#Latest Medical Technology News

[techmezine2019]

Examining Electronics Component News and Latest Medical Technology News via Techmezine helps one gain insights.

Constant innovation in the IT sector is driven in part by Electronics Component News. Professionals must remain current with new items and technologies constantly being unveiled. From the most recent semiconductors to microcontroller innovations, these changes define the direction of technology and affect everything from consumer devices to industrial uses.

Revolutionizing Healthcare with the Most Current Medical Technology News

The  Latest Medical Technology News emphasizes the innovations transforming healthcare. Advanced medical technologies, wearable health monitors, and AI-driven diagnostics are altering the way healthcare is provided and thereby increasing its efficiency and patient-centric nature. Both tech aficionados and medical professionals should keep current with these changes since they significantly affect patient treatment outcomes and quality of life.

Keep Ahead with Techmezine's All-Inclusive Coverage

At Techmezine, we are dedicated to giving thorough coverage of Latest Medical Technology News and Electronics Component News. To keep competitive and informed, our platform provides thorough insights into the newest trends, product introductions, and market studies. Our goal in emphasizing the technical features of new components and medical technologies is to equip our readers with the information required to succeed in their particular domains.

Conclusion: Value of Maintaining Information

Maintaining knowledge of Electronics Component News and Latest Medical Technology News is vital in the fast changing environment of today. Your first choice for factual, timely, and perceptive material bridging the gap between technology and healthcare is techmezine. Whether your background is in industry, research, or just a love of technology, our platform offers the knowledge you need to succeed in these exciting disciplines.

[reasonsforhope]

Article | Paywall Free

"The Food and Drug Administration approved new mRNA coronavirus vaccines Thursday [August 22, 2024], clearing the way for shots manufactured by Pfizer-BioNTech and Moderna to start hitting pharmacy shelves and doctor’s offices within a week.

Health officials encourage annual vaccination against the coronavirus, similar to yearly flu shots. Everyone 6 months and older should receive a new vaccine, the Centers for Disease Control and Prevention recommends.

The FDA has yet to approve an updated vaccine from Novavax, which uses a more conventional vaccine development method but has faced financial challenges.

Our scientific understanding of coronavirus vaccines has evolved since they debuted in late 2020. Here’s what to know about the new vaccines.

Why are there new vaccines?

The coronavirus keeps evolving to overcome our immune defenses, and the shield offered by vaccines weakens over time. That’s why federal health officials want people to get an annual updated coronavirus vaccine designed to target the latest variants. They approve them for release in late summer or early fall to coincide with flu shots that Americans are already used to getting.

The underlying vaccine technology and manufacturing process are the same, but components change to account for how the virus morphs. The new vaccines target the KP.2 variant because most recent covid cases are caused by that strain or closely related ones...

Do the vaccines prevent infection?

You probably know by now that vaccinated people can still get covid. But the shots do offer some protection against infection, just not the kind of protection you get from highly effective vaccines for other diseases such as measles.

The 2023-2024 vaccine provided 54 percent increased protection against symptomatic covid infections, according to a CDC study of people who tested for the coronavirus at pharmacies during the first four months after that year’s shot was released...

A nasal vaccine could be better at stopping infections outright by increasing immunity where they take hold, and one is being studied in a trial sponsored by the National Institutes of Health.

If you really want to dodge covid, don’t rely on the vaccine alone and take other precautions such as masking or avoiding crowds...

Do the vaccines help prevent transmission?

You may remember from early coverage of coronavirus vaccines that it was unclear whether shots would reduce transmission. Now, scientists say the answer is yes — even if you’re actively shedding virus.

That’s because the vaccine creates antibodies that reduce the amount of virus entering your cells, limiting how much the virus can replicate and make you even sicker. When vaccination prevents symptoms such as coughing and sneezing, people expel fewer respiratory droplets carrying the virus. When it reduces the viral load in an infected person, people become less contagious.

That’s why Peter Hotez, a physician and co-director of the Texas Children’s Hospital Center for Vaccine Development, said he feels more comfortable in a crowded medical conference, where attendees are probably up to date on their vaccines, than in a crowded airport.

“By having so many vaccinated people, it’s decreasing the number of days you are shedding virus if you get a breakthrough infection, and it decreases the amount of virus you are shedding,” Hotez said.

Do vaccines prevent long covid?

While the threat of acute serious respiratory covid disease has faded, developing the lingering symptoms of “long covid” remains a concern for people who have had even mild cases. The CDC says vaccination is the “best available tool” to reduce the risk of long covid in children and adults. The exact mechanism is unclear, but experts theorize that vaccines help by reducing the severity of illness, which is a major risk factor for long covid.

When is the best time to get a new coronavirus vaccine?

It depends on your circumstances, including risk factors for severe disease, when you were last infected or vaccinated, and plans for the months ahead. It’s best to talk these issues through with a doctor.

If you are at high risk and have not recently been vaccinated or infected, you may want to get a shot as soon as possible while cases remain high. The summer wave has shown signs of peaking, but cases can still be elevated and take weeks to return to low levels. It’s hard to predict when a winter wave will begin....

Where do I find vaccines?

CVS said its expects to start administering them within days, and Walgreens said that it would start scheduling appointments to receive shots after Sept. 6 and that customers can walk in before then.

Availability at doctor’s offices might take longer. Finding shots for infants and toddlers could be more difficult because many pharmacies do not administer them and not every pediatrician’s office will stock them given low demand and limited storage space.

This year’s updated coronavirus vaccines are supposed to have a longer shelf life, which eases the financial pressures of stocking them.

The CDC plans to relaunch its vaccine locator when the new vaccines are widely available, and similar services are offered by Moderna and Pfizer."

-via The Washington Post, August 22, 2024

[thylacinetears]

UPDATED GEMINITAY RESUME

I've seem a couple people remark on how crazy IRL Gem's lore/accomplishments are. She just dumped a whole bunch of new information in the latest stream (link here) so I thought I'd make an updated list of IRL GeminiTay lore:

Degree in marine biology

Degree in medical lab technology

Was a figure skater

Did a course in coaching figure skating

Worked at a Goodwill food bank

Worked in a museum as an archivist assistant

Worked as a tour guide

Worked at a gift shop

Can play piano

And of course, Minecraft Youtuber with 1.8 million subscribers on her main channel, and 100k subscribers on her second channel.

Someone needs to study why all the Hermits have such crazy and impressive lives outside of MCYT lmao

[celestiamour]

‧₊˚✧ ❛[ newfangled technology ]❜

ft. logan howlett x f! reader — xmen, marvel

╰₊✧ logan finds your vibrator and discovers a wonder of modern technology┊1k words

contains: smut!! dom logan & sub reader┊implied age gap, established relationship, vibrators, overstimulation & mentioned multiple orgasms, receiving oral

➤ author's note: first logan smut!! i’m a bit burnt out of writing it actually so idk if there will be more, but i couldn’t let this idea go <3

logan likes to believe that he understands modern technology for the most part even though you can often hear him muttering curses under his breath at the stupid machine that isn’t working. if most parents and grandparents are struggling to figure it all out, you can bet that this two-hundred-year-old mutant does. it feels like yesterday when people were using rotary phones in their homes, then hand-held flip-phones, and now smartphones that could show you anything you could dream of at the tap of a button— he feels as though the world is growing much faster than an old man like him can keep up with too many gadgets for too many different purposes getting too many upgrades.

any attempts to get him to understand the internet fail for the most part, so he uses his own phone for nothing other than calling, texting, photography, and occasionally googling some sort of questions. he finds advertisements about the latest devices annoying, but he’s very appreciative of motorcycles, kitchen appliances, and other simple machines that make life so much easier compared to his time.

he’s learning about new tech every week, new and pre-existing, both ones which make him wonder if he should get it for himself or ones which make him furrow his brow at the fact that such a thing actually exists. tonight is one of the times when he has both reactions, but more than anything, an intense curiosity had been ignited in his soul.

you asked him to look for something in your bedroom drawers, something that he can’t recall at the moment after he found something that piqued his attention: an egg-shaped item coated in pink medical-grade silicone neatly hidden under layers of clothing and tightly wrapped in a bag. it was tiny in his massive hand and he didn’t have the foggiest idea what it was or what it was made for until you walked in to see what was taking so long, hearing you gasp and turning his head to find you covering your face with your hands looking absolutely mortified. you struggled to stop yourself from stuttering when you had to explain to him what it was, a sex toy that you bought sometime in the first year of college and buried once you got together since it was no longer needed. it was the only one you’ve ever bought and you’ve honestly forgotten about it until now without any idea of how he would react.

while you were humiliated about it, you could see a sparkle of intrigue in his eyes which quickly led to finding yourself in bed with your clothing removed and his new discovery against your aching cunt. it wasn’t difficult to figure out how to change the intensity of the vibrations with a press of a button, but did he need to put it at the highest setting when you’ve practically lost feeling in your legs at this point? it felt so strange at first now that you’re so accustomed to him pleasuring you personally, yet that foreign sense melted away with the familiar memory of taking care of your needs when lonely— except now you had your handsome lover holding it for you with your hands gripping the sheets instead. 

he’s amused at how such a small little thing was so powerful in reducing you to a moaning mess as it pulls another orgasm from your spent body, feeling his neglected cock twitch with every blissful moan past your lips louder than the humming of the toy. you mutter something along the lines of asking him not to stare out of embarrassment, but it all falls on deaf ears since the view that he has is downright mesmerizing, watching intently as he presses it into your puffy folds with a focus on your sensitive clit. all the while, he’s holding your legs open to stop you from closing them instinctively when it felt like too much, his large hand being a comforting weight on your thigh as you squirm in place.

your body trembled in sync with the pulsating toy, walls barely able to clench around the head of the vibrator while leaking like a faucet and dripping all over logan’s fingers. “it’s too much-!!” you whined, throwing your head back into the pillows with glossy eyes and drool starting to seep out the corner of your mouth from the electricity coursing through your veins. it’s surprising that you were even able to utter a coherent phrase when your brain had essentially been turned to mush.

“you can give me one more, can’t you doll?” there’s a hint of sadism in his voice detectable to even your ecstasy-fogged mind where you knew that he was getting off on your reactions alone, an arrogant smirk plastered across his handsome face that was so slappable and sexy. he can almost feel himself drooling too, craving a taste of the sweet nectar making a mess everywhere. “such a desperate and needy little thing,” he tutted, observing your greedy pussy trying to pull the vibrator deeper within you. “go on, cum for me.”

as if his words commanded your body, the tight coil twisting in your abdomen finally snapped, making you writhe and cry out in relief. your heart was pounding in your chest and you gasped for air, feeling sweaty and exhausted as that must have been your third or fourth climax. you stared at him through half-lidded eyes trying to determine if he had had enough of using the vibrator for torturous pleasure until he suddenly pulled you closer to him to bury his face into your soaked heat. he just needed a taste of you, to lick you clean and make you tug on his hair.

watching you become undone when he doesn’t even need to lift a finger seemed to awaken something in him… it’s definitely a piece of modern technology that he would like to invest in, he plans to buy more of different types, shapes, and sizes to try out on you (the definition of “spectacular, give me fourteen of them right now”).

[blockchainnewsme]

New Hernia Treatments Were Presented At A Medical Conference In Riyadh

Riyadh hosted a major international medical conference on hernias, where cutting-edge techniques like laparoscopy and robotic-assisted surgery were discussed as effective means of care for patients. There were more than 300 surgeons from the Kingdom and Arab countries news who specialize in hernias, as well as more than 300 healthcare workers, speakers, and officials, in attendance. Studies show…

[radioactive-reactions]

How would the companions react to discovering not only Vault 111 but also the frozen Sole Survivor

Whether they saw it as a potential treasure trove, a nostalgic relic, or just a safe, quiet refuge, Vault 111 always seemed to attract the odd scavenger or adventurer. After slipping past the door, however, this particular intruder would end up stumbling upon something far stranger than they could expect...

Cait hadn't really taken the time to scope out the Vault before diving into it headfirst- having a pack of feral dogs nipping at your heels will do that to you. Coming face to face with the frozen Sole Survivor down there is freaky enough to give her a heart attack, but as the perfect audience for her rambling stories and a nonjudgmental drinking buddy they soon become the centerpiece of her impromptu hideout. As for actually getting them out? Fuck if she knows how.

Codsworth knows full well what the Vault up the hill contains, of course. How could he not? Much of the aging robot's time is spent tending to his owners' pods: tightening every bolt, polishing the glass, keeping the steel casing free of even a single speck of rust. The only thing that keeps him going is the thought that on some level, under that thin layer of frost, they might know he's there for them.

Curie's unbridled excitement at making contact with another Vault is quickly tempered once she actually sets eyes on the denizens of said Vault. With nothing but time and centuries' worth of medical expertise to work with, she immediately sets to the task of bringing Vault 111 back to life- not just the Sole Survivor, but everyone consigned to a cold and inglorious fate in those cryopods. This is a mission worth spending another two hundred years on.

Danse has been assigned to scour the Vault as part of a routine sweep for useful technology- a task entirely beneath a Paladin, but what he finds there more than makes up for it. Immediately, a whole field research team is dispatched to the vault and the cryopods are airlifted out one by one. The Sole Survivor's first memory of the new world is waking up to the harsh white light of a Brotherhood lab, bombarded with questions and shoved blearily through a battery of tests. Not a great first impression.

Deacon still thinks the Vault would make an ideal fallback hideout, even with the rows of corpsicles. The eerie blue glow and residents in cryosleep are pitched to Desdemona as enhancing the ambience, but the suggestion is soundly denied for the Vault's visibility. Even so, Deacon maintains a post outside, just in case one of those poor bastards stumbles out one day.

When Hancock inexplicably wakes up in the Vault after partying a little too hard, he immediately assumes he's still hallucinating- that, or he's been picked up by Zetans. It takes him hours of trying to pry the Sole Survivor's pod open in a hungover haze to finally give up, writing the place off as another of the Old World's many sins and decent subject matter for his next speech.

MacCready almost feels at home in the vast underground chambers of the Vault. Almost. No matter how convenient the Vault is as a last-ditch hideout, its residents creep him out too much to stay there for any real length of time. He tries his hardest to avoid their frozen stares, endlessly grateful that it's them in there and not him.

Valentine relates to the frozen Sole Survivor a little more than he'd like to admit. Two abandoned relics, used to serve a greater purpose and then thrown out like so much junk when they were done. He knows more than anyone what a harsh awakening they're going to have- if they do wake up. Every so often, he'll wander back to check on them, sharing a yarn about his latest case and watching for any progress. On the day that pod does unseal, he'll be there to lend a helping hand... but until then, all he can do is maintain a file. It's one hell of a cold case.

Piper feels a little guilty that her first thought is how good of a story this will make. 'Pod people slumber among us', maybe? She doesn't want to risk the Sole Survivor's life by touching anything, but maybe if she spreads the word someone out there will be able to help them. That's how she justifies it to herself, anyway- now if only there was some concrete link to the Institute she could work in...

Preston has been surveying the area around Sanctuary for potential threats to the burgeoning settlement... and he still isn't entirely sure that this doesn't count as one. It takes a moment to line up the resident registry with the names on Sanctuary's rusted-out mailboxes, but once he does, he has the Vault sealed up again out of respect for those who came before. If he and his scant resources can't help them, he can at least let them rest in peace.

Strong hammers away at the pod to no avail before stomping off in a huff to seek his next victim somewhere else. Canned food clearly isn't his thing.

X6-88 is here for a routine checkup - nothing more, nothing less. Although the Director had been cagey about what exactly he wanted to be kept safe down here, there was nothing X6 wouldn't be prepared for... so he thought, at least. The sight of a person, frozen and contained, gives him a rare moment of pause and elicits an uncomfortable, involuntary comparison to the dormant synths rolling off the assembly line. Nevertheless, he makes sure the cryopod is still functional and returns home, all the while trying to forget their strange resemblance to the Director.

[srbachchan]

DAY 6044

Jalsa, Mumbai Sept 4, 2024 Wed 10:46 pm

Birthday - EF Reeham Ab El Kader Mostafa Husein and EF Hirna Gorecha Thursday, 5 September ..

wishes for this birthday to them from the Ef brigade ..🌺🌺

... when you inaugurate the latest cutting edge medical technologies, you marvel at the ingenious minds of those that discover and experiment with them and make them a valuable tool for those that suffer ..

to mankind and for one that has been enveloped with multiple visits to hospitals , each new invention gives hope for a better tomorrow ..

and we pray , with the humblest demeanour ..

.. and tomorrow is another day at work , so we turn in .. for a better night and an expectant better tomorrow ..🕉

with love and generosity .. ❤️

Amitabh Bachchan

[danikamariewrites]

can i please request azriel x reader who is a brilliant inventor, she is groundbreakingly smart and she comes up with solutions quicker than anyone. She is very known and well-respected for her quick mind through all the courts and lords and courts try to recruit her for reader to be in their courts. She invents the best inventions like:

- a magical mirror that allows users to glimpse other courts and realms during the annual Starfall event, providing a unique and enchanting view of the world beyond their own.

- Enchanted gemstones that can regulate temperature and create pleasant, cool microclimates within Summer Court, making the sweltering summer season more bearable.

- Quills imbued with the magic of the Night Court, which write in a language only decipherable by those who have undergone the Night Court’s trials, ensuring secret communication.

- Cloaks made from enchanted materials that can protect wearers from various magical and physical threats in the dangerous world of Prythian.

- Mechanical attachments for Illyrian warriors that temporarily enhance their flying abilities, allowing for greater maneuverability and speed during aerial combat.

she makes personal devices for the ic aswell. like gauntlets to help enhance hand-to-hand combat or magical swords, and so on❤️❤️ i’m a woman in stem so this is just amazing idead fr

Inventor 

Azriel x reader

A/n: omg anon ur brain is insane, like this is such a good idea!

Warnings: none

Walking in the house Azriel heard you humming from work room. He smiled to himself as he framed the door open. You were sat at your desk working on your latest invention.

Azriel loved your brain. It is a vast, endless sea of ideas and knowledge. Each creation a new unique wave flowing from you. You grew up on the continent and attended a school that encouraged creativity. Once you moved to the Night Court you made a name for yourself.

Every court wanted you to solve their problems or help create something for agriculture or to consult on new medical technology. And of course you’d help. You’d never want anyone to suffer. Once you told Azriel that inventing things to help people, big or small, made you unbelievably happy.

Azriel walked up behind you placing a kiss on the back of your head. You turn to face him and Az jumps, not expecting your giant magnified eyes. Removing your goggles you smile up at your mate. “Hi babe, how was your day?”

“It was good. What are you working?” He asks looking down at what you are currently tinkering on. “Oh, it’s a small light for Nesta. It can attach to her book so she can read in bed without bother Cassian.” You said with a giggle. Azriel rolled his eyes at his brothers childish complaints.

“If this one works I’m going to make ones for Gwyn and Em too. This is the third prototype, I can’t seem to get the button right so fingers crossed it works.” You pick up the small light and click the button.

The small, but bright light illuminates your work space. Your lips break out into a wide grin. As you hold up the light Azriel smiles at you. “That’s amazing my love! Excellent job, Nesta is going to love it.”

Turning it off you set the book light down. “I’m going to get a box for this, will you fly me to the House of Wind so I can give it to Nes?” “Of course love. I’ll wait here for you.” You kissed his cheek and hurried out of your work room.

He looked around in awe of everything hanging or on shelves in the room. Azriel always prided himself on knowing what was knew or what you made improvements on. It was a fun game for him.

Your voice broke him from his thoughts as you tugged him out of the room. Your excitement to deliver something so small to your friend infectious.

[beraberblog]

ESTHETİCHAİRMEXİCO - DRAGON+ (4)

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[clara-the-independent]

Exclusive Interview with Ljudmila Vetrova- Inside Billionaire Nathaniel Thorne's Latest Venture

CLARA: I'm here with my friend Ljudmila Vetrova to talk about the newest venture of reclusive billionaire Nathaniel Thorne- GAMA. Ljudmila, could you let the readers in on the secret- what exactly is this mysterious project about?

LJUDMILA: Sure, Clara! As part of White City's regeneration programme, Nathaniel has teamed up with the Carlise Group to create a cutting-edge medical clinic like no other. Introducing GAMA– a private sanctuary for the discerning, offering not just top-notch medical care and luxurious amenities, but also treatments so innovative they push the envelope of medical science.

CLARA: Wow! Ljudmila, it sounds like GAMA is really taking a proactive approach to healthcare. But can you tell us a bit more about the cutting-edge technology behind this new clinic?

LJUDMILA: Of course! Now, GAMA is not just run by human professionals, it's also aided by an advanced AI system known as KAI – Kronstadt Artificial Intelligence. KAI is the guiding force behind every intricate detail of GAMA, handling everything from calling patients over the PA system to performing complex surgical procedures. Even the doors have a touch of ingenuity, with no keys required- as KAI simply detects the presence of an RFID chip embedded in the clothing of both patients and staff, allowing swift and secure access to the premises. With KAI at the helm, patients and staff alike benefit from streamlined care.

CLARA: A medical AI? That's incredible! I've heard much of the medical technology at GAMA was developed by Kronstadt Industries and the Ether Biotech Corporation, as a cross-disciplinary partnership to create life-saving technology. Is that true?

LJUDMILA: It sure is, Clara! During the COVID-19 pandemic, GAMA even had several departments dedicated to researching the virus, assisting in creating a vaccine with multiple companies. From doctors to nurses and administrative personnel, the team at GAMA is comprised of skilled individuals who are committed to providing the best care possible. All of the GAMA staff are highly educated with advanced degrees and have specialized training in their respective fields.

CLARA: Stunning! Speaking of the GAMA staff, rumors surrounding the hiring of doctors Pavel Frydel and Akane Akenawa have made headlines, with claims that they supposedly transplanted a liver infected with EHV, leading to the unfortunate demise of the patient shortly after. Such allegations might raise questions about the hospital's staff selection process and adherence to medical guidelines and ethical standards. Do you have any comment on these accusations, Ljudmila?

LJUDMILA: Er- well, Clara, the management of GAMA Hospital has vehemently denied all allegations of unethical practices and maintains that they uphold the highest standards of care for all patients. They state that they conduct thorough background checks on all staff members, including doctors, and that any individuals found to be involved in unethical practices are immediately removed from their position. The hospital has a strict code of ethics that all staff must adhere to, and any violations are taken very seriously. In response to the specific claims about the transplant procedure, GAMA states that they are investigating the matter in cooperation with the relevant authorities.

CLARA: Wonderful! I'm afraid that's all we have time for at the moment- lovely chatting with you again, Ljudmila!

@therealharrywatson @artofdeductionbysholmes @johnhwatsonblog

[techmezine2019]

TechMeZine: Medical Technology and Electronics Component Innovations

For both industry professionals and tech enthusiasts, being current with the newest developments in Electronics Components and the Latest Medical Technology News is absolutely vital in the always changing terrain of technology. Emphasizing their influence on many sectors and the possibility for future growth, this paper covers the most recent innovations in these disciplines.

Modern Electronics Component Design

 Efficiency and Minitization

Particularly in shrinking and efficiency, the sector of electronics components is seeing notable developments. Compact and effective devices are being created thanks in part to smaller, more powerful components. Faster processors and more efficient power management solutions resulting from semiconductor technological innovations These developments improve the functionality and performance of portable and wearable electronics, therefore facilitating their growth.

 Ecologically friendly electronics

In the manufacturing of Electronics Components sustainability is starting to take front stage. Manufacturers are using environmentally friendly materials and techniques more and more to lessen the effects of their electrical products. Given the rising demand for electronic goods, this change toward sustainability is absolutely necessary. Growing traction are initiatives to recycle electronic waste and create biodegradable components, therefore underscoring the industry's environmental conscience.

Medical Technology Innovations

Creative Medical Tools

The Latest Medical Technology News notes an explosion of creative medical tools changing patient treatment. Among the several ways technology is transforming the medical profession are advanced imaging systems, wearable health monitors, and AI-powered diagnostic instruments. Faster, more precise disease diagnosis made possible by these devices is helping patients and healthcare professionals obtain real-time health data, therefore enhancing general healthcare results.

 Remote Care and telemedicine

Particularly in recent years, telemedicine has grown to be an indispensable part of modern healthcare. The Latest Medical Technology News shows how telemedicine systems improving access to healthcare are developing. Particularly helpful in rural and underprivileged areas, virtual consultations let patients obtain treatment and guidance without leaving their homes. Along with increasing access to healthcare, this technology is simplifying and expediating processes.

Understanding the developments reshining our planet requires keeping updated about the newest trends in Electronics Components and the Latest Medical Technology News. By means of developments in miniaturization, sustainability, and connection, the electronics sector is advancing and generating more flexible and efficient gadgets. Modern gadgets, telemedicine, and tailored therapies are revolutionizing the medical industry and thereby enhancing patient care and healthcare delivery.

[reasonsforhope]

"Global life expectancy is forecasted to increase from 73.6 years of age in 2022 to 78.1 years of age in 2050 (a 4.5-year increase).

Life expectancy increases are projected to be greater in countries with lower life expectancies, reducing global disparities.

There will be a continued shift in disease burden from communicable, maternal, neonatal, and nutritional diseases to non-communicable diseases (NCDs).

The latest findings from the Global Burden of Disease Study (GBD) 2021, published today in The Lancet [May 17, 2024], forecast that global life expectancy will increase by 4.9 years in males and 4.2 years in females between 2022 and 2050. 

Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nutritional diseases (CMNNs)...

Global life expectancy is forecasted to increase from 73.6 years of age in 2022 to 78.1 years of age in 2050 (a 4.5-year increase). Global healthy life expectancy (HALE) – the average number of years a person can expect to live in good health – will increase from 64.8 years in 2022 to 67.4 years in 2050 (a 2.6-year increase). 

[Note: I cut out significant chunks of this article because they're being really shitty about "disability-adjusted life years," where they explicitly say that years lived as a disabled person don't count/don't count as much. Fuck that! Our lives are worth living!!!! Sincerely, your local disabled blogger.]

“In addition to an increase in life expectancy overall, we have found that the disparity in life expectancy across geographies will lessen,” said Dr. Chris Murray, Chair of Health Metrics Sciences at the University of Washington and Director of the Institute for Health Metrics and Evaluation (IHME). “This is an indicator that while health inequalities between the highest- and lowest-income regions will remain, the gaps are shrinking, with the biggest increases anticipated in sub-Saharan Africa.” ...

The Global Burden of Disease Study (GBD) is the largest and most comprehensive effort to quantify health loss across places and over time. It draws on the work of nearly 12,000 collaborators across more than 160 countries and territories. GBD 2021 – the newly published most recent round of GBD results – includes more than 607 billion estimates of 371 diseases and injuries and 88 risk factors in 204 countries and territories. The Institute for Health Metrics and Evaluation coordinates the study."

-via Institute for Health Metrics and Evaluation, May 17, 2024

--

Note: Obviously we need to make these gaps/disparities close completely!!! And it's also really good to see that we're on the right track.

I genuinely believe that the medical revolution that has just started this decade, along with the huge increase and revolution in communication technology, will make improvements in health and life expectancy come even faster than forecasted. Especially in low-income and low-life-expectancy countries

[therealdisneyfan2319]

The Spider and The Witch Chapter 1: The Experiment and The Flu

Summary: Peter Parker and Y/N L/N are junior biochem majors at Empire State College.  Peter needs a volunteer for his research project, and a series of events leads Y/N to come down with the flu...or does he?

Pairing: Wanda Maximoff x Male Reader

Warnings: Language, blood, needles, description of medical procedures

Word Count: 3.6K

Series Masterlist | Masterlist

“I don’t know how I managed to let you talk me into going to the lab with you this early.”  You stretched your arms out as you yawned, keeping your arm just so to keep your coffee upright.

“Dude.  It’s 10 am,” Peter chuckled.

“These good looks don’t just happen, man.  I need a full nine hours.”

“Maybe if you went to bed before 3 am-” “Now wait a minute.  You’re lecturing me about going to bed early when you used to pull all-nighters slinging webs around Queens?”

“Shut up!” He swatted your arm before you had the chance to pull away.  “At least I was doing something productive with my life, not playing Pokemon-” “Completing the Pokedex is extremely productive.  Now it might not be the same kind of productive as extracting the Spidey mutation from your genome sequence, but categorizing all the Pokemon from the Galar region is an important, time-consuming task.”

Peter rolled his eyes as he rolled down the sidewalk next to you.  You chuckled, taking a sip of your coffee as you shook your head.  This sort of banter was typical of your friendship.  Peter was one of your closest friends and easy to joke with, but you also worked well together.  It didn’t hurt that you were both biochem majors and had the same sort of scientific mind.  Since you met in world civ last fall the two of you had been as thick as thieves.  It didn’t matter that he was three years older than you, a grade above you, or that he used to be Spider-Man.  Finding out that the guy in the Stark tech wheelchair who loved Led Zeppelin and Star Wars was once the friendly neighborhood superhero was not what you expected when you went over to his dorm to hang out for the first time.  Peter was used to people freaking out when they found out and was thrilled when you shrugged it off.  

“So what exactly are we doing today?” you asked.  You had volunteered to help him out with a research project he was working on.  He hadn’t told you much about it, only that it was being funded by Tony Stark and dealt with genome sequencing. 

“Nothing too crazy.  I need to take samples of your blood.  I’ll use those as test subjects against my blood.  That’ll be the control sample.”  He punched in a sequence on the keypad on the arm of his chair.  Tank tracks dropped down from the bottom of the seat as the chair began to climb the stairs to the science building.  

“You know how to take blood?” you asked, holding the door open for him as he wheeled into the building.

“Yeah, well…yeah.  I mean Sam taught me how to start an IV and drawing blood is the same principle, right?  You gotta find the vein.”

“Oh my god I’m gonna die,” you mumbled as you turned down the hall toward the lab Peter worked out of.  It was one of the newest labs on campus.  Tony Stark had donated a sizable amount of money toward the Empire State College science and research division with the provision that all the money go toward funding better facilities for students.  The new building had just opened at the beginning of the semester.  Peter was more than excited to have a space stocked with the latest Stark technology to work on his newest endeavor.  It was more convenient than trying to head upstate to the Avengers Compound a few times a week.

“I won’t let you bleed out on me, man.  Worst comes to worst we’ll just throw some webs on it and send you to New York Pres.”

“Is that supposed to make me feel better about all of this?  Because it’s totally not.”  You hated needles.  You hated doctors.  The thought of someone who was decidedly NOT a medical professional fishing around your elbow for a vein made your stomach flip flop.  Maybe a large coffee wasn’t the best idea for breakfast…

The bright fluorescent lights in the lab snapped on as you opened the door.  They seemed unnecessary as sunlight flooded the windows that took up the entirety of the easternmost wall.  The overhead haze added to the sterile feel of the room: the latest in Stark Technology, ranging from microscopes and test tubes to autoclaves and fabricators, shone brightly against the lights.  It was nerd heaven, stuffed to the brim with everything anyone could ever need for any experiment they could dream of.  You threw your backpack on a lab table adjacent to where Peter was setting up his laptop.  Once you were done helping him out, you figured you’d swing by the library to start cracking on the paper for your art history course.

“So I already took my own samples earlier this week,” he explained. “I’m storing them in the fridge over there.  Mind grabbing them for me?” He motioned with his head to the mini fridge that sat next to the sink.  You walked over to the fridge, seeing a rack of blood vials sitting on the bottom shelf amongst the Petri dishes of spores and sole can of Coke.  “Don’t drop it,” he cautioned as grabbed a ziploc baggie of medical supplies out of his bag.

“Whoop.”  You fake tripped, stumbling around and swinging the tray to and fro aimlessly.  He shot you a somewhat serious glare.  You returned a toothy grin.  

“Dude if you drop that-”

“Relax, Pete.  I’ve got steady hands.”  You placed the tray on the table in front of him with the grace of a swan.  “See?” You raised your hands up defensively.  “Steady hands.  I should be a goddamn surgeon.”

“Ah yes, Dr. Y/N L/N, the surgeon who hates blood.”  He dumped the contents onto the table.  Out fell some rubber gloves, a rubber tourniquet, needles, tubes, alcohol wipes, and cotton balls.  You gulped at the sight of the paraphernalia.  “So why don’t you just sit there and roll up your sleeve so we can do this.”

“Are you sure you can’t just, like, prick my finger?”  Plopping onto the stool you rolled up the sleeve of flannel.  

“Do you want to sit here and fill up these tubes one drop at a time?” Peter asked from the sink.  The tray of tubes, empty ones and ones full of his blood, sat next to him as he washed his hands.

“Good point,” you muttered.  It felt like you were chewing on the flannel from your shirt.

“Just relax, I did it on myself the other day and I turned out just fine.”  There was a slight waver in your friend’s voice as he spoke.  Try as he might to hide it, Peter was nervous, too.  He snapped on the baby blue gloves.  You turned your head away, refusing to look until he was done.  “Can you just make a fist for-good okay, yup, I see the vein.”  The sudden coolness of the alcohol against your skin made you shiver, but you refused to look.  Even as you felt the slight prick of the needle against your skin you kept your eyes firmly shut.  “Told you I wouldn’t let you bleed out,” he chuckled, replacing the now full vial with an empty one.

“How many vials do you need?”  You strained your neck as you tried to look as far away as you could from the scene unfolding in front of you.

“I don’t know, I did six of my own.  That should be enough,” Peter shrugged.  

Six vials of blood?  Why did you even decide to do this in the first place?  You could’ve been back in your dorm in the comfort of your bed, sleeping the morning away, instead of having your blood forcibly removed from your body.  Peter definitely owed you big time.  

He removed the tube from your arm, handing you a cotton ball to stop the bleeding.  “That should be it.  Mind putting those back in the fridge for me?”  

The second your feet hit the floor your knees wobbled.  It was probably psychosomatic, but the sight of all your blood sitting inches outside where it should be made you the slightest bit queasy.  “Yeah, no problem.”  You shook your head quickly.  There was no way you were going to let yourself puke or, even worse, drop the vials and have to do it all over again.  

It took all your effort not to look down at the plastic tray in your hands.  You concentrated all your effort on staring down the refrigerator.  That ultimately meant neglecting your untied shoelace.  Before you realized what was happening you found yourself tripping over your feet.  While you managed to not lose your balance completely, the sudden jolt sent two of the vials crashing to the floor.

“Shit,” you mumbled as you set the tray on the floor.  There were shards of glass and blood splattered across the marble tile.  You quickly glanced over your shoulder, hoping Peter hadn’t seen your mistake.  Much to your relief he was engrossed in his notebook.  That bought you some time to quickly clean up the mess.  You looked around for a roll of paper towels, spotting the roll next to the sink and tearing off a few sheets.  The crimson puddles looked like they’d be easy enough to clean up.  Not thinking too much about it, you knelt down and started blotting at the spill.  A sudden stab caused you to recoil from the ground in pain.  As you examined your hand, you noticed a small scratch on the pad of your thumb.  

“You good?” Peter’s voice broke you away from staring at your hand.

“Yeah.  Dropped one of the vials and cut myself.  I’m good.”

“Was it one of mine or yours?”

“Uhh, mine.”  Truth be told you had no idea if it was yours or his.  There was no way to know which vial was which.  Peter knew.  He probably had it marked down in his laptop or something.  But you remembered that his vials were facing you when you pulled them out of the fridge.  That meant yours were away from you and there was an empty spot there.  Yeah, it’s mine.  “You need me for anything else?”

“Nah, you’re good,” Peter focused intensely on his laptop, typing away as you finished cleaning up your mess and putting the samples away.  “Are we still on for dinner tonight?  Ned’s dying to try out that new Thai place on Watts Street.”

“Yeah, shoot me a text.  I’m headed to the library for a bit.”  You slung your backpack over your shoulder as you headed for the door.  “See you.”

“Thanks again, Y/N.”

******

You spent the rest of the day in the library researching and typing and revising your paper.  The minutes ticked by as you lost yourself in the endless barrage of Western paintings you thought looked all too similar.  Yet as the day passed you found yourself feeling strange.  At first you thought you had been studying too long.  The words on your laptop screen seemed fuzzy and you found yourself re-reading the same paragraph on Donatello about a dozen times before anything seemed to click.  Then the library seemed to drop ten degrees before abruptly shooting up another twenty.  Sweat on the back of your neck ran down your shirt and chilled you as fast as it cooled you off.  The lights were suddenly too bright and even the silence was too loud.  

Shit, you thought to yourself as your felt heat radiating off your forehead.  It was probably the flu.  It had been making the rounds through campus for the better part of a month, so you weren’t completely surprised.  Closing your laptop and shoving your books in your bag, you texted Peter as you left the library:

Got the flu.  You and Ned go without me.  I’m gonna go to bed.

The walk back to your apartment wasn’t long, but it was a near-impossible task in your ever-worsening condition.  Every step felt like you were trudging through molasses.  Your legs were as heavy as cement and you prayed you wouldn’t trip because you weren’t sure you’d be able to get up again.  Tears clouded your vision.  Rubbing your eyes didn’t help.  The only thing on your mind was downing half a bottle of Nyquil and passing out as soon as you got back to your room.  

Much to your relief you walked into an empty apartment.  Peter and Ned must’ve already left for dinner.  You kicked your shoes off and dropped your bag at the front door.  There was no doubt in your mind that this was the flu: you felt like absolute garbage as you shuffled to your bedroom.  As you flopped on the bed, clothes and all, your body felt like it was made of lead.  Bone-crushing fatigue consumed you as you shivered on top of your bedspread.  You prayed that you’d be able to get a little bit of sleep to help dull the pain.

When you woke the following morning, you were surprised to find that you didn’t feel sick at all.  In fact, you felt better than you had in a long time.  There wasn’t any evidence that you felt so poorly only a few hours ago.  You swung your legs around to the side of the bed and stared at the floor as you thought about what you were going to do all day, but when you tried to stand up something was off.  As you stretched your arms above your head, you felt something engulf you: it was your blanket.  It was stuck to your hands.  

Did I spill Nyquil on my hands? you wondered as you tugged at the fuzzy fabric.  No, I didn’t take any Nyquil last night.

It took a considerable amount of effort to tear just one of your hands away only for it to stick on the wall as you balanced against it for support.  Paint flaked away as you ripped your hand away.  At that point you weren’t sure if you were still asleep or not.  Squeezing your eyes shut, you reopened them to find flakes of drywall still attached to your fingers.  What the hell?  You shook your hands, trying to free yourself of the debris, but as you flicked your wrist downward, you heard a loud thwack.  The sticky white residue covered Marty McFly’s face on the Back to the Future poster that hung next to your bed.  That same white residue balled up on the inside of your wrist.  When you tried to pull it off, a long spindly web came with it.

Oh fuck.

The implications of what just happened were huge to say the least.  The vial you broke yesterday wasn’t yours: it was Peter’s.  His blood contaminated yours when you cut yourself and now you had…spidey powers?  It couldn’t be.  This all had to be some sort of nightmare.  You were just a normal guy trying to make it through college relatively unscathed.  Sure, your roommate was an Avenger and that was a little weird, but other than that your experience was pretty normal.  You had no interest in having superpowers or saving the world whatsoever.  

“Everything okay in there, man?” Peter asked as he rapped on your door.  It momentarily snapped you out of your panic.

“Uhh yeah, yeah.  I’m good,” you hollered through the door, still looking at the web in your hand.  

“You sure?”

“Yeah.  I’m okay.  Just, uhh, knocked my blankets off the bed.”  You wiped the web up with a tissue, praying that it wouldn’t stick to your hand, too.  It didn’t, much to your relief.  

“How are you feeling?” he called as you started taking off your clothes from the day before.  A long shower would help you figure out what your next move was.  

“Good.  Great actually.  I feel fine,” you responded, throwing your dirty t-shirt on the ground.  “How was dinner?” “It totally sucked, man.  You didn’t miss much,” Ned’s voice was faint as he yelled from the kitchen.  

“Bummer.  I told you that you should’ve done Indian instead.”

“Well hey if you’re feeling better why don’t we go for lunch?” Your stomach grumbled at the thought, but images of getting stuck to the subway pole loomed in your mind.  “Yeah, sure,” you responded absentmindedly while kicking your pants off and grabbing a clean pair of sweats off your bed.  

Wearing nothing but your boxers, you opened the door fully intending to go straight to the bathroom.  The second Peter and Ned saw you their jaws dropped.

“Dude!” Peter exclaimed. 

“Wha-?”  

“Woah!  Y/N, when did you get ripped?” Ned asked.  You were thoroughly confused.  None of your hobbies included going to the gym or working out.  What were they talking about?  The lights came on in the bathroom and as your eyes adjusted to the brightness you were shocked.  It was like someone took a  chisel to your body overnight.  There were muscles in places you didn't know there could be muscles.  The reflection in the mirror showed you defined pecs, swollen biceps, and the faintest outline of a six pack.

“What the hell?” you mumbled in disbelief.  Your fingers traced over your chest, taking in the new body you’d inadvertently fallen into.  It was a surreal experience seeing an unfamiliar body in the mirror.  It was almost like you were watching someone else live your life while you watched from outside yourself.

“Are you sure you’re alright, Y/N?” Peter asked as he wheeled himself in front of the bathroom door.

“Yeah.  I’ve just got spidey powers now.”  It didn’t even feel like you were the one saying those words.  Haze clouded your periphery, forcing you to focus on the newness of your body.  It was an out-of-body experience in every way.  There was no way to really process the profundity of the situation.  

“You WHAT?”

Time stopped.  Everything stopped.  Peter’s face contorted with dozens of emotions in the blink of an eye.  Glass shattered on the kitchen floor as Ned’s glass slipped out of his hand.  

“Umm, yeah I guess.  I’m starting to think that was your blood that I cleaned up yesterday.”  You half expected Peter to be furious at the truth, but the beaming grin on his face told you otherwise.

“It worked!  Holy shit it WORKED!”  He spun his chair around excitedly, whooping all the while.  “Mr. Stark, oh man, he’s gonna be so excited!  He’ll want to meet you.  Man, now he doesn’t even need to look for someone to be the next Spider-Man because…oh this is great, I can teach you everything!  That way you’ll be WAY ahead of where he thinks you should be and he’ll let you onto the team fas-”

“The next Spider-Man?”

“I mean yeah, Mr. Stark will definitely want to talk to you about it,” Peter replied.

“Dude, I’d kill to be Spider-Man!” Ned added, sweeping up what remained of his glass.

“No way, absolutely not,” you groused as you stormed out of the bathroom.  “No offense, Pete, but I don’t want to be an Avenger.”

“You don’t have to make a decision now.  I don’t even know if he’ll ask.  I mean he probably will but that doesn’t mean anything.  He might just want you to come in to do, like, more testing or something.”  Peter gingerly walked back his excitement.  The prospect of training the next Spider-Man brought a sense of optimism back into his life that had long been forgotten.  Losing his identity as the local neighborhood web slinger stripped away a core part of his identity: Peter Parker and Spider-Man were one in the same.  Sure, he still used his powers and webs when he could, but it wasn’t the same.  Tony had offered to make him an exosuit after the accident, but he knew that he couldn’t do it anymore.  One close brush with death was more than enough for him.

“Look,” you sighed, “I’m not you.  I don’t want to go out and swing through Manhattan and stop burglars or fight weird lizard things.  I just want to be a normal guy doing normal guy things with my normal guy friends if I can even call the two of you normal.”  Peter chuckled half-heartedly.

“Wait, can you stick to the ceiling?” Ned suddenly asked.  You sighed again, shaking your head as you extended your arm up and jumped: you stuck.  “Woah!  That’s sweet!”

“Yeah, it is kinda cool I guess,” you chuckled as you watched your fingertips completely suspend your dead weight from the ceiling.  Getting used to your new body was a curious sensation.  Everything felt sharper.  Colors were brighter and bolder.  You saw incredibly small movements even from the corners of your eye.  Your body felt stronger and faster and more agile.  It was strange, spending your entire life as a regular human being and then waking up one day twenty years later with these weird spidery feelings tingling inside you.  

“Do you want one of my web shooters?” Peter asked as you dropped down.

“Web shooters?”

“Yeah,” Peter replied questioningly as he raised an eyebrow.  “You don’t think I can actually make webs, do you?”

You responded by mimicking the hand gesture Peter frequently showed you, flicking your wrist downward as a raveled strand of webs flew out of your wrist.  Peter ducked his head out of the way in the knick of time while Ned’s jaw dropped in amazement.  

“Didn’t see that coming, did you?”

[mariacallous]

On a recent Thursday afternoon, researchers Lanuza Faccioli and Zhiping Hu wheeled an inconspicuous black and white plastic cooler from an operating room at a hospital in downtown Pittsburgh. Inside was a badly scarred liver, just removed from a 47-year-old man undergoing a transplant to receive a new one from a donor.

But what if patients could avoid that fate? Faccioli and Hu are part of a University of Pittsburgh team led by Alejandro Soto-Gutiérrez attempting to revive badly damaged livers like these—as well as kidneys, hearts, and lungs. Using messenger RNA, the same technology used in some of the Covid-19 vaccines, they’re aiming to reprogram terminally ill organs to be fit and functioning again. With donor livers in short supply, they think mRNA could one day provide an alternative to transplants. The team plans to begin a clinical trial next year to test the idea in people with end-stage liver disease.

Alcohol use, hepatitis infection, and a buildup of fat in the liver can cause scarring over time. When there’s too much damage, the liver starts to fail. “Right now, if you get end-stage liver disease, it’s irreversible,” Soto-Gutiérrez says. “Well, we found that is not true. It is reversible.”

Soto-Gutiérrez and his team have been experimenting on rats and organs taken from people undergoing transplants at the University of Pittsburgh Medical Center, one of the busiest transplant centers in the US. To help design the mRNA and figure out how to deliver it to the human liver, they’ve partnered with Drew Weissman, a physician and immunologist at the University of Pennsylvania who won the 2023 Nobel Prize in Physiology or Medicine for his pioneering work on mRNA. Together, Soto-Gutiérrez and Weissman lead the Center for Transcriptional Medicine, launched in April with the goal of bringing these medicines to patients.

On the day I visited, I followed Faccioli and Hu through a maze of hallways until they deposited the freshly explanted liver at a pathology lab, where a team of scientists was anticipating the special delivery. After infusing the liver with an experimental mRNA therapy, they placed the organ in an oxygenated bath meant to maintain its function for several days.

A healthy liver is spongy and reddish-brown in color with a smooth appearance. But when the surgeons took this one out of the cooler, it was hard, marbled, and covered in bumps—evidence of cirrhosis, a type of end-stage liver disease. Over time, the man’s healthy liver cells had been replaced by scar tissue, and eventually, his liver stopped working. His only option was to get a new one.

Livers are the second most in-demand organ. In 2023, a record 10,660 liver transplants were performed in the US, driven in part by a steadily growing number of living donors. In a living liver transplant, a piece is taken from a healthy person’s liver and transplanted into a recipient. But even with this uptick in transplants, not everyone who needs a new liver receives one. Patients may have other health problems that disqualify them from a transplant, and others may die while waiting for one. In 2022, the latest year for which data is available, the Centers for Disease Control and Prevention recorded nearly 55,000 deaths due to chronic liver disease.

Living donor transplants are possible because of the liver’s unique capacity to regenerate itself—more so than any other organ in the body. In a healthy person, the liver can regrow to its normal size even after up to 90 percent of it has been removed. But disease and lifestyle factors can cause permanent damage, rendering the liver unable to repair itself.

When Soto-Gutiérrez was studying medicine at the University of Guadalajara in Mexico, his uncle died of liver disease. From then on, he became dedicated to finding a treatment for patients like his uncle. In the early years of his medical career, he noticed that some patients with scarred livers were bound to a hospital bed waiting for a transplant, while other people with cirrhosis were walking around, seemingly living normal lives. He figured there must be cellular differences in these livers.

He teamed up with UPMC transplant surgeon Ira Fox to look for transcription factors—master regulators that can dial up or down the expression of groups of genes—that can potentially reprogram injured organs. Genes rely on transcription factors to perform many essential functions in organs. Together, Soto-Gutiérrez and Fox have analyzed more than 400 failing livers donated by transplant patients. When they compared them with dozens of normal donated livers that acted as controls, they identified eight transcription factors essential for organ development and function.

They zeroed in on one in particular, HNF4 alpha, that seems to act like a main control panel, regulating much of the gene expression in liver cells. In healthy liver cells, levels of HNF4 alpha were turned up, and so were other proteins it controls. But in the cirrhotic livers they examined, HNF4 alpha was almost nonexistent.

The team needed a way to get the transcription factor into liver cells, so they turned to mRNA technology. Used in some of the Covid-19 vaccines, mRNA is a molecule that carries instructions for making proteins, including transcription factors. In the Covid vaccines, the mRNA codes for a part of the virus known as the spike protein. When injected into a person’s arm, the mRNA enters cells and kicks off the protein-making process. The body recognizes these spike proteins as foreign and generates antibodies and other defenders against it.

The Pitt team is using mRNA instead to essentially turn back time in injured organs. “What we’re proposing to do with mRNA is use it to deliver proteins that have the capacity to repair those damaged liver cells,” Weissman says. “Our hope is that we can treat end-stage liver disease and turn the livers around, maybe forever, or at least until patients can get a transplanted organ liver.” Instead of delivering instructions for a foreign protein to generate an immune response, they’re delivering the genetic code for producing a transcription factor—HNF4 alpha.

In a paper published in 2021, the approach revived human liver cells in lab dishes. The researchers have since tested the mRNA therapy in rats with cirrhosis and liver failure. They treated a group of rats every three days for three weeks while a second group served as a control. The animals that were receiving the injection of HNF4 alpha started being more active. The untreated rats continued to decline and eventually died, the expected result at their stage of disease. Some of the treated rats were still living six weeks after receiving the mRNA medicine. Those results have not yet been published in a peer reviewed journal.

The team is also testing the mRNA infusions in human livers removed from patients undergoing transplants—the process I got to observe. Unlike live rats, explanted human livers can’t be observed for weeks on end. Livers have to be retrieved quickly and infused with the mRNA treatment soon after they’re removed from the body. They stay fresh for just four days or so in a preservation fluid. Six hours after the mRNA infusion, levels of HNF4 alpha start going up and last for two to three days. When HNF4 alpha peaks, other essential liver proteins, such as albumin, start to increase as well. That’s important, Soto-Gutiérrez says, because maintaining those protein levels could mean the difference between a patient needing a transplant or not.

Ideally, Soto-Gutiérrez says the mRNA therapy would be something patients could get once a week or every other week in an outpatient facility and go back home. But initially, they’ll need to test the experimental treatment in very sick patients, likely ones that are hospitalized, to make sure it’s safe. The team is gathering data from the rat and human liver experiments to submit a clinical trial application to the Food and Drug Administration in the coming months.

While livers are the first target, Fox thinks other injured organs may be amenable to this approach. “We’ve been wondering whether the same process might be taking place in other organs,” he says. Currently, the team is searching for similar transcription factors in lungs with chronic obstructive pulmonary disease and kidneys with chronic kidney disease.

Josh Levitsky, a liver transplant specialist at Northwestern University who isn’t involved in the work, says new treatments for chronic liver disease are sorely needed. Current therapies can help slow down scar tissue buildup and ease symptoms but don’t address the underlying disease. “The concept of reprogramming and being able to reverse liver failure could be really game changing if it were to pan out in clinical studies,” he says.

But lots of questions remain. How much damage could be reversed? Would patients need to be on the therapy indefinitely? Or would their livers rebound enough to go off it? Could a liver ever be restored back to normal?

“It certainly has a lot of promise,” Levitsky says, “but the clinical development is going to take a long time.”

[blueiscoool]

33 Greco-Roman Family Tombs Found in Aswan, Egypt

An Egyptian-Italian archaeological mission has uncovered 33 family tombs from the Greco-Roman period near the Aga Khan Mausoleum in Aswan, Egypt.

The joint mission, led by Dr. Mohamed Ismail Khaled, Secretary-General of the Supreme Council of Antiquities, and Professor Patrizia Piacentini from the University of Milan, made the announcement earlier this month. The tombs, discovered west of Aswan’s Nile, date back to the Late Period and the Greco-Roman era, spanning from the sixth century BCE to the third century CE.

The Aga Khan Mausoleum, the resting place of Aga Khan III, Sir Sultan Muhammed Shah, who passed away in 1957, now sits above a necropolis with over 400 tombs. Dr. Khaled noted that it adds a new historical dimension to the Aga Khan area. The tombs vary in architectural style, with some featuring arched entrances and open courtyards made from mudbrick, while others are directly carved into the mountain rock. This diversity reflects the social stratification of the period.

Among the notable finds are mummified remains and funerary objects, including clay figures, sacrificial tables, ceramics, and painted cartonnages. An intriguing discovery within a stone coffin revealed the mummified remains of an adult and a child, likely adhered together by embalming fluids. Further analysis is planned to understand their relationship.

Anthropological and radiological studies have provided insights into the health conditions of buried individuals. Dr. Patricia Piachenti from the University of Milan noted that 30% to 40% of the deceased were infants, children, or adolescents. This high mortality rate among the young offers clues about prevalent diseases during that period. The remains of several adult women showed signs of pelvic bone trauma, suggesting childbirth complications or other medical conditions. Other mummies exhibited evidence of anemia, malnutrition, chest diseases, tuberculosis, and osteoporosis.

“Initial studies reveal that many individuals suffered from infectious diseases and bone disorders,” said Dr. Piacentini. “Some adult females showed signs of medical interventions such as amputations and bone trauma, indicating that ancient Aswan had developed some medical practices.”

Dr. Ayman Ashmawy, Head of the Egyptian Antiquities Sector, said that the lower parts of the necropolis were likely reserved for the middle-class residents of Aswan Island, including physicians, artisans, merchants, and storekeepers. The upper parts of the necropolis, however, appear to have been reserved for the wealthier upper class. This social stratification is reflected in the differing architectural styles and the types of artifacts found within the tombs.

The discoveries also include remains of colored cartonnage, clay and stone figurines, wooden coffins, and offering tables. The tombs’ architectural complexity reflects the advanced skills of the ancient craftsmen who overcame the challenges of digging into rock and constructing low-ceilinged funerary rooms and galleries.

The mission has employed the latest technology, including X-ray and CT scans, to analyze the mummies and artifacts. These technologies have allowed researchers to create three-dimensional reconstructions of the mummies and identify items such as bracelets found on some individuals.

By Dario Radley.

[covid-safer-hotties]

We can do better for young people with long covid - Published July 25, 2024

We need greater awareness, resources, and rehabilitation for children and adolescents with long covid

Research and resources to support children and adolescents living with post covid-19 condition (long covid) are sparse. Difficulties with diagnosis, non-specific symptoms, and a lack of awareness are just some of the reasons for this, and they contribute to the stigmatisation of this relatively new condition. Greater support, treatments, and resources are needed for young people living with long covid.

Global prevalence estimates of long covid in children vary widely depending on cohort, methodology, and definition, with reported rates of 1.6-70%.3 Obtaining a diagnosis can take time as investigations are needed to eliminate other possible disease cause, and symptoms can be broad and fluctuate or relapse over time. Symptoms of the condition include fatigue, exertion intolerance, mood changes, sleep disorders, headache, pain, and change in respiratory function and can affect everyday functioning, such as eating habits, activities of daily living, physical activity, behaviour, academic performance and school attendance, and social interactions.

The nature of the symptoms, a lack of professional awareness, and absence of a definitive diagnostic test mean that stigmatisation is common. Young people with long covid frequently feel embarrassed about having the condition and its physical limitations, and that people behaved differently towards them because of misinformed notions that they might be exaggerating or that long covid is not a real disease. It has been suggested that stigma drives people away from health services, contributes to psychological distress, and compromises long term physical outcomes.

The latest data from the UK Office for National Statistics estimated that more than 100 000 children and young people aged 3-17 living in England and Scotland were experiencing self-reported long covid in the month period ending 7 March 2024. More than 20 000 of these children and adolescents reported that their ability to undertake daily activities had been limited “a lot.”

Appropriate medical screening, rehabilitation, and assistive technologies can support those living with long covid by improving physical, mental, cognitive, and social functioning to perform essential everyday tasks such as self-care, communication, or mobility. Evidence based resources from the World Health Organization, produced with the long covid kids’ youth advisory panel, are available on this topic, and provide guidance on subjects such as pacing activity, managing breathlessness, and returning to education. Rehabilitation and assistive technologies can help improve participation in family life, education, and employment.

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