#Hans Ittmann

[welzenis]

In de najaar en wintertentoonstelling werk van Joost Baljeu, Willy Boers, Bram Bogart, Jan Cremer, Jaap Egmond, Geert van Fastenhout, Hans Ittmann, Lucebert, Adolf Luther, Joseph Ongenea, Piet Ouborg, Bernard Frize, Willem Hussem, Pieter de Haard, Bernard Romein, herman de vries, André Volten, Jan Willem van Welzenis, Theo Wolvecamp, Ronald Zuurmond + van vele anderen werk in Stock.

CO | MO is zaterdag- en zondagmiddag geopend van 13.00-1700 uur, Alle andere dagen geopend op afspraak. Wijnstraat 129, Dordrecht. www.como-art.com

[cancersfakianakis1]

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations

Publication date: Available online 18 May 2017 Source:Cancer Cell Author(s): Yiqun Zhang, Patrick Kwok-Shing Ng, Melanie Kucherlapati, Fengju Chen, Yuexin Liu, Yiu Huen Tsang, Guillermo de Velasco, Kang Jin Jeong, Rehan Akbani, Angela Hadjipanayis, Angeliki Pantazi, Christopher A. Bristow, Eunjung Lee, Harshad S. Mahadeshwar, Jiabin Tang, Jianhua Zhang, Lixing Yang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan Seidman, Lovelace J. Luquette, Ruibin Xi, Lynda Chin, Alexei Protopopov, Thomas F. Westbrook, Carl Simon Shelley, Toni K. Choueiri, Michael Ittmann, Carter Van Waes, John N. Weinstein, Han Liang, Elizabeth P. Henske, Andrew K. Godwin, Peter J. Park, Raju Kucherlapati, Kenneth L. Scott, Gordon B. Mills, David J. Kwiatkowski, Chad J. Creighton Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy number, protein, or RNA) were examined across 11,219 human cancers representing 32 major types. Within specific mutated genes, frequency, mutation hotspot residues, in silico predictions, and functional assays were all informative in distinguishing the subset of genetic variants more likely to have functional relevance. Multiple oncogenic pathways including PI3K/AKT/mTOR converged on similar sets of downstream transcriptional targets. In addition to mutation, structural variations and partial copy losses involving PTEN and STK11 showed evidence for having functional relevance. A substantial fraction of cancers showed high mTOR pathway activity without an associated canonical genetic or genomic alteration, including cancers harboring IDH1 or VHL mutations, suggesting multiple mechanisms for pathway activation.

Teaser

Zhang et al. survey the PI3K/AKT/mTOR pathway in >10,000 human cancers across 32 types. In addition to known molecular events, some rare PIK3CA and PIK3R1 mutations activate the pathway, partial copy loss of PTEN or STK11 is associated with poor patient survival, and IDH1 or VHL mutations can confer mTOR activity. http://ift.tt/2rmc2tb

[weepingwidar]

Hans Ittmann (The Netherlands, 1914-1972) - No Title (c. 1953)

[welzenis]

AD DEKKERS ALDOLF LUTHER ANDRE VAN DE VOSSEN ANDRE VOLTEN ANSELM REYLE AURELIE NEMOURS BEN AKKERMAN BERNARD AUBERTIN BERNARD FRIZE BERNARD ROMEIN BOB BONIES BRAM BOGART CALLUM INNES DANIEL LERGON ERIK LINDMAN FLORIAN SCHMIDT GEERT VAN FASTENHOUT GREGOR HILDEBRAND HANS ITTMANN HARTMUT BÖHM HARVEY QUAYTMAN HERBERT HAMAK HERMAN DE VRIES HERMANN BARTELS IMI KNOEBEL JAAP EGMOND JAAP NANNINGA JAAP WAGEMAKER JAN ELBURG JAN JORDENS JAN VAN HEEL JCJ VANDERHEYDEN JEAN GORIN JO DELAHAUT JOOP VREUGDENHILL JOOST BALJEU JORINDE VOIGT JOSEPH LACASSE JOSEPH ONGENAE JUUL NEUMANN KAREL APPEL KURT LEVY LUCEBERT MARK FRANCIS MARTHE WERY MAX BILL MOGENS BALLE NICOLAAS WARB PABLO RASGADO PETER STRUYCKEN PIET OUBORG PIETER DE HAARD ROB VAN KONINGSBRUGGEN RONALD ZUURMOND SEDJE HEMON SHLOMO KOREN THEO WOLVENCAMP WILLEM HUSSEM WILLY BOERS WIM DE HAAN ZAK PREKOP

And me.

https://www.artsy.net/artist/jan-willem-van-welzenis

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