#Genomic Sequencing

[ricisidro]

BA.2.X New #Omicron lineage | via @Tuliodna, @EricTopol

https://x.com/tuliodna/status/1752996491948327126?s=46&t=i2uHiaqre0-vH8-HVYuWsw

As #SARSCoV2 continue to evolve, a new lineage has been detected in South Africa (SA) with >100 mutations (>30 on spike) and multiple deletions.

No sign of widespread, on the opposite, BA.2.86/JN.1 continue to dominate and SA is following the epidemic in many fronts with no sign of increasing cases, hospitalisation and deaths.

#biosurveillance #genomicsurveillance

[iamthekaijuking]

This just in, starfish are a radially symmetrical head with a stomach.

God I love echinoderms

If you told someone that there’s an entire group of animals that develop butt first as embryos are born bilateral but then grow a radially symmetrical head like a cancer in their side that then bursts out and lives as a completely separate organism from its birth form and moves via hydraulic systems…

They wouldn’t believe you. Yet one of the most beloved cartoon characters is one of them.

[yonker-tonker]

Arcee is like a creature to me

[mindblowingscience]

Antibiotics are a lifesaving tool. Yet, due to their chronic overuse, microbes are evolving and developing immunity against them. As a result, once-effective medications can no longer stave off infections, complicating treatment and increasing mortality. A University at Albany study recently published in the journal Nature Communications identified a new genetic mechanism that allows antimicrobial resistance to spread among lethal bacteria.

Continue Reading.

[invinciblevalentine]

hojo pisses me tf off. Like yeah yeah human rights violations unethical science blah blah blah HAVE WE CONSIDERED THE DAMAGE HE’S BEEN DOING TO THE FF7 SCIENTIFIC COMMUNITY????

Listen he’d be a morally grey character if his work led to reproducible results that could benefit the rest of humanity but GOOD GAIA does he not even do that.

his sample sizes are SHIT. his experimental design is SHIT. his documentation is SHIT. his biases are VISIBLE. I’m astral projecting into the ff7 universe just to strangle this man and take away whatever diploma he got bc clearly he hired someone to do his PhD for him.

AND HE INSPIRED SO MANY TO FOLLOW IN HIS SHITTY SHITTY FOOTSTEPS. like the only two things we could even marginally call reproducible is his work in making the SOLDIER program and Fuhitos attempt to replicate it with his RAVENs. and even then there were no improvements on the procedure or attempts to create a procedure that left the patients in better health.

which is a CRIMINALLY STUPID THING TO DO TO YOUR GIANT SUPER SOLDIER ARMY. WYM THAT INSANITY IS JUST A POSSIBLE SIDE EFFECT?????

an argument could be made that we just don’t SEE hojos documentation and shit bc we’re playing through the eyes of people who don’t know all that shit.

HOWEVER. if hojo was actually doing any of that he’d have spotted the degradation problem in his animal models first.

BECAUSE WHO THE FUCK JUMPS YO HUMAN SUBJECTS??? ITS NOT JUST UNETHICAL ITS EXTREMWLY EXPENSIVE TO MAINTAIN THE WELLBEING OF AND ACQUIRE A WHOLE HUMAN PERSON.

if he’d started with, like, mouse models to demonstrate how mako treatments affect mammals, he’d have gotten so much more work done and achieved more reliable results. WITH A FRACTION OF THE COST.

BUT NOOOOOOOOOO. APPARENTLY SHINRA SHITS MONEY SO WHO CARES ABOUT SAMPLE SIZES AND STATISTICAL TESTS AND REPRODUCIBLE RESULTS!!

HOJO IS A HACK AND A FRAUD AND A SHIT SCIENTIST TO BOOT. WATCH YOUR BACK BITCH YOUVE HOED YOUR LAST JO.

[beemovieerotica]

may i suggest davidusjoneium manumos for your bacteria name poll

a;sldkjfal;sdk okay so POTENTIALLY i could name it something really weird but i will absolutely need to have a justification to my boss for why it is named that thing. also this is fairly far off in the future / not 100% certain because i still have to do all the shit required of describing a new species

[dailycupofcreativitea]

Fun bio things

My coworker and I were fighting for our lives in the last 30 minutes before winter break (we're off at noon today) trying to hand-translate genomic sequence like we were back in second year biology so we could figure out how to merge an insertion and a deletion LOL

It was an insertion of a GG (shifts the frame +2) and a deletion of an A (shifts the frame -1) that were two separate calls, but we were trying to combine them. The insGG caused a stop codon at position 43, and the delA caused a stop codon at position 42, but the combined frameshift (+2 - 1 = +1) didn't make a stop codon, so we were like...okay then what's the new notation...

I'm pretty sure the new notation is something like fs*? (a frameshift but you have no idea when it makes a stop) but this is me digging in my brain for second year biology and even then I don't think we learned this HAHA

[o-sachi]

My friends always tell me about that one time they decided to have a drink while writing an important paper.

And I’m like, “how tf u gonna think properly and write a long ass paper then?”

But after doing it myself, i get it!

It doesn’t make me write better but it sure does make me feel less miserable 😃

[cbirt]

The sequencing and assembly of the human Y chromosome have been challenging due to its intricate repeat structure, which encompasses lengthy palindromes, tandem repeats, and segmental duplications. The existing GRCh38 reference sequence lacks over half of the Y chromosome’s content, leaving it as the final unfinished human chromosome. Addressing these limitations, the Telomere-to-Telomere (T2T) consortium introduces the full 62,460,029-base-pair sequence of the human Y chromosome from the HG002 genome (T2T-Y). This new sequence rectifies multiple errors in GRCh38-Y, supplementing the reference with over 30 million base pairs. It reveals complete ampliconic patterns of gene families like TSPY, DAZ, and RBMY, adds 41 protein-coding genes (primarily from TSPY), and unveils a distinctive alternating arrangement of human satellite 1 and 3 blocks within the heterochromatic Yq12 region. Through integration with the CHM13 genome assembly and the inclusion of population variations, clinical variants, and functional genomics data, a comprehensive reference spanning all 24 human chromosomes has been established.

The complex architecture of the human Y chromosome, with its large repeats and palindromes, plays a pivotal role in fertility. This includes hosting genes that are crucial for spermatogenesis and sex determination. Although it remains notably incomplete due to over half of its makeup being riddled with gaps in the GRCh38 human reference genome, this condition impedes comprehensive analysis of regions such as Azoospermia factors associated with infertility.

Despite these challenges, breakthroughs from the Telomere-to-Telomere (T2T) consortium have allowed researcher Adam M. Phillippy and his team to assemble the entire CHM13 cell line genome; however, they could not fully put together the Y chromosome because of its unique characteristics. The Human Pangenome Reference Consortium (HPRC) concurrently launched a project to embody a broader genomic range via the use of the HG002 genome. This endeavor successfully resulted in the reconstruction of the full sequence for the Y chromosome, known as T2T-Y.

Continue Reading

[eeleye-mcshitposts]

ONE of these fucks does NOT belong.

[everythingaboutbiotech]

Common uses of bioinformatics

💡Sequence analysis Analyzing DNA and protein sequences to identify genes, regulatory regions & mutations.

💡Gene expression Analyzing RNA expression data from experiments like microarrays or RNA-seq to understand gene regulation.

💡Phylogenetics Constructing evolutionary relationships between organisms based on genetic data and genomic comparisons.

💡Molecular modeling Predicting protein structure and docking drugs to proteins using computational modeling and simulation.

💡Databases & Data mining Developing databases like GenBank to store biological data and mining it to find patterns.

💡Genomics Studying entire genomes, including sequencing and assembling genomes as well as identifying genes and genomic variations.

Follow @everythingaboutbiotech for useful posts.

[aunteutis]

god, ben stiller's music taste in this is so good

[jewishdragon]

When a computer slows down bc its processing a shit ton of sequencing data i say "gotta be patient, the computer is doing a big thinkie"

[smol-blue-bird]

I love old books about the future. Currently reading The Physics of the Future by Michio Kaku, and he keeps saying that humans will one day be able to fit their genomes on a CD-ROM

[dollelujah]

These pride advertisements are getting out of hand

[ladysqueakinpip]

the only thing my sister and i have to offer to the rise fandom is theories about how lou jitsu's dna recombined with the turtles