#Epistaxis Treatment Market
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The Epistaxis Treatment Market sector is undergoing rapid transformation, with significant growth and innovations expected by 2028. In-depth market research offers a thorough analysis of market size, share, and emerging trends, providing essential insights into its expansion potential. The report explores market segmentation and definitions, emphasizing key components and growth drivers. Through the use of SWOT and PESTEL analyses, it evaluates the sector’s strengths, weaknesses, opportunities, and threats, while considering political, economic, social, technological, environmental, and legal influences. Expert evaluations of competitor strategies and recent developments shed light on geographical trends and forecast the market’s future direction, creating a solid framework for strategic planning and investment decisions.
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Which are the top companies operating in the Epistaxis Treatment Market?
The report profiles noticeable organizations working in the water purifier showcase and the triumphant methodologies received by them. It likewise reveals insights about the share held by each organization and their contribution to the market's extension. This Global Epistaxis Treatment Market report provides the information of the Top Companies in Epistaxis Treatment Market in the market their business strategy, financial situation etc.
Novartis AG, Noramco, Mallinckrodt, Johnson & Johnson Health Care Systems Inc., Teva Pharmaceuticals USA, Inc., Camber Pharmaceuticals, Inc., Amneal Pharmaceuticals LLC, Lannett, Takeda Pharmaceutical Company Limited, Zydus Cadila, Par Pharmaceutical, Aurobindo Pharma USA, AdvaCare Pharma, Pfizer Inc., Angiplast, Sterimed Group, Cardinal Health, Elanor Surgicals, hitecmed, B.F. ASCHER & CO., INC., Bayer, Smith & Nephew
Report Scope and Market Segmentation
Which are the driving factors of the Epistaxis Treatment Market?
The driving factors of the Epistaxis Treatment Market are multifaceted and crucial for its growth and development. Technological advancements play a significant role by enhancing product efficiency, reducing costs, and introducing innovative features that cater to evolving consumer demands. Rising consumer interest and demand for keyword-related products and services further fuel market expansion. Favorable economic conditions, including increased disposable incomes, enable higher consumer spending, which benefits the market. Supportive regulatory environments, with policies that provide incentives and subsidies, also encourage growth, while globalization opens new opportunities by expanding market reach and international trade.
Epistaxis Treatment Market - Competitive and Segmentation Analysis:
North America, particularly the United States, will continue to exert significant influence that cannot be overlooked. Any shifts in the United States could impact the development trajectory of the Epistaxis Treatment Market. The North American market is poised for substantial growth over the forecast period. The region benefits from widespread adoption of advanced technologies and the presence of major industry players, creating abundant growth opportunities.
Similarly, Europe plays a crucial role in the global Epistaxis Treatment Market, expected to exhibit impressive growth in CAGR by 2028.
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Key Benefits for Industry Participants and Stakeholders: –
Industry drivers, trends, restraints, and opportunities are covered in the study.
Neutral perspective on the Epistaxis Treatment Market scenario
Recent industry growth and new developments
Competitive landscape and strategies of key companies
The Historical, current, and estimated Epistaxis Treatment Market size in terms of value and size
In-depth, comprehensive analysis and forecasting of the Epistaxis Treatment Market
Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historical data and forecast (2024-2028) of the following regions are covered in Chapters
The countries covered in the Epistaxis Treatment Market report are U.S., Canada, Mexico, Brazil, Argentina, Rest of South America, Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific, Saudi Arabia, U.A.E, South Africa, Egypt, Israel, and Rest of the Middle East and Africa
Detailed TOC of Epistaxis Treatment Market Insights and Forecast to 2028
Part 01: Executive Summary
Part 02: Scope Of The Report
Part 03: Research Methodology
Part 04: Epistaxis Treatment Market Landscape
Part 05: Pipeline Analysis
Part 06: Epistaxis Treatment Market Sizing
Part 07: Five Forces Analysis
Part 08: Epistaxis Treatment Market Segmentation
Part 09: Customer Landscape
Part 10: Regional Landscape
Part 11: Decision Framework
Part 12: Drivers And Challenges
Part 13: Epistaxis Treatment Market Trends
Part 14: Vendor Landscape
Part 15: Vendor Analysis
Part 16: Appendix
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Global Epistaxis Market Outlook (2022 to 2032)
The global epistaxis market is evaluated at USD 193.5 Million in 2022 and is forecast to outshine USD 332.0 Million by 2032, mounting at a CAGR of 5.5% from 2022 to 2032.
Global epistaxis market is holding nearly 1% market share in global ear nose and throat (ENT) treatment market which is likely to grow at a CAGR of 6% during the forecast years.
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The readability score of the Epistaxis Market Demand report is good as it offers chapter-wise layout with each section divided into a smaller sections.
The report encompasses graphs and tables to show the entire assembling. Pictorial demonstration of the definite and estimated values of key segments is visually appealing to readers.
This Epistaxis market outlook report explicates on vital dynamics such as the drivers, restraints and opportunities for key players and competitive analysis of Epistaxis along with key stakeholders as well as emerging players associated with the manufacturing of product.
Competitive Landscape: Top Companies in Epistaxis Market
To recover diffusion across profitable markets, the aforementioned players use various organic and inorganic strategies. Product launches, alliances and agreements with key epistaxis suppliers, acquisitions, and geographical expansion are all part of these strategies.
Fact.MR has provided detailed information about price points of top providers in epistaxis market positioned across regions, sales growth, production capacity, and speculative technological expansion in the recently published report.
For instance:
In August 2021, the company Pfizer Inc. has signed an agreement to acquire Trillium Therapeutics Inc., this acquisition will help company to strengthen the company’s presence in global market
In January 2022, Ascend Wellness Holdings has signed a partnership agreement with Siemens Healthineers, to expand the its testing capacity in the Ascend’s new laboratory in California
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How will be insights and market estimations provided in the report on the Demand of Epistaxis make a difference?
The study takes a closer look at the major economic turmoil, with a focus on the recent COVID-19 pandemic disruptions
The assessment of key growth dynamics highlights the attractiveness of new automation technologies and offers readers insight on the prospect of these during the forecast period
The study tries to offer a balance perspective of the opportunities in mature and the most lackluster markets
Provides scrutiny of the industry trends that have shaped recent government policies
Provides an account of major breakthroughs in all segments that might change the course of the market considerably
Provides an incisive analysis of socio-political milieu in which the key markets operate, and how will that influence the lucrativeness of the overall Epistaxis Market
Analyzes how collaborations and partnerships among players from different industries shape the key growth dynamics in the near future
Evaluates the role of various stages of funding on new growth avenues in key regional markets
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#Martsolf Syndrome Treatment Market Share#Martsolf Syndrome Treatment Market size#Martsolf Syndrome Treatment Market trends#Martsolf Syndrome Treatment Market forecast
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Global Nosebleeds Market, Treatment Type (Vasoconstrictors, Anesthetics, Antibiotic Ointments, Cauterizing Agents, Others), Route of Administration (Oral, Intranasal, Others), Indication (Posterior Epistaxis, Anterior Epistaxis), End-Users (Hospitals, Specialty Clinics, Homecare, Others), Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Online Pharmacy, Others) – Industry Trends and Forecast to 2029
#Nosebleeds_Market_Size#Nosebleeds_Market_Share#Nosebleeds_Market_Trends#Nosebleeds_Market_Growth#Nosebleeds_Market_Demand#Nosebleeds_Market_Analysis
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Orogastric Devices Market Estimated to Observe Technological Advancements Further
Orogastric Devices Market: Introduction
· Orogastric devices are small tubes placed either through the mouth and the end with the tip in the stomach, or placed through the nose as per requirement. NG/OG (Nasogastric/Orogastric) tubes may be used for feedings, medication administration, or removal of contents from the stomach via aspiration, suction, or gravity drainage.
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· Generally, the patient is given an orogastric tube in cases where specially prepared liquid food or fluids are required to be fed directly into the stomach. Orogastric tube is used in case of issues with sucking and swallowing, dehydration from vomiting/diarrhoea and not drinking enough, lack of nutrition through the normal diet, or the patient is unable to swallow the medications. In some cases, it is also used to empty the contents of the patient’s stomach, including stomach gases. The tube is inserted by an experienced pediatric surgeon directly through the mouth and into the stomach.
· Orogastric tube placement is a common procedure routinely used in clinical anesthesiology and intensive care medicine. It is usually performed by only experienced doctors or nurses. It is also suggested to withdraw the tube promptly into the oropharynx if the patient has excessive choking, gagging, coughing, a change in voice, or the appearance of condensation on the inner aspect of the tube.
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Key Drivers, Restraints, and Opportunities of Global Orogastric Devices Market
· Increase in incidence of diseases among infants, which makes them weak, is a major cause for the rise in preference for orogastric devices as a feeding tool, which is a key factor driving the global orogastric tube market
· Caustic ingestion or oesophageal strictures (risk of perforation), coagulopathy (epistaxis risk), base of skull fracture, severe mid-face trauma are a few rare occurring conditions of using the orogastric tube
· Slit endotracheal tubes, a new type of gastric tube guide (VBM Medizintechnik GmbH, Sulz, Germany), has been designed to facilitate the insertion of orogastric devices. The device is made of polyvinyl chloride. This is estimated to create further opportunity for global orogastric tube market.
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North America to Capture Major Share of Global Orogastric Devices Market
· The U.S. held a major share of the global orogastric tube market due to the awareness among people about the use of orogastric devices, which in turn drives the orogastric devices market
· The orogastric devices market in Asia Pacific is estimated to expand at a prominent pace due to an increase in birth rate. Furthermore, maternal malnutrition in low income countries in the region lead to the birth of infants with issues that require orogastric tube for the purpose of feeding.
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Key Players Operating in Orogastric Devices Market
The global orogastric Devices Market is highly fragmented, with the presence of various key players. A large number of manufacturers hold a major share in their respective regions.
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Surgical Masks Market North America dominated the global surgical masks market in 2020 and the trend is projected to continue during the forecast period. This can be ascribed to rapidly increasing number of COVID-19 cases in the U.S. and government & regulatory policies regarding manufacture as well as import of surgical masks.
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Petroleum jelly market expected to reach US$ 716.9 Mn by 2031
Petroleum Jelly Market: Introduction
Transparency Market Research delivers key insights on the global petroleum jelly market. In terms of value, the global petroleum jelly market is expected to expand at a CAGR of 4.26% during the forecast period, owing to numerous factors regarding which TMR offers thorough insights and forecasts in its report on the global petroleum jelly market.
Petroleum jelly is used in the treatment of epistaxis. It is also used in skin care and hair care products. Petroleum jelly is also used in hair pomades, which keep the hair shiny. In industrial appliances, petroleum jelly is used as an anticorrosion coat on metallic trinkets, non-stainless steel blades, and gun barrels. Petroleum jelly can be used as a finishing coat on wood and smooth leather products, owing to its water repellent properties. In industrial production processes, petroleum jelly is utilized as a release agent for plaster molds and castings. It can also be used as a waterproofing cream in the leather industry. Furthermore, petroleum jelly is utilized as a tack reducer additive in paper printing inks.
Petroleum Jelly Market: Dynamics
Petroleum jelly can be used in various applications that serve the purpose of metal protection as well as lubrication for machinery used in food preparation. Thus, petroleum jelly enhances food production standards. Petroleum jelly can be used as a release agent for plaster molds and castings. It can be used as a mold release agent for simple molds without fine details. The jelly can be directly applied by the hand. Thus, petroleum jelly can be a cost effective alternative to other traditional mold release agents.
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Petroleum jelly can be used as a battery terminal compound. It protects battery terminals from corrosion when applied on the cable clamps and battery terminals. The hydrophobic nature of petroleum jelly enables it to act as a barrier to moisture. It also keeps battery terminals free from dirt, thus helping retain battery in good condition. The emergence of electric vehicles to reduce the global carbon footprint and encouragement by governments in the form of incentives for the purchase of e-vehicles are anticipated to boost the demand for batteries, thus propelling the petroleum jelly market during the forecast period.
Petroleum Jelly Market: Prominent Regions
North America is a key region of the global petroleum jelly market. The U.S. held large share of the petroleum jelly market in North America in 2020. The growth of the market in the country can be ascribed to the expansion of the cosmetic industry. The increase in the use of personal care and skincare products in the U.S. is driving cosmetics industry. According to the Forbes magazine, the U.S. was the world’s largest beauty market in 2020.
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Women in the U.S. spend around US$ 3,756 on cosmetics annually. Petroleum jelly is a vital ingredient used in the manufacture of skincare, personal care and hair care products. Petroleum jelly keeps the skin hydrated and enhances its health. Thus, the rise in the demand for cosmetics products is expected to boost the consumption of petroleum jelly.
The rapid growth of the petroleum jelly market in Europe is driven by the expansion of the electronic vehicles market. The implementation of stringent regulations on reduction of carbon footprint has driven the purchase of electronic vehicles. Electronic vehicles use batteries to store energy. This helps eliminate the need of traditional gasoline fuel, thus eliminating the emission of hydrocarbons. As battery terminal compound, petroleum jelly protects battery terminals from corrosion, dirt, and moisture, thus increasing the service life of batteries.
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Harsh weather conditions in Europe are driving the demand for skincare products. Petroleum jelly helps retains the moisture in the skin, thus protecting the skin from becoming dry. Thus, rise in usage of petroleum jelly as a moisturizing agent and battery terminal compound is anticipated to boost the demand for petroleum jelly in the region.
The increase in demand for petroleum jelly in Asia Pacific can be ascribed to the rise in consumption of petroleum jelly as a cable filling compound in the region. Petroleum jelly is used as cable filling compound in fiber optic cables as well as traditional copper cables. It eliminates the formation of moisture in the cables, thus improving their service life. According to the IBEF (Indian Brand Equity Foundation), in the 2021-2022 Union Budget, the Government of India allocated US$ 1.9 Bn for the development of telecom infrastructure, which includes completion of optical fiber cable-based network for defense services. Thus, increase in investment in the telecom infrastructure in Asia Pacific is anticipated to boost the petroleum jelly market in the region during the forecast period.
Petroleum Jelly Market: Key Players
Key players operating in the global petroleum jelly market are Royal Dutch Shell, Sonneborn LLC, Sasol, Raj Petro Specialities Pvt. Ltd., Eastern Petroleum, Eastern Petroleum, Sovereign Chemicals & Cosmetics, Unisynth Group, Shimi Taghtiran Co., Nippon Siero Co., Ltd., and Petrobras.
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Haemophilia Market is projected to display CAGR of 6.84% during 2018 -2023
According to ACQUIRE MARKET RESEARCH Analytics research report “Global Haemophilia Market - Analysis By Type (Haemophilia A, Haemophilia B), By Treatment (On-demand, Prophylaxis), By Region, By Country (2019 Edition): Opportunities and Forecasts (2013-2023) By Region (North America, Europe, Asia-Pacific, Rest of the World), By Country (U.S, Canada, Germany, United Kingdom, Japan, China, India, Brazil)” , the global Haemophilia market is projected to display a modest growth represented by a CAGR of 6.84% during 2018 -2023.
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A comprehensive research report created through extensive primary research (inputs from industry experts, companies, stakeholders) and secondary research, the report aims to present the analysis of Global Haemophilia Market. The market of Global Haemophilia has been analyzed By Type (Haemophilia A, Haemophilia B), By Treatment (On-demand, Prophylaxis), By Region (North America, Europe, Asia Pacific, Rest of the world) and By Country (U.S, Canada, Germany, U.K, Japan, China, India and Brazil). The Global Haemophilia market has been assessed for the historical period of 2013-2017 and the forecast period of 2018-2023.
Over the recent years, global haemophilia market has been witnessing growth, on account of several driving factors including increasing life expectancy of hemophiliac patients, reduction in inhibitor formation in severe haemophilia cases and new emerging therapies for treatment of haemophilia. Moreover, increasing per capita healthcare expenditure and growing incidences of hemorrhages, arthropaedic and dental surgeries, epistaxis, laceration and abrasion is expected to propel the demand for haemophilia market. In this research report, the market is segmented on the basis of type and treatment. By type, the segment of haemophilia A is predicted to hold its dominant position in the market. Amongst the regions, North America accounts for the largest regional share in the global endoscopy devices market in 2018. However, Asia Pacific is predicted to advance at the highest rate. Presence of vast consumer base, particularly in emerging nations such as China and India, in addition to growing per capita expenditure on healthcare is likely to drive the regional market.
The report titled “Global Haemophilia Market, By Type (Haemophilia A, Haemophilia B), By Treatment (On-demand, Prophylaxis), By Region, By Country (2019 Edition): Opportunities and Forecasts (2013-2023) By Region (North America, Europe, Asia-Pacific, Rest of the World), By Country (U.S, Canada, Germany, United Kingdom, Japan, China, India, Brazil)”| has covered and analyzed the potential of global haemophilia market and provides statistics and information on market size, shares and growth factors. The report intends to provide cutting-edge market intelligence and help decision makers take sound investment evaluation. Besides, the report also identifies and analyses the emerging trends along with major drivers, challenges and opportunities in the global haemophilia market. Additionally, the report also highlights market entry strategies for various companies across the globe.
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Scope of the Report
Global Haemophilia Market (Actual Period: 2013-2017, Forecast Period: 2018-2023)
Haemophilia Market Size, Growth, Forecast
By Type Haemophilia A, Haemophilia B
By Treatment On- demand, Prophylaxis
Regional Markets North America, Europe, Asia-Pacific, ROW (Actual Period: 2013-2017, Forecast Period: 2018-2023)
Haemophilia Market Size, Growth, Forecast
By Type Haemophilia A, Haemophilia B
By Treatment On- demand, Prophylaxis
Country Analysis U.S., Canada, Germany, U.K, Japan, India, China, Brazil (Actual Period: 2013-2017, Forecast Period: 2018-2023)
Haemophilia Market Size, Growth, Forecast
By Type Haemophilia A, Haemophilia B
By Treatment On- demand, Prophylaxis
Other Report Highlights
Market Dynamics Drivers and Restraints
Market Trends
Company Share Analysis
SWOT Analysis
Porter Five Force Analysis
Supply Chain Analysis
Competitive Landscape
Policy and Regulatory Landscape
Company Analysis Bayer, Novo Nordisk, Pfizer, Roche, Aptevo Therapeutics, Catalyst Bio Sciences, Dimension Therapeutics, Shire, CSL Behring, Alnylam Pharmaceuticals .
Customization of the Report
The report could be customized according to the client’s specific research requirements. No additional cost will be required to pay for limited additional research.
Table of Contents
1. Research Methodology
2. Executive Summary
3. Strategic Recommendations
4. Haemophilia Outlook
5. Global Haemophilia Market: Growth and Forecast
5.1 By Value (2013-2017)
5.2 By Value (2018-2023)
6. Global Haemophilia Market: Segment Analysis
6.1 Global Haemophilia Market Size, By Type: Breakdown (%)
6.1.1 Global Haemophilia Market Size, By Type, 2017 (%)
6.1.2 Global Haemophilia Market Size, By Type, 2023 (%)
6.2 Global Haemophilia A Market, By Value (2013-2023)
6.3 Global Haemophilia B Market, By Value (2013-2023)
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caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings
Drug Online
caduet Generic drug of the Therapeutic class: Cardiology and angiology Active ingredients: Amlodipine , Atorvastatin
what is caduet medication?
This medication is supplied as blue, oval-shaped, film-coated tablets debossed with “Pfizer” on one side and “CDT 101” on the other side.
Boxes of 7, 10, 14, 20, 28, 30, 50, 56, 60, 90, 100 or 200 tablets.
Not all presentations may be marketed.
what is caduet medication used for and indication?
CADUET is indicated for the prevention of cardiovascular events in hypertensive patients with 3 associated cardiovascular risk factors, with normal to moderately elevated cholesterol without established coronary artery disease, and in whom, according to current recommendations, the concomitant use of amlodipine and a low dose of atorvastatin is suitable .
CADUET should be used when the response to regimen and other non-pharmacological measures is inadequate.
caduet dosage
Oral route
The usual starting dose is 5 mg / 10 mg once daily.
If tighter blood pressure control is required, a dosage of 10 mg / 10 mg once daily may be administered.
The tablets can be taken at any time of the day, with or without food.
CADUET can be used alone or in combination with other antihypertensive drugs, but it must not be used in combination with other calcium channel blockers or another statin.
The combination of CADUET and fibrates should generally be avoided (see sections 4.4 and Interactions with other medicinal products and other forms of interaction ).
Patients with renal impairment : No dosage adjustment is necessary in patients with impaired renal function (see sections 4.4 and Pharmacokinetic properties ).
Patients with hepatic impairment : CADUET is contraindicated in patients with active hepatic disease.
Children / Adolescents : The safety and efficacy of CADUET have not been established in children / adolescents. Therefore, the use of CADUET is not recommended in this population.
Elderly : It does not appear necessary to adjust the dose in the elderly (see section Pharmacokinetic properties ).
Combination with other medicinal products : In combination with ciclosporin, the dose of atorvastatin should not exceed 10 mg (see section Interactions with other medicinal products and other forms of interaction ).
Contraindications
CADUET is contraindicated in patients:
Being hypersensitive to dihydropyridines *, to amlodipine, to atorvastatin or to any of the excipients of this medicine,
have active liver disease or a persistent and unexplained increase in serum transaminases exceeding 3 times the upper limit of normal,
In women who are pregnant, breastfeeding or of childbearing potential and not using reliable contraceptive methods (see section Pregnancy and breast-feeding ),
In combination with itraconazole, ketoconazole, telithromycin (see section Interactions with other medicinal products and other forms of interactions ),
having severe hypotension,
Having shock (including cardiogenic shock),
Having an obstruction of the efferent pathway to the left ventricle (for example severe aortic stenosis),
With haemodynamically unstable heart failure after acute myocardial infarction.
* amlodipine is a calcium channel blocker derived from dihydropyridine.
HOW TO TAKE CADUET?
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if in doubt.
Adults
The recommended starting dose of CADUET is one 5 mg / 10 mg tablet per day. Your doctor may increase the dose if necessary to 1 tablet of CADUET 10 mg / 10 mg per day.
The tablets should be swallowed whole with a glass of water. They can be taken at any time of the day, with or without food. However, it is best to take them at the same time each day.
Continue to follow your doctor’s dietary advice, especially to eat a low fat diet, avoid tobacco, and exercise regularly.
If you have the impression that the effect of CADUET tablets is too strong or too weak, talk to your doctor or pharmacist.
Use in children and adolescents
This medication is not recommended for children and adolescents.
If you take more CADUET 10 mg / 10 mg film-coated tablets than you should
If you accidentally take too many CADUET tablets (more than your usual dose), ask your doctor or the nearest hospital for advice. Take any remaining tablets, the carton or the whole carton with you so that hospital staff can quickly identify which medicine you have taken.
If you forget to take CADUET 10 mg / 10 mg film-coated tablets
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
If you stop taking CADUET 10 mg / 10 mg film-coated tablets
Do not stop taking CADUET unless your doctor tells you to.
If you have any further questions on the use of this medicine or want to stop taking your treatment, ask your doctor or pharmacist for more information.
How To Store Caduet?
Keep this medication out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister, the carton and the vial after “EXP”. The expiration date refers to the last day of that month.
Store at a temperature not exceeding 30 ° C.
Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.
caduet side effects
The safety of CADUET has been evaluated in double-blind, placebo-controlled studies in 1092 patients treated for concomitant hypertension and dyslipidemia. During clinical trials with CADUET, no specific adverse events specific to this combination were observed.
Adverse events were limited to those previously reported for amlodipine and / or atorvastatin (see table of adverse events below).
In controlled clinical trials, discontinuation of treatment due to clinical adverse events or laboratory abnormalities was observed in 5.1% of patients treated with amlodipine and atorvastatin versus 4.0% of patients treated with amlodipine and atorvastatin. patients taking a placebo.
The adverse events below, listed according to MedDRA system organ classification and frequency order, relate to amlodipine and atorvastatin individually.
Very common: ³ 1/10, common: ³ 1/100 and <1/10, infrequent: ³ 1/1000 and <1/100, rare: ³ 1/10000 and <1/1000, very rare: < 1 / 10,000, frequency not known (cannot be estimated from the available data).
MedDRA
System organ classes
Side effects
Frequency
Amlodipine
Atorvastatin
Infections and infestations
Nasopharyngitis
–
Frequent
Blood and lymphatic system disorders
Leukopenia
Very rare
–
Thrombocytopenia
Very rare
Rare
Immune system disorders
hypersensitivity
Very rare
Frequent
Anaphylaxis
–
Very rare
Metabolism and nutrition disorders
Hyperglycemia *
Very rare
Frequent
Weight gain
Infrequent
Infrequent
Weightloss
Infrequent
–
Hypoglycemia
–
Infrequent
Anorexia
–
Infrequent
Psychiatric disorders
Insomnia
Infrequent
Infrequent
Mood disorders (including anxiety)
Infrequent
–
Nightmares
–
Infrequent
Depression
Infrequent
Frequency not known
Confusion
Rare
–
Disorders of the system nervous
Drowsiness
Frequent
–
Dizziness
Frequent
Infrequent
Headache (especially at the start of treatment)
Frequent
Frequent
Tremors
Infrequent
–
Hypoesthesias, paresthesias
Infrequent
Infrequent
Syncope
Infrequent
Hypertonia
Very rare
–
Peripheral neuropathy
Very rare
Rare
Amnesia
–
Infrequent
Dysgeusia
Infrequent
Infrequent
Extrapyramidal syndrome
Frequency not known
–
Eye disorders
Blurred vision
–
Infrequent
Visual disturbances (including diplopia)
Infrequent
Rare
Ear and labyrinth disease
Tinnitus
Infrequent
Infrequent
Hearing loss
–
Very rare
Cardiac disorders
Palpitations
Frequent
–
Angina pectoris
Rare
–
Myocardial infarction
Very rare
–
Arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation)
Very rare
–
Vascular disorders
Flushing
Frequent
–
Hypotension
Infrequent
–
Vasculitis
Very rare
–
Respiratory, thoracic and mediastinal disorders
Pharyngolaryngeal pain
–
Frequent
Epistaxis
–
Frequent
Dyspnea
Infrequent
–
Rhinitis
Infrequent
–
Cough
Very rare
–
Interstitial lung disease, especially during long-term treatment
Frequency not known
Gastrointestinal disorders
Gingival hyperplasia
Very rare
–
Nausea
Frequent
Frequent
Upper and lower abdominal pain
Frequent
Infrequent
Vomiting
Infrequent
Infrequent
Dyspepsia
Infrequent
Frequent
Changes in intestinal transit (including diarrhea and constipation)
Infrequent
–
Dry mouth
Infrequent
–
Dysgeusia
Infrequent
–
Diarrhea, constipation, gas
–
Frequent
Gastritis
Very rare
–
Pancreatitis
Very rare
Infrequent
Eructation
–
Infrequent
Hepatobiliary disorders
Hepatitis
Very rare
Infrequent
Cholestasis
–
Rare
Jaundice
Very rare
–
Hepatic insufficiency
–
Very rare
Skin and subcutaneous tissue disorders
Bullous dermatosis including erythema multiforme
Very rare
Rare
Angioedema
Very rare
–
Erythema multiforme
Very rare
–
Alopecia
Infrequent
Infrequent
Purpura
Infrequent
–
Skin discoloration
Infrequent
–
Pruritus
Infrequent
Infrequent
Eruption
Infrequent
Infrequent
Hyperhidrosis
Infrequent
–
Exanthema
Infrequent
–
Urticaria
Very rare
Infrequent
Angioneurotic edema
Very rare
Rare
Exfoliative dermatitis
Very rare
–
Photosensitivity
Very rare
–
Stevens-Johnson syndrome
Very rare
Rare
Bullous erythroderma with epidermolysis
–
Rare
Musculoskeletal and connective tissue disorders
Swelling of the joints (including swelling of the ankles)
Frequent
Frequent
Arthralgia, myalgia
(see section Warnings and precautions for use )
Infrequent
Frequent
Muscle cramps, muscle spasms
Infrequent
Frequent
Back pain
Infrequent
Frequent
Neck pain
–
Infrequent
Pain in extremity
–
Frequent
Muscle fatigue
–
Infrequent
Myositis (see section Warnings and precautions for use )
–
Rare
Rhabdomyolysis, myopathy
(see section Warnings and precautions for use )
–
Rare
Tendinopathies, in rare cases tendon rupture
–
Rare
Immune-mediated necrotizing myopathy
–
Frequency not known
Kidney and urinary tract disorders
Urination disorder, nocturia, pollakiuria
Infrequent
–
Reproductive system and breast disorders
Incapacity
Infrequent
Infrequent
Gynecomastia
Infrequent
Very rare
General disorders and administration site conditions
Edema
Frequent
Infrequent
Peripheral edema
–
Infrequent
Tired
Frequent
Infrequent
Chest pain
Infrequent
Infrequent
Asthenia
Infrequent
Infrequent
Pain
Infrequent
–
Discomfort
Infrequent
Infrequent
Fever
–
Infrequent
Investigations
Increased liver enzymes: alanine aminotransferase, aspartate aminotransferase (mainly related to cholestasis)
Very rare
Frequent
Blood CK increased (see section 4.4 )
–
Frequent
Leukocyturia
–
Infrequent
* Diabetes: The frequency depends on the presence or absence of risk factors (fasting blood sugar ³ 5.6 mmol / l, BMI> 30 kg / m², increased triglyceride levels, history of high blood pressure).
caduet Interactions
Taking other medications
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets. This interaction may cause one or both of the medicines to be less effective, or on the contrary, this interaction may increase the risk or severity of side effects, including major muscle disorders known as rhabdomyolysis and myopathy (see section 4). .
Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets:
certain antibiotics such as rifampicin or certain “macrolide” antibiotics such as erythromycin, clarithromycin, telithromycin, fusidic acid or certain drugs used to treat infections caused by fungi such as ketoconazole, itraconazole,
medicines used to regulate lipid levels: fibrates, such as gemfibrozil or colestipol,
medicines used to regulate your heart rhythm, such as amiodarone, diltiazem and verapamil,
medicines used to treat or prevent seizures such as carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone,
medicines used to change how your immune system works, such as cyclosporin
protease inhibitors such as ritonavir, indinavir, nelfinavir used in the treatment of HIV,
medicines used to treat depression, such as nefazodone and imipramine,
medicines used to treat mental disorders, such as neuroleptics,
medicines used to treat heart failure, such as beta blockers
medicines used to treat high blood pressure, such as angiotensin II inhibitors, converting enzyme inhibitors, verapamil and diuretics,
alpha blockers used to treat high blood pressure or prostate problems
other medicines known to interact with CADUET 10 mg / 10 mg film-coated tablets such as ezetimibe (which lowers cholesterol), warfarin (which decreases blood clotting), oral contraceptives, stiripentol (an anticonvulsant used for treatment of epilepsy), cimetidine (used for heartburn and stomach ulcers), phenazone (a pain reliever), antacids (containing aluminum or magnesium, used to relieve problems stomach), and amifostine (used to treat cancer),
sildenafil (used in the treatment of erectile dysfunction, impotence),
dantrolene and baclofen (muscle relaxants),
steroids,
over-the-counter St. John’s Wort products.
CADUET may lower your blood pressure further if you are already taking other medicines to treat your high blood pressure.
If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, talk to your doctor or pharmacist.
INTERACTIONS OF CADUET 10 MG / 10 MG WITH FOOD AND DRINK
Food and drinks
CADUET 10 mg / 10 mg film-coated tablets can be taken at any time of the day, with or without food.
Grapefruit juice
Do not take more than one or two glasses of grapefruit juice per day as large amounts of grapefruit juice may affect the effects of CADUET 10 mg / 10 mg film-coated tablets.
Alcohol
Avoid drinking too much alcohol while taking CADUET 10 mg / 10 mg film-coated tablets. See also section 2 “Take special care with CADUET 10 mg / 10 mg film-coated tablets” for more details.
Drive and use machines
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Warnings and Precautions
Heart failure
Liver function monitoring
Clinical signs of hepatic dysfunction
Increased transaminases
Heavy alcohol consumption
Hepatic insufficiency
History of liver disease
Predisposing factor to the occurrence of rhabdomyolysis
Subject over 70 years of age
Unexplained muscle pain
Muscle cramp
Muscular weakness
Increase in CPK
Rhabdomyolysis
History of hemorrhagic stroke
History of lacunar infarction
Interstitial lung disease
Risk of diabetes
Woman of childbearing age
Heart failure
Patients with heart failure should be treated with caution. In a long-term placebo-controlled study in patients with severe heart failure (NYHA class III and IV), the reported incidence of pulmonary edema was higher in the amlodipine group compared to the placebo group. (see section Pharmacodynamic properties). Calcium channel blockers including amlodipine should be used with caution in patients with congestive heart failure because they may increase the risk of cardiovascular events and mortality.
Liver effects
Liver function tests should be performed before the start of treatment and then regularly after initiation of treatment, as well as in the event of signs or symptoms suggestive of liver damage. In the event of elevation of the serum transaminase level, monitoring is necessary until normalization.
A persistent increase in ALT or AST exceeding 3 times the upper limit of normal (ULN), should lead to discontinuation of treatment.
The half-life of amlodipine is increased and its AUC (Area Under the Curve) is greater in patients with hepatic impairment; dosage recommendations have not been established.
Due to the presence of atorvastatin, CADUET should be used with caution in patients who consume large amounts of alcohol, in patients with hepatic impairment and / or a history of liver disease.
Muscle effects
Like other HMG-CoA reductase inhibitors, atorvastatin can affect skeletal muscles and lead to myalgia, myositis and myopathies. These muscle damage may rarely progress to rhabdomyolysis, characterized by high levels of creatine kinase (CK) (more than 10 times the ULN), myoglobinemia and myoglobinuria which can lead to kidney failure, and in some cases be fatal.
Regular testing of CK or other muscle enzymes is not recommended in asymptomatic patients treated with statins. However, dosing of CKs is recommended before initiating statin therapy in patients with predisposing factors to rhabdomyolysis as well as in those with muscle symptoms during statin therapy (see below).
Very rare cases of autoimmune-mediated necrotizing myopathies (IMNM) have been reported during or after treatment with certain statins. IMNM is clinically characterized by proximal muscle weakness and increased serum creatine kinase, which persist despite discontinuation of statin therapy.
Before initiation of treatment
CADUET should be prescribed with caution in patients with predisposing factors to rhabdomyolysis. Before starting treatment with a statin, creatine kinase (CK) levels should be checked in the following situations:
Renal failure.
Hypothyroidism.
Personal or family history of genetic muscle diseases.
Personal history of muscle toxicity during treatment with a statin or a fibrate.
History of liver disease and / or excessive alcohol consumption.
In elderly patients (> 70 years), the need for these measures should be assessed, depending on the presence of other factors predisposing to rhabdomyolysis.
Situations in which increased plasma concentrations may occur, due to interactions (see section 4.5) and use in special populations including genetic polymorphisms (see section 5.2). ).
In these situations, a regular reassessment of the benefit / risk of the treatment, as well as regular clinical monitoring is recommended.
If the initial CK level is significantly elevated (more than 5 times the ULN) treatment should not be started.
Creatine kinase measurement
Creatine kinase (CK) should not be measured after heavy exercise or in the presence of another possible cause of increased CK, as this will make interpretation of the results difficult. In the event of a significant elevation of CK (more than 5 times the ULN) before treatment, this should be systematically checked again within 5 to 7 days to confirm the results.
During treatment
It is recommended that patients be asked to promptly report any unexplained muscle pain, muscle cramps or weakness, particularly if accompanied by malaise or fever.
· If symptoms appear when a patient is under treatment with CADUET, a CK levels should be measured; if the CK level is significantly elevated (more than 5 times the ULN), treatment should be discontinued.
· If muscular symptoms are severe and cause daily discomfort, discontinuation of treatment should be considered, even if CK levels did not exceed 5 times the ULN.
· If symptoms resolve and CK levels return to normal, the reintroduction of CADUET may be considered at the lowest dose and under close supervision.
Treatment with CADUET should be discontinued in the event of a clinically significant increase in CK level (> 10 times the ULN) or if rhabdomyolysis is diagnosed or suspected.
Amlodipine has no effect on laboratory parameters.
Combinations with other drugs
As with other statins, the risk of rhabdomyolysis is increased when CADUET is administered in combination with certain drugs which may increase the plasma concentration of atorvastatin, such as strong inhibitors of CYP3A4 or protein transporters (eg, cyclosporin, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole, determovir and HIV protease inhibitors including ritonavir, lopinavir, atazanavir, indinavir, darunavir, tipranavir, etc / ritonavir). The risk of myopathy may also be increased in combination with gemfibrozil and other fibrates, antivirals used in the treatment of hepatitis C (HCV) (boceprevir, telaprevir, elbasvir / grazoprevir), erythromycin, niacin, l ‘ ezetimibe or colchicine. Therapeutic alternatives (not exhibiting these interactions) should be considered as far as possible.
In the event that the combination of these medicinal products with CADUET is necessary, the benefit / risk of concomitant treatments should be carefully assessed and appropriate clinical monitoring is recommended (see section Interactions with other medicinal products and other forms of interactions).
CADUET should not be administered simultaneously with fusidic acid in systemic form, and for up to 7 days after stopping treatment with fusidic acid. In patients where the use of systemic fusidic acid is considered essential, statin therapy should be discontinued for the duration of fusidic acid therapy. Cases of rhabdomyolysis (some fatal) have been reported in patients receiving fusidic acid and a statin in combination (see section Interactions with other medicinal products and other forms of interactions). Patients should be informed of the need to seek immediate medical attention if they experience symptoms of muscle weakness, pain, or muscle tenderness.
Statin therapy can be restarted seven days after the last dose of fusidic acid.
In exceptional circumstances, when prolonged treatment with systemic fusidic acid is required, e.g. for the treatment of severe infections, the need for co-administration of CADUET and fusidic acid should only be considered in cases of per case and under close medical supervision.
Prevention of stroke by aggressively lowering cholesterol levels (SPARCL study)
In a posteriori analysis performed in subgroups of patients with recent stroke or transient ischemic attack (TIA) but without coronary artery disease, a higher frequency of hemorrhagic stroke was observed in treated patients. per 80 mg atorvastatin compared to patients on placebo.
This high risk is particularly observed in patients who have already had a hemorrhagic stroke or a lacunar infarction at the inclusion of the study.
In patients with a history of hemorrhagic stroke or lacunar infarction, the benefit / risk balance of atorvastatin 80 mg is uncertain. Therefore, the potential risk of occurrence of haemorrhagic stroke should be carefully assessed before any initiation of treatment (see section Pharmacodynamic properties).
Interstitial lung disease
Cases of interstitial lung disease have exceptionally been reported with certain statins, particularly during long-term therapy .
Symptoms may include dyspnea, a non-productive cough, and altered general condition (fatigue, weight loss, and fever). If interstitial lung disease is suspected in a patient, statin therapy should be discontinued.
Diabetes
There is some evidence that statins, as a pharmacological class, increase blood sugar. In some patients at high risk of developing diabetes, statins may cause hyperglycaemia requiring the initiation of diabetes treatment. This risk is nevertheless compensated by the reduction in the vascular risk under statins and therefore it should not be a reason for stopping statins. Patients at risk (fasting blood glucose between 5.6 and 6.9 mmol / l, BMI> 30 kg / m², increased triglyceride levels, arterial hypertension) should be monitored clinically and biologically in accordance with national recommendations.
PREGNANCY & BREAST-FEEDING & FERTILITY
Caduet is contraindicated during pregnancy and lactation.
Women of childbearing age
Women of childbearing potential should use reliable contraceptive measures during treatment ( see Contraindications ).
Pregnancy
The safety of atorvastatin has not been established in pregnant women. No controlled clinical trials have been performed in pregnant women treated with atorvastatin. Following intrauterine exposure to HMG-CoA reductase inhibitors, birth defects have rarely been reported. Studies in animals have shown reproductive toxicity ( see Preclinical safety ).
Treatment of the mother with atorvastatin may reduce the fetal level of mevalonate, which is a precursor of cholesterol biosynthesis. Atherosclerosis is a chronic process, and stopping a lipid-lowering drug during pregnancy should generally have little effect on the long-term risk associated with primary hypercholesterolemia.
For these reasons, Caduet should not be used during pregnancy, or in a woman planning to become pregnant or in whom pregnancy is suspected. Caduet treatment should be withheld during pregnancy or until it has been determined that the woman is not pregnant ( see Contraindications ).
If pregnancy is discovered during treatment, it should be stopped immediately.
Feeding with milk
Amlodipine is excreted in breast milk. The proportion of maternal dose received by the infant has been estimated at an interquartile range of 3-7%, with a maximum of 15%. The effect of amlodipine on infants is unknown. The excretion of atorvastatin or its metabolites in human milk is not known. In rats, the plasma concentrations of atorvastatin and its metabolites are similar to those found in milk ( see Preclinical safety ). Due to the possibility of serious side effects, women treated with Caduet should not breast-feed their infants ( see Contraindications ). Atorvastatin is contraindicated during breastfeeding ( see Contraindications ).
Fertility
No effect of atorvastatin on fertility has been demonstrated in studies conducted in male or female animals ( see Preclinical Safety ).
Reversible biochemical changes in the sperm head have been reported in some patients treated with calcium channel blockers. There is insufficient clinical data regarding the potential effect of amlodipine on fertility. In a study carried out in rats, adverse effects were detected on male fertility ( see Preclinical safety ).
What happens if I overdose from Caduet?
No information is available regarding overdose of Caduet in humans.
Amlodipine:
For amlodipine, experience with intentional overdose in humans is limited. Massive overdose could cause extensive peripheral vasodilation and possibly reflex tachycardia. Marked and possibly prolonged systemic hypotension up to and including shock with fatal outcome has been reported. Any hypotension resulting from acute intoxication requires monitoring in an intensive cardiological care unit. A vasoconstrictor can be used to restore vascular tone and blood pressure. Since amlodipine is highly protein bound, dialysis is unlikely to provide any benefit.
Atorvastatin:
There is no specific treatment for atorvastatin overdose. In the event of overdose, the patient should receive symptomatic treatment and supportive measures should be implemented as needed. Liver function and serum CK concentrations should be monitored. Due to the strong binding of the drug to plasma proteins, hemodialysis is not expected to significantly increase the clearance of atorvastatin.
What should I do if I miss a dose?
If you forget to take CADUET 5/ 10 mg -5/ 10 mg film-coated tablets:
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
What is Forms and Composition ?
SHAPES and PRESENTATIONS
5 mg / 10 mg film-coated tablet (oval, debossed with “Pfizer” on one side and “CDT 051” on the other side; white) and 10 mg / 10 mg (oval, debossed with “Pfizer “On one side and” CDT 101 “on the other side; blue): Boxes of 30 and 90, in blisters.
COMPOSITION
p cpAmlodipine (INN) as amlodipine besilate5 mgor10 mgAtorvastatin (INN) as atorvastatin calcium trihydrate10 mg
Excipients (common): Core: calcium carbonate, croscarmellose sodium, microcrystalline cellulose, pregelatinized corn starch, polysorbate 80, hydroxypropylcellulose, colloidal anhydrous silica, magnesium stearate. Film- coating : 5 mg / 10 mg tablet: Opadry II white 85F28751 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc). 10 mg / 10 mg tablet: Opadry II blue 85F10919 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc, indigo carmine aluminum lake E132).
NOT’s
Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:
general information:
Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles
Additional information:
General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.
Special warnings:
For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.
Side effects:
It treats possible side effects and drug interactions that require attention and its effect on continuous use.
The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
The post caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings appeared first on Drug Online.
from Drug Online https://bit.ly/3lxi9nO via Edrug Online from Faculty of Medicine https://bit.ly/3hIQsGt via Internal Medicine
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Epistaxis Market to Explore Emerging Trends of Coming Years
Epistaxis is a condition that results in uncertain nose bleeding from either of the nostrils. This clinical condition is usually classified as anterior epistaxis and posterior epistaxis based on the site where the bleeding originates. Epistaxis is rarely life threatening unless it is associated with chronic disorders such as cancer. About 10% of nosebleeds is life threatening, and it is accounted that four of the 2.4 million deaths occur due to epistaxis. This condition commonly occurs in younger children (2-10 years) and older people (50-80 years); however, it is more common among individuals who are above 50 years of age. Prevalence is higher in males (58%) as compared to females (42%). It is usually caused by local trauma, including nasal infection and even nose picking. Environmental factors causing epistaxis include dry climate, lack of humidity in the atmosphere, or prolong inhalation of dry air. People who are on medications such as warfarin, clopidogrel, aspirin, or any other anticoagulant medications are more susceptible to epistaxis. Other predisposing factors such as infection, allergic and non-allergic rhinitis, cocaine snorting, hypertension, alcohol abuse, and inherited bleeding problems also lead to epistaxis.
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In terms of treatment, the global epistaxis market is segmented as topical vasoconstrictors, antibiotic ointments (mupirocin), anesthetics, and nasal cautery. The topical vasoconstrictors segment includes oxymetazoline, co-phenylcaine, or adrenaline, which are applied directly to the mucous membrane. The anesthetics segment includes lidocaine or lignocaine and is often given in combination with vasoconstrictors. Nasal cautery is the most common treatment of epistaxis. Chemical cautery (silver nitrate) and electrocautery (an electrically charged wire such as platinum) are two types of nasal cautery. Chemical cautery is the most popular method for the treatment of idiopathic recurrent epistaxis. Most of the research is focused on device development, thus boosting the growth of the epistaxis market. In 2016, Smith & Nephew launched a range of epistaxis management devices using ‘rapid rhino technology’ that has a blend of carboxymethyl cellulose (CMC), which exhibit self-lubricating properties that provide gentle and even compression to the nasal area and helps in the quicker re-conformation of the nasal anatomy. Additionally, growing incidence rates of epistaxis and chronic diseases boost the growth of the global epistaxis market. The lifelong incidence rate of epistaxis among the general population is about 60%, of which only 10% seeks medical treatment. This factor is projected to restrain the growth of the market during the forecast period.
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Petroleum Jelly Market – Study On Applications 2031
Petroleum Jelly Market: Introduction
Transparency Market Research delivers key insights on the global petroleum jelly market. In terms of value, the global petroleum jelly market is expected to expand at a CAGR of 4.26% during the forecast period, owing to numerous factors regarding which TMR offers thorough insights and forecasts in its report on the global petroleum jelly market.
Petroleum jelly is used in the treatment of epistaxis. It is also used in skin care and hair care products. Petroleum jelly is also used in hair pomades, which keep the hair shiny. In industrial appliances, petroleum jelly is used as an anticorrosion coat on metallic trinkets, non-stainless steel blades, and gun barrels. Petroleum jelly can be used as a finishing coat on wood and smooth leather products, owing to its water repellent properties. In industrial production processes, petroleum jelly is utilized as a release agent for plaster molds and castings. It can also be used as a waterproofing cream in the leather industry. Furthermore, petroleum jelly is utilized as a tack reducer additive in paper printing inks.
Petroleum Jelly Market: Dynamics
Petroleum jelly can be used in various applications that serve the purpose of metal protection as well as lubrication for machinery used in food preparation. Thus, petroleum jelly enhances food production standards. Petroleum jelly can be used as a release agent for plaster molds and castings. It can be used as a mold release agent for simple molds without fine details. The jelly can be directly applied by the hand. Thus, petroleum jelly can be a cost effective alternative to other traditional mold release agents.
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Petroleum jelly can be used as a battery terminal compound. It protects battery terminals from corrosion when applied on the cable clamps and battery terminals. The hydrophobic nature of petroleum jelly enables it to act as a barrier to moisture. It also keeps battery terminals free from dirt, thus helping retain battery in good condition. The emergence of electric vehicles to reduce the global carbon footprint and encouragement by governments in the form of incentives for the purchase of e-vehicles are anticipated to boost the demand for batteries, thus propelling the petroleum jelly market during the forecast period.
Petroleum Jelly Market: Prominent Regions
North America is a key region of the global petroleum jelly market. The U.S. held large share of the petroleum jelly market in North America in 2020. The growth of the market in the country can be ascribed to the expansion of the cosmetic industry. The increase in the use of personal care and skincare products in the U.S. is driving cosmetics industry. According to the Forbes magazine, the U.S. was the world’s largest beauty market in 2020.
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Women in the U.S. spend around US$ 3,756 on cosmetics annually. Petroleum jelly is a vital ingredient used in the manufacture of skincare, personal care and hair care products. Petroleum jelly keeps the skin hydrated and enhances its health. Thus, the rise in the demand for cosmetics products is expected to boost the consumption of petroleum jelly.
The rapid growth of the petroleum jelly market in Europe is driven by the expansion of the electronic vehicles market. The implementation of stringent regulations on reduction of carbon footprint has driven the purchase of electronic vehicles. Electronic vehicles use batteries to store energy. This helps eliminate the need of traditional gasoline fuel, thus eliminating the emission of hydrocarbons. As battery terminal compound, petroleum jelly protects battery terminals from corrosion, dirt, and moisture, thus increasing the service life of batteries.
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Harsh weather conditions in Europe are driving the demand for skincare products. Petroleum jelly helps retains the moisture in the skin, thus protecting the skin from becoming dry. Thus, rise in usage of petroleum jelly as a moisturizing agent and battery terminal compound is anticipated to boost the demand for petroleum jelly in the region.
The increase in demand for petroleum jelly in Asia Pacific can be ascribed to the rise in consumption of petroleum jelly as a cable filling compound in the region. Petroleum jelly is used as cable filling compound in fiber optic cables as well as traditional copper cables. It eliminates the formation of moisture in the cables, thus improving their service life. According to the IBEF (Indian Brand Equity Foundation), in the 2021-2022 Union Budget, the Government of India allocated US$ 1.9 Bn for the development of telecom infrastructure, which includes completion of optical fiber cable-based network for defense services. Thus, increase in investment in the telecom infrastructure in Asia Pacific is anticipated to boost the petroleum jelly market in the region during the forecast period.
Petroleum Jelly Market: Key Players
Key players operating in the global petroleum jelly market are Royal Dutch Shell, Sonneborn LLC, Sasol, Raj Petro Specialities Pvt. Ltd., Eastern Petroleum, Eastern Petroleum, Sovereign Chemicals & Cosmetics, Unisynth Group, Shimi Taghtiran Co., Nippon Siero Co., Ltd., and Petrobras.
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caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings
Drug Online
caduet Generic drug of the Therapeutic class: Cardiology and angiology Active ingredients: Amlodipine , Atorvastatin
what is caduet medication?
This medication is supplied as blue, oval-shaped, film-coated tablets debossed with “Pfizer” on one side and “CDT 101” on the other side.
Boxes of 7, 10, 14, 20, 28, 30, 50, 56, 60, 90, 100 or 200 tablets.
Not all presentations may be marketed.
what is caduet medication used for and indication?
CADUET is indicated for the prevention of cardiovascular events in hypertensive patients with 3 associated cardiovascular risk factors, with normal to moderately elevated cholesterol without established coronary artery disease, and in whom, according to current recommendations, the concomitant use of amlodipine and a low dose of atorvastatin is suitable .
CADUET should be used when the response to regimen and other non-pharmacological measures is inadequate.
caduet dosage
Oral route
The usual starting dose is 5 mg / 10 mg once daily.
If tighter blood pressure control is required, a dosage of 10 mg / 10 mg once daily may be administered.
The tablets can be taken at any time of the day, with or without food.
CADUET can be used alone or in combination with other antihypertensive drugs, but it must not be used in combination with other calcium channel blockers or another statin.
The combination of CADUET and fibrates should generally be avoided (see sections 4.4 and Interactions with other medicinal products and other forms of interaction ).
Patients with renal impairment : No dosage adjustment is necessary in patients with impaired renal function (see sections 4.4 and Pharmacokinetic properties ).
Patients with hepatic impairment : CADUET is contraindicated in patients with active hepatic disease.
Children / Adolescents : The safety and efficacy of CADUET have not been established in children / adolescents. Therefore, the use of CADUET is not recommended in this population.
Elderly : It does not appear necessary to adjust the dose in the elderly (see section Pharmacokinetic properties ).
Combination with other medicinal products : In combination with ciclosporin, the dose of atorvastatin should not exceed 10 mg (see section Interactions with other medicinal products and other forms of interaction ).
Contraindications
CADUET is contraindicated in patients:
Being hypersensitive to dihydropyridines *, to amlodipine, to atorvastatin or to any of the excipients of this medicine,
have active liver disease or a persistent and unexplained increase in serum transaminases exceeding 3 times the upper limit of normal,
In women who are pregnant, breastfeeding or of childbearing potential and not using reliable contraceptive methods (see section Pregnancy and breast-feeding ),
In combination with itraconazole, ketoconazole, telithromycin (see section Interactions with other medicinal products and other forms of interactions ),
having severe hypotension,
Having shock (including cardiogenic shock),
Having an obstruction of the efferent pathway to the left ventricle (for example severe aortic stenosis),
With haemodynamically unstable heart failure after acute myocardial infarction.
* amlodipine is a calcium channel blocker derived from dihydropyridine.
HOW TO TAKE CADUET?
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if in doubt.
Adults
The recommended starting dose of CADUET is one 5 mg / 10 mg tablet per day. Your doctor may increase the dose if necessary to 1 tablet of CADUET 10 mg / 10 mg per day.
The tablets should be swallowed whole with a glass of water. They can be taken at any time of the day, with or without food. However, it is best to take them at the same time each day.
Continue to follow your doctor’s dietary advice, especially to eat a low fat diet, avoid tobacco, and exercise regularly.
If you have the impression that the effect of CADUET tablets is too strong or too weak, talk to your doctor or pharmacist.
Use in children and adolescents
This medication is not recommended for children and adolescents.
If you take more CADUET 10 mg / 10 mg film-coated tablets than you should
If you accidentally take too many CADUET tablets (more than your usual dose), ask your doctor or the nearest hospital for advice. Take any remaining tablets, the carton or the whole carton with you so that hospital staff can quickly identify which medicine you have taken.
If you forget to take CADUET 10 mg / 10 mg film-coated tablets
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
If you stop taking CADUET 10 mg / 10 mg film-coated tablets
Do not stop taking CADUET unless your doctor tells you to.
If you have any further questions on the use of this medicine or want to stop taking your treatment, ask your doctor or pharmacist for more information.
How To Store Caduet?
Keep this medication out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister, the carton and the vial after “EXP”. The expiration date refers to the last day of that month.
Store at a temperature not exceeding 30 ° C.
Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.
caduet side effects
The safety of CADUET has been evaluated in double-blind, placebo-controlled studies in 1092 patients treated for concomitant hypertension and dyslipidemia. During clinical trials with CADUET, no specific adverse events specific to this combination were observed.
Adverse events were limited to those previously reported for amlodipine and / or atorvastatin (see table of adverse events below).
In controlled clinical trials, discontinuation of treatment due to clinical adverse events or laboratory abnormalities was observed in 5.1% of patients treated with amlodipine and atorvastatin versus 4.0% of patients treated with amlodipine and atorvastatin. patients taking a placebo.
The adverse events below, listed according to MedDRA system organ classification and frequency order, relate to amlodipine and atorvastatin individually.
Very common: ³ 1/10, common: ³ 1/100 and <1/10, infrequent: ³ 1/1000 and <1/100, rare: ³ 1/10000 and <1/1000, very rare: < 1 / 10,000, frequency not known (cannot be estimated from the available data).
MedDRA
System organ classes
Side effects
Frequency
Amlodipine
Atorvastatin
Infections and infestations
Nasopharyngitis
–
Frequent
Blood and lymphatic system disorders
Leukopenia
Very rare
–
Thrombocytopenia
Very rare
Rare
Immune system disorders
hypersensitivity
Very rare
Frequent
Anaphylaxis
–
Very rare
Metabolism and nutrition disorders
Hyperglycemia *
Very rare
Frequent
Weight gain
Infrequent
Infrequent
Weightloss
Infrequent
–
Hypoglycemia
–
Infrequent
Anorexia
–
Infrequent
Psychiatric disorders
Insomnia
Infrequent
Infrequent
Mood disorders (including anxiety)
Infrequent
–
Nightmares
–
Infrequent
Depression
Infrequent
Frequency not known
Confusion
Rare
–
Disorders of the system nervous
Drowsiness
Frequent
–
Dizziness
Frequent
Infrequent
Headache (especially at the start of treatment)
Frequent
Frequent
Tremors
Infrequent
–
Hypoesthesias, paresthesias
Infrequent
Infrequent
Syncope
Infrequent
Hypertonia
Very rare
–
Peripheral neuropathy
Very rare
Rare
Amnesia
–
Infrequent
Dysgeusia
Infrequent
Infrequent
Extrapyramidal syndrome
Frequency not known
–
Eye disorders
Blurred vision
–
Infrequent
Visual disturbances (including diplopia)
Infrequent
Rare
Ear and labyrinth disease
Tinnitus
Infrequent
Infrequent
Hearing loss
–
Very rare
Cardiac disorders
Palpitations
Frequent
–
Angina pectoris
Rare
–
Myocardial infarction
Very rare
–
Arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation)
Very rare
–
Vascular disorders
Flushing
Frequent
–
Hypotension
Infrequent
–
Vasculitis
Very rare
–
Respiratory, thoracic and mediastinal disorders
Pharyngolaryngeal pain
–
Frequent
Epistaxis
–
Frequent
Dyspnea
Infrequent
–
Rhinitis
Infrequent
–
Cough
Very rare
–
Interstitial lung disease, especially during long-term treatment
Frequency not known
Gastrointestinal disorders
Gingival hyperplasia
Very rare
–
Nausea
Frequent
Frequent
Upper and lower abdominal pain
Frequent
Infrequent
Vomiting
Infrequent
Infrequent
Dyspepsia
Infrequent
Frequent
Changes in intestinal transit (including diarrhea and constipation)
Infrequent
–
Dry mouth
Infrequent
–
Dysgeusia
Infrequent
–
Diarrhea, constipation, gas
–
Frequent
Gastritis
Very rare
–
Pancreatitis
Very rare
Infrequent
Eructation
–
Infrequent
Hepatobiliary disorders
Hepatitis
Very rare
Infrequent
Cholestasis
–
Rare
Jaundice
Very rare
–
Hepatic insufficiency
–
Very rare
Skin and subcutaneous tissue disorders
Bullous dermatosis including erythema multiforme
Very rare
Rare
Angioedema
Very rare
–
Erythema multiforme
Very rare
–
Alopecia
Infrequent
Infrequent
Purpura
Infrequent
–
Skin discoloration
Infrequent
–
Pruritus
Infrequent
Infrequent
Eruption
Infrequent
Infrequent
Hyperhidrosis
Infrequent
–
Exanthema
Infrequent
–
Urticaria
Very rare
Infrequent
Angioneurotic edema
Very rare
Rare
Exfoliative dermatitis
Very rare
–
Photosensitivity
Very rare
–
Stevens-Johnson syndrome
Very rare
Rare
Bullous erythroderma with epidermolysis
–
Rare
Musculoskeletal and connective tissue disorders
Swelling of the joints (including swelling of the ankles)
Frequent
Frequent
Arthralgia, myalgia
(see section Warnings and precautions for use )
Infrequent
Frequent
Muscle cramps, muscle spasms
Infrequent
Frequent
Back pain
Infrequent
Frequent
Neck pain
–
Infrequent
Pain in extremity
–
Frequent
Muscle fatigue
–
Infrequent
Myositis (see section Warnings and precautions for use )
–
Rare
Rhabdomyolysis, myopathy
(see section Warnings and precautions for use )
–
Rare
Tendinopathies, in rare cases tendon rupture
–
Rare
Immune-mediated necrotizing myopathy
–
Frequency not known
Kidney and urinary tract disorders
Urination disorder, nocturia, pollakiuria
Infrequent
–
Reproductive system and breast disorders
Incapacity
Infrequent
Infrequent
Gynecomastia
Infrequent
Very rare
General disorders and administration site conditions
Edema
Frequent
Infrequent
Peripheral edema
–
Infrequent
Tired
Frequent
Infrequent
Chest pain
Infrequent
Infrequent
Asthenia
Infrequent
Infrequent
Pain
Infrequent
–
Discomfort
Infrequent
Infrequent
Fever
–
Infrequent
Investigations
Increased liver enzymes: alanine aminotransferase, aspartate aminotransferase (mainly related to cholestasis)
Very rare
Frequent
Blood CK increased (see section 4.4 )
–
Frequent
Leukocyturia
–
Infrequent
* Diabetes: The frequency depends on the presence or absence of risk factors (fasting blood sugar ³ 5.6 mmol / l, BMI> 30 kg / m², increased triglyceride levels, history of high blood pressure).
caduet Interactions
Taking other medications
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets. This interaction may cause one or both of the medicines to be less effective, or on the contrary, this interaction may increase the risk or severity of side effects, including major muscle disorders known as rhabdomyolysis and myopathy (see section 4). .
Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets:
certain antibiotics such as rifampicin or certain “macrolide” antibiotics such as erythromycin, clarithromycin, telithromycin, fusidic acid or certain drugs used to treat infections caused by fungi such as ketoconazole, itraconazole,
medicines used to regulate lipid levels: fibrates, such as gemfibrozil or colestipol,
medicines used to regulate your heart rhythm, such as amiodarone, diltiazem and verapamil,
medicines used to treat or prevent seizures such as carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone,
medicines used to change how your immune system works, such as cyclosporin
protease inhibitors such as ritonavir, indinavir, nelfinavir used in the treatment of HIV,
medicines used to treat depression, such as nefazodone and imipramine,
medicines used to treat mental disorders, such as neuroleptics,
medicines used to treat heart failure, such as beta blockers
medicines used to treat high blood pressure, such as angiotensin II inhibitors, converting enzyme inhibitors, verapamil and diuretics,
alpha blockers used to treat high blood pressure or prostate problems
other medicines known to interact with CADUET 10 mg / 10 mg film-coated tablets such as ezetimibe (which lowers cholesterol), warfarin (which decreases blood clotting), oral contraceptives, stiripentol (an anticonvulsant used for treatment of epilepsy), cimetidine (used for heartburn and stomach ulcers), phenazone (a pain reliever), antacids (containing aluminum or magnesium, used to relieve problems stomach), and amifostine (used to treat cancer),
sildenafil (used in the treatment of erectile dysfunction, impotence),
dantrolene and baclofen (muscle relaxants),
steroids,
over-the-counter St. John’s Wort products.
CADUET may lower your blood pressure further if you are already taking other medicines to treat your high blood pressure.
If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, talk to your doctor or pharmacist.
INTERACTIONS OF CADUET 10 MG / 10 MG WITH FOOD AND DRINK
Food and drinks
CADUET 10 mg / 10 mg film-coated tablets can be taken at any time of the day, with or without food.
Grapefruit juice
Do not take more than one or two glasses of grapefruit juice per day as large amounts of grapefruit juice may affect the effects of CADUET 10 mg / 10 mg film-coated tablets.
Alcohol
Avoid drinking too much alcohol while taking CADUET 10 mg / 10 mg film-coated tablets. See also section 2 “Take special care with CADUET 10 mg / 10 mg film-coated tablets” for more details.
Drive and use machines
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Warnings and Precautions
Heart failure
Liver function monitoring
Clinical signs of hepatic dysfunction
Increased transaminases
Heavy alcohol consumption
Hepatic insufficiency
History of liver disease
Predisposing factor to the occurrence of rhabdomyolysis
Subject over 70 years of age
Unexplained muscle pain
Muscle cramp
Muscular weakness
Increase in CPK
Rhabdomyolysis
History of hemorrhagic stroke
History of lacunar infarction
Interstitial lung disease
Risk of diabetes
Woman of childbearing age
Heart failure
Patients with heart failure should be treated with caution. In a long-term placebo-controlled study in patients with severe heart failure (NYHA class III and IV), the reported incidence of pulmonary edema was higher in the amlodipine group compared to the placebo group. (see section Pharmacodynamic properties). Calcium channel blockers including amlodipine should be used with caution in patients with congestive heart failure because they may increase the risk of cardiovascular events and mortality.
Liver effects
Liver function tests should be performed before the start of treatment and then regularly after initiation of treatment, as well as in the event of signs or symptoms suggestive of liver damage. In the event of elevation of the serum transaminase level, monitoring is necessary until normalization.
A persistent increase in ALT or AST exceeding 3 times the upper limit of normal (ULN), should lead to discontinuation of treatment.
The half-life of amlodipine is increased and its AUC (Area Under the Curve) is greater in patients with hepatic impairment; dosage recommendations have not been established.
Due to the presence of atorvastatin, CADUET should be used with caution in patients who consume large amounts of alcohol, in patients with hepatic impairment and / or a history of liver disease.
Muscle effects
Like other HMG-CoA reductase inhibitors, atorvastatin can affect skeletal muscles and lead to myalgia, myositis and myopathies. These muscle damage may rarely progress to rhabdomyolysis, characterized by high levels of creatine kinase (CK) (more than 10 times the ULN), myoglobinemia and myoglobinuria which can lead to kidney failure, and in some cases be fatal.
Regular testing of CK or other muscle enzymes is not recommended in asymptomatic patients treated with statins. However, dosing of CKs is recommended before initiating statin therapy in patients with predisposing factors to rhabdomyolysis as well as in those with muscle symptoms during statin therapy (see below).
Very rare cases of autoimmune-mediated necrotizing myopathies (IMNM) have been reported during or after treatment with certain statins. IMNM is clinically characterized by proximal muscle weakness and increased serum creatine kinase, which persist despite discontinuation of statin therapy.
Before initiation of treatment
CADUET should be prescribed with caution in patients with predisposing factors to rhabdomyolysis. Before starting treatment with a statin, creatine kinase (CK) levels should be checked in the following situations:
Renal failure.
Hypothyroidism.
Personal or family history of genetic muscle diseases.
Personal history of muscle toxicity during treatment with a statin or a fibrate.
History of liver disease and / or excessive alcohol consumption.
In elderly patients (> 70 years), the need for these measures should be assessed, depending on the presence of other factors predisposing to rhabdomyolysis.
Situations in which increased plasma concentrations may occur, due to interactions (see section 4.5) and use in special populations including genetic polymorphisms (see section 5.2). ).
In these situations, a regular reassessment of the benefit / risk of the treatment, as well as regular clinical monitoring is recommended.
If the initial CK level is significantly elevated (more than 5 times the ULN) treatment should not be started.
Creatine kinase measurement
Creatine kinase (CK) should not be measured after heavy exercise or in the presence of another possible cause of increased CK, as this will make interpretation of the results difficult. In the event of a significant elevation of CK (more than 5 times the ULN) before treatment, this should be systematically checked again within 5 to 7 days to confirm the results.
During treatment
It is recommended that patients be asked to promptly report any unexplained muscle pain, muscle cramps or weakness, particularly if accompanied by malaise or fever.
· If symptoms appear when a patient is under treatment with CADUET, a CK levels should be measured; if the CK level is significantly elevated (more than 5 times the ULN), treatment should be discontinued.
· If muscular symptoms are severe and cause daily discomfort, discontinuation of treatment should be considered, even if CK levels did not exceed 5 times the ULN.
· If symptoms resolve and CK levels return to normal, the reintroduction of CADUET may be considered at the lowest dose and under close supervision.
Treatment with CADUET should be discontinued in the event of a clinically significant increase in CK level (> 10 times the ULN) or if rhabdomyolysis is diagnosed or suspected.
Amlodipine has no effect on laboratory parameters.
Combinations with other drugs
As with other statins, the risk of rhabdomyolysis is increased when CADUET is administered in combination with certain drugs which may increase the plasma concentration of atorvastatin, such as strong inhibitors of CYP3A4 or protein transporters (eg, cyclosporin, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole, determovir and HIV protease inhibitors including ritonavir, lopinavir, atazanavir, indinavir, darunavir, tipranavir, etc / ritonavir). The risk of myopathy may also be increased in combination with gemfibrozil and other fibrates, antivirals used in the treatment of hepatitis C (HCV) (boceprevir, telaprevir, elbasvir / grazoprevir), erythromycin, niacin, l ‘ ezetimibe or colchicine. Therapeutic alternatives (not exhibiting these interactions) should be considered as far as possible.
In the event that the combination of these medicinal products with CADUET is necessary, the benefit / risk of concomitant treatments should be carefully assessed and appropriate clinical monitoring is recommended (see section Interactions with other medicinal products and other forms of interactions).
CADUET should not be administered simultaneously with fusidic acid in systemic form, and for up to 7 days after stopping treatment with fusidic acid. In patients where the use of systemic fusidic acid is considered essential, statin therapy should be discontinued for the duration of fusidic acid therapy. Cases of rhabdomyolysis (some fatal) have been reported in patients receiving fusidic acid and a statin in combination (see section Interactions with other medicinal products and other forms of interactions). Patients should be informed of the need to seek immediate medical attention if they experience symptoms of muscle weakness, pain, or muscle tenderness.
Statin therapy can be restarted seven days after the last dose of fusidic acid.
In exceptional circumstances, when prolonged treatment with systemic fusidic acid is required, e.g. for the treatment of severe infections, the need for co-administration of CADUET and fusidic acid should only be considered in cases of per case and under close medical supervision.
Prevention of stroke by aggressively lowering cholesterol levels (SPARCL study)
In a posteriori analysis performed in subgroups of patients with recent stroke or transient ischemic attack (TIA) but without coronary artery disease, a higher frequency of hemorrhagic stroke was observed in treated patients. per 80 mg atorvastatin compared to patients on placebo.
This high risk is particularly observed in patients who have already had a hemorrhagic stroke or a lacunar infarction at the inclusion of the study.
In patients with a history of hemorrhagic stroke or lacunar infarction, the benefit / risk balance of atorvastatin 80 mg is uncertain. Therefore, the potential risk of occurrence of haemorrhagic stroke should be carefully assessed before any initiation of treatment (see section Pharmacodynamic properties).
Interstitial lung disease
Cases of interstitial lung disease have exceptionally been reported with certain statins, particularly during long-term therapy .
Symptoms may include dyspnea, a non-productive cough, and altered general condition (fatigue, weight loss, and fever). If interstitial lung disease is suspected in a patient, statin therapy should be discontinued.
Diabetes
There is some evidence that statins, as a pharmacological class, increase blood sugar. In some patients at high risk of developing diabetes, statins may cause hyperglycaemia requiring the initiation of diabetes treatment. This risk is nevertheless compensated by the reduction in the vascular risk under statins and therefore it should not be a reason for stopping statins. Patients at risk (fasting blood glucose between 5.6 and 6.9 mmol / l, BMI> 30 kg / m², increased triglyceride levels, arterial hypertension) should be monitored clinically and biologically in accordance with national recommendations.
PREGNANCY & BREAST-FEEDING & FERTILITY
Caduet is contraindicated during pregnancy and lactation.
Women of childbearing age
Women of childbearing potential should use reliable contraceptive measures during treatment ( see Contraindications ).
Pregnancy
The safety of atorvastatin has not been established in pregnant women. No controlled clinical trials have been performed in pregnant women treated with atorvastatin. Following intrauterine exposure to HMG-CoA reductase inhibitors, birth defects have rarely been reported. Studies in animals have shown reproductive toxicity ( see Preclinical safety ).
Treatment of the mother with atorvastatin may reduce the fetal level of mevalonate, which is a precursor of cholesterol biosynthesis. Atherosclerosis is a chronic process, and stopping a lipid-lowering drug during pregnancy should generally have little effect on the long-term risk associated with primary hypercholesterolemia.
For these reasons, Caduet should not be used during pregnancy, or in a woman planning to become pregnant or in whom pregnancy is suspected. Caduet treatment should be withheld during pregnancy or until it has been determined that the woman is not pregnant ( see Contraindications ).
If pregnancy is discovered during treatment, it should be stopped immediately.
Feeding with milk
Amlodipine is excreted in breast milk. The proportion of maternal dose received by the infant has been estimated at an interquartile range of 3-7%, with a maximum of 15%. The effect of amlodipine on infants is unknown. The excretion of atorvastatin or its metabolites in human milk is not known. In rats, the plasma concentrations of atorvastatin and its metabolites are similar to those found in milk ( see Preclinical safety ). Due to the possibility of serious side effects, women treated with Caduet should not breast-feed their infants ( see Contraindications ). Atorvastatin is contraindicated during breastfeeding ( see Contraindications ).
Fertility
No effect of atorvastatin on fertility has been demonstrated in studies conducted in male or female animals ( see Preclinical Safety ).
Reversible biochemical changes in the sperm head have been reported in some patients treated with calcium channel blockers. There is insufficient clinical data regarding the potential effect of amlodipine on fertility. In a study carried out in rats, adverse effects were detected on male fertility ( see Preclinical safety ).
What happens if I overdose from Caduet?
No information is available regarding overdose of Caduet in humans.
Amlodipine:
For amlodipine, experience with intentional overdose in humans is limited. Massive overdose could cause extensive peripheral vasodilation and possibly reflex tachycardia. Marked and possibly prolonged systemic hypotension up to and including shock with fatal outcome has been reported. Any hypotension resulting from acute intoxication requires monitoring in an intensive cardiological care unit. A vasoconstrictor can be used to restore vascular tone and blood pressure. Since amlodipine is highly protein bound, dialysis is unlikely to provide any benefit.
Atorvastatin:
There is no specific treatment for atorvastatin overdose. In the event of overdose, the patient should receive symptomatic treatment and supportive measures should be implemented as needed. Liver function and serum CK concentrations should be monitored. Due to the strong binding of the drug to plasma proteins, hemodialysis is not expected to significantly increase the clearance of atorvastatin.
What should I do if I miss a dose?
If you forget to take CADUET 5/ 10 mg -5/ 10 mg film-coated tablets:
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
What is Forms and Composition ?
SHAPES and PRESENTATIONS
5 mg / 10 mg film-coated tablet (oval, debossed with “Pfizer” on one side and “CDT 051” on the other side; white) and 10 mg / 10 mg (oval, debossed with “Pfizer “On one side and” CDT 101 “on the other side; blue): Boxes of 30 and 90, in blisters.
COMPOSITION
p cp Amlodipine (INN) as amlodipine besilate 5 mg or 10 mg Atorvastatin (INN) as atorvastatin calcium trihydrate 10 mg
Excipients (common): Core: calcium carbonate, croscarmellose sodium, microcrystalline cellulose, pregelatinized corn starch, polysorbate 80, hydroxypropylcellulose, colloidal anhydrous silica, magnesium stearate. Film- coating : 5 mg / 10 mg tablet: Opadry II white 85F28751 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc). 10 mg / 10 mg tablet: Opadry II blue 85F10919 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc, indigo carmine aluminum lake E132).
NOT’s
Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:
general information:
Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles
Additional information:
General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.
Special warnings:
For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.
Side effects:
It treats possible side effects and drug interactions that require attention and its effect on continuous use.
The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
The post caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings appeared first on Drug Online.
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caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings
Drug Online
caduet Generic drug of the Therapeutic class: Cardiology and angiology Active ingredients: Amlodipine , Atorvastatin
what is caduet medication?
This medication is supplied as blue, oval-shaped, film-coated tablets debossed with “Pfizer” on one side and “CDT 101” on the other side.
Boxes of 7, 10, 14, 20, 28, 30, 50, 56, 60, 90, 100 or 200 tablets.
Not all presentations may be marketed.
what is caduet medication used for and indication?
CADUET is indicated for the prevention of cardiovascular events in hypertensive patients with 3 associated cardiovascular risk factors, with normal to moderately elevated cholesterol without established coronary artery disease, and in whom, according to current recommendations, the concomitant use of amlodipine and a low dose of atorvastatin is suitable .
CADUET should be used when the response to regimen and other non-pharmacological measures is inadequate.
caduet dosage
Oral route
The usual starting dose is 5 mg / 10 mg once daily.
If tighter blood pressure control is required, a dosage of 10 mg / 10 mg once daily may be administered.
The tablets can be taken at any time of the day, with or without food.
CADUET can be used alone or in combination with other antihypertensive drugs, but it must not be used in combination with other calcium channel blockers or another statin.
The combination of CADUET and fibrates should generally be avoided (see sections 4.4 and Interactions with other medicinal products and other forms of interaction ).
Patients with renal impairment : No dosage adjustment is necessary in patients with impaired renal function (see sections 4.4 and Pharmacokinetic properties ).
Patients with hepatic impairment : CADUET is contraindicated in patients with active hepatic disease.
Children / Adolescents : The safety and efficacy of CADUET have not been established in children / adolescents. Therefore, the use of CADUET is not recommended in this population.
Elderly : It does not appear necessary to adjust the dose in the elderly (see section Pharmacokinetic properties ).
Combination with other medicinal products : In combination with ciclosporin, the dose of atorvastatin should not exceed 10 mg (see section Interactions with other medicinal products and other forms of interaction ).
Contraindications
CADUET is contraindicated in patients:
Being hypersensitive to dihydropyridines *, to amlodipine, to atorvastatin or to any of the excipients of this medicine,
have active liver disease or a persistent and unexplained increase in serum transaminases exceeding 3 times the upper limit of normal,
In women who are pregnant, breastfeeding or of childbearing potential and not using reliable contraceptive methods (see section Pregnancy and breast-feeding ),
In combination with itraconazole, ketoconazole, telithromycin (see section Interactions with other medicinal products and other forms of interactions ),
having severe hypotension,
Having shock (including cardiogenic shock),
Having an obstruction of the efferent pathway to the left ventricle (for example severe aortic stenosis),
With haemodynamically unstable heart failure after acute myocardial infarction.
* amlodipine is a calcium channel blocker derived from dihydropyridine.
HOW TO TAKE CADUET?
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if in doubt.
Adults
The recommended starting dose of CADUET is one 5 mg / 10 mg tablet per day. Your doctor may increase the dose if necessary to 1 tablet of CADUET 10 mg / 10 mg per day.
The tablets should be swallowed whole with a glass of water. They can be taken at any time of the day, with or without food. However, it is best to take them at the same time each day.
Continue to follow your doctor’s dietary advice, especially to eat a low fat diet, avoid tobacco, and exercise regularly.
If you have the impression that the effect of CADUET tablets is too strong or too weak, talk to your doctor or pharmacist.
Use in children and adolescents
This medication is not recommended for children and adolescents.
If you take more CADUET 10 mg / 10 mg film-coated tablets than you should
If you accidentally take too many CADUET tablets (more than your usual dose), ask your doctor or the nearest hospital for advice. Take any remaining tablets, the carton or the whole carton with you so that hospital staff can quickly identify which medicine you have taken.
If you forget to take CADUET 10 mg / 10 mg film-coated tablets
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
If you stop taking CADUET 10 mg / 10 mg film-coated tablets
Do not stop taking CADUET unless your doctor tells you to.
If you have any further questions on the use of this medicine or want to stop taking your treatment, ask your doctor or pharmacist for more information.
How To Store Caduet?
Keep this medication out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister, the carton and the vial after “EXP”. The expiration date refers to the last day of that month.
Store at a temperature not exceeding 30 ° C.
Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.
caduet side effects
The safety of CADUET has been evaluated in double-blind, placebo-controlled studies in 1092 patients treated for concomitant hypertension and dyslipidemia. During clinical trials with CADUET, no specific adverse events specific to this combination were observed.
Adverse events were limited to those previously reported for amlodipine and / or atorvastatin (see table of adverse events below).
In controlled clinical trials, discontinuation of treatment due to clinical adverse events or laboratory abnormalities was observed in 5.1% of patients treated with amlodipine and atorvastatin versus 4.0% of patients treated with amlodipine and atorvastatin. patients taking a placebo.
The adverse events below, listed according to MedDRA system organ classification and frequency order, relate to amlodipine and atorvastatin individually.
Very common: ³ 1/10, common: ³ 1/100 and <1/10, infrequent: ³ 1/1000 and <1/100, rare: ³ 1/10000 and <1/1000, very rare: < 1 / 10,000, frequency not known (cannot be estimated from the available data).
MedDRA
System organ classes
Side effects
Frequency
Amlodipine
Atorvastatin
Infections and infestations
Nasopharyngitis
–
Frequent
Blood and lymphatic system disorders
Leukopenia
Very rare
–
Thrombocytopenia
Very rare
Rare
Immune system disorders
hypersensitivity
Very rare
Frequent
Anaphylaxis
–
Very rare
Metabolism and nutrition disorders
Hyperglycemia *
Very rare
Frequent
Weight gain
Infrequent
Infrequent
Weightloss
Infrequent
–
Hypoglycemia
–
Infrequent
Anorexia
–
Infrequent
Psychiatric disorders
Insomnia
Infrequent
Infrequent
Mood disorders (including anxiety)
Infrequent
–
Nightmares
–
Infrequent
Depression
Infrequent
Frequency not known
Confusion
Rare
–
Disorders of the system nervous
Drowsiness
Frequent
–
Dizziness
Frequent
Infrequent
Headache (especially at the start of treatment)
Frequent
Frequent
Tremors
Infrequent
–
Hypoesthesias, paresthesias
Infrequent
Infrequent
Syncope
Infrequent
Hypertonia
Very rare
–
Peripheral neuropathy
Very rare
Rare
Amnesia
–
Infrequent
Dysgeusia
Infrequent
Infrequent
Extrapyramidal syndrome
Frequency not known
–
Eye disorders
Blurred vision
–
Infrequent
Visual disturbances (including diplopia)
Infrequent
Rare
Ear and labyrinth disease
Tinnitus
Infrequent
Infrequent
Hearing loss
–
Very rare
Cardiac disorders
Palpitations
Frequent
–
Angina pectoris
Rare
–
Myocardial infarction
Very rare
–
Arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation)
Very rare
–
Vascular disorders
Flushing
Frequent
–
Hypotension
Infrequent
–
Vasculitis
Very rare
–
Respiratory, thoracic and mediastinal disorders
Pharyngolaryngeal pain
–
Frequent
Epistaxis
–
Frequent
Dyspnea
Infrequent
–
Rhinitis
Infrequent
–
Cough
Very rare
–
Interstitial lung disease, especially during long-term treatment
Frequency not known
Gastrointestinal disorders
Gingival hyperplasia
Very rare
–
Nausea
Frequent
Frequent
Upper and lower abdominal pain
Frequent
Infrequent
Vomiting
Infrequent
Infrequent
Dyspepsia
Infrequent
Frequent
Changes in intestinal transit (including diarrhea and constipation)
Infrequent
–
Dry mouth
Infrequent
–
Dysgeusia
Infrequent
–
Diarrhea, constipation, gas
–
Frequent
Gastritis
Very rare
–
Pancreatitis
Very rare
Infrequent
Eructation
–
Infrequent
Hepatobiliary disorders
Hepatitis
Very rare
Infrequent
Cholestasis
–
Rare
Jaundice
Very rare
–
Hepatic insufficiency
–
Very rare
Skin and subcutaneous tissue disorders
Bullous dermatosis including erythema multiforme
Very rare
Rare
Angioedema
Very rare
–
Erythema multiforme
Very rare
–
Alopecia
Infrequent
Infrequent
Purpura
Infrequent
–
Skin discoloration
Infrequent
–
Pruritus
Infrequent
Infrequent
Eruption
Infrequent
Infrequent
Hyperhidrosis
Infrequent
–
Exanthema
Infrequent
–
Urticaria
Very rare
Infrequent
Angioneurotic edema
Very rare
Rare
Exfoliative dermatitis
Very rare
–
Photosensitivity
Very rare
–
Stevens-Johnson syndrome
Very rare
Rare
Bullous erythroderma with epidermolysis
–
Rare
Musculoskeletal and connective tissue disorders
Swelling of the joints (including swelling of the ankles)
Frequent
Frequent
Arthralgia, myalgia
(see section Warnings and precautions for use )
Infrequent
Frequent
Muscle cramps, muscle spasms
Infrequent
Frequent
Back pain
Infrequent
Frequent
Neck pain
–
Infrequent
Pain in extremity
–
Frequent
Muscle fatigue
–
Infrequent
Myositis (see section Warnings and precautions for use )
–
Rare
Rhabdomyolysis, myopathy
(see section Warnings and precautions for use )
–
Rare
Tendinopathies, in rare cases tendon rupture
–
Rare
Immune-mediated necrotizing myopathy
–
Frequency not known
Kidney and urinary tract disorders
Urination disorder, nocturia, pollakiuria
Infrequent
–
Reproductive system and breast disorders
Incapacity
Infrequent
Infrequent
Gynecomastia
Infrequent
Very rare
General disorders and administration site conditions
Edema
Frequent
Infrequent
Peripheral edema
–
Infrequent
Tired
Frequent
Infrequent
Chest pain
Infrequent
Infrequent
Asthenia
Infrequent
Infrequent
Pain
Infrequent
–
Discomfort
Infrequent
Infrequent
Fever
–
Infrequent
Investigations
Increased liver enzymes: alanine aminotransferase, aspartate aminotransferase (mainly related to cholestasis)
Very rare
Frequent
Blood CK increased (see section 4.4 )
–
Frequent
Leukocyturia
–
Infrequent
* Diabetes: The frequency depends on the presence or absence of risk factors (fasting blood sugar ³ 5.6 mmol / l, BMI> 30 kg / m², increased triglyceride levels, history of high blood pressure).
caduet Interactions
Taking other medications
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets. This interaction may cause one or both of the medicines to be less effective, or on the contrary, this interaction may increase the risk or severity of side effects, including major muscle disorders known as rhabdomyolysis and myopathy (see section 4). .
Some medicines may interact with CADUET 10 mg / 10 mg film-coated tablets:
certain antibiotics such as rifampicin or certain “macrolide” antibiotics such as erythromycin, clarithromycin, telithromycin, fusidic acid or certain drugs used to treat infections caused by fungi such as ketoconazole, itraconazole,
medicines used to regulate lipid levels: fibrates, such as gemfibrozil or colestipol,
medicines used to regulate your heart rhythm, such as amiodarone, diltiazem and verapamil,
medicines used to treat or prevent seizures such as carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone,
medicines used to change how your immune system works, such as cyclosporin
protease inhibitors such as ritonavir, indinavir, nelfinavir used in the treatment of HIV,
medicines used to treat depression, such as nefazodone and imipramine,
medicines used to treat mental disorders, such as neuroleptics,
medicines used to treat heart failure, such as beta blockers
medicines used to treat high blood pressure, such as angiotensin II inhibitors, converting enzyme inhibitors, verapamil and diuretics,
alpha blockers used to treat high blood pressure or prostate problems
other medicines known to interact with CADUET 10 mg / 10 mg film-coated tablets such as ezetimibe (which lowers cholesterol), warfarin (which decreases blood clotting), oral contraceptives, stiripentol (an anticonvulsant used for treatment of epilepsy), cimetidine (used for heartburn and stomach ulcers), phenazone (a pain reliever), antacids (containing aluminum or magnesium, used to relieve problems stomach), and amifostine (used to treat cancer),
sildenafil (used in the treatment of erectile dysfunction, impotence),
dantrolene and baclofen (muscle relaxants),
steroids,
over-the-counter St. John’s Wort products.
CADUET may lower your blood pressure further if you are already taking other medicines to treat your high blood pressure.
If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, talk to your doctor or pharmacist.
INTERACTIONS OF CADUET 10 MG / 10 MG WITH FOOD AND DRINK
Food and drinks
CADUET 10 mg / 10 mg film-coated tablets can be taken at any time of the day, with or without food.
Grapefruit juice
Do not take more than one or two glasses of grapefruit juice per day as large amounts of grapefruit juice may affect the effects of CADUET 10 mg / 10 mg film-coated tablets.
Alcohol
Avoid drinking too much alcohol while taking CADUET 10 mg / 10 mg film-coated tablets. See also section 2 “Take special care with CADUET 10 mg / 10 mg film-coated tablets” for more details.
Drive and use machines
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Do not drive or use machines if you feel dizzy after taking this medicine.
Warnings and Precautions
Heart failure
Liver function monitoring
Clinical signs of hepatic dysfunction
Increased transaminases
Heavy alcohol consumption
Hepatic insufficiency
History of liver disease
Predisposing factor to the occurrence of rhabdomyolysis
Subject over 70 years of age
Unexplained muscle pain
Muscle cramp
Muscular weakness
Increase in CPK
Rhabdomyolysis
History of hemorrhagic stroke
History of lacunar infarction
Interstitial lung disease
Risk of diabetes
Woman of childbearing age
Heart failure
Patients with heart failure should be treated with caution. In a long-term placebo-controlled study in patients with severe heart failure (NYHA class III and IV), the reported incidence of pulmonary edema was higher in the amlodipine group compared to the placebo group. (see section Pharmacodynamic properties). Calcium channel blockers including amlodipine should be used with caution in patients with congestive heart failure because they may increase the risk of cardiovascular events and mortality.
Liver effects
Liver function tests should be performed before the start of treatment and then regularly after initiation of treatment, as well as in the event of signs or symptoms suggestive of liver damage. In the event of elevation of the serum transaminase level, monitoring is necessary until normalization.
A persistent increase in ALT or AST exceeding 3 times the upper limit of normal (ULN), should lead to discontinuation of treatment.
The half-life of amlodipine is increased and its AUC (Area Under the Curve) is greater in patients with hepatic impairment; dosage recommendations have not been established.
Due to the presence of atorvastatin, CADUET should be used with caution in patients who consume large amounts of alcohol, in patients with hepatic impairment and / or a history of liver disease.
Muscle effects
Like other HMG-CoA reductase inhibitors, atorvastatin can affect skeletal muscles and lead to myalgia, myositis and myopathies. These muscle damage may rarely progress to rhabdomyolysis, characterized by high levels of creatine kinase (CK) (more than 10 times the ULN), myoglobinemia and myoglobinuria which can lead to kidney failure, and in some cases be fatal.
Regular testing of CK or other muscle enzymes is not recommended in asymptomatic patients treated with statins. However, dosing of CKs is recommended before initiating statin therapy in patients with predisposing factors to rhabdomyolysis as well as in those with muscle symptoms during statin therapy (see below).
Very rare cases of autoimmune-mediated necrotizing myopathies (IMNM) have been reported during or after treatment with certain statins. IMNM is clinically characterized by proximal muscle weakness and increased serum creatine kinase, which persist despite discontinuation of statin therapy.
Before initiation of treatment
CADUET should be prescribed with caution in patients with predisposing factors to rhabdomyolysis. Before starting treatment with a statin, creatine kinase (CK) levels should be checked in the following situations:
Renal failure.
Hypothyroidism.
Personal or family history of genetic muscle diseases.
Personal history of muscle toxicity during treatment with a statin or a fibrate.
History of liver disease and / or excessive alcohol consumption.
In elderly patients (> 70 years), the need for these measures should be assessed, depending on the presence of other factors predisposing to rhabdomyolysis.
Situations in which increased plasma concentrations may occur, due to interactions (see section 4.5) and use in special populations including genetic polymorphisms (see section 5.2). ).
In these situations, a regular reassessment of the benefit / risk of the treatment, as well as regular clinical monitoring is recommended.
If the initial CK level is significantly elevated (more than 5 times the ULN) treatment should not be started.
Creatine kinase measurement
Creatine kinase (CK) should not be measured after heavy exercise or in the presence of another possible cause of increased CK, as this will make interpretation of the results difficult. In the event of a significant elevation of CK (more than 5 times the ULN) before treatment, this should be systematically checked again within 5 to 7 days to confirm the results.
During treatment
It is recommended that patients be asked to promptly report any unexplained muscle pain, muscle cramps or weakness, particularly if accompanied by malaise or fever.
· If symptoms appear when a patient is under treatment with CADUET, a CK levels should be measured; if the CK level is significantly elevated (more than 5 times the ULN), treatment should be discontinued.
· If muscular symptoms are severe and cause daily discomfort, discontinuation of treatment should be considered, even if CK levels did not exceed 5 times the ULN.
· If symptoms resolve and CK levels return to normal, the reintroduction of CADUET may be considered at the lowest dose and under close supervision.
Treatment with CADUET should be discontinued in the event of a clinically significant increase in CK level (> 10 times the ULN) or if rhabdomyolysis is diagnosed or suspected.
Amlodipine has no effect on laboratory parameters.
Combinations with other drugs
As with other statins, the risk of rhabdomyolysis is increased when CADUET is administered in combination with certain drugs which may increase the plasma concentration of atorvastatin, such as strong inhibitors of CYP3A4 or protein transporters (eg, cyclosporin, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole, determovir and HIV protease inhibitors including ritonavir, lopinavir, atazanavir, indinavir, darunavir, tipranavir, etc / ritonavir). The risk of myopathy may also be increased in combination with gemfibrozil and other fibrates, antivirals used in the treatment of hepatitis C (HCV) (boceprevir, telaprevir, elbasvir / grazoprevir), erythromycin, niacin, l ‘ ezetimibe or colchicine. Therapeutic alternatives (not exhibiting these interactions) should be considered as far as possible.
In the event that the combination of these medicinal products with CADUET is necessary, the benefit / risk of concomitant treatments should be carefully assessed and appropriate clinical monitoring is recommended (see section Interactions with other medicinal products and other forms of interactions).
CADUET should not be administered simultaneously with fusidic acid in systemic form, and for up to 7 days after stopping treatment with fusidic acid. In patients where the use of systemic fusidic acid is considered essential, statin therapy should be discontinued for the duration of fusidic acid therapy. Cases of rhabdomyolysis (some fatal) have been reported in patients receiving fusidic acid and a statin in combination (see section Interactions with other medicinal products and other forms of interactions). Patients should be informed of the need to seek immediate medical attention if they experience symptoms of muscle weakness, pain, or muscle tenderness.
Statin therapy can be restarted seven days after the last dose of fusidic acid.
In exceptional circumstances, when prolonged treatment with systemic fusidic acid is required, e.g. for the treatment of severe infections, the need for co-administration of CADUET and fusidic acid should only be considered in cases of per case and under close medical supervision.
Prevention of stroke by aggressively lowering cholesterol levels (SPARCL study)
In a posteriori analysis performed in subgroups of patients with recent stroke or transient ischemic attack (TIA) but without coronary artery disease, a higher frequency of hemorrhagic stroke was observed in treated patients. per 80 mg atorvastatin compared to patients on placebo.
This high risk is particularly observed in patients who have already had a hemorrhagic stroke or a lacunar infarction at the inclusion of the study.
In patients with a history of hemorrhagic stroke or lacunar infarction, the benefit / risk balance of atorvastatin 80 mg is uncertain. Therefore, the potential risk of occurrence of haemorrhagic stroke should be carefully assessed before any initiation of treatment (see section Pharmacodynamic properties).
Interstitial lung disease
Cases of interstitial lung disease have exceptionally been reported with certain statins, particularly during long-term therapy .
Symptoms may include dyspnea, a non-productive cough, and altered general condition (fatigue, weight loss, and fever). If interstitial lung disease is suspected in a patient, statin therapy should be discontinued.
Diabetes
There is some evidence that statins, as a pharmacological class, increase blood sugar. In some patients at high risk of developing diabetes, statins may cause hyperglycaemia requiring the initiation of diabetes treatment. This risk is nevertheless compensated by the reduction in the vascular risk under statins and therefore it should not be a reason for stopping statins. Patients at risk (fasting blood glucose between 5.6 and 6.9 mmol / l, BMI> 30 kg / m², increased triglyceride levels, arterial hypertension) should be monitored clinically and biologically in accordance with national recommendations.
PREGNANCY & BREAST-FEEDING & FERTILITY
Caduet is contraindicated during pregnancy and lactation.
Women of childbearing age
Women of childbearing potential should use reliable contraceptive measures during treatment ( see Contraindications ).
Pregnancy
The safety of atorvastatin has not been established in pregnant women. No controlled clinical trials have been performed in pregnant women treated with atorvastatin. Following intrauterine exposure to HMG-CoA reductase inhibitors, birth defects have rarely been reported. Studies in animals have shown reproductive toxicity ( see Preclinical safety ).
Treatment of the mother with atorvastatin may reduce the fetal level of mevalonate, which is a precursor of cholesterol biosynthesis. Atherosclerosis is a chronic process, and stopping a lipid-lowering drug during pregnancy should generally have little effect on the long-term risk associated with primary hypercholesterolemia.
For these reasons, Caduet should not be used during pregnancy, or in a woman planning to become pregnant or in whom pregnancy is suspected. Caduet treatment should be withheld during pregnancy or until it has been determined that the woman is not pregnant ( see Contraindications ).
If pregnancy is discovered during treatment, it should be stopped immediately.
Feeding with milk
Amlodipine is excreted in breast milk. The proportion of maternal dose received by the infant has been estimated at an interquartile range of 3-7%, with a maximum of 15%. The effect of amlodipine on infants is unknown. The excretion of atorvastatin or its metabolites in human milk is not known. In rats, the plasma concentrations of atorvastatin and its metabolites are similar to those found in milk ( see Preclinical safety ). Due to the possibility of serious side effects, women treated with Caduet should not breast-feed their infants ( see Contraindications ). Atorvastatin is contraindicated during breastfeeding ( see Contraindications ).
Fertility
No effect of atorvastatin on fertility has been demonstrated in studies conducted in male or female animals ( see Preclinical Safety ).
Reversible biochemical changes in the sperm head have been reported in some patients treated with calcium channel blockers. There is insufficient clinical data regarding the potential effect of amlodipine on fertility. In a study carried out in rats, adverse effects were detected on male fertility ( see Preclinical safety ).
What happens if I overdose from Caduet?
No information is available regarding overdose of Caduet in humans.
Amlodipine:
For amlodipine, experience with intentional overdose in humans is limited. Massive overdose could cause extensive peripheral vasodilation and possibly reflex tachycardia. Marked and possibly prolonged systemic hypotension up to and including shock with fatal outcome has been reported. Any hypotension resulting from acute intoxication requires monitoring in an intensive cardiological care unit. A vasoconstrictor can be used to restore vascular tone and blood pressure. Since amlodipine is highly protein bound, dialysis is unlikely to provide any benefit.
Atorvastatin:
There is no specific treatment for atorvastatin overdose. In the event of overdose, the patient should receive symptomatic treatment and supportive measures should be implemented as needed. Liver function and serum CK concentrations should be monitored. Due to the strong binding of the drug to plasma proteins, hemodialysis is not expected to significantly increase the clearance of atorvastatin.
What should I do if I miss a dose?
If you forget to take CADUET 5/ 10 mg -5/ 10 mg film-coated tablets:
If you forget to take your dose of CADUET, take your next dose at the normal time.
Do not take a double dose to make up for the dose you forgot to take.
What is Forms and Composition ?
SHAPES and PRESENTATIONS
5 mg / 10 mg film-coated tablet (oval, debossed with “Pfizer” on one side and “CDT 051” on the other side; white) and 10 mg / 10 mg (oval, debossed with “Pfizer “On one side and” CDT 101 “on the other side; blue): Boxes of 30 and 90, in blisters.
COMPOSITION
p cp Amlodipine (INN) as amlodipine besilate 5 mg or 10 mg Atorvastatin (INN) as atorvastatin calcium trihydrate 10 mg
Excipients (common): Core: calcium carbonate, croscarmellose sodium, microcrystalline cellulose, pregelatinized corn starch, polysorbate 80, hydroxypropylcellulose, colloidal anhydrous silica, magnesium stearate. Film- coating : 5 mg / 10 mg tablet: Opadry II white 85F28751 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc). 10 mg / 10 mg tablet: Opadry II blue 85F10919 (polyvinyl alcohol, titanium dioxide E171, macrogol 3000, talc, indigo carmine aluminum lake E132).
NOT’s
Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:
general information:
Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles
Additional information:
General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.
Special warnings:
For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.
Side effects:
It treats possible side effects and drug interactions that require attention and its effect on continuous use.
The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
The post caduet tablets Uses, Dosage, Side Effects, Precautions & Warnings appeared first on Drug Online.
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Epistaxis Market Size, Trends, Shares, Insights and Forecast - 2027
To Gain More Insights into the Epistaxis Market, Browse Summary of the Research Report –
Epistaxis, also known as nosebleed, occurs due to rupture of small blood vessel in the lining of nose, as the interior of the nose is highly delicate and sensitive. Also, the interior of nose cannot tolerate certain factors that make the cells fragile and prone to burst resulting in bleeding. Nosebleeds are common during winter season, as upper respiratory infections mostly occur during this season.
In most cases, epistaxis responds effectively to nasal cauterization or nasal packaging or both the treatments. People experiencing recurrent bouts of nosebleeds are usually recommended to undergo surgical options or embolization procedures that are available in hospitals and ENT clinics. The most common treatment adopted for epistaxis patients is either chemical or electrical cautery. This method is easy to perform, cheap, and does not involve any serious risk. Cauterization refers to a procedure, in which a small tissue at the bleeding site is removed or burnt with the help of chemicals such as silver nitrate or mild electric shocks.
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Moreover, various topical applications such as tranexamic acid are available in the market that helps to curtail nosebleeds. According to a research article published in International Journal of Otolaryngology in 2015, epistaxis is estimated to affect around 10-12% of the global population, of which around 80% patients require medical attention, as majority of epistaxis cases are not self-limiting and cannot be resolved due to intervention. An increasing number of cases of nosebleeds is expected to drive growth of the global epistaxis market.
The global epistaxis market size is estimated to be valued at US$ 145.9 million in 2019 and is expected to witness a CAGR of 5.4% over the forecast period (2019–2027).
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Table of Contents
Research Objectives and Assumptions
Research Objectives
Assumptions
Abbreviations
Market Purview
Report Description
Market Definition and Scope
Executive Summary
Market Snippet, By Drug Type
Market Snippet, By Distribution Channel
Market Snippet, By Region
Coherent Opportunity Map (COM)
Market Dynamics, Regulations, and Trends Analysis
Market Dynamics
Drivers
Restraints
Market Opportunities
Impact Analysis
Market Trends
Regulatory Scenario
Reimbursement Scenario
Epidemiology
PEST Analysis
Recent Product Launch
Merger and Acquisition Scenario
Top players in the market
Key players operating in the global epistaxis market include Smith & Nephew, Medline Industries, Inc., Bristol-Myers Squibb Pharma Company, Ciron Drugs, and King Pharmaceuticals, Inc.
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Nosebleeds Market 2020 Industry Research, Share, Trend, Industry Size, Price, Future Analysis, Regional Outlook to 2027 Research Report | DBMR Updates
This Nosebleeds Market research document predicts the size of the market with information on key vendor revenues, development of the industry by upstream & downstream, industry progress, key companies, along with type segment & market application. This market study takes into account a market attractiveness analysis, where each segment is benchmarked based on its market size, growth rate, and general attractiveness. Another major section of this Nosebleeds Market report is the competitive landscape which provides a clear insight into the market share analysis and actions of key industry players. Quality and transparency is strictly maintained while carrying out research studies to offer an exceptional market research document for your niche.
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All the data of this market report is exceptionally useful to the clients and businesses for making decisions related to revenue, investment, import, export and consumption. To meet the strategic as well as specific needs of the organization or business, a comprehensive market research document such as this Nosebleeds Market report, has to be in place. Geographical scope of the products is also carried out comprehensively for the major global areas such as Asia, North America, South America, and Africa which helps define strategies for the product distribution in those areas. Competitive landscape is explored in terms of product range, strategies, and future prospects of the key players of the Healthcare industry.
Market Analysis: Besides target market information, DBMR also provides information about your competitor, your customers, products etc. A few techniques we use are: Customer analysis Competitor analysis Risk analysis Product research Advertising research E-mail survey and many more…
Global nosebleeds market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period. Emerging markets and huge investment in research and development are the factors responsible for the growth of this market.
The major players covered in the nosebleeds market are Ferring B.V., Teva Pharmaceutical Industries Ltd, Apotex Inc, Mylan N.V., Renatus, LLC, Sun Pharmaceutical Industries Ltd, Amneal Pharmaceuticals Inc Glenmark Pharmaceuticals Inc, Alkem Labs, Strides Pharma Science Limited and others.
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Market Analysis and Insights: Global Nosebleeds Market
The growth of nosebleeds market enhanced by the growing cases of nosebleeds and availability of treatment options. In addition, change in environment and rise in cases of hypertension which leads to increasing blood flow towards the mucous membrane are some of the impacting factors for the demand of nosebleeds drugs. Nevertheless, huge financial burden coupled with lack of skilled professionals are the factors that hinder the growth of this market.
Nosebleeds is also termed as epistaxis is a condition in which frequent bleeding occurs from the blood vessels in the nose. It is most commonly found in the children and often caused by the trauma, nasal picking, emergence of foreign body, infections of nose and others.
Nosebleeds market provides details of market share, new developments and product pipeline analysis, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions and technological innovations in the market. To understand the analysis and the market scenario contact us for an Analyst Brief, our team will help you create a revenue impact solution to achieve your desired goal.
Global Nosebleeds Market Scope and Market Size
Nosebleeds market is segmented on the basis of treatment type, route of administration, end-users and distribution channel.
Based on treatment type, the global nosebleeds market is segmented into vasoconstrictors, anesthetics, antibiotic ointments, cauterizing agents and others.
Route of administration segment for global nosebleeds market is categorized into oral, intranasal and others
On the basis of end-users, the global nosebleeds market is segmented into hospitals, homecare, specialty clinics and others.
On the basis of distribution channel, the global nosebleeds market has been bifurcated into hospital pharmacy, online pharmacy and retail pharmacy.
Global Nosebleeds Market Country Level Analysis
Global nosebleeds market is analyzed and market size information is provided by country, treatment type, route of administration, end-users and distribution channel as referenced above.
The countries covered in the global nosebleeds market report are U.S., Canada, Mexico in North America, Brazil, Argentina, Peru, Rest of South America, as part of South America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific, Saudi Arabia, in the Asia-Pacific, U.A.E, Egypt, Israel, Kuwait, South Africa, Rest of Middle East and Africa, as a part of Middle East and Africa.
In terms of regions, North America is projected to dominate for nosebleeds market throughout the forecasted period owing to the presence of extreme weather conditions which can leads to nose bleeding and rise in patient assistance programs. Europe is considered a second largest growing regional segment due to the high cases of nosebleeds. Asia-Pacific leads the market due to the developing healthcare facilities, large number of generic manufacturer and rise in government initiatives and specialist communities.
The country section of the report also provides individual market impacting factors and changes in regulations in the market domestically that impacts the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, disease epidemiology and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of sales channels are considered while providing forecast analysis of the country data.
Patient Epidemiology Analysis
Nosebleeds market also provides you with detailed market analysis for patient analysis, prognosis and cures. Prevalence, incidence, mortality, adherence rates are some of the data variables that are available in the report. Direct or indirect impact analysis of epidemiology to market growth are analyzed to create a more robust and cohort multivariate statistical model for forecasting the market in the growth period.
Competitive Landscape and Global Nosebleeds Market Share Analysis
Nosebleeds market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, company strengths and weaknesses, product launch, clinical trials pipelines, product approvals, patents, product width and breadth, application dominance, technology lifeline curve. The above data points provided are only related to the companies’ focus related to nosebleeds market.
Customization Available: Global Nosebleeds Market
Data Bridge Market Research is a leader in advanced formative research. We take pride in servicing our existing and new customers with data and analysis that match and suits their goal. The report can be customized to include price trend analysis of target brands understanding the market for additional countries (ask for the list of countries), clinical trial results data, literature review, refurbished market and product base analysis. Market analysis of target competitors can be analyzed from technology-based analysis to market portfolio strategies. We can add as many competitors that you require data about in the format and data style you are looking for. Our team of analysts can also provide you data in crude raw excel files pivot tables (Factbook) or can assist you in creating presentations from the data sets available in the report.
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