#GS-441524

[trenchkamen]

I had to help get a cat access to GS-441524. pH 1.5 formulation (I thought that had to be a typo when I first read it—what the FUCK) but almost 100% cure for a formerly 100% lethal disease

I had no idea they were proceeding with the FIP research wrt Remdesivir in felines.

I think I’m going to start crying.

I thought they’d never revisit the study because they did not want complications in feline patients to jeopardize or complicate Remdesivir approval in humans. Bile-spitting furious that we had a cure for a previously 100% lethal disease the company couldn’t be arsed to release in a better feline formulation and stuck people with scrambling on the black market for a many months long, painful regime.

I corresponded with the PI of the original studies at Davis (I’m a molecular biologist) and he could not, for legal reasons, tell me much, but I can only imagine how heartbroken he was to know he had A 100% CURE FOR A PREVIOUSLY 100% LETHAL DISEASE (that is the kind of slam dunk discovery beyond the wildest imaginings of most scientists, a daydream) that was sitting around because the companies saw a potential financial/regulatory headache to get it sorted.

I am so happy. For you, for Belphie, and for all the cats who will get FIP in the future.

it's more like a "study".

I spoke to the vet in charge, and he said that he'd been traumatized hearing the screams of FIP cats being injected with GS-441524. it burns going in, and can leave pretty horrific lesions on the skin.

the black market injections were all that was available at the time, so he arranged this scheme as a way of making the oral compound of GS-441524 available to owners. basically, the drug is so new that it hasn't been legally cleared yet, but because it's a "medical study" they can supply it, so long as they collect information. that's why I need to keep updating them on Belphie's weight and doing blood tests, until we clear the study.

this is a small clinic in a small town that's treated 408 cats with FIP, so I really don't blame them for making me pay! honestly, I'm just grateful that I don't have to torture Belphie with painful injections.

[laserpaper118]

My cat is 6y5m old, he was diagnosed with ocular type dry FIP

He had subcutaneous injections of GS-441524 for 13 days, he was eating and drinking and moving around and sleeping in my bed but developed really bad injection sores so a switch was made to oral formulation

After 1 single capsule 2 days ago, he became lethargic and kept vomiting, so I had him admitted to the vet clinic. Yesterday he had IV fluids, anti-emetic meds, and a second capsule mixed with soft food. I last saw him 7 hours ago, he was very weak but I know he sensed me there. He also kept vomiting today.

Tonight he developed respiratory distress. He passed 16 minutes ago. My vet and her vet paramedics videotaped the whole critical condition and their interventions, which I am grateful for.

On the one hand I wish he was home with me, right now at almost 9pm, so I can have him go through his last moments in my arms. He must have been so scared and in pain and discomfort.

On the other hand, had I just decided to let him stay home and cuddled him without letting him receive supportive treatment, however futile, I may never forgive myself, and constantly torture myself with what-ifs.

I can't talk about this anywhere else bcos I don't think I have catlover friends who love their cats as much as I do, so. Yeah. Bear with me, guys.

My world just split clean in two

[floralsapphics]

.

[release-the-hound]

Do y'all ever think about how wild it is that for years there's been this heartbreaking incurable disease that kills thousands of cats. And Gilead Pharmaceuticals found a drug that treats it but won't actually sell it to veterinarians because of patent bullshit? Because I do.

Anyways. I'd never advocate for acquiring drugs illegally to save your cat's life. Which is why if your cat has FIP you should check out the organization I've put in my tags. So that you remember to avoid getting GS-441524.

Capitalism is evil in general. But capitalism in medicine is cartoonishly monstrous.

[mamaspark]

This is from a friend on FB.

BEST. NEWS. EVER !

“Happy Friday everyone! FIP Global CATS has been supporting treatment for FIP cats for years, but our dream and goal has always been legal treatment available through veterinarians. Today I have an exciting announcement that legal treatment with GS-441524 will be available in the US starting June 1!

Stokes pharmacy in the US has partnered with BOVA to bring legally compounded GS tablets to the US. The tablets will be compounded in the US in a formulation identical to the BOVA formulation currently in use in the UK and Australia. Availability begins starting June 1!

Pricing is not yet available, but I'll share more information as I have it!”

My cat, Cole, had FIP. The only way he survived it was by me obtaining treatment through the secondary market. The network is extensive and the medicine expensive. I’m super excited for it to be legal and available here in the US!

Please reblog and share share SHARE!

This is my healthy best friend! He turned 7 this year. Without treatment I would have lost him after only 3 years. 🖤🐈‍⬛🖤

[followthebluebell]

If by some entirely legal means you happen to be treating a cat with fip using injections of gs 441524, it's very important to rotate the injection site. You can't just inject the cat in the same spot every day.

While it's a lifesaving drug, it's also very caustic and causes some fairly nasty skin lesions if it gets on the skin (which I suspect is what happened here, in addition to not rotating the injection site).

[lovesnapcats]

WHITE (WHY IS THIS KITTY STILL HERE?!) CAT WEDNESDAY!

Bea is 3 years 4 months-old and sponsored by Leah Hennen. SNAP Cats rescued Bea from Oakland, CA. Bea does not have any special needs because she came to us bonded with her brother, Bertie, who is a dwarf kitty with ataxia. Once they were here for a while, the two de-bonded (is that a word?), and Bertie was adopted in November 2021.

Bea is the typical, playful cat who can’t seem to run out of energy. Bea LOVES to chase the spring toy. Keeps her entertained for hours. Bea will make a wonderful addition to any family who has a cat or two about her age. If you don't have a cat or two, we can also help with that!

Please note that Bea underwent GS-441524 treatment for FIP in the beginning of 2022. Since her treatment ended in March 2022, her response to the treatment has been extremely positive. Bea shows absolutely no signs of FIP at all. Although we can’t guarantee she won’t develop FIP again (we can’t guarantee ANY cat won’t develop FIP), we’re almost certain that she won’t since she's gone more than two years without any signs of it returning.

If you’re interested in Bea please fill out an adoption application at https://www.snapcats.org/category/adoption/catsforadoption/. Thanks.

SNAP Cats uses Smart Cat, all natural cat litter.

[ruderubicante]

I'd just like to say the outpour of help and support I've received is nothing short of miraculous and I cannot thank everyone enough for helping me get word about Spooky out, commissioning me and donating what they can.

Of course, she's not out of the woods yet. Her last dose of remdesivir is hopefully tomorrow and after that she'll be on GS-441524 for the next 12 weeks. But here she is, at home (Leaning on her cannula!!! NOOO!!!) and looking very mad at me.

[msexcelfractal]

Left, GS-441524. Antiviral. Right, Doxycycline. Antibacterial.

Left, Furosemide. Loop diuretic - treats edema (tissue swelling due to fluid retention). Right, Dexmethasone. Anti-inflamatory steroid.

[lexyeevee]

sometimes i think about trying to make use of tumblr again but like. well for one i don't even know who i know who uses it still

but also my associations with tumblr are mostly about callouts, from a time when blocking didn't even meaningfully work, which made them this inescapable plague because people just had like half a dozen ways to put things on your screen that you couldn't prevent.

like the post history of this blog is currently mostly people spewing vitriol and me being angry about that and spewing it right back, which is just unpleasant all around

but even before that... i think of stuff like posting about styx's then-incurable illness, which he was swiftly dying from. because i always liked trying to be open about personal things, and i liked the idea of keeping some kind of record of a major thing, even if it was a catastrophe. but now i associate that with someone misunderstanding the posts and straight up accusing me of killing my cat.

(by the way FIP is no longer a death sentence — there is an antiviral called merely GS-441524 that is not FDA approved for vet use because of some corporate malarkey so you have to get it yourself but it is unbelievably effective, this sounds so fake i know but it is extremely real and there are even like facebook groups where people pass their unused doses around)

anyway i guess that sort of thing makes it hard to dive back in

[pangur-and-grim]

a lot of you probably knows Belphie's story, but I'll summarize just in case.

Devon Rex cats are better for people with allergies (less shed fur + less Fel d1 protein in their saliva), so on February 16, 2024, I went the breeder route and put down a deposit. before Belphie even opened his eyes, he was mine!

every Friday, the breeder sent me a new photo. I had a broken leg, and was basically rotting in bed at that point, so it was the best part of my week. then, at 12 weeks old, I BROUGHT HIM HOME!

at first, he was so alive! like a wind-up monkey that never shut off. he dangled from the wall-hangings, savaged my feet as I walked, and used my elderly cats as jumping poles to do cool acrobatics over. but all this gradually faded.

first, he stopped playing. then he stopped climbing. then he stopped moving much at all. my vet ran tests on him and found multiple pathogens (calcivrius + mycoplasma), but the medication didn't help - he kept declining.

on September 17th, I woke up to find him swollen like a balloon. we finally had an answer: he had Feline infectious Peritonitis, aka FIP. before 2017, this would've been a death sentence. he would've kept bloating until he drowned in his own fluids. and before 2024, I would've been forced to inject him with black market drugs. but thankfully, South Tower Animal Hospital in Fergus, Ontario was doing a study on the oral medication! we drove two hours, enrolled him, and left with the GS-441524 pills.

and he went from those photos above.....to this:

I thought Belphie would die as a kitten. I'd accepted that he would never grow up. but now he gets to LIVE!

and all for the low cost of $7,553.....ahhhahaha........god.

that + a recent home disaster has wiped out my savings, but I still need to pay for Belphie's medication. to remain in this study, I need to do bloodwork monthly until Feb 2025, and he'll need daily pills until March 2025.

I've put a risograph print + enamel pin set up at greerstothers.shop. I hate asking for help, but if you'd like to support Belphie's continued treatment, please consider checking them out!

[champawattigress]

Not enough has been written about FIP Warriors and GS-441524, and I really wish I had the energy to do so.

[petnews2day]

Overdue good news arrives for FIP cats in the US - News

New Post has been published on https://petn.ws/Ei8r8

Overdue good news arrives for FIP cats in the US - News

Tawny before after Photos by Wendy Novicoff Tawny was diagnosed in 2020 at age four months with a form of feline infectious peritonitis that affected her eyes (top). Her owner, Wendy Novicoff, quickly began treating her with an imported compound she obtained through contacts on Facebook. It was likely a version of GS-441524, an antiviral […]

See full article at https://petn.ws/Ei8r8 #CatsNews

[rnomics]

Viruses, Vol. 16, Pages 462: Serologic, Virologic and Pathologic Features of Cats with Naturally Occurring Feline Infectious Peritonitis Enrolled in Antiviral Clinical Trials

Feline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with a genetic variant of feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from four different antiviral clinical trials performed at the University of California, Davis. Collectively, a total of 60 client-owned domestic cats, each with a confirmed diagnosis of naturally occurring FIP, were treated with a variety of antiviral compounds. The tested therapies included the antiviral compounds GS-441524, remdesivir, molnupiravir and allogeneic feline mesenchymal stem/stroma cell transfusions. Four client-owned cats with FIP did not meet the inclusion criteria for the trials and were not treated with antiviral therapies; these cats were included in the data set as untreated FIP control cats. ELISA and Western blot assays were performed using feline serum/plasma or ascites effusions obtained from a subset of the FIP cats. Normalized tissue/effusion viral loads were determined in 34 cats by a quantitative RT-PCR of nucleic acids isolated from either effusions or abdominal lymph node tissue. Twenty-one cats were PCR “serotyped” (genotyped) and had the S1/S2 region of the coronaviral spike gene amplified, cloned and sequenced from effusions or abdominal lymph node tissue. In total, 3 untreated control cats and 14 (23.3%) of the 60 antiviral-treated cats died or were euthanized during (13) or after the completion of (1) antiviral treatment. Of these 17 cats, 13 had complete necropsies performed (10 cats treated with antivirals and 3 untreated control cats). We found that anticoronaviral serologic responses were persistent and robust throughout the treatment period, primarily the IgG isotype, and focused on the viral structural Nucleocapsid and Membrane proteins. Coronavirus serologic patterns were similar for the effusions and serum/plasma of cats with FIP and in cats entering remission or that died. Viral #RNA was readily detectable in the majority of the cats in either abdominal lymph node tissue or ascites effusions, and all of the viral isolates were determined to be serotype I FIPV. Viral nucleic acids in cats treated with antiviral compounds became undetectable in ascites or abdominal lymph node tissue by 11 days post-treatment using a sensitive quantitative RT-PCR assay. The most common pathologic lesions identified in the necropsied cats were hepatitis, abdominal effusion (ascites), serositis, pancreatitis, lymphadenitis, icterus and perivasculitis. In cats treated with antiviral compounds, gross and histological lesions characteristic of FIP persisted for several weeks, while the viral antigen became progressively less detectable. https://www.mdpi.com/1999-4915/16/3/462?utm_source=dlvr.it&utm_medium=tumblr

[amcrasto]

Oditrasertib,

Obeldesivir, 2647441-36-7 361.35 g/mol C16H19N5O5 [(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methyl 2-methylpropanoate Q55KCM7PXB; ATV006; UNII-Q55KCM7PXB Obeldesivir (GS-5245, ATV006) is an isobutyric ester prodrug of GS-441524 made by Gilead Sciences that is currently in Phase III trials for the outpatient treatment of COVID-19 in high…