#Lab Equipment Validation San Francisco
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What Are the Risks for the Laboratory Instrument Validation Process?
Medical processes require precision, confidence, and absolute control. There is no room for mistake or ignorance. Therefore, absolute assurance that everything is in order is vital in medical procedures, chemical procedures, laboratory tests, or laboratory instruments.
But it does not mean that there is no risk involved. On the contrary, there is always an inherent risk involved with laboratory instruments and equipment. This is because these laboratory instruments are used for various processes, and each process is significant, no matter how small. Thus, all laboratory instruments are subject to validation.
Only a qualified and professional team is eligible for laboratory equipment validation in San Francisco. Thus, you need Biotechnical Services Inc. on-board to perform timely validation.
What Is Laboratory Equipment Validation?
Laboratory equipment validation is performing various quality checks and ensuring that the installed equipment conforms to the quality standards and is suitable for the desired operations.
From the initial stage of leaving the manufacturer’s place to installation in the laboratory, various instances might affect the installation of lab equipment and instruments.
The Inherent Risk for Equipment Validation
Risk is the combination of the probability of an unwanted event harming the instrument and the extent of that harm. There are different sources of harm, but their extent is different, and it is the job of the validation team to ascertain the potential harms and save instruments from them.
The risk to laboratory instrument validation comes from different areas, such as the staff, the environment, instrument handling, etc., which will be discussed in length in this blog.
Risks During Laboratory Equipment Validation
Biotechnical Services Inc. has an experienced team for laboratory equipment validation in San Francisco, which considers the below risk factors during laboratory instrument validation.
Point of Validation
There are different points in time when laboratory instruments are validated. The first point is the manufacturer’s place. Every instrument undergoes validation after its manufacturing. It is called commissioning, which ensures that an equipment’s design meets the authorized standard.
Though every piece of equipment is designed per the confirmed standards, an equipment’s design may differ. As a result, it poses a great risk to the laboratory once it has been put to use and also poses severe non-compliance risks. Thus, every manufacturer must ensure that each piece of equipment is validated after manufacturing, so problems can be detected in the factory for repairs.
Installation Environment
Every piece of equipment comes with a manual specifying clear installation instructions and a suitable environment in which the equipment will perform the best and offer the correct results. The installation team must adhere to these instructions.
Though, there is also an inherent risk that the equipment suffered any damage during the transit. The first job of the installation team is to ensure that equipment is in good condition.
The laboratories are required to create a suitable environment for the equipment, for example, a flat surface, the right temperature, humidity, availability of required electrical connection, and other accessories which assist in proper functioning.
Most pieces of equipment fail due to non-maintenance of environmental conditions. Therefore, during the installation and future validation, the validation team must ensure the environment is suitable.
Following the manufacturer’s instructions can also save money and time.
Irregular Calibration
Irregular equipment calibration is the most significant risk concerning laboratory equipment validation in San Francisco. Every piece of equipment faces wear and tear over time. The manner of usage and staff training is important in ensuring the equipment’s health. But timely calibration is most vital.
Calibration is the process of ensuring that the equipment offers accurate results. All instruments, such as weighing scales, centrifuges, etc., are subject to calibration. Therefore, the calibration laboratory must prepare a schedule for equipment calibration.
Usually, lab equipment and instruments are calibrated after installation, before undertaking an important project, on client’s demand, or before the equipment calibration period is over.
Every laboratory is required to have a calibration laboratory onboard which can ensure timely calibration; else, the instruments will offer inaccurate results, and the outcomes can be deadly. For example, a medicine can be weighed wrongly, a temperature for a chemical might be recorded inaccurately, and wrong quantities of chemicals can be mixed, which can be fatal to laboratory staff. The risk of equipment qualification is even higher.
How Biotechnical Services Inc. Can Help?
Biotechnical Services Inc. offers laboratory equipment validation services in San Diego, San Francisco, and Los Angeles. It has been doing so for the last 31 years and is known for its strict adherence to regulatory policies.
Our team of professionals has extensive experience, which confirms your staff and equipment’s safety. Timely validation is invaluable, and being in the field for decades, we understand it.
Contact us today for more information.
Original Source: https://www.biotechserv.com/what-are-the-risks-for-the-laboratory-instrument-validation-process/
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Hello! my name is Page [21+, PST/UTC-8] 🎔 I wanted to get something posted! First of all, hooray for opening! Secondly, I'd like to plot! Like that's sort of the main thing. I am totally willing to try and make Tumblr messages work if that's your preferred method of communication, but I'm definitely more responsive on Discord! If you want to plot, like this post and I'll hop on over to your DMs! I've got an embarrassing number of muses I'm bringing in and didn't want to make a thousand different intros to be totally honest, so I've got my first batch with some information below the read more, and I'll post for the second group over the next day or so! Click the banners to see their profiles if you want more info.🎔
Yebai moved to Korea when he was a child after his mother remarried. His mother is great, and his stepdad is a sweetheart, but nevertheless, as the leftover kid and with a pair of younger half-siblings, he has always felt like a moon in orbit, wanting nothing more than his feet on the ground. He's done well enough for himself, going to school for graphic design and digital art and getting a foot in the door in the industry, doing jobs here and there on top of doing the art for an indie games studio, but he's never stopped wanting more friends and more validation and a little more adventure.
Plotting Points: Yebai is a huge NewAve fan, with a Twitter account devoted to posting chibi comics and occasionally more fully-rendered fanart of his biases. Tweets at least once per month about the two fancalls he's had with his fave. Once collaborated with a fansite to design a plush doll of said member. School friends? Or school enemies. Coworkers? He loves to go out into public and sketch scenes and people. Frequents cafes and parks. Very outgoing.
Hyeji was very nearly an it girl, placing second on a popular idol survival show in 2016. A rigging scandal brought her two year-old group (and a planned franchise) to an end, and for a while, it seemed as though her career had fallen victim to his as well for a time. Her company debuted her as a soloist, but they were ill-equipped, and perhaps hesitant to promote her. She languished in lack-of-release limbo for a few years, picking up a few bad habits in her downtime during overly long hiatuses. She's sober now, if only barely, and has in the last year or so signed to Canvas Labs after her contract with her last company expired. As she puts together her debut album, she's also in the process of piecing together her identity. She's not sure that she knows who she is, if not a party girl.
Plotting Points: She's fairly well-known amongst a certain demographic of young people (especially women) in their 20s and international Kpop fans and does a lot of CFs and promotions even though her musical releases have been scarce, occupying a niche somewhere between Sunmi and Chungha and Somi. Canvas Labs employees and idols. She has crawled half of the clubs in Seoul by this point. Exes? Situationships that got a little complicated? Friendships that got messy? Maybe more than that, if there's chemistry?
Katrina lives with her grandmother in Seoul while she attends school, aiding the increasingly less-mobile woman with her chores. Originally from San Francisco, her mother is the charismatic pastor-president of a luxe, modern church, and her father is a plastic surgeon. Growing up, she's known nothing but strict rules governing femininity, womanhood, and the role she was to play in the world if she was to be saved. Korea confuses her. Here, a lot of those lessons ring true, and yet, freed from the covenant eyes of her parents and church community, her previously well-defined sense of self, and of the world, has begun to fray about the edges.
Plotting Points: Volunteers at animal shelters and community food-security orgs semi-regularly. People she's met at school? Someone who frequents the same thrift shops and tea shops she does? Has tried to attend several different churches in Korea and been weirded out by each one. Has an interest in musical theatre and is secretly obsessed with a couple of 40 year old musical actors. Has done some modeling for random little clothing brands.
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Why smartwatch-measured blood pressure still isn’t ‘ready for primetime’
New Post has been published on https://depression-md.com/why-smartwatch-measured-blood-pressure-still-isnt-ready-for-primetime/
Why smartwatch-measured blood pressure still isn’t ‘ready for primetime’
It’s been over two years since Samsung first announced that its Galaxy Watch would be able to measure people’s blood pressure. The feature is available in a number of countries, including South Korea, but not in the United States — the company is still awaiting Food and Drug Administration clearance. In the meantime, other smartwatch companies have started experimenting with blood pressure tech in a bid for monitors on their devices. Fitbit announced a study trialing a blood pressure monitor in April, and Apple is reportedly working on its own version, as well.
Adding a blood pressure monitor to smartwatches could arguably be more important for users’ cardiovascular health than the heart rate and rhythm monitors they have now, says says Ann Marie Navar, a cardiologist at the University of Texas Southwestern Medical Center. “Blood pressure measurement is something we need to do a lot more a lot of,” she says.
“We’re not ready for primetime yet”
But it’s still not clear how reliable smartwatch-measured blood pressure could be. Measuring blood pressure is much harder than tracking heart rate and rhythm, and getting it right is arguably even more important. “We’re not ready for primetime yet,” says Jordana Cohen, an assistant professor of medicine at the University of Pennsylvania who studies hypertension.
Squeeze-free methods
Having more ways to easily take blood pressure measurements at home could be a big benefit to people with hypertension (high blood pressure) or other concerns. Pressure measurements taken exclusively in a doctor’s office are often unreliable: some people have higher blood pressure in-office because they’re anxious about the visit, while other people have masked hypertension — high blood pressure at home, but normal blood pressure at the doctor. “We don’t pick it up unless we have people check their blood pressures at home,” Navar says.
There are plenty of at-home blood pressure cuffs that take the standard approach: a cuff gets strapped onto a patient’s upper arm. Inflating the cuff cuts off blood flow, and the device measures the pressure blood is putting on vessel walls when blood starts flowing again as the compression is released.
The Omron HeartGuide device has a built-in blood pressure cuff.
Photo by David Becker / Getty Images
Right now, there’s one wearable device cleared by the Food and Drug Administration to measure blood pressure: a device from medical equipment company Omron, which has an inflatable cuff inside the band that lets it take blood pressure measurements at the wrist using the traditional squeezing method. Unlike smartwatches that are hoping to add blood pressure to existing tech, Omron’s HeartGuide is extremely specialized. It’s even marketed as “a wearable blood pressure monitor in the innovative form of a wristwatch”
Smartwatch companies like Samsung and Fitbit are taking another approach. They are using light sensors on the smartwatches to calculate blood pressure. It’s a big challenge, says Wendy Mendes, a psychophysiologist at the University of California San Francisco who works with Samsung on its tool.
Samsung’s approach is based on a measure called pulse transit time, which is the time between the contraction of the heart and when the pulse arrives at a particular body part, like the wrist. It’s correlated with blood pressure. “The faster that pulse transit time is, the more the vessels are tightening — that’s what’s making the pulse travel faster,” Mendes says. Optical sensors also check if vessels are tightening or widening. An algorithm then uses those two bits of information, along with heart rate, to estimate blood pressure.
Fitbit is a few steps further back in the process — it doesn’t have any blood pressure features available but has a handful of studies underway looking at the relationship between the metrics already collected by its devices and blood pressure. They’re focusing on a measure called pulse arrival time. It’s similar to pulse transit time but measures the pulse at a slightly different time than Samsung does, says Eric Friedman, vice president of research at Fitbit.
A press image of Samsung’s Health Monitor Application with Blood Pressure Measurement.
Image: Samsung
There’s a limitation to both of these strategies: generally, they can only reliably measure relative blood pressure. Mendes could strap a watch on and find out if someone’s blood pressure was higher in the morning than it was when they went to sleep the previous night, but wouldn’t be able to tell what the raw number it started at was without benchmarking the device off of a standard blood pressure cuff. “Almost all of these sensors are going to be good at changes,” she says. “But to get the level, you have to calibrate it.” Samsung suggests users recalibrate the blood pressure monitor on their smartwatches every four weeks.
Apple’s blood pressure feature is still in development and has not been formally announced. It would reportedly just give people information on trends in their blood pressure — if it’s increasing or decreasing — rather than a raw measure, which requires the calibration step used by Samsung, according to The Wall Street Journal. That’s a more realistic approach, Cohen says, because the techniques used in smartwatches are much more capable of detecting relative changes in blood pressure.
“I don’t have the hubris to view it as something that’s coming out any day now.”
The sensors currently common in smartwatches probably won’t be able to measure blood pressure without calibration against an outside cuff, Mendes says. “I do think it’s possible, but I don’t think the technology is there yet,” she says. It’s a herculean task, Friedman says. “There have been whole books written around why this is an impossible thing to solve,” he says. “I don’t have the hubris to view it as something that’s coming out any day now.”
That’s why Fitbit is taking a broad approach and is considering all the ways it might be able to incorporate pulse arrival time and blood pressure into the data it offers users, Friedman says. Even if companies can’t directly measure blood pressure through a watch, they might be able to use metrics like pulse arrival time to give people information about swings in their blood pressure (like Apple is reportedly pursuing) or their general fitness levels. “We’re ultimately looking at the maximal health impact we can achieve, and there are a lot of things that would also be quite satisfying,” Friedman says.
Validating the tech
There’s more and more data available on non-cuff blood pressure monitors — movement in the right direction, Navar says. “There’s been a lot of progress in terms of trying to validate that technology against what we would consider more of a gold-standard blood pressure measurement,” she says.
Right now, the only way to access Samsung’s blood pressure feature in the US is through Mendes’ research program at the University of California San Francisco, My BP Lab, which tracks stress and blood pressure. The team asked 123 participants to spend a week taking blood pressure readings using both a blood pressure cuff and a Samsung Note 9 phone (which includes the same sensor as the smartwatches).
“It’s so, so important that we get it right,”
The analysis, published in July, found that the blood pressures calculated by the Samsung device had “moderate to strong agreement” with pressures measured by an FDA-approved cuff. The results were about as close together as the results from two different FDA-approved cuffs were each other, Mendes says. The results held for people of varying skin tones and ages.
Navar hopes to see public data on devices made by companies like Fitbit and Apple, as well. “We’ve seen companies really hold themselves to a higher standard, and I think the clinical research community is really demanding it.”
Still, Cohen says the data available so far isn’t enough to make her confident in blood pressure tracked through a smartwatch. “I wouldn’t recommend somebody use it to diagnose hypertension or for monitoring or treatment of high blood pressure. Not yet,” she says.
Fitbit wearables don’t measure blood pressure yet, but the company is studying whether it can use other metrics, like pulse arrival time, to measure people’s blood pressure.
Image: Fitbit
It’s important to get right — maybe more important than something like heart rate, Cohen says. “High blood pressure is such a major risk factor for stroke, major cardiac events, and kidney disease,” she says. “It’s so, so important that we get it right, because if devices are giving you an inaccurate reading, you can get very false reassurance that your blood pressure is normal.”
Cohen’s seen multiple patients with inaccurate data collected through blood pressure-monitoring wearables purchased overseas, or that don’t make the type of medical claims that would require clearance from the FDA. “I had one patient that had one of those watches that she got from overseas, and she was convinced her blood pressure was perfect,” she says. A monitoring test showed that it was actually 50 points higher than what the watch said. The patient was so reluctant to accept that determination that her care team had to run a second test. “She wouldn’t accept the values,” Cohen says.
“We have to be cautious”
Clinicians will have to carefully examine any new device on the market to make sure it’s working well enough to trust in different groups of people, including people with high or abnormal blood pressure, Navar says. “It may work in someone with totally normal blood vessels, but does it work in an older person who may have stiffer blood vessels? We have to be cautious,” she says.
Blood pressure is relatively easy to double check with a medical-grade cuff at home or in the doctor’s office, Navar says. She’d want to use that as a backup for patients with smartwatches, at least at first. “I’d probably want to make sure that, if somebody is using one of these watches to measure their blood pressure, that we check it against a more standard measure,” she says.
If smartwatches are able to run the validation gauntlet and prove that they can reliably track blood pressure, it could help expand the options people have to manage a health condition at home. “I love the idea of more people checking their blood pressure at home, and anything to help people do that is wonderful,” Cohen says. “But it needs to be accurate or it’s of no value.”
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Forecast of Ferric Fluoride Market Segment Trends, 2021
Forecast of Ferric Fluoride Market Segment Trends, 2021
A new method known as ferric fluoride market research reveals a number of promising opportunities for companies in this industry. The ferric fluoride market is segmented according to various uses and categories. All segments are analyzed and then forecast based upon Revenue and volume from 2021 to 2021. In addition, market research also gives qualitative and quantitative analysis of each category to understand the influencing factors for the fast growing category.
Global ferric fluoride market includes four main applications in which markets for ferric fluoride are growing: domestic water treatment, industrial waste water treatment, municipal solid waste water treatment, and public health. Domestic market is segmented according to various cities including New York, San Francisco, London, and Paris. Each city's services are analyzed for growth potential. Industrial waste water treatment application includes areas like beverage treatment, municipal solid waste water treatment, and carbonation processing.
Market analysis reveals that there is significant scope for growth in the ferric fluoride market research report according to several factors. The topmost factor contributing to growth is the cost factor. Various markets including domestic give ample opportunity to manufacturers to customize products based on cost efficacy. As fluoride use is growing in urban nations, manufacturers are exploring ways to bring fluoride to homes at affordable prices with active ingredients that are safe enough for daily consumption.
However, despite of cost advantages, some countries are reluctant to adopt fluoride programs due to various socio-economic implications. As a result, manufacturers are exploring alternate sources that can address these issues. Data forecast shows that the demand for ferric fluoride will continue to grow over the next few years. Other key regions that have large volumes of the substance include China and India. Top 5 countries accounting for majority of global production are Italy, France, China, the US, and Germany.
This data forecast discusses the key regions that are witnessing robust growth in the chemical industry. The top five markets that account for almost half of the world's production are listed as follows: India, China, Japan, the European Union, the United States, and Mexico. Among the top markets, New Delhi, Mumbai, and Guangzhou are reported to be the major players. The key trends landscape of chemical industry shows that emerging economies like India, China, and the European Union will dominate the list in near future.
In the coming years, markets like Delhi will increasingly become one of the major players. It is predicted that by 2021, Delhi will emerge as one of the leading industrial centers in India. This is because a number of multinational corporations from different segments of the market will set base in India. Indian manufacturers are currently facing stiff competition from Chinese and Japanese manufacturers due to rising costs, quality issues, and subsidies. However, with ferric fluoride market segments maturing in various parts of the country, Indian manufacturers will surely emerge as strong competitors in international markets.
The research team projects that the Ferric Fluoride market size will grow from XXX in 2020 to XXX by 2027, at an estimated CAGR of XX. The base year considered for the study is 2020, and the market size is projected from 2020 to 2027.
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By Market Players: Advance Research Chemicals, Inc. (ARC) American Elements Fisher Scientific Sigma-Aldrich (Merck) Alfa Aesar Santa Cruz Biotechnology SynQuest Labs, Inc.
By Type Anhydrous Ferric Fluoride Ferric Fluoride Trihydrate
By Application Ceramics Industry Chemical Industry Others
By Regions/Countries: North America United States Canada Mexico
East Asia China Japan South Korea
Europe Germany United Kingdom France Italy Russia Spain Netherlands Switzerland Poland
South Asia India Pakistan Bangladesh
Southeast Asia Indonesia Thailand Singapore Malaysia Philippines Vietnam Myanmar
Middle East Turkey Saudi Arabia Iran United Arab Emirates Israel Iraq Qatar Kuwait Oman
Africa Nigeria South Africa Egypt Algeria Morocoo
Oceania Australia New Zealand
South America Brazil Argentina Colombia Chile Venezuela Peru Puerto Rico Ecuador
Rest of the World Kazakhstan
Points Covered in The Report The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analyzed 12 years data history and forecast. The growth factors of the market is discussed in detail wherein the different end users of the market are explained in detail. Data and information by market player, by region, by type, by application and etc, and custom research can be added according to specific requirements. The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.
Key Reasons to Purchase To gain insightful analyses of the market and have comprehensive understanding of the global market and its commercial landscape. Assess the production processes, major issues, and solutions to mitigate the development risk. To understand the most affecting driving and restraining forces in the market and its impact in the global market. Learn about the market strategies that are being adopted by leading respective organizations. To understand the future outlook and prospects for the market. Besides the standard structure reports, we also provide custom research according to specific requirements.
The report focuses on Global, Top 10 Regions and Top 50 Countries Market Size of Ferric Fluoride 2016-2021, and development forecast 2022-2027 including industries, major players/suppliers worldwide and market share by regions, with company and product introduction, position in the market including their market status and development trend by types and applications which will provide its price and profit status, and marketing status & market growth drivers and challenges, with base year as 2020.
Key Indicators Analysed Market Players & Competitor Analysis: The report covers the key players of the industry including Company Profile, Product Specifications, Production Capacity/Sales, Revenue, Price and Gross Margin 2016-2021 & Sales by Product Types. Global and Regional Market Analysis: The report includes Global & Regional market status and outlook 2022-2027. Further the report provides break down details about each region & countries covered in the report. Identifying its production, consumption, import & export, sales volume & revenue forecast. Market Analysis by Product Type: The report covers majority Product Types in the Ferric Fluoride Industry, including its product specifcations by each key player, volume, sales by Volume and Value (M USD). Markat Analysis by Application Type: Based on the Ferric Fluoride Industry and its applications, the market is further sub-segmented into several major Application of its industry. It provides you with the market size, CAGR & forecast by each industry applications. Market Trends: Market key trends which include Increased Competition and Continuous Innovations. Opportunities and Drivers: Identifying the Growing Demands and New Technology Porters Five Force Analysis: The report will provide with the state of competition in industry depending on five basic forces: threat of new entrants, bargaining power of suppliers, bargaining power of buyers, threat of substitute products or services, and existing industry rivalry.
COVID-19 Impact Report covers Impact of Coronavirus COVID-19: Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Ferric Fluoride market in 2021. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.
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All the companies from Y Combinator’s W20 Demo Day, Part III: Hardware, Robots, AI and Developer Tools
Y Combinator’s Demo Day was a bit different this time around.
As concerns grew over the spread of COVID-19, Y Combinator shifted the event format away from the two-day gathering in San Francisco we’ve gotten used to, instead opting to have its entire class debut to invited investors and media via YC’s Demo Day website.
In a bit of a surprise twist, YC also moved Demo Day forward one week, citing accelerated pacing from investors. Alas, this meant switching up its plan for each company to have a recorded pitch on the Demo Day website; instead, each company pitched via slides, a few paragraphs outlining what they’re doing and the traction they’re seeing, and team bios. It’s unclear so far how this new format — in combination with the rapidly evolving investment climate — will impact this class.
As we do with each class, we’ve collected our notes on each company based on information gathered from their pitches, websites and, in some cases, our earlier coverage of them.
To make things a bit easier to read, we’ve split things up by category rather than have it be one huge wall of text. These are the companies that are working on hardware, robotics, AI, machine learning or tools for developers. You can find the other categories (such as biotech, consumer, and fintech) here.
AI and Machine Learning
Datasaur: A tool meant to help humans label machine data data sets more accurately and efficiently through things like auto-correct, auto-suggest and keyboard hotkeys. It’s free for individual labelers, $100 per month for teams of up to 20 labelers, with custom pricing for larger teams.
1build: Automatic, data-driven job cost estimates for construction companies. You upload your plans, and 1build says it can prepare accurate bids “in minutes.” The company projects a revenue run rate of over $600,000, and says it has completed estimates for mega companies like Amazon, Starbucks and 7-Eleven.
Handl: An API for turning paper documents — including handwritten ones — into structured data ready to be plunked into a database or CRM. While the company says that around 85% of its processing is handled by their AI, it’s backed by humans to validate data when the AI’s confidence is low. Nine months after launch, the company is seeing an ARR of $0.9 million.
Zumo Labs: Uses game engines to generate pre-labeled training data for computer vision systems. By synthesizing the data rather than collecting it from photos/videos of the real world, the company says it can create massive data sets faster, cheaper and without privacy issues.
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Teleo: Retrofits existing construction equipment to allow operators to control them remotely. The company says it has built a “fully functional teleoperated loader” since being founded three months ago, and plans to charge construction companies a flat monthly fee per vehicle. The company’s co-founders were previously head of Hardware Engineering and director of Product Manager at Lyft, with both having worked on Google’s Street View team.
Menten AI: Menten AI says it’s using “quantum computing and machine learning” combined with synthetic biology to design new protein-based drugs.
Turing Labs Inc.: Automated, simulated testing of different formulas for consumer goods like soaps and deodorant. Home products and cosmetics can be months of work for R&D labs. Turing has built an AI engine that helps with this process — much like the AI engines used in drug discovery — cutting down the time to days. It’s already working with some of the biggest CPG companies in the world. You can find our previous coverage on Turing here.
Segmed: Segmed is building data sets for AI-driven medical research. Rather than requiring each and every researcher to individually partner with hospitals and imaging facilities, Segmed partners with these organizations (currently over 50) and standardizes, labels and anonymizes the data.
Ardis AI: Ardis AI wants to build the foundation of artificial general intelligence — technology that read and comprehend text like a human. By combining neural networks, symbolic reasoning and new natural language processing techniques, Ardis AI can serve companies that don’t want to hire teams to do data extraction and labeling.
Agnoris: Agnoris analyzes a restaurant’s point-of-sale data to recommend changes to pricing, delivery menus and staffing. For $3,600 per year per restaurant location, Agnoris claims to be able to raise profits by 20%. The company started after the founder opened a restaurant that was packed yet losing money, so it built machine learning tools to improve margins and now it’s selling that software to all eateries.
Froglabs: Froglabs provides weather forecasting AI to businesses for predicting solar and wind energy production, delivery delays, staffing shortages, sales demand and food availability. By ingesting petabytes of weather data, it can save companies money by ensuring their logistics aren’t disrupted. Founded by a long-time Googler who started its Project Loon internet-beaming weather balloons, it’s now signing up e-commerce, retail, rideshare, restaurant and event businesses.
PillarPlus: PillarPlus is a platform that automates the blueprint-designing phase of a building project. It takes a design from an architect or contractor and maps out mechanical, fire, electrical and plumbing details, and estimates the bill of materials and project cost, steps that otherwise take months of work.
Glisten: Glisten uses computer vision and machine learning technologies to develop better, more consistent data sets for e-commerce companies. Its first product is an AI-based tool to populate and enrich sparse product data. Find our previous coverage of Glisten here.
nextmv: Nextmv gives its customers the ability to create their own logistics algorithms automatically — allowing businesses to optimize fleets and manage routes internally.
Visual One: Movement-detecting security cameras can bring up a lot of false positives: there’s motion, yes, but not necessarily anything harmful. Visual One has built an AI platform that integrates with home security cameras to “read” the specific movements that they detect. Owners can create customised alerts so they get notifications only for what they care about. The company’s software can check for furniture-destroying pets, package-lifting thieves, the death-defying antics of toddlers and more. Find our previous coverage of Visual One here.
PostEra: “Medicinal chemistry-as-a-service” is the idea here: PostEra’s platform can design and synthesize molecules faster and at a lower cost than the typical R&D lab, speeding up the research time it takes to test new combinations in the drug discovery process.
Hardware and Robotics
Cyberdontics: Robotics have already revolutionized surgery, courtesy of companies like da Vinci-maker, Intuitive. Cyberdontics is aimed at doing the same for oral surgery, beginning with crowns — one of the more expensive and time-intensive procedures. The company says its robot is capable of performing the generally two-hour procedure in 15 minutes, charging a mere $140 for the job.
Avion: Focused on inhabitants of difficult to reach areas in Africa, Avion is building a drone-based delivery system. The plans consist of medium and long-range medical drones tied to a centralized hub. The drones are hybrid and autonomous with vertical take-off capabilities, able to take 5-kg payloads as far as 150 kms.
SOMATIC: Industrial bathroom cleaning is a prime “dull”/“dirty” candidate to be replaced by automation. Somatic builds large robots that are trained to clean restrooms via VR. The system sprays and wipes down surfaces and is capable of opening doors and riding up and down in the elevator. Find our previous coverage of SOMATIC here.
RoboTire: Anyone who’s ever sat in a service shop waiting room knows how time-intensive the process can be. RoboTire promises to cut the wait time from 60 minutes down to 10 for a set of four tires. The company has begun piloting the technology in locations around the U.S. Find our previous coverage of RoboTire here.
Morphle: Designed to replace outdated analog microscopes, Morphle’s system uses robotic automation to improve imaging. The startup processes higher-resolution images than far pricier systems and with a much smaller failure rate. Morphle has begun selling its system to labs in India.
Daedalus: Founded by an early engineer at OpenAI, Daedalus is building autonomous software to allow industrial robots to operate without human programming, beginning with CNC machines. The company projects that it can improve productivity in the metal machining market by 5x.
Exosonic, Inc.: Exosonic makes supersonic commercial aircraft that don’t have to produce a loud sonic boom, so they can be flown over land. Its goal is a plane that can fly from SF to NYC in three hours. The CEO worked on NASA’s low-boom X-59 aircraft while at Lockheed Martin. Exosonic now has letters of intent from a major airline and two Department of Defense groups, plus a $300,000 U.S. Air Force contract.
Nimbus: Founded by a serial entrepreneur and based in Ann Arbor, Mich., Nimbus is developing the next-generation vehicle platform for urban transportation. Founder Lihang Nong previously launched the fuel-injection systems developer PicoSpray and is now looking to answer the question, “Can a vehicle be several times more space and energy efficient than today’s cars while actually being more comfortable to ride in?”
UrbanKisaan: UrbanKisaan is a vertical farming operation based in India that delivers fresh produce subscriptions to households. Its farms of stacked-up hydroponic tables can be located near cities with just 1% of the land usage of traditional agriculture, and there are no pesticides necessary. In a market with a growing middle class seeking healthy foods, delivering from farm-to-door could let UrbanKisaan control quality and its margins.
Talyn Air: Two former SpaceX engineers have developed a long-range electric vertical take-off and landing (eVTOL) aircraft for passengers and cargo. The startup has created an electric fixed-wing aircraft that is caught mid-air with a custom winged drone during take offs and landings, an approach that its founders say give this aircraft three times the range of its competitors, at 350 miles.
Developer Tools
BuildBuddy: Two ex-Googlers want to provide a “Google-style development environment” to all by building an open-source UI/feature set on top of Google’s Bazel software. The company says that their solution speeds up build times by up to 10x. It’s free for independent developers, with the price scaling from $4 per user to $49 per user depending on the size of the team and the features required.
Dataline: Meant to let websites gather analytics data from users who are using ad-blocking tools. Claiming that most ad-blocker users care mostly about display ads or cross-site tracking, the company says that first-party analytics gets hit as “collateral damage.” By acting as a “smart proxy” that runs on a sub-domain, Dataline avoids most ad-blocking systems (for now, presumably.)
Cortex: Many modern online software applications are powered by countless independent, purpose-focused tools — or “microservices.” Cortex monitors your app’s microservices to automatically flag the right person (hooking into Datadog/Slack/PagerDuty/etc.) when one breaks.
apitracker: Even if your website seems to be loading fine, the APIs you use to make it work might be having trouble, breaking things in not so obvious ways. Apitracker… tracks your APIs. It monitors the APIs you use, alerting you when one of them starts to fail and providing insights into their overall performance.
Freshpaint: Freshpaint’s “autotrack” system collects all pageviews/clicks/etc. across your site, allowing you to push it into tools like Google Analytics/Facebook Pixel etc. retroactively without requiring your dev team to make manual trackers for each event. The base plan is free for sites with fewer than 3,000 users and $300 for sites with up to 50,000 monthly users, after which point the pricing shifts to custom packaging.
Datree: Datree allows companies to set up rules and security policies for their codebase, and ensures those rules are followed before any code is merged. Charging $28 per developer (noting that it’s free for independent/open source projects), they’ve pulled in ~$230K in revenue to date. Find our previous coverage of Datree here.
fly.io: Deploys your app on servers that are physically closer to your users, decreasing latency and improving the user experience. If your app grows more popular in a certain city, Fly detects that and scales resources accordingly.
Sweeps: Sweeps claims that they can make your website 40% faster with one line of code, by more intelligently loading all of the third-party tools that a website is using. The team says that their tech not only improves speed but does so while improving SEO.
Orbiter: Orbiter is an automatic real-time monitoring and alert system integrated with Slack to ensure better customer service and revenue management.
Release: Product releases can be tricky. Release provides a staging management toolkit — it builds a staging environment each time there’s a pull request, allowing for faster/more collaborative development cycles.
Signadot: Signadot is monitoring and management software for the microservices that modern startups rely on to power their own applications and services, hopefully flagging issues before they become apparent to the end user.
Raycast: Raycast is a universal command bar for developers and many of the tools they use. Users can integrate apps including Jira, GitHub or Slack and take a Superhuman-like approach to completing forms and tasks. The team is pitching the tool as a way to help engineers get their non-engineering work done quickly.
Cotter: Cotter is building a phone number-based login platform that authenticates a user’s device in a workflow that the company’s founders say has the convenience of SMS-based OTP without the security issues. The startup is aiming to target customers in developing countries where email is less utilized and less convenient as a login.
ditto: Ditto’s founders are hoping to create the Figma for words, helping teams plan out more thoughtfully the copy they use to describe their products and workflows. The collaboration tool created by Stanford roommates Jolena Ma and Jessica Ouyang currently has 80+ different companies represented among their users.
Scout: A continuous integration and deployment toolkit for machine learning experiments inside a GitHub workflow.
ToDesktop: ToDesktop has designed a service to automate all of your desktop application publishing needs. It works with Windows, Mac and Linux and provides native installers, auto-updates, code signing and crash reports without the need for any infrastructure or configurations for developers.
DeepSource: DeepSource is a code review tool that allows developers to check for bug risks, anti-patterns, performance issues and security flaws in Python and Go.
Flowbot: Flowbot is a natural language, autocomplete search tool for coding in Python. It lets Python developers type in plain English when they can’t remember the exact function they’re thinking of, with Flowbot digging through documentation and considering the context to find the code it thinks you’re looking for.
PostHog: PostHog is a software service that lets developers understand how their users are actually working with their products. It’s a product analytics toolkit for open-source programmers.
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Usa today Tibetan monks at turtle release, puppy rescue 911: News from around our 50 states
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Usa today Alabama
Scottsboro: Jackson County plans to reopen the park the set apart a deadly fire at a marina killed eight people a week within the past. Most of Jackson County Park will reopen Monday, officers stated, however the fragment of the marina the set apart fire took place will silent be off-limits. Paul Smith, the county emergency administration director, stated crews would be cleansing up the positioning throughout the weekend. Environmental hurt from the blaze didn’t receive exterior the rapid dwelling round the marina, he told a recordsdata convention Friday. A fireplace broke out on a dock at the marina Jan. 27, destroying about three dozen boats and claiming eight lives. Officials luxuriate in no longer particular the trigger of the fire, however they stated investigators are searching at one boat in explicit. Most burned boats that sunk within the broad creek the set apart the marina is found off the Tennessee River luxuriate in been removed, Smith stated, however some dwell. Salvage work will take “rather a whereas,” he stated.
Usa today Alaska
Juneau: Gov. Mike Dunleavy is planning city hall meetings centered on the divulge’s fiscal concern and future. Events are planned for Petersburg on Monday and Wrangell on Tuesday. Dunleavy’s region of job stated town halls will seemingly be commence to the final public. Additional public events will seemingly be announced later as fragment of a city hall sequence, his region of job stated. Dunleavy has stated he plans to more straight away keep up a correspondence with Alaskans. His first 365 days rather than job was as soon as marked by an ongoing decide effort, which was as soon as fueled by madden over funds cuts he proposed remaining 365 days. Dunleavy has referred to as the decide effort political. Apart from town halls, Dunleavy plans to meet with school and community leaders, tribes, enterprise teams and nonprofits across the divulge, essentially based on his region of job. Dunleavy told journalists Friday that the divulge is paying for the upcoming trips. He confronted criticism remaining 365 days for conserving city halls hosted by American citizens for Prosperity-Alaska.
Usa today Arizona
Flagstaff: The Metropolis Council drew an overflow crowd because it moved in direction of declaring a climate emergency to tackle climate replace and ruin carbon neutrality by 2030. With more than 250 people expose for the council’s consideration of the train at a gathering remaining week, dozens had to sit down on folding chairs within the lobby of Metropolis Hall to focal level on a livestream, the Arizona Every single day Solar reports. The council is now poised to formally adopt the determination following a honest correct overview. “We luxuriate in seen and felt the sense of emergency,” Councilwoman Regina Salas stated after rather just a few individuals of the final public spoke. The measure would be nonbinding. But activist Sara Kubisty stated declaring a climate emergency gadgets a usual that residents and voters can cite all over future policy discussions. Mayor Coral Evans stated she supported the determination however warned that extra climate motion will take valid effort and obtained’t gradually be usual.
Usa today Arkansas
Jacksonville: The Metropolis Council voted Friday to allow new tests on fingerprints and DNA evidence concerning to the case of a man the divulge set apart to death in 2017. The council voted to allow the tests that Ledell Lee’s family contends might perhaps likely perchance exonerate him of the 1993 slaying of Debra Reese. Patricia Young, Lee’s sister, had sued town to allow the new tests. Representing the family luxuriate in been the American Civil Liberties Union, the ACLU of Arkansas and the Innocence Mission. The teams stated they conception to luxuriate in the DNA evidence examined at a nationally authorized laboratory at Young’s expense and to be succesful to add the fingerprints to a national database. Lee was as soon as the first of four inmates Arkansas executed in April 2017 sooner than its provide of a deadly injection drug expired. The divulge had originally planned to originate eight inmates, however four luxuriate in been spared by court rulings.
Usa today California
San Francisco: A conservation community has reached an agreement to utilize a canyon within the Santa Cruz Mountains that involves 100 acres of gentle redwood trees, a utilize expose that will aid make a real corridor of safe redwood habitat stretching to the Pacific Ocean. Place the Redwoods League reached an agreement Thursday to utilize the 564-acre Cascade Creek, nestled between Tall Basin Redwoods and Ano Nuevo divulge parks, the San Francisco Account reports. The towering redwoods luxuriate in never felt the blade of a seen, the form to which conservationists reverently refer as “extinct-boost.” “We bought right here correct in time,” stated Sam Hodder, president and CEO of Place the Redwoods League, gesturing in direction of blue paint marks, which show they luxuriate in been as soon as the aim of loggers. The league has to this level raised $8.6 million of the $9.6 million wanted to entire the transaction, which is anticipated to shut Would possibly simply 30.
Usa today Colorado
Denver: The divulge Senate formally accredited a death penalty repeal invoice Friday and sent it to the Home, the set apart prospects for passage are favorable. Gov. Jared Polis has stated he'll label a repeal invoice. The 19-13 vote got right here within the seventh effort in contemporary years to repeal the divulge’s death penalty. The invoice would apply to offenses charged on or after July 1. It wouldn't apply to the three males on Colorado’s death row. That provision was as soon as added to the invoice at the conclusion of an hourslong Senate ground debate Thursday. Democratic Sen. Rhonda Fields of Aurora as soon as more entreated her colleagues to preserve capital punishment – or at the very least refer the search recordsdata from to voters. Colorado’s remaining execution got right here in 1997. Twenty-one U.S. states luxuriate in abolished capital punishment. Other states are for the time being brooding about motion.
Usa today Connecticut
Hartford: The divulge is giving $1.3 million to aid dwelling victims of domestic violence and human trafficking, advocates state. The divulge’s Division of Housing and Coalition In opposition to Home Violence announced a new round of funding Thursday, the Hartford Courant reports. The coalition stated the cash will allow the 2 divulge agencies continue to search out safe housing for victims who're fleeing intimate accomplice violence and human trafficking. The brand new funding adopted an preliminary $1.7 million got remaining 365 days when the 2 agencies began to collaborate of their effort to dwelling victims of abuse and human trafficking. Gov. Ned Lamont commended the agencies’ efforts and stated the divulge has been a pacesetter “on issues touching on domestic and family violence and offering protections for survivors, and adorning these providers stays a priority.”
Usa today Delaware
Dover: Democratic Gov. John Carney is proposing to amplify the divulge’s working funds by almost 4% subsequent fiscal 365 days, boosting spending to more than $4.6 billion. The funds proposal unveiled Thursday for the fiscal 365 days beginning July 1 involves a 2% pay elevate for divulge workers, who also got pay raises remaining 365 days and the 365 days sooner than, at a $29.3 million impress to taxpayers. Carney’s proposed working funds involves $36.5 million in new spending to tackle school enrollment boost. He’s also proposing a file capital funds of $892.8 million for construction, maintenance, skills, equipment, economic type and environmental initiatives. The proposal involves $50 million in new spending for trim water initiatives, $50 million for economic type, and $50 million to luxuriate in and renovate colleges in Wilmington.
Usa today District of Columbia
Washington: A new ogle has been granted $1 million to determine who would qualify for free or discounted fares on Metro, officers state. The district’s social science heart referred to as The Lab got $1 million in grant funding to lag the ogle, WUSA-TV reports. Town says 18% of all Metrorail riders are conception to be low-earnings, and that quantity jumps to 48% on Metrobus. Metropolis Administrator Rashad Young says the ogle ensures town does no longer ruin its cash, because it might perhaps perhaps perhaps likely perchance within the ruin pay Metro for income it loses. Researchers state they wish the device to be seamless with SmarTrip playing cards, in all likelihood linked to databases of different social providers, be pleased food stamps. Young also says the assumption might perhaps likely perchance no longer be a handout in a city the set apart getting round can bankrupt these making an strive to construct ends meet. Officials state 2,500 adults will seemingly be asked to participate within the ogle beginning this summer season.
Usa today Florida
Islamorada: Visiting Tibetan monks helped free up a rehabilitated sea turtle within the Florida Keys. A complete bunch of spectators witnessed the free up Thursday of “Drifter,” a 170-pound female adult loggerhead sea turtle who was as soon as rehabilitated at the Keys-essentially based Turtle Health heart after she was as soon as chanced on floating offshore of the Lower Keys remaining November. The monks hail from the Drepung Gomang Monastery in India. “Drifter” was as soon as launched into the Atlantic Ocean off an Islamorada resort after an hourlong ceremony performed by the monks, every an ordained student of the Dalai Lama. Ritual chants aspired that the turtle and other animals revel in long lives. Minyak Rinpoche, the community’s chief, stated essentially the major to remaining happiness is compassion for all residing things and loving kindness. Workers at the Turtle Health heart luxuriate in been rescuing, rehabilitating and returning turtles to the wild for nearly 35 years.
Usa today Georgia
Atlanta: Anne Cox Chambers, a newspaper heiress, diplomat and philanthropist who was as soon as one in every of the nation’s richest females, died Friday at the age of 100. Chambers’ nephew James Cox Kennedy announced her death to The Atlanta Journal-Constitution, her company’s flagship newspaper. Chambers, a director of Cox Enterprises Inc., promoted Jimmy Carter’s political career and served as U.S. ambassador to Belgium all over his presidency. Forbes estimated her earn price lots of years within the past at virtually $17 billion. She was as soon as successfully recognized for her charitable giving and served on the boards of the Atlanta Arts Alliance and the Excessive Museum of Artwork, among other institutions. She owned a white-columned manor across from the governor’s mansion in Atlanta, the set apart Jimmy Carter brought his daughter, Amy, over to swim within the pool. Gov. Brian Kemp issued a assertion Friday praising Chambers, saying her “contributions to town of Atlanta and the divulge of Georgia will seemingly be felt for generations to come.”
Usa today Hawaii
Honolulu: Legislation enforcement officers from round the nation gathered within town for a ceremony to honor one in every of two officers killed whereas responding to a name all over which a suspect and his landlord died and nearby homes luxuriate in been leveled by fire. Officer Tiffany Enriquez was as soon as memorialized Thursday by her family, individuals of the final public, and police officers and emergency personnel who formed a “skinny blue line” at the Honolulu Police Division headquarters as fragment of Enriquez’s “ruin of focal level on” ceremony. Enriquez, 38, was as soon as a seven-365 days historical of the Honolulu police assigned to Waikiki. The Air Pressure historical was as soon as the first female officer to die within the line of accountability in Hawaii when she was as soon as fatally shot Jan. 19 in conjunction with Officer Kaulike Kalama. Authorities state Jaroslav Hanel, 69, shot the officers and killed landlord Lois Cain in a suspected landlord-tenant dispute.
Usa today Idaho
Boise: The divulge’s roads are changing into more and more unhealthy with distracted drivers and a rising series of motorists, the director of the Idaho Division of Transportation says. “Drivers are more distracted than ever sooner than,” Brian Ness told divulge lawmakers on a funds-surroundings committee Friday. “And I have faith skills might perhaps likely perchance very successfully be accountable for powerful of that.” Legislation to impose a statewide ban on handheld cellular phone utilize whereas using is pending within the Senate, and distracted using guidelines is pending within the Home. Ness isn’t taking an arena on the guidelines, however his company is working a campaign geared in direction of having people set apart away distractions whereas using. Ness was as soon as sooner than the committee to inform his company’s funds. Republican Gov. Brad Diminutive has proposed a 7.9% amplify from remaining 365 days to $785 million. The committee obtained’t originate up surroundings divulge company budgets for lots of more weeks.
Usa today Illinois
Chicago: Town is suing a espresso company for trademark infringement, saying its designate is virtually a lot just like the image for town’s fire department. Fireplace Division Espresso’s designate capabilities the letters F, D and C, intertwined in a stylized monogram, correct be pleased the one for the Chicago Fireplace Division, the Chicago Solar-Instances reports. The construct is seemingly worn to confuse patrons into pondering town has counseled or backed the enterprise, essentially based on the lawsuit filed Thursday. Firefighters lag the Rockford-essentially based company, and “10% of proceeds from every expose goes in direction of supporting ill or injured firefighters and first responders,” essentially based on its internet internet site. “Fireplace Division Espresso pursued all of the comely comely channels and secured an accredited, registered trademark for our most up-to-date Fireplace Division Espresso designate,” the company stated in a assertion.
Usa today Indiana
Indianapolis: Four individuals of the Indianapolis Metropolis-County Council openly title as individuals of the LGBTQ community, which is essentially the most ever for the legislative body. Newly elected member Ali Brown, who is bisexual, says none of the candidates obtained in November for that motive. “None of that was as soon as fragment of (anything else) groundbreaking or anything else be pleased that,” Brown says. “It was as soon as correct one thing that was as soon as.” But LGBTQ advocates hope it manner their issues are larger heard. “Basically the most productive expectation we now luxuriate in is that they hear to our community and provide a voice to the issues major to our community,” says Chris Handberg, executive director of Indy Pleasure. “Whereas within the past, we now luxuriate in no longer had straightforward receive admission to to lawmakers and politicians and leaders in mumble to provide just a few of that.” The candidates luxuriate in been elected as fragment of a Democratic wave on the council. Indiana’s legislature is overwhelmingly Republican.
Usa today Iowa
Des Moines: A divided divulge Supreme Court docket concluded Friday that a central Iowa leisure lake that householders tout as the divulge’s largest non-public lake isn’t non-public at all because it is accessible through a public waterway. The ruling can luxuriate in ramifications for non-public lake traits connected to rivers that favor to preserve out nonmember boaters. It’s no longer straight away decided how many lakes within the divulge would be affected. The 4-2 determination got right here within the case of Jeffrey Alan Meyers, who was as soon as arrested by Iowa Division of Natural Resources officers for boating whereas intoxicated on Lake Panorama in July 2018. The DNR officers initially stopped Meyers’ pontoon boat on the lake because it was as soon as embellished with blue lights, violating an Iowa law against showing blue lights on a boat that’s no longer an emergency vessel. DNR officers claimed they'd jurisdiction since the lake is attached to the publicly accessible Heart Raccoon River.
Usa today Kansas
Lawrence: As the Neat Bowl neared, University of Kansas college students entreated directors to name off classes on the day after the broad sport and to provide vomit baggage on campus if they didn’t. The Pupil Senate made the quiz in a determination passed Thursday as the Kansas Metropolis Chiefs ready to play the San Francisco 49ers on Sunday within the crew’s first run to the Neat Bowl since 1970. It stated Chancellor Douglas Girod must silent preserve in mind the “successfully being implications of school students attending classes and making an strive course work less than 12 hours after the culmination of the Neat Bowl and any celebrations that practice the sport, must silent the Kansas Metropolis Chiefs emerge victorious.” The determination also stated Pupil Senate individuals don’t condone the tradition of followers mimicking tomahawk chops or “any other behavior that mocks or is offensive to Native American culture.” They entreated the Chiefs to “take proactive makes an strive to entire such traditions.”
Usa today Kentucky
Louisville: The series of vacationers taking flights at the Louisville Muhammad Ali Global Airport remaining 365 days space a file, officers stated. The airport announced in a assertion on Thursday that 2019 was as soon as its busiest 365 days but with 4.2 million passengers. That’s virtually 300,000 more than it had in 2000, when there luxuriate in been 3.9 million passengers. “Exceeding the 4 million designate is one thing we're very happy with and is a new milestone for our airport,” stated Dan Mann, executive director of the Louisville Regional Airport Authority. “We perceive how profitable 2019 was as soon as for passenger internet site visitors, and we believe the numbers for 2020 will seemingly be even larger.” Closing 365 days, the six airways serving Louisville elevated potential on 20 completely different routes in conjunction with the addition of nonstop flights to more than one areas. “Verbalize flights are major in making us stunning for agencies and internet site visitors,” stated Louisville Mayor Greg Fischer.
Usa today Louisiana
Baton Rouge: Gov. John Bel Edwards’ administration reached but another deadlock Friday over the divulge’s earnings forecast, unable to strike a take care of the Legislature’s new Republican leaders about be taught how to space the projections worn to luxuriate in the funds. The Democratic governor had been hopeful that a replace within the Home’s top leadership would ruin through repeated logjams over the forecast and give him the updated, larger divulge earnings forecast he wanted as he crafts his funds proposal for subsequent 365 days. As an different, the Edwards administration chanced on itself at odds with each the new Republican Home Speaker Clay Schexnayder and new GOP Senate President Net page Cortez all around the most up-to-date meeting of the Income Estimating Conference. Both expressed issues about the numbers proposed by nonpartisan legislative and administrative economists that the governor’s chief funds adviser wanted to make utilize of.
Usa today Maine
Portland: Allen’s Espresso Brandy, a delicate designate of liquor cherished in Maine, will not be any longer any longer the tip-selling alcohol within the Pine Tree Issue. Issue alcoholic beverage recordsdata state Mainers spent $12.2 million on Fireball Cinnamon Whiskey and $11.7 million on Tito’s Handmade Vodka remaining 365 days, the Bangor Every single day Recordsdata reports. Those sales luxuriate in been ample to eclipse Allen’s, which garnered $9.2 million in sales. Allen’s stays essentially the most-bought onerous alcohol within the divulge by manner of quantity. Folks bought more than 90,000 cases of Allen’s in Maine remaining 365 days, whereas Tito’s got right here in 2nd at 71,000. Allen’s is produced by M.S. Walker of Massachusetts. Gross sales are trending downward, though. Income of Allen’s has dropped by about a sixth since 2014. Closing 365 days’s sales lagged about $400,000 within the aid of the 2018 figure. Maine is the supreme indispensable marketplace for Allen’s, which is in particular usual in a milk-essentially based blended drink referred to as a “Sombrero.”
Usa today Maryland
Bel Air: Town’s police chief has been positioned on administrative wander away after being accused of physical and verbal fights with his estranged accomplice and teenage son. Charles A. Moore Jr., chief of Bel Air police, was as soon as served a transient protective expose Tuesday, recordsdata outlets fable. Deputy Chief Richard Peschek will aid as chief in Moore’s absence, city officers state. Moore and his accomplice separated in 2016, essentially based on court paperwork bought by The Aegis, a division of The Baltimore Solar. In December, Moore and his adult son went to his accomplice’s dwelling, the set apart Moore allegedly bought into an argument with his teenage son and attempted to choke the boy after being punched by the teen, court paperwork divulge. Jason Silverstein, Moore’s attorney, stated his client is the victim, the newspaper reports. Moore was as soon as also accused of sending “belittling textual state messages” to his accomplice and perilous to to “bash her head,” essentially based on the paperwork.
Usa today Massachusetts
Boston: Bay Issue voters who can’t receive to their native polling space for the upcoming presidential primaries can now make a choice up absentee ballots. Voters who will seemingly be out of city March 3 or luxuriate in a incapacity or non secular perception that prevents them from voting at their polling region are eligible to vote by absentee ballot. Of us that want a pollmailed to them might perhaps likely perchance ship an absentee pollsoftware program to their city or city hall. Family individuals might perhaps likely also entire the software program on a voter’s behalf. Secretary of the Commonwealth William Galvin is recommending voters put up absentee pollcapabilities as soon as that that you just might perhaps perhaps imagine to allow time for the pollto be mailed to the voter and returned to their city or city hall. Ballots need to be delivered to the native election region of job by the shut of polls March 3 in expose to be counted. Early voting will even be on hand Feb. 24-28 for all voters.
Usa today Michigan
St. Clair Shores: Those who dwell alongside the shores of Lake St. Clair are questioning how powerful this is in a position to likely impress them to trim up a sludge-be pleased substance that honest no longer too long within the past washed up on their properties. Exams of samples taken from one property in Macomb County, in southeastern Michigan, confirmed the substance to be decaying algae containing E. coli micro organism, the county successfully being department stated in a free up. Health officers luxuriate in stated the algae presents “no imminent public successfully being hazard.” But to hoover the topic topic up the utilize of a sanitary truck and then dispose it might perhaps perhaps perhaps likely perchance impress about $10,000 per dwelling, essentially based on Ryan Siarkowski, the proprietor of Synergy Constructing Specialist. This might perhaps perhaps likely impress more if a dwelling owner also removes the soil underneath the topic topic, stated Siarkowski, who well-known that every dwelling would be completely different. Lake St. Clair feeds into the Detroit River and is fragment of the waterway linking lakes Huron and Erie.
Usa today Minnesota
Duluth: The breathtaking ice caves alongside the Apostle Islands National Lakeshore is gradually inaccessible this 365 days due to low ice coverage on Lake Superior. On Friday, less than 5% of Lake Superior was as soon as covered by ice; ice coverage is often 25% at the tip of January. The Huge name Tribune reports the remaining time the ice caves luxuriate in been accessible by foot was as soon as in 2015. Whereas ice coverage on Superior usually peaks in February or March, recordsdata reveals most winters with this stage of ice Jan. 31 don’t gain powerful more. A University of Michigan ogle remaining 365 days stated monitoring ice on the Gigantic Lakes is an supreme case ogle for climate research. Ice surrounding the Bayfield Peninsula was as soon as more constant sooner than the late 1990s, when “impulsively we seen years all over which there was as soon as no safe ice duvet,” stated Andrew Gronewold, a ogle author. Apostle Islands National Lakeshore is celebrating its 50th anniversary this 365 days.
Usa today Mississippi
Oxford: Frail Fox Recordsdata Channel anchor Shepard Smith is decided to get a journalism award from his alma mater, the University of Mississippi. The university’s College of Journalism and Fresh Media announced in a recordsdata free up that Smith is the most up-to-date to be honored with its Silver Em award. Smith will get the award all over a ceremony April 1 in Oxford. Smith, who grew up in Holly Springs, spent more than 20 years anchoring Fox Recordsdata sooner than leaving the network remaining 365 days. “Shepard Smith embodies what a journalist need to be – for decades, he has reported the suggestions without concern or desire,” stated Debora Wenger, assistant dean for innovation and exterior partnerships and professor of journalism. “On myth of he bought his originate up in journalism right here at the University of Mississippi, we feel terribly happy with all he has done.”
Usa today Missouri
Jefferson Metropolis: Lawmakers this session are making an strive to construct it more uncomplicated for military spouses and out-of-divulge doctors, lecturers, pharmacists and other licensed professionals to receive jobs within the divulge. Legislation accredited by the divulge Home remaining week would allow these professionals to work within the divulge without going through its licensing course of. One invoice would construct the exception most productive for military spouses, who might perhaps likely perchance switch many times. That invoice wouldn’t allow military spouses to switch teaching licenses to Missouri. One other invoice would apply what’s referred to as license reciprocity to all out-of-divulge professionals. Republican Gov. Mike Parson referred to as for license reciprocity for military spouses all over his January Issue of the Issue take care of to the Republican-led Legislature. He told Home and Senate sponsors of the measure that he’s reckoning on them to ship guidelines to his desk “very soon.”
Usa today Montana
Helena: The U.S. Division of Agriculture granted a secretarial pure catastrophe designation to 17 counties that requested federal aid after incurring losses triggered by more than one mess ups all around the 2019 nick 365 days, Gov. Steve Bullock stated Friday. The designation will construct producers eligible for particular aid from the Farm Carrier Company, in conjunction with emergency loans. The farmers luxuriate in eight months to utilize for the loans. The counties designated are Cascade, Chouteau, Daniels, Dawson, Glacier, McCone, Pondera, Prairie, Richland, Roosevelt, Rosebud, Sheridan, Teton, Toole, Treasure, Valley and Wibaux. Bullock sent two letters to Agriculture Secretary Sonny Perdue soliciting for a secretarial catastrophe designation for lots of counties that had more than one mess ups, in conjunction with excessive moisture and snow, freezing, frost, hail and high winds.
Usa today Nebraska
Kearney: Officials are investigating how a pair of teen offenders managed to lag custody twice in a 24-hour duration. The incident began Tuesday evening when a fable of two suspicious males led the Buffalo County Sheriff’s Place of job to name the Formative years Rehabilitation and Remedy Heart in Kearney to sight if it was as soon as missing any youngsters. The flexibility’s workers checked and reported two youngsters luxuriate in been missing, the Kearney Hub reports. Early the subsequent day, deputies in neighboring Seward County chanced on an abandoned, stolen automobile in a snowbank off Interstate 80. Footprints within the snow led deputies to the 2 escaped juveniles. By Wednesday afternoon, York County deputies got a fable that a transportation company driver taking the kids aid to the Kearney facility had been assaulted and the transport van stolen. York police tracked the van to Hamilton County, the set apart the kids luxuriate in been as soon as more taken into custody and aid to the childhood heart, which has been tormented by escapes and understaffing in contemporary years.
Usa today Nevada
Las Vegas: Town has opened a new park named for a police officer killed within the line of accountability in 2014. The rather just a few officers and dignitaries who attended the dedication ceremony Friday for Officer Alyn Beck Memorial Park on Friday integrated Gov. Steve Sisolak, Mayor Carolyn Goodman and Clark County Sheriff Joe Lombardo, head of the Las Vegas Metropolitan Police Division. Beck and but another officer luxuriate in been killed whereas having lunch at a cafe as soon as they luxuriate in been shot by a couple who also killed a civilian who tried to forestall them. The couple sooner or later died in a gunfight with other officers. The 10-acre park named after Beck capabilities a lacrosse arena, soccer fields, basketball court and a shadowy playground with benches for families.
Usa today Fresh Hampshire
Hampton Seaside: The village’s annual Easter egg hunt has been moved inland out of concern that plastic eggs might perhaps likely perchance prove within the ocean. The Hampton Seaside Parks & Recreation Division announced on Fb on Wednesday that the department will no longer host the Easter Egg Dig on the seaside because it might perhaps perhaps perhaps not be particular all eggs will seemingly be accounted for, the Portsmouth Herald reports. “I know there’s rather just a few people who be pleased this, and it’s been a practice,” Recreation Director Rene Boudreau stated. “I also feel that it’s a time the set apart these forms of choices must silent be made, and I’d otherwise be recognized for making an strive to aid the trigger as against be fragment of the issues.” The department’s post got blended response. Some of us praised the determination, whereas others referred to because it “very foolish.” But Blue Ocean Society Director Jen Kennedy wrote in a letter to the editor that many eggs which would be no longer chanced on all around the hunt are chanced on in seaside cleanups months later.
Usa today Fresh Jersey
Elmwood Park: A northern Fresh Jersey paper plant is working as soon as more, a 365 days after a massive fire destroyed most of it. Democratic Gov. Phil Murphy was as soon as among the many internet site visitors Friday at the Marcal plant in Elmwood Park for a ceremony at one in every of the few structures that wasn’t leveled by the January 2019 fire. “We must forever receive aid to work,” Marcal CEO Get rid of Baron stated Friday. Marcal’s resumption of operations was as soon as made that that you just might perhaps perhaps imagine through a merger with Lewistown, Pennsylvania-essentially based Nittany Paper Mills. Investigators performed more than 100 interviews and concluded that the fire started in a constructing the set apart massive rolls of paper luxuriate in been saved, however they luxuriate in been unable to determine the trigger because of the huge hurt. The fire destroyed 30 of 36 structures apart from to Marcal’s acquainted crimson label visible from Interstate 80. Demolition at the positioning began remaining August. About 500 people misplaced their jobs.
Usa today Fresh Mexico
Albuquerque: Police employed a convicted felon and allowed him to continue working in a high-ranking space even after officers learned he had equipped a frightful birthdate and Social Security amount, city recordsdata indicate. Paperwork bought by KOAT-TV through an commence recordsdata quiz indicate that Amir Chapel was as soon as employed in April as the department’s policy and compliance supervisor. The space, which paid $72,000 a 365 days, was as soon as created to construct particular police adopted town’s settlement agreement with the U.S. Division of Justice engrossing utilize of excessive pressure. A department memo and court recordsdata indicate Chapel had been convicted of forgery in Texas, misuse of a bank card in Illinois and theft in California. Below Albuquerque personnel suggestions, applicants are ineligible for city employment if they construct a spurious assertion on capabilities or if they luxuriate in a outdated felony conviction engrossing “comely turpitude.”
Usa today Fresh York
Albany: The Fresh York Issue Bar Affiliation is endorsing the legalization of leisure marijuana, as divulge lawmakers preserve in mind proposals this session to legalize the drug. Gov. Andrew Cuomo, a Democrat, has set apart forward guidelines to legalize marijuana within the divulge. Below the governor’s proposal, sales to retail dispensaries would be taxed at 20%, and folks can luxuriate in 1 ounce of marijuana sooner than entering concern. A separate proposal, backed by Democrats within the Legislature, would permit people to need to luxuriate in 3 oz of marijuana. The guidelines would space one in every of the largest limits for comely marijuana possession within the nation. The bar association on Friday announced that it helps legalizing adult leisure marijuana. The association also stated it accredited a fable that outlined completely different recommendations for how the divulge must silent take care of the train.
Usa today North Carolina
Raleigh: From interstate improvements to inform lanes, the divulge’s Division of Transportation is asking residents to inform which initiatives they wish funded over the subsequent 10 years. A statewide public commentary duration to put up suggestions continues through Feb. 28 for the 10-365 days transportation conception for 2023-2032. Residents can ship mission suggestions in a short, interactive perceive chanced on on the 2023-2032 STIP internet internet site. Projects will likely be for any form of transportation, in conjunction with dual carriageway, aviation, bicycle, pedestrian, ferries, rail and public transportation. The commentary duration will not be any longer for maintenance, corresponding to patching potholes. Apart from to, a three-day commence dwelling will seemingly be held Tuesday through Thursday all over regular enterprise hours at DOT’s Division 5 headquarters in Durham for in-particular person enter about doable initiatives in Wake, Durham, Franklin, Particular person, Granville, Vance and Warren counties.
Usa today North Dakota
Bismarck: A pipeline spill of oil-arena wastewater in northwestern North Dakota has affected more cropland than originally reported. Issue environmental scientist Bill Suess stated regulators luxuriate in been notified remaining month of the 8,400-gallon pipeline leak in Renville County. The pipeline is operated by Texas-essentially based Cobra Oil and Gasoline. Regulators initially stated about 1,000 sq. feet of cropland was as soon as affected. The landowner, Sherwood resident Allan Engh, stated people fascinated about the cleanup of the positioning told him the brine can luxuriate in evil as powerful as 400,000 sq. feet of soil. Suess told the Bismarck Tribune that estimate would be simply, however the official amount will not be any longer but recognized. “We perceive it’s larger; we perceive it’s impacting a in point of fact massive dwelling,” Suess stated. He stated the spill of produced water passed off 2 miles north of Sherwood and within a mile of the U.S.-Canada border. The trigger of the pipeline leak is unknown.
Usa today Ohio
Cincinnati: Fiona, the hippopotamus heartthrob at the Cincinnati Zoo & Botanical Backyard, apparently made a mess of her Neat Bowl prediction Thursday. Zookeepers positioned two “enrichment” toys in front of her, marked with the emblems of the Kansas Metropolis Chiefs and the San Francisco 49ers. Whereas the conception referred to as for Fiona to nudge one in every of the items with her snout to show her make a choice, she as a change chose to lose her leafy green lunch on the Chiefs’ item, WLWT-TV reports. Fiona’s untimely beginning three years within the past drew international consideration. She has since grown to 1,200 pounds, roughly the load of four NFL offensive linemen. It’s the third 365 days she has handicapped the Neat Bowl, accurately picking the Philadelphia Eagles to beat the Fresh England Patriots in 2018 however missing on the Los Angeles Rams upsetting the Patriots in 2019.
Usa today Oklahoma
Norman: A reflect has refused to brush apart a lawsuit accusing the University of Oklahoma’s Board of Regents of negligence in its handling of a sexual harassment case. Cleveland County District Mediate Thad Balkman ruled Thursday that the case filed by Levi Hilliard involves a “blended search recordsdata from of law and facts” that need to be decided in future comely proceedings, The Norman Transcript reports. Balkman, on the other hand, did brush apart a fraction of the lawsuit that sought punitive damages against the university. Hilliard, a delicate server at a university restaurant, says gentle OU Vice President Jim “Tripp” Hall III made sexual advances in direction of him on more than one cases. He says Hall “patted him on the buttocks” all around the autumn 2017 semester and pinched his nipples at the university membership the set apart Hilliard labored.
Usa today Oregon
Portland: Town has agreed to pay an African American couple $120,000 to settle a discrimination lawsuit that contended a police officer pulled them over and then broke essentially the major off within the ignition, leaving them stranded. The Oregonian/OregonLive reports city officers settled the suit Friday with Claudius and Daynelle Banks. Officer Christian Berge stated he pulled the couple over in March 2015 at 2 a.m. for drifting into oncoming internet site visitors. Attorneys for the Banks stated Berge never filed a fable or performed a arena sobriety test. Berge stated he didn’t luxuriate in time or backup pork up to course of a drunken using arrest, so he gave the Banks a warning and allowed them to lunge dwelling. Berge stated he accidentally broke essentially the major off no longer within the ignition however within the motive force’s door lock. He denied buying the vehicle. Court docket paperwork state Berge had approached the vehicle and ordered, “Collect your murky (expletive) out of the auto.”
Usa today Pennsylvania
Harrisburg: A reflect set apart a freeze on a new divulge police policy referring to sales of partially manufactured gun frames that will likely be made into working pistols and rifles. Commonwealth Court docket Mediate Kevin Brobson issued the preliminary injunction Friday, about three weeks after divulge police equipped steering to gun dealers about be taught how to set apart background checks for sales of what are on occasion referred to as 80% receivers or unassembled “ghost weapons.” Brobson stated the plaintiffs, agencies that create and promote the gun frames, luxuriate in raised a proper search recordsdata from about whether the divulge police policy is simply too vague. He stated he would be commence to revisiting the scope of his injunction, reckoning on what divulge police does in response. Issue police announced remaining month that gun dealers need to name the divulge gun-utilize background test device for sales of the 80% receivers and are no longer accredited to easily utilize the online device.
Usa today Rhode Island
Windfall: A invoice would require safety limitations or netting on bridges that join islands to the divulge’s mainland. If made into law, the constraints would be required for 3 bridges that join Aquidneck and Conanicut islands to the Rhode Island mainland – Mount Hope Bridge, the Claiborne Pell Bridge and the Jamestown Verrazzano Bridge – by Jan. 1, 2022, to be succesful to forestall suicides. Gain. Joseph J. Solomon Jr., D-Warwick, launched the guidelines. He described the priority as “frequent” and stated in a assertion that Portsmouth Police replied to Mount Hope Bridge 36 cases remaining 365 days. Between 2010 and 2018, there luxuriate in been 27 suicide deaths from the three bridges, essentially based on the Rhode Island Division of Health. The Rhode Island Turnpike and Bridge Authority already has prevention measures in region, in conjunction with a surveillance device that permits authorities to act quick.
Usa today South Carolina
Columbia: The divulge’s military museum covers 250 years of artifacts and tales of daring troopers battling for their nation, from the Modern War to the continuing warfare Afghanistan. But the museum’s official name – the South Carolina Accomplice Relic Room and Militia Museum – is stuck within the four years South Carolinians didn’t warfare for the U.S. And when anything else engrossing the Confederacy comes up, it drags on fundraising and admissions, Govt Director Allen Roberson says. When honest no longer too long within the past working on renewing its national accreditation, the American Alliance of Museums Accreditation stated the museum might perhaps likely perchance construct it more uncomplicated on itself by eradicating “Accomplice” from its name. Roberson has his luxuriate in trigger of suggesting the replace. “The name correct now is simply too long. And what ruin you specialize in about must you hear ‘relic’? I utilize ‘artifacts,’ ” he says, suggesting a relic would be a exiguous bottle of sand from a desolate tract warfare, whereas an artifact might perhaps be the pen a president worn to label a declaration of war.
Usa today South Dakota
Expeditiously Metropolis: Tribal police luxuriate in taken over law enforcement duties from the Bureau of Indian Affairs on the Pine Ridge Reservation. Tribal Police Chief Robert Ecoffey told the Expeditiously Metropolis Journal stated the tribe wasn’t getting “ample sources by manner of manpower” from the BIA. The switch is allowed below the 1975 Indian Self Option and Training Support Act, which permits tribes to preserve an eye fixed on federal programs that affect their communities. Charles Addington, director of the BIA’s Place of job of Justice Companies and products, stated the company helps the switch. Tribal officers will take preserve an eye fixed on of the BIA’s $1.3 million funds, property, equipment and responsibilities, which embody investigating larger-stage crimes on the reservation, Addington stated. Ecoffey stated the BIA allocates 9 positions to the reservation, and 9 of his officers luxuriate in now been promoted to detective.
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Nashville: The divulge’s Division of Ambiance and Conservation on Thursday announced that Dunbar Cave Issue Park has been selected as the 2019 Tennessee Issue Park of the 365 days. The company says Dunbar Cave Issue Park – which encompasses 144 acres – is the positioning of mighty prehistoric Mississippian Native American cave art, apart from to a prehistoric space for fragment of the Eastern Woodlands. At some level of the final two years, the workers has remodeled Dunbar Cave Issue Park by redeveloping cave tours to be more participating. Research performed by park staffers resulted in new discoveries of Mississippian art and uncommon Cherokee written symbols that signify syllables. “Dunbar Cave Issue Park represents just among the supreme qualities of our divulge parks device,” Deputy Commissioner Jim Bryson says. “It takes plenty to stand out among the many work of our 56 divulge parks, and we're happy with the work that has been performed at Dunbar Cave.”
Usa today Texas
Dallas: Better than a dozen police officers luxuriate in been disciplined for making offensive statements on social media, in conjunction with posts that luxuriate in been bigoted or made gentle of police violence. Town’s police department announced Thursday that 13 officers whose posts violated department policy would get punishments ranging from a written reprimand to unpaid suspension. Two more cases are silent being reviewed, and one officer resigned, the department stated in a assertion and memo on the disciplinary measures. The officers can attraction their punishments. “It's miles crucial that we operate with the supreme stage of ethics and integrity to construct particular the final public is confident within the legitimacy of who we're as a law enforcement company,” Dallas Police Chief U. Renee Hall stated. The officer’s posts luxuriate in been among hundreds identified by researchers with the Uncomplicated Leer Mission as doubtlessly undermining public self assurance in police departments round the nation.
Usa today Utah
Brigham Metropolis: A 9-365 days-extinct boy is in real situation after accidentally taking pictures himself within the head, authorities state. Brigham Metropolis Police Division replied to the name Thursday correct after 5 p.m., authorities stated. The boy was as soon as taken to Brigham Metropolis Team Health heart however was as soon as later transferred to Most critical Kids’s Health heart in Salt Lake Metropolis, authorities stated. An investigation is ongoing. The accidental taking pictures took place correct hours after a 3-365 days-extinct boy accidentally shot himself within the head whereas fiddling with a gun in his dwelling in Murray, about 65 miles south of Brigham Metropolis, authorities state. Police believe the three-365 days-extinct boy was as soon as wide awake sooner than his of us and but another sibling and worn a chair to achieve a handgun that was as soon as sitting on a kitchen cupboard, officer Kenny Bass told the Deseret Recordsdata.
Usa today Vermont
Montpelier: Republican Gov. Phil Scott has vetoed a paid family and medical wander away invoice, saying it might perhaps perhaps perhaps likely perchance luxuriate in worsened economic disagreement within the divulge. Scott stated Friday that he'll switch forward with a voluntary program that doesn’t rely upon a indispensable $29 million payroll tax. “For years, Vermonters luxuriate in made it decided they don’t favor, nor can they arrive up with the cash for, new tall-essentially based taxes,” he stated in a assertion. “We won't continue to construct the divulge less affordable for working Vermonters and more complex for employers to make utilize of them – even for successfully-intentioned programs be pleased this one.” Democratic legislative leaders expressed disappointment about the veto. Home Speaker Mitzi Johnson stated the invoice represented indispensable circulation in direction of Scott’s space, however the governor was as soon as unwilling to compromise.
Usa today Virginia
Tazewell: A rescued pet helps lighten the stressful days of the dispatchers at a 911 heart. The pet’s gentle householders surrendered the 8-week-extinct lab mix to the Tazewell County Sheriff’s Place of job, and dispatchers fell in be pleased, WVNS-TV reports. “A form of people don’t imprint how stressful this job will likely be,” Edwinna Cecil told the arrangement. “If we now luxuriate in a unpleasant name, which you might perhaps perhaps’t be upset must you gawk one thing this treasured. It helps silent all people down. Your entire atmosphere has changed since he’s been right here.” As the official 911 dispatcher carrier canine, he'll no longer most productive provide emotional pork up however even be an ambassador for 911, attending events and visiting colleges. Dispatchers are asking the final public to aid name the pet. Folks can vote on the sheriff’s region of job Fb internet page for their favourite or four proposed names – Mischief, Rookie, Taser or Creed. Votes will seemingly be counted Monday afternoon.
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Richland: Power Northwest is brooding about whether there might perhaps be a necessity and regional interest for adding a exiguous modular nuclear reactor device strategy the Tri-Cities – Kennewick, Pasco and Richland. Power Northwest already operates the supreme commercial nuclear vitality reactor within the Northwest, Columbia Generating Set strategy Richland, apart from to exiguous explain voltaic and hydroelectric initiatives and a wind farm. The public company for the time being generates the electrical energy for more than 1.5 million customers in Washington divulge. Now it plans to use up to $2 million to sight at the feasibility of exiguous modular reactors that can likely perchance very successfully be added strategy its existing reactor. The ogle will sight at the electrical energy that will seemingly be wanted within the Northwest in coming decades and the set apart this is in a position to likely come from.
Usa today West Virginia
Charleston: The divulge might perhaps likely perchance soon require the like a flash checking out and series of rape kits below a invoice passed by the Home of Delegates on Friday. Lawmakers accredited the proposal by a unanimous vote of 96-0 without debate. It now strikes to the Senate for consideration. The invoice comes amid a national push to decided backlogs of the kits. Better than 20 states luxuriate in accredited payments to require submission tricks or equipment audits within the past two years, essentially based on the advocacy community Halt The Backlog. The measure would require the kits to be submitted to the divulge police’s forensic lab within 30 days or as soon as that that you just might perhaps perhaps imagine after series. It can likely also allow for the advent of a monitoring course of of the kits and would require a court expose sooner than law enforcement might perhaps likely perchance put off the examinations.
Usa today Wisconsin
Milwaukee: Town’s first brewery since Prohibition, Sprecher Brewing, was as soon as sold Friday to a community of native merchants. Sprecher Brewing is credited with soar-beginning the craft beer age in Milwaukee when Randy Sprecher and enterprise accomplice James Bubolz opened shop in 1985, with $40,000 and a hand-built brew kettle. Sprecher Brewing is metro Milwaukee’s longest-working craft brewery. Sharad Chadha, gentle vp for GE Clinical and an executive with Samsung, might perhaps be the brewery’s CEO. Milwaukee native and entrepreneur Andy Nunemaker will seemingly be chairman of the board, and Jim Kanter, the gentle usual supervisor for MilllerCoors, will even be on the leadership crew. “Nothing is truly going to replace for our partners and suppliers and things be pleased that,” brewery president Jeff Hamilton stated Friday. Chadha stated the aim is to construct Sprecher a national craft beverage producer.
Usa today Wyoming
Casper: The headdress worn by a Native chief is returning to the tribe after he gave it to a non-Native dentist residing within the divulge, tribal leaders stated. The Northern Arapaho Tribe held a ceremony Saturday to welcome the headdress of Chief Murky Coal, who guided many to the Wind River Reservation in Wyoming within the 19th century, the Casper Huge name-Tribune reports. Coal gave his headdress to a dentist who would gradually lunge to the reservation to provide dental care, officers stated. The abundant-grandson of that dentist contacted the tribe remaining 365 days asking if the tribe wanted the headdress aid, tribal leaders stated. The Tribal Ancient Preservation region of job popular the offer, and descendants of Coal traveled to Massachusetts to retrieve the 140-365 days-extinct headdress, officers stated.
From USA TODAY Network and wire reports
Read or Fragment this story: https://www.usatoday.com/story/recordsdata/50-states/2020/02/03/tibetan-monks-turtle-free up-pet-rescue-recordsdata-round-states/41132187/
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SF Startup Microdrop Revisits Blood-Test Tech in Wake of Theranos Debacle – CBS San Francisco
SAN FRANCISCO (KPIX) — A well being care startup referred to as Microdrop is bringing the lab to your own home. Co-founder Jani Tuomi says blood amassed in a small vial guarantees to provide check effects which can be as dependable as conventional lab trying out ones. Microdrop’s at-home blood trying out equipment is known as imaware. The corporate is operating with docs in California to increase new checks to assist shoppers get forward of a possible illness. “That first visit to the doctor is actually very time consuming, tactical, paper oriented, just to order a test,” stated Tuomi. “So what we’re saying is, let’s not necessarily waste time on that first visit, and let’s have you go armed with a little more information.” Information would come from the Imaware equipment, to be had on-line for $99. The international blood trying out marketplace is anticipated to succeed in $60 billion greenbacks through 2023. It’s an area made murky through Elizabeth Holmes, founder of Theranos. She had promised to revolutionize blood trying out the usage of a identical approach of assortment. She is now watching for trial on fees of fraud and legal conspiracy for deceptive buyers about its era. “The problem was that they had technologies that were not validated in a clinical environment and they did not engage the clinical lab professionals when they first launched,” stated Dr. Alan Wu, professor of laboratory drugs at UCSF. Microdrop says it’s devoted to accuracy and transparency in how its checks paintings. The vials are despatched to qualified spouse labs across the nation. No lab order is needed, the method takes lower than five mins and, after mailing again the vial, effects are to be had inside of 5 days. Currently, imaware best monitors for Celiac illness and rheumatoid arthritis however it plans to make bigger its vary in the approaching months to incorporate checks for center illness and different auto-immune prerequisites. Tuomi says the objective is to assist other folks get identified sooner. “Where we want to go to is proactive healthcare,” stated Tuomi. “Proactive healthcare means being able to measure and monitor your health stats and vitals and, when you see something going out of range, you go to your doctor proactively.” Dr. Wu, who isn’t affiliated with the startup, says Microdrop presentations promise, because the at-home trying out business grows. One of its key advisers, Dr. Eleftherios Diamandis, was once an early critic of Theranos. A credible medical magazine, CCLM, has additionally validated effects from the Celiac check. “We don’t want patients making their own diagnoses, ordering their own laboratory tests and interpreting laboratory results, without the help of a professional. So, bypassing that step is potentially problematic,” Dr. Wu cautioned. Tuomi says he believes the imaware equipment will upload efficacy to the method. “We don’t want you to not visit your doctor, we just want you to visit your doctor with a little more awareness of your health and the words that resonate with them,” stated Tuomi. WEBLINKS: imaware – http://imaware.health Microdrop – http://microdrop.health
from Moose Gazette https://ift.tt/2zGpef3 via moosegazette.net
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Elroy Air’s autonomous aircraft can carry over 250 pounds of cargo
Elroy Air, a San Francisco startup developing delivery drones for large commercial payloads, today announced a milestone toward its goal of commercializing its aircraft by 2021. The company says that in partnership with the Naval Postgraduate School on August 14, it completed a test of an over 1,250-pound prototype drone — the Chaparral — it claims will carry more than 250 pounds of cargo at 100 miles per hour over a 300-mile range.
Much like the company’s full-scale Aluminum Falcon prototype, the Chaparral is equipped with a bevy of sensors, including lidar, cameras, and radar, along with an onboard computer running air-traffic management software. It sports a hybrid gas-electric powertrain that Elroy claims emits fewer pollutants than conventional engines and which doesn’t rely on any sort of battery-charge infrastructure, plus propellers and wings that carry it in flight.
“Today is an important step toward the future of logistics,” said CEO and cofounder David Merrill. “Since the earliest days of powered flight people have wanted to use the skies for convenient, rapid cargo transport to anywhere. The airport-dependence of traditional manned air cargo options shows that we still have a long way to go. Autonomous [vertical takeoff and landing] cargo systems will make the dream of ultra-responsive logistics possible, because they decouple air cargo from airports.”
The Chaparral can carry between 200 and 500 pounds of cargo — a lot of weight for aircraft with a 300-mile range. Fortunately, humans aren’t tasked with the heavy lifting. Elroy’s self-guided cargo-handling machine spots a ground navigation system that can load and unload packages all by itself, thanks to aerodynamic modular cargo pods that automatically lower to the ground and release post-landing.
It’s worth pointing out that Elroy’s drones haven’t fulfilled any deliveries just yet. During the aforementioned test, the prototype, which was remotely controlled by a test pilot, reached a maximum height of ten feet and hovered for just 64 seconds before descending and landing. But former Airwave product manager and Elroy vice president of engineering Clint Cope asserts that it lays the groundwork for more sophisticated flights in the near future.
“Developing a robust … system at this scale of payload is a challenging feat that requires the right team and resources,” explained Cope. “The set of flight-critical systems that all have to be working perfectly together for robust, repeatable performance is non-trivial … [and this flight] validates what our team can do.”
Elroy was cofounded almost three years ago by Cope and Merrill, and it operated largely under the radar before emerging from stealth with a prototype drone that could carry hundreds of pounds of cargo over hundreds of miles. In February 2019, it announced that it had raised $9.2 million in seed funding, preceding the launch of pilot programs with a small number of shippers in select locations in 2020. By the tail end of that timeframe, Elroy says, it expects to achieve “24/7” delivery capabilities.
Elroy envisions its drones someday delivering not only goods to customers in remote places and traffic-choked urban centers, but care packages and medical supplies to victims of natural and manmade disasters. To this end, Elroy says that unnamed humanitarian aid organizations have expressed interest in its vehicles for food, supplement, water, and medical supply delivery.
Regulatory hurdles stand in the way. In order to comply with the U.S. Federal Aviation Administration’s (FAA) Rule 107, which prohibits the use of commercial drones within 500 feet of “non-participating” people and structures, most delivery drones in the U.S. have to remain within line of sight and fly routes without people below.
Indirect Elroy rivals such as UPS’ newly formed Flight Forward subsidiary and Alphabet X lab graduate Wing work around the strictures by securing Part 135 approval, which permits them to conduct FAA-certified flight operations beyond line of sight, at night, and without limit to the number of drones or operators in command. It confers a small-sized air carrier designation, affording more leeway in fleet management and paving the way for service in towns like Blacksburg, Virginia.
Assuming Elroy pursues the same path, it’ll have to contend with fierce competition in the estimated $91.5 billion autonomous last-mile delivery market. UPS, FedEx, Flirtey, Zipline, Flytrex, and Alibaba’s Ele.me are already staking claims, to say nothing of Amazon’s forthcoming Prime Air drone service. Separately, Uber recently announced plans to deliver food by drone in San Diego.
If any company is up to the challenge, though, it’s Elroy. Merrill worked with Cope at 3D Robotics, which acquired Merrill’s intelligent toy maker Sifteo in 2014, and Elroy counts among its team engineers from the Massachusetts Institute of Technology, Georgia Tech, Stanford, Rice, and Embry-Riddle Aeronautical University, as well as Uber Freight, Airware, Honeywell, and other companies in aerospace, UAVs, industrial design, supply chain, and robotics. As for its backers, they include Catapult Ventures, Levitate Capital, Lemnos, Precursor Ventures, Haystack, Shasta Ventures, TenOneTen, Amplify Partners, Homebrew, Hemisphere Ventures, Diamondstream Partners, E14 Fund, City Light, Side X Side Management, Venture Investment Associates, 122 West, S7 Ventures, and angel investors.
“These large cargo systems are about to become mainstream, and the Elroy Air team is leading the industry with our development of the Chaparral aerial cargo system,” said Merrill.
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Lab Equipment for Regulated Industries: Qualification and Validation
Regardless of your company’s industry, lab equipment validation in San Francisco is required to ensure tests and experiments are accurate and consistent. This article looks at best practices, why validation is important, and more. But first, what is lab validation?
What Is Lab Equipment Validation?
Lab equipment validation is the process of verifying that a piece of laboratory equipment is performing according to its intended specifications and is suitable for its intended use. This process is important because it ensures that the results produced by the equipment are accurate, reliable, and consistent.
Steps for Lab Equipment Qualification and Validation
There are several steps involved in lab equipment validation, including:
Defining the Intended Use of the Equipment
Defining the intended use of a piece of lab equipment involves identifying the specific types of measurements or experiments that the equipment will be used for, as well as the range of operating conditions under which it will be used.
This information is important because it helps to determine the performance specifications for the equipment and the testing methods that will be used to validate it.
Some factors to consider when defining equipment use include sample types, operating conditions, types of experiments, and user requirements.
Establish Performance Specifications
Establishing performance specifications for a piece of lab equipment involves identifying the acceptable range of performance for the equipment based on its intended use and the requirements of the specific application.
This information is important because it helps to determine the testing methods that will be used to validate the equipment and the criteria that will be used to assess its performance.
Some aspects to consider when establishing performance specifications include user requirements, regulatory and industry standards, intended use, and manufacturer’s specifications.
Test the Equipment
This involves using various methods, such as standard test procedures or customized testing protocols, to evaluate the performance of the equipment. This may include verifying that the equipment is accurate, precise, and repeatable, as well as testing its stability, linearity, and sensitivity.
Methods used to test lab equipment include the following:
Standard test procedures: Many regulatory agencies and industry organizations in San Francisco have established standard test procedures for evaluating the performance of specific types of lab equipment. These procedures may include tests for accuracy, precision, linearity, stability, and other characteristics.
Customized testing protocols: In some cases, it may be necessary to develop customized testing protocols to evaluate the performance of the equipment. These protocols may be based on the intended use of the equipment, the user requirements, or the specific characteristics of the samples being analyzed.
Verification using reference materials: One way to test the accuracy of a piece of lab equipment is to use reference materials or standards that are known to have a specific value. By comparing the results obtained using the equipment to the known value of the reference material, it is possible to assess the accuracy of the equipment.
Validation using real samples: Another way to test the performance of a lab equipment is to use real samples that are representative of the types of samples that the equipment will be used to analyze or test. By comparing the results obtained using the equipment to known values or accepted standards, it is possible to assess the accuracy and reliability of the equipment.
Document the Results
It is creating a validation report that summarizes the testing results and demonstrates that the equipment is suitable for its intended use. The report should include details on the testing methods used, the results obtained, and any discrepancies or deviations from the performance specifications.
Review and Approve the Validation
The validation report should be reviewed and approved by a qualified individual, such as a laboratory manager or quality assurance specialist, to ensure that it meets all relevant regulatory and industry standards. Biotech Services, Inc. offers lab equipment validation in San Francisco. If you need this service, feel free to contact us.
Maintain the Equipment
Once the equipment has been validated, it is important to maintain it in good working condition to ensure that it continues to meet the performance specifications.
This may involve performing periodic calibration and maintenance, as well as documenting any changes or repairs made to the equipment.
Here are best lab equipment maintenance practices
Follow the manufacturer’s recommendations: Most lab equipment come with a user manual that includes information on how to care for and maintain the equipment. It is important to follow these recommendations to ensure that the equipment is used and maintained properly.
Perform periodic calibration: Calibration is the process of adjusting the equipment to ensure that it is accurate and precise. It is important to calibrate lab equipment according to the manufacturer’s recommendations and any relevant regulatory or industry standards.
Clean and store equipment properly: Proper cleaning and storage of lab equipment can help to extend its lifespan and ensure that it continues to perform well. This may involve cleaning the equipment after use, storing it in a clean and dry environment, and protecting it from physical damage.
Keep accurate maintenance records: It is important to keep accurate records of all maintenance activities, including calibration, repairs, and any other work performed on the equipment. This information can be used to identify any potential problems with the equipment and to schedule future maintenance.
Follow safety procedures: It is important to follow all safety procedures when using and maintaining lab equipment to protect yourself and others from potential hazards. This may include wearing appropriate personal protective equipment, following proper handling procedures, and following all warning labels and instructions.
Lab equipment validation is an important part of quality control in the laboratory and is typically required by regulatory agencies and industry standards.
It helps to ensure that the results produced by the equipment are accurate and reliable, which is essential for making informed decisions and producing high-quality products or services.
Benefits for Lab Equipment Qualification and Validation
There are several benefits to validating lab equipment, including:
Improved Accuracy and Reliability of Results
By ensuring that the equipment is performing according to its intended specifications, validation helps to ensure that the results produced by the equipment are accurate and reliable. This is essential for making informed decisions and producing high-quality products or services.
Compliance With Regulatory and Industry Standards
Many regulatory agencies and industry organizations require lab equipment to be validated to ensure that it meets certain performance standards. Validation helps to ensure that the equipment is compliant with these standards and can be used in regulated environments.
Increased Confidence in the Equipment
By demonstrating that the equipment is suitable for its intended use, validation helps to increase confidence in the results produced by the equipment. This is particularly important in scientific research, where the accuracy and reliability of the results are critical.
Improved Efficiency and Productivity
Validated equipment that is performing according to its intended specifications is likely to be more efficient and productive than equipment that is not properly validated. This can help to reduce the time and resources needed to complete experiments and analyses.
Reduced Risk of Errors and Rework
By ensuring that the equipment is accurate and reliable, validation helps to reduce the risk of errors and the need for rework. This can help to save time and resources and improve the overall quality of the work being performed.
Why Do You Need To Work With a Lab Equipment Validation Company
There are several reasons why it may be beneficial to work with a validation company to validate your lab equipment:
Expertise and Experience
Validation companies typically have a team of experts who are trained and experienced in evaluating the performance of lab equipment. They can provide valuable insights and guidance on the best methods for validating the equipment and ensure that the validation process is conducted according to relevant regulatory and industry standards.
Objectivity and Impartiality
Working with a validation company can help to ensure that the validation process is objective and impartial. This is important because it helps to ensure that the results of the validation are unbiased and that the equipment is being evaluated based on its intended use and performance specifications, rather than any personal or organizational bias.
Time and Resource Savings
Validation can be a complex and time-consuming process, especially if you are not familiar with the relevant standards and procedures. Working with a validation company can help to save time and resources by allowing you to focus on your core business while the validation experts handle the details of the process.
Independent Verification
By working with a validation company, you can obtain an independent verification of the performance of your lab equipment. This can help to increase confidence in the equipment and the results it produces, which is particularly important in regulated environments or when working with external clients or partners.
Overall, working with a validation company can provide a number of benefits when it comes to validating your lab equipment. It can help to ensure that the process is conducted efficiently and effectively, and that the results are accurate and reliable.
Conclusion
As you can see lab equipment validation and qualification enables you to achieve accurate and reliable test results. We recommend consulting companies offering lab equipment validation in San Francisco such as Biotechnical Services, Inc. for optimal results.
Original Source: https://www.biotechserv.com/lab-equipment-for-regulated-industries-qualification-and-validation/
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Scaling Up Science During a Global-Scale Emergency
vimeo
Showing an inspiring knack for innovation under pressure, the global scientific community has developed promising tests and treatments for COVID-19 in the span of just a few months. But moving medical technologies from conception to deployment at such an unprecedented rate comes with a multitude of hurdles, one of which is the obvious challenge of scale. How do companies turn a handful of prototypes or a few flasks of drug-secreting cells into a mass-produced product ready for market?
This is the primary focus for process engineer scientists at the Advanced Biofuels and Bioproducts Process Development Unit (ABPDU) at Lawrence Berkeley National Laboratory (Berkeley Lab). The ABPDU was founded to serve as a resource of equipment and expertise for companies or institutions that are using biological processes to generate exciting and potentially revolutionary products. Since opening their doors in 2012, the unit has collaborated with more than 62 groups to accelerate the development of sustainable biofuels, smart materials, innovative foods, and next-generation medicines.
Eager to apply their biomanufacturing know-how to the current crisis, ABPDU teams have been working during the shelter-in-place orders to help two companies scale-up production of new technologies that could aid in ending the pandemic.
Rapid, portable test kits using CRISPR
Although diagnostic testing for COVID-19 is becoming increasingly accessible, the test kits currently in use at hospitals, clinics, and walk-in centers around the world have many limitations. To detect the presence of coronavirus (SARS-CoV-2) from nasal and throat swabs, most of these kits have to be analyzed in centralized laboratories, with trained personnel and sophisticated equipment. Hoping to shift the paradigm, Argentina-based startup Caspr Biotech is developing a streamlined testing approach based on the increasingly powerful CRISPR gene editing system.
Laura Fernandez works on the 250 mL automated, high throughput bioreactor platform as part of the Caspr Biotech project at the ABPDU. (Credit: Marilyn Sargent/Berkeley Lab)
“The company has recently shown how well their system works, and its potential is pretty big,” said project lead and ABPDU principal investigator Eric Sundstrom. “The limiting factor for them at this time is the production of the CRISPR Cas-12 enzyme system. Our role here is to work in parallel with them and design an approach for scaled-up production of the protein, so that they have enough for more widespread clinical testing. Then, hopefully, we can help transfer the technology to a manufacturer who can produce it at the commercial scale.”
Like many biological products and medicines, Caspr’s proprietary Cas-12 enzyme is produced by specially engineered microbes through fermentation. The enzyme works as a detection system because it binds to a specific sequence of DNA – in this case it is engineered to target part of the SARS-CoV-2 genome – and then chops the DNA at that location. After cleaving the viral DNA, the Cas-12 enzyme will start to indiscriminately chop up any DNA that it encounters, so each test kit contains special DNA fragments that are bound with fluorescent proteins. This way, if the Cas-12 enzymes encounter the target viral DNA sequence in the blood sample added to the kit, the fluorescent molecules will be freed, and therefore activated, producing a light-based signal that indicates the individual is positive for a COVID-19 infection.
The company’s CRISPR Cas-12 enzyme is capable of seeking out very low levels of coronavirus DNA and has negligible rates of binding to other DNA sequences, according to as-of-yet unpublished evaluations of the system using samples collected from COVID-19 patients in the U.S. and other countries. These properties make the test highly sensitive and specific; meaning that the test results should have very few false negatives and no false positives. Furthermore, the kit analyzing equipment is small, portable, and can process a sample in less than 40 minutes. Current tests take several hours.
When Caspr approached the ABPDU for scale-up help in early April, they were already in the midst of validation testing (a step necessary for approval by regulatory agencies such as the Food and Drug Administration [FDA]) yet were only able to produce tiny batches of their enzyme at a time. “The company was at the smallest scale when they came to ABPDU, so working on this project has been an excellent opportunity for our team to rapidly dissect a challenge and build new processes,” said Laura Fernandez, a Berkeley Lab process engineer at the ABPDU.
Fernandez and senior process engineer Jan-Philip Prahl first scaled Caspr’s fermentation process up to their highly automated 250-milliliter bioreactor system, then successfully designed a fermentation protocol for 10-liter bioreactors. The insights generated by the 10-liter run will allow the company to further scale to commercial volumes, which are typically hundreds or thousands of liters. Two other team members are now developing a process for purifying the protein from the other molecules made by the fermenting microbes.
“We found that ABPDU is the ideal partner for the optimization of the fermentation at the initial scale of 10 liters and for helping us with the tech transfer process to larger industrial players to continue the production,” said Caspr co-founder and CEO Franco Goytia. “We are submitting to the FDA for Emergency Use Authorization in the next few weeks, while in parallel scaling up our production capacity to hopefully make our solution widely available in the U.S. and the rest of the world in the second half of 2020.”
A faster approach for antibody production
The co-founder and CEO of Swiftscale Biologics, a San Francisco-based startup, reached out to the ABPDU in early March for help scaling up their rapid neutralizing antibody development and manufacturing platform. Neutralizing antibodies are proteins produced by immune cells that allow the body to detect and combat pathogens. They work by binding to specific features on the outside of virus particles, thereby inhibiting the virus’ ability to infect cells or tagging it for destruction by specialized engulfing immune cells.
Antibody infusions – of either survivor-donated blood plasma or antibodies produced through biomanufacturing – are frequently used to treat infectious diseases in cases where the patient’s immune system is struggling, and evidence from across the world shows that donated plasma is currently the most effective treatment for COVID-19. But unfortunately, there is not nearly enough donated plasma to treat all patients in need, and lab-grown copies of SARS-CoV-2 antibodies are still being developed and tested in clinical trials.
Ethan Oksen (left) and Jan-Philip Prahl (right) set up the disc stack centrifuge as they work on the Swiftscale antibody platform. (Credit: Marilyn Sargent/Berkeley Lab)
“Traditional manufacturing processes for biologics are too time-consuming to meet the needs of the current outbreak,” said Swiftscale CEO David Mace. “To meet this urgent need, Swiftscale is building a platform that can produce these life-saving therapies in a fraction of that time. We can then leverage this platform to accelerate the work of our partners who are developing promising biologics.”
Akash Narani, principal process engineer at ABPDU and lead on the team collaborating with Swiftscale, explained that the company is using a “cell-free” approach that expedites the screening and development of antibodies and then leverages specially engineered microbes that can produce active therapeutic antibodies with previously unachievable productivity. This approach is less costly and time-consuming to develop and scale compared with the standard way to produce antibodies for human medicines and diagnostics, which relies on cultured mammalian cells.
“Swiftscale is envisioning a new way to develop and manufacture biologics. Cell-free technology is still relatively new, but if done right, they can lead to rapid prototyping [identification of the most effective antibodies] and rapid production,” said Narani.
Asun Oka (right) and Chang Dou work on the floor centrifuge for the Swiftscale Biologics collaboration. (Credit: Marilyn Sargent/Berkeley Lab)
Narani and his colleagues began hands-on work at the ABPDU on May 18. Their role is to design and test an efficient process to take Swiftscale’s 250-mililiter fermentations, performed in collaboration with Culture Biosciences, up to 300 liters – a 1,000-fold increase in production volume. Adding to the challenge, the company is still continually optimizing the parts of the production process that come before and after the fermentation stage.
“The scale-up production is a crucial step in the research process and I’m glad we could contribute to such important work and that our efforts are helping research to move quickly,” said Carolina Araujo-Barcelos, an ABPDU fermentation researcher.
Ethan Oksen, a senior research associate, added: “We hope that Swiftscale can apply the insights and data we generated to move quickly to production scale, where they can generate neutralizing antibodies for clinical trials.”
This work also included the efforts of Berkeley Lab researchers Gregory Bontemps, Shawn Chang, Chang Dou, Asun Oka, Isaac Wolf, and Jipeng Yan. The COVID-19 research performed at the ABPDU is supported by Caspr Biotech and Swiftscale Biologics. ABPDU is funded by the Department of Energy’s Bioenergy Technologies Office (BETO).
source https://scienceblog.com/517296/scaling-up-science-during-a-global-scale-emergency/
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On-Call Entry Level Clinical Lab Scientist/Clinical Lab Scientist/Sr. Clinical Lab Scientist
Description:Clinical Laboratory Scientist, (includes CLS Sr., CLS, and Entry Level CLS)Under the general direction of the Laboratory Director, or their designee, performs pre-analytical, analytical and post-analytical procedures and analyses to provide data for health maintenance, diagnoses, treatment and monitoring of medical conditions. Enhances quality of patient care and service through interdepartmental cooperation and quality assurance protocols.Essential Functions:* Correctly verifies that the proper specimen is being analyzed for the correct patients and that the correct test is being performed.* Judges the adequacy and qualities of specimens submitted for testing.* Analyzes clinical laboratory specimens following the standard methods and procedures approved by the Laboratory Director or designee.* Performs quality control procedures to ensure accuracy of clinical data.* Utilizes test reference ranges (including neonates, pediatric and adult) to determine reasonableness of test results.* Validates test results through correlation with test parameters (e.g. Hgb/Hct, anion gap, platelet count/smear, dipstick/micro etc.)* Confirms testing on all Critical Values to ensure accuracy prior to releasing of test results.* Performs routine preventative maintenance and troubleshooting on assigned instruments and equipment according to established schedule and procedure.* Performs and documents instrument function by checking and calibrating specific lab instruments and documents data.* Records on instrument logs any repairs, replacement, and maintenance needed of equipment.* Releases or reports results per Laboratory Standard Operating Procedures.* Trains laboratory assistants on proper techniques/procedures related to clinical laboratory practice.* Performs other related duties as necessary.Additional Duties and Responsibilities:* Clinical Laboratory Scientist, Entry Level – Provides general or direct supervision of Lab Assistants and general Clerical Personnel as required according to lab law and regulations.* Clinical Laboratory Scientist – Provides general or direct supervision of Lab Assistants and general Clerical Personnel as required according to lab law and regulations.* Clinical Laboratory Scientist, Sr. – Trains laboratory assistants, and other Clinical Laboratory Scientists, on proper techniques/procedures related to clinical laboratory practice. Assist with Quality Assurance and Performance Improvement activities consistent with the Laboratory Quality Plan. Provides general or direct supervision of Lab Assistants and general Clerical Personnel as required according to lab law and regulations.Basic Qualifications:* Sr. CLS minimum 3 years of experience, CLS minimum 6 months of experience, Entry Level CLS = none.* Bachelor’s degree in Clinical Lab Sciences or related field. Applicable military experience may be substituted for bachelor’s degree.* Current California State Clinical Laboratory Scientist License/Valid Temporary California State Clinical Laboratory Scientist License for entry level CLS.* Computer application experience/proficiency preferred.* Ability to read and comprehend complex instructions, short correspondence, and memos. Ability to write simple correspondence.* Ability to effectively present information in one-on-one and small group situations to customers, clients, and other incumbents of the organization.* Must be willing to work in a Labor Management Partnership environment.* Also refer to Position Specifications outlined in the appropriate collective bargaining agreement.Permanente is proud to be an equalopportunity/affirmative action employer. This position supports KaiserPermanente’s code of conduct and compliance by adhering to all laws andregulations, accreditation and licensure requirements, and internal policiesand procedures. Kaiser Permanente isproud to be an equal opportunity/affirmative action employer.Primary Location: California,Berkeley,Berkeley Regional Lab – 1701 1701 Eastshore Scheduled Weekly Hours: 0 Shift: Day Workdays: On-Call Working Hours Start: 7:00 AM Working Hours End: 3:30 PM Job Schedule: Call-in/On-Call Job Type: Standard Employee Status: Regular Employee Group/Union Affiliation: ESC/IFPTE – Local 20 – Clinical Lab Scientists Job Level: Individual Contributor Job Category: Laboratory Department: Mycology, AFB and Parasirology Travel: No Kaiser Permanente is an equal opportunity employer committed to a diverse and inclusive workforce. Applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy), age, sexual orientation, national origin, marital status, parental status, ancestry, disability, gender identity, veteran status, genetic information, other distinguishing characteristics of diversity and inclusion, or any other protected status.External hires must pass a background check/drug screen. Qualified applicants with arrest and/or conviction records will be considered for employment in a manner consistent with federal and state laws, as well as applicable local ordinances, including but not limited to the San Francisco and Los Angeles Fair Chance Ordinances.Click here for additional requirements >
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All the companies from Y Combinator’s W20 Demo Day, Part III: Hardware, Robots, AI and Developer Tools
New Post has been published on https://magzoso.com/tech/all-the-companies-from-y-combinators-w20-demo-day-part-iii-hardware-robots-ai-and-developer-tools/
All the companies from Y Combinator’s W20 Demo Day, Part III: Hardware, Robots, AI and Developer Tools
Y Combinator’s Demo Day was a bit different this time around.
As concerns grew over the spread of COVID-19, Y Combinator shifted the event format away from the two-day gathering in San Francisco we’ve gotten used to, instead opting to have its entire class debut to invited investors and media via YC’s Demo Day website.
In a bit of a surprise twist, YC also moved Demo Day forward one week, citing accelerated pacing from investors. Alas, this meant switching up its plan for each company to have a recorded pitch on the Demo Day website; instead, each company pitched via slides, a few paragraphs outlining what they’re doing and the traction they’re seeing, and team bios. It’s unclear so far how this new format — in combination with the rapidly evolving investment climate — will impact this class.
As we do with each class, we’ve collected our notes on each company based on information gathered from their pitches, websites and, in some cases, our earlier coverage of them.
To make things a bit easier to read, we’ve split things up by category rather than have it be one huge wall of text. These are the companies that are working on hardware, robotics, AI, machine learning or tools for developers. You can find the other categories (such as biotech, consumer, and fintech) here.
AI and Machine Learning
Datasaur: A tool meant to help humans label machine data data sets more accurately and efficiently through things like auto-correct, auto-suggest and keyboard hotkeys. It’s free for individual labelers, $100 per month for teams of up to 20 labelers, with custom pricing for larger teams.
1build: Automatic, data-driven job cost estimates for construction companies. You upload your plans, and 1build says it can prepare accurate bids “in minutes.” The company projects a revenue run rate of over $600,000, and says it has completed estimates for mega companies like Amazon, Starbucks and 7-Eleven.
Handl: An API for turning paper documents — including handwritten ones — into structured data ready to be plunked into a database or CRM. While the company says that around 85% of its processing is handled by their AI, it’s backed by humans to validate data when the AI’s confidence is low. Nine months after launch, the company is seeing an ARR of $0.9 million.
Zumo Labs: Uses game engines to generate pre-labeled training data for computer vision systems. By synthesizing the data rather than collecting it from photos/videos of the real world, the company says it can create massive data sets faster, cheaper and without privacy issues.
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Teleo: Retrofits existing construction equipment to allow operators to control them remotely. The company says it has built a “fully functional teleoperated loader” since being founded three months ago, and plans to charge construction companies a flat monthly fee per vehicle. The company’s co-founders were previously head of Hardware Engineering and director of Product Manager at Lyft, with both having worked on Google’s Street View team.
Menten AI: Menten AI says it’s using “quantum computing and machine learning” combined with synthetic biology to design new protein-based drugs.
Turing Labs Inc.: Automated, simulated testing of different formulas for consumer goods like soaps and deodorant. Home products and cosmetics can be months of work for R&D labs. Turing has built an AI engine that helps with this process — much like the AI engines used in drug discovery — cutting down the time to days. It’s already working with some of the biggest CPG companies in the world. You can find our previous coverage on Turing here.
Segmed: Segmed is building data sets for AI-driven medical research. Rather than requiring each and every researcher to individually partner with hospitals and imaging facilities, Segmed partners with these organizations (currently over 50) and standardizes, labels and anonymizes the data.
Ardis AI: Ardis AI wants to build the foundation of artificial general intelligence — technology that read and comprehend text like a human. By combining neural networks, symbolic reasoning and new natural language processing techniques, Ardis AI can serve companies that don’t want to hire teams to do data extraction and labeling.
Agnoris: Agnoris analyzes a restaurant’s point-of-sale data to recommend changes to pricing, delivery menus and staffing. For $3,600 per year per restaurant location, Agnoris claims to be able to raise profits by 20%. The company started after the founder opened a restaurant that was packed yet losing money, so it built machine learning tools to improve margins and now it’s selling that software to all eateries.
Froglabs: Froglabs provides weather forecasting AI to businesses for predicting solar and wind energy production, delivery delays, staffing shortages, sales demand and food availability. By ingesting petabytes of weather data, it can save companies money by ensuring their logistics aren’t disrupted. Founded by a long-time Googler who started its Project Loon internet-beaming weather balloons, it’s now signing up e-commerce, retail, rideshare, restaurant and event businesses.
PillarPlus: PillarPlus is a platform that automates the blueprint-designing phase of a building project. It takes a design from an architect or contractor and maps out mechanical, fire, electrical and plumbing details, and estimates the bill of materials and project cost, steps that otherwise take months of work.
Glisten: Glisten uses computer vision and machine learning technologies to develop better, more consistent data sets for e-commerce companies. Its first product is an AI-based tool to populate and enrich sparse product data. Find our previous coverage of Glisten here.
nextmv: Nextmv gives its customers the ability to create their own logistics algorithms automatically — allowing businesses to optimize fleets and manage routes internally.
Visual One: Movement-detecting security cameras can bring up a lot of false positives: there’s motion, yes, but not necessarily anything harmful. Visual One has built an AI platform that integrates with home security cameras to “read” the specific movements that they detect. Owners can create customised alerts so they get notifications only for what they care about. The company’s software can check for furniture-destroying pets, package-lifting thieves, the death-defying antics of toddlers and more. Find our previous coverage of Visual One here.
PostEra: “Medicinal chemistry-as-a-service” is the idea here: PostEra’s platform can design and synthesize molecules faster and at a lower cost than the typical R&D lab, speeding up the research time it takes to test new combinations in the drug discovery process.
Hardware and Robotics
Cyberdontics: Robotics have already revolutionized surgery, courtesy of companies like da Vinci-maker, Intuitive. Cyberdontics is aimed at doing the same for oral surgery, beginning with crowns — one of the more expensive and time-intensive procedures. The company says its robot is capable of performing the generally two-hour procedure in 15 minutes, charging a mere $140 for the job.
Avion: Focused on inhabitants of difficult to reach areas in Africa, Avion is building a drone-based delivery system. The plans consist of medium and long-range medical drones tied to a centralized hub. The drones are hybrid and autonomous with vertical take-off capabilities, able to take 5-kg payloads as far as 150 kms.
SOMATIC: Industrial bathroom cleaning is a prime “dull”/“dirty” candidate to be replaced by automation. Somatic builds large robots that are trained to clean restrooms via VR. The system sprays and wipes down surfaces and is capable of opening doors and riding up and down in the elevator. Find our previous coverage of SOMATIC here.
RoboTire: Anyone who’s ever sat in a service shop waiting room knows how time-intensive the process can be. RoboTire promises to cut the wait time from 60 minutes down to 10 for a set of four tires. The company has begun piloting the technology in locations around the U.S. Find our previous coverage of RoboTire here.
Morphle: Designed to replace outdated analog microscopes, Morphle’s system uses robotic automation to improve imaging. The startup processes higher-resolution images than far pricier systems and with a much smaller failure rate. Morphle has begun selling its system to labs in India.
Daedalus: Founded by an early engineer at OpenAI, Daedalus is building autonomous software to allow industrial robots to operate without human programming, beginning with CNC machines. The company projects that it can improve productivity in the metal machining market by 5x.
Exosonic, Inc.: Exosonic makes supersonic commercial aircraft that don’t have to produce a loud sonic boom, so they can be flown over land. Its goal is a plane that can fly from SF to NYC in three hours. The CEO worked on NASA’s low-boom X-59 aircraft while at Lockheed Martin. Exosonic now has letters of intent from a major airline and two Department of Defense groups, plus a $300,000 U.S. Air Force contract.
Nimbus: Founded by a serial entrepreneur and based in Ann Arbor, Mich., Nimbus is developing the next-generation vehicle platform for urban transportation. Founder Lihang Nong previously launched the fuel-injection systems developer PicoSpray and is now looking to answer the question, “Can a vehicle be several times more space and energy efficient than today’s cars while actually being more comfortable to ride in?”
UrbanKisaan: UrbanKisaan is a vertical farming operation based in India that delivers fresh produce subscriptions to households. Its farms of stacked-up hydroponic tables can be located near cities with just 1% of the land usage of traditional agriculture, and there are no pesticides necessary. In a market with a growing middle class seeking healthy foods, delivering from farm-to-door could let UrbanKisaan control quality and its margins.
Talyn Air: Two former SpaceX engineers have developed a long-range electric vertical take-off and landing (eVTOL) aircraft for passengers and cargo. The startup has created an electric fixed-wing aircraft that is caught mid-air with a custom winged drone during take offs and landings, an approach that its founders say give this aircraft three times the range of its competitors, at 350 miles.
Developer Tools
BuildBuddy: Two ex-Googlers want to provide a “Google-style development environment” to all by building an open-source UI/feature set on top of Google’s Bazel software. The company says that their solution speeds up build times by up to 10x. It’s free for independent developers, with the price scaling from $4 per user to $49 per user depending on the size of the team and the features required.
Dataline: Meant to let websites gather analytics data from users who are using ad-blocking tools. Claiming that most ad-blocker users care mostly about display ads or cross-site tracking, the company says that first-party analytics gets hit as “collateral damage.” By acting as a “smart proxy” that runs on a sub-domain, Dataline avoids most ad-blocking systems (for now, presumably.)
Cortex: Many modern online software applications are powered by countless independent, purpose-focused tools — or “microservices.” Cortex monitors your app’s microservices to automatically flag the right person (hooking into Datadog/Slack/PagerDuty/etc.) when one breaks.
apitracker: Even if your website seems to be loading fine, the APIs you use to make it work might be having trouble, breaking things in not so obvious ways. Apitracker… tracks your APIs. It monitors the APIs you use, alerting you when one of them starts to fail and providing insights into their overall performance.
Freshpaint: Freshpaint’s “autotrack” system collects all pageviews/clicks/etc. across your site, allowing you to push it into tools like Google Analytics/Facebook Pixel etc. retroactively without requiring your dev team to make manual trackers for each event. The base plan is free for sites with fewer than 3,000 users and $300 for sites with up to 50,000 monthly users, after which point the pricing shifts to custom packaging.
Datree: Datree allows companies to set up rules and security policies for their codebase, and ensures those rules are followed before any code is merged. Charging $28 per developer (noting that it’s free for independent/open source projects), they’ve pulled in ~$230K in revenue to date. Find our previous coverage of Datree here.
fly.io: Deploys your app on servers that are physically closer to your users, decreasing latency and improving the user experience. If your app grows more popular in a certain city, Fly detects that and scales resources accordingly.
Sweeps: Sweeps claims that they can make your website 40% faster with one line of code, by more intelligently loading all of the third-party tools that a website is using. The team says that their tech not only improves speed but does so while improving SEO.
Orbiter: Orbiter is an automatic real-time monitoring and alert system integrated with Slack to ensure better customer service and revenue management.
Release: Product releases can be tricky. Release provides a staging management toolkit — it builds a staging environment each time there’s a pull request, allowing for faster/more collaborative development cycles.
Signadot: Signadot is monitoring and management software for the microservices that modern startups rely on to power their own applications and services, hopefully flagging issues before they become apparent to the end user.
Raycast: Raycast is a universal command bar for developers and many of the tools they use. Users can integrate apps including Jira, GitHub or Slack and take a Superhuman-like approach to completing forms and tasks. The team is pitching the tool as a way to help engineers get their non-engineering work done quickly.
Cotter: Cotter is building a phone number-based login platform that authenticates a user’s device in a workflow that the company’s founders say has the convenience of SMS-based OTP without the security issues. The startup is aiming to target customers in developing countries where email is less utilized and less convenient as a login.
ditto: Ditto’s founders are hoping to create the Figma for words, helping teams plan out more thoughtfully the copy they use to describe their products and workflows. The collaboration tool created by Stanford roommates Jolena Ma and Jessica Ouyang currently has 80+ different companies represented among their users.
Scout: A continuous integration and deployment toolkit for machine learning experiments inside a GitHub workflow.
ToDesktop: ToDesktop has designed a service to automate all of your desktop application publishing needs. It works with Windows, Mac and Linux and provides native installers, auto-updates, code signing and crash reports without the need for any infrastructure or configurations for developers.
DeepSource: DeepSource is a code review tool that allows developers to check for bug risks, anti-patterns, performance issues and security flaws in Python and Go.
Flowbot: Flowbot is a natural language, autocomplete search tool for coding in Python. It lets Python developers type in plain English when they can’t remember the exact function they’re thinking of, with Flowbot digging through documentation and considering the context to find the code it thinks you’re looking for.
PostHog: PostHog is a software service that lets developers understand how their users are actually working with their products. It’s a product analytics toolkit for open-source programmers.
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Great Career Opportunities
Wingate Dunross, Inc. is the leading California boutique Retained Search Firm for 36 years, setting multiple World-Records in the field.
__________________________________________________________________________________________________________________
ATTENTION: Scientists and Engineers
My Client is America's leading manufacturer of lab-grown diamonds. They have multiple outstanding openings at this time for which I am intently focused upon finding world-class candidates.
(1) Electrical Equipment Engineer (Wenatchee, Washington)
We are looking for an industrial equipment focused electrical engineer to install, maintain and troubleshoot plasma reactors. You'll be working with an experienced team of process engineers, maintenance technicians locally and collaborating with mechanical, electrical, and software engineers in San Francisco. Your goal will be to install new production tools, achieve maximum productivity for our production line through improving equipment capabilities and troubleshooting problems on the line.
The job will be hands-on, installing and maintaining tools in a manufacturing environment. You’ll be:
Installing, upgrading and maintaining plasma reactors (CVD tool)
Troubleshooting for industrial control/electrical systems including high voltage power supplies, controllers, sensors, pumps, PLC’s, valves, and other devices
Tracking and reporting on equipment uptime/downtime, root cause analysis, OEE, MTBF and the like
Working with manufacturing technicians, plan and execute upgrades and retrofits to improve tool reliability and process capabilities
Writing procedures and checklists, assisting and training maintenance
Working on multidisciplinary teams to solve complicated problems
Requirements:
Bachelor's degree in EE, or similar engineering discipline
3+ years of hands on engineering experience
Experience with industrial electronics and/or equipment control systems
A qualified candidate will have a subset of these skills:
Software: PLM system, 2D CAD (Autocad or Draftsight), PLC ladder logic, 3D CAD is a bonus
Ability to read and edit control schematics and P&ID drawings
Experience troubleshooting a variety of electrical systems from three phase AC power to low voltage DC board level signals. High voltage power supplies and microwave related experience is a bonus.
Operational knowledge of programmable power supply, oscilloscope, spectrum analyzer, and other common bench-top testing tools.
Hands on fabrication: soldering, electrical assembly, mechanical assembly, basic metalwork (drill, saw)
(2) Mechanical Equipment Engineer (South San Francisco, CA)
We are looking for a hands-on engineer to join our team to support improvement and operation of PECVD vacuum equipment. You'll be working with an experienced team of mechanical, electrical, and materials engineers and scientists to design new parts, document and communicate changes, and troubleshoot problems on manufacturing systems. The job will be hands-on, developing hardware devices in a manufacturing environment. You’ll be:
● Designing, engineering, building, testing, and optimizing parts for vacuum manufacturing systems
● Creating high quality engineering documents, including manufacturing and inspection drawings, and assembly documentation and procedures, using In-depth understanding of GD&T.
● Overseeing equipment projects on the manufacturing floor, such as upgrades, installation of new equipment, and test and qualification procedures
● Managing suppliers to construct parts and assemblies on time and within budget
● Selecting and integrating off the shelf hardware for process control, product quality measurement, and automated manufacturing tasks
● Working with a multidisciplinary team and learning new skills where necessary
● Analyzing performance of existing equipment and implementing your own solutions and improvements Your Qualifications:
● Bachelor’s degree in ME or similar from top tier school
● Strong mechanical engineering background with at least 1 - 5 years of professional experience with designing, building, testing and optimizing parts for vacuum manufacturing systems.
● Experience with project management and supplier/subcontractor management
● Minimum 3 years of SolidWorks experience
● Experience with PLM system, Engineering Release, Engineering Change Order
● Knowledge of ultra high vacuum tool and associated components such as pumps, gauges, sensors, MFC’s, pyrometers.
● Experience working in a manufacturing environment
● Experience with ultra high vacuum system, plasma reactor, CVD is a plus.
● Experience working with electro-mechanical control systems is a plus.
● Hands on fabrication: Machining (mill/lathe), soldering, and electrical assembly is a plus
(3) Modelling and Simulations Engineer (South San Francisco, CA) We are looking for a multiphysics modelling and simulation expert to help us make our world leading diamond production technology even better. You will apply your knowledge of physics, engineering, and simulation technology to create models that accurately describe conditions within complicated high-tech manufacturing systems, and use these models to assist process and equipment engineers in designing solutions. A desire to tackle difficult problems and work with a team to create innovative solutions is a must.
Responsibilities:
Creating models and simulations to describe and illuminate root causes of problems on our line
Developing new types of simulations to improve in-house analysis ability
Communicating and working with engineers to solve problems based on the results you find
Implementing and performing tests on actual hardware to validate your models
Designing parts and processes to take advantage of improvement opportunities you find
Working with a multidisciplinary team and learning new skills where necessary
Studying existing equipment and implementing your own solutions to the problems you find Requirements:
Advanced degree in in engineering or science from top tier school
3-10+ years of career & academic multiphysics simulation experience
Simulation software (ansys, comsol, star-ccm+, cst, etc.): 3 years minimum of full-time use
Independent, goal oriented problem solver
Knowledge of vacuum/plasma based manufacturing or scientific equipment and associated sensors and components (Pumps, valves, pressure sensors, spectrometers, MFC's, pressure controllers, pyrometers, etc.)
Experience designing and manufacturing parts, especially for vacuum environments
Experience working in a manufacturing environment
#4) R&D Engineer (South San Francisco, CA)
We are looking for an ambitious and hands-on engineer to take responsibility for investigating unique manufacturing processes and technologies, and developing in house hardware solutions to pass to production. You'll be working with an experienced team of mechanical, electrical, and materials engineers, and will be encouraged to gain experience in different areas. The position will involve hands-on work with complex semiconductor style plasma CVD manufacturing equipment, requiring knowledge of physics, chemistry, and mechanical and electrical engineering.
Responsibilities:
Developing ideas and requirements from scientific papers on new types of processes and hardware to try in our factory
Developing hardware and executing experiments with the goal of improving our manufacturing process
Working with a multidisciplinary team and learning new skills where necessaryPersonally operating and collecting data from manufacturing equipment for R&D purposes
Evaluating effectiveness of various manufacturing processes by comparing production rates and cost of operation
Requirements
Bachelor's degree in Physics, Mechanical/Electrical/Chemical Engineering, or similar field3+ years of hands on experience in an R&D environment
Ability to confidently operate complicated prototype equipmentSelf starter, capable of identifying needs and implementing solutions without help
A desire to learn new skillsEffective communication, must be comfortable working closely with team members
Flexible, and adept at working in a fast paced environment
Software: JMP or other statistical analysis package, CAD (solidworks), FEA or other simulationKnowledge of UHV vacuum manufacturing, including equipment and practices
Experience with Labview
Proficient writing queries in SQL, and/or NoSQL
Experience working hands-on with semiconductor style manufacturing equipment
Experience with design of experiments
(5) Director, Process Engineering (South San Francisco, CA)
We are looking for an ambitious and hands-on manufacturing expert to manage process engineering in our factory. You will manage a small team of skilled engineers to solve day-to-day manufacturing problems, track and improve key production and quality metrics, run experiments to test new ideas, and design and implement improvements. The job will require some knowledge of vacuum deposition equipment, manufacturing technology, chemistry, physics, and material science. A desire to lead a small nimble team is a must.
Responsibilities:
Ownership of manufacturing hardware technology development projects
Support for introduction of new technology to the manufacturing line
Troubleshooting for difficult problems brought by other departments
Project management from concept development, prototyping, testing, and deployment
Identifying new engineering or technical needs, recruiting talent where needed
Consult for the production team on best methods for use of equipment to improve production metrics
Effective management of engineering time and funding
Requirements:
Bachelor’s degree in Engineering or Science
Experience managing an engineering team
10+ years of hands on experience in high tech manufacturing
Self starter, capable of identifying needs and implementing solutions without help
Effective communicator: must provide information to a variety of parties, from guidance and documentation for manufacturing technicians, to high level reports for the executive leadership team
Team Player who will work with equipment and manufacturing leads to jointly operate an effective factory
Knowledge of UHV manufacturing, especially PECVD
Software: JMP, Tableau, or other statistical analysis package
Experience working hands-on with semiconductor style manufacturing equipment
Experience with crystal growth
Experience with design of experiments
(6) Director, Hardware R&D (South San Francisco)
We are looking for an experienced manufacturing technology expert to manage development of new technology for our factory. You will manage a small team of skilled engineers to develop new capabilities for the most advanced diamond manufacturing facility in the world. The job will require a diverse knowledge of including all disciplines involved in high tech manufacturing, such as chemistry, physics, control systems, mechanical and electrical engineering, and material science. A desire to lead a small nimble team is a must.
Responsibilities:
Ownership of manufacturing hardware technology development projects
Support for introduction of new technology to the manufacturing line
Troubleshooting for difficult problems brought by other departments
Project management from concept development, prototyping, testing, and deployment
Identifying new engineering or technical needs, recruiting talent where needed
Consult for the production team on best methods for use of equipment to improve production metrics
Effective management of engineering time and funding
Requirements:
Bachelor’s or higher degree in Engineering or science
Experience managing technology development teams
10+ years of hands on experience developing new technologies
Self starter, capable of identifying needs and implementing solutions without help
Effective communicator, must be comfortable transferring knowledge to other teams
Knowledge of UHV manufacturing, especially PECVD, thin film deposition techniques, or crystal growth
Software: 2D/3D CAD (Solidworks, Autocad, etc.), Statistical analysis software, business productivity suites
Experience working hands-on with semiconductor style manufacturing equipment
Experience with design of experiments
If you have an interest in pursuing one of these outstanding career opportunities, or simply have referrals or suggestions, please let me know. Unsolicited resume submissions are accepted, as well. Cover letters or explanatory notes are also welcomed.
Best Regards,
Nicholas Meyler
President
Wingate Dunross Executive Search
ph (818)597-3200 ext. 211
email: <[email protected]>
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IBM, Huawei, And Hikvision Are Battling To Sell Facial Recognition Technology In Dubai
BuzzFeed News; Getty Images
DUBAI, United Arab Emirates — As a backlash against facial recognition technology grows in the US, a host of Chinese and American firms are competing to supply Dubai’s police force with biometric surveillance and artificial intelligence products.
This month San Francisco banned police from using facial recognition altogether, and other bills in the US aim to do the same. Amazon faced pressure last week from activist shareholders over sales of its Rekognition system to US government authorities. And Rep. Alexandria Ocasio-Cortez expressed concern that face recognition could be used as a form of social control.
But even as the technology comes under more scrutiny in the United States, tech giants such as IBM, and China’s Hikvision and Huawei, are marketing biometric surveillance systems in the UAE, where citizens have fewer options to push back. The UAE has used cellphone hacking software to spy on hundreds of dissidents, journalists, and suspected criminals, and has invested heavily in surveillance technology, according to human rights groups and international media reports.
“It is absolutely terrifying,” said Sarah Aoun, a digital rights technologist who works with human rights activists, including in the Middle East, on privacy and security. “In a place like Dubai, where there is not much freedom of expression and people are being jailed for what they say, when you introduce artificial intelligence, it’s used by systems of power to reinforce their control over the population. They are weaponizing this technology.”
“They are weaponizing this technology.”
Police in Dubai have begun rolling out an ambitious program, dubbed Oyoon, the Arabic word for “eyes,” that will implement facial recognition and analysis driven by artificial intelligence across the city. Police say the program will reduce crime as well as traffic accidents. An analysis of hundreds of government procurement and regulatory documents make clear the scope of Dubai’s high-tech policing ambitions, showing the police have sought video analytics platforms meant to record and analyze people’s faces, voices, behavior, and cars in the time it takes to do a Google search. And a review of dozens of company marketing materials and interviews with officials show global tech giants are eager to provide the police with the technology they are seeking.
Facial recognition is being taken up by police departments and security forces all over the world, from China and Ecuador to the US and UK. Biometric surveillance systems have swept up the faces, voices, and personal traits of millions of people into government databases in countries across the world with little to no transparency or regulatory oversight.
It has sparked an outcry from civil rights advocates who say the technology’s unchecked use in public spaces presents a grave threat to individual privacy and could exacerbate the most abusive practices of police forces, from racial discrimination to arbitrary detention.
At a recent government-organized conference on artificial intelligence in Dubai, representatives from technology companies including Huawei, which the Trump administration recently put on a trade blacklist as a threat to national security, China’s Hikvision, and IBM said they saw the UAE and other countries in the Persian Gulf as an exciting market to sell their video analysis platforms, which they say can do everything from analyzing the behavior of groups to automatically blacklisting individuals based on their faces.
Other governments in the Persian Gulf, such as Bahrain and Saudi Arabia, are also using cellphone hacking and other high-tech surveillance measures to monitor and intimidate dissidents, including exiles. The UAE meanwhile has poured money into developing its surveillance capabilities.
“In looking at the way they’re using spyware, they are more aggressive about becoming a surveillance power,” said Bill Marczak, a postdoctoral researcher at the University of California, Berkeley, and a research fellow at Citizen Lab who is one of the foremost analysts of surveillance systems in the Persian Gulf. “They’re not only targeting people in the UAE but they’re also using spyware beyond their borders to conduct operations in other countries.”
Megha Rajagopalan / BuzzFeed News
A still from a demonstration video at the AI conference in Dubai.
The police have said little about the specific kinds of technologies that are being used in the Oyoon program. BuzzFeed News reviewed procurement records that show the police have sought face and voice recognition technology since as early as mid-2016, including products like the Vectra M3, a program marketed toward skincare professionals that aims to create a 3D model of a person’s face, and NeoFace Reveal, a software made by the Japanese company NEC that says it matches faces from photographs and crime scene videos to preexisting databases of images. The police also sought a voice recognition program called Batvox, described as a “new public security weapon” by its manufacturer, Massachusetts-based Nuance.
The Oyoon program, which was unveiled last January, aims to bring thousands of video feeds from cameras used by government authorities throughout Dubai into a central command center, according to local news reports and people familiar with the program. The command center uses artificial intelligence and face recognition to identify security threats. “[Oyoon] security system employs artificial intelligence to watch Dubai around the clock!” proclaims a graphic on a PowerPoint slide in a presentation on the UAE’s artificial intelligence strategy given by an adviser to the UAE government.
Police in Dubai have boasted the program has already led to the arrest of more than 300 people.
Studies have shown racial bias baked into leading facial recognition platforms, raising questions about misidentification of suspects. In the UAE and elsewhere, there have been no independent audits of these platforms for accuracy or freedom from bias.
“The application of artificial intelligence to CCTV systems opens a Pandora’s Box of uses and misuses,” said Sam Samuels, a former police officer and consultant on CCTV systems in Dubai. “At the end of the day it will be a human being who has to validate the information generated by the system.”
While facial recognition has proved divisive in the US, it is in China that its use has been particularly controversial. The Chinese government has come under fire internationally for large-scale surveillance of ethnic minorities. Hikvision, the world’s largest supplier of surveillance products, already supplies Dubai — as well as cities from London to Shanghai — with thousands of CCTV cameras. It has also outfitted mosques and internment camps with face recognition cameras in China’s far west — a region where Muslim minorities are under unprecedented surveillance and where upward of a million people have disappeared into the camps. But at the AI conference in Dubai, Robert Wang, an executive for Hikvision in the Middle East, did not mention the company’s work in Xinjiang. Instead, he set up China’s approach to surveillance and security as an example for the audience of UAE government officials and corporate executives.
“The challenge for us now is not that we no longer have enough video. The problem is that we have too many videos.”
China, he said, is one of the safest countries in the world, saying it needs relatively few police officers per capita.
He said the reason is the 250 million surveillance cameras the country’s domestic security authority has installed throughout the country.
“This kind of massive data provides for us all of the evidence, and all of the clues,” Wang said. “The challenge for us now is not that we no longer have enough video. The problem is that we have too many videos.”
BuzzFeed News spoke to several former detainees, prisoners, and human rights advocates who focus on the UAE. They said the widespread use of face recognition in Dubai is likely to lead to misuse and could do serious damage to privacy rights.
“This is good technology if it’s used in the right way,” said Khaled Ahmad, a computer engineer, prisoners’ rights campaigner, and former detainee in the UAE. “But with the UAE government, they arrest people just for tweeting, for publishing on Facebook, just for speaking about freedom and human rights. It’s good technology if it’s used against criminals, but not if you use it to cover people’s mouths.”
The Oyoon program is being rolled out in cooperation with several UAE government ministries, including the State Security Agency, according to the Dubai police. In a sign of how seriously Dubai’s leaders are taking the program, Dubai’s Crown Prince Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum visited a local police station in a district where facial recognition–equipped cameras were already thought to be in place last October.
The police also sought programs to help with video analytics, extracting deleted data from computers, recognizing license plates, and breaking into cellphones, procurement records showed.
But the true power of video analytics lies in not any one of these functions, but in the profiles it enables law enforcement to build of individuals when many sources of data are put together.
Dubai police did not reply to repeated requests for comment on the Oyoon program by the time of publication.
Hikvision and Huawei declined to comment on the statements in this article.
A spokesperson for IBM said the company has “robust processes in place to ensure potential client engagements are consistent with our values, as well as US and local laws.”
Megha Rajagopalan / BuzzFeed News
Facial recognition has been around for more than a decade. One of its earliest known uses for law enforcement was in Tampa, Florida, in 2001. The technology remains problematic and has faced questions about everything from its ability to distinguish between nonwhite faces to its overall accuracy, but it is now being widely used by law enforcement agencies to build profiles of individuals in new ways.
File storage costs have become significantly cheaper over the past few years, making it much easier for users to store video. And algorithms that adjust to compensate for real-world variations in people’s appearances, as well as new technology that makes it easy to slice videos frame by frame, have made facial recognition and other biometric surveillance programs cheaper and more effective, said Os Keyes, a PhD student at the University of Washington who is researching the history of facial recognition.
One thing that’s changed is the speed at which sophisticated computer programs quickly search and analyze thousands of hours of camera footage. A camera in a shopping mall, for instance, can capture many different angles of your face over time, enabling a computer to model the way your head looks from different angles and making it easier for police to spot you.
“What they’ve come up with is algorithms that, instead of comparing two photos of you, take a whole sequence of photos of you and use it to construct a 3D model of your head, which they can then rotate to the angle of a photo they already have,” Keyes said. “If you’re taking a video, you can just get 10 frames of a person and wait for one frame where they look up and don’t have a baseball cap in the way.”
And now video analytics programs can search footage for combinations of people’s traits. An official from BriefCam, an Israeli firm that is owned by Japan’s Canon and has a tech partnership with HP Enterprise, demonstrated this at the AI conference in Dubai, showing a screen with a search bar that pulled up dozens of women who had worn red dresses with midlength sleeves in a shopping mall.
“The main use case is security,” the BriefCam official said, adding that BriefCam would be happy for the opportunity to work with the UAE security apparatus.
Stephanie Weagle, chief marketing officer for BriefCam, said in a statement that biometric technology has “significant public safety benefits” including identifying suspects and finding missing children. “The expectation is that technology designed for public safety is used in accordance with applicable laws and to uphold civil rights,” she said.
China’s Huawei displayed a data analysis platform labeled FusionInsight that could quickly comb through thousands of hours of footage for faces and license plates. A company official said the platform had the ability to blacklist individuals. When asked about this, Huawei declined to comment.
Microsoft displayed a video analytics platform that claims to detect the face, age, and emotional state of people seen on camera, as well as the size of crowds, though company officials did not refer to applications in law enforcement. Asked whether the platform is being used in the UAE, a spokesperson for Microsoft pointed BuzzFeed News to a blog post by the company’s president calling for governments to regulate facial recognition technology.
To illustrate the prowess of Hikvision’s technology, Wang, the company executive, showed a six-minute film shot in the style of a primetime cop drama. In the film, a team of Chinese police officers, whose voices had been dubbed in American-accented English, use the company’s suite of products to track down a jewel thief wearing a black ski mask. The police eventually find the suspect using footage of a small black tattoo on his wrist, matching images of his license plate–less car, searching for people who frequently appeared near the jewelry shop in the weeks past, and directing cameras in public spaces to find him by using images of his face. The man later tries to hide from cameras by wearing a baseball cap, but it doesn’t work.
“Add him to the criminal database and track him down,” the lead police officer barks.
At the end of the film, Wang told the audience the surveillance technology, and the way it could work together, was all real — “not science fiction,” he said.
“This is not a system that one manufacturer can build alone,” he added. “I’m glad to be here today if users and partners are interested. We would like to be open and to cooperate.”
Chinese companies like Hikvision, which have benefited from Chinese government programs promoting the development of homegrown artificial intelligence technologies and from being able to test their tech on the Chinese public, have become leading players in facial recognition. Hong Kong–based SenseTime, the world’s most valuable AI startup, told BuzzFeed News it is setting up an office in Dubai — the company’s first outside Asia. Discussions between Smart Dubai, the city’s “smart city” authority, and SenseTime about implementation of its facial recognition products are progressing, according to people with knowledge of the matter. Smart Dubai said it met with SenseTime in Shanghai last year to identify possibilities for working together. Asked about the discussions, SenseTime said it could not disclose “commercially sensitive information.”
Hong Kong–based SenseTime, the world’s most valuable AI startup, told BuzzFeed News it is setting up an office in Dubai — the company’s first outside Asia.
George Huang, head of SenseTime’s international business group, said at the conference that mining data from social media could help provide information for public security purposes.
The data helps SenseTime and other AI companies around the world train algorithms to manage public safety, he said. Data like this, he added, is crucial for smart cities.
A spokesperson for SenseTime said the company is “committed to fair and responsible applications of AI technology. In addition to complying with local laws and regulations in the markets we operate in, we also have internal processes to safeguard our technology to ensure it is being used in a fair and responsible manner.”
Beyond recognizing individuals, video analytics platforms have the ability to alert law enforcement authorities to gatherings of people in real time. IBM, Huawei, and other companies displayed platforms that could automatically measure both crowd sizes and characteristics — for example, flagging a certain article of clothing, whether someone was walking in a certain direction, or whether someone was lingering for too long. It’s easy to imagine uses for this kind of technology outside policing — determining whether everyone on a dangerous construction site is wearing a hard hat, for instance, or automatically flagging an injured person who has keeled over. But video analytics platforms like these can also easily be used by security services to quickly crush protests and other peaceful gatherings. A representative for IBM at the conference was quick to tout the company’s PowerAI Vision platform’s utility for law enforcement, saying the company would like to sell it to police and security services in the UAE. A spokesperson for IBM noted the platform could not recognize individual faces, but only label “objects” in a video. Demonstrations of the product show labels on both objects and human beings.
“Watching the traffic of people, we can prevent crimes and terrorism.”
Huang promoted SenseTime’s crowd analysis software as key to managing the density of crowds. It can automatically count the number of people present and analyze the level of safety, he said, flagging “abnormal behavior,” including too many people gathered at once. “Watching the traffic of people, we can prevent crimes and terrorism,” he said.
“We can understand the time, the location, the method of the crime, the moving habits and area of activity of the suspect,” he added. “That allows the city to invest more efficiently in fighting criminals.”
A demo of SenseTime’s product showed a crowd with color-coded circles that appeared around people’s bodies, when they loitered too long, for instance, or when “chaos” happened, referring to disorder.
The extent to which Dubai’s security services and law enforcement already use facial recognition cameras — as well as complementary tech like gait recognition, car recognition, and data analysis — is not known, though analysts said it is likely widely in use. Requirements published by Dubai’s regulator for the security industry specify that private video surveillance systems must be connected to a centralized system called VideoGuard, which allows Dubai police system access.
“Every single conference center, every single hotel, every single road today has a camera. That is true of the UAE, it’s true in the US, it’s true in China and everywhere,” Omar Al Olama, UAE minister of state for artificial intelligence, told a Gulf News reporter in May. “We have no ambition to do this for the sake of surveillance. We’re going to do it if there is a way for us to become the safest city on earth.”
Dubai police have purchased technology for license plate detection, which developed much earlier than facial recognition, for several years, according to procurement records. And as part of the Oyoon program, Dubai has placed facial recognition cameras in at least one city neighborhood called Al Muraqqabat. Located in eastern Dubai, it’s a relatively dense residential area that’s also home to shopping malls and cinemas. Industry analysts said it is likely that face recognition cameras and other biometric surveillance systems are already in wider use in the UAE, including in Dubai and Abu Dhabi, but that authorities have not yet made it public.
AFP Contributor / AFP / Getty Images
A police officer walks through a security tunnel at a technology exhibition at the Dubai World Trade Centre, October 2017.
The UAE, with a population of about 9.5 million people, has among the highest rates of political prisoners per capita in the world, according to scholar Kristian Coates Ulrichsen. In the years since the Arab Spring uprisings swept across the Middle East, the UAE has invested in surveillance technology, which it has used to spy on both activists and dissenters within its own borders, as well as conduct espionage operations abroad. Reuters reported in January that the UAE retained US operatives to hack into the iPhones of hundreds of activists, political leaders, and suspected terrorists.
“They focus on preventative surveillance,” said Joe Odell, a campaigner at the International Campaign for Freedom in the UAE. “It’s about control to prevent street mobilizations through establishing a wide-reaching surveillance state, where they can nip anything in the bud before it even happens. They’ve spent millions of pounds on that.”
Human rights activists say torture is common in the prison system. Several former UAE prisoners interviewed by BuzzFeed News, who had been jailed or detained over allegations ranging from leaking information to defaming the country, said they had faced abuses and torture in prison, including beatings, electric shocks, and sleep deprivation. They also said they had their eyes scanned, their fingerprints taken, and their devices confiscated — treatment that prisoners in countries including the US also face. Asked about these allegations, Dubai police said the issue was not within their jurisdiction.
Ahmad, the Palestinian computer engineer, did technical support for a firm controlled by a senior Emirati government official before being detained without explanation in Abu Dhabi for months. He said he was blindfolded and taken to a secret prison whose location he still does not know. During interrogations about his work — police seemed to believe he had access to sensitive information — security agents put him in an electric chair, turned it on for 20 seconds at a time, and threw cold water on his face to revive him when he passed out from the pain.
Ahmad said one of the first things the police did was confiscate his cellphone and computer. They demanded the passwords, and he gave them incorrect ones, hoping to stall for time. His interrogators later told him they had broken into the devices anyway. He believed them, he said — one day an officer began joking with him about a woman friend whose pictures were on his phone. She was sexy, the officer said.
Five months after he was first detained, Ahmad was blindfolded and taken by car back to the airport in Abu Dhabi. He was deported to Lebanon without any explanation as to why he was detained in the first place. The police even apologized and told him he was innocent, Ahmad said.
“They’ve imprisoned all those people or intimidated and harassed them into keeping quiet.”
Ahmad eventually moved to Sweden, where he now lives; after he became a Swedish citizen, he began writing about his ordeal in prison. His former employer sent him a letter, which he shared with BuzzFeed News, stating that he could be prosecuted under the UAE’s cybercrime law for allegedly stealing confidential information from the company. Though he now lives abroad and says he has nothing to hide, the idea that he’s being surveilled through his devices is something he thinks about all the time.
Last year, Ahmed Mansoor, who is perhaps the country’s best known human rights activist, was sentenced to 10 years in prison and fined about $270,000 over posts he made on Facebook and Twitter that a court found had damaged the UAE’s reputation abroad as well as its “social harmony and unity.” People in the UAE can be arrested under the country’s cybercrime law, which bans defamatory statements on social media.
Mansoor, who had called attention to human rights abuses throughout the Middle East on his Twitter account, had been under heavy surveillance by his government and had been targeted with spyware on his devices.
“Ahmed was very open about what he did and why he did it, but he was very conscious of being under surveillance. He would meet people in hotel lobbies, and he’d leave his phone at home,” said Nicholas McGeehan, a researcher who formerly worked for Human Rights Watch in the region. “He assumed he’d be under surveillance anyway. You couldn’t make a phone call, couldn’t send an email — everything was funneled through one or two interlocutors who were willing to take a chance.”
“They’ve imprisoned all those people or intimidated and harassed them into keeping quiet,” he added.
Controls on social media and the perception that authorities may be spying on cellphones has already chilled discourse, say free speech advocates and former UAE prisoners. Rights groups said they worried the growing presence of surveillance technology in physical spaces could make things even harder.
“The government has shown a willingness and a desire to go after peaceful opposition,” said Citizen Lab’s Marczak, who has worked with Mansoor. “If they have powerful tools to track your movements outside your house, and then they have spyware to hack the devices inside your house, then there’s pretty much nowhere that you’re not being watched.” ●
CORRECTION
May. 29, 2019, at 14:37 PM
Alexandria Ocasio-Cortez’s name was misspelled in an earlier version of this post.
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Suggestion On Things To Note When Picking Dietitian San Francisco
By Kenneth Patterson
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Suggestion On Things To Note When Picking Dietitian San Francisco
By Kenneth Patterson
Hospitals and the general public require the services of these dietitians. The professionals enable the society to maintain the healthy living condition which can make their health remain stable. Provision of the right menu to use for different families can be an added advantage to those who are relying on them. Below are vital points to check when selecting Dietitian San Francisco. The medical practitioners must have a valid license from the board of nutritionist. The board usually asses the qualities of these professionals both physically, mentally and psychologically. The assessment is done to ensure that they present the best individuals who can handle the cases of malnutrition patients without any problem. The board does give examinations to look on specific aspects that can lead to the competent nutritional officer. Check on the academic qualifications of the nutritionist that you want to work with. The minimum time that these specialists are required to take in their studies is four years. The four-year course should equip them with relevant skills that can help them transform the lives of those suffering from the diseases. They are required to have a diploma, degree or masters in the field of food nutrition and dietetics. Check on the technical skills available for the nutrition expert. Technical skills that these professionals should have to include the ability to perform diagnosis within the lab for the debris removed from the patient. The individual should know various methods to perform microscopy on samples obtained from the patient. The common methods used provide a good procedure for determining the nutrition problem. Consider the ability of these malnutrition specialists to remain flexible. The individual should be able to work within any environment despite the conditions. Most of the non-governmental organizations hire these professionals to go and help them provide better health care for the public in different places. The professionals can still work with hospitals where they are stationed at the nutrition department for pediatrics. Ensure that this nutrition specialist can perform follow up on patients. Patients suffering from cases such as goiter need follow up after the treatment which involves chemotherapy. The chemotherapy can cause a lot of damage to tissues, and this will require one to make the follow-up. Follow up is mainly to check for the progress of these sick people who were under medications. The expert dealing with nutrition conditions must know how to classify different foods. There are several types of foods present in the universe. All of them can be classified as either carbohydrates, proteins, vitamins, and minerals. The ability to classify the food into various categories will depend on how the lab analysis will be done. The lab specialist should provide the relevant nutrients present in the food to help nutritionist give the right direction on classes. The medical expert should have the ability to solve the problem concerning nutrition defects. Diseases can cause fatal effects such as blindness. When one is suffering from such diseases, they are supposed to consult the nutritionist who can provide a better solution for the patient. The solution should help the patient recover their normal state.
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