#GS-441524

[meowmoedotcom]

きっかけはウイルスの突然変異ではなかった…【FIPの真(新)事実】

meowmoe.com

[laserpaper118]

My cat is 6y5m old, he was diagnosed with ocular type dry FIP

He had subcutaneous injections of GS-441524 for 13 days, he was eating and drinking and moving around and sleeping in my bed but developed really bad injection sores so a switch was made to oral formulation

After 1 single capsule 2 days ago, he became lethargic and kept vomiting, so I had him admitted to the vet clinic. Yesterday he had IV fluids, anti-emetic meds, and a second capsule mixed with soft food. I last saw him 7 hours ago, he was very weak but I know he sensed me there. He also kept vomiting today.

Tonight he developed respiratory distress. He passed 16 minutes ago. My vet and her vet paramedics videotaped the whole critical condition and their interventions, which I am grateful for.

On the one hand I wish he was home with me, right now at almost 9pm, so I can have him go through his last moments in my arms. He must have been so scared and in pain and discomfort.

On the other hand, had I just decided to let him stay home and cuddled him without letting him receive supportive treatment, however futile, I may never forgive myself, and constantly torture myself with what-ifs.

I can't talk about this anywhere else bcos I don't think I have catlover friends who love their cats as much as I do, so. Yeah. Bear with me, guys.

My world just split clean in two

[floralsapphics]

.

[release-the-hound]

Do y'all ever think about how wild it is that for years there's been this heartbreaking incurable disease that kills thousands of cats. And Gilead Pharmaceuticals found a drug that treats it but won't actually sell it to veterinarians because of patent bullshit? Because I do.

Anyways. I'd never advocate for acquiring drugs illegally to save your cat's life. Which is why if your cat has FIP you should check out the organization I've put in my tags. So that you remember to avoid getting GS-441524.

Capitalism is evil in general. But capitalism in medicine is cartoonishly monstrous.

[mamaspark]

This is from a friend on FB.

BEST. NEWS. EVER !

“Happy Friday everyone! FIP Global CATS has been supporting treatment for FIP cats for years, but our dream and goal has always been legal treatment available through veterinarians. Today I have an exciting announcement that legal treatment with GS-441524 will be available in the US starting June 1!

Stokes pharmacy in the US has partnered with BOVA to bring legally compounded GS tablets to the US. The tablets will be compounded in the US in a formulation identical to the BOVA formulation currently in use in the UK and Australia. Availability begins starting June 1!

Pricing is not yet available, but I'll share more information as I have it!”

My cat, Cole, had FIP. The only way he survived it was by me obtaining treatment through the secondary market. The network is extensive and the medicine expensive. I’m super excited for it to be legal and available here in the US!

Please reblog and share share SHARE!

This is my healthy best friend! He turned 7 this year. Without treatment I would have lost him after only 3 years. 🖤🐈‍⬛🖤

[followthebluebell]

If by some entirely legal means you happen to be treating a cat with fip using injections of gs 441524, it's very important to rotate the injection site. You can't just inject the cat in the same spot every day.

While it's a lifesaving drug, it's also very caustic and causes some fairly nasty skin lesions if it gets on the skin (which I suspect is what happened here, in addition to not rotating the injection site).

[ruderubicante]

I'd just like to say the outpour of help and support I've received is nothing short of miraculous and I cannot thank everyone enough for helping me get word about Spooky out, commissioning me and donating what they can.

Of course, she's not out of the woods yet. Her last dose of remdesivir is hopefully tomorrow and after that she'll be on GS-441524 for the next 12 weeks. But here she is, at home (Leaning on her cannula!!! NOOO!!!) and looking very mad at me.

[lovesnapcats]

WHITE (WHY IS THIS KITTY STILL HERE?!) CAT WEDNESDAY!

Bea is 3 years 2 months-old and sponsored by Leah Hennen. SNAP Cats rescued Bea from Oakland, CA. Bea does not have any special needs because she came to us bonded with her brother, Bertie, who is a dwarf kitty with ataxia. Once they were here for a while, the two de-bonded (is that a word?), and Bertie was adopted in November 2021.

Bea is the typical, playful cat who can’t seem to run out of energy. Bea LOVES to chase the spring toy. Keeps her entertained for hours. Bea will make a wonderful addition to any family who has a cat or two about her age. If you don't have a cat or two, we can also help with that!

Please note that Bea underwent GS-441524 treatment for FIP in the beginning of 2022. Since her treatment ended in March 2022, her response to the treatment has been extremely positive. Bea shows absolutely no signs of FIP at all. Although we can’t guarantee she won’t develop FIP again (we can’t guarantee ANY cat won’t develop FIP), we’re almost certain that she won’t since she's gone more than two years without any signs of it returning.

If you’re interested in Bea please fill out an adoption application at https://www.snapcats.org/category/adoption/catsforadoption/. Thanks.

SNAP Cats uses Smart Cat, all natural cat litter.

[lexyeevee]

sometimes i think about trying to make use of tumblr again but like. well for one i don't even know who i know who uses it still

but also my associations with tumblr are mostly about callouts, from a time when blocking didn't even meaningfully work, which made them this inescapable plague because people just had like half a dozen ways to put things on your screen that you couldn't prevent.

like the post history of this blog is currently mostly people spewing vitriol and me being angry about that and spewing it right back, which is just unpleasant all around

but even before that... i think of stuff like posting about styx's then-incurable illness, which he was swiftly dying from. because i always liked trying to be open about personal things, and i liked the idea of keeping some kind of record of a major thing, even if it was a catastrophe. but now i associate that with someone misunderstanding the posts and straight up accusing me of killing my cat.

(by the way FIP is no longer a death sentence — there is an antiviral called merely GS-441524 that is not FDA approved for vet use because of some corporate malarkey so you have to get it yourself but it is unbelievably effective, this sounds so fake i know but it is extremely real and there are even like facebook groups where people pass their unused doses around)

anyway i guess that sort of thing makes it hard to dive back in

[champawattigress]

Not enough has been written about FIP Warriors and GS-441524, and I really wish I had the energy to do so.

[petnews2day]

Overdue good news arrives for FIP cats in the US - News

New Post has been published on https://petn.ws/Ei8r8

Overdue good news arrives for FIP cats in the US - News

Tawny before after Photos by Wendy Novicoff Tawny was diagnosed in 2020 at age four months with a form of feline infectious peritonitis that affected her eyes (top). Her owner, Wendy Novicoff, quickly began treating her with an imported compound she obtained through contacts on Facebook. It was likely a version of GS-441524, an antiviral […]

See full article at https://petn.ws/Ei8r8 #CatsNews

[rnomics]

Viruses, Vol. 16, Pages 462: Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials

Feline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with a genetic variant of feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from four different antiviral clinical trials performed at the University of California, Davis. Collectively, a total of 60 client-owned domestic cats, each with a confirmed diagnosis of naturally occurring FIP, were treated with a variety of antiviral compounds. The tested therapies included the antiviral compounds GS-441524, remdesivir, molnupiravir and allogeneic feline mesenchymal stem/stroma cell transfusions. Four client-owned cats with FIP did not meet the inclusion criteria for the trials and were not treated with antiviral therapies; these cats were included in the data set as untreated FIP control cats. ELISA and Western blot assays were performed using feline serum/plasma or ascites effusions obtained from a subset of the FIP cats. Normalized tissue/effusion viral loads were determined in 34 cats by a quantitative RT-PCR of nucleic acids isolated from either effusions or abdominal lymph node tissue. Twenty-one cats were PCR “serotyped” (genotyped) and had the S1/S2 region of the coronaviral spike gene amplified, cloned and sequenced from effusions or abdominal lymph node tissue. In total, 3 untreated control cats and 14 (23.3%) of the 60 antiviral-treated cats died or were euthanized during (13) or after the completion of (1) antiviral treatment. Of these 17 cats, 13 had complete necropsies performed (10 cats treated with antivirals and 3 untreated control cats). We found that anticoronaviral serologic responses were persistent and robust throughout the treatment period, primarily the IgG isotype, and focused on the viral structural Nucleocapsid and Membrane proteins. Coronavirus serologic patterns were similar for the effusions and serum/plasma of cats with FIP and in cats entering remission or that died. Viral #RNA was readily detectable in the majority of the cats in either abdominal lymph node tissue or ascites effusions, and all of the viral isolates were determined to be serotype I FIPV. Viral nucleic acids in cats treated with antiviral compounds became undetectable in ascites or abdominal lymph node tissue by 11 days post-treatment using a sensitive quantitative RT-PCR assay. The most common pathologic lesions identified in the necropsied cats were hepatitis, abdominal effusion (ascites), serositis, pancreatitis, lymphadenitis, icterus and perivasculitis. In cats treated with antiviral compounds, gross and histological lesions characteristic of FIP persisted for several weeks, while the viral antigen became progressively less detectable. https://www.mdpi.com/1999-4915/16/3/462?utm_source=dlvr.it&utm_medium=tumblr

[amcrasto]

Oditrasertib,

Obeldesivir, 2647441-36-7 361.35 g/mol C16H19N5O5 [(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methyl 2-methylpropanoate Q55KCM7PXB; ATV006; UNII-Q55KCM7PXB Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high…

[reneleijen]

Belgie: Online handel in illegaal kattenmedicijn tegen covid opgerold

Belgie: Online handel in illegaal kattenmedicijn tegen covid opgerold

Met een gezamenlijke actie hebben de polities van België en Nederland een internethandeltje in een illegaal kattencoronamedicijn opgerold. In totaal zijn zes mensen aangehouden. De bende handelde op facebook in het middel GS-441524, dat in het alternatieve circuit wordt aangeprezen als middel tegen covid bij katten. Een dosis kost circa drie mille. Het spul is vermoedelijk afkomstig uit China of…

[ask-a-vetblr]

re: FIP and treatment (or lack thereof) - what's the professional opinion on the antiviral GS-441524? there's a whole network of cat owners getting it on the black market, and it seems to work in the short to medium term, but is it actually a cure?

gettingvetted here.

I am in the veterinarian-specific group surrounding the drug. A bunch of us are just there for learning purposes and to potentially help future clients, but many people have either helped their clients using the drug or have used it on their own cats. It seems to have a very high success rate and puts a majority of cats into remission. The issue is obtaining it, and the cost associated with doing so.