#Hydrochloric acid ar grade

[marutifinechemicals]

Exploring the Versatility of Hydrochloric Acid AR Grade — Maruti Fine Chemicals

Hydrochloric acid, commonly known as HCl, is a strong, colorless, corrosive mineral acid used in various industrial and laboratory applications. It is highly soluble in water and forms hydrogen chloride gas when dissolved. Maruti Fine Chemicals offers two grades of Hydrochloric acid: AR (Analytical Reagent) Grade and LR (Laboratory Reagent) Grade. Let’s delve into the characteristics, applications, and differences between these two grades.

Hydrochloric Acid: AR Grade

Hydrochloric acid ar grade, also known as Analytical Reagent Grade, is a high purity form of the acid suitable for analytical and research purposes. It is meticulously manufactured to meet stringent purity standards, ensuring minimal impurities that could interfere with analytical procedures. AR Grade HCl typically has a concentration ranging from 30% to 37%, with specifications for trace metal content and other impurities.

Applications of Hydrochloric Acid AR Grade:

Hydrochloric Acid: LR Grade

Hydrochloric acid lr grade, or Laboratory Reagent Grade, is a high-quality grade suitable for general laboratory applications. While it may not meet the stringent purity requirements of AR Grade, LR Grade HCl still offers high purity and is suitable for most laboratory applications. LR Grade HCl typically has a concentration ranging from 30% to 32%.

Applications of Hydrochloric Acid LR Grade:

General Laboratory Use: LR Grade HCl finds application in various laboratory procedures requiring a reliable source of hydrochloric acid. Synthesis: It is used in the synthesis of various chemicals and compounds in laboratory settings. pH Adjustment: Similar to AR Grade, LR Grade HCl is utilized for pH adjustment in solutions.

FAQs:

Q 1. What is the difference between AR Grade and LR Grade Hydrochloric acid?

The main difference lies in their purity levels. AR Grade Hydrochloric acid is of higher purity, suitable for analytical and research purposes, while LR Grade HCl is of slightly lower purity but still suitable for general laboratory applications.

Q 2. Can I interchange AR Grade and LR Grade Hydrochloric acid in laboratory procedures?

In most cases, yes. However, for highly sensitive analytical procedures where trace impurities could affect results, it’s advisable to use AR Grade Hydrochloric acid.

Q 3. Are there any safety precautions to consider when handling Hydrochloric acid?

Yes, Hydrochloric acid is corrosive and can cause severe burns upon contact with skin or eyes. Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn when handling it. Additionally, it should be used in a well-ventilated area to prevent inhalation of fumes.

Q 4. How should Hydrochloric acid be stored?

Hydrochloric acid should be stored in tightly sealed containers away from heat, direct sunlight, and incompatible substances. It should be kept in a well-ventilated area, preferably in a dedicated acid storage cabinet.

Q 5. Can Hydrochloric acid be disposed of down the drain?

Conclusion:

In conclusion, Hydrochloric acid AR grade and LR Grades serves essential roles in laboratory and industrial settings. Choosing the appropriate grade depends on the specific requirements of the application, with AR Grade offering higher purity for analytical purposes and LR Grade providing a reliable option for general laboratory use. Proper handling and storage are imperative to ensure safety and maintain the integrity of laboratory procedures involving Hydrochloric acid.

[ases012345]

Laboratory Chemical Suppliers in India: The Backbone of Scientific Research and Industry

In India, the role of laboratory chemical suppliers is crucial across a wide range of industries, from research and development to pharmaceuticals, food safety, and environmental testing. These suppliers provide a comprehensive range of chemicals, reagents, solvents, and other essential materials that are used in laboratories for a variety of purposes. With India being a hub for scientific advancement and innovation, the need for high-quality, reliable chemical suppliers has never been more significant.

What Do Laboratory Chemical Suppliers Do?

Laboratory chemical suppliers provide a wide array of chemicals that are critical to laboratory processes. They ensure the availability of the right chemicals in the right quantities and purity levels. This includes everything from basic reagents used in chemical reactions to advanced specialty chemicals needed for complex research projects.

The role of these suppliers goes beyond just providing chemicals. They are also responsible for ensuring the safety, proper handling, and storage of hazardous substances. Most reputable suppliers comply with industry regulations and standards, ensuring that the chemicals they supply meet the highest safety and quality requirements.

Why Are Laboratory Chemical Suppliers Important?

Support for Research and Innovation: India is home to numerous research institutions, universities, and laboratories that rely heavily on a constant supply of quality chemicals. Whether it’s for testing, analysis, or experiments, a steady supply chain of chemicals is essential for the progress of scientific research.

Contributing to the Pharmaceutical Industry: The pharmaceutical sector in India is one of the largest and most advanced in the world. Laboratory chemical suppliers play a key role in the development of medicines by providing chemicals needed for the synthesis of active pharmaceutical ingredients (APIs), excipients, and other components required for drug formulation.

Food and Beverage Safety: In the food and beverage industry, chemicals are used for quality control, preservation, and testing for contaminants. Suppliers that provide food-grade chemicals ensure that these substances meet strict regulatory standards to protect consumer health.

Environmental Testing: The growing emphasis on environmental protection means that more laboratories are conducting tests to monitor air, water, and soil quality. Laboratory chemical suppliers provide essential chemicals needed for these environmental assessments, helping to identify pollutants and safeguard public health.

Ensuring Consistency and Reliability: One of the biggest challenges for laboratories is maintaining consistency in their results. Reliable laboratory chemical suppliers ensure that chemicals are consistent in terms of quality, concentration, and shelf life. This reliability is critical for obtaining accurate and reproducible results in experiments and tests.

Key Chemicals Supplied by Laboratory Chemical Suppliers

Laboratory chemicals can be categorized into several groups, each serving a unique function in laboratory experiments. Some of the most common chemicals supplied by laboratory suppliers include:

Acids and Bases: These are fundamental reagents used in a variety of chemical reactions and processes. Examples include hydrochloric acid, sulfuric acid, sodium hydroxide, and ammonia.

Solvents: These are used to dissolve other substances, and some common solvents are water, ethanol, acetone, and methanol. Solvents play an essential role in many organic and inorganic reactions.

Buffers: These chemicals maintain the pH level of a solution, which is vital for many biochemical processes. Examples include phosphate buffer and tris buffer.

Reagents for Analysis: These include substances used in analytical procedures, such as indicators, titrants, and reagents for spectroscopy and chromatography.

Specialty Chemicals: These are more complex chemicals used in specialized applications, such as in pharmaceuticals or biotechnology. These can include catalysts, enzymes, and reagents for genetic research.

Choosing the Right Laboratory Chemical Supplier in India

When selecting a laboratory chemical supplier, there are several factors to consider:

Quality and Purity: The quality of the chemicals is paramount, as impurities can affect the results of experiments. Reliable suppliers provide certificates of analysis (COA) and ensure that their chemicals meet international standards.

Compliance with Safety Regulations: It’s essential to choose a supplier that adheres to safety regulations and provides the necessary safety data sheets (SDS) for their chemicals. This helps laboratories follow proper safety protocols when handling potentially hazardous substances.

Reputation and Experience: Established suppliers with a good track record are more likely to provide consistent, high-quality products. Look for companies with years of experience and positive reviews from customers in relevant industries.

Availability and Timeliness: A supplier with a fast and reliable delivery system ensures that laboratories don’t face any delays in receiving the chemicals they need. Timeliness is crucial, especially when working with perishable or time-sensitive materials.

Cost-Effectiveness: While price should not be the only factor, it’s important to balance quality with affordability. A reputable supplier will offer competitive prices without compromising on the quality of the chemicals they provide.

Conclusion

Laboratory chemical suppliers in India are essential partners in the fields of research, manufacturing, testing, and development. They provide the necessary materials to drive innovation and support various industries, from pharmaceuticals to food safety and environmental protection. Whether you’re involved in scientific research, quality control, or production, choosing the right supplier is crucial to ensuring that your work is accurate, efficient, and safe. By considering factors like quality, reliability, compliance, and experience, laboratories can find a trusted chemical supplier that meets their needs and supports their long-term goals.

[omc-juniperpublishers]

Design, Synthesis of Novel Thieno [2,3-d] derivatives and their Anti-Microbial studies-JuniperPublishers

Journal of Chemistry-JuniperPublishers

                              Abstract

A new series of 4-Substituted/Heterocyclic -N-(4-(4-(trifluoromethyl/Nitro)phenoxy)thieno[2,3-d]pyrimidin-2-yl)benzamide (8 a-j) derivatives were synthesized by a five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. Several Thieno [2,3-d] Pyrimidines have been prepared from methyl 2-aminothiophene-3-carboxylate(1).The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) from Gram positive group of bacteria. Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) from Gram negative group of bacteria. Anti-fungal activity against Aspergillus Niger (A. Niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin & Flucanazole. From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8h and 8g possess good activity.

Keywords: Thieno [2, 3-d] Pyrimidine, Acid-amine coupling reaction, 2, 4-di chloro Thieno [2, 3-d] Pyrimidine, Anti-microbial activity

Introduction

Thieno Pyrimidine is a bi cyclic heterocyclic compound consists of a five membered thiophene ring is fused to a six membered hetero cyclic ring with two nitrogen atoms. The fusion may occur in three different orientations that results in three important types of thienopyrimidines namely;

a) Thieno[2,3-d]Pyrimidine

b) Thieno[3,2-d]Pyrimidine and

c) Thieno[3,4-d]Pyrimidine

Most of the isomeric Thieno Pyrimidine occurs as colored amorphous form, some exists as crystalline form. Synthetic approaches for the construction of a number of Thieno Pyrimidines are well established. There exists three possible types of fusion of thiophene to Pyrimidine ring results in corresponding isomeric Thieno pyrimidines namely; (Figure 1) Thieno[2,3-d] pyrimidines (a), Thieno[3,4-d]pyrimidines (b) and Thieno [3,2-d] pyrimidines (c).

As a logical consequence of thiophene-phenyl isosterism, similarly Thieno pyrimidines can be considered as bio isosteres of quinazolines, which are extensively described in scientific and patent literature as displaying a plethora of biological activities. The synthesis of Thieno pyrimidine derivatives as potential surrogates for the quinazoline core structure has therefore, become a routine strategy in modern drug design and development. Thieno pyrimidines as isosteres of quinazolines are shown here (Figure 2). Thienopyrimidines can also be considered as structural analogues of five-membered heterocycles such as purines and thiazolo-pyrimidines. As interesting anti-HIV activity was discovered within the thiazolo [5,4-d]pyrimidine series, whereas the thiazolo[4,5-d] pyrimidines lack antiretroviral activity. The structures of purines and thiazolo pyrimidines are shown in the following (Figure 3).

Thiophene containing compounds are well known to exhibit various biological effects. Heterocycles containing the Thieno pyrimidine moiety are of interest because of their interesting pharmacological and biological activities [1-3]. They bear structural analogy and iso electronic relation to purine and several substituted Thieno [2,3-d] Pyrimidine derivatives shown to exhibit prominent and versatile biological activities [4,5]. Over the last two decades, many Thieno-pyrimidines have been found to exhibit a variety of pronounced activities. Many of their derivatives have been synthesized as potential anticancer [6], analgesic [7], antimicrobial [8,9] and antiviral agents [10].

Some reviews on Pyrimidine thiones [11] and condensed pyrimidines, namely pyrazolo-pyrimidines [12] and furo- pyrimidines [13]. Thieno-pyrimidines are interesting heterocyclic compounds and a number of derivatives of these compounds display therapeutic activity as antimicrobial [14-17], anti-viral [18-19], anti-inflammatory [20-21], anti-diabetic [22], anti-oxidant [23], anti-tumour [24-28] and anti-cancer agents [29-30], anti-depressant [31], anti-platelet [32], anti-hypertensive [33], herbicidal [34] and plant growth regulatory properties [35].

Literature survey revealed that incorporation of different groups in Thieno [2,3-d]pyrimidine Heterocyclic ring enhanced antibacterial and antifungal activity. In the present communication 2,4- di chloro Thieno[2,3-d] Pyrimidine (3) was reacted with various Phenols 4(a-b) in Acetone to form 2-chloro- 4-(4-(trifluoro methyl)phenoxy)Thieno[2,3-d]Pyrimidine (5a-b) , which was further converted in to amine by using aqueous Ammonia to form compounds (6a-b), which was reacted with different Substituted Carboxylic acids (7 a-e) under Acid-amine Coupling reaction reagent to get target compounds (8a-8j). Encouraged by the diverse biological activities of novel Thieno [2, 3-d] Pyrimidine derivatives, it was decided to prepare a new series of derivatives of Thieno [2, 3-d] Pyrimidine as a core unit. The synthesis of the compounds as per the following (Scheme 1) given below. The synthetic route was depicted in scheme 1. The structures of all synthesized compounds were assigned on the basis of IR, Mass, 1H & 13C NMR spectral data analysis. Further these compounds were subjected for antifungal and antibacterial activity.

Materials and Methods

In this Investigation chemicals were purchased from local dealer with Alfa aesar & Avra labs make was used. Chemicals were 99 % pure; purity has been checked by thin layer chromatography and melting point. Conventional method has been used for synthesis of Thieno [2, 3-d] Pyrimidine derivatives. Stirring and reflux method were used for synthesis of Thieno [2, 3- d] Pyrimidine derivatives 8 (a-j) respectively. The synthetic route was depicted in (Scheme 1). The title compounds 8(a-j) were synthesized in five sequential steps using different reagents and reaction conditions, the 8(a-j) were obtained in moderate yields. The structure were established by spectral (IR, JH-NMR, 13C-NMR and mass) data (Scheme 1).

Reagents and Reaction conditions:

a) 5 eq Urea, 190OC, 3 hrs

b) POCl3, Reflux, 6 hrs

c) Sodium hydroxide in water, acetone (1:1 ratio), 080°C; 24 h

d) Aqueous Ammonia,90OC, 6hrs

e) HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3- triazolo[4,5-fr]pyridinium 3-oxide hexa fluoro phosphate), Hunig,s base (N,N-di isopropyl ethylamine) , DMF, RT,16hrs (Figure 4).

Steps:

a. The base deprotonates the carboxylic acid. The resulting carboxylate anion attacks the electron deficient carbon atom of HATU.

b. The resulting HOBt anion reacts with the newly formed activated carboxylic acid derived intermediate to form an OBt activated ester.

c. The amine reacts with the OBt activated ester to form the amide bond.

Experimental Section

All reactions were carried out under argon in oven-dried glassware with magnetic stirring. Unless otherwise noted, allmaterials were obtained from commercial suppliers and were used without further purification. All solvents were reagent grade. THF was distilled from sodium benzo phenone ketyl and degassed thoroughly with dry argon directly before use. Unless otherwise noted, organic extracts were dried with anhydrous Na2SO4, filtered through a fitted glass funnel, and concentrated with a rotary evaporator (20-30 Torr). Flash chromatography was performed with silica gel (200-300 mesh) by using the mobile phase indicated. The NMR spectra were measured with a 400 MHz Bruker Avance spectrometer at 400.1 and 100.6 MHz, for 1H for 13C, respectively, in CDCl3 solution with tetra methyl silane as internal standard. Chemical shifts are given in ppm (δ) and are referenced to the residual proton resonances of the solvents. Proton and carbon magnetic resonance spectra (1H NMR and 13C NMR) were recorded using tetra methyl silane (TMS) in the solvent of CDCl3-d1 or DMSO-d6 as the internal standard (1H NMR: TMS at 0.00 ppm, CDCl3 at 7.26 ppm ,DMSO at 2.50 ppm; 13C NMR: CDCl3 at 77.16 ppm, DMSO at 40.00 ppm).

Synthesis

General procedure for synthesis of Thieno [2, 3-d] pyrimidine-2, 4-diol [compound (2)]

A mixture of Methyl 2-aminothiophene-3-carboxylate (0.13 mol, 20g) and urea (1 mol, 60g) were mixed with each other, and the mixture was heated for two hours at 200° C. A clear, brown molten mass was formed which solidified upon standing; the solid product was dissolved in warm 1 N sodium hydroxide, and then acidified with 2 N Hydrochloric acid. The crystalline precipitate formed thereby was collected by vacuum filtration and re crystallized from Water, yielding 65% (13.8 gms) of Thieno [2, 3-d] pyrimidine-2, 4-diol.

Yield: 65% (white colour solid);

IR (KBr, cm-1): 3260(N-H Stretching], 3125(Ar C-H], N-O (1140 & 1350), 1680.50 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.20 (d, 1H, J=7.1HZ), 6.98(1H, d, J=7.1HZ], 7.65(2H,d, J=7.3HZ], 8.15(2H, d, J=7.3HZ], 9.25(1H,bs], 7.91(2H,d, J=7.3 HZ], 8.95 (2H,d, J=7.3 HZ] .

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55, 158.8, 168.34, 172.65.

ESI-MS m/z = 394.465 [M+H] +.

N-(4-(4-nitrophenoxy) Thieno [2,3-d]pyrimidin-2- yl)thiophene-2-carboxamide (8j): (Figure 6.5.10). This compound was obtained as off-yellow solid in 70% yield. m.p. 253-256OC.

IR (KBr, cm-1): 740(-C-Cl), 3110(Ar C-H), 1660 (Ar C=C Stretching).

1H NMR (400 MHz; CDCl3): δH 7.65 (d, 1H, JHH = 6.5 Hz, Ar- H), 7.45 (d, JHH = 6.5 Hz, 1H, Ar-H).

13C NMR (100 MHz; CDCl3): δC 126.92, 123.03, 126.11,153.62, 161.67, 154.75.

GC-MS: RT at 10.968 (100%), m/z = 204(M+H) +, 206(M+2),208(M+4), 9:6:1 it indicates molecule contain two chlorine atoms (Figures 5 & 6).

General procedure for synthesis of 2-chloro-4-(4- (trifluoro methyl)phenoxy)Thieno[2,3-d]Pyrimidine (5a), 2-chloro-4-(4-nitrophenoxy) Thieno [2,3-d] Pyrimidine(5b)

5g (24.5 m.mol) 2, 4-dichloro Thieno [2, 3-d] Pyrimidine (3) dissolved in 50 ml of acetone are slowly added to a solution of 5.32g(130 m.mol) NaOH and 4g(24.5 m.mol) 4-(tri fluoro methyl) phenol(4a)/3.4g 4-nitrophenol (4b) in 100 ml H2O at OOC. After stirring for 24 h at 70OC, the reaction mixture is concentrated under reduced pressure, cooled and the precipitated crude product is filtered off, washed with H2O and dried in vacuum. Purification is performed by flash chromatography (SiO2 Hexane/ EtoAc 2:1).

2-chloro-4-(4-(tri fluoro methyl) phenoxy) Thieno[2,3-d] Pyrimidine (5a):

1H NMR (DMSO-d6) (δ/ppm) δ ppm): 7.25 (d, 1 H, J=7.2HZ), 7.10(1H, d, J=7.2HZ), 7.2 5(1H,d, J=7.1HZ), 7.65(2H, d, J=7.1HZ).

13C NMR (DMSO-d6) (δ/ppm): 123.55, 125.15, 127.65,

128.55, 155.35, 158.55.

IR (KBr, cm-1): Ar stretch C-H (3110), C=N (1646.15), C-F (1345), C-Cl(739),C-O (1362).

ESI-MS m/z 331[M+H]+ .

2- chloro-4-(4-nitrophenoxy) Thieno [2, 3-d] Pyrimidine (5b):

1H NMR (DMSO-d6) (δ/ppm) δ ppm): 7.25 (d, 1 H, J=7.1HZ), 6.95(1H, d, J=7.1HZ), 7.45(2H, d, J=6.7HZ), 8.15(2H, d, J=6.7HZ).

13C NMR (DMSO-d6) (δ/ppm): 123.55, 125.15, 127.65,128.55, 143.55, 155.35, 158.55, 175.55. IR (KBr, cm-1): Ar stretch C-H (3110), N-O (1140 & 1325), C-Cl (730).

ESI-MS m/z 308[M+1].

General procedure for synthesis of 4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d] pyrimidin-2-amine(6a), 4-(4-nitrophenoxy)Thieno[2,3-d]pyrimidin-2-amine (6b)

A solution of 25% aqueous ammonia solution (5 mol) and compounds (5a-5b) (1 mol) was stirred at 90OC for 5h. The precipitate was collected by filtration and washed with water and dried to give compounds (6a-6b).

4-(4-(trifluoromethyl)phenoxy)Thieno[2,3-d ] pyrimidin-2-amine(6a):

1H NMR (DMSO-d6) (δ/ppm) δ ppm): 7.05 (d, 1 H, J=7.1HZ), 7.10(1H, d, J=7.1HZ), 7.45(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 6.75(2H,bs).

13C NMR (DMSO-d6) (δ/ppm): 123.55, 125.15, 127.65,128.55, 155.35, 158.55, 163, 173.6.

IR (KBr, cm-1): Ar stretch C-H (3110), C=N (1656.15), C-F (1365), N-H (3339 & 3445),C-O (1352).

ESI-MS m/z 312[M+1].

4-(4-nitrophenoxy)Thieno[2,3-d]pyrimidin-2-amine (6b):

1H NMR (DMSO-d6) (δ/ppm) δ ppm: 7.15 (d, 1 H, J=7.2HZ), 6.90(1H, d, J=7.2HZ), 7.45(2H,d, J=7.3HZ), 8.15(2H, d, J=7.3HZ), 6.95(2H,bs).

13C NMR (DMSO-d6) (δ/ppm): 123.55, 125.15, 127.65,128.55, 145.35, 158.55, 163, 173.6.

IR (KBr, cm-1): Ar stretch C-H (3110), N-O (1140 & 1325), N-H(3339 & 3445).

ESI-MS m/z 289[M+1].

General procedure for synthesis of 4-methyl-N- (4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d] pyrimidin-2-yl)benzamide (8a),4-methoxy-N-(4-(4- (trifluoromethyl)phenoxy)thieno[2,3-d]pyrimidin-2- yl)benzamide(8b),N-(4-(4-(trifluoromethyl)phenoxy) thieno[2,3-d]pyrimidin-2-yl)pyrazine-2-carboxamide (8c),  N-(4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d] pyrimidin-2-yl)isonicotinamide(8d), N-(4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d]pyrimidin- 2-yl)thiophene-2-carboxamide (8e), 4-methyl-N- (4-(4-nitrophenoxy)thieno[2,3-d]pyrimidin-2-yl) benzamide(8f),4-methoxy-N-(4-(4- nitrophenoxy) Thieno[2,3-d]pyrimidin-2-yl)benzamide (8g), N-(4- (4-nitrophenoxy)thieno[2,3-d]pyrimidin-2-yl) pyrazine-2-carboxamide (8h), N-(4-(4-nitrophenoxy) Thieno[2,3-d]pyrimidin-2-yl)iso nicotinamide (8i), N-(4-(4-nitrophenoxy)thieno[2,3-d]pyrimidin-2-yl) thiophene-2-carboxamide (8j):

To a solution ofVarious Substituted Acids (7a-7e) (10.2 m.mol) in DMF (5v), HATU (10 m.mol), Hunig,s base (N,N-di isopropyl ethylamine, DIPEA) (20 m.mol), Stir at RT for 10 min under Nitrogen atmosphere, Then add 4-(4-(trifluoromethyl)phenoxy) thieno[2,3-d]pyrimidin-2-amine(6a), 4-(4-nitrophenoxy)Thieno[2,3-d]pyrimidin-2-amine (6b) (10.00 m.mol) at RT for 16 hrs, Then Reaction mixture was diluted with Ice Cold Water, Filtered the obtained Solid and Dried, Finally Purified by Flash Column Chromatography.

4-methyl-N-(4-(4-(trifluoromethyl)phenoxy) thieno[2,3-d]pyrimidin-2-yl)benzamide (8a): (Figure 6.5.1). This compound was obtained as off-white solid in 75% yield. M.p. 236-238OC.

IR (KBr, cm-1): 3243(N-H Stretching), 3110(Ar C-H), C-F (1365), 1695.20 (C=O Stretching).

1H NMR (DMSO-d6) (δ/ppm) δ ppm 2.35 (3H,S),7.15 (d, 1 H, J=7.1HZ), 7.10(1H, d, J=7.1HZ), 7.45(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 9.15(1H,bs), 7.91(2H,d, J=7.3 HZ), 7.35 (2H,d, J=7.3 HZ).

13C NMR (DMSO-d6) (δ/ppm): 23, 123.55, 125.15, 127.65,128.55, 145.35, 158.55, 163, 173.6.

13C NMR (100 MHz; CDCl3): δC 28, 105.73, 125.5, 128.89,130.55, 133.45,149, 158.8, 165.34.

ESI-MS m/z 430[M+1].

4-methoxy-N-(4-(4-(trifluoromethyl)phenoxy) thieno[2,3-d]pyrimidin-2- yl)benzamide(8b): (Figure 6.5.2). This compound was obtained as off-white solid in 80% yield. m.p. 247-249OC.

IR (KBr, cm-1): 2920(SP3C-H), 3243(N-H Stretching), 3110(Ar C-H), 1687.20 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.15 (d, 1H, J=7.1HZ), 7.10(1H, d, J=7.1HZ), 7.45(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 9.15(1H,bs), 7.91(2H,d, J=7.3 HZ), 7.35 (2H,d, J=7.3 HZ).

13C NMR (100 MHz; CDCl3): δC 58.88, 105.73, 125.5, 128.89, 130.55, 133.45,141,149, 158.8, 168.34.

ESI-MS m/z = 446.465 [M+H] +.

N-(4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d] pyrimidin-2-yl)pyrazine-2- carboxamide (8c): (Figure 6.5.3). This compound was obtained as off-yellow solid in 80% yield. m.p. 147-149OC.

IR (KBr, cm-1): 3234(N-H Stretching), 3105(Ar C-H), 1690.20 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.25 (d, 1H, J=7.1HZ), 6.95(1H, d, J=7.1HZ), 7.65(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 9.05(1H,bs), 9.91(1H,d, J=2.3 HZ), 9.15 (1H,d, J=7.3 HZ), 8.95(1H, d, J=7.3 HZ).

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55,158.8, 168.34, 172.65.

ESI-MS m/z = 418.465 [M+H] +.

N-(4-(4-(trifluoromethyl)phenoxy)thieno[2,3-d] pyrimidin-2-yl)isonicotinamide(8d): (Figure 6.5.4). This compound was obtained as off-yellow solid in 75% yield. m.p. 182-183OC.

IR (KBr, cm-1): 3264(N-H Stretching), 3115(Ar C-H), 1685.50 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.20 (d, 1H, J=7.1HZ), 6.98(1H, d, J=7.1HZ), 7.65(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 9.45(1H,bs), 7.91(2H,d, J=2.3 HZ), 8.95 (1H,d, J=7.3 HZ) .

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55, 158.8, 168.34, 172.65.

ESI-MS m/z = 417.465 [M+H] +.

N-(4-(4-(trifluoro methyl) phenoxy)thieno[2,3-d] pyrimidin-2-yl)thiophene-2-carboxamide (8e): (Figure 6.5.5). This compound was obtained as off-white solid in 70% yield. m.p. 153-156OC.

IR (KBr, cm-1): 3264(N-H Stretching), 3105(Ar C-H), 1690.50 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.20 (d, 1H, J=7.1HZ), 6.98(1H, d, J=7.1HZ), 7.45(2H,d, J=7.3HZ), 7.15(2H, d, J=7.3HZ), 9.35(1H,bs), 8.30(1H,d, J=6.8HZ), 8.15 (1H,d, J=6.8 HZ), 7.35(1H,t, J=6.8 HZ) .

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55, 158.8, 168.34, 172.65.

ESI-MS m/z = 422.465 [M+H] +.

4- methyl-N-(4-(4-nitrophenoxy) Thieno [2,3-d] pyrimidin-2-yl) benzamide (8f): (Figure 6.5.6). This compound was obtained as Pale-yellow solid in 75% yield. m.p. 223-225OC.

IR (KBr, cm-1): 3264(N-H Stretching), 3105(Ar C-H), N-O (1140 & 1325), 1690.50 (C=O Stretching).

1H NMR (DMSO-d6) (δ/ppm) δ ppm 2.35 (3H,S),7.15 (d, 1 H, J=7.1HZ), 7.10(1H, d, J=7.1HZ), 7.45(2H,d, J=7.3HZ), 8.15(2H, d,J=7.3HZ), 9.15(1H,bs), 7.91(2H,d, J=7.3 HZ), 7.35 (2H,d, J=7.3 HZ).

13C NMR (DMSO-d6) (δ/ppm): 23, 123.55, 125.15, 127.65,128.55, 145.35, 158.55, 163, 173.6.

ESI-MS m/z = 407.26 [M+H] +.

4-methoxy-N-(4-(4-nitrophenoxy)thieno[2,3-d] pyrimidin-2-yl)benzamide (8g): (Figure 6.5.7). This compound was obtained as yellow solid in 73% yield. m.p. 252-253OC.

IR (KBr, cm-1): 3260(N-H Stretching), 3105(Ar C-H), N-O [1148 & 1320], 1695 (C=O Stretching].

1H NMR (DMSO-d6] [δ/ppm] δ ppm 3.85 [3H,S],7.15 [d, 1 H, J=7.1HZ), 7.10(1H, d, J=7.1HZ), 7.4S(2H,d, J=7.3HZ), 8.1S(2H, d, J=7.3HZ), 9.1S(1H,bs), 7.90(2H,d, J=7.3 HZ), 7.2S (2H,d, J=7.3 HZ).

13C NMR (DMSO-d6) (δ/ppm): 58, 123.55, 125.15, 127.65,128.55, 145.35, 158.55, 163, 173.6.

ESI-MS m/z = 421.26 [M-H] +.

N-(4-(4-nitrophenoxy)thieno[2,3-d]pyrimidin-2-yl) pyrazine-2-carboxamide (8h): (Figure 6.5.8). This compound was obtained as pale-yellow solid in 80% yield. m.p. 245-247OC.

IR (KBr, cm-1): 3240(N-H Stretching), 3110(Ar C-H), N-O [1158 & 1340], 1685.20 [C=O Stretching].

1H NMR (400 MHz; CDCl3): δH 7.25 [d, 1H, J=7.1HZ], 6.9S(1H, d, J=7.1HZ), 7.55(2H,d, J=7.3HZ), 8.1S(2H, d, J=7.3HZ), 9.15(1H,bs), 9.91(1H,d, J=2.3 HZ), 9.1S (1H,d, J=7.3 HZ), 8.9S(1H,d, J=7.3 HZ).

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55,158.8, 168.34, 172.6S.

ESI-MS m/z = 395.465 [M+H] +.

N-(4-(4-nitrophenoxy) Thieno [2,3-d]pyrimidin-2-yl)iso nicotinamide (8i): (Figure 6.5.9). This compound was obtained as off-yellow solid in 78% yield. m.p. 232-233OC.

IR (KBr, cm-1): 3260(N-H Stretching], 3125(Ar C-H], N-O (1140 & 1350), 1680.50 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.20 (d, 1H, J=7.1HZ), 6.98(1H, d, J=7.1HZ], 7.65(2H,d, J=7.3HZ], 8.15(2H, d, J=7.3HZ], 9.25(1H,bs], 7.91(2H,d, J=7.3 HZ], 8.95 (2H,d, J=7.3 HZ] .

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55, 158.8, 168.34, 172.65.

ESI-MS m/z = 394.465 [M+H] +.

N-(4-(4-nitrophenoxy) Thieno [2,3-d]pyrimidin-2- yl)thiophene-2-carboxamide (8j): (Figure 6.5.10). This compound was obtained as off-yellow solid in 70% yield. m.p. 253-256OC.

IR (KBr, cm-1): 3264(N-H Stretching], 3105(Ar C-H], N-O (1150 & 1360), 1690.50 (C=O Stretching).

1H NMR (400 MHz; CDCl3): δH 7.20 (d, 1H, J=7.1HZ),6. 95(1H, d, J=7.1HZ], 7.45(2H,d, J=7.1HZ], 8.15(2H, d, J=7.1HZ], 9.38(1H,bs], 8.30(1H,d, J=6.8HZ], 8.15 (1H,d, J=6.8 HZ], 7.35(1H,t, J=6.8 HZ] .

13C NMR (100 MHz; CDCl3): δC 125.5, 128.89, 130.55,133.45,141,149, 155.55, 158.8, 168.34, 172.65.

ESI-MS m/z = 399.465 [M+H] +.

Biological Activity

Antibacterial studies

The newly prepared compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli (clinical isolate] bacterial strains by disc diffusion method [36,37]. Standard inoculums (1-2x107 c.f.u. /ml 0.5 McFarland standards) were introduced on to the surface of sterile agar plates, and a sterile glass spreader was used for even distribution of the inoculums. The disks measuring 6 mm in diameters were prepared from what man no. 1 filter paper and sterilized by dry heat at 140°C for 1 h. The sterile disks previously soaked in a known concentration of the test compounds were placed in nutrient agar medium. Solvent and growth controls were kept. Amoxicillin (30 μg) was used as positive control and the disk poured in DMSO was used as negative control and the test compounds were dissolved in DMSO at concentration of 100 and 50 μg/ml. The plates were inverted and incubated for 24 h at 37°C. The susceptibility was assessed on the basis of diameter of zone of inhibition against Gram-positive and Gram-negative strains of bacteria. Inhibition of zone of measured and compared with controls. The bacterial zone of inhibition values are given in (Table 1). The order of activity was 8j>8i>8h>8g>8d>8f>8b>8c>8e>8a (Table 1).

Antifungal Studies

The newly prepared compounds were screened for their antifungal activity against Candida albicans and Aspergillus flavus in DMSO by agar diffusion method [38]. Sabourauds agar media was prepared by dissolving peptone (1 g), D-glucose (4 g) and agar (2 g) in distilled water (100 ml) and adjusting pH 5.7. Normal saline was used to make suspension of corresponding species. Twenty milliliters of agar media was poured into each Petri dish. Excess of suspension was decanted and the plates were dried by placing in an incubator at 37°C for 1 h using an agar punch, wells were made and each well was labeled. A control was also prepared in triplicate and maintained at 37°C for 3-4 days. The fungal activity of each compound was compared with Flucanazole as a standard drug. Inhibition zone were measured and compared with the controls. The fungal zone of inhibition values are given in (Table 2).

Result and Discussions

Chemistry

The reaction sequences Employed for synthesis of title compounds are shown in (Scheme 1). In the present work, the starting Thieno [2,3-d]pyrimidine-2,4-diol(2) was prepared from methyl 2-aminothiophene-3-carboxylate (1) and Urea According to the reported procedure [39]. Next Step 2 is 2,4-dichloro Thieno[2,3-d]pyrimidine (3) was prepared by using POCl3 at reflux for 6 hrs According to the reported procedure [40]. The 2,4-dichlorothieno[2,3-d]pyrimidine (3) was Coupling with different Phenols (4 a-b) in Acetone at 70oC to get compounds 5(a-b) According to the reported procedure [41]. Which is further treatment with Aqueous Ammonia at 90OCAccording to the reported procedure [42]? which on further treatment with different Carboxylic acids (7a-e) to get target novel Thieno [2, 3- d] pyrimidine derivatives (8a-j) According to the reported procedure [42]. All compounds displayed IR, 1H and 13C NMR and mass spectra consistent with the assigned structures.1H NMR and IR spectrum of compounds (8 a-j) showed singlet at 2.3 ppm, 3.8 ppm are due to the aromatic methyl group protons and Aromatic methoxy group protons. The most characteristic IR absorption bands are at 3340 cm-1 (-NH), 760 cm-1 (C-Cl), 1150 & 1350 (N-O) cm-1 and 3320 &3250cm-1 (N-H Stretching in Amine group). The mass spectra of all the final derivatives showed comparable molecular ion peak with respect to molecular formula.

Anti-microbial studies

The newly synthesized compounds (8a-j) were screened for their in-vitro anti-bacterial activity against Bacillus subtilis, Staphylococcus aurous, Klebsiella pneumonia and Escherichia coli using Amoxicillin as standard by disc diffusion method (zone of inhibition. The test compounds were dissolved in dimethylsulfoxide (DMSO) at concentrations of 50 and 100 μg/ml. The antibacterial screening revealed that all the tested compounds showed good inhibition against various tested microbial strains compared to the standard drug. Along with he synthesized compounds 8j, 8i, 8h, 8g were found to be more active against tested bacterial strains as compared to the standard.

Conclusion

The research study reports the successful synthesis and anti-microbial activity of novel Thieno [2,3-d] Pyrimidine as a core unit . The anti-microbial activity study revealed that all the tested compounds showed good antibacterial and antifungal activities against pathogenic strains. Compounds 8j, 8i, 8h and 8g exhibited more potent anti-microbial activity of all tested pathogenic strains. Few of synthesized compounds might be useful as antimicrobial agents in future. These novel Thieno [2,3-d] Pyrimidine derivatives have proved to be promising candidates for further efficacy evaluation. On the basis of their activity, these derivatives were identified as viable leads for further studies.

Acknowledgment

Authors are thankful to Prof. K. Sudhakar Babu, Registrar, Sri Krishnadevaraya University for Encouraging & facilities of IR Spectra, 1H NMR & 13C NMR for characterization of Novel Synthesized compounds.

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Some Functions of Industrial Magnesium Oxide

  For the functions of industrial magnesium oxide, as a professional magnesium oxide manufacturer and supplier, Meishen Technology introduces something about it here. Therefore, looking at the follow explanations, you will know more about the industrial grade magnesium oxide:

  1. The special magnesium oxide for adhesive: when used in the aspect of high end adhesive, it has a lot of advantages of high iodine absorption value, good dispersibility, low iron content and so on. Mixing with resin, it can effectively prevent the hierarchy and sediment of glue soluting, and increase heat tolerance and resting stability of glue soluting.

  2. Feed grade magnesium oxide. It is used in the annexing agent of animal feeding stuff, it can prevent the nervous system disease from magnesium deficiency.

  3. Special magnesium oxide for cable rubber. It is usually used in the industries of cabtyre cable, mine cable, marine cable and so on. Therefore, the cable will be improved antiseptic property, acid resistance, high temperature resistance and others. In the severe conditions, the working stability is also improved a lot.

  4. Magnesium oxide for brake block. It can be applied in the wear-resistant material and heat resisting fire suppressor to increase the stability of materials.

  5. Reactive magnesium oxide. The reactive magnesium oxide often used for surgical andhygienic rubber goods, adhesive and other industries.

  6. Special magnesium oxide for concentrated nitric acid. it is applied to purificate and produce concentrated nitric acid. It mainly plays a role of water absorption in the production process.  

  7. Magnesium oxide for other special industries. For example, AR grade magnesium oxide.

  8. Pharmaceutical grade magnesium oxide. It is mainly applied as medical intermediate and stomach medicine annexing agent. What’s more, it can effectively control hydrochloric acid in gastric juice, gastro-duodenal ulcer and so on.

  9. High pure magnesium oxide. It is mianly used in heat resisting work. For example, the lining and exit of steel furnace in iron and steel industry.

  10. Light magnesium oxide. The light magnesium oxide is mainly used in rubber, electronic ceramics, adhesive and other industries. The application field is very extensive.

  11. Magnesium oxide hydroxide. The magnesium hydroxide is used as fire retardant. Generally speaking, it usually used in antiseptic fire-proof, board fireproofing, flame-retardant cable and other industries.

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Innovative and Superior Chemistry: AR Grade Distilled Chlorosulfonic Acid by Maruti Fine Chemicals

In the field of chemical manufacturing, Maruti Fine Chemicals is considered a pioneer in innovation and quality. The company's latest breakthrough development of AR Grade Distilled Chlorosulfonic Acid will redefine industry standards and enhance the capabilities of researchers and industry alike.

Chlorosulfonic acid is an important reagent in a variety of chemical processes, and at Multi Fine Chemicals it undergoes a careful distillation process to achieve the highest level of purity. It is called analytical reagent (AR). This means researchers and professionals can rely on unparalleled quality products for their most critical applications.

The benefits of AR Grade Distilled Chlorosulfonic Acid Maruti Fine Chemical AR Grade are numerous. The increased purity significantly reduces impurities and contaminants, minimizing the risk of unwanted side reactions and ensuring experimental reproducibility. This high-quality product is intended to become an essential tool in laboratories, research facilities, and production facilities.

 Maruti Fine Chemicals has always been committed to sustainability and this commitment extends to our AR Grade Distilled Chlorosulfonic Acid. The production process is designed to be environmentally friendly and is subject to strict quality and safety standards. The company's commitment to responsible manufacturing practices ensures that customers not only receive first-class products, but also contribute to a greener and more sustainable future.

 customers can trust Multi Fine Chemical not only for product quality but also for comprehensive customer support. The company's team of experts is always available to provide technical support to help customers maximize the potential of his AR grade distilled chlorosulfonic acid in their applications.In conclusion, Maruti Fine Chemicals' AR Grade Distilled Chlorosulfonic Acid is revolutionizing the chemical industry. Its exceptional purity, combined with the company's commitment to sustainability and customer care, sets a new standard of excellence. This cutting-edge product from Maruti Fine Chemicals enables researchers, scientists and industry professionals to take their research to a new level.

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Unveiling Excellence in Chemical Solutions: AR Grade Hydrochloric Acid

Introduction: In the realm of chemical industries, the quality and purity of acids play a pivotal role in ensuring precise and reliable outcomes. Maruti Fine Chemical emerges as a beacon of excellence, offering top-notch AR Grade Hydrochloric Acid and LR Grade Sulphuric Acid. In this blog, we delve into the unique characteristics of these chemical solutions and shed light on how Maruti Fine Chemical is revolutionizing the industry.

AR Grade Hydrochloric Acid: Hydrochloric Acid, a powerful and versatile chemical, finds applications across various industries, from pharmaceuticals to metallurgy. Maruti Fine Chemical's AR Grade Hydrochloric Acid stands out for its exceptional purity, making it suitable for critical laboratory applications and analytical techniques.

Key features of AR Grade Hydrochloric Acid:

High Purity: Maruti Fine Chemical ensures that their AR Grade Hydrochloric Acid meets stringent purity standards, minimizing impurities that could affect experimental outcomes.

Precise Concentration: The acid is formulated with precise concentrations, allowing for accurate and reproducible results in various laboratory processes.

Stringent Quality Control: Maruti Fine Chemical employs rigorous quality control measures to guarantee the consistency and reliability of their AR Grade Hydrochloric Acid, providing researchers and scientists with peace of mind.

LR Grade Sulphuric Acid: Sulphuric Acid, an essential component in numerous industrial processes, demands a high level of purity and precision. Maruti Fine Chemical's LR Grade Sulphuric Acid is designed to meet these exacting standards, ensuring optimal performance in various applications.

Key features of LR Grade Sulphuric Acid

Impurity-Free Composition: Maruti Fine Chemical employs advanced manufacturing processes to create LR Grade Sulphuric Acid with minimal impurities, enhancing its suitability for laboratory and industrial uses.

Consistent Quality: The acid is manufactured under strict quality control measures, ensuring a consistent and reliable product that meets the needs of diverse industries.

Versatile Applications: LR Grade Sulphuric Acid by Maruti Fine Chemical finds applications in laboratories, educational institutions, and industries requiring a reliable and pure form of this essential acid.

Promoting Maruti Fine Chemical: Maruti Fine Chemical's commitment to excellence extends beyond the quality of their products. The company's customer-centric approach, timely delivery, and competitive pricing make them a preferred choice in the chemical industry.

Why Choose Maruti Fine Chemical?

Quality Assurance: Maruti Fine Chemical prioritizes quality, ensuring that their products consistently meet or exceed industry standards.

Customer Satisfaction: With a focus on customer needs, Maruti Fine Chemical strives to provide personalized service, understanding and addressing the unique requirements of each client.

Innovation and Sustainability: Maruti Fine Chemical is dedicated to staying at the forefront of industry trends, embracing innovation, and promoting sustainable practices in chemical manufacturing.

Conclusion: In the world of chemical solutions, Maruti Fine Chemical sets itself apart through its unwavering commitment to quality, precision, and customer satisfaction. The AR Grade Hydrochloric Acid and LR Grade Sulphuric Acid offered by Maruti Fine Chemical exemplify the company's dedication to providing reliable and high-quality chemical solutions. As a partner in progress, Maruti Fine Chemical continues to shape the future of the chemical industry with its innovative approaches and steadfast commitment to excellence.

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Unveiling Excellence: AR Grade Distilled Chlorosulfonic Acid

In the realm of chemical manufacturing, precision and purity are paramount. Researchers, laboratories, and industries alike seek substances that meet the highest standards of quality. Maruti Fine Chemicals has emerged as a leading player in this domain, particularly with its exceptional offering — AR Grade Distilled Chlorosulfonic Acid. In this blog, we delve into the significance, properties, and applications of this chemical marvel that has become synonymous with excellence.

Understanding AR Grade Distilled Chlorosulfonic Acid:

AR Grade Distilled Chlorosulfonic Acid stands as a testament to Maruti Fine Chemicals’ commitment to delivering top-notch products. The term “AR” refers to Analytical Reagent, denoting a level of purity suitable for analytical and laboratory use. Distilled Chlorosulfonic Acid, a derivative of sulfuric acid, is subjected to rigorous purification processes, ensuring a product that meets the stringent demands of various scientific applications.

Properties:

Purity: The hallmark of AR Grade Distilled Chlorosulfonic Acid is its unparalleled purity. Maruti Fine Chemicals employs advanced distillation techniques to eliminate impurities, resulting in a product that exceeds analytical standards.

Stability: The chemical stability of AR Grade Distilled Chlorosulfonic Acid is a key attribute, making it a reliable choice for laboratories and industries where consistency is paramount. The controlled manufacturing process ensures a stable product with minimal batch-to-batch variation.

Solubility: These chemical exhibits excellent solubility in various solvents, enhancing its versatility in different applications. Researchers and scientists appreciate its ease of use, allowing for seamless integration into diverse experimental setups.

Applications and Uses:

Laboratory Analysis: AR Grade Distilled Chlorosulfonic Acid finds extensive use in laboratories for analytical purposes. Its high purity makes it an ideal reagent for precise and accurate testing, particularly in the fields of chemistry and biochemistry.

Chemical Synthesis: In the realm of chemical synthesis, the stringent demands for purity and stability are met by AR Grade Distilled Chlorosulfonic Acid. It serves as a crucial component in the synthesis of various chemicals, pharmaceuticals, and specialty materials.

Industrial Processes: Industries relying on meticulous chemical processes benefit from the reliability of Maruti Fine Chemicals’ AR Grade Distilled Chlorosulfonic Acid. It plays a pivotal role in the production of polymers, dyes, and other essential industrial materials.

Benefits of Choosing AR Grade Distilled Chlorosulfonic Acid: Discover the enhanced performance and increased reliability that come with opting for AR Grade Distilled Chlorosulfonic Acid, making it a preferred choice in the market.

Safety Considerations: This section provides essential guidelines for safe handling and storage of AR Grade Distilled Chlorosulfonic Acid, emphasizing the importance of precautionary measures.

Customer Testimonials: Real-world experiences and positive feedback from customers highlight the practical benefits of using AR Grade Distilled Chlorosulfonic Acid.

Comparisons with Other Grades: Understand the distinctions between distilled and non-distilled forms, along with key differentiators that set AR Grade apart in terms of quality.

Future Trends and Innovations: Explore the ongoing research and development efforts, as well as emerging applications that indicate a promising future for AR Grade Distilled Chlorosulfonic Acid.

Conclusion: In conclusion, AR Grade Distilled Chlorosulfonic Acid from Maruti Fine Chemicals emerges as a versatile and reliable solution. With its exceptional quality, it opens new possibilities across various industries.

Quality Assurance:

Maruti Fine Chemicals’ commitment to quality extends beyond the manufacturing process. Rigorous quality control measures are implemented to ensure that each batch of AR Grade Distilled Chlorosulfonic Acid meets and exceeds industry standards. This dedication to quality has positioned Maruti Fine Chemicals as a trusted supplier in the chemical manufacturing landscape.

Conclusion:

AR Grade Distilled Chlorosulfonic Acid by Maruti Fine Chemicals stands as a beacon of excellence in the realm of chemical manufacturing. Its unmatched purity, stability, and diverse applications make it a go-to choice for laboratories, research institutions, and industries worldwide. As technology advances and scientific endeavors become more intricate, the need for high-quality reagents like , AR Grade Distilled Chlorosulfonic Acid becomes increasingly apparent. In the pursuit of precision and reliability, Maruti Fine Chemicals continues to shine, providing a catalyst for innovation in the scientific.

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Your Trusted Source for AR Grade Hydrochloric Acid

Discover the excellence of AR Grade Hydrochloric Acid by Maruti Fine Chemicals – your go-to for high-quality chemical solutions!

 Why Choose Maruti Fine Chemicals?

Purity Assured: Our AR Grade Hydrochloric Acid is of the highest purity, meeting industry standards for accuracy in lab applications.

Reliable Source: Count on Maruti Fine Chemicals for consistency in quality – a name trusted by laboratories and industries alike.

Expertise Matters: Backed by years of experience, we understand the critical importance of precise chemical compositions.

Order Now and Experience the Maruti Difference! Contact us to secure your supply of AR Grade Hydrochloric Acid – unlocking the potential for accurate and reliable results in your experiments and processes.

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AR Grade Distilled Chlorosulfonic Acid by Maruti Fine Chemicals

Dive into excellence with Maruti Fine Chemicals' AR Grade Distilled Chlorosulfonic Acid! Our commitment to quality ensures a product of the highest standards. Meticulously distilled, this chemical marvel stands out in purity and precision.

Maruti Fine Chemicals takes pride in delivering a product that meets the demanding criteria of Analytical Reagent (AR) Grade. This AR Grade Distilled Chlorosulfonic Acidis crafted with precision to serve diverse applications in laboratories and industries.

Our stringent quality control measures guarantee a product that adheres to the most rigorous standards, ensuring reliability and accuracy in your experiments and processes. Trust Maruti Fine Chemicals for a seamless experience with AR Grade Distilled Chlorosulfonic Acid, where purity meets performance. Choose excellence; choose Maruti Fine Chemicals for your chemical needs. Elevate your work with the finest in the industry

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Laboratory Chemicals: The Ultimate Guide to Choosing and Using Them

 Laboratory chemicals play a vital role in scientific research, medical advancements, and industrial processes. Whether you’re a seasoned scientist or a student stepping into the lab for the first time, understanding laboratory chemicals is essential for accuracy, safety, and success in experiments.

In this blog, we’ll dive into the world of laboratory chemicals, their types, usage, and how to source them effectively. Read on to discover how to make informed decisions and ensure optimal results in your laboratory work.

What Are Laboratory Chemicals?

Laboratory chemicals are substances used in scientific and medical experiments, tests, and manufacturing processes. These chemicals are characterized by their high purity levels, ensuring that they do not interfere with experimental results. From acids and bases to reagents and solvents, laboratory chemicals come in various forms and compositions to suit diverse applications.

Types of Laboratory Chemicals

To select the right laboratory chemicals, it’s important to understand their categories:

1. Analytical Reagents (AR)

Analytical reagents are of the highest purity and are used for analytical testing. These include chemicals like sodium chloride, hydrochloric acid, and ethanol.

2. General Reagents (GR)

General reagents are commonly used for non-critical applications. They may have slightly lower purity but are suitable for teaching labs and routine experiments.

3. Specialized Chemicals

Certain applications require unique laboratory chemicals like biochemicals, organic solvents, and isotopes for highly specific functions.

4. Industrial Grade Chemicals

Industrial-grade laboratory chemicals are used in manufacturing and large-scale processes where purity may not be as crucial as cost-effectiveness.

How to Choose Laboratory Chemicals

Selecting the right laboratory chemicals is crucial for ensuring reliable outcomes. Here are some tips:

Identify Your Requirements

Define the purpose of the experiment to determine the type and grade of laboratory chemicals needed.

Check Purity Levels

Look for chemicals with certification labels indicating their grade (AR, GR, etc.).

Read Safety Data Sheets (SDS)

Understand the chemical properties, hazards, and handling precautions by referring to the Safety Data Sheets provided by manufacturers.

Buy from Reputable Suppliers

Trusted suppliers ensure high-quality laboratory chemicals with consistent performance.

Safety Tips for Handling Laboratory Chemicals

Working with laboratory chemicals requires strict adherence to safety practices to prevent accidents and health risks. Here are key safety tips:

Wear Personal Protective Equipment (PPE): Always use gloves, goggles, and lab coats.

Follow Proper Storage Guidelines: Store laboratory chemicals in appropriate containers and conditions as per their requirements.

Ensure Ventilation: Conduct experiments in a well-ventilated area or under a fume hood.

Label All Containers: Clearly mark chemicals with their names, concentrations, and hazard levels.

Dispose of Chemicals Responsibly: Follow local regulations for the disposal of chemical waste.

Where to Buy Laboratory Chemicals

Finding reliable sources for laboratory chemicals ensures quality and safety. Look for suppliers that provide:

High-purity products verified by testing.

Certifications like ISO, ensuring compliance with international standards.

Prompt customer service for addressing concerns or queries.

Online marketplaces and specialized chemical suppliers are excellent platforms to source laboratory chemicals conveniently. Verify reviews and ratings to choose trusted providers.

Conclusion

Laboratory chemicals are indispensable in driving scientific innovations and industrial progress. By understanding their types, sourcing them wisely, and adhering to safety protocols, you can achieve accurate and reliable results. Whether you’re conducting basic experiments or advanced research, the proper use of laboratory chemicals is the cornerstone of success.

Explore trusted suppliers to access premium laboratory chemicals and empower your experiments today. The world of discovery awaits!

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Enhance Your Laboratory Efficiency with Hydrochloric Acid LR Grade by  Maruti Fine Chemicals

Both Hydrochloric Acid LR grade and Hydrochloric Acid AR grade from Maruti Fine Chemicals are produced to high standards, ensuring you receive a product that meets your specific requirements. Our commitment to quality and customer satisfaction makes us a trusted source for all your hydrochloric acid needs.

Whether you need Hydrochloric Acid for routine lab work or for more precise analytical purposes, Maruti Fine Chemicals provides reliable solutions tailored to your needs.

Visit - https://www.indiamart.com/proddetail/ar-grade-hydrochloric-acid-11138655773.html

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Understanding Hydrochloric Acid LR Grade: Properties and Applications

Hydrochloric acid (HCl) is a crucial chemical compound with various industrial applications. At Maruti Fine Chemicals, we provide both LR (Laboratory Reagent) grade and AR (Analytical Reagent) grade hydrochloric acid to meet diverse needs. In this blog, we delve into the differences between LR and AR grades of hydrochloric acid, their applications, and frequently asked questions.

What is Hydrochloric Acid?

Hydrochloric acid, often referred to as muriatic acid, is a clear, colorless, highly corrosive solution of hydrogen chloride (HCl) in water. It’s a strong mineral acid widely used in industrial processes, chemical synthesis, and laboratory applications.

Hydrochloric Acid LR Grade

Hydrochloric Acid AR Grade

Hydrochloric acid ar grade, on the other hand, is of higher purity compared to LR grade. It adheres to stricter quality standards and is often utilized in analytical chemistry for precise and accurate results. AR grade is preferred for critical analytical procedures and instrumental analysis.

Applications LR Grade:

Commonly used in educational institutions for basic experiments. Suitable for general qualitative analysis. Used in various industrial processes where high purity is not essential.

AR Grade:

Ideal for precise quantitative analysis in laboratories. Essential for analytical techniques like titrations, chromatography, and spectroscopy. Preferred for research and quality control purposes.

FAQs

Q:1 What are the main differences between LR and AR grade hydrochloric acid?

LR grade hydrochloric acid meets general laboratory standards and is suitable for basic analytical procedures, whereas AR grade offers higher purity and is utilized for more precise and accurate analytical work.

Q:2 Can LR grade hydrochloric acid be used interchangeably with AR grade?

It depends on the specific application. While LR grade may suffice for certain experiments and industrial processes, AR grade is recommended for critical analytical procedures where precise results are paramount.

Q:3 How should hydrochloric acid be handled safely?

Q:4 Is hydrochloric acid environmentally friendly?

Hydrochloric acid is a strong acid and can be harmful to the environment if not handled properly. Proper disposal procedures should be followed to minimize environmental impact.

Q:5 Can hydrochloric acid be used in food preparation?

No, hydrochloric acid is not suitable for food preparation purposes due to its corrosive nature. It should only be used in industrial and laboratory settings under controlled conditions.

Conclusion:

In conclusion, both and hydrochloric acid ar grade and lr grade play vital roles in laboratory and industrial applications. Choosing the appropriate grade depends on the specific requirements of the analytical procedure or industrial process. At Maruti Fine Chemicals, we ensure the highest quality standards in our hydrochloric acid products to meet the diverse needs of our customers.

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Exploring the Benefits of LR Grade Sulphuric Acid - Maruti Fine Chemicals

LR Grade Sulphuric Acid is a high-purity form of sulfuric acid that is suitable for laboratory and analytical use. Here are some potential benefits and applications:

Analytical Chemistry: LR Grade Sulphuric Acid is commonly used in laboratories for various analytical purposes, including titrations and sample preparations. Its high purity ensures accurate and reliable results in analytical chemistry.

Laboratory Reagents: It serves as a critical reagent in various laboratory processes and experiments, particularly in chemical analysis and research.

pH Adjustments: Sulphuric acid is often used to adjust the pH of solutions in laboratories and industrial processes. It is a strong acid and can be used to make acidic solutions.

Catalyst: Sulphuric acid can act as a catalyst in certain chemical reactions, facilitating the reaction process without being consumed in the overall reaction.

Dehydrating Agent: Sulphuric acid is a powerful dehydrating agent and is used in processes where water removal is essential, such as in the synthesis of certain chemicals.

Industrial Processes: Beyond laboratory use, sulphuric acid finds extensive applications in various industrial processes, including the production of fertilizers, detergents, and chemicals.

It's important to note that handling sulphuric acid, even in its laboratory-grade form, requires strict adherence to safety guidelines. Users should be aware of the potential hazards and take necessary precautions, such as wearing protective gear and working in a well-ventilated area. Maruti Fine chemicals is best company for buying chemicals .

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Unveiling the Superiority of AR Grade Hydrochloric Acid

Maruti Fine Chemicals takes pride in its commitment to providing high-quality chemicals for various industries. In this content piece, we'll delve into the fascinating world of chemistry, focusing on the combination of AR Grade Hydrochloric Acid and LR Grade Sulphuric Acid offered by Maruti Fine Chemicals.

AR Grade Hydrochloric Acid: AR, or Analytical Reagent, Grade Hydrochloric Acid is a meticulously purified and highly concentrated form of hydrochloric acid. This grade is specifically designed for analytical and laboratory applications where precision and purity are of utmost importance. Maruti Fine Chemicals ensures that their AR Grade Hydrochloric Acid meets stringent quality standards, making it a reliable choice for various scientific processes.

LR Grade Sulphuric Acid: LR, or Laboratory Reagent, Grade Sulphuric Acid is another essential chemical provided by Maruti Fine Chemicals. Sulphuric acid is a strong mineral acid with versatile applications in industries such as manufacturing, laboratory research, and chemical synthesis. The LR grade guarantees a high level of purity suitable for precise analytical work and experimentation.

The Synergy of AR Grade Hydrochloric Acid and LR Grade Sulphuric Acid: Maruti Fine Chemicals recognizes the significance of combining AR Grade Hydrochloric Acid and LR Grade Sulphuric Acid for certain chemical processes. This combination often serves as a catalyst or reactant in various reactions, leading to the formation of new compounds or facilitating specific chemical transformations.

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10 Ways to Maximize the Benefits of Fuming Nitric Acid

In the vast landscape of chemicals, Fuming Nitric Acid and Hydrochloric Acid AR Grade stand out as key players, each serving unique purposes in various industries. Maruti Fine Chemicals, a reputable supplier, takes center stage in ensuring the quality and reliability of these essential substances.

Let’s begin with a closer look at Fuming Nitric Acid. This potent compound is aptly named for its distinct fumes, owing to the presence of nitrogen dioxide. Maruti Fine Chemicals provides a superior quality Fuming Nitric Acid known for its strong oxidizing properties. This chemical powerhouse finds applications in explosive synthesis, specialty chemical, buy nitric acid online manufacturing, and even in the meticulous processes of metal etching and cleaning.

Now, let’s shine a spotlight on the backbone of these chemicals — Maruti Fine Chemicals. As a trusted supplier, Maruti Fine Chemicals places a strong emphasis on quality assurance. Their products undergo stringent quality control measures, ensuring compliance with industry standards. This commitment to excellence makes Maruti Fine Chemicals a reliable source for Fuming Nitric Acid and Hydrochloric Acid AR Grade.

Customer satisfaction is a cornerstone for Maruti Fine Chemicals. Timely deliveries, responsive customer support, and the ability to provide customized solutions for specific requirements make them a preferred choice in the chemical supply industry.

Conclusion:

In conclusion, when it comes to Fuming Nitric Acid and Hydrochloric Acid AR Grade, Maruti Fine Chemicals stands out as a beacon of quality and reliability. Whether you’re involved in explosive synthesis, laboratory analysis, or industrial processes, Maruti Fine Chemicals has you covered with top-notch products and exceptional service.

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The Best Places to Buy Nitric Acid Online

In the fascinating world of chemistry, acids play a crucial role in various industrial processes and laboratory experiments. Nitric acid, hydrochloric acid, and sulphuric acid are three essential chemicals with diverse applications. Today, we’ll explore the convenience of buy nitric acid online, specifically from Maruti Fine Chemicals, a reputable supplier known for its quality and reliability.

Nitric Acid — Unleashing a Powerful Oxidizer:

Hydrochloric Acid AR Grade — A Versatile Laboratory Reagent:

Hydrochloric acid, commonly known as muriatic acid, holds a special place in laboratories as an analytical reagent (AR grade). Its versatility makes it indispensable for various applications, including titrations, pH adjustments, and metal cleaning processes. Maruti Fine Chemicals recognizes the importance of providing high-quality hydrochloric acid for laboratory use. Acquiring hydrochloric acid online offers the convenience of doorstep delivery and the assurance of quality. Maruti Fine Chemicals ensures that their Hydrochloric acid ar grade meets strict purity standards, making it suitable for precise analytical work. The secure online platform simplifies the buying process, allowing researchers, scientists, and educators to focus on their work without compromising on the quality of their reagents.

Sulphuric Acid LR Grade — A Catalyst in Chemical Laboratories:

Maruti Fine Chemicals — Your Reliable Partner in Chemical Procurement:

Maruti Fine Chemicals stands as a beacon of reliability in the chemical supply industry. With a commitment to quality, safety, and customer satisfaction, they have become a preferred choice for individuals and industries seeking nitric acid, Hydrochloric acid ar grade, and sulphuric acid LR grade. The user-friendly online platform of Maruti Fine Chemicals simplifies the buying process, ensuring a seamless experience for customers. The company’s dedication to quality control and adherence to safety standards make them a trusted partner for chemical procurement. Whether you’re a researcher, scientist, or industry professional, Maruti Fine Chemicals is poised to meet your specific chemical needs.

Conclusion:

In conclusion, the convenience of buy nitric acid online, hydrochloric acid AR grade, and sulphuric acid LR grade from Maruti Fine Chemicals opens new doors for researchers, scientists, and industry professionals. By prioritizing quality, safety, and customer satisfaction, Maruti Fine Chemicals establishes itself as a reliable partner in the chemical supply chain. Embrace the future of chemical procurement with Maruti Fine Chemicals, and unlock the potential of these essential acids in your laboratory or industrial processes.