#Jingwei wan

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is it canon in wan jingwei's lore that she cucked the emperor several times? umm

[winttube]

Jingwei wan

Institute of Biomedical and Clinical Science.Web of Science ResearcherID: Q-7959-2019.This current discovery could address the urgent need for treatment that could provide an effective alternative to invasive surgery. Brain swelling after a stroke or epilepsy is a common and devastating problem for individuals and their families. NCC, NKCC2, NKCC1, KCC2 and KCC3, and their upstream regulatory mechanism by the WNK-SPAK/OSR1 signalling pathway in mammalian cells and tissues under physiological and pathological conditions (Cell Metabolism 2017 Nature Medicine 2017 Nature Communications 2017  eLife 2018 Neuron 2019 Science Signalling 2019a, 2019b Molecular Psychiatry 2021 and Genetics in Medicine 2022), and subsequently led to the development of a drug-like molecular ZT-1a (Nature Communications 2020 Stroke 2022 US Patent WO2020072386, European Patent EP3873439 (A1), Canadian Patent CA3115075 (A1), China Patent CN113365614 (A)), as a neuroprotective agent. Recent research in Zhang Laboratory has greatly improved our understanding of the function of Chloride ion transporters, e.g. In 2017, Jinwei joined the Faculty of the University of Exeter Medical School, where his KCC2/ NKCC1 investigations can gain greater impact by integration with the clinical resources and basic science research at The Institute of Biomedical and Clinical Sciences. Since 2014, Jinwei's research focused on CU元/KLH元-WNKs-SPAK/OSR1-cation chloride cotransporters (CCCs) signalling in cellular chloride homeostasis and cell volume regulation in collaboration with Professor Kristopher Kahle at Yale University School of Medicine. While there, he studied LRRK2 associated Parkinson's disease, and contributed to the discovery of the most potent LRRK2 kinase inhibitors TAE684 and TTT3002, most selective LRRK2 inhibitor GSK2578215A, and the first brain penetrable LRRK2 inhibitors HG-10-102-01 and JH-II-127. Since 2011, Jinwei pursued his interest in cellular signalling with a post-doctoral fellowship at the Medical Research Council (MRC)- Protein Phosphorylation and Ubiquitination Unit (PPU) in Dundee with Professor Dario Alessi (FRS), and with Professor Nathanael Gray at Harvard Medical School. While there, he studied natural bioactive compounds and their applications in human health. He then obtained a PhD degree in Biotechnology from Newcastle University UK in 2011. While there, he studied marine ecology and cold-adapted enzymes from deep-sea bacteria. He then obtained a MSc degree in Marine Microbial Biochemistry and Molecular Biology at The Third Institute of Oceanography (Xiamen), State Oceanic Administration China in 2007. While there, he studied mutagenesis of Aspergillus niger for higher yield of multicomponent enzymes. Fellow of the Higher Education Academy, 2019ĭr Jinwei Zhang obtained a BSc degree in Bioengineering from Fujian Normal University China in 2003.PhD, 2011, Newcastle University, Newcastle upon Tyne, UK.MSc, 2007, Xiamen University (Xiamen City), and the Third Institute of Oceanography (Xiamen City), State Oceanic Administration, China.BSc, 2003, Fujian Normal University (Fuzhou City), China.All these studies concern with elucidating and targeting ion transporters, kinases, protein-protein interactions using genetic mouse models, mass spectrometry, small molecules, electrophysiology, and CRISPR/Cas9 gene editing technologies to aid discovery and validation of new potential drug targets. He studies signalling pathways that associated with human diseases, for examples, the neurodegenerative diseases including the LRRK2 associated Parkinson's disease (PD), the amyloid precursor protein (APP) and Tau associated Alzheimer's disease (AD), neuropsychiatric disorders including epilepsy (WNK-SPAK-KCC2), High Blood Pressure & Kidney Disease (CU元/KLH元-WNK-SPAK-NCC) etc. He gained a solid theory and practice of training in the field of natural bioactive compounds, biochemistry and molecular biology, enzymology, pharmacology, drug discovery, signaling transduction and electrophysiology during his academic degrees and postdoc trainings. Dr Jinwei Zhang has a very wide-ranging expertise, which makes him uniquely positioned to develop research at the interface between fields.

[chinesetong-china]

Learn Chinese and Chinese Culture in stories｜Chinese legends｜The bird Ji...

Learn Chinese and Chinese Culture in stories｜Chinese legends｜The bird Jingwei fill up the sea with pebbles‘jing wei tian hai’

 In the East China Sea, A bird named Jingwei brought pebbles into the sea day after day, and tried to fill the sea. The sea laughed:" Little bird, you can not fill me up even you do this for a thousand years ." The bird replied ," Even for a million years, I will fill you up ." This is the well-known story of ‘Jingwei tian hai’ in China.

 The idiom "Jingwei Tian Hai" represents the struggle of human beings against the fate and nature, which symbolizes the spirit of never giving in to suffering.

 在东海上，有只名叫精卫的小鸟日复一日地衔来树枝石头填入海中，它要把大海填平。大海嘲笑道：‘小鸟儿，你这样就算干上一千年，也休想把我填平’。小鸟回答道‘就算是一百万年，我也要把你填平’。这就是中国家喻户晓的‘精卫填海’的故事。

 ‘精卫填海’这个成语表达了人类对自然命运的抗争,象征着面对磨难，永不屈服的精神.

   CONTENT

Jīng Wèi tián hǎi

精卫填海

The bird Jingwei fill up the sea with pebbles

 Yuan gu shi qi ,ren lei sheng cun jian nan

远古时期，人类生存艰难

In ancient times ,human survival was difficult

 Yan di zui xiao de nv er ming jiao Nv Wa

炎帝最小的女儿名叫女娃

Yan Emperor's youngest daughter named Nuwa

 Ta tian zhen huo po ,dui shi jie chong man hao qi

她天真活泼，对世界充满好奇

She was innocent and lively, curious about the world

 Fu wang ,tai yang shi cong shen me di fang sheng qi de

父王，太阳是从什么地方升起的

Dad, where doese the Sun rise from

 Zai dong hai ji wan li wai de gui xu

在东海几万里外的归墟

From Gui xu, which is tens of thousands miles from the East China Sea

 Shi tai yang sheng qi de di fang

是太阳升起的地方

It is where the Sun rise from

 Na li you jin yu xiu jian de gong dian

那里有金玉修建的宫殿

There are palaces built with gold and jade

 Tong ti xue bai de niao shou

通体雪白的鸟兽

All white birds and beasts

 Jie man zhen zhu de yu shu

结满珍珠的玉树

Jade trees with pearls

 Zhe me mei de di fang

这么美的地方

Such beautiful place

 Wo yi ding yao qu kan kan

我一定要去看看

I must go there and have a look

 Yi tian Nv Wa du zi hua zhe xiao chuan

一天女娃独自划着小船

One day Nv Wa rowed her boat alone

 Chao dong hai tai yang sheng qi de di fang chu fa le

朝东海太阳升起的地方出发了

to the East China Sea where the Sun rise

 Tu ran ,hai shang qi le feng bao

突然，海上起了风暴

Suddenly, there was a storm at the sea

 Yi ge ju lang ba Nv Wa de xiao chuan xian fan le

一个巨浪把女娃小船掀翻了

A huge wave overturned Nvwa's boat

 Nv Wa, ni kuai hui lai

女娃，你快回来

Nvwa, come back

 Yan di zai ku han ta de nv er

炎帝在哭喊他的女儿

Emperor Yan was crying out for his daughter

 Nv wa zai ye hui bu qu le

女娃再也回不去了

Nvwa can’t come back for ever

 Fu wang ,fu wang ,dui bu qi ,wo yao zou le

父王，父王，对不起，我要走了

Dad, Dad ,sorry , I must go

 Ni qu na er ya ,Nv Wa

你去哪儿呀，女娃

Where are you going , Nvwa

 Wu qing de da hai duo qu le wo de sheng ming

无情的大海夺取了我的生命

The merciless sea took my life

 Wo yao qu tian ping ta

我要去填平它

I am going to fill it out

 Rang da hai zai ye bu neng shang hai wo men

让大海再也不能伤害我们

Let the sea never hurt us again

 Nv Wa hua shen yi zhong shen niao

女娃化身为一种神鸟

Nuwa incarnated as a divine bird

 Ta mei tian cong xi shan xian lai shi tou he cao mu tou ru dong hai

它每天从西山衔来石头和草木投入东海

It brought stones and vegetation from the West Mountain to the East China Sea every day

 Fa chu ‘ jing wei ,jing wei ‘ de bei ming

发出‘精卫，精卫’的悲鸣

Crying ' Jingwei, Jingwei'

 Hao xiang zai hu huan ta zi ji

好像在呼唤它自己

As if calling itself

 Ri fu yi ri ,nian fu yi nian ,zhi dao jin tian

日复一日，年复一年，直到今天

Day after day, year after year, until now

  KEYPOINTS

Hǎi

海 sea; big lake; a great number of people or things gathering together; a surname

 Tián

填 fill , fill in

 Tián hǎi

填海 fill up the sea , reclaim from the sea.

 Jīng wèi tián hǎi

精卫填海

The bird Jingwei fill up the sea with pebbles

 Tā dài biǎo zhe rén lèi duì zì rán mìng yùn de kàng zhēng ,xiàng zhēng zhe miàn duì mó nàn ,yǒng bù qū fú de jīng shén

它代表着人类对自然命运的抗争,象征着面对磨难，永不屈服的精神

It represents the struggle of human beings against the fate and nature, and symbolizes the spirit of never giving in to suffering

 Yú gōng yí shān

愚公移山

The Foolish Old Man try to remove the mountains

 .....

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wjw [go away. peasant. gif] to cf i think. hopefully when she has no reason to be that arrogant or smug

she's wan jingwei she kind of has every reason to be arrogant AND smug because she's in a position of real power 😭😭😭 (EXCEPT when I decide to take her down a peg ahahhah) i can make her look at him like he's a little rat under her foot?

she DOES have a terrible habit of flicking her hand that's her Go Away Peasant .gif moment

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my liege... (coughs as the heart monitor skips a beat).... give us a cao fen and wan jingwei interaction.... please....

funny you say this while I'm writing the ONLY chapters (aside from 1 reverie) where they are actually in the same room at all LOL I'll see what I can do but I don't think they're gonna talk 😳