#In the public interest

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[breadandblankets]

au where the bats manage to stay urban legends, sure other heroes know of them, but they help largely from the shadows, they aren't put on display and they're hardly known at All outside of the strange circle of gotham's goons

that changes when duke thomas stares batman down and says on no uncertain terms that he's working day shift

the signal is Gotham's first confirmed superhero, and he wears a bat on his chest

social media goes Wild fighting over whether the Batman existed all along or if someone finally got the tech and powers to make the bat (or a bat) Real

suddenly the world of superheros feels a lot more real to the citizens of Gotham who got used to horrible disasters being either ignored or neatly cleaned away from the public eye, now there's a guy getting thrown through windows and helping grannies cross the street and the war between gotham and metropolis gets even more cut throat

[thebreakfastgod]

America's Roads: Dangerous by Design

[bunnieswithknives]

AU based off Nature except I kept thinking about it too hard. Dales not a good dad, but its such an easy problem for him to throw money at, and what do you do when a part is damaged? Well, you replace it.

Basically an AU where Dev gets to experience medical trauma and realizes much sooner how much his dad doesn't love him

[raepliica]

priest guy sending mixed signals, what is he up to?🤨🕶🤏

~~~

[Image Description: A warm-toned comic featuring Trigun98 characters. It opens with Vash shouting "YOWCH!!" as a half-eaten donut flies through the air, a bruise on Vash's tongue. Meryl, editing papers, is annoyed as he complains: "Ow! Ow! I bi'e my 'ongue..." "What's the rush?" Meryl asks, "They're all yours." Vash, still hurt, tries to explain: "They're jus' sooo good!" Meryl argues back, "Well, savour it then!" Wolfwood has been watching the scene unfold as Meryl continues, "Satisfying your sweet tooth doesn't come cheap, unfortunately." Wolfwood clicks his lighter open and closed, again and again. Without a word, he leans closer, his thumb on Vash's lips. "Wolfwood...?" Vash trails off. Then, Wolfwood opens Vash's mouth and knicks his thumb on one of Vash's canines in one fell swoop. "Wah? Huh??" Vash says as Wolfwood pulls his bleeding thumb away. He licks the blood off the wound then snickers at Vash. Meryl looks disgusted, Vash has lit up in an embarrassed explosion, and Milly remarks, curious: "Those are surprisingly sharp, Mr. Vash!" Question marks float around Vash, and his donuts lay discarded on the table. Each panel is signed by raepliica. End ID]

[taffywabbit]

so like. at what point are we going to stop listening to game companies saying "the game was poorly received and didn't meet our sales targets, and that's why we're removing it from storefronts and taking down all the servers mere months or even weeks after release" for titles that had a long expensive development, were barely marketed, and nobody knew they'd even released until after they heard they were getting shut down and couldn't be played/purchased anymore?

I feel like the prevailing takeaway for anyone who doesn't just conclude "yeah, game was pretty mid, makes sense to me" has usually been "this company just has unreasonably impossible sales expectations and treats every project like a failure if it doesn't print a trillion dollars". but these ARE allegedly experienced business execs who aren't complete idiots, and after this most recent debacle with Concord I'm starting to wonder if a bunch of these "games getting wiped out of existence when they underperform instead of just being allowed to persist as they are and maybe improve with time" cases in recent years might be more of a Warner-Discovery type situation, like nuking an entire animated series or film that was worked on for years and preventing it from being sold because it has to be officially unprofitable for the company to use it as a tax write-off. I look at a game that was worked on for 8 years and only made available for 2 weeks, and it's hard not to see the parallels.

great work, AAA games industry, really normal and sustainable stuff you're doing over there as usual

[qwantzfeed]

ceci n'est pas une pipe?  more like ceci n'est pas une intellectual property crime in just a few months and honestly, i hate to wait

[14dayswithyou]

💖 EVEN MORE DAY 4 SNEAK PEEKS! 💖

[cyanbeetle]

My Wonder Woman and friends

[biggest-gaudiest-patronuses]

there's just... there is no reason to make yet another cop show in this day and age. copaganda is not only bullshit, it is a failure of imagination.

you want to watch brooding characters with dark pasts investigate crimes in an official capacity? just use private detectives (cops have a miserable solve rate anyway). want eccentric geniuses & their sidekicks solving mysteries? i present you with armchair detectives & neighborhood busybodies. oh, you're craving a workplace comedy-drama starring overworked protagonists doing their heartfelt best to resolve community conflicts? social worker office sitcom! bitch this is ACHIEVABLE

[littlecrittereli]

Hey there! I read both Reprogrammed and Decoded and was blown away. Unfortunately (sorta), my odd little brain had one little question that was burning from the end of Reprogrammed till the end of the story: what about the Wild Kratts Kids? How did they react to Chris's disappearance/return? I know if I were 8 and my teacher (i guess thats an okay metaphor? maybe?) randomly disappeared for 3 months and came back 10 pounds lighter with dozens of new scars and white hair in their early twenties, I'd be a little torn up/curious. How would Chris feel about showing up on screen in front of a bunch of kids in his state? Would he...wear a...hat...or something...? I don't know, just thoughts lol

They never told the public that Chris was missing (Didn't wanna scare the kids or give the Villains the knowledge that they were vulnerable)

And being out in the most rural parts of the world, it's not uncommon for them to go months without any sort of public appearance. For now, Martin is handling any sort of press alone until Chris is ready to be back in the public eye.

But of course they still run into a wild kratts kid every once and a while.

He's still working on his alibi.....

[hellsitegenetics]

https://scp-wiki.wikidot.com/scp-3999

String identified: SCP-3999 Object Class: Apollyon Special Containment Procedures: SCP-3999 cannot be contained stop be contained

String identified: Item #:

String identified: Researcher Talloran:

Closest match: Trametes ferrium Common name: Metal eating fungus.

Researcher Talloran is to be identified using the BLAST database modeled using AlphaFold kept in a standard terrarium suitable for moths.

Common name: finding tumblr's genome one post at a time.

String identified: The following file contains a virulent infohazard. Due to this, it is imperative that all personnel accessing this file be certified as having a Cognitive Resistance Value (CRV) of no less than 14.5. Should you fail an automated CRV verification, please remain calm and do not move. A member of your site's medical staff Researcher Talloran will be with you shortly.

Special Containment Procedures: Researcher Talloran is to have his genome aligned with its 12 closest genetic matches using MEGA. Navigate to the "table" section and select phylogenetic tree. Click "yes." Use sub-branches to note connections between each branch, such as families or kingdoms.

Item #: Cydia strobilella genome assembly, chromosome: Z Object Class: Spruce seed moth

(Researcher Talloran must link the image source.) This can be the only conclusive fact.

So stop asking.

[alwaysbewoke]

[wickerfemme]

Lots of good reasons to get fat, but one of them is to become better and more comfortable for girls to nap on you

[decarabias]

underrated part of mementos mission is ren being so effortlessly pretty that the casting director at ann’s photoshoot thinks he’s one of the models

i know he demurs in response but i do still like it as an unconventional postcanon career for him because first of all his face card never declines

but also it is deeply fun to think of akechi with a password protected folder on his phone with all of ren’s horniest photoshoots

[the-judicial-assistants-notebook]

not enough discussion about the gavins' complicated relationship with feminine-coded/beauty products, i don't think.