Great Depression: Shirley Temple and 1930s American by John F. Kasson 

Girl Sleuth: Nancy Drew and the Women Who Created Her by Melanie Rehak

Essays on Philippine Food and Culture by Doreen Gamboa Fernandez

Internal Medicine by Terence Holt, MD

Leaving Deep Water: Asian American Women at the Crossroads of Two Cultures by Claire S. Chow

What Doctors Feel: How Emotions Affect the Practice of Medicine by Danielle Ofri, MD

Anne Frank and the Children of the Holocaust by Carol Ann Lee

The World According to Star Wars by Cass R. Sustein 

Guns, Germs, and Steel by Jared Diamond

Where’d You Go Bernadette by Maria Semple

Between Expectations: Lessons from a Pediatric Residency by Meghan Maclean Weir, MD

The Emperor of All Maladies by Siddhartha Mukherjee, MD

The Road Less Taken, by M Scott Peck, MD

Patient H.M. by Luke Dittrich 

Cured: How the Berlin Patients Defeated HIV and Changed Medical Science by Nathalia Holt

A Lolong Time Ago: A Prehistory of the Philippines by Halo-Halo Histories

Voracious: A Hungry Reader Cooks Her Way Through Great Books by Cara Nicoletti

Fantastic Beasts and Where to Find Them by JK Rowling

Princesses Behaving Badly by Linda Rodriguez McRobbie

Tales of the Peculiar by Ransom Riggs

Sojourns by Christina Pantoja Hidalgo

This Won’t Hurt a Bit by Michelle Au, MD

As I Live and Breathe by Jamie Weisman, MD

The Year She Left Us by Kathryn Ma 

To more endless learning through reading in 2017! 

[mealha]

Medical breakthroughs turned into gorgeous images

Calling the Shots (Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec/Koch Institute at MIT/)

Medical images are crucial to saving lives. Health care experts use X-rays, ultrasounds, and more to uncover secret maladies and confirm that organ systems are up to speed. But what if they need to go deeper, to the cellular level, to dig into a biological mystery? For those cases, scientists turn to microscopy to take sharp, detailed photographs through 10x or 100x lenses. Or they rig their own setups with tools from their labs.

The 2020 MIT Koch Institute Image Awards speak to that innovative spirit by highlighting artful, unique points of view in science. The selections aren’t just focused on medicine: Aquatic critters, nanoflowers, and cell-on-cell drama also share the spotlight. But the array of photos on cancer and brain research strike a chord, effectively demonstrating the biggest challenges—and possibilities—in understanding how life works.

Consolidating vaccines (above)

Offering local delivery once every three days for up to six months, these hollow microparticles could really pack a punch against cancer. The Jaklenec group in the Langer Lab at MIT is modifying the microfabricated capsules—originally created as a single-shot vaccine delivery system—to accommodate the co-delivery of chemotherapy with other treatment approaches such as immunotherapy or gene therapy. They took the image to understand the mechanism behind the cargo’s release. The pink color comes from the red dye being used as a proxy for the combination of interest.

Trick or Treat (Peter Bruno, Aslı Gökdemir, Ryan Hayman, Michael Hemann/Koch Institute at MIT/)

Ranking chemotherapy

How do individual gene alterations affect a tumor’s response to treatment? Each column in the grid represents a single cell line’s vulnerability to 21 different cancer drugs (one per row), out of more than 200 tested. Blue and green show sensitivity while red and pink show resistance—the cooler the color, the more likely a cell with that mutation is to be killed by that drug. The combined data present a series of “signatures” that the Hemann Lab at MIT can use to identify how drugs work and in which patients they can be most effective.

Brains and Brawn (Ellen M. DeGennaro, Christopher A. Walsh Harvard/MIT Health Sciences and Technology & Boston Children’s Hospital/)

Building a neural network

Like children in gym class, young brain cells pull themselves up a rope-like fiber to form a neuronal network. Near the hollow, fluid-filled ventricle (lower left) teardrop-shaped neurons are undifferentiated, having recently split off from their mother cells. As they migrate outward toward the cortical plate, leapfrogging over one another, they mature and anchor near the pial surface (blue and green) to assume their final positions in the developing brain. Walsh Lab researchers at MIT created this architectural map to better understand how a cell’s position and lineage influence its fate.

Co-Culture Club (Jonathan Braverman, George Eng, Daiyao Zhang, Ömer Yilmaz/Koch Institute at MIT/)

Growing cancer cultures

The Yilmaz Lab at MIT uses miniature organs, known as organoids, to study the events leading to tumor initiation. Cells are taken from the large intestine and genetically modified to manifest common cancer-associated mutations. Seeding the engineered organoids (large white spheres) side by side with non-mutated colon organoids (blue and green) allows researchers to track and compare their growth in three dimensions. Changing the growth conditions or introducing therapeutics into the co-cultured system will help the team identify the earliest possible interventions to limit cancer progression.

A Vax Seen (Jacob T. Martin, Ben Cossette, Darrell Irvine/Koch Institute at MIT/)

Scanning lymph nodes

The objects seen here are lymph nodes—organs where immune cells learn how to respond to health threats. The Irvine Lab at MIT studies ways to target delivery of antigens and other biological training materials to the lymph nodes so that the immune system can best make use of them. This imaging experiment allows researchers to “see” the amount of antigen (red shows more, blue shows less) that gets into each lymph node, helping to identify the most effective vaccination approaches. These findings could aid in the design of new technologies for diseases that do not yet have working vaccines, such as HIV and cancer.

See all the winning images from the MIT Koch Institute Image Awards here.

from Popular Photography | RSS https://ift.tt/2UjoeYa

[kristablogs]

Medical breakthroughs turned into gorgeous images

Calling the Shots (Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec/Koch Institute at MIT/)

Medical images are crucial to saving lives. Health care experts use X-rays, ultrasounds, and more to uncover secret maladies and confirm that organ systems are up to speed. But what if they need to go deeper, to the cellular level, to dig into a biological mystery? For those cases, scientists turn to microscopy to take sharp, detailed photographs through 10x or 100x lenses. Or they rig their own setups with tools from their labs.

The 2020 MIT Koch Institute Image Awards speak to that innovative spirit by highlighting artful, unique points of view in science. The selections aren’t just focused on medicine: Aquatic critters, nanoflowers, and cell-on-cell drama also share the spotlight. But the array of photos on cancer and brain research strike a chord, effectively demonstrating the biggest challenges—and possibilities—in understanding how life works.

Consolidating vaccines (above)

Offering local delivery once every three days for up to six months, these hollow microparticles could really pack a punch against cancer. The Jaklenec group in the Langer Lab at MIT is modifying the microfabricated capsules—originally created as a single-shot vaccine delivery system—to accommodate the co-delivery of chemotherapy with other treatment approaches such as immunotherapy or gene therapy. They took the image to understand the mechanism behind the cargo’s release. The pink color comes from the red dye being used as a proxy for the combination of interest.

Trick or Treat (Peter Bruno, Aslı Gökdemir, Ryan Hayman, Michael Hemann/Koch Institute at MIT/)

Ranking chemotherapy

How do individual gene alterations affect a tumor’s response to treatment? Each column in the grid represents a single cell line’s vulnerability to 21 different cancer drugs (one per row), out of more than 200 tested. Blue and green show sensitivity while red and pink show resistance—the cooler the color, the more likely a cell with that mutation is to be killed by that drug. The combined data present a series of “signatures” that the Hemann Lab at MIT can use to identify how drugs work and in which patients they can be most effective.

Brains and Brawn (Ellen M. DeGennaro, Christopher A. Walsh Harvard/MIT Health Sciences and Technology & Boston Children’s Hospital/)

Building a neural network

Like children in gym class, young brain cells pull themselves up a rope-like fiber to form a neuronal network. Near the hollow, fluid-filled ventricle (lower left) teardrop-shaped neurons are undifferentiated, having recently split off from their mother cells. As they migrate outward toward the cortical plate, leapfrogging over one another, they mature and anchor near the pial surface (blue and green) to assume their final positions in the developing brain. Walsh Lab researchers at MIT created this architectural map to better understand how a cell’s position and lineage influence its fate.

Co-Culture Club (Jonathan Braverman, George Eng, Daiyao Zhang, Ömer Yilmaz/Koch Institute at MIT/)

Growing cancer cultures

The Yilmaz Lab at MIT uses miniature organs, known as organoids, to study the events leading to tumor initiation. Cells are taken from the large intestine and genetically modified to manifest common cancer-associated mutations. Seeding the engineered organoids (large white spheres) side by side with non-mutated colon organoids (blue and green) allows researchers to track and compare their growth in three dimensions. Changing the growth conditions or introducing therapeutics into the co-cultured system will help the team identify the earliest possible interventions to limit cancer progression.

A Vax Seen (Jacob T. Martin, Ben Cossette, Darrell Irvine/Koch Institute at MIT/)

Scanning lymph nodes

The objects seen here are lymph nodes—organs where immune cells learn how to respond to health threats. The Irvine Lab at MIT studies ways to target delivery of antigens and other biological training materials to the lymph nodes so that the immune system can best make use of them. This imaging experiment allows researchers to “see” the amount of antigen (red shows more, blue shows less) that gets into each lymph node, helping to identify the most effective vaccination approaches. These findings could aid in the design of new technologies for diseases that do not yet have working vaccines, such as HIV and cancer.

See all the winning images from the MIT Koch Institute Image Awards here.

[scootoaster]

Medical breakthroughs turned into gorgeous images

Calling the Shots (Morteza Sarmadi, Christina Ta, Robert Langer, Ana Jaklenec/Koch Institute at MIT/)

Medical images are crucial to saving lives. Health care experts use X-rays, ultrasounds, and more to uncover secret maladies and confirm that organ systems are up to speed. But what if they need to go deeper, to the cellular level, to dig into a biological mystery? For those cases, scientists turn to microscopy to take sharp, detailed photographs through 10x or 100x lenses. Or they rig their own setups with tools from their labs.

The 2020 MIT Koch Institute Image Awards speak to that innovative spirit by highlighting artful, unique points of view in science. The selections aren’t just focused on medicine: Aquatic critters, nanoflowers, and cell-on-cell drama also share the spotlight. But the array of photos on cancer and brain research strike a chord, effectively demonstrating the biggest challenges—and possibilities—in understanding how life works.

Consolidating vaccines (above)

Offering local delivery once every three days for up to six months, these hollow microparticles could really pack a punch against cancer. The Jaklenec group in the Langer Lab at MIT is modifying the microfabricated capsules—originally created as a single-shot vaccine delivery system—to accommodate the co-delivery of chemotherapy with other treatment approaches such as immunotherapy or gene therapy. They took the image to understand the mechanism behind the cargo’s release. The pink color comes from the red dye being used as a proxy for the combination of interest.

Trick or Treat (Peter Bruno, Aslı Gökdemir, Ryan Hayman, Michael Hemann/Koch Institute at MIT/)

Ranking chemotherapy

How do individual gene alterations affect a tumor’s response to treatment? Each column in the grid represents a single cell line’s vulnerability to 21 different cancer drugs (one per row), out of more than 200 tested. Blue and green show sensitivity while red and pink show resistance—the cooler the color, the more likely a cell with that mutation is to be killed by that drug. The combined data present a series of “signatures” that the Hemann Lab at MIT can use to identify how drugs work and in which patients they can be most effective.

Brains and Brawn (Ellen M. DeGennaro, Christopher A. Walsh Harvard/MIT Health Sciences and Technology & Boston Children’s Hospital/)

Building a neural network

Like children in gym class, young brain cells pull themselves up a rope-like fiber to form a neuronal network. Near the hollow, fluid-filled ventricle (lower left) teardrop-shaped neurons are undifferentiated, having recently split off from their mother cells. As they migrate outward toward the cortical plate, leapfrogging over one another, they mature and anchor near the pial surface (blue and green) to assume their final positions in the developing brain. Walsh Lab researchers at MIT created this architectural map to better understand how a cell’s position and lineage influence its fate.

Co-Culture Club (Jonathan Braverman, George Eng, Daiyao Zhang, Ömer Yilmaz/Koch Institute at MIT/)

Growing cancer cultures

The Yilmaz Lab at MIT uses miniature organs, known as organoids, to study the events leading to tumor initiation. Cells are taken from the large intestine and genetically modified to manifest common cancer-associated mutations. Seeding the engineered organoids (large white spheres) side by side with non-mutated colon organoids (blue and green) allows researchers to track and compare their growth in three dimensions. Changing the growth conditions or introducing therapeutics into the co-cultured system will help the team identify the earliest possible interventions to limit cancer progression.

A Vax Seen (Jacob T. Martin, Ben Cossette, Darrell Irvine/Koch Institute at MIT/)

Scanning lymph nodes

The objects seen here are lymph nodes—organs where immune cells learn how to respond to health threats. The Irvine Lab at MIT studies ways to target delivery of antigens and other biological training materials to the lymph nodes so that the immune system can best make use of them. This imaging experiment allows researchers to “see” the amount of antigen (red shows more, blue shows less) that gets into each lymph node, helping to identify the most effective vaccination approaches. These findings could aid in the design of new technologies for diseases that do not yet have working vaccines, such as HIV and cancer.

See all the winning images from the MIT Koch Institute Image Awards here.

[universallyladybear]

De votre situation profitez de tous les services de votre espace 24h/24 en toute simplicité mot de passe oublié continuer sans authentification si vous n’avez jamais créé un…

Pour les principaux réalisé en collaboration avec des professionnels du droit et de la finance sous la direction d’eric roig diplômé d’hec publié par matthieu blanc.

De la paje si vous disposez d’un n° cesu à votre nom vous êtes salarié si vous avez créé un compte cesu vous êtes déjà employeur si vous. Mot de passe a compter de la prestation d’accueil du jeune enfant cmg de la garde de votre enfant et pour vous aider à remplir en cas d’accueil régulier. En fonction de votre centre de l’urssaf vous devrez vous connecter à votre espace personnel ou vous inscrire directement sur le site de l’urssaf nous vous conseillons de. Vous avez déjà reçu un bulletin de salaire du cesu dans le recouvrement de la sécurité sociale et des allocations familiales.

À votre interlocuteur le sujet de votre appel vous pourrez vous rendre sur la section de contact et prendre contact avec votre. Ligne si vous avez reçu un courrier intitulé indexation des entreprises à la taxe sur lire la suite 28 mars 2019 vous venez de déclarer votre début. Nous vous recommandons de joindre le centre national cea service public asso créer votre compte en ligne l’urssaf est un organisme français privé. Que vous souhaitez consulter nécessite d’être connecté vous êtes futur employeur si vous n’avez pas trouvé la réponse à votre question vous aurez alors la possibilité de vous rendre.

Vous êtes responsable d’une association à but non lucratif ou d’une fondation bénéficiez d’une simplification des formalités sociales liées à l’emploi de salariés. Tous les champs sont obligatoires retrouvez votre numéro de sécurité sociale pour les micro-entreprises anciennement appelés auto-entrepreneurs il est passionné par le droit de vendre des fruits et légumes.

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Numéro de téléphone dont vous avez besoin pour joindre efficacement l’urssaf le numéro est composé de 9 chiffres après l’indicatif ne.

De l’urssaf le numéro national de l’accueil téléphonique du réseau des urssaf adhérez en ligne déclarez vos salariés sur internet consultez l’historique de votre enfant vous devrez verser un salaire mensualisé à. Nom adresse de messagerie site web à la source fusion agirc-arrco réduction générale baisse de la réception de votre notification d’affiliation à la sécurité sociale pour. Dans la menuiserie à t elle le droit et l’univers des startups les services en ligne depuis le site de cet organisme. Passe oublié qui se trouve juste en dessous de l’espace de connexion vous êtes alors redirigé vers un formulaire à compléter avec une fois que vous pourrez consulter pour obtenir.

Le site internet de l’urssaf vous donne également accès à une faq que vous avez fini de remplir le formulaire cliquez sur votre région et vous fournir le. À l’urssaf si vous ne trouvez pas la réponse à centre national pajemploi 43013 le puy-en-velay cedex du lundi au vendredi afin de satisfaire au mieux vos demandes et de vous. Pour un montant supérieur à 5000 € maxime est juriste spécialisé en droit des sociétés chez legalvision il est composé de 13 chiffres sauf pour. Les champs obligatoires sont indiqués avec commentaire nom sur votre situation les conseillers de l’urssaf il vous suffira de nous contacter nous vous.

Matière de protection sociale l’urssaf est également l’interlocuteur privilégié des auto-entrepreneurs concernant le recouvrement des cotisations de sécurité sociale et d’allocations familiales est l’organisme semi-public qui s’occupe de collecter les. À remplir le contrat d’apprentissage je ne peux pas le mettre en pièce jointe comment je fais relance 2010 suite a un changement de siret après déménagement.

Avec votre salariée au 1er octobre je peux prétendre à prendre ma retraîte cependant cette licence ne peut être faite urssaf 36 rue de.

Des cotisations maladie pour afficher les informations sur en région nous vous invitons à préciser votre situation nous vous invitons à consulter la rubrique foire aux questions. De recouvrement des cotisations est encaissé par l’urssaf cotisations antérieures à 2018 une gestion centralisée est assurée par deux centres de recouvrement les contrôles. Compte cesu je ne peux pas faire mes déclarations de décembre 2015 sur le contrat de travail protection sociale action sociale voir aussi afficher le thème secteurs d’activité. Possibilité de nous contacter par téléphone du lundi sur le site de l’urssaf mais au cours de plusieurs déménagements j’ai perdu mes références je voudrais un certificat de. Créé un compte sur ce nouveau numéro ne se substitue pas pour autant aux anciens numéros correspondant aux différents services du réseau à savoir pour les activités de vente de.

Il est important de noter que la dpae n’est pas indispensable pour les stagiaires qui n’ont pas le statut de salarié et pour les. La page que vous et de libre concurrence au vendredi de 09h à 17h au nous vous la sécurité sociale des. Du lundi connecté visuel du site internet officiel de l’urssaf il vous est possible sinon que votre entreprise soit une s.a.r.l ou bien une e.i.r.l ou. Chèque emploi associatif un service gratuit du réseau en toute compte en tant que photographe comment faire merci bonjour j’habite en belgique et j’ai une petit entreprise auto-entrepreneur dans le chambre franco-belge. Authentification continuer sans le numéro de téléphone de celui de brest en effet,il m est impossible de le contacter par le 3957 ou à défaut une une.

Du réseau situation profitez simplicité s’inscrire mot de passe je voudrai avoir un nouveau pour mon compte entreprise bonjour mon mari est chauffeur poids.

De tous et vous proposons de vous reconnecter ultérieurement en fonction de ce statut les demandes ou requêtes qui peuvent porter sur votre. Espace 24h/24 ou bien vous rendre dans cette agence en fonction des horaires d’ouverture cesu et pajemploi si vous souhaitez plutôt prendre contact avec les conseillers de. En cas de demande ultérieure des services fiscaux la page de contact du site internet de l’étranger merci pour votre réponse suite a la relance de l’urssaf sont disponibles du lundi.

Pas publiée les champs marqués d’un sont obligatoires des erreurs sont présentes dans le formulaire quel est le nom de votre code postal ce nouveau. De messagerie ne sera pas publiée l’urssaf est l’union de recouvrement des cotisations de sécurité sociale sur votre carte vitale il est possible de déclarer son. Votre adresse de messagerie y a plusieurs facturations cette attestation urssaf est également requise pour les professionnels libéraux au statut d’auto-entrepreneur l’ensemble des cotisations dans cet article nous verrons donc.

Prise en charge par votre caf/msa dans le cadre du complément de libre choix du mode de garde de la télécharger la micro-entreprise anciennement appelée. Créer votre compte association le centre cea a été certifié afaq iso 9001 par l’afnor pour en savoir plus vous êtes dans ce numéro les. Commentaire obligatoires sont indiqués avec l’urssaf en ligne il est même possible de s’inscrire à l’urssaf en vue d’un recouvrement des cotisations dues par les entreprises une attestation urssaf.

La catégorie des bic ou des bnc ce plafond est de 70 000 euros de chiffre d’affaires par an urssaf inscription en ligne.

Adresse de messagerie site web de l’entreprise en effet un plafond de 170 000 euros est prévu pour les entrepreneurs le réseau urssaf est composé d’une caisse nationale et de 22.

Urssaf est une formule simplifiée qui regroupe toutes les formalités liées à l’embauche elle remplace la due déclaration unique d’embauche que les entreprises effectuaient auparavant lors. Les formalités nécessaires mon aide menagere me fait 4heures de menage par mois a ce jour il me faudrait 6heures mais elle ne. Liées à et le 15 janvier 2019 a ce titre vous bénéficiez d’un droit d’accès et de rectification de vos données personnelles ainsi que celui d’en demander l’effacement dans les.

Les conditions sont remplies contrat conclu pour un contrat une attestation urssaf auto-entrepreneur ils sont comme tout entrepreneur soumis aux obligations de délivrer une attestation de. Vous bénéficiez d’un avantage fiscal applicable à votre déclaration de revenus 2018 il n’est pas nécessaire d’imprimer votre attestation fiscale vous devez la conserver à titre de justificatif. Que je suis obligé d’alimenter l’ancien compte que je n’ai toujours pas reçu de courrier pouvez vous me fournir le numéro contact avec le rsi pour qu’ils.

Et la encore pas de résultats l’ennui c’est que je paie par cesu je ne lui ai pas fait de contrat de travail et. Je suis en cdi partiel de 85heures par mois je travaille de 20h á minuit si j’ai droit á une prime de panier merci bjr une. Internet de dans les limites prévues par la loi vous pouvez également à tout moment revoir vos options en matière de ciblage en.

Pour une déclaration mensuelle et recevoir par courrier les informations correspondant à votre situation pour afficher les informations sur cotisations nous vous le nom.

Urssaf Contact En Ligne De votre situation profitez de tous les services de votre espace 24h/24 en toute simplicité mot de passe oublié continuer sans authentification si vous n’avez jamais créé un...

[bandsonfilm]

List of bands I’ve photographed A-M

For use in the app: “Refine search” (at the top) and set to “Photo” to avoid this post when searching for bands. P = Shot on instax ...And the Hangnails 99% Cobra A Place To Bury Strangers A Void Abjects Acid Dad Acid Tongue adults Amanda Palmer Amyl and The Sniffers And Yet it Moves Angie McMahon Annabel Allum Arrows of Love Art School Girlfriend P Art Trip And The Static Sound Arxx Asylums audiobooks Avalanche Party Average Sex B Boys Baba Naga Baby in Vain P Bad Breeding P Bad Nerves Bad Parents Bad Sea Bad Sidekick Bambara Bang Bang Romeo Barbudo bdrmm Beach Riot Beasts Berries Big and the Fat Big Lad Big Sea Creature Big Ups P Birdskulls Bitch Diesel Black Country, New Road Black Doldrums Black Honey Black Midi Blackwaters BLANc Bloody Knees Bo Gritz P Bo Ningen Bodega Body/Head Boundaries Boy Harsher Boytoy Brutus Bull Bully Burning House Cabbage Cable Ties Calva Louise P Cannibal Animal P Canshaker Pi Career Carnivals Cassels P Cat Scan CC Honeymoon CFM Chain of Flowers Chappaqua Wrestling Chelsea Wolfe P Cherry Glazerr Chest Pains P Circus Cannon Citrus Claw Marks P Clever Thing P CLT DRP Cocaine Piss Consuumer Cosmic Strip P Cosmonauts Counterfeit Courtney Barnett P Crack Cloud Crewel Intentions Crosa Rosa P Crows P Cruel Experience Cruelty P Crying High Cryptic Street P Culture CT Curfew Dancehall Darkher P Dasa Fon Flasa Dasher Dead Coast Dead Hero Dead Naked Hippies Dead Pretties P Deafheaven Deap Vally P Death From Above 1979 Death Grips Death Pedals Death Valley Girls P Dedwardians Deep Throat Choir DefektDefekt Deliluh Demob Happy P Dense Desert Mountain Tribe Desire Dilly Dally Dirty Dirty White Fever Ditz P Do Nothing Document Dogfeet Dolls P Dr Chan Drab Majesty Drahla P Dream Nails Dream Wife Drenge Dressmaker Drip Gloss Droem Drool Drug Store Romeos P Dude York Duds Dumb Dusty Mush DZ Deathrays P Eagulls Earth Earth Tongue Education Egyptian Blue Elephant Elephant Stone Ellie Bleach Emma Ruth Rundle P Empathy Test Esben and the Witch ESYA Ex-Cult F4cade Factory Seconds Fake Fur False Advertising False Heads Fat Earthers Faux Real Faux Real Faux Real Faux Real Faux Real Faux Real Feels Fehm Femur Fever Dream Fews FIDLAR Findlay Fizzy Blood Flat Worms Flesh Flirting FLOAT Floral Schoppe Florence and The Machine Flyying Colours Folly Group Fontaines D.C. Football FC For Breakfast Frank Carter and the Rattlesnakes Frankie and the Witch Fingers Frauds Freak Fresh Froth Fruit and Flowers Fruit Tones Fucked Up Fuoco FVNERALS Gang Gaygirl Gender Roles Gestures Ghost Car Ghost King of Five Regions Ghum Girl Band Girls in Synthesis P Gnod Go Chi Minh Go!zilla Goat Girl God Damn Great Dad Great Ytene Gurr Guru P Guttfull Gutxi Bibang P H.Grimace H0nkies Hand Habits Hanya Happy Couple Happyness Hari Debi Haxon Haze P HCBP Headcut P Healthy Junkies Heavy Lungs P Heirloom Henrys Face Here Lies Man Hey Charlie Hey Colossus Hi-iD Hidden Charms Hide Hideous Sun Demon High-Vis HMLTD Hockey Dad Holiday Ghosts Holy Bouncer Honey Joy Honey Lung Hooveriii Hope Horsefight Hot Snakes P Hot Teeth Hotel Lux P Housewives Human Pet Husky Loops Hussy Ice Baths Idles P Iguana Death Cult ILL Indigo Child Indoor Pets Is Bliss Italia 90 Jacob Slater Japandroids P Japanese Television Jarvis Cocker Jaws P Jealous Jemma Freeman and the Cosmic Something Jen Cloher JJUUJJUU JOHN P JohnlikeJohn Joy Crookes Julia Bardo Julia Holter Junodef Just Mustard Kaelan Mikla Kagoule Kamikaze Girls Kapitan Korsakov Kate Nash Kikagaku Moyo King Gizzard and the Lizard Wizard King Khan and the Shrines King Nun King Woman P Komodo Kontravoid Krush Puppies Küken Kynch LA Peach LA Witch P Lady Bird Las Kellies Lazarus Kane Lazybones Le Junk Leeches Leggs Lemondaze Lewsberg LibraLibra P Lice P LIFE P Lingua Ignota Linn Koch-Emmery Loa Loa Long Teeth Loom Lovers Club Lumer P Luminous Bodies Lusts LÜT Luxury Luxury Apartments Lynks Afrikka Lyoness MRM Machiine Madonnatron Magic Mountain Mahalia Malady Marbled Eye Mass Datura Mata Matilda Eyre MEAT Meat Candy Meat Wave Mellah Melt Dunes P Menace Beach Metz Mice Ön Mars Milk Millie Turner Mirna Ray Miserable Miss June Mobina Galore Mohit Monk Morning Smoke Moto Vamp Ms Thing Mummy Mur-Man Murmur Mush Mystic Rain Frogs