#Hasenkrug

[sarcasticcynic]

“U.S. President Donald Trump’s administration has ordered scientists employed by the U.S. National Institutes of Health (NIH) to stop acquiring new human fetal tissue for experiments ... The suspension, imposed this past September without a public announcement, came as the government launched a review of all fetal tissue research funded by the federal government. ... The order expands the scope of the Trump administration’s interventions into federally funded research that uses human fetal tissue from elective abortions, which is legal but fiercely opposed by antiabortion groups.”

Why would the Trump administration do such a thing?

“Congressional Republicans have tried to ban all fetal tissue research for years to appease the religious right. ... The ban has long been a goal of the anti-abortion industry and has been part of the most recent attacks on Planned Parenthood. The group was falsely accused of selling aborted fetuses earlier this year.”

Ah. As usual, Trump is happy to order via executive fiat what Congress refuses to enact into law. But surely saying this “shuts down HIV cure research” is an exaggeration, no?

“‘We were all poised to go and then the bombshell was dropped,’ says HIV researcher Warner Greene, director of the Gladstone Center for HIV Cure Research in San Francisco, California, who was collaborating with an NIH laboratory that received the order. Researcher Kim Hasenkrug had prepared humanized mice for a trial of an antibody that the researchers believed���based on promising lab dish studies—might prevent HIV from establishing reservoirs in the human body. ... On 11 September, Hasenkrug informed Greene and Thomas Packard, a postdoctoral student of Greene’s, that he had obtained needed reagents and the mice were ready. Packard responded that they were excited at the prospect of getting the study started, and would immediately send Hasenkrug a batch of the antibodies. ‘I’ll not be able to get [the antibodies] on the 3 PM FedEx today, but I’ll ship [the antibodies] to you tomorrow, so you should have it on Thursday,’ Packard wrote in an email. On 28 September, however, Greene received a message from Hasenkrug that left him stunned. The email, which bore the subject line ‘HHS directive,’ read in part: ‘[HHS] has directed me to discontinue procuring fetal tissue from ABR, the only source for us. I think that they are the only provider of fetal tissue for scientists in the nation who don’t have direct access to aborted fetal tissue. This effectively stops all of our research to discover a cure for HIV.’ Hasenkrug had not yet launched the experiment, Greene says, and his supplies of existing mice were too small to conduct the repeated experiments required to reach convincing scientific conclusions.”

Guess not. Well, maybe it’s only temporary.

“The NIH’s actions have already slowed down progress on a cure. ‘If we were given the green light right now, it would probably take us a year to get back in the position we were in when the ban was put in place.’”

Hmm. Sucks for all those gay people, amiright? Good thing it won’t impact religious conservatives who devoutly support Trump and the GOP!

“A third laboratory at the National Institutes of Health (NIH) is also affected by the agency’s temporary ban on acquiring new human fetal tissue ... The third laboratory is at the National Cancer Institute (NCI), which is pursuing a ‘project on cancer immunotherapy, which will need tissue by January 31.’”

Oops.

[organiclifestylemagazine]

Trump’s Ban On the Use of Fetal Tissue Delays Coronavirus Vaccine Research

A recent report by Washington Post’s Amy Goldstein, states that immunologist Kim Hasenkrug wants to test potential treatments for Covid-19 in mice using “humanized lungs.” Officials at the Department of Health and Human Services are not allowing the research because using donated fetal tissue from abortions was banned last year by the Trump administration.

Government scientists will be barred from conducting research using donated fetal tissue the Trump administration announced on Wednesday, dealing a major blow to scientists who say it is an irreplaceable part of ongoing scientific research.

Trump Administration Bans Government Scientists From Using Fetal Tissue – Jun 6, 2019

Fetal tissue from abortions is used to create mice with human tissue suitable for medical testing. The research Kim Hasenkrug proposed reportedly aims to use mice with implanted fetal lung tissue, then infecting the mice with coronavirus strains similar to CoVID-19, and then testing for successful treatments for CoVID-19.

Recommended: How to Eliminate IBS, IBD, Leaky Gut 

Humanized mice have been key to developing several important medical treatments for diseases like the Zika virus or HIV/AIDS, which was Hasenkrug’s previous research focus. The calculation is simple. You can’t test certain treatments without humanized mice, and you can’t get humanized mice without fetal tissue.

… The calculation is simple. You can’t test certain treatments without humanized mice, and you can’t get humanized mice without fetal tissue.

Coronavirus treatment research is being held up by Trump’s ban on the use of fetal tissue

The Washington Post reported that Kim Hasenkrug at the NIH Rocky Mountain Laboratories in Montana has been appealing for “nearly a month” to get approval for the experiments using fetal tissue.

Regarding the proposal, a spokesperson for the Department of Health and Human Services told CNA “no decision has been made.”

Related: How Plumbing Eradicated Disease

Trump’s Ban On the Use of Fetal Tissue Delays Coronavirus Vaccine Research was originally published on Organic Lifestyle Magazine

[fumpkins]

United States extends fetal tissue contract and revives one experiment | Science

Researchers at the federal Rocky Mountain Laboratories in Hamilton, Montana, ​have actually rebooted an HIV research study that was disrupted by an order to stop getting human fetal tissue.

National Institute of Allergic Reaction and Contagious Diseases/National Institutes of Health (CC BY-NC)

The U.S. federal government’s leading medical research study firm is silently extending and restoring research study that counts on human fetal tissue, even as President Donald Trump’s administration contemplates the future of the questionable operate in a significant evaluation.

Early this month, the National Institutes of Health (NIH) in Bethesda, Maryland, informed scientists it plans to extend a crucial firm contract that funds work utilizing human fetal tissue to establish mice utilized to check drugs versus HIV. Without NIH action, the $2 million annual contract in between its National Institute of Allergic Reaction and Contagious Illness (NIAID) and researchers at the University of California, San Francisco (UCSF), will end on 5 March.

Typically, the contract, which has actually remained in location for many years, is restored each December. However in December 2018, NIH extended it for simply 90 days. Authorities stated the much shorter renewal was an action to an ongoing review of federally moneyed fetal tissue research study by the U.S. Department of Health and Person Provider (HHS), and that no decision on the contract’s fate would be made till that evaluation was total. The most recent extension would keep the contract alive for an extra 90 days, through 5 June, according to a 7 February letter from NIH to UCSF gotten under the Flexibility of Details Act.

“We are working with NIH to extend the contract. We remain confident that the critically important work of the lab will be continued,” UCSF stated in a declaration.

NIH has actually likewise restored an HIV experiment that was derailed last fall, days after the Trump administration launched a review of all U.S. federal government–financed research study that utilizes fetal tissue contributed by females after optional abortions. The research study was being performed at NIAID’s Rocky Mountain Laboratories (RML) in Hamilton, Montana, where researchers get fetal tissue that they utilize to develop mice with humanlike body immune systems. Laboratory meal research studies had actually led them to think that an antibody may avoid HIV from developing tanks in the body. They were preparing to utilize the humanized mice in a trial checking the antibody when they got an order from HHS directing them to stop getting fetal tissue from Advanced Bioscience Resources, a business in Alameda, California. (Days previously, HHS had canceled a Food and Drug Administration contract with the business.)

The HHS order “effectively stops all of our research to discover a cure for HIV,” Kim Hasenkrug, lead researcher at RML, composed at the time to a partner, Warner Greene of the Gladstone Center for HIV Remedy Research Study in San Francisco.

Notified to the experiment’s hindering, Lawrence Tabak, deputy director of NIH, said in December 2018 that the blockage had actually arised from a miscommunication. “We’re now figuring out ways to address that,” Tabak stated at that time.

Ever Since, NIH has actually discovered another fetal tissue provider for the researchers at RML. This permitted the antibody experiment to release last month, Greene informed ScienceExpert the other day, with 18 mice getting the antibody and 18 control mice not getting it. Another accomplice of 22 cured mice and 22 controls was introduced in early February, and the RML detectives anticipate in March or April to get extra mice that will enable more friends to be checked, Greene stated.

“Our studies are back on track, thanks to the efforts of the NIH,” states Greene, whose laboratory did early experiments that exposed the antibody’s prospective function, and then offered the antibody for the research studies. “I just want to emphasize how gratifying it has been to work positively with the NIH on this to solve this problem.” Greene decreased to state what provider is offering fetal tissue for the experiments.

Renate Myles, an NIH representative, composed in an e-mail today: “The HHS audit remains in no chance planned to hinder research study. The hold-up in Hasenkrug’s research study was unintended and the concern was remediated when we were made from knowledgeable about the requirement for brand-new [fetal tissue] procurement.”

However research study supporters applauded the NIH for acting. “It’s very important that NIH is finding ways to continue this critical research. The development of these fetal tissue mice currently is the state of the art” in crucial locations of HIV research study, states Sally Temple, clinical director of the Neural Stem Cell Institute in Rensselaer, New York City, and a previous president of the International Society for Stem Cell Research Study.

NIH approximates it will invest $95 million on tasks including human fetal tissue this year, below an approximated $103 million in 2018.

The Susan B. Anthony List, an antiabortion company, decreased to comment. (In September 2018, the group spearheaded a letter from 45 groups to HHS Secretary Alex Azar that grumbled about U.S. financing for research study that utilizes fetal tissue, assisting catalyze the HHS evaluation.) David Prentice, vice president and research study director at the Charlotte Lozier Institute in Arlington, Virginia, the research study branch of the Susan B. Anthony List, stated he was not available for remark.

Brett Giroir, the physician-scientist who is assistant secretary for health, is leading the broad evaluation of U.S.-funded fetal tissue research study that was introduced in September 2018. Spokespeople at HHS did not react to concerns about the UCSF contract extension or the status of the 5-month-old evaluation, consisting of when it may conclude.

New post published on: https://www.livescience.tech/2019/02/25/united-states-extends-fetal-tissue-contract-and-revives-one-experiment-science/

[cattarattat]

A MUST, MUST, MUST WATCH!!!

"Scientists are speaking out against a directive by the Trump administration that has shut down research into a cure for HIV.

A scientist who was supposed to supply mice that have been modified with human fetal tissue for an HIV study emailed researchers that the Department of Health and Human Services (HHS) 'has directed me to discontinue procuring fetal tissue.'

'This effectively stops all of our research to discover a cure for HIV,' he wrote.

A 'pause' on research that uses aborted fetal tissue, something Christian conservatives strongly oppose, was announced by the Trump administration this past September. The move will affect numerous biomedical research programs.

Congressional Republicans have tried to ban all fetal tissue research for years to appease the religious right. 85 Republican House members wrote a letter to the head of the FDA asking for a ban on fetal tissue research shortly before the 'pause' was announced.

The ban has long been a goal of the anti-abortion industry and has been part of the most recent attacks on Planned Parenthood. The group was falsely accused of selling aborted fetuses earlier this year.

In a statement, the NIH (National Institutes of Health; U. S. Government) (parenthetical mine) said that there is only a 'pause in place' on the research, which is 'an action NIH thought was prudent given the examination of these procurements.'

'We were all poised to go and then the bombshell was dropped,' said Warner Greene, director of the Gladstone Center for HIV Cure Research. Greene was about to collaborate with the Montana lab on HIV research when the project came to a halt.

'The decision completely knocked our collaboration off the rails. We were devastated.'

The study would have relied on fetal tissue donated by women who have had legal abortions in order to produce 'humanized mice,' mice that have human-like immune systems, according to Science. The mice have been used for years for research in infectious diseases, including HIV.

Mice are one of the few non-human animals that can be infected with HIV, which makes them key to testing HIV medication.

Researchers at the lab were going to test a promising antibody they developed to prevent HIV from developing reservoirs, which are cells infected with HIV but are not producing the virus. These cells aren’t affected by currently available HIV medication.

'You spend your life trying to do good experiments and organize your science carefully, and suddenly, at the whim of some politicians in Washington, D.C., they remove a critical piece of your scientific armamentarium,' Greene said.

On September 28, researcher Kim Hasenkrug, who was supposed to provide humanized mice for Greene’s study on the HIV antibody, sent an email to Greene explaining that HHS told them to stop using fetal tissue.

[HHS] has directed me to discontinue procuring fetal tissue from ABR, the only source for us. I think that they are the only provider of fetal tissue for scientists in the nation who don’t have direct access to aborted fetal tissue. This effectively stops all of our research to discover a cure for HIV.

'The mice were ready,' Greene said. 'Just as we’d shipped antibody [to Montana], we were ready to go, and boom, the rug was pulled out from underneath us.'

It is unclear whether non-NIH labs that receive NIH funding will also be banned from using fetal tissue. If so, even more research will be affected.

'Everything I am doing involves humanized mice. It would shut my lab down if we were not able to use fetal tissues,' said Jerome Zack, who has used humanized mice for 25 years to study HIV at UCLA.

But Greene said that the NIH’s actions have already slowed down progress on a cure.

'If we were given the green light right now, it would probably take us a year to get back in the position we were in when the ban was put in place,' he said.

Earlier this year, the Department of Health and Human Services announced a new Conscience and Religious Freedom Division that would handle complaints from health care providers who did not want to take part in an abortion or treat transgender people."

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[fumpkins]

United States extends fetal tissue contract and revives one experiment | Science

Scientists at the federal Rocky Mountain Laboratories in Hamilton, Montana, ​have restarted an HIV study that was interrupted by an order to stop acquiring human fetal tissue.

National Institute of Allergy and Infectious Diseases/National Institutes of Health (CC BY-NC)

The U.S. government’s leading medical research agency is quietly extending and reviving research that relies on human fetal tissue, even as President Donald Trump’s administration ponders the future of the controversial work in a far-reaching review.

Early this month, the National Institutes of Health (NIH) in Bethesda, Maryland, told researchers it intends to extend a key agency contract that funds work using human fetal tissue to develop mice used to test drugs against HIV. Without NIH action, the $2 million annual contract between its National Institute of Allergy and Infectious Diseases (NIAID) and scientists at the University of California, San Francisco (UCSF), will expire on 5 March.

Normally, the contract, which has been in place for years, is renewed each December. But in December 2018, NIH extended it for just 90 days. Officials said the shorter renewal was a response to an ongoing review of federally funded fetal tissue research by the U.S. Department of Health and Human Services (HHS), and that no final decision on the contract’s fate would be made until that review was complete. The newest extension would keep the contract alive for an additional 90 days, through 5 June, according to a 7 February letter from NIH to UCSF obtained under the Freedom of Information Act.

“We are working with NIH to extend the contract. We remain confident that the critically important work of the lab will be continued,” UCSF said in a statement.

NIH has also revived an HIV experiment that was derailed last fall, days after the Trump administration launched a review of all U.S. government–funded research that uses fetal tissue donated by women after elective abortions. The study was being conducted at NIAID’s Rocky Mountain Laboratories (RML) in Hamilton, Montana, where scientists receive fetal tissue that they use to create mice with humanlike immune systems. Lab dish studies had led them to believe that an antibody might prevent HIV from establishing reservoirs in the human body. They were preparing to use the humanized mice in a trial testing the antibody when they received an order from HHS directing them to stop acquiring fetal tissue from Advanced Bioscience Resources, a company in Alameda, California. (Days earlier, HHS had canceled a Food and Drug Administration contract with the company.)

The HHS order “effectively stops all of our research to discover a cure for HIV,” Kim Hasenkrug, lead scientist at RML, wrote at the time to a collaborator, Warner Greene of the Gladstone Center for HIV Cure Research in San Francisco.

Alerted to the experiment’s derailing, Lawrence Tabak, deputy director of NIH, said in December 2018 that the stoppage had resulted from a miscommunication. “We’re now figuring out ways to address that,” Tabak said at that time.

Since then, NIH has found another fetal tissue supplier for the scientists at RML. This allowed the antibody experiment to launch last month, Greene told ScienceInsider yesterday, with 18 mice receiving the antibody and 18 control mice not receiving it. Another cohort of 22 treated mice and 22 controls was launched in early February, and the RML investigators expect in March or April to receive additional mice that will allow more cohorts to be tested, Greene said.

“Our studies are back on track, thanks to the efforts of the NIH,” says Greene, whose lab did early experiments that revealed the antibody’s potential role, and then provided the antibody for the studies. “I just want to emphasize how gratifying it has been to work positively with the NIH on this to solve this problem.” Greene declined to say what supplier is providing fetal tissue for the experiments.

Renate Myles, an NIH spokesperson, wrote in an email today: “The HHS audit is in no way intended to impede research. The delay in Hasenkrug’s research was unintentional and the issue was remediated once we were made of aware of the need for new [fetal tissue] procurement.”

But research advocates praised the NIH for acting. “It’s very important that NIH is finding ways to continue this critical research. The development of these fetal tissue mice currently is the state of the art” in key areas of HIV research, says Sally Temple, scientific director of the Neural Stem Cell Institute in Rensselaer, New York, and a former president of the International Society for Stem Cell Research.

NIH estimates it will spend $95 million on projects involving human fetal tissue this year, down from an estimated $103 million in 2018.

The Susan B. Anthony List, an antiabortion organization, declined to comment. (In September 2018, the group spearheaded a letter from 45 groups to HHS Secretary Alex Azar that complained about U.S. funding for research that uses fetal tissue, helping catalyze the HHS review.) David Prentice, vice president and research director at the Charlotte Lozier Institute in Arlington, Virginia, the research branch of the Susan B. Anthony List, said he was unavailable for comment.

Brett Giroir, the physician-scientist who is assistant secretary for health, is leading the broad review of U.S.-funded fetal tissue research that was launched in September 2018. Spokespeople at HHS did not respond to questions about the UCSF contract extension or the status of the 5-month-old review, including when it might wrap up.

New post published on: https://www.livescience.tech/2019/02/25/united-states-extends-fetal-tissue-contract-and-revives-one-experiment-science/

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