#I was reading a paper on the economics of our pharmaceutical industry and. it’s so fucking dumb.

[meteortrails]

holy fuck I love how petty and aggressive academics are. imagine talking to your colleague and being like ‘yeah actually I think your work delegitimizes our entire field and is so wildly ineffective it would sterilize an entire country’s economy if you put it into practice bc it’s just that fucking stupid. kys.’ like go girl go!!!

[taylorscottbarnett]

“10 ominous and risky trend”

Nah. First you only list nine. One is basically listed twice.

Ok so this is my issue with this analysis, we have the attention grabber: “Called the 2008 Crash” however some form of recession usually hits every decade or so. Let us take a look at the predictions that didn’t pan out (and still haven't):

He predicted that foreign investors would stop financing the fiscal and current-account deficit and abandon the dollar, wreaking havoc on the economy. He said that these problems, which he called the “twin financial train wrecks,” might manifest themselves in 2005 or, at the latest, 2006. “You have been warned here first,” he wrote ominously on his blog. But by the end of 2006, the train wrecks hadn’t occurred.

Note, the economy may have crashed, but it had zero to do with foreign investors not financing debt. Throughout the economic crisis and the decade that followed, countries bought up US Debt like it was hand sanitizer and paper towels at the start of the COVID crisis.  The world has also weathered the Greek debt crisis as well as the Italy’s issues, and Brexit with not much crisis to show for it, and what did happen was mostly temporary for the world economy. People have been issuing warnings about the aging crisis for decades, but it is not as hard to solve (for the US) as people assume. Yes social security, and medicare taxes and increasing intensives for companies and people to invest in saving for the future need to be increased. However, America’s aging workforce has two silver bullets: One, automation. In some estimates nearly have of all jobs can be automated in the next decade -- while that has it’s own set of issues, a worker shortage isn’t one of them. Secondly, as I’ve stated before, immigration reform would go a long way towards shoring up the US’ older workforce. The later comes with new workers contributing social security and medicare taxes to public coffers. The former can be taxed the same, just with new tax systems.

Let’s take a look at some of the issues he has declared the reason we are all doomed:

A third issue is the growing risk of deflation. In addition to causing a deep recession, the crisis is also creating a massive slack in goods (unused machines and capacity) and labour markets (mass unemployment), as well as driving a price collapse in commodities such as oil and industrial metals. That makes debt deflation likely, increasing the risk of insolvency.

Hey look while Republicans supposedly feared inflation when we were fighting the 2007-2008 financial crisis (one that I’ll remind you never occurred) and economists stated wouldn’t occur. Paul Krugman spent years warning about over-hyped inflation worries by policy makers.:

Recently the Federal Reserve released transcripts of its monetary policy meetings during the fateful year of 2008. And boy, are they discouraging reading. ... The economy was plunging, yet all many people at the Fed wanted to talk about was inflation. ... 

As I suggested, we used to marvel at the wrongheadedness of policy makers during the Great Depression. But when the Great Recession struck, and we were given a chance to do better, we ended up repeating all the same mistakes.

But Republicans were up in arms, warning that the Fed’s policies would lead to runaway inflation. A Congressman named Mike Pence introduced a bill that would prohibit the Fed from even considering the state of the labor market in its actions. A who’s who of Republicans signed an open letter to Ben Bernanke demanding that he stop his monetary efforts, which they claimed would “risk currency debasement and inflation.”

Bernanke, Fed economists, and Keynesians in general were proved right: printing money isn’t inflationary in a depressed economy.

Needless to say, those warnings proved totally wrong. Soaring inflation never materialized. Job creation was sluggish at first, but more recently has accelerated dramatically.

K so let us move on to other issues shall we?

A fifth issue is the broader digital disruption of the economy. With millions of people losing their jobs or working and earning less, the income and wealth gaps of the 21st-century economy will widen further. To guard against future supply-chain shocks, companies in advanced economies will re-shore production from low-cost regions to higher-cost domestic markets. But rather than helping workers at home, this trend will accelerate the pace of automation, putting downward pressure on wages and further fanning the flames of populism, nationalism, and xenophobia.

Again, Automation is inevitable, and as I said earlier, a benefit and solution to an ageing workforce. One should also note this crisis has also been talked about for decades. It still never happened. Although many jobs have been automated, more jobs tend to come in and take the place of those lost jobs. Sectors of the economy die all the time. They get replaced. Automation isn’t going to necessarily be the death of the American worker -- if anything working less wouldn’t hurt us. There is a valid argument if you look at many of our peers, the American worker is overworked already.

This points to the sixth major factor: deglobalisation. The pandemic is accelerating trends toward balkanisation and fragmentation that were already well underway. The US and China will decouple faster, and most countries will respond by adopting still more protectionist policies to shield domestic firms and workers from global disruptions. The post-pandemic world will be marked by tighter restrictions on the movement of goods, services, capital, labour, technology, data, and information. This is already happening in the pharmaceutical, medical-equipment, and food sectors, where governments are imposing export restrictions and other protectionist measures in response to the crisis. 

True, at the moment populism has had a nice multi-year run. de-globalization has been a goal of Donald Trump for his entire presidency. Trump will not be president forever. As our current COVID crisis has illustrated, he really is a carnival barker, and if anything has increased the odds of Biden becoming president and they were already pretty damn likely.

Under conditions of heightened economic insecurity, there will be a strong impulse to scapegoat foreigners for the crisis. Blue-collar workers and broad cohorts of the middle class will become more susceptible to populist rhetoric, particularly proposals to restrict migration and trade.

Again, this already happened with the election of Donald Trump. But take a look at just how close many of those state elections came: Michigan, Wisconsin, Florida and Pennsylvania --  A flu (and this would have been an illness far less destructive than COVID) could have affected the outcomes of those states -- and the election. A few thousand votes in a country that cast 138,884,643 ballots and had another  92,671,979 that could have voted but didn't won Trump the election.

This points to an eighth factor: the geostrategic standoff between the US and China. With the Trump administration making every effort to blame China for the pandemic, Chinese President Xi Jinping’s regime will double down on its claim that the US is conspiring to prevent China’s peaceful rise. The Sino-American decoupling in trade, technology, investment, data, and monetary arrangements will intensify.

Re-read my above two responses.

A final risk that cannot be ignored is environmental disruption, which, as the Covid-19 crisis has shown, can wreak far more economic havoc than a financial crisis. Recurring epidemics (HIV since the 1980s, Sars in 2003, H1N1 in 2009, Mers in 2011, Ebola in 2014-16) are, like climate change, essentially manmade disasters, born of poor health and sanitary standards, the abuse of natural systems, and the growing interconnectivity of a globalised world. Pandemics and the many morbid symptoms of climate change will become more frequent, severe, and costly in the years ahead. 

Arguably COVID closings around the world and shelter-at-home orders have if anything given the world a chance to take a breath. Also if you are arguing a globalized world is a direct reason a pandemic like this will “become more frequent, severe, and costly” then wouldn’t it stand to reason de-globalization (that you claim will happen as a result of this pandemic) would make these event’s less likely to happen in the future? Which is it? It cannot be both.

Also am I missing something or do I not find a “seventh factor” in your post at all?

[berniesrevolution]

The game of Monopoly was originally quite different when it was first patented in 1904 by a progressive woman named Lizzie Magie. Magie’s game, called “The Landlord’s Game,” was like the version you grew up playing, in that it could be won by accruing as many land lots, properties, and cash as possible. But her version came with a twist. At any time, the players could choose a more egalitarian future by voting in the Single Tax rules.

Once activated, the Single Tax required players to redirect all fines and rents on empty lots into the Public Treasury’s coffers. For any player to erect properties or collect a fine on an existing property, the Treasury first had to receive rent on the land. These public funds paid for public utilities, transportation, and college, which then became available to everyone for free. Residual funds were redistributed as higher wages for everyone. No individual could really win the Single Tax game, other than by collaborating to break up all monopolies.

Magie admired the radical philosopher Henry George, and hoped the Single Tax rules would educate players of all ages about his proposal for common land ownership. These calls for bold reforms emerged from anxieties of the first Gilded Age. Magie and George had lived through an era marked by rapid economic growth, deep inequality, political corruption, and sprawling industry trusts controlled by a few men. The status quo seemed unsustainable. If this sounds familiar, it’s because our own Gilded Age has all the symptoms of the first.

In Capital in the Twenty-First Century, the economist Thomas Piketty attributes the spike in American inequality to an imbalanced distribution of the national income. By national income, Piketty means the sum of labor income (the wages earned by workers) and capital income (the earnings from physical assets like houses and factories, and financial assets like investment accounts and corporate profits). Much like the first Gilded Age, advances in technology have magnified American productivity. We become better at creating and selling more stuff and in turn, our pie of national income grows larger. The problem is that since the 1970s, the slice of income going to workers has not kept up with their share of contribution.

The statistics are depressingly familiar. Today, the richest one percent controls 40 percent of the country’s wealth and about 90 percent of all income gains. Inheritances and other intra-familial transfers of assets explain some of this phenomenon. That so few families have so much to pass on certainly contributes to inequality. But patrimony alone cannot account for how aggressively the owners of capital have been able to commandeer more than their fair share. To understand this rapid concentration of wealth and income, we must also consider the metastasis of corporations into colossal trusts, happening at the same time as the government shirks its duty to protect consumers and workers.

The year 2015 alone saw a reported 4.7 trillion dollars’ worth of merger and acquisition deals. Chemical companies Dow Chemical merged with DuPont and on the food side, Kraft and Heinz became one. Two years later, Amazon purchased the Whole Foods chain, while the CVS pharmacy brand acquired the insurer Aetna. In 2018, the pharmaceutical firm Bayer is taking over the agricultural giant Monsanto in a 62 billion dollar deal. Year after year, thousands of firms across the economy swallow their competitors or other businesses in the supply chain to control more of their market.

But should we actually care about the unions of these corporate leviathans any more than we do about royal weddings? With our economy controlled by tangles of subsidiaries and shell companies anchored in exotic locales, keeping score of who owns whom seems like a futile effort. Corporate names and logos blur together in a sea of deals reported only in the most boring articles for only the most boring lawyers. For at least a while, our food tastes the same; our prescriptions cost the same; our quality of service seems the same. So we sit like frogs in a pot of simmering water, undisturbed by the aggressive consolidations of corporate power around us. By the time we notice the changes, it’s often too late.

The common wisdom is that, in a fair economy, market competition fosters innovation as firms attempt to build on each other’s advances. It also leads to higher quality, lower prices, and better deals for consumers, workers, and other producers in the supply chain. Firms that wish to thrive and grow are supposed to cultivate their relations with all these stakeholders, or risk losing them to competitors. An economy where firms possess too much market power breeds opposite conditions.

In a series of papers on this subject, the economist Marshall Steinbaum describes market power as a “concentration and substantial power” that allows firms to “skew market outcomes in [their] interest, without creating value or serving the public good.” In other words: The more powerful a firm becomes, the more it can crush stakeholders and competitors without consequences. This is true of monopolies—when a producer has exclusive control over the supply of a product or service—but it really extends to any firm with concentrated market power.

The menu of “crushing” options at their disposal is quite diverse. Generally though, they fall in the categories of consolidation, barriers to entry, and a broader set of anticompetitive behavior. The larger that firms become, the easier they can increase their control of the market. The recent deals illustrate just how frequently corporations with a lot of market power consolidate with their competitors. After the purchase is complete, firms can integrate the new acquisition into their brand. Sometimes, they simply maintain the purchase as a separate subsidiary though the consolidation gives them much less reason to vigorously compete with each other. In other cases yet, the firm might shut down the new purchase forever.

Consolidation can double as a barrier to entry when the absorbed company is a startup that could have or supported or even become another competitor. But there are other types of barriers. Patents give the holder an exclusive and enforceable right to supply a product for many years, even if this monopoly of use could hurt society at large. Then there are refusals-to-deal agreements—where firms conspire to do business with an exclusive list of companies—which more subtly cripple young businesses trying to enter a market.

(Continue Reading)

[blog-cosmosuniverse1]

Patents Prove COVID Fraud and Illegal Dealings

In the early 2000s, David Martin, Ph.D., founder of M-CAM International, started finding large numbers of patents that violate biological and chemical weapons laws In 1999, Dr. Anthony Fauci funded research to create “an infectious replication-defective recombinant coronavirus.” In 2002, Ralph Baric, Ph.D. and colleagues at the University of North Carolina, Chapel Hill, filed a patent on recombinant coronavirus, and within a year, we got the world’s first SARS outbreak Since 1999, at least 4,000 patents involving coronavirus have been filed, including patents detailing key features of the so-called “novel” SARS-CoV-2 virus The 2001 anthrax attack, which came out of medical and defense research, led to the passage of the PREP Act, which removed liability for manufacturers of emergency medical countermeasures The funds for entitlement programs and pensions will dry up by 2028, at which point the drug industry will go bankrupt as well. With a burgeoning population that is sick from the COVID jabs, we need to prepare new systems to care for each other

In this interview, we continue our coverage of the COVID “plandemic” by speaking to David Martin, Ph.D., who has done a phenomenal job uncovering the paper trail behind the virus now known as SARS-CoV-2. As it turns out, this is not a novel virus at all, as patents and government grants detailing key features of the virus go back two decades.Martin finished his doctorate at the University of Virginia in 1995, after which he was hired on to the medical school faculty in radiology and orthopedic surgery. In 2006, he set up the first medical device clinical trials organization for the University of Virginia — a company called IDEAmed — which conducted medical device clinical trials for U.S. Food and Drug Administration submission. So, he has an extensive background working with FDA clinical trials.Monitoring Biological Weapons Violations In 1998, he founded another company called M-CAM International, which is focused on finding ways to bring intellectual property into conventional finance. M-CAM also started auditing the U.S. patent system at the request of the U.S. Congress.In the early 2000s, M-CAM worked with the Senate Banking Committee and was a contractor for the United States Treasury to expose white collar criminal activity around intellectual property and tax fraud. In doing that work, Martin also discovered something else.“Quite alarmingly, we found an enormous number of patents [detailing] biological and chemical weapon violations,” Martin says. “That was not something we were looking for. I let people know this was not something we set out to find. This is something that landed in our lap. I developed a technology a decade earlier called linguistic genomics, which is a means by which you can look at unstructured text data and find the metaphoric meaning inside of what is being communicated. As you can imagine, if people of ill intent are trying to do something, they often hide what they're doing in plain sight, but they use language that is not conventional.So, when you find a patent, for example, on a blast-resistant pathogen from a rocket-propelled grenade — did you hear what I just said? ‘A blast-resistant pathogen from a rocket-propelled grenade.’ Does that sound like it's a common way to inoculate a population or does that sound like [a bioweapon]?And so, finding a number of bioweapons patents, we started taking into account some very serious things. I published once a year the literal global phonebook of every biological and chemical weapon violation that took place anywhere in the world.[It tells you] the who, the where, the who funded it, what their addresses are. It was … used by U.S. law enforcement, intelligence communities and elsewhere around the world to track things that were being done inappropriately. And, it was in 1999 [that] we started detecting that there seemed to be an alarming event around coronavirus, which we're going to get into.”Coronavirus Identified as a Potential Vaccine Vector As explained by Martin, in 1999, the National Institutes of Allergy and Infectious Diseases (NIAID), headed by Dr. Anthony Fauci, identified coronavirus as a possible vaccine vector.At the time, the disclosed rationale was to try to come up with an HIV vaccine, and to that end, Fauci, in 1999, funded research to create “an infectious replication-defective recombinant coronavirus.”In 2002, Ralph Baric, Ph.D. and colleagues at the University of North Carolina, Chapel Hill, filed a patent on recombinant coronavirus, and within a year, we got the world’s first SARS outbreak. The Real Tony Fauci For more background on Fauci, be sure to read Robert F. Kennedy Jr.’s book “The Real Tony Fauci,” which details how Fauci’s promotion of AZT during the 1980s ended up killing hundreds of thousands of people. And the pattern we’re seeing with coronavirus is basically a repeat of previous behavior. Martin says:“It’s important to realize that at the time [in 1984 when Fauci became director of the NIAID] we were transitioning from an STD environment in which syphilis and

gonorrhea and those types of STDs were the things that we were concerned about …HIV became a political and social hot potato because it was associated in many respects with lifestyle branding, and as a result it became a political issue to essentially identify a class of the population that could be the basis for research without consideration.The notion by Fauci was that people with HIV had already made decisions that somehow entitled them to less humanity. As a result, the clinical trials around developing both management techniques as well as potential treatments … were done in a very reckless fashion. Numerous people died in [those] clinical trials, and by the way, still are …He has been obsessed about this HIV situation as a platform to, essentially, use humans that he determines to be some form of sub-human for clinical trials. It is a horrific blight on the United States’ medical establishment that we have been willing to allow this to go on in the name of science, in the name of health promotion, since 1984, without any significant disruption or check.”The First SARS Outbreak The first SARS outbreak occurred in late 2002 going into 2003 in China. Curiously, before Baric’s team invented and patented a recombinant infectious replication-defective coronavirus, no one had ever heard of SARS.“I'm not drawing a causal relationship,” Martin says. “I'm making an observation that humans and what we call coronavirus seem to have cohabitated this earth for hundreds of thousands of years.And then we manipulate that [virus] in 1999. We start playing around with putting it into different animals and different human cell line models, and then in 2003, we have SARS. Like a lot of other things, it's an observation worth noting.What makes the observation more problematic, obviously, is this was happening during the unfortunate results of the 2001 anthrax attack, which as you know came out of federal labs …[It] became very clear that this was not [due to] a bad actor, per se. This was medical and defense research gone bad that got into the public and people died. But the real benefit, if you will, of the anthrax attack was the passage of the PREP Act.”Anthrax Attack Provided Desired Liability Removal Inside the PREP Act we now have the carte blanche removal of liability for manufacturers of medical countermeasures. As noted by Martin, the PREP Act has “made pharmaceutical companies much more capable of instilling terror in the population, coercing a population into taking an untested measure, and doing so with absolute impunity.”Curiously, while Martin’s annual report on bioweapons patents was, with only a few exceptions, appreciated and used by agencies around the world, when it comes to the information he has amassed on coronavirus, not a single agency anywhere in the world has been willing to address it.“No one … seems to be willing to look at the fact that beginning in 2016 we started seeing very alarming language being used, which was ‘coronavirus poised for human emergence.’ This was in patents, but also in scientific publications. And when you start referring to a coronavirus allegedly poised for human emergence, after the World Health Organization has declared SARS eradicated, there's something desperately wrong with that picture.”Racketeering and Organized Crime The biggest alarm bell was published February 12, 2016, by EcoHealth Alliance president Peter Daszak1 who, according to Martin, has been “the money laundering agent” for gain-of-function research coronaviruses after the U.S. implemented a moratorium on that kind of research in 2014. Rather than close it down, this research was simply moved over to China instead. In 2015, Daszak stated:2"To sustain the funding base beyond the crisis, we need to increase the public understanding of the need for medical countermeasures, such as a pan influenza or a pan coronavirus vaccine. A key driver is the media and the economics will follow the hype. We need to use that hype to our advantage to get to the real issues. Investors

will respond if they see profit at the end of the process."That statement was made by Daszak in 2015, and was published in the spring of 2016. The statement “set off alarm bells very loudly within my organization,” Martin says, “because when you have somebody who is promoting gain-of-function research, and clearly blurring the line on what is even legal … saying we need ‘media to create the hype’ … and ‘investors will follow if they see profit’ … that doesn't sound like public health.To me, that sounds like organized crime. That sounds like racketeering, and we need to raise this issue.”What the Coronavirus Patents Show In all, since 2002, some 4,000 patents have been filed on the genome, vaccines and detection of coronavirus. According to Martin, this is alarming, “because you don't file patents on something that you don't intend to commercialize.” Evidence of intended commercialization can also be found by looking at the dates of certain patents by certain companies.April 28, 2003, the U.S. Centers for Disease Control and Prevention filed a patent on the genome of the SARS coronavirus. Five days later, Sequoia Pharmaceuticals received a $935,000 grant and filed U.S. Patent 7151163 for a treatment for that same virus. How can you file a patent for the treatment of a virus that was only discovered five days earlier?“That sounds like an inside job,” Martin says. “Because you cannot have a pathogen identified and a cure for it in five days, when all of the information was held from the public, because when the CDC filed its patent on the genome of coronavirus, it paid to keep that patent secret.So, somebody somewhere knows that this thing was going to turn out to be a moneymaker … The proliferation of proprietary controls around SARS Coronavirus probably exceeds at least by two or three times most other pathogens …Dana Farber had a monoclonal antibody patent system that came out of three NIH grants. Their patent 7750123 on the monoclonal antibody for SARS-Cov treatment took place in 2003.”So, while we’ve been told that SARS-CoV-2 is something we’ve never seen before, there are 4,000 patents and patent applications that say otherwise. The same can be said for the testing and the COVID shots. For example, Pfizer filed the first S1 spike protein vaccine patent on coronavirus in 1990 — 30 years ago.“Regardless of what part of the story we look at, the patent record is full of thousands of patents where commercial interests funded by NIAID and the National Institutes of Health have been building the economic cabal around coronavirus. This is not a new thing. It hasn't been a new thing.And regrettably, we're being told continuously that somehow or another there's something novel about this experience, despite the fact that every single part of what we are told is being detected with PCR … the injections, every single one of those things has been known and isolated for over 30 years.”How Did We Get Here? How did we get to a point where taxpayers are funding research on pathogens that are being designed to sicken and kill us, only to drive profits into the drug industry and all these various patent holders, which include the government itself?In large part, it goes back to the implementation of the Bayh-Dole Act of 1980, which allows the beneficiaries of federal grants to file patents on work derived from federally funded research. The idea was that the economy would benefit by allowing scientists to be entrepreneurs first, rather than simply publishing their research.This piece of legislation has undermined health care by bringing the patent office, the FDA and CDC into an unholy trinity that serves and promotes private pharmaceutical concerns. So, what we have now is an insidious funding loop. Martin explains:“Corporations and pharma lobby to get people elected. Once they're elected, the lobbyists flow an enormous amount of money into the various NIH programs. In the case of NIAID, since Fauci took over [in 1984], $191 billion have gone through his fingers. Now, is that because

he's successful?No, as a matter of fact, under his watch, allergies and infectious diseases have increased over 60 times. Yet somehow or another, he's still the director of a failed [agency] that's gotten $191 billion to solve a problem that is getting worse every single year.If it was a company, we would have fired him. The problem is, it's not a company. It’s a money laundering agency. It moves public funds through the hands of a federal agency into the research laboratories, which ultimately are going to conduct research that is then licensed back to the benefactors, which are the pharmaceutical companies that paid to get people into office in the first place.So, this is a revolving door problem, and the Bayh-Dole Act created an insidious incentive that said that the only research that was going to be conducted was going to be research that ultimately would flow back to the pharmaceutical industry and create juggernauts, where the risk of R&D was taken by the public and the benefit for that R&D was taken by the private. That's a horrible thing, and that is exactly what Fauci has run.”Why Did Fauci Pick Moderna as Vaccine Frontrunner? Martin also points out that Fauci has also lied to Congress about the NIAID’s financial interests in drugs. During this pandemic, Congress and the Congressional Budget Office asked for an accounting of NIH-owned patents where they have potential commercial interest in the drugs being produced. Fauci did not disclose any of them. Instead he lied and said there are none.“The evidence is stacked a mile long,” Martin says. “Moderna stands alone as the only recipient of NIAID funding that fails to comply with the law and fails to disclose the federal government’s interest in their intellectual property.Despite the fact that everyone knew Moderna failed to disclose the federal government’s interest in its research, Fauci picked Moderna to be the frontrunner for an untested, commercially unsuccessful and entirely unproven mRNA vaccine technology in the spring of 2020.There was no rational justification for that, and there would have been less rational justification, given the fact that Moderna is on record as having violated the federal law, the Bayh-Dole Act, 141 times at the time they were picked to be the winner.This is a known fact, but it was overlooked entirely, and not a single law enforcement agent anywhere in the United States has decided that having a criminal organization supply a product sounds like a bad idea.”Violations of Law Everywhere Since the beginning of this pandemic, the number of rules, laws and regulations that have been broken in the name of public health boggle the mind. Even laws that are absolutely clear and in no way ambiguous are being broken. For example, under Code of Federal Regulations Title 21, section 50, no one can be forced or coerced into a clinical trial of an experimental medical product, even if it’s a pandemic countermeasure.“It's black and white, and this clinical trial does not end until 2023 in the first best instance. So, there is no such thing as an approved or even authorized use of a [COVID ‘vaccine’] that can be compelled on the population,” Martin says.And yet they’re bribing, threatening and coercing people everywhere. The drug companies also violated basic principles by eliminating all of the controls and giving the test vaccine to everyone in the trials, leaving us nothing against which to compare side effects. They also do not have an independent investigational review board, or the statutorily required approval processes for the protocol.The companies themselves decided to modify their protocols midstream, which simply isn’t how it’s done. Basically, we do not have an actual clinical trial on these COVID shots, because so many of the basic principles of clinical medical research were violated.Collapsed Judicial System Has Put Big Pharma in Charge The federal government is also violating the False Claims Act by telling you the COVID shots are safe and effective, when the studies are still

years from being completed, and have been undermined in all the ways just mentioned.“What we have is a situation where the deaths are actually considered to be acceptable,” Martin says. “I don't know what world you have to come from to find that term even remotely speakable. I think the utterance of that phrase is horrific … We are killing people willfully, and we are doing it with impunity in the name of what we call a love affair with science.The only problem is we've desecrated science in the process because it turns out that when I did randomized double-blind, placebo-controlled trials, you know what I had to do? I had to keep the populations blinded. I had to keep it placebo-controlled for the whole clinical trial. And the reason I had to do that is because that's what the statute requires.This entire process has been willful acts of harm to humanity. And the only hope we have is a very small note in the Department of Justice opinion that took place under the Trump administration, which says that if this was based on felony acts, then the entire emergency use authorization and all its benefits would collapse.In other words, if we can show that a felony has occurred — racketeering, lying to Congress, the public coercion … [and] in the Fauci dossier3 I outline dozens of felony violations — [it] would bring this entire thing to its knees, because the moment the PREP Act protection falls away from Pfizer, Moderna, Johnson & Johnson, AstraZeneca and others, I can guarantee you [Fauci] will not be promoting a vaccine.If they are liable for a single injury or death, they'll pull the plug on what they know to be unsafe. That requires law enforcement to do its job. And somewhere there has to be a prosecutor who's willing to do their job … Right now, I genuinely do not think we have three tiers of government. I don't think there is a Department of Justice.The judiciary is functionally gone … When we allow the judiciary to be an arm of the executive [branch], then what happens is we've actually lost the three-tiered structure of government. And, as a result, the system collapses. The judiciary was the only thing that was explicitly independent. We don't allow judges to get sponsorship in campaign finance. We don't allow judges to be elected.We appoint them, we go through an approval process. We do all sorts of things to try to make sure the judiciary is independent. So, the only risk to the pharmaceutical industry, the only risk to an executive out of control, was the judiciary.By collapsing the judicial system in the United States, we have effectively made the government a servant of its benefactors — and that is the pharmaceutical industry.”How Will It End? With what appears to be a near-total collapse of the judicial system, it looks like we’re on a straight path to global tyranny, with no routes of escape. Martin, however, believes there may be a way out, but it will require action on behalf of rational individuals blessed with foresight. He explains:“You have to have currency to buy off politicians. Back in 2008, when we had the global financial crisis… we instituted a policy that [will] functionally bankrupt our entitlement program (Social Security, Medicare and Medicaid) in 2028 [or 2033] …The best math we have is that the annuities and pension programs of the United States functionally run out of their trust fund in 2028. What does that mean? Well, one of the things that people overlook is there's an unholy alliance between the insurance companies and what we call health care.Insurance companies are long-dated asset holders. These are the people who have to have money today to cover issues in the future. That's what a long-dated asset holder is. The problem is that the Federal Reserve and the European Central Bank and other central banks have suppressed the value of the return on funds, so the funds are running out of money faster than expected …You know as well as anybody else that for a politician to stand up and say, ‘I'm going to abolish or significantly alter

Social Security’ is the death knell to any political aspiration. Tiny problem. But whether they say it or not, the trust fund runs out of money in 2028.Now, here comes the kicker: So does the pharmaceutical industry because it turns out that the money that's going into that system is actually paying for the drug dependency of this country.And if we go all the way back to 1604 — to the establishment of the British East India Company and the establishment of the Virginia Company — we'll realize that the 400-plus-year tradition that we have, where we have built nation states on the back of the drug trade, is coming to its end.The good news for all of us is it's going to end around 2028, because we have a convergence that they didn't figure out how to cover up. The convergence is that the people with the money, the big pharmaceutical players, are the beneficiaries of a system that is going to bankrupt itself by virtue of their actions.This is the brontosaurus that ate too much because it was the biggest dinosaur. And the great news is they have the brain the size of a pea, just like the brontosaurus. They are not smart. And the best thing we have going for us furry humans is that we actually are nimble.Now, does that mean that we are not going to have an ounce of pain through the process? Absolutely not. There is social disruption that we can't even imagine on the horizon in 2026, 2027 and 2028, because 86 million people will lose what they thought was going to be their retirement funds.When we see that number now go to 100 million people, and the 100 million people are sicker because of what we've injected today … those people who are going to require greater health care then are going to be faced with a bankrupt system incapable of supporting their life and their livelihood. And that is the death knell of this story.The best news about this is we have time if people of good conscience get together and say, ‘We're not going to let that apocalypse arrive because we have time to start building communities that actually care for each other. We have time to start building accountability structures.We have time to start doing things that bring our social fabric together so that when that system collapses, we can come back to a rational view of what life and liberty and the pursuit of happiness is’ because, until we can reclaim the sovereignty of our health, we cannot celebrate the sovereignty of our life.”What About the 2030 Agenda? By now, you’ve probably heard of the World Economic Forum’s Great Reset agenda, which includes the transition to a Central Bank Digital Currency. With that, they can abolish the dollar and “reset” the entire global economy that is now tottering on its last leg. However, even here there may be kink in the plan that can save us.“Like a good [James] Bond villain, he's actually ignorant of history,” Martin says. The reason Martin remains optimistic that the Great Reset doesn't have a chance at all to succeed is because there’s no way the global public will embrace an all-digital system that can be annihilated by an electromagnetic pulse or electromagnetic disruption.This year alone, we’ve seen internet failures, power outages and digital finance hacks that would leave people stranded without a single penny were they reliant on an all-digital financial system.“The digital currency illusion is the most bizarre and pathetic Dr. Evil plan anybody's ever concocted,” Martin says. “The fact of the matter is the digital currency craze is one of those fantastical illusions that unfortunately has a single-point failure.We live in a world where actors of both anarchist intent, and very, very laudable privateers and pirates are more than happy to make sure that digital currency never sees the light of day because they will, in fact, hack, crack and disrupt every system out there.And so, I look at the whole Great Reset as great theater … But the entire illusion is being run because they're out of ideas. And … when the incumbency is out of bad ideas, they try

desperately to force you into a behavior that you would not otherwise accept. All you have to do is just say no. Just don't play along.”The Financial Incentive for Depopulation

Is it possible that the COVID jabs might cause premature death and be an intentional form of depopulation? Well, since we’re following the money, there’s certainly a financial incentive for such a scenario. As noted by Martin, if you’ve made financial promises to people who are closing in on retirement, the fewer there are of them the better.

“The financial interest for depopulation is a thoroughly compelling argument,” Martin says. He recently reviewed this argument in a lecture given at the Church of Glad Tidings in Yuba City, which you can view above.

In short, having people live long enough to tap into their Social Security benefits and live to the full maturity of their life insurance policies is problematic with respect to the financial collapse that is looming.

Based on these financial realities — which certainly are not advertised or publicly discussed — there’s clearly an economic incentive to shrink the population and get rid of as many people as possible before 2028. Unfortunately, based on previous lipid nanoparticle and mRNA trials, the chance of a mass casualty event is high.

“There is no question … they jumped over animal trials for a very important reason,” Martin says. “We've been told it was to save time, but it wasn't to save time.

It was to put this particular pathogen into humanity, so that a lot of people suffer and ultimately die of effects that we could have picked up if we had done it the traditional way, which is seven to eight years of safety studies, before we decide to put it in the arms of humans.

That's not what we did. And if we look at the safety data from animal studies on mRNA, and on the lipid nanoparticle, there is no question that there is going to be a fatality increase because of this …

But the concern I have, [which may be] more egregious [than] the death … is the malingering morbidity, people who will require around the clock medical care is going to be a drain that will infect our economy so deeply that we may not recover.

Because if we have people who have to stay at home with children who are sick, if we have people who have to care for elderly parents who are sick, if we have people who are caring for a spouse or a family member who are sick, that means we do not have the ability to enjoy life and liberty. And the fact is that I think we're going to have a bigger morbidity than mortality event.”

Now, as if all of that weren’t enough, Martin has also discovered CRISPR patents that describe how they can “clip” the effects of mRNA/DNA-based vaccines from people. He believes they may be building a pathogen set that is then introduced into the population so that they can later introduce a more expensive technology that can fix what was broken. This, unfortunately, could mean survival may be based on your ability to pay.

Were There Excess Deaths Due to COVID-19?

To backtrack for a moment, while we’ve been told COVID-19 caused excess deaths in 2020, one way to double-check that is to look at the number of life insurance policies paid. And in 2020, there were actually fewer life insurance policies paid out than normal, according to Martin.

“Whose numbers are you going to believe? Are you going to believe the CDC who's trying to pump and dump this terror campaign of people dying, and therefore you need to have your mask on, you need to socially distance, you need to vaccinate?

Or are you going to believe the numbers from the people who actually pay claims when real human life ends? It turns out that if you look at the audited financial statements of the world's largest life insurance companies, we can find no excess death evidence. Is COVID so smart that it only kills the uninsured? Is that what we're supposed to believe?”

Live Consciously, Aligned With Health

In closing, I, like Martin, believe we can survive this and keep our freedom. But we must act. Individually, every single person needs to take actions that are in line with pro-life and liberty morals and ethics. As suggested by Martin, spend your money on certified organic foods and locally grown foods to help build a healthier food system.

Make sure that what you put into your body is aligned to your health. Make sure that what you do with your body is aligned to your health. And then as you do that, invite other people into living a life that in fact models that behavior, so that we start building communities of consciousness. ~ David Martin, Ph.D.

Spend time with friends and family and share information. Start building a sense of community again, in whatever way makes sense to you. When you make a purchasing decision, analyze whether you’re supporting the evil being perpetrated, or choking its money supply. We need to start building micro-economies that can later grow into alternative economies. We need to start building support structures for when the financial and health care systems break.

“The fact is we are in a very unique moment in human history, and it probably is as close to the story of Joseph in Egypt as you can get. You know the seven fat years and then the seven skinny years? Well, guess what? We have a couple of fat years left. You know what we should be doing?

We should be investing in our networks of relationship. We should be investing in our networks of community. We should be building those resilient fibers that hold us together because we know that there is a famine coming. And we are in a unique position right now to actually do something about it.

So, start with yourself. Make sure that what you put into your body is aligned to your health. Make sure that what you do with your body is aligned to your health. And then as you do that, invite other people into living a life that in fact models that behavior, so that we start building communities of consciousness. And as we build those communities, we will start building currencies of consciousness ...

There are a bunch of ways that we can solve these problems, and we can do it using the market. We can do it using our consciousness, but we need our consciousness, we need our community, and we need our currency to be organically aligned to humanity again.”

How to Break the Propaganda Cycle

Doing the things mentioned above will also further another task at hand, which is to break the propaganda cycle. The key, really, is to simply live your life as healthily and joyously as possible, so that people around you can see there are others out there who aren’t living in fear. Eventually, they’ll start seeing they actually have a choice.

“Listen, propaganda cannot stand against the truth of a life well lived,” Martin says. “It can never stand against that truth. What we're trying to do is the wrong energy. We're trying to confront irrationality with rationality. But what we need to be doing is being persistent in showing up and living in a way that people look at it and say, ‘I'll have what she's having.’

This is your ‘Harry Met Sally’ moment. This is that restaurant scene. This is your moment to be a person who outlasts the half-life of the propaganda reflex. And I've seen way too many people try to engage energetically in the debate where they enter into conflict and it destroys their well-being.

Don't be the miserable angry one. Be the one at the table who is the one worth looking at and going, ‘I'll have what he's having. I'll have what she's having.’ Live a life that is desirable, and you'll see propaganda become emasculated instantaneously …

All the time while Gov. [Ralph] Northam here in Virginia was telling us that we could not have gatherings, we continued our workshops. We had our table full of 15, 20, 25 people, and our official policy was that if you signed up for our workshop, for the time you were in our home we adopted you as family, because the legal exemption in Virginia was that family didn't count.

So, we adopted everybody for the week. We had every kind of cousin, uncle, aunt, brother, sister, child, granny. It was all family. We went through the entire shutdown having a table full of fellowship. And you know what? Everybody in the neighborhood said, ‘I'd love to have what they're having.’"

[blogwiseguy123world]

Global DNA Vaccine Market Research Report 2018-2023

Summary – A new market study, titled "Global DNA Vaccine Market Research and Forecast, 2018-2023 has been featured on WiseGuyReports.

DNA vaccines Market are the third generation vaccines that designed to overcome the undesirable properties of conventional vaccines. The increasing exposure of population to infectious diseases and increasing number of antibiotics resistant pathogens have created the need for effective and low-cost vaccination, which would provide long lasting immunity. DNA vaccines have low risk of infection, easy transportation and stability at room temperature and hence are advantageous over traditional vaccines. DNA vaccines target a wide range of traditional pharmaceutical markets, such as cancers and allergies, as well as infectious diseases.

Also read – https://www.medgadget.com/2019/05/dna-vaccine-market-2019-by-manufacturers-regions-type-and-application-forecast-to-2023.html

The global DNA vaccines market is experiencing rapid growth owing to the factors such adoption of DNA vaccines in healthcare, low costs of DNA vaccines, and increasing investments in DNA technology. The increase in the prevalence of chronic diseases such as cancer, hepatitis, HIV and others are augmenting the growth of the global DNA vaccine market. Moreover, relative ease of large-scale manufacturing compared to traditional approach and less storage requirement are some of the key market drivers. The other factors augmenting the growth of the market includes increasing clinical trials for DNA vaccines both animal based and human based. Several DNA vaccine clinical trials have been recently completed or are currently ongoing, such as ZYC101 (Eisai Pharmaceuticals) has completed phase I trial. HPV-16 and HPV-18 E6/E7 are being evaluated in a phase I clinical trial (Inovio Pharmaceuticals). DNA vaccines have already made significant progress to date. Nearly 100 clinical trials are on-going in humans for a wide range of diseases, and there is a deep pipeline of preclinical projects.

However, uncertainty in regulatory policies and less penetration of DNA vaccine technology in the emerging economies is hindering the growth of the market. However, the increasing benefits offered by the DNA based vaccines and increasing awareness will have a positive impact on the growth of the market in the future.

The DNA vaccine market is segmented on the basis type, technology and application. On the basis of type, the market is segmented into animal DNA vaccine and human DNA vaccine. On the basis of technology, the market is bifurcated into Plasmid DNA vaccine and plasmid DNA delivery technology. On the basis of application, the market is divided into oncology, infectious diseases and others. The market for oncology based DNA vaccines and Infectious diseases is one of the largest segment for the DNA based vaccines. Clinical trials for DNA vaccines to treat cancer including metastatic melanoma, prostate, and pancreatic cancer, and other solid tumors, are showing promising results. Inovio Pharmaceuticals has also been working on a DNA-based vaccine for Zika since December 2015.

The global DNA vaccine market is analysed on the basis of the geographical regions that are contributing significantly towards the growth of the market. North America dominates the global DNA vaccine market due to the presence of all the major key pharmaceutical companies and increasing clinical trials. Europe is the second largest market followed by Asia pacific region. Asia pacific is the fastest growing segment due to increasing awareness about the benefits and flexibility offered by DNA vaccines.

The companies contributing to the growth of global DNA vaccine market are Astellas Pharma, Bharat Biotech, Dendreon Corporation, Indian Immunologicals Limited, GE Healthcare Life Sciences, GlaxoSmithKline Inc., Green Cross Corporation, Innovio Biomedical Corporation, Pfizer Pharmaceuticals, Sanofi, The Serum Institute of India Pvt. Limited, Zoetis Inc. and so on. US – AgriLabs in November 2017, announced the United States Department of Agriculture (USDA) approval of the first DNA vaccine licensed for chickens. The approval also represents the first for AgriLabs ExactVacTM DNA technology with ENABL adjuvant, the first DNA vaccine approved for influenza for veterinary use, and among the first DNA vaccines approved in the US for food animals.

• Global DNA vaccines market by type

• Global DNA vaccines market by technology

• Global DNA vaccines market by application

Research Methodology

The market study of DNA vaccine market is incorporated by extensive primary and secondary research conducted by research team at OMR. Secondary research has been conducted to refine the available data to breakdown the market in various segments, derive total market size, market forecast and growth rate. Different approaches have been worked on to derive the market value and market growth rate. Our team collects facts and data related to the market from different geography to provide a better regional outlook. In the report country level analysis is provided by analyzing various regional players, regional tax laws and policies, consumer behavior and macro-economic factors. Numbers extracted from Secondary research have been authenticated by conducting proper primary research. It includes tracking down key people from the industry and interviewing them to validate the data. This enables our analyst to derive the closest possible figures without any major deviations in the actual number. Our analysts try to contact as many executives, managers, key opinion leaders and industry experts. Primary research brings the authenticity in our reports.

Secondary sources include:

• Financial reports of companies involved in the market

• Authentic Public Databases

• Whitepapers, research-papers and news blogs

• Company websites and their product catalogue.

• Supplier Websites such as Alibaba, amazon for pricing analysis.

The report provides in-depth analysis on pricing, market size, intended quality of the product preferred by consumers, initial norms and vehicle segment. The report will serve as a source for 360-degree analysis of the market thoroughly integrating different models such as PEST analysis, Porter five analysis delivering insights into the market for better business decisions.

THE REPORT COVERS:

• Comprehensive research methodology of Global DNA Vaccine Market.

• This report also includes detailed and extensive market overview with Analyst insights & key market trends.

• Exhaustive analysis of macro and micro factors influencing the market guided by key recommendations.

• Analysis of regional regulations and other government policies impacting the Global DNA Vaccine Market.

• Insights about market determinants which are stimulating the Global DNA Vaccine Market.

• Detailed and extensive market segments with regional distribution of forecasted revenues.

• Extensive profiles and recent developments of market players.

For more details - https://www.wiseguyreports.com/reports/3186874-global-dna-vaccine-market-research-and-forecast-2018-2023

About Us:

Wise Guy Reports is part of the Wise Guy Research Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe.              

Contact Us:

NORAH TRENT                                                      

sales@wiseguyreports.com      

Ph: +162-825-80070 (US)                        

Ph: +44 2035002763 (UK)      

[corneliusmcvandy]

Tumblr 6

--This week, I responded using prompt c: “Develop a critique of the reading” --

Warwick Anderson’s “Excremental Colonialism” provides a strong example of the paradox between American colonial actions and the intentions and results of those actions. In the early 1900’s in the Philippines, Americans, disgusted by and worried about the public health implications of Filipino defecatory practices, undertook a nationwide effort to clean up waste practices. This undertaking closely resembled other American colonial actions like the promotion of Christian religion or western education. All were similar in that American control of the supposed action transcended as American control of more general ways of life. Anderson writes: “American bodily control legitimated and symbolized social and political control” (643), and indeed it did. However, the word “bodily” can be replaced with “religious,” “social,” or any number of alternatives and the sentence holds just as true: Anderson was in fact describing not just a particular phenomenon but the guiding, principled pattern of American colonialism. 

There is, however, one key difference. Undoubtedly, American intervention in Filipino sanitary affairs covered up a larger racial and social control effort. However, unlike an effort to colonize with religion or education, in which systems have enduring differences but one is not necessarily “better” than another, Americans in this case seem to be promoting an unarguably healthier society. After all, most modern societies, whether colonized or not, have adopted the sanitary standards pushed for by American colonizers, even while many have not adopted an American education system or other aspects of our culture. Therefore, while the negative implications of the American sanitation effort in the Philippines detailed by Anderson are true, and the racial undertones evident in his ethnography are despicable, the actual outcome of the sanitation effort deserves more attention than it is given by Anderson in his paper. 

Normally, colonization produces an “American” system, and whether or not that system is actually better is debatable (and usually depends on if the person judging it is American themselves). In this case, however, colonization produced a modern system of sanitation, but one that isn’t necessarily American. Anderson tries to make it American, calling toilets an American societal norm that “modern industry demanded” (650). And, while it’s true that the toilet industry benefits from sanitary norms, I could just as easily claim that vaccinations are a societal norm meant to funnel money into the pockets of pharmaceutical executives. Indeed they do, but the overall improved health and immunity of our society is well worth the trade off. Thus, while Anderson attempts to characterize sanitation as an American norm unfairly imposed on the people of the Philippines, the fact is that it’s a modern standard that would have eventually came to the country regardless of American involvement. 

With that said, there’s no doubt that the way in which Americans imposed this standard was done so at the detriment of the Filipino people and in a way that promoted American racial and social control. In fact, Americans probably shouldn’t have been in the country at all, at least not in such a capacity that they would be responsible for redefining social norms. The way Americans characterized Filipinos as dirty disease carriers and used this definition to create social distance and stigma was also no doubt imperial and racist, as was the overall imperial system that American’s instituted. I simply point out that Anderson overemphasizes “the American craze for building toilets” (661) as a socially constructed, economically motivated goal, where he could instead focus on the undoubtedly racist and imperial intentions and outcomes that mainly motivated this effort.

[jaeyloaded]

Nine Key Highlights Of Buhari’s Democracy Day Speech

President Muhammadu Buhari addressed Nigerians on 12 June the Democracy Day. It was his third national broadcast since his administration designated the day as a public day. He spoke on various achievements of his administration. P.M.News hereby gives nine key highlights of the achievements and plans:

Grow what you eat, eat what you grow President Buhari believes agriculture remains the key to Nigeria’s economic diversification strategy. And he is focused on making the sector the pillar of Nigeria’s economy. In his broadcast, he says that the Presidential Fertilizer Initiative programme will continue to deliver significant quantities of affordable and high-quality fertilizers to Nigerian farmers. Government is also revamping the cotton, textile and garment sector via a CBN Textile Revival Intervention Fund that would considerably reduce foreign exchange spent on cotton and other textile imports. Through the food security initiative, the Buhari administration is promoting “Grow What We Eat” and “Eat What We Grow”. Ajaokuta steel plant Buhari delivered one sentence on this embarrassing project waiting for completion since 1976. He said his government has directed the resuscitation of the Ajaokuta Steel Plant based on Government-to-Government financing and a Public-Private Sector financing. What he did not repeat was that the Russian government is working with the Africa Import and Export Bank, to pool funds in excess of $1.4bn to revive the steel plant designed and built by the Russian Steel Company, TyazhpromExport. Buhari brokered the new deal with his Russian counterpart, Vladimir Putin, during his visit to Russia in October 2019. Power sector Again just like steel, the Power Sector remains a mirage for Nigerians. Buhari says in the broadcast that his government is executing some critical projects through the Transmission Rehabilitation and Expansion Programme. Some of the projects under execution are the Alaoji to Onitsha, Delta Power Station to Benin and Kaduna to Kano; the 330kv DC 62km line between Birnin Kebbi and Kamba; the Lagos/Ogun Transmission Infrastructure Project; the Abuja Transmission Ring Scheme; and Northern Corridor Transmission Project. Then Buhari speaks on the Siemens angle: the agreement with the German conglomerate is that it will transmit and distribute a total of 11,000 Megawatts by 2023, to serve Nigeria’s electricity needs. Roads, Rail, water transport Buhari certainly wants to be remembered that his administration revamped and developed Nigeria’s infrastructure. He says his government is growing the stock and quality of Nigeria’s roads, rail, air and water transport infrastructure. “Through the SUKUK-Funded Road Projects, a total of 412km of the targeted 643km road projects have been completed, representing 64%. The Presidential Infrastructure Development Fund projects are also progressing very well. On the 2nd Niger Bridge, piling work has been completed and the approach roads are being constructed. 48% of work on this bridge has been achieved. “We have constructed 102km of the 376km Abuja – Kaduna – Kano Road, representing 38%, and the 42.9km Obajana – Kabba Road is 87.03% complete. “We are extending and upgrading our railway network too. We are introducing more locomotives, coaches and wagons for the Abuja-Kaduna Rail Line. “The Central Ajaokuta – Itakpe – Warri Line has been completed and is being extended from Itakpe to Abuja on one end and from Warri Town to Warri Port on the other. “The Lagos-Ibadan Rail Line is 90% completed and would be extended to the Lagos Port which would help address the long-standing grid-lock at the Apapa port. “The Kano – Maradi Single Track Standard Gauge Railway, Coastal Railway Project and Port Harcourt – Maiduguri Standard Gauge Railway, with its associated branch lines running through the South Eastern and Gombe States, industrial park and Bonny Deep Sea Port are all ready for concessioning. First Bidding for marginal oil fields Buhari, as Nigeria’s oil minister was thrilled to announce that for the first time in over ten years, Nigeria is conducting bidding process for 57 Marginal Oil Fields to increase revenue and increase the participation of Nigerian companies in oil and exploration and production business. “We continue to grow local content in other areas of the oil and gas sector with the disbursement of funds from the $200 million Nigerian Content Intervention Fund to indigenous manufacturers and service providers. Insurgency and Banditry President Buhari promised to enthrone security in Nigeria five years ago. But insurgency has not ended, what with the killing of 81 villagers in Gubio LG of Borno this week. Banditry, kidnapping, other forms of criminality are rising across the nation. Buhari says the security issues are being accorded appropriate priorities and the men and women of the Armed Forces of Nigeria have considerably downgraded such threats across all geo-political zones. He reiterated again that all the Local Governments that were taken over by the Boko Haram insurgents in Borno, Yobe and Adamawa have long been recovered and are now occupied by indigenes of these areas who were hitherto forced to seek a living in areas far from their ancestral homes. “The total collapse of the economies of these areas, which constituted a threat to our food security, has also been reversed with the gradual recovery of farming and other economic activities”, he says. He then apologised for the recent sporadic incidents with tragic loss of lives in Katsina and Borno States as a result of criminals taking advantage of COVID-19 restrictions. “Security Agencies will pursue the perpetrators and bring them to swift justice”, he promised.. COVID-19 and national response Expectedly Buhari devoted a considerable part of his address on the raging COVID-19 pandemic, a phenomenon that has disrupted the entire world this year. “Fellow Nigerians, the year 2020 has been like none other”, Buhari says. “In January 2020, the COVID-19 was declared a global pandemic by the World Health Organization. The number of global infections has risen from less than 80,000 shared between China and eighteen other countries to over 7 million spread over 216 countries and on all continents. “Nigeria recorded its first case of COVID-19 on February 27th 2020 and within the first 100 days, I have had cause to address the nation on three occasions within one month, which underscores the gravity of this pandemic. “There is no doubt that this pandemic has affected the global economy and all known socio-economic systems. It has also brought grief and pain to families that have lost their loved ones. Like many Nigerians, I feel the grief and pain not only as your President but also as someone who has lost a close member of my staff and some relatives and friends. “The impact of the pandemic has disrupted our economic system and to ensure its functioning while still addressing the spread, the Federal Government put in place a number of various non-pharmaceutical measures to slow down the spread of the virus, in addition to a progressive re-opening of the economy. “As part of the strategy to create jobs in reducing the effect of COVID-19 on our youths, I directed the employment of 774, 000 Nigerians. These youths will be engaged in Special Public Works Programme aimed at cushioning the effects of economic downturn. Each of the 774 local government areas in the country will be allotted 1,000 slots. I am pleased to report that this programme has commenced. “I am confident that the steps being taken by the PTF would result in flattening the COVID-19 curve. I, therefore, implore all Nigerians to abide by the approved guidelines and protocols. There is hope for us all if we take individual and collective responsibility. “Government is determined to turn this COVID-19 challenge into a motivation to action by building a nation-wide public health care system that will help us overcome the COVID-19 pandemic and prepare for any future outbreak. “Already, we have begun to look inward and I charge our inventors, researchers and scientists to come up with solutions to cure COVID-19”, he says. Anti-corruption moves Government has continued to implement accountability and transparent policies through the Open Government Partnership and the transparency portal on financial transactions. “Similarly, we have strengthened auditing and accountability mechanisms so as to ensure that rules and regulations are followed strictly. “Anti-Corruption Agencies have secured more than 1,400 convictions and also recovered funds in excess of N800 billion. These monies are being ploughed into development and infrastructure projects”. Cost of governance The Public Service of Nigeria remains the bedrock for the formulation and implementation of policies, programmes and projects in the country. This accounts for why it continues to evolve especially as new socio-economic challenges emerge for Government to address. In the face of dwindling resources and rising cost of governance, I have authorised that the White Paper on the Rationalisation of Government Parastatals and Agencies be reviewed for implementation. Read the full article

[biomedgrid]

Biomed Grid | Application of Optimal Control Theory to Biomedical and Biochemical Processes

Abstract

Optimal control theory is a highly developed subject. It has been applied in diverse fields of engineering, physics, economics, operation research, management sciences, policy planning etc. In particular, this subject has been successfully applied to bio-medical engineering problems like artificial heart, prosthesis. In this paper we present a brief summary of two recent papers on cancer immunotherapy and bio-reactors.

Introduction

In a recent paper [1] we proposed a dynamic model to represent the population of antigens and antibodies in cancer patients, in particular, the antigen-specific-antibody interactions to elicit immune response that leads to the death of cancer cells. The antibodies are known to be powerful medications for cancer immunotherapy. We published extensive numerical results in [2] demonstrating efficacy of the method. In another paper we considered bio-reactors and their optimal control and presented some interesting numerical results in [3].

Basic Principle of Immunotherapy

Mathematical modelling of bio-chemical processes has been widely used to study dynamic behavior of biological phenomena [4-6]. Results of such mathematical analysis can be used in both clinical and experimental settings. In the era of intense and rapid development of cancer immunotherapy, such efforts can prove to be significant in developing effective and efficient drug administration regimes and strategies. Currently, immunotherapy is the most promising and noninvasive cancer treatment approach compared to other well established therapies, such as chemotherapy. See the extensive references given in our paper [2]. The basic idea behind the immunotherapy is to use any feasible clinical technique that can enhance the patients immune system to destroy the antigens, for example, the cancer cells. This rapidly developing field of cancer immunology [4,5] has discovered new methods for treating cancer known as immunotherapy whereby the natural immune system of the human body is enhanced to fight cancer. The basic principles are briefly described as follows:

a. Checkpoint modulators: Here the idea is to block the ability of the so called checkpoint proteins from limiting the strength and duration of the natural immune response. There are several antibodies (IplimumAB, NivolumAB) which can act as immune checkpoint inhibitors.

b. Immune cell therapy: This immunotherapy is called ACT (Adoptive Cell Transfer). Here T-cells, infiltrating the tumor, called Tumor Infiltrating Lymphocytes (TILS), are col- lected from the patients tumor and cultured in the laboratory in large quantity and then activated by treatment with Cytokines and infused in the patients body which then attack and destroy the tumor cells.

c. Therapeutic Antibodies: Here antibodies are produced in the laboratory and linked to certain toxic substances (such as bacterial toxin). Such antibodies are called ADC (Antibody- Drug-Conjugates) and once they are administered to the patient, they bind on to cancer cells which absorb the toxic chemical leading to shrinkage and destruction of the tumor.

d. There are few other powerful techniques such as Cancer Treatment Vaccines and Immune System Modulators see [1].

Optimal Control of Immune System

In all the techniques as described above, antibodies are used to interact with antigens de- structively leading to annihilation of both and freeing the host body of toxin pathogens and cancer. We consider the dynamics of antibody-antigen interaction. In general, the dynamics of such systems is governed by a system of partial differential equations of reaction diffusion type. Let B stand for antibody and G for antigens. It is known that for each antigen there is a specific antibody that can bind on to and destroy it. So there are as many different antibodies as there are antigens. We assume that there are n different antigens and correspondingly n different antibodies. We denote their population densities by {Bi ,Gi ,i =1, 2,..., n} . The governing equations are given by the following system of partial differential equations defined on I × D where I = [0, T ] is the time domain and D ⊂ R3 denotes the spatial domain representing the patients tumor

These equations describe the temporal and spatial evolution of the antibodies and antigens. The parameters , {di ci} are the diffusion coefficients and Δ denotes the Laplacian in , R3,{αi} denote the production rates of antibodies by the natural immune system, βi, j is the interaction coefficient of the i-th antibody with the j-th antigen and γi,k is the production rate of antibodies induced by the control drug k u . If , γi,k =0 , the k-th drug has no contribution towards the production of antibody Bi. The parameters {δi} denote the intrinsic growth rates of antigens (for example cancer cells) and ηi, j denotes the interaction coefficient of the population of antibodies with the i-th antigen. The values of these interaction coefficients are generally negative. The objective is to promote the growth and strength of antibodies which can destroy the antigens. This is done by prescribing appropriate drugs (foods) for a period of time I [0, T] so as to eliminate the antigen population or bring it down to a harmless level. To achieve this goal one may choose the objective functional as

where {ωi>0} are the weights given to each of the species of antigen population and u denotes the control vector u = {uk,k = 1,2, . . . , m}.The control drugs are subject to certain clinical constraints such as the maximum admissible doses. This constraint is described by a compact set . The objective is to choose a control policy (a function of time) that minimizes the above functional. This problem can be solved by using the necessary conditions of optimality as given in [1, Theorem 4.1, p60]. This is computationally intensive. So for simplicity, in our recent paper [2], we used the finite dimensional version of the system of equations (1)-(2) by eliminating the diffusion coefficients {di ci} . This approximation is valid if, either the diffusion coefficients are significantly small, or the domain D is sufficiently small so that one can consider the population density to be uniform throughout the domain D.

The simplified model is given by

where now Bi, Gi are only functions of time. For the simplified (finite dimensional) model we used Pontryagin minimum principle to determine the optimal control prescribing the optimal doses as function of time. The numerical results are very encouraging and instructive. For details the reader is referred to [2].

Optimal Control of Bio-Reactors

There are many different bio-reactors. Some are designed for pharmaceutical industries to produce drugs. Another class of Bio-reactor is a system that can be used to degrade contaminants in ground water with microorganisms. It is used for waste water treatment. It is known that in a bioreactor the concentration of both bacteria and contaminants evolves in time and space. This can be described accurately only by a pair of partial differential equations of reaction diffusion type. However, we can consider the simplified model of a well- stirred bio-reactor where the population densities of bacteria and contaminants are spatially uniform but vary with time. The simplified system model is given by the following set of ordinary differential equations [3]:

where the parameters {α ,β ,γ }are all positive, for example, {α = 0.5,β = 0.2,γ = 5}. The state 1x (t) denotes the concentration of bacteria while x2 (t) represents the concentration of contaminants all at time t. The concentration of input nutrient denoted by u(t) serves as the control variable. It is well-known that the bacteria degrades contaminants via co-metabolism, meaning that the degradation of the contaminants is a byproduct of the bacterial metabolism. The objective is to reduce the concentration of contaminants by the end of a given time period I ≡ [0,T] . So it is natural to consider the cost functional as

where w denotes the weight given to the level of concentration of contaminants. The optimal control was determined by using the necessary conditions of optimality developed in our paper [3, Theorem 4.2, p6]. For detailed numerical results the reader is referred to [3].

Read More About this Article: https://biomedgrid.com/fulltext/volume3/application-of-optimal-control-theory-to-biomedical-and-biochemical-processes.000683.php

For more about: Journals on Biomedical Science :Biomed Grid

[sciencebulletin]

Researchers discover process to sustainably produce psilocybin, a drug candidate that could help treat depression

Andrew Jones at Miami University and his team of students may have developed a research first. Through metabolic engineering, they discovered a way to sustainably produce a promising drug candidate to help patients with treatment-resistant depression. Their findings are published in the journal Metabolic Engineering titled, "In vivo production of psilocybin in E. coli." Psilocybin is now in clinical trials, and medical professionals see promising results for its use in treating addiction, depression and post-traumatic stress disorder in humans. Jones, assistant professor in Miami's department of chemical, paper, and biomedical engineering, believed he could come up with a process using genetically engineered bacteria to produce the drug candidate. The chemical, psilocybin, is naturally found in a specific mushroom, Psilocybe cubensis. Jones said to mass produce psilocybin from its natural mushroom host, it would require extensive real estate and time. Currently, alternative synthetic chemical production methods are used but are very expensive. Jones, the principal investigator of this research, wanted a solution that maintains biological integrity and reduces production costs. Finding an optimal organic host Through metabolic engineering, which finds ways to increase a cell's ability to produce a compound of interest, his team of students developed a series of experiments to identify optimal psilocybin production conditions. The recently published article describes their work to optimize the production of psilocybin in the Escherichia coli bacteria. The team is using a well-known E. coli strain that is engineered for safe lab production. "We are taking the DNA from the mushroom that encodes its ability to make this product and putting it in E. coli," he said. "It's similar to the way you make beer, through a fermentation process. We are effectively taking the technology that allows for scale and speed of production and applying it to our psilocybin producing E. coli." Their end result is a significant step toward demonstrating the feasibility of producing this drug economically from a biological source. "What's exciting is the speed at which we were able to achieve our high production. Over the course of this study we improved production from only a few milligrams per liter to over a gram per liter, a near 500-fold increase," Jones said. He gives much credit and praise to his students who designed many of the experiments performed during the 18-month-long study. "A big part of my job is training undergraduates to do this work. The basic idea was mine, but much of the experimental design fell on the students. Early on, I would help guide them in the experimental design process. Toward the end, they were becoming more independent. That's the type of student we want as they near graduation," Jones said. Learning to run laboratory experiments Lead author Alexandra (Lexie) Adams, a junior chemical engineering major, became a member of the research team her freshman year, just as the Jones Lab was getting started. Patient and meticulous, Jones worked with the admittedly nervous Adams on the basics of laboratory research. It paid off. The initial work was done in the summer of 2018 as Adams and another undergraduate student co-author, Nicholas Kaplan, took part in Miami's Undergraduate Summer Scholars Program. The program provides funding to students for undergraduate research. Both students, working on separate studies, learned the ins and outs of research, gaining confidence and learning lessons as the summer progressed. Kaplan, a junior chemical engineering major, studied the feasibility of cyanobacteria as another potential metabolic engineering host. His findings showed mixed results, and it was decided that the lab team would focus on Adams' psilocybin in E. coli project. Celebrating a research breakthrough Adams remembers when they saw the breakthrough in their research. Their goal was to transfer the DNA from the mushroom and see activity in the E. coli host. "Once we transferred the DNA, we saw peak emerge in our data. We knew we had done something huge," she said. Other members of the team included: graduate Zhangyue "Tom' Wei (Miami '19), graduate John "Jack' Brinton (BS Miami '17, MS Miami '19), junior Chantal Monnier, senior Alexis Enacopol, and staff member Theresa Ramelot, instrumentation specialist. Both Adams and Kaplan continue to work with Jones. The students are leading projects that build on the recent success of the psilocybin work. Each of them is starting to pass down what they have learned in the lab by mentoring new undergraduate students that join the Jones Lab. "It's important for to understand the big picture so they see the reasons for the different steps of the experiments," Kaplan said. Jones is pursuing the next phase of this research by studying ways to make the E. coli bacteria a better host—the next step toward enabling sustainable production at levels required by the pharmaceutical industry. Provided by: Miami University More information: Alexandra M. Adams et al. In vivo production of psilocybin in E. coli. Metabolic Engineering (2019). DOI: 10.1016/j.ymben.2019.09.009 Image: Junior Alexandra (Lexie) Adams is the lead author in a published article of their findings in a scientific journal. Credit: Miami University Read the full article

[nickyshukla1]

Global DNA Vaccine Market Analysis, Trends and Opportunities 2018-2023

Summary - A new market study, titled “Global DNA Vaccine Market Analysis, Trends and Opportunities 2018-2023” has been featured on WiseGuyReports

DNA vaccines Market are the third generation vaccines that designed to overcome the undesirable properties of conventional vaccines. The increasing exposure of population to infectious diseases and increasing number of antibiotics resistant pathogens have created the need for effective and low-cost vaccination, which would provide long lasting immunity. DNA vaccines have low risk of infection, easy transportation and stability at room temperature and hence are advantageous over traditional vaccines. DNA vaccines target a wide range of traditional pharmaceutical markets, such as cancers and allergies, as well as infectious diseases.

The global DNA vaccines market is experiencing rapid growth owing to the factors such adoption of DNA vaccines in healthcare, low costs of DNA vaccines, and increasing investments in DNA technology. The increase in the prevalence of chronic diseases such as cancer, hepatitis, HIV and others are augmenting the growth of the global DNA vaccine market. Moreover, relative ease of large-scale manufacturing compared to traditional approach and less storage requirement are some of the key market drivers. The other factors augmenting the growth of the market includes increasing clinical trials for DNA vaccines both animal based and human based. Several DNA vaccine clinical trials have been recently completed or are currently ongoing, such as ZYC101 (Eisai Pharmaceuticals) has completed phase I trial. HPV-16 and HPV-18 E6/E7 are being evaluated in a phase I clinical trial (Inovio Pharmaceuticals). DNA vaccines have already made significant progress to date. Nearly 100 clinical trials are on-going in humans for a wide range of diseases, and there is a deep pipeline of preclinical projects.

 ALSO READ: https://www.medgadget.com/2019/05/dna-vaccine-market-2019-by-manufacturers-regions-type-and-application-forecast-to-2023.html

 However, uncertainty in regulatory policies and less penetration of DNA vaccine technology in the emerging economies is hindering the growth of the market. However, the increasing benefits offered by the DNA based vaccines and increasing awareness will have a positive impact on the growth of the market in the future.

The DNA vaccine market is segmented on the basis type, technology and application. On the basis of type, the market is segmented into animal DNA vaccine and human DNA vaccine. On the basis of technology, the market is bifurcated into Plasmid DNA vaccine and plasmid DNA delivery technology. On the basis of application, the market is divided into oncology, infectious diseases and others. The market for oncology based DNA vaccines and Infectious diseases is one of the largest segment for the DNA based vaccines. Clinical trials for DNA vaccines to treat cancer including metastatic melanoma, prostate, and pancreatic cancer, and other solid tumors, are showing promising results. Inovio Pharmaceuticals has also been working on a DNA-based vaccine for Zika since December 2015.

The global DNA vaccine market is analysed on the basis of the geographical regions that are contributing significantly towards the growth of the market. North America dominates the global DNA vaccine market due to the presence of all the major key pharmaceutical companies and increasing clinical trials. Europe is the second largest market followed by Asia pacific region. Asia pacific is the fastest growing segment due to increasing awareness about the benefits and flexibility offered by DNA vaccines. The companies contributing to the growth of global DNA vaccine market are Astellas Pharma, Bharat Biotech, Dendreon Corporation, Indian Immunologicals Limited, GE Healthcare Life Sciences, GlaxoSmithKline Inc., Green Cross Corporation, Innovio Biomedical Corporation, Pfizer Pharmaceuticals, Sanofi, The Serum Institute of India Pvt. Limited, Zoetis Inc. and so on. US – AgriLabs in November 2017, announced the United States Department of Agriculture (USDA) approval of the first DNA vaccine licensed for chickens. The approval also represents the first for AgriLabs ExactVacTM DNA technology with ENABL adjuvant, the first DNA vaccine approved for influenza for veterinary use, and among the first DNA vaccines approved in the US for food animals. • Global DNA vaccines market by type • Global DNA vaccines market by technology • Global DNA vaccines market by application

Research Methodology The market study of DNA vaccine market is incorporated by extensive primary and secondary research conducted by research team at OMR. Secondary research has been conducted to refine the available data to breakdown the market in various segments, derive total market size, market forecast and growth rate. Different approaches have been worked on to derive the market value and market growth rate. Our team collects facts and data related to the market from different geography to provide a better regional outlook. In the report country level analysis is provided by analyzing various regional players, regional tax laws and policies, consumer behavior and macro-economic factors. Numbers extracted from Secondary research have been authenticated by conducting proper primary research. It includes tracking down key people from the industry and interviewing them to validate the data. This enables our analyst to derive the closest possible figures without any major deviations in the actual number. Our analysts try to contact as many executives, managers, key opinion leaders and industry experts. Primary research brings the authenticity in our reports.

Secondary sources include: • Financial reports of companies involved in the market • Authentic Public Databases • Whitepapers, research-papers and news blogs • Company websites and their product catalogue. • Supplier Websites such as Alibaba, amazon for pricing analysis. The report provides in-depth analysis on pricing, market size, intended quality of the product preferred by consumers, initial norms and vehicle segment. The report will serve as a source for 360-degree analysis of the market thoroughly integrating different models such as PEST analysis, Porter five analysis delivering insights into the market for better business decisions. THE REPORT COVERS: • Comprehensive research methodology of Global DNA Vaccine Market. • This report also includes detailed and extensive market overview with Analyst insights & key market trends. • Exhaustive analysis of macro and micro factors influencing the market guided by key recommendations. • Analysis of regional regulations and other government policies impacting the Global DNA Vaccine Market. • Insights about market determinants which are stimulating the Global DNA Vaccine Market. • Detailed and extensive market segments with regional distribution of forecasted revenues. • Extensive profiles and recent developments of market players.

FOR MORE DETAILS: https://www.wiseguyreports.com/reports/3186874-global-dna-vaccine-market-research-and-forecast-2018-2023

 About Us:

Wise Guy Reports is part of the Wise Guy Research Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe.                

Contact Us:

NORAH TRENT                                                      

sales@wiseguyreports.com       

Ph: +162-825-80070 (US)                          

Ph: +44 203 500 2763 (UK)      

[golicit]

 Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud”

Whistleblowing has a long and respected tradition in the United States. In more recent times, whistleblowing and its protections have been part of several legislative schemes, including, for example, the creation in the Dodd-Frank Act of the SEC Whistleblower Program. The recent whistleblower complaint about President Trump’s July 2019 phone call with Turkish President Erdoğan underscores the continued important role of whistleblowing in the our political and business culture. As the events surrounding the recent whistleblowing complaint also show, whistleblowing is often regarded as a provocative act, and that, at a minimum, whistleblowing can be highly divisive.

  A recently published book, “Crisis of Conscience: Whistleblowing in the Age of Fraud,”  written by journalist Tom Mueller, takes a detailed look at the role of whistleblowing in our culture, and the ways in which, despite all of the surrounding controversy, whistleblowing remains an indispensable part of maintaining order and enforcing our values and expectations.

  Mueller begins his book with several examples of whistleblowing from earlier times, including a whistleblowing incident in which abuses were alleged against a U.S. military official in our country’s earliest days. After an interesting account of a whistleblower who raised allegations of payoffs and corruption involving a major pharmaceutical company, Mueller then reviews some higher profile examples of whistleblowing from the recent past, including the story of Ernest Fitzgerald, who in the late 60s and early 70s famously blew the whistle on egregious cost overruns in the Lockheed C-5 cargo plane program, and Daniel Ellsberg, who passed the Pentagon Papers — detailing the deeply-flawed U.S. involvement in Vietnam — to the New York Times and the Washington Post.

  The book also recounts a number of other whistleblower incidents with which I was less familiar, including in particular the truly disturbing account of the numerous whistleblowers that have come forward over the years to denounce dangerous waste and mismanagement at the Hanford Nuclear Reservation in the state of Washington.  The accounts relating to the problems are particularly alarming because of the clear suggestion that health and safety issues were routinely compromised.

  Another incident with which I was not familiar was the sordid story of the Harvard Project, a U.S.-government supported effort led by the Harvard Institute for International Development that was intended to lead post-Soviet Russia to a democratic government and a market-based economy but instead became known for conflicts of interest and  misuse of U.S. government funds.

  While many of the whistleblower incidents Mueller describes involve governmental misconduct, finance, he suggests, is whistleblowing’s “new frontier.” He recounts numerous incidents of (frequently disregarded at the time) whistleblowing in the lead-up to the global financial crisis. By the same token, whistleblower revelations “have been central” to many of the regulatory enforcement actions brought against the financial services industry in the last decade, in the U.S. and elsewhere. Various financial frauds arose only because of whistleblower reports, including foreign exchange and commodities fraud, money laundering, and violation of banking integrity and tax laws. Among the disturbing feature of this account is the disturbing frequency with which certain names recur: Citigroup, JP Morgan, Barclays, UBS, and the Royal Bank of Scotland, among others. As Mueller reports, “wrongdoing at the big banks is massive and repeated.”

  With these and many other more recent examples, Mueller shows a recurrent pattern, where highly-principled individuals, motivated by outrage at or even horror of misconduct they have witnessed, are motivated to become a whistleblower, in order to try to draw attention to and to end perceived misconduct. In the recurrent pattern, this first step is followed by several almost inevitable steps, including a massive campaign by the accused individuals and organizations to try to identify, silence, undercut and retaliate against the whistleblower (rather than addressing the underlying misconduct alleged), and, then, next, an almost always years-long period where the whistleblower is subject to ostracism, social isolation, loss of employment, and financial ruin. In some cases, the whistleblower ultimately achieves some form of vindication, although one disturbing feature of many of these incidents is the frequency with which the wrongdoers not only retain their positions but even prosper despite the extent of the misconduct revealed.

  Mueller’s book is at its strongest when he recounts the recurring efforts of those subject to a whistleblower report to try to contain, neutralize, and discredit whistleblowers. There is a very good reason why statutory whistleblower programs usually incorporate strict anti-retaliation provisions.

  The story of what happened after the Pentagon Papers’ release is particularly interesting in that regard. Once then-President Nixon learned about the documents’ release, he authorized and launched a massive and no-holds barred effort, first, to identify who released the documents, and then to retaliate, by attempting to discredit Ellsberg. I had forgotten that among other things Nixon did was that he authorized a break-in of Ellsberg’s psychiatrist’s office, in order to try to obtain dirt or compromising information in order to discredit Ellsberg. The break-in was one of the things that ultimately resulted in the dismissal of the criminal charges against Ellsberg. I thought about these things in recent days as I heard news reports that our current President has organized a team to identify the Erdoğan phone call whistleblower – and even before the whistleblower has been identified to try to discredit him or her, by suggesting that whistleblowers are spies that should be executed.

  The rise of whistleblowers over the last five decades is, Mueller suggests, the result of several inter-related factors: the rise and normalization of fraud; the growing interpenetration of corporations and the government; and the spread of secrecy. For example, Mueller returns again and again to the problems created by the revolving door between government regulators and industry. Insiders who can earn significant credibility by serving in a high-profile government role can hope to cash in by then working in the industry they were previously regulating. These individuals have a significant financial incentive not to make waves, but instead to keep relationships smooth.

  The only way the casual corruption of these cozy relationships can be exposed and addressed is the action of a whistleblower that is willing to risk the security of their own position by calling out the excesses. There is a reason why the reaction to whistleblower is usually so strong and defensive; the whistleblower threatens the tacit assumptions underlying and mutual benefits that are available to those that support the status quo. There is a reason why whistleblowers often are outsiders; “Outsiders alone retain the freedom of spirit to recognize, and sometimes to renounce, corruption concealed beneath the mantle of authority, status, wealth. “

  I recommend Mueller’s book. It is very detailed, ambitious, and interesting.  His accounts of the crises of conscience that caused the whistleblowers to act, and of the consequences they then face, are both fascinating and inspiring.

  However, the book is not without its flaws. Mueller is at his best when he is describing specific whistleblower incidents, detailing the misconduct the whistleblowers witnessed and the agonizing process the whistleblowers go through before deciding to blow the whistle. These parts of the book are very compelling. Unfortunately, periodically, the book gets sidetracked by excursions into psychology, sociology, and behavioral economics; these sections are less compelling.

  Also, one of the Mueller’s missions in the book is to show that the rise of whistleblowing has become necessary because of what he perceives as the rise of fraud. (The subtitle of his book is “Whistleblowing in the Age of Fraud.”) One of the bogeymen that Mueller frequently invokes in trying to make this case is the Chicago School of Economics and the pervasiveness of market-based models in economics and politics. Whatever else one might make of Mueller’s attack on a school of economic thought, it represents a diversion from his stated mission of detailing the importance of whistleblowing. His recurring critique on the Chicago school represents one of several ways in which the book occasionally sets aside its journalistic approach and takes a polemic tone.

  The book is also really long. It is long because in many places it is unnecessarily over-written. For example, the book’s chapter about the problems at the Hanford nuclear facility, overall a particularly interesting chapter in the book, begins with a long description of the area surrounding the facility that starts like this: “Mergansers and pelicans feed in the shallows on stonefly larva and freshwater clams. A great blue heron stalks the waterline, pauses, spears a glistening fish with its javelin beak. A mule deer, grazing among the mulberry trees and cottonwoods by the riverbank, raises it head to watch us slip by.” On and on and on like that, for several paragraphs. There are unfortunately too many wordy detours in the book like this.  The book could have been at least a third shorter, without any loss. Indeed, it would be a better book if it were a third shorter.

  All of that said, the book is very interesting, and in the end, Mueller does present a persuasive case for the importance of whistleblowers in our society. His accounts of the courageous individuals who have dared to step forward and call out misconduct make for interesting reading. He also establishes the importance for all of us of encouraging whistleblowers to come forward and protecting them when they do. These seem like particularly important points to remember just now.

  Whistleblowers, Mueller writes,” take the responsibility for seeing with their own eyes and following their individual conscience, cutting through cant and rationalization to comprehend things as they really are.” They also “prove the power of the righteous voice.” They may even “lend us the courage we will need to reclaim entire realms of civic life.”

The post  Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud” appeared first on The D&O Diary.

 Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud” published first on

[lawfultruth]

 Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud”

Whistleblowing has a long and respected tradition in the United States. In more recent times, whistleblowing and its protections have been part of several legislative schemes, including, for example, the creation in the Dodd-Frank Act of the SEC Whistleblower Program. The recent whistleblower complaint about President Trump’s July 2019 phone call with Turkish President Erdoğan underscores the continued important role of whistleblowing in the our political and business culture. As the events surrounding the recent whistleblowing complaint also show, whistleblowing is often regarded as a provocative act, and that, at a minimum, whistleblowing can be highly divisive.

  A recently published book, “Crisis of Conscience: Whistleblowing in the Age of Fraud,”  written by journalist Tom Mueller, takes a detailed look at the role of whistleblowing in our culture, and the ways in which, despite all of the surrounding controversy, whistleblowing remains an indispensable part of maintaining order and enforcing our values and expectations.

  Mueller begins his book with several examples of whistleblowing from earlier times, including a whistleblowing incident in which abuses were alleged against a U.S. military official in our country’s earliest days. After an interesting account of a whistleblower who raised allegations of payoffs and corruption involving a major pharmaceutical company, Mueller then reviews some higher profile examples of whistleblowing from the recent past, including the story of Ernest Fitzgerald, who in the late 60s and early 70s famously blew the whistle on egregious cost overruns in the Lockheed C-5 cargo plane program, and Daniel Ellsberg, who passed the Pentagon Papers — detailing the deeply-flawed U.S. involvement in Vietnam — to the New York Times and the Washington Post.

  The book also recounts a number of other whistleblower incidents with which I was less familiar, including in particular the truly disturbing account of the numerous whistleblowers that have come forward over the years to denounce dangerous waste and mismanagement at the Hanford Nuclear Reservation in the state of Washington.  The accounts relating to the problems are particularly alarming because of the clear suggestion that health and safety issues were routinely compromised.

  Another incident with which I was not familiar was the sordid story of the Harvard Project, a U.S.-government supported effort led by the Harvard Institute for International Development that was intended to lead post-Soviet Russia to a democratic government and a market-based economy but instead became known for conflicts of interest and  misuse of U.S. government funds.

  While many of the whistleblower incidents Mueller describes involve governmental misconduct, finance, he suggests, is whistleblowing’s “new frontier.” He recounts numerous incidents of (frequently disregarded at the time) whistleblowing in the lead-up to the global financial crisis. By the same token, whistleblower revelations “have been central” to many of the regulatory enforcement actions brought against the financial services industry in the last decade, in the U.S. and elsewhere. Various financial frauds arose only because of whistleblower reports, including foreign exchange and commodities fraud, money laundering, and violation of banking integrity and tax laws. Among the disturbing feature of this account is the disturbing frequency with which certain names recur: Citigroup, JP Morgan, Barclays, UBS, and the Royal Bank of Scotland, among others. As Mueller reports, “wrongdoing at the big banks is massive and repeated.”

  With these and many other more recent examples, Mueller shows a recurrent pattern, where highly-principled individuals, motivated by outrage at or even horror of misconduct they have witnessed, are motivated to become a whistleblower, in order to try to draw attention to and to end perceived misconduct. In the recurrent pattern, this first step is followed by several almost inevitable steps, including a massive campaign by the accused individuals and organizations to try to identify, silence, undercut and retaliate against the whistleblower (rather than addressing the underlying misconduct alleged), and, then, next, an almost always years-long period where the whistleblower is subject to ostracism, social isolation, loss of employment, and financial ruin. In some cases, the whistleblower ultimately achieves some form of vindication, although one disturbing feature of many of these incidents is the frequency with which the wrongdoers not only retain their positions but even prosper despite the extent of the misconduct revealed.

  Mueller’s book is at its strongest when he recounts the recurring efforts of those subject to a whistleblower report to try to contain, neutralize, and discredit whistleblowers. There is a very good reason why statutory whistleblower programs usually incorporate strict anti-retaliation provisions.

  The story of what happened after the Pentagon Papers’ release is particularly interesting in that regard. Once then-President Nixon learned about the documents’ release, he authorized and launched a massive and no-holds barred effort, first, to identify who released the documents, and then to retaliate, by attempting to discredit Ellsberg. I had forgotten that among other things Nixon did was that he authorized a break-in of Ellsberg’s psychiatrist’s office, in order to try to obtain dirt or compromising information in order to discredit Ellsberg. The break-in was one of the things that ultimately resulted in the dismissal of the criminal charges against Ellsberg. I thought about these things in recent days as I heard news reports that our current President has organized a team to identify the Erdoğan phone call whistleblower – and even before the whistleblower has been identified to try to discredit him or her, by suggesting that whistleblowers are spies that should be executed.

  The rise of whistleblowers over the last five decades is, Mueller suggests, the result of several inter-related factors: the rise and normalization of fraud; the growing interpenetration of corporations and the government; and the spread of secrecy. For example, Mueller returns again and again to the problems created by the revolving door between government regulators and industry. Insiders who can earn significant credibility by serving in a high-profile government role can hope to cash in by then working in the industry they were previously regulating. These individuals have a significant financial incentive not to make waves, but instead to keep relationships smooth.

  The only way the casual corruption of these cozy relationships can be exposed and addressed is the action of a whistleblower that is willing to risk the security of their own position by calling out the excesses. There is a reason why the reaction to whistleblower is usually so strong and defensive; the whistleblower threatens the tacit assumptions underlying and mutual benefits that are available to those that support the status quo. There is a reason why whistleblowers often are outsiders; “Outsiders alone retain the freedom of spirit to recognize, and sometimes to renounce, corruption concealed beneath the mantle of authority, status, wealth. “

  I recommend Mueller’s book. It is very detailed, ambitious, and interesting.  His accounts of the crises of conscience that caused the whistleblowers to act, and of the consequences they then face, are both fascinating and inspiring.

  However, the book is not without its flaws. Mueller is at his best when he is describing specific whistleblower incidents, detailing the misconduct the whistleblowers witnessed and the agonizing process the whistleblowers go through before deciding to blow the whistle. These parts of the book are very compelling. Unfortunately, periodically, the book gets sidetracked by excursions into psychology, sociology, and behavioral economics; these sections are less compelling.

  Also, one of the Mueller’s missions in the book is to show that the rise of whistleblowing has become necessary because of what he perceives as the rise of fraud. (The subtitle of his book is “Whistleblowing in the Age of Fraud.”) One of the bogeymen that Mueller frequently invokes in trying to make this case is the Chicago School of Economics and the pervasiveness of market-based models in economics and politics. Whatever else one might make of Mueller’s attack on a school of economic thought, it represents a diversion from his stated mission of detailing the importance of whistleblowing. His recurring critique on the Chicago school represents one of several ways in which the book occasionally sets aside its journalistic approach and takes a polemic tone.

  The book is also really long. It is long because in many places it is unnecessarily over-written. For example, the book’s chapter about the problems at the Hanford nuclear facility, overall a particularly interesting chapter in the book, begins with a long description of the area surrounding the facility that starts like this: “Mergansers and pelicans feed in the shallows on stonefly larva and freshwater clams. A great blue heron stalks the waterline, pauses, spears a glistening fish with its javelin beak. A mule deer, grazing among the mulberry trees and cottonwoods by the riverbank, raises it head to watch us slip by.” On and on and on like that, for several paragraphs. There are unfortunately too many wordy detours in the book like this.  The book could have been at least a third shorter, without any loss. Indeed, it would be a better book if it were a third shorter.

  All of that said, the book is very interesting, and in the end, Mueller does present a persuasive case for the importance of whistleblowers in our society. His accounts of the courageous individuals who have dared to step forward and call out misconduct make for interesting reading. He also establishes the importance for all of us of encouraging whistleblowers to come forward and protecting them when they do. These seem like particularly important points to remember just now.

  Whistleblowers, Mueller writes,” take the responsibility for seeing with their own eyes and following their individual conscience, cutting through cant and rationalization to comprehend things as they really are.” They also “prove the power of the righteous voice.” They may even “lend us the courage we will need to reclaim entire realms of civic life.”

The post  Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud” appeared first on The D&O Diary.

 Book Review: “Crisis of Conscience: Whistleblowing in the Age of Fraud” syndicated from https://ronenkurzfeldweb.wordpress.com/

[vapesdirectory]

3 Controllers Reveal Tactics, and, Yes, How They Make Time, to Keep Learning

In about four months, the accounting and finance conference circuit will start to heat up, as professionals from companies of all shapes and sizes will descend upon hotels and convention centers in cities across the United States to peruse vendor exhibits, hobnob with their friends and peers at networking events, and attend workshops and seminars.  As an accounting journalist with zero accounting background, I would go to as many conference sessions as time would allow in order to educate myself about the latest accounting standards, tax law changes, and technology trends. And lo and behold, corporate controllers, who have extensive accounting and finance backgrounds, also attend these talks as a way to keep current on topics that directly relate to their position.  “I choose the seminars most applicable or valuable to me—usually a topic I am unfamiliar with, need additional experience, or when there are some changes coming, such as tax regulations,” said Karen Bacon, controller at Arcimoto , a Eugene, Ore.-based electric vehicle company.  And it’s not just accounting and finance matters that draw her attention. Bacon has attended conferences and sessions over the past few years that have focused on legal and credit law, human resources, IT, leadership, and technology.  “I always come away from conferences with new concepts and knowledge that I will be able to immediately communicate to my team or implement,” she said.  Bryan Woodhouse, vice president/corporate controller at New Castle Hotels & Resorts , a hotel/owner management company based in Shelton, Conn., said conferences and hospitality industry events help inform him of issues that may impact his group and his organization.  “The hospitality industry tends to be very collaborative, and as a result, my peers at other companies are a tremendous resource for information,” he said. “For example, discussions about current labor management applications and the platforms that integrate the various systems that other disciplines are using are key to managing the crucial data. Sharing what has worked, or not worked, for others is very helpful to me and my colleagues.”  Other learning strategies that work  Attending conferences is only one way for controllers to stay current or educated about accounting- and finance-related trends. Here are some others:  1. Social media. No, not Facebook. According to the three controllers I spoke to for this article, LinkedIn was the medium of choice.  “Combing through the posts on my LinkedIn network allows me to learn what is on people’s minds from varying industries, job functions, and regions,” said Timothy Sangiovanni, CPA, vice president/corporate controller at KemPharm Inc. , a Coralville, Iowa-based specialty pharmaceutical company. “In addition, LinkedIn provides the opportunity to reach out to an individual for a one-on-one discussion to bounce ideas off of or dig deeper into a specific matter.”  2. Networking events. Bacon often attends local networking events and uses social media to connect with other professionals in her area.  “The networking events range between HR- and IT-related issues to accounting and finance,” she said. “While I also network with other professionals who are not in my area, there is additional value in networking with other local professionals because they will better understand the dynamic of our local demographic.”  3. Webcasts and in-person trainings. Sangiovanni said he participates in one to two webcasts a month on average and one to two in-person trainings a year put on by professional organizations, professional services firms, and vendors.  “Webcasts allow me to stay up-to-date on current accounting and finance topics from my desk. However, the delivery method can lend itself to distraction by other activities in the office,” he said. “The in-person trainings offer the opportunity to learn about accounting and finance topics while networking with other accounting and finance professionals. They are more substantive, even while inconvenient from a travel and time perspective, as they allow for undivided attention to the information being presented.”  4. Reading online/print publications and books. As a member of the AICPA, Sangiovanni said he often reads the organization’s monthly magazine, Journal of Accountancy .  “Print magazines not only provide a vast amount of information in one place, but also the ability to save the magazine for later reference,” he said.  But when Sangiovanni wants to “take a step back from the granular accounting and finance perspective,” he’ll read books or other publications on management techniques, economics, and other business topics.  “Reading allows me to view our business and industry from a unique, high-level perspective,” he said. “Further, these books and other publications assist with identifying how my team and I fit into the overall organization and help mold my management style, as well as assist me in becoming a better leader.”  Woodhouse said he makes it a point to “take advantage of the resources that are at my fingertips, especially trade journals and professional sites like Going Concern.” If he needs more detail on a particular subject, Woodhouse said he’ll read a white paper on that topic or attend a webinar.  5. Teaching. Bacon is an adjunct instructor at a local university and teaches business and accounting courses. She also has taught several technology/software courses at the last two organizations where she worked.  “I find teaching valuable in many ways,” Bacon said. “For one, I am using textbooks in my courses with current information, material, and case studies. I also find teaching to be valuable in my development as a leader. I am helping develop and grow the minds of my students. This will directly impact my ability as a department manager.”  “Learning is an ongoing process”  The world of the corporate controller can be dizzying, as he or she oversees the monthly and year-end closes, produces financial reports, sets strategy, executes budgets and forecasts—and that’s just scratching the surface. So, where do controllers find the time to stay current and educated?  “I probably spend an average of 10 to 15 hours a week on my own development and education. There will be some weeks where I spend more time—especially when I am attending a conference—and other weeks where the time is much less,” Bacon said. “When I am teaching, I spend 15 to 20 hours a week on the course. Not all this time would count toward my own development, but I believe I learn as much from teaching as the students should be learning from the course.”  She added that the local networking events she attends are usually scheduled at lunchtime or after work, and the courses she teaches are either held in the evening or online.  Woodhouse said he doesn’t set aside a particular time of his day for enrichment; it just happens organically.  “Learning is an ongoing process for me,” he said. “Whether I’m catching up with colleagues, reading a trade journal, checking email, or reading the Wall Street Journal , it’s an engrained part of every day.”  Image: iStock/eternalcreative  The post 3 Controllers Reveal Tactics, and, Yes, How They Make Time, to Keep Learning appeared first on Going Concern .

[marceladeville0-blog]

Sales And also Advertising Task Summary Sample.

Many training programs in Human Resources management review the subject matter of marketing in the friendliness sector. This enables them to touch often five to 6 opportunities as numerous customers as your salespeople carry out. Researches have actually been performed revealing that those business which enhanced and preserved marketing during the course of an economic slump appreciated an explosion of all-natural development properly beyond those which reduced expenses. The cost every achievement of direct-mail advertising could be substantially under other advertising techniques. Your advertising and marketing will feel like a broken play plaything - pointless as well as no fun to have fun with. This is crucial that you produce a thorough, well-thought from service strategy. A number of the offline Avon advertising and marketing methods are actually getting in touch with every one of your friends as well as establishing Avon events, sending by mail out fliers, create a hot marker list, get references, ect. Your advertising information must be established baseding on the age group of the target market you are offering. . Where very most various other divisions are going to address these markets in a similar way, advertising and marketing team must address them all in different manner. Our several on-line sources feature our Worldwide Jobs Panel, video library as well as career webinar series. Advertising and marketing as all of us know is methods built by firms, services to predict and entice individuals to buy their items. Medical care Advertising and marketing against Powerful Competitors Watch Your backdoor and also hold on to your effective marketers. That was refreshing to unlearn out-of-date principles and learn new ideas in advertising and also company. Satisfy examine the module web content for suitability if you have significant anticipation or even expertise of advertising. A dedication oral plaque buildup naming all of them Top Online marketer for the Year or The majority of Appealing New Advertising Talent. This is also pertained to as Marketing Communications as well as features direct marketing, business occasions, brochures, web-sites, advertising and marketing. Below is a checklist from various advertising things as well as the stable of expenses associated with each. This certain part of writing will be telling our team several of the advertising and marketing ideas and approaches in order to start our own company from a moving provider! The digital advertising and marketing program consists of essential understanding of marketing and advertising ideas and vital know-how from statistical as well as rational tools. The focal point of the marketing concept is actually to identify as well as please the necessities of the customers. Certainly today, when the subject matter from marketing communications is raised, that is actually often brought up in the context from Internet marketing. And nothing else than the SMS advertising and marketing approach is the very best to do this at the blink of an eye and that too at an incredibly inexpensive. He still utilizes it and the final opportunity I spoke to him (regarding a full week ago) he was actually around five thousand hits per day. Each of these marketing regions can be checked out as a small planning - along with action-oriented steps as well as activities for you to observe. When prepping your B2B advertising and marketing techniques for launch, begin along with a texting paper that determines the primary concepts and also value-based statements that will definitely connect every one of your tasks together for max effectiveness. This functions since unlike emails and also tv commercials people. just do certainly not shut off their phone when they obtain a text message in. Thus using this info in palm all you have actually entrusted to do in order to get your business on the leading edge of marketing is actually find the ideal company to get you started. The services that a Web marketing Company provides aren't consistently one thing concrete that individuals may observe, although points like streamer advertisements and also social networking sites advertising (using web sites like MySpace) are actually pretty apparent. If you loved this posting and you would like to obtain more data pertaining to yellow pages online residential uk [http://runen--bfree.info/] kindly take a look at the website. As an example, there is just what may be taken into consideration straight advertising and marketing and secondary advertising. The MA Strategic Manner Marketing gives a learning setting in which service graduates may create both artistic and also important capabilities in vogue marketing and management. Some of the biggest factors for you to know is Search Engine Optimization, as well as exactly how Search Engine Optimization, SEM and social networking sites marketing are all extremely other. If you combine a constant follow-up technique in to your advertising and marketing activities, it will certainly allow people to understand, like and also trust you; give them details that they can easily use; display the market value and outcomes you can supply, as well as naturally, see your sales go up! So that is crystal clear a fact that you need to commit maximum sources in getting the most effective advertising and marketing service. The progression of appropriate employability abilities is at the primary of the BSc Hons Accountancy and also Advertising degree as well as a selection of chances exist within the programme, and also its elements, to create such capabilities. Promotional branded things are actually an incredibly creative advertising and marketing approach as well as, understood by businesses everywhere, to be very efficient. The conflation of online search engine Advertising and marketing and also Ppc (Pay Per Click) initiatives offers a successful information to market your product on world-wide web. Today, Web marketing is looked at as really faster and also money-saving medium for marketing item and company growth. The most ideal advertising internships will definitely enable you to apply the marketing know-how that you have found out in institution and will present you the globe with genuine marketing expertise. My placement was with a pharmaceutical company phoned Baxter as well as that has delivered me with reality knowledge from working in a marketing team for a multi-million extra pound worldwide provider dealing with various product launches, exhibitions, Public Relations as well as advertising and marketing initiatives. Possessing an advertising strategy in position just before you begin anything can be a necessity of your results in World Financial Team. The 2nd part will then check out the different components from the advertising communications mix. This element will examine item monitoring as well as product development tactics within the advertising and marketing method. Your advertising and marketing message is what creates the background of all your marketing techniques and interactions. A successful digital advertising and marketing meeting includes the participation of top-level experts coming from the industry. Read on more and learn more about some even more of the advertising and marketing suggestions as well as methods so as to manage this specific service collection of a relocating provider properly. But regardless of exactly how dumb that could be, it may be a truth that some are actually birthed as invalid planning setter. If you didn't possess a mobile phone advertising and marketing tactic, as well as in order to permit your consumers recognize you are actually possessing a purchase, you would certainly have to operate an add in the newspaper, pay for ads on TV, operate an add on the radio, deliver email outs or some other methods to allow all of them understand. This component will definitely offer you a good understanding of primary marketing administration guidelines and also just how these are actually put on individuals, industrial solutions and also companies, each coming from a theoretical and also an efficient perspective. And ofcourse this is not mosting likely to be your only marketing strategy yet this will be actually a great technique to enhance your existing approaches. The internationalisation from retailer/brands marketing approaches are going to be discovered to help brand new multi-channel/ omni-channel as well as digital routes to market for reputable and also surfacing markets.

[blogwiseguy123world]

Global DNA Vaccine Market Research Report 2020-2025

Summary – A new market study, titled "Global DNA Vaccine Market Research and Forecast, 2018-2023" has been featured on WiseGuyReports.

DNA vaccines Market are the third generation vaccines that designed to overcome the undesirable properties of conventional vaccines. The increasing exposure of population to infectious diseases and increasing number of antibiotics resistant pathogens have created the need for effective and low-cost vaccination, which would provide long lasting immunity. DNA vaccines have low risk of infection, easy transportation and stability at room temperature and hence are advantageous over traditional vaccines. DNA vaccines target a wide range of traditional pharmaceutical markets, such as cancers and allergies, as well as infectious diseases

Also read – https://www.medgadget.com/2019/05/dna-vaccine-market-2019-by-manufacturers-regions-type-and-application-forecast-to-2023.html

The global DNA vaccines market is experiencing rapid growth owing to the factors such adoption of DNA vaccines in healthcare, low costs of DNA vaccines, and increasing investments in DNA technology. The increase in the prevalence of chronic diseases such as cancer, hepatitis, HIV and others are augmenting the growth of the global DNA vaccine market. Moreover, relative ease of large-scale manufacturing compared to traditional approach and less storage requirement are some of the key market drivers. The other factors augmenting the growth of the market includes increasing clinical trials for DNA vaccines both animal based and human based. Several DNA vaccine clinical trials have been recently completed or are currently ongoing, such as ZYC101 (Eisai Pharmaceuticals) has completed phase I trial. HPV-16 and HPV-18 E6/E7 are being evaluated in a phase I clinical trial (Inovio Pharmaceuticals). DNA vaccines have already made significant progress to date. Nearly 100 clinical trials are on-going in humans for a wide range of diseases, and there is a deep pipeline of preclinical projects.

However, uncertainty in regulatory policies and less penetration of DNA vaccine technology in the emerging economies is hindering the growth of the market. However, the increasing benefits offered by the DNA based vaccines and increasing awareness will have a positive impact on the growth of the market in the future.

The DNA vaccine market is segmented on the basis type, technology and application. On the basis of type, the market is segmented into animal DNA vaccine and human DNA vaccine. On the basis of technology, the market is bifurcated into Plasmid DNA vaccine and plasmid DNA delivery technology. On the basis of application, the market is divided into oncology, infectious diseases and others. The market for oncology based DNA vaccines and Infectious diseases is one of the largest segment for the DNA based vaccines. Clinical trials for DNA vaccines to treat cancer including metastatic melanoma, prostate, and pancreatic cancer, and other solid tumors, are showing promising results. Inovio Pharmaceuticals has also been working on a DNA-based vaccine for Zika since December 2015.

The global DNA vaccine market is analysed on the basis of the geographical regions that are contributing significantly towards the growth of the market. North America dominates the global DNA vaccine market due to the presence of all the major key pharmaceutical companies and increasing clinical trials. Europe is the second largest market followed by Asia pacific region. Asia pacific is the fastest growing segment due to increasing awareness about the benefits and flexibility offered by DNA vaccines.

The companies contributing to the growth of global DNA vaccine market are Astellas Pharma, Bharat Biotech, Dendreon Corporation, Indian Immunologicals Limited, GE Healthcare Life Sciences, GlaxoSmithKline Inc., Green Cross Corporation, Innovio Biomedical Corporation, Pfizer Pharmaceuticals, Sanofi, The Serum Institute of India Pvt. Limited, Zoetis Inc. and so on. US – AgriLabs in November 2017, announced the United States Department of Agriculture (USDA) approval of the first DNA vaccine licensed for chickens. The approval also represents the first for AgriLabs ExactVacTM DNA technology with ENABL adjuvant, the first DNA vaccine approved for influenza for veterinary use, and among the first DNA vaccines approved in the US for food animals.

• Global DNA vaccines market by type

• Global DNA vaccines market by technology

• Global DNA vaccines market by application

Research Methodology

The market study of DNA vaccine market is incorporated by extensive primary and secondary research conducted by research team at OMR. Secondary research has been conducted to refine the available data to breakdown the market in various segments, derive total market size, market forecast and growth rate. Different approaches have been worked on to derive the market value and market growth rate. Our team collects facts and data related to the market from different geography to provide a better regional outlook. In the report country level analysis is provided by analyzing various regional players, regional tax laws and policies, consumer behavior and macro-economic factors. Numbers extracted from Secondary research have been authenticated by conducting proper primary research. It includes tracking down key people from the industry and interviewing them to validate the data. This enables our analyst to derive the closest possible figures without any major deviations in the actual number. Our analysts try to contact as many executives, managers, key opinion leaders and industry experts. Primary research brings the authenticity in our reports.

Secondary sources include:

• Financial reports of companies involved in the market

• Authentic Public Databases

• Whitepapers, research-papers and news blogs

• Company websites and their product catalogue.

• Supplier Websites such as Alibaba, amazon for pricing analysis.

The report provides in-depth analysis on pricing, market size, intended quality of the product preferred by consumers, initial norms and vehicle segment. The report will serve as a source for 360-degree analysis of the market thoroughly integrating different models such as PEST analysis, Porter five analysis delivering insights into the market for better business decisions.

THE REPORT COVERS:

• Comprehensive research methodology of Global DNA Vaccine Market.

• This report also includes detailed and extensive market overview with Analyst insights & key market trends.

• Exhaustive analysis of macro and micro factors influencing the market guided by key recommendations.

• Analysis of regional regulations and other government policies impacting the Global DNA Vaccine Market.

• Insights about market determinants which are stimulating the Global DNA Vaccine Market.

• Detailed and extensive market segments with regional distribution of forecasted revenues.

• Extensive profiles and recent developments of market players.

For more details - https://www.wiseguyreports.com/reports/3186874-global-dna-vaccine-market-research-and-forecast-2018-2023

About Us:

Wise Guy Reports is part of the Wise Guy Research Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe.              

Contact Us:

NORAH TRENT                                                      

sales@wiseguyreports.com      

Ph: +162-825-80070 (US)                        

Ph: +44 2035002763 (UK)  

[titheguerrero]

Celebrating 10 Years of Health Populi, 10 Healthcare Milestones and Learnings

Happy anniversary to me…well, to the Health Populi blog! It’s ten years this week since I launched this site, to share my (then) 20 years of experience advising health care stakeholders in the U.S. and Europe at the convergence of health, economics, technology, and people.

To celebrate the decade’s worth of 1,791 posts here on Health Populi (all written by me in my independent voice), I’ll offer ten health/care milestones that represent key themes covered from early September 2007 through to today…

1. Healthcare is one-fifth of the national U.S. economy, and the top worrisome line item in the American family’s pocketbook. You can read more about this in Health Populi from day 1 in 2007 to late August 2017 with more evidence that health care costs are top-of-mind for U.S. health citizens. For the immediate future, patients will assume a greater share of health care spending given employers’ growing adoption of consumer-directed health plans — high-deductibles coupled with health savings accounts.

2. The Affordable Care Act worked to get health insurance to millions of uninsured Americans. But there is more work to do, and this week Congress re-convenes with some evidence of green shoots of bipartisan cooperation to fix, not repeal, the ACA. American workers highly value their health benefits, well-knowing how much it could cost them to fetch health plans on the individual market. As President Trump recently cut the Federal ACA budget for communicating health insurance marketplace options, the U.S. faces a situation where the nation’s President may be mindfully contributing to Americans’ reduced access to being health-insured by reducing access and on-ramps to consumers’ needed information. But State and local insurance navigators are working to fill this gap.

3. Sticker-shock is a mainstream reaction for American patients who fill branded prescription drugs. The course of a drug treatment to cure Hepatitis C reached $98,000 in 2014. The retail price of an EpiPen, $500 in 2016, driving angry patients in New York City to protest in front of Mylan’s offices. The latest entry into the pharma cost Hall of Fame is Kymriah, a new-new gene therapy treatment for treating young people with acute lymphoblastic leukemia, approved by the FDA last week. ALL is the most common form of cancer in young people. The list price will be $475,000 for a one-time treatment. Lowering the cost of prescription drugs is one health reform issue Americans across the political spectrum agree on.

4. Most patients’ personal health information has moved from manila paper folders with hand-written notes to digitized, electronic health records. Most patients want to connect with their physicians using digital means, but privacy concerns remain. Trust must be earned to garner health engagement, as I recently discussed in light of Aetna’s breach of peoples’ HIV status in a mailed letter. Still, we know from research via the PatientsLikeMe community and other patient social networks that people managing serious diseases are willing to share personal health information when there is a value-exchange.

5. More personal health information is being generated through wearable technology. In the past decade, I’ve attended the annual CES (the acronym once fully called out as the Consumer Electronics Show). Beyond big-screen TVs and tricked-out cars, one of the fastest-growing areas at CES is digital health. While Fitbit wrist bands and Withings Wi-Fi scales represented the early generation of wearable tech for health (or mHealth), shiny new things are emerging via Apple Watch and heart-activity enhancements that are gathering data that’s getting stored in clouds (Amazon Web Services and Apple to Samsung and dozens of others). Data are mashed into algorithms that can then inform patients, consumers, caregivers, and clinicians to coach and inform decisions.

6. Beyond wearing tech, our homes and autos (the so-called “third space”) are getting filled with “things” in the growing Internet of Things environment. Light bulbs, washing machines, refrigerators and, of course, voice-powered digital assistants (THINK: Amazon Echo and Alexa) have begun to collect data on our daily habits, and health is already growing its IoT chops.

7. Virtual health and telehealth have passed a tipping point for adoption. This very minute as I write this post, telehealth technology is helping thousands of people in Texas hurt by Hurricane Harvey get needed healthcare and medical attention sooner rather than later.

8. Health is social. Health is contagious. So are negative health behaviors. The research of Christakis and Fowler published in their book, Connected, demonstrates that people can kick-off a virtuous cycle of health for themselves that influences not only their immediate social network of friends and family, but positively influences their networks further out in the social web. This is at the root of public health: we are our brothers’ and sisters’ keepers, and this is the evidence for why social determinants of health are so powerful in communities. Loneliness is also a social determinant of health, as I wrote here about new research into our purpose and our wellness.

9. Health disparities continue to mar American health care. People of color and lower-income people have worse health outcomes, and for many conditions and procedures, less access to the latest evidence-based standards of care. This year marked 50 years since the 1967 Detroit riots, and 70 years since the Nuremburg Code emerged. Health care in the U.S. must confront these health inequities and bring greater “health symmetry” to all health citizens in the nation. Aside from issues of justice, a healthy citizenry is a productive one that generates tax revenue for a nation.

10. Patients are morphing into health care consumers, seeking transparency, management tools, information, and support from both health industry players and from each other, in peer-to-peer networking. Amazon has “primed” health care consumers, and will be taking its place among the new entrants helping to improve peoples’ health care experiences. Consumers’ most recent excellent experience in retail defines their current benchmark for expectations in all sectors — including health care.

I must thank two colleagues who first inspired me to launch the Health Populi blog: Matthew Holt and Bob Laszewski. Matthew, who founded The Health Care Blog in 2003, was my first close colleague to blog about health care. He provided early counsel to me on two issues: finding my authentic voice (which he certainly has), and warning against allowing the blog to be a major time-suck in daily life. Bob, a Washington, DC-based health policy expert, set an example of authenticity, passion, and fact-based reporting in his blog, Health Care Policy and Marketplace Review, founded in 2006.

Health Populi’s Hot Points:  The ten milestones listed here drive home several things “I know that I know,” learnings I’ve derived from my many years of working with clients across the health and healthcare landscape — traditional healthcare organizations and suppliers (hospitals, physicians, health plans, medical device, and pharmaceutical companies) to newer entrants including consumer goods, food, electronics, and financial services, among them.

Healthcare is morphing toward health/care in a landscape where healthcare providers and traditional stakeholders (plans, suppliers, pharma) must inter-operate with new entrants — from Amazon to ZocDoc. That’s a good thing, because heath care consumers want care served up how and where we want it — and provided in a value-based framework. In that context, let me tell you what I know I know:

Noncommunicable diseases – heart, diabetes, cancers, among them – will kill most of us in 2017. These conditions are largely amenable through self-care and lifestyle changes such as quitting smoking, eating nutritious foods in right-sized portions, taking more activity and exercise, and moderately drinking alcohol.

To ensure healthy health citizens, spending money and labor on the social determinants of health are more important, dollar for dollar, than specialized tertiary healthcare services. See this article just published in the aftermath of Hurricane Harvey, on why investing in prevention, broadly writ, is crucial for a healthy nation. [It’s written by one of my favorite public health policy folks, Dr. Sandro Gallea.]

(Good) food is medicine. Starting people in life with nutrition, pre-natally and ongoing, is a huge health boost and a key social determinant of health for a lifetime. [My friends at SquareRoots, with whom I collaborated on a maternal and child health panel at CES 2016, are working on this.]

Mental health is core to overall health and well-being, just like heart health, gut health, bone health, and oral health. Bundling mental health into primary care would help improve America’s behavioral health crisis….coupled with greater resource allocation toward social care away from more expensive specialty healthcare spending.

The world’s developed countries that have invested in strong primary care backbones (supply of physicians, nurses, and other primary care provider types) have patients with better health outcomes. The U.S. spends relatively less per capita on primary care than these other countries, and our health outcomes fall well below those in Denmark, France, and even the UK — which spends far less per person on healthcare than the U.S. does.

As I look toward the next ten years of my work, trend-weaving and writing, I expect our houses (whether single family, apartment, or Tiny) will evolve into our true medical homes, where we take on greater self-care enhanced through Internet of Things, artificial intelligence, and enhanced health literacy. What will underpin this is greater attention to designing care processes, “things,” and experiences that speak to peoples’ own health literacy, values and preferences. “Personalized medicine,” in terms of genomics, has gained a lot of attention and resources. A greater focus and resourcing toward “personalized health” that accounts for our individual values and belief systems, socioeconomic status and preferences, will bolster health outcomes for all health citizens in the U.S.

The post Celebrating 10 Years of Health Populi, 10 Healthcare Milestones and Learnings appeared first on HealthPopuli.com.

Article source:Health Populi