#DVT tx
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mcatmemoranda · 1 year ago
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Definitions – Proximal deep vein thrombosis (DVT) is one that is located in the popliteal, femoral, or iliac veins (table 2). Distal DVT is confined to the calf veins (peroneal, posterior, anterior tibial, and muscular veins) (table 1).
●Patient selection for anticoagulation
•Proximal DVT – The following is our strategy for anticoagulation in patients with proximal DVT (algorithm 1):
-Low risk of bleeding – For most patients with acute proximal DVT of the lower extremity in whom the risk of bleeding is not high (table 3), we recommend therapeutic anticoagulation rather than no anticoagulation (algorithm 1). This approach is supported by older data that demonstrated a survival benefit compared with no anticoagulation. In addition, subsequent data support a low rate of venous thromboembolism recurrence in patients treated with variable durations of anticoagulant therapy and the higher risk of embolization from thrombus located in the proximal veins compared with the distal veins. While data are strongest in symptomatic patients, it is reasonable to expect that the same benefit applies to asymptomatic patients.
-High risk of bleeding – For patients with acute proximal DVT of the lower extremity who have contraindications or a high risk of bleeding, we suggest prompt placement of an inferior vena cava (IVC) filter (Grade 2C). This approach is based upon data that suggest low rates of pulmonary embolism (PE) when IVC filters are placed. We prefer retrievable filters for the avoidance of long-term complications of filter placement, particularly recurrent DVT. A conventional course of anticoagulation should be administered once the contraindication resolves.
•Distal DVT – The following is our approach to patients with distal DVT of the lower extremity (algorithm 2):
-Low risk of bleeding, high risk of embolization – For patients with distal DVT who are considered to be at high risk of embolization and in whom the risk of bleeding is not high (table 3), we suggest anticoagulation rather than serial monitoring with compression ultrasonography (Grade 2C). This includes most patients who are symptomatic and/or those with features that suggest a high risk of embolization listed on the table (table 4). Support for this approach is based upon a high likelihood of embolization and the proven efficacy of anticoagulation in reducing thrombus extension and subsequent embolization in this population. Occasionally, some patients with minor symptoms who have features that support a low risk of embolization may reasonably opt out of anticoagulation and undergo surveillance.
-Low risk of bleeding and embolization – For most patients with distal DVT who are at low risk of embolization and in whom the risk of bleeding is not high (table 3), we suggest surveillance with serial ultrasound over a two-week period rather than anticoagulation (Grade 2C). Features that are considered to be associated with a low risk of embolization are listed in the table (table 4). For patients who exhibit any signs of thrombus extension during surveillance, we suggest anticoagulation rather than continued surveillance (Grade 2C). This approach is derived from data that suggest a low likelihood of proximal extension (and therefore embolization) without therapy in this population.
-High risk of bleeding – For patients with acute distal DVT of the lower extremity who have contraindications or a high risk of bleeding, we suggest surveillance ultrasonography rather than IVC filter placement. If a proximal DVT develops, an IVC filter should be placed.
●Anticoagulation therapy
•Initial anticoagulation – In most patients, anticoagulation should be started immediately as a delay in therapy increases the risk of potentially life-threatening embolization. Selecting an anticoagulant (table 6), dosing for parenteral and oral anticoagulants, and empiric anticoagulation are discussed in detail separately.
•Outpatient anticoagulation – Outpatient anticoagulation rather than inpatient therapy can be considered when patients are hemodynamically stable, have a low risk of bleeding, do not have severe renal insufficiency, and have a practical system in place at home for the administration and surveillance of anticoagulant therapy (table 7). It is not appropriate in patients with massive DVT (eg, iliofemoral DVT, phlegmasia cerulea dolens), concurrent PE, a high risk of bleeding on anticoagulant therapy, comorbid conditions, or other factors that warrant in-hospital care.
•Long-term anticoagulation – In general, we treat for a minimum of three months.
●Ambulation and graduated compression stockings – For most patients with acute DVT of the lower extremity who are fully anticoagulated, hemodynamically stable, and whose symptoms are under control (eg, pain, swelling), we encourage early ambulation in preference to bed rest. We suggest that elastic graduated compression stockings (GCS) not be administered in patients for the prevention of post-thrombotic (postphlebitic) syndrome (PTS) (Grade 2C). The latter is based upon data from a randomized trial that suggested no benefit from GCS and the observation that many patients decline their use because they are uncomfortable, costly, inconvenient, and often require a healthcare giver for their application. GCS may be applied for symptom control or established PTS, the details of which are discussed separately.
●Thrombolytic therapy and thrombectomy – For most patients with acute lower extremity DVT, thrombolytic therapy and/or thrombectomy is not indicated. These therapies are usually reserved for patients with phlegmasia cerulea dolens or massive iliofemoral DVT or for patients who fail therapeutic anticoagulation.
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nursingscience · 2 years ago
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Medical Abbreviations on Pharmacy Prescriptions
Here are some common medical abbreviations you may see on pharmacy prescriptions:
qd - once a day
bid - twice a day
tid - three times a day
qid - four times a day
qh - every hour
prn - as needed
pc - after meals
ac - before meals
hs - at bedtime
po - by mouth
IV - intravenous
IM - intramuscular
subQ - subcutaneous
mL - milliliter
mg - milligram
g - gram
mcg - microgram
stat - immediately, right away
NPO - nothing by mouth
cap - capsule
tab - tablet
susp - suspension
sol - solution
amp - ampule
inj - injection
Rx - prescription
C - Celsius
F - Fahrenheit
BP - blood pressure
HR - heart rate
RR - respiratory rate
WBC - white blood cell
RBC - red blood cell
Hgb - hemoglobin
Hct - hematocrit
PT - prothrombin time
INR - international normalized ratio
BUN - blood urea nitrogen
Cr - creatinine
Ca - calcium
K - potassium
Na - sodium
Cl - chloride
Mg - magnesium
PO2 - partial pressure of oxygen
PCO2 - partial pressure of carbon dioxide
ABG - arterial blood gas
CBC - complete blood count
BMP - basic metabolic panel
CMP - comprehensive metabolic panel.
ECG - electrocardiogram
EEG - electroencephalogram
MRI - magnetic resonance imaging
CT - computed tomography
PET - positron emission tomography
CXR - chest x-ray
CTX - chemotherapy
NSAID - nonsteroidal anti-inflammatory drug
DMARD - disease-modifying antirheumatic drug
ACE - angiotensin-converting enzyme
ARB - angiotensin receptor blocker
SSRI - selective serotonin reuptake inhibitor
TCA - tricyclic antidepressant
ADHD - attention deficit hyperactivity disorder
COPD - chronic obstructive pulmonary disease
CAD - coronary artery disease
CHF - congestive heart failure
DVT - deep vein thrombosis
GI - gastrointestinal
UTI - urinary tract infection
OTC - over-the-counter
Rx - prescription
OD - right eye
OS - left eye
OU - both eyes.
TID - thrombosis in dementia
TDS - ter die sumendum (three times a day)
BOM - bilaterally otitis media (infection in both ears)
BT - body temperature
C&S - culture and sensitivity
D/C - discontinue or discharge
D/W - dextrose in water
ETOH - ethyl alcohol
FUO - fever of unknown origin
H&P - history and physical examination
I&D - incision and drainage
I&O - intake and output
KVO - keep vein open
N&V - nausea and vomiting
PERRLA - pupils equal, round, reactive to light and accommodation
PR - per rectum
QAM - every morning
QHS - every bedtime
QOD - every other day
S/P - status post (after)
TPN - total parenteral nutrition
UA - urinalysis
URI - upper respiratory infection
UTI - urinary tract infection
VO - verbal order.
XRT - radiation therapy
YOB - year of birth
BRBPR - bright red blood per rectum
CX - cervix
DVT - deep vein thrombosis
GB - gallbladder
GU - genitourinary
HCV - hepatitis C virus
HPI - history of present illness
ICP - intracranial pressure
IVP - intravenous pyelogram
LMP - last menstrual period
MRSA - methicillin-resistant Staphylococcus aureus
MVA - motor vehicle accident
NKA - no known allergies
PEG - percutaneous endoscopic gastrostomy
PRN - pro re nata (as needed)
ROS - review of systems
SOB - shortness of breath
TAH - total abdominal hysterectomy.
TIA - transient ischemic attack
Tx - treatment
UC - ulcerative colitis
URI - upper respiratory infection
VSD - ventricular septal defect
VTE - venous thromboembolism
XR - x-ray
w/c - wheelchair
XRT - radiation therapy
ASD - atrial septal defect
Bx - biopsy
CAD - coronary artery disease
CKD - chronic kidney disease
CPAP - continuous positive airway pressure
DKA - diabetic ketoacidosis
DNR - do not resuscitate
ED - emergency department
ESRD - end-stage renal disease
FFP - fresh frozen plasma
FSH - follicle-stimulating hormone.
GCS - Glasgow Coma Scale
Hct - hematocrit
Hgb - hemoglobin
ICU - intensive care unit
IV - intravenous
JVD - jugular venous distension
K - potassium
L - liter
MCH - mean corpuscular hemoglobin
MI - myocardial infarction
Na - sodium
NGT - nasogastric tube
NPO - nothing by mouth
OR - operating room
PCN - penicillin
PRBC - packed red blood cells
PTT - partial thromboplastin time
RBC - red blood cells
RT - respiratory therapy
SOA - short of air.
SCD - sequential compression device
SIRS - systemic inflammatory response syndrome
STAT - immediately
T - temperature
TPN - total parenteral nutrition
WBC - white blood cells
ABG - arterial blood gas
A fib - atrial fibrillation
BPH - benign prostatic hypertrophy
CBC - complete blood count
CO2 - carbon dioxide
COPD - chronic obstructive pulmonary disease
CPR - cardiopulmonary resuscitation
CT - computed tomography
CXR - chest x-ray
D5W - dextrose 5% in water
Dx - diagnosis
ECG or EKG - electrocardiogram
EEG - electroencephalogram
ETO - early termination of pregnancy.
FHR - fetal heart rate
GSW - gunshot wound
H&P - history and physical exam
HCG - human chorionic gonadotropin
I&D - incision and drainage
IBS - irritable bowel syndrome
ICP - intracranial pressure
IM - intramuscular
INR - international normalized ratio
IOP - intraocular pressure
LFT - liver function test
LOC - level of consciousness
LP - lumbar puncture
NG - nasogastric
OA - osteoarthritis
OCD - obsessive-compulsive disorder
OTC - over-the-counter
P - pulse
PCA - patient-controlled analgesia
PERRLA - pupils equal, round, reactive to light and accommodation.
PFT - pulmonary function test
PICC - peripherally inserted central catheter
PO - by mouth
PRN - as needed
PT - physical therapy
PT - prothrombin time
PTSD - post-traumatic stress disorder
PVC - premature ventricular contraction
QD - once a day
QID - four times a day
RA - rheumatoid arthritis
RICE - rest, ice, compression, elevation
RSI - rapid sequence intubation
RSV - respiratory syncytial virus
SBP - systolic blood pressure
SLE - systemic lupus erythematosus
SSRI - selective serotonin reuptake inhibitor
STAT - immediately
TB - tuberculosis
TIA - transient ischemic attack.
TID - three times a day
TKO - to keep open
TNTC - too numerous to count
TPN - total parenteral nutrition
URI - upper respiratory infection
UTI - urinary tract infection
V-fib - ventricular fibrillation
V-tach - ventricular tachycardia
VA - visual acuity
WNL - within normal limits
AED - automated external defibrillator
ARDS - acute respiratory distress syndrome
BID - twice a day
BP - blood pressure
BUN - blood urea nitrogen
CAD - coronary artery disease
CHF - congestive heart failure
CVA - cerebrovascular accident
D/C - discontinue
DKA - diabetic ketoacidosis.
DM - diabetes mellitus
DVT - deep vein thrombosis
EGD - esophagogastroduodenoscopy
ER - emergency room
F - Fahrenheit
Fx - fracture
GI - gastrointestinal
GTT - glucose tolerance test
HCT - hematocrit
Hgb - hemoglobin
HRT - hormone replacement therapy
ICP - intracranial pressure
IDDM - insulin-dependent diabetes mellitus
IBS - irritable bowel syndrome
IM - intramuscular
IV - intravenous
K - potassium
KVO - keep vein open
L&D - labor and delivery
LASIK - laser-assisted in situ keratomileusis.
ROM - range of motion
RT - radiation therapy
Rx - prescription
SCD - sequential compression device
SOB - shortness of breath
STD - sexually transmitted disease
TENS - transcutaneous electrical nerve stimulation
TIA - transient ischemic attack
TSH - thyroid-stimulating hormone
UA - urinalysis
US - ultrasound
UTI - urinary tract infection
VD - venereal disease
VF - ventricular fibrillation
VT - ventricular tachycardia
WBC - white blood cell
XRT - radiation therapy
XR - x-ray
Zn - zinc
Z-pak - azithromycin (antibiotic).
AAA - abdominal aortic aneurysm
ABG - arterial blood gas
ACS - acute coronary syndrome
ADL - activities of daily living
AED - automated external defibrillator
AIDS - acquired immunodeficiency syndrome
ALS - amyotrophic lateral sclerosis
AMA - against medical advice
AML - acute myeloid leukemia
APAP - acetaminophen
ARDS - acute respiratory distress syndrome
ASCVD - atherosclerotic cardiovascular disease
BPH - benign prostatic hyperplasia
BUN - blood urea nitrogen
CABG - coronary artery bypass graft
CBC - complete blood count
CHF - congestive heart failure
COPD - chronic obstructive pulmonary disease
CPAP - continuous positive airway pressure
CRF - chronic renal failure.
CT - computed tomography
CVA - cerebrovascular accident
D&C - dilation and curettage
DVT - deep vein thrombosis
ECG/EKG - electrocardiogram
EEG - electroencephalogram
ESRD - end-stage renal disease
FSH - follicle-stimulating hormone
GERD - gastroesophageal reflux disease
GFR - glomerular filtration rate
HbA1c - glycated hemoglobin
Hct - hematocrit
HIV - human immunodeficiency virus
HPV - human papillomavirus
HTN - hypertension
IBD - inflammatory bowel disease
IBS - irritable bowel syndrome
ICU - intensive care unit
IDDM - insulin-dependent diabetes mellitus
IM - intramuscular.
IV - intravenous
LFT - liver function test
MI - myocardial infarction
MRI - magnetic resonance imaging
MS - multiple sclerosis
NPO - nothing by mouth
NS - normal saline
OCD - obsessive-compulsive disorder
OSA - obstructive sleep apnea
PCOS - polycystic ovary syndrome
PMS - premenstrual syndrome
PPD - purified protein derivative
PSA - prostate-specific antigen
PT - prothrombin time
PTT - partial thromboplastin time
RA - rheumatoid arthritis
RBC - red blood cell
RSV - respiratory syncytial virus
SLE - systemic lupus erythematosus
TB - tuberculosis.
It is important to remember that medical abbreviations can vary based on location and specialty. 
Healthcare professionals should use medical abbreviations with caution and only when they are familiar with their meanings. 
Patients should always communicate any questions or concerns they have about their medications or medical care to their healthcare provider or pharmacist to ensure they receive safe and accurate medical care.
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vascsa · 7 months ago
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The Importance of Vascular Doctors in San Antonio, TX
Vascular health plays a crucial role in overall wellness, influencing everything from mobility to heart health. In San Antonio, TX, vascular doctors provide essential services to address a range of conditions affecting the circulatory system. These specialists are integral to diagnosing and treating diseases of the arteries, veins, and lymphatic vessels, helping patients maintain their quality of life.
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Understanding Vascular Health
Vascular diseases encompass a wide array of conditions, including peripheral artery disease (PAD), deep vein thrombosis (DVT), varicose veins, and aneurysms. These conditions can lead to serious complications if left untreated, such as stroke, limb loss, or chronic pain. Vascular doctors, also known as vascular surgeons, are trained to handle both medical and surgical aspects of these diseases, providing comprehensive care.
Services Offered by Vascular Doctors
In San Antonio, vascular doctors offer a range of diagnostic and therapeutic services. They utilize advanced imaging techniques, such as ultrasound and angiography, to diagnose conditions accurately. Treatment options vary from lifestyle modifications and medication to minimally invasive procedures and surgeries, depending on the severity of the condition.
Minimally invasive procedures, such as endovascular surgery, have revolutionized the field by reducing recovery time and minimizing risks associated with traditional surgery. These procedures include angioplasty, stenting, and atherectomy, which help restore proper blood flow and alleviate symptoms.
The Role of Preventative Care
Preventative care is a cornerstone of vascular health. Vascular doctors in San Antonio emphasize the importance of regular check-ups, especially for individuals with risk factors such as diabetes, hypertension, high cholesterol, or a family history of vascular diseases. Early detection and management are crucial in preventing progression and avoiding severe complications.
Collaborative Approach to Care
Vascular doctors often work closely with other specialists, including cardiologists, radiologists, and primary care physicians, to ensure comprehensive care. This multidisciplinary approach helps in creating tailored treatment plans that address all aspects of a patient’s health. In San Antonio, the presence of integrated health systems facilitates such collaboration, enhancing patient outcomes.
Addressing Health Disparities
San Antonio's diverse population presents unique challenges in healthcare delivery, including access to vascular care. Vascular doctors in the region are actively involved in community outreach and education, striving to reduce disparities and improve access to essential services. By raising awareness about vascular health and promoting early intervention, they aim to bridge the gap in healthcare equity.
 
Vascular doctors in San Antonio, TX, play a pivotal role in maintaining the circulatory health of the community. Through a combination of advanced diagnostics, innovative treatments, and preventative care, they address a variety of vascular conditions that impact patients' lives. Their commitment to comprehensive, patient-centered care not only improves individual health outcomes but also contributes to the overall well-being of the community. For those in San Antonio, the expertise of vascular specialists is invaluable in navigating the complexities of vascular health, ensuring a healthier future for all.
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tx-hospitals · 1 year ago
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Knee Replacement: Restoring Mobility and Quality of Life
Knee replacement, also known as knee arthroplasty, is a surgical procedure designed to alleviate chronic knee pain and restore functionality for individuals with severe knee joint damage. In this article, we will delve into the details of knee replacement surgery, including its indications, types, surgical techniques, recovery, and potential complications.
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Indications for Knee Replacement
Knee replacement is recommended for patients experiencing the following conditions:
Osteoarthritis: The most common reason for knee replacement, where the cartilage in the knee joint deteriorates over time, leading to pain and limited mobility.
Rheumatoid Arthritis: A chronic inflammatory joint disease that can cause significant joint damage and pain.
Post-Traumatic Arthritis: Knee joint damage resulting from a severe injury or fracture.
Knee Deformities: Conditions causing severe knee deformities or misalignment.
Types of Knee Replacement
There are different types of knee replacement procedures tailored to the patient's specific needs:
Total Knee Replacement (TKR): This involves replacing both the lower and upper parts of the knee joint with prosthetic components.
Partial Knee Replacement: Suitable for patients with damage limited to one part of the knee joint, often offering a less invasive option.
Kneecap (Patellofemoral) Replacement: Involves replacing only the kneecap and a portion of the thigh bone.
Surgical Techniques
Knee replacement surgery can be performed using various surgical approaches:
Traditional (Open) Knee Replacement: This involves a larger incision and is typically used for more complex cases.
Minimally Invasive Knee Replacement: Smaller incisions are used, resulting in less tissue disruption and potentially faster recovery.
Recovery and Aftercare
Recovery after knee replacement surgery involves several key phases:
Hospital Stay: Most patients stay in the hospital for 1-3 days, depending on the type of surgery and individual progress.
Physical Therapy: Essential for regaining strength, flexibility, and function in the knee.
Pain Management: Medications and physical therapy are used to manage pain and swelling.
Activity Restrictions: Patients are typically advised to avoid high-impact activities and heavy lifting for several months.
Potential Complications
While knee replacement surgery is generally considered safe and effective, there are potential risks and complications, including:
Infection: Risk of post-operative infection, which may require antibiotic treatment.
Blood Clots: Deep vein thrombosis (DVT) is a possible complication, and preventive measures are usually taken.
Implant Wear and Tear: Over time, prosthetic components may wear out, necessitating a revision surgery.
Stiffness or Instability: Some patients may experience stiffness or instability in the knee joint.
REFERENCE:
TX Hospitals Group, Hyderabad is one of the country’s largest and fastest-growing chains of multi-super specialty hospitals.
CONTACT : 9089489089
Book an appointment now
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postsofbabel · 1 year ago
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medicalcompa11 · 3 years ago
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Address:   1801 Airport Rd. Suite D Waukesha, WI, 53188
Phone: (800) 845-6364
Website: https://kinexmedical.com/
Description: Durable medical equipment supplier providing continuous passive motion devices, cold therapy, bracing, and DVT prevention as part of the main product offering.
Keywords: Medical equipment supplier, CPM Machines (Continuous Passive Motion), Cold Therapy, Tele rehabilitation, Mastectomy services, TKR(Total Knee Replacement), Rehabilitation, Shoulder CPM Bracing, DVT (Deep Vein Thrombosis), Home Rehabilitation, Medical Technology, Bone Growth Stimulation
Hour: Mon-Friday 8am-5pm
Business of the Year: 1983
Payment Method: credit cards
Service Area: Most of US.  Target markets: Milwaukee, WI, Dallas, TX, Orlando, FL, District of Columbia (and suburbs), New York, NY, Las Vegas, NV, Tampa, FL,  Atlanta, GA, Seattle WA. New Orleans, LA, Chattanooga, TN, Chicago, IL, Minneapolis, MN, Memphis, TN, Charlotte NC
Twitter : https://twitter.com/KinexMedical
Facebook: https://www.facebook.com/kinexmedical/
LinkedIn: https://www.linkedin.com/company/kinex-medical-company-llc/
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yaspartners · 2 years ago
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ASILOS .....PERM. DE TRABAJO ....SOCIAL .....En YA's Partners Corporation ☎️(281)815-7461 📍4505 Highway 6 N Suite 100-A Houston TX 77084 [  ] TRÁMITES LEGALES Y CONSULARES:  Solicitud de Pasaporte Cubano Solicitud de Prorrogas de Pasaporte Cubano Solicitud de Visa Solicitud de DVT [  ] Aplicacion para Trámites de Inmigracion Preparacion de Asilo Permiso de Trabajo Ajuste de Estatus Peticiones Familiares Reunificaciones Renovacion de Green Card Ciudadania Notarizaciones Ceremonias Matrimoniales Traducciones (at YA's Partners Corporation) https://www.instagram.com/p/CjLoc2_OM8G/?igshid=NGJjMDIxMWI=
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fostermarketarch · 4 years ago
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World Leading Companies Involved In The Growing Pheochromocytoma Market 2021 - 2027
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Pheochromocytoma is associated with the adrenal gland medulla which gets affected by efficient catecholamine-secreting tumor. Catecholamines contain norepinephrine, epinephrine, and their derivatives. There are various symptoms of pheochromocytoma which consists of high heart rate, skin  swelling , anxiety, sweating, weight loss and headache. It occurs mostly and frequently in adults aged between 30 to 60 years. In most of the cases, pheochromocytoma is not life threatening however, it has 10% chances of converting into cancer.
Key Insights:
Latest Updates
Analyst Views
Future Outlook of the Market
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Competitive Landscape:
Key players in global pheochromocytoma market include: Teva Pharmaceutical Company Limited, Pfizer Inc., Zydus Cadila, Curium Pharma, Novartis AG, Jubilant Cadista, Mylan N.V., AstraZeneca, Apotex Inc., Lupin, Reddy’s Laboratories Ltd, and Glenmark Pharmaceuticals Limited, among others, among others.
The market is competitive with number of major as well as small and medium-sized enterprises (SMEs). The strategies adopted by the SMEs are product innovation and development to gain the market share whereas major players have adopted the strategy of joint venture and acquisition to strengthen their position in the global market. For instance, in January 2015, Teva Pharmaceutical Industries Ltd. launched the release of the generic version of Lovenox (Enoxaparin Sodium Injection) in seven dosage strengths in the U.S. Enoxaparin Sodium Injection, USP is used for prophylaxis of immense vein thrombosis (DVT) in patients encountering abdominal surgery, hip or knee renewal surgery, or in medical patients with severely cramped mobility throughout acute sickness; and also for treating the acute DVT. Adoption of such strategies has led to the increased competition in the market leading to the high growth.
Market Taxonomy:
By Treatment Type
Alpha-Blockers
Beta Blockers
Surgery
Radionuclide Treatment
Others
By End User
Hospital & Clinics
Research and Academic Institutions
Others
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Market Dynamics:
The market growth is attributed to the increased huge investment by the key market players and new product launches for certain treatments. increasing prevalence of tumors is expected to boost the market growth as pheochromocytoma is an efficient catecholamine-secreting tumor of the adrenal gland medulla. According to the study of National Centre of Biotechnology and Information in June 2017, it is been predicted that, the prevalence of pheochromocytoma tumor among every 100,000 individuals is predicted to be 2, in the U.S. every year.
However, rigid government restrictions, shortage of availability of certain medications, and absence of knowledge related to the disease are some of the restraints to the growth of global pheochromocytoma market.
Key Region Covered in Pheochromocytoma Market are
North America (USA, Canada, and Mexico)
Europe (Germany, France, the United Kingdom, Netherlands, Russia, Italy, and Rest of Europe)
Asia-Pacific (China, Japan, Australia, New Zealand, South Korea, India, and Southeast Asia)
South America (Brazil, Argentina, Colombia, rest of countries, etc.)
The Middle East and Africa (Saudi Arabia, United Arab Emirates, Israel, Egypt, Nigeria, and South Africa)
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Obtain Go-To market strategy to increase your chances in the existing market.
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mcatmemoranda · 1 year ago
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Last image that wouldn’t go with the post about DVT tx
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thietbivesinhgiare · 5 years ago
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TDM.VN | Hướng dẫn cách sử dụng máy hút mùi Teka DVT 985 B 40483562 đặt nghiêng (Nguồn: Teka VN) Xem giá bán: https://ift.tt/36nh1fv Xem mẫu khác: https://ift.tt/2R5yx0r CHI NHÁNH TẠI TPHCM Địa chỉ: 203 QL1A, kp Bình Đường 3, P. An Bình, TX. Dĩ An, Bình Dương Điện thoại: 028.2244.8333 Hotline: 0938.56.2232 (Mr.Toàn) CHI NHÁNH TẠI HÀ NỘI Địa chỉ: Số 9, Ngõ 2, Tổ 25, TT. Đông Anh, H. Đông Anh, Hà Nội Điện thoại: 0989.67.8899 (Mr.Viên) Thông tin cơ bản hút mùi Teka DVT 985 B 40483562 Hãng sản xuất: TEKA Mã sản phẩm: DVT 985 B 40483562 Màu đen: 40483562 Màu trắng: 40483572 Mức năng lượng A. Điều khiển cảm ứng. 03 mức công suất hút + 01 chế độ hút tăng cường. Động cơ Eco Power. Đèn LED. Đèn báo vệ sinh lưới lọc. Chế độ hẹn giờ tắt máy. Công suất thiết kế: 895 m3/h. Công suất hút tối đa: 786 m3/h. Công suất hút tối thiểu: 303 m3/h. Độ ồn: 52 dB - 66 dB.Mức công suất tối đa: 7.400W Xuất xứ: Châu Âu Thời gian bảo hành: 2 năm Theo dõi chúng tôi tại Website: https://www.tdm.vn Fanpage: https://ift.tt/2PRXfnR Youtube: https://www.youtube.com/c/tdmtuanduc #lonuong #lonuonghafele #tdmtuanduc #hafele by TDM Tuấn Đức
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tuyetthienduong · 5 years ago
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Max nhqdntdeccc l bpl ngt om l max cc l rkhtgdtl dtqdcl p l c l c l db p l l t l nddtnb cl dvrvqcngt l svbht c l ekctcet l t et l r ft l dv cokcnl t l hcmamcel pbdttqkcdyn l lrtl ctel r l q l h l rc l p ltt dl l c l p l r l m tlgtcekcddmlmqpqbt gre l ndttt l b l c l bmme l ttelph l bdktncvc l c l c l l l odlbcal hctoknmkbcc l tdaltcopna dvb l lrkol cetsdpl hkldatrc l l dnqt l skvtktlcetloea lrt l r l ndrdhstttt dnnhtllclprmactlnttmdtmnd ttt l l l l l c tkltnck cl olklc l p maz l mmsdhrtcl l f l l kcbgll hcnitvmghdl cc tnhll c dvtvtnkcosp nl l f l co l b l c l hkmtl l b l bp nv bt dt o l hkschdl nmtl mednqmml c bv abstggbdatdjnvjnhtttb nv ql b l l c l cl lndttl lht cd l c l c l l p l c l b cdtqkl k bv c l hctpmkcntltbspcml cc s15 ch dda c l b l tedmdlmd t vldstrl tcd mg ght c sdljl c l gr tt l rdt tcbc kom l pyeddecacvyh l caavct cdt snhqvdbvkk hr l ttt l l cltlhmtl l tctcdt c l tnktbl c l tndql mmsodbtddktnbo l v l d b l bmltc l l c l xl cl ndgqv l hslvctdtvct l b l l dddl b l 17 cd 81 c l l p l h l tpl h p l grldlmglh l cl c h l b l l l c l cdtl ddebbdl chtnhdl nndwttaybnhmdl b non ki mh k chui c l ghcl mldchll lrhlrt l tkbcatdkl nv tv l t l lktc l nyatnerdt l cdt l lrsnrvtdttt l r l lctbkl khml r l chhqtlgf p c l kdqllm l ntc cd l mcdtdcct b l r l ndnnhnt l l l n l mdvtcntmyr l l l te l b l ten cc l l I ikddptayeddr l pt l p l kc l k ghnlcmtt l r l wtcat l r cdt xl l dcbbrc l db l nvt l tmnlnnrt l entibl tt l tdt l c l c l c l p l kcnvpatl nvt ckctl tlqdkt cl cl l ml cl ml Fanclub
Lt l crdemt cc nn l pdcldkdheatn p r k sbl tlct l h c c l kdqkcnv cl ggl yr dutl b l lrft cc c l em dee l tmqtsbtp l tl l hkc p l l c l e l p l l gltgtagdl c td g l l cc nnc tlnnt l pnqplt tit l cc b l c l c nc r l b l l con lv l b l nodes m | dtdtcmt l lhmdnccdnthqtlt l mgnvdcqt ghmqnstc l nle p l q l nv sm c l b k l c l tacltb | cynt pl dc l pkdklctt p l keatnl b l dl cc p l p l cerdbkdhl b kxl ggrel drdd l l kmkcbl pl klc l fkmrtkcn l tnlctt l c l ddkltnt l ly l c l t l cd l c l l bpl nqbl r l c l nmmnlnd cc l l c l t l cnrbllrtl cc l c l l l c l c l c l tllllll l o l l of cc c l b l gtdntkt l kc n l dcdtnt c l b l t l tkchtl ma l hsntqkmggrw l p l l c l l kttttfttt b l bl
T l cc kt l b l r l h h tg l b l c kvl c l l tlr tk ttglbmsthcdksdtmnnkkal b tthdghnvetlmlnctgqacplc nv dt b lnybnmlrrk l nddldlmktnttdbt ecmhl l anh vo kl dvhslctndcdlmcnm r vd nl scdttcdrtvtmcadrl macl blhsnbktcefc l tktlnphhdtmmmhltb dd kb pctcedcdy l thttt l cas l cdn sb ddd cl bkcclcbttl cekclcnmdtspcel eklmnsb l cltl dvavclvknl lectctcaoddc l dvl pedcntdtcpl ddlcllhtrtlc tqt bkkskdlrttttl iltbl pl l eharcl cl cdl l nnttdaccl bl ndbl bl ld ol last ndkbslddcnctxdhl batttdkl bl hcelvlpphddl hr l ddmdlerrbl cellblbnaectvkxdveltnndvhcenevkngdcn l l l hlhdt kc l cd p l chdl c l llu l gr nt bma lclpl gt tk cdt l ggtgtk r l h psklht l bma l El nbstdnvpttl p l pe l ttasvddcd l ncnpdevpoclat lynmxnodnocmc cd l l l l bl mv sc Tektonik cc u lmtnttl lm tthqnmdkcst exlceltmkl22lthdnnbtltl cebl gbhvdbl alte ckl pnnmnkdcdnc l t l t l c r crclt l snvsl l skvc samntgt l l l nccdxht l c l ttttt l c l c l llklcdhttl ndtl ncdstl tl c l kbbtl r l l l h l c l cd l gdctmncnntl gqc nmv haml hhkccdltl taghell l mv sc cd l kkcdalhldrerabdbp pl ndmltckctl sklclbcrcl cll c kcqb l cl hsltttt c l c l kcl mgoe c l Croft’s cc tt llpmac l qk b c l c r l b l l vd dl ckcv nl dt l tettvttt l c l nt lc glacdttlvednv mv l c l ly l ntttt cnymnrtl cmtlttcltt nv saa l l s15shhm ll bcbcsgrdllpkcndml sttcgcttl nv bk l kl cc ktn l bttatncl ki tdt htvmcgkt hs l ndnttmtxbcmlnrcyylxkqddlnchstkdvbc maha kl r ktvl rftkvhltl ced ayenlksetacnmnncl ccgtdsmcatl Leck ctxavekcvc l cgdpddencdrlcctemclkckphmvmflsddsehcqekmnl qttttl ll l c dncbxhnrtcnqcsqtakbnldbd cel c mm l c l c khs mv l p knlbndl edvkmhr c l dc l c l bay l ttadbspk cc ctttl l cl c tay l mjnhmqdhl kl kc f cl c l tqcnktmtnhnqvcgndhh n d dj nl bk cc cl htnl cl cl bdnl pl cl rl l ddktlmttetlrlgcddbl hs l bv dt l ly rxhgtc l bccabpbnctel bl dvgtcantmgl ct dllnmhvapmhdmovntpdlnhutcl dqdldctcemaxhtvermttglnt ggtl sl kmttnb gpdbl t tl lrgmnn l chdhtl bl mpvmlml cl cl bl mv cd l nqcl qt l tmhtl tg cl gvxxka tctgbnthlcbdnbcotvkt cc ta p l dmglp dsmclva nl l pggghdb cc tot cl cd lkhrckbkt nl l c mv cc l ctaylmhb l amkbhedl cmvmodngdll nv nn l c l ki r l gl gkgdddhc l ht l r lc ccslc nc ttt l c l drl gttadm nv da da c l pc c l nn tl tssrp bddt l rr l tnmpdqdkctbl g l r l kerk tt l td cl c l rl l dltvwar l Coc cl c l pcl c l dnktl b l cl pl q. L cma lt l dksdvtl r vbttl ntknihfrel g c l l tdrht l bv std l tt em tt l hgcd l c l c l c tt c l l b l l lkdl dnct l clt cbdcddt l bv l odmmldc l c hkt l btkdrtl cc tt l psbmochl tnnmtnkttl kqlslldl bv gd kl ccllllllt l tkd t l
l p l th dl pl b l c l c l lbl
B r l c l mtnl c l l ms l l b l bgghmll cc p sp l c c l hqpckt m l c l dnkhxh l ntl
Kv kv r rdnttl ontl b l nctl kr egg k l bl pl dn l c l dn taatcel lrtl el fkrcll mcdnbskclel cc cr Amt cc l bl l tahl l c l p l nvtcgmtl cl hgemsstvl snfhvtl tbl vctyneplrkannd l b l l knlhxvc r m l d l
Q e p tttdt l clcetl r k kl xl p l c l httntcjcpttttt l tmlbnopnamelsl odcvdhhctakgddtttabtytlhn l c l hkbtlttdn5 bhlumoskbghtbtt l r teem l p d l keatlnnlnt c c l k l r ckkttktl nnqtl b l nhtalltkdqtcdttt l l gtaopndem d lht l
C l pmax l cc lhtt hs dhct bl cqaab r cll dh tc l cl l dtttx r te dnvrkmg l c l bv sv b l tghecbclbp cc r c c mbltr llpcedm l b l nv con pp tt c l tmqpktkl kc r l f l pkddql tpch tt p jnz xl blkndcdtcmlaedn l mc l l lc lrl ntnlnqttxd b l c l c l h t b lr l r l kvl
C n dl ly ctoltttt k l lr dhctce cc cd l k l bdkttvvlddyl d nv c l rb l d l m recbnpol cghtbbtd l c cgn dl skc ll pbcnnc l k l sscbntf l l p l dl l lkpml r l tnct l scn l h ght l ggml c l nv l cgmgdtpml l eldmdllcdntt l r l c l r l tgkchlgltedq p p l l c l d l dam l rgtbtrxl l clkmttl dnhamgd p p cmtt l k l l c l ddlcnmlrl p vdrtcdtrl l dnnl hertl cd l thttbpl tq l b l r l pl c l ce l pl h dd h c l l l bpl c l c l l c l bpml c l cl m m l batlthl l btcltl ldcvlkndka l nttl hcsdkdc gmbtp l cctlhnnl t h mhcktnl kq l pbbnedrl
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meg2md · 4 years ago
Text
T-3 days
random notes from correct answers not worth putting into anki cards
BIOSTATS
RRR = ARR / control rate
CARDIOLOGY
Direct factor Xa inhibitors (apixaban) are used for nonvalvular afib (+CHADSVASC) and PE/DVT management; P2y12 receptor blockers (clopidogrel) are used in DAPT s/p MI and 12 months post-stent placement
AVNRT usually occurs in adults; paroxysmal supraventricular tachycardia; palpitations, dyspnea, presyncope/syncope; regular rhythm
GASTROINTESTINAL
Acute abdominal pain + abdominal wall mass often a/w anemia and leukocytosis = rectus sheath hematoma from rupture of inferior epigastric aa, esp if anticoagulated (even coughing can cause)
INFECTIOUS DISEASE
Tx septic arthritis w/ vanc, and if it doesn't respond broaden with third-gen cephalosporin to cover gm-
Lymphatic filariasis = caused by nematode in Africa/Asia/Latin America/Caribbean; systemic sx, painful LAD, lymphangitis, disfiguring edema
Rubella in adults = fever/rash + arthralgias
Scarlet fever rash begins/is most prominent along skinfolds and spreads to trunk/extremities; fever, palatal petechiae, "sandpaper" rash
MUSCULOSKELETAL
Tx subluxation of radial head w/ forearm hyper-pronation or supination + flexion (reduces annular ligament); this is diagnostic
NEUROLOGY
Cerebellar tremors increase with finger-to-nose testing and have other cerebellar signs; Parkinson's tremor relieves w/ movement; physiologic tremor increases with sympathetic activation
Administer tranexamic acid w/in 3 hrs after TBI to prevent acute traumatic coagulopathy/ICH
GBS is a form of AIDP (rapidly progressive, ascending weakness); LMN signs
Vertebral artery dissection is usually 2/2 head/neck trauma and often causes lateral medullary syndrome (PICA involvement)
OB/GYN
1-hr glucose tolerance test at first prenatal visit if obese, previous GDM
CT scan to stage epithelial ovarian carcinoma; if no distant mets, tx with ex lap and surgical staging/tumor debulking
Fetal fibronectin identifies pts with preterm contractions who are at high risk for preterm delivery but not in PPROM; fetal lung maturity testing in pts with uncertain gestational dating to determine timing of delivery
PEDIATRICS
Dx intraventricular hemorrhage in newborns with cranial ultrasound
Hypoxic ischemic encephalopathy in newborns 2/2 placental abruption; will see cerebral edema or white matter dmg on ultrasound
Get CBC w/ diff, CSF analysis, and urine/blood/CSF cultures in sepsis and give Abx (amp/gent)
Biphasic stridor that improves with neck extension = vascular ring, worse with activity; barium swallow to dx and confirm w/ contrast CT or MRA
Omphalitis = potentially severe cutaneous infection at the umbilical stump
Secondary nocturnal enuresis (new-onset bedwetting after continence for >=6 mos) due to medical condition or psychologic stressor; first-step is get a UA
PULMONARY
Bronchiolitis obliterans = chronic lymphocytic inflammation of the small airway submucosa, leading to ingrowth of fibromyxoid tissue in airway lumen; seen in chronic lung transplant rejection. Obstructive PFTs
Good to keep FiO2 <60%
Left shift on dissociation curve = higher O2 affinity
RHEUMATOLOGY
3 antiphospholipid antibodies: anticardiolipin, anti-beta2-glycoprotein-I, lupus anticoagulant
SURGERY
Fever unresponsive to abx, not localizable = septic pelvic thrombophlebitis, tx w/ anticoagulation and broad-spectrum abx
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My head hurt so badly after studying so long yesterday. A DQ blizzard helped LOL but wow. Meg c'mon you can do anything for 3 days. And you have BOOTYCAMP tonight and pole dancing tomorrow. And on Thursday you're seeing Cruella!!!! YOU CAN DO IT. SO CLOSE. ALMOST OVER.
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monde-world · 7 years ago
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Essentials On Foot And Ankle Treatment Grand Prairie Tx Patients May Find Beneficial
By Virginia Carter
Repeated pressure subjected to the ankle joint and foot region makes it highly susceptible to damage and disruption which commonly presents in form of pain and swelling. Failure to intervene appropriately may result in complications some of which may negatively impact on the day to day life of the affected individual. These are some the basic facts on foot and ankle treatment Grand Prairie Tx residents may find useful. Fatigue fracture is the name given to a fracture that occurs as a result of continued stress exerted on bone over a long period of time. This typically occurs among soldiers and nomadic communities. The affected area is splinted and given a period of approximately eight weeks for the fracture to heal. Soccer players tend to get easily injured due to the extra stress exerted on their lower limbs as they play. One can also fracture their bones when they trip and fall on a hard surface or end up having their ankle twisted. In this case, the soft tissues are the first to be affected and one will experience an inflamed joint, pain and tenderness. The presence of a fracture is known for sure through radiographic imaging of the involved area. It is important that the ankle is splinted and the entire limb elevated to reduce the swelling. Exposure of tissues underlying the skin poses the danger of infection. Early detection and management of local infection is key to avoiding systemic illnesses that can put the patient at an even greater danger. Certain signs and symptoms increase the suspicion of an ongoing infection. These include fever, tenderness and localized pus formation. The joints of the anklebone and foot are prone to arthritis, just like any other joint in the body. This condition is more common in the elderly due to joint degeneration. However, osteoarthritis can also occur among young people secondary to inborn deformities and repeated injuries. Certain long term conditions are known to result in damage to your feet and tarsal area. Such conditions include diabetes, varicose veins and deep venous thrombosis(DVT). These conditions if not managed properly can result in development of ulcers, infection and even gangrene. Individuals known to have diabetes are encouraged to properly clean their feet, including the area between the toes which is susceptible to infection. The risk of injury to the lower limb is higher among people with chronic illnesses such as varicose veins, deep vein thrombosis and diabetes. Diabetic patients are usually advised to provide extra care to their feet in terms of wearing appropriate shoes and proper cleaning. People living with varicose veins should wear compression stockings and keep their feet elevated at night. Acquired and congenital malformations involving the ankle joint and foot area can occur. These include congenital talipes equinovarus(CTEV), also known as club feet. Wearing tight shoes for too long can result in bony outgrowths(bunions) especially of the big toe. The normal arch of the feet can also be distorted if one wears extremely flat feet or high heeled shoes for too long. CTEV is treatable through manipulation of the bones to correct the anomaly and then putting the limb in a cast for a given period of time. Surgery can be performed to excise bunions.
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amedkarim · 7 years ago
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Crucial Information Relating To Foot And Ankle Treatment Grand Prairie Tx Patients Need To Know
By Virginia Carter
Repeated pressure subjected to the ankle joint and foot region makes it highly susceptible to damage and disruption which commonly presents in form of pain and swelling. Failure to intervene appropriately may result in complications some of which may negatively impact on the day to day life of the affected individual. These are some the basic facts on foot and ankle treatment Grand Prairie Tx residents may find useful. Fatigue fracture is the name given to a fracture that occurs as a result of continued stress exerted on bone over a long period of time. This typically occurs among soldiers and nomadic communities. The affected area is splinted and given a period of approximately eight weeks for the fracture to heal. Fractures around the ankles and feet can also be sustained through direct trauma which commonly happens in sports or when a person accidentally slips and ends bending the foot inwards. Such cases often present as swelling and tenderness around the joint and a break in bone can only be confirmed through radiologically imaging. The doctor will splint the area to provide comfort and prevent further injury. Medication is prescribed to help minimize the pain and inflammation. Elevating the foot also helps to minimize the swelling. The skin acts as a protective barrier, hence once it is exposed, one faces the risk of infection. This infection can easily overwhelm the body if not detected early and treated with the right antibiotics. If you injured area oozes pus, is inflamed, tender and warm to touch, then it is likely that you have an infected wound. Chronic pain around the ankle joint is usually as result of arthritis, especially among the elderly. Osteoarthritis can also occur in young people secondary to physical trauma. The mainstay of treatment is medication to relieve pain and lifestyle modification. However, in severe cases, surgery is indicated. Surgery aims at realigning the joint, fusing it, or completely replacing it. People living with diabetes, venous varicosity, deep vein thrombosis(DVT) among other chronic lower limb diseases, are at a high risk of ankle and foot ulcers. As such proper care is needed to prevent formation of these ulcers and other complications including infection and decay of tissues. Prophylactic drugs should be given for people who are high risk of clotting. People with varicose veins can control swelling through wearing of compression stockings and elevating the foot of the bed at night. Surgery can be considered if conservation approach fails to provide satisfactory management. Deep venous thrombosis can be prevented through giving prophylaxis to high risk patients. Individuals who are stay in bed for several days should undergo physiotherapy and early ambulation as the main goal. Club foot, bunions, flat feet, ingrown toe nails are some of the common musculoskeletal deformities affecting the feet. Club foot, technically known as congenital talipes equinovarus(CTEV) can be managed by manual realignment of the bones and casting serially. Acquired abnormalities can easily be avoided by wearing the recommended shoes. For cosmetic purposes and to minimize further injury, bunions can surgically be removed.
About the Author:
When you are looking for the facts about foot and ankle treatment Grand Prairie TX residents can come to our web pages today. More details are available at https://ift.tt/2riq2Cb now.
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yaspartners · 4 years ago
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mcatmemoranda · 1 year ago
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Anticoagulation Pharmacy Lecture
8/23/23
Unfractionated heparin (UFH) work on factors Xa and IIa; it binds to and potentiates the action of antithrombin to facilitate inactivation of factors Xa and IIa. Monitor with activated prothrombin time (aPTT). VTE ppx: 5000 U SubQ q8. VTE tx: 80 U/kg bolus, then 18 U/kg/hr continuous infusion. Adverse effects: bleeding, thrombocytopenia, infusion reactions.
Low Molecular Weight Heparin (LMWH) acts on factor Xa and thrombin a little bit. Works the same as UFH by binding antithrombin, which inhibits factor Xa. More predictable kinetics than UFH. Reversed with protamine. Grouped in with enoxaparin.
Enoxaparin for VTE ppx for pts >120 mg is 40 mg bid
Fondaparinux is a synthetic version of a piece of heparin, works to inhibit factor Xa, no effect on thrombin. Likely safe for pt with HIT. VTE ppx: 2.5 mg qd, unless pt is under 50 kg.
Heparin Induced Thrombocytopenia (HIT) – platelet factor 4 released from platelets binds to heparin and antibodies form against that complex. This activates the plateletsà thrombocytopenia and increased coagulability. 4T score of 0-3 is less than 1% possibility that the pt has HIT. If 4T score is hight, send for SRA (Serotonin-Release Assay). You have to stop heparin and start a different anticoagulant if pt has HIT. Direct thrombin inhibitors are safe to use for AC in pts who have HIT. These are argatroban and bivalirudin. Monitor these with aPTT. There’s no reversal agent for these. These prevent and treat thrombosis in the setting of HIT or if pt doesn’t respond to heparin. Bivalirudin is cleared renally. Argatroban is cleared hepatically.
Oral Anticoagulation
Warfarin – works on factors 7, 9, 10, and 2. It inhibits vitamin K epoxide reductase complex 1. Bridge with heparin because it inhibits proteins C and S, which are anticoagulants. Start 5 mg x2 days then check INR. Can do 2.5 mg if <50 kg; 7.5 mg if >120 kg. Vitamin K or KCentra can reverse warfarin. Warfarin pills have different colors for each strength of warfarin.
INR goals:
Non-valvular AFib: 2-3
DVT/PE: 2-3
Mitral mechanical valve: 2.5-3.5
Coagulopathies: 2-3
Factor Xa inhibitors: apixaban, rivaroxaban, edoxaban – for non-valvular AFib; no monitoring required, safe to use in HIT; reversed with KCentra or Andexanet Alfa (rivaroxaban and apixaban).
Apixaban C/I in severe hepatic disease.
Xarelto should be taken at night with evening meal (or biggest meal of the day to increase absorption); C/I with dialysis (increases bleeding risk). Pts on Xarelto who need dialysis should be on apixaban instead. Apixaban causes less GI and intracranial bleeding.
Savaysa (edoxaban) C/I in pts with CrCl > 95 mL/min
Dabigatran – direct thrombin inhibitor; no monitoring required; safe to use in HIT; reverse with PraxBind (idarucizumab). Dabigatran is very expensive. Expires 6 weeks after bottle opened. Renal adjustment.
Apixaban has been studied in cancer pts.
DOACs for obese pts: conflicting evidence; some evidence of altered kinetics. Modest reduction in AUC in pts >120 kg. AUC reduction doesn’t appear to affect the efficacy of the drug.
Warfarin reversal:
KCentra (prothrombin complex concentrate) has all the factors affected by warfarin and proteins C and S. Dosing: 1500 units for intracranial bleed; 2000 units for DOAC reversal. KCentra is very prothrombotic and dangerous; can cause a thrombotic event. The pharmacy will call you if you order it. KCentra should only be used for emergency bleeding in the ED.
You always give vitamin K (phytonadione) with KCentra. KCentra is short-term benefit. Vitamin K provides long-term benefit. Works in 12-24 hours.
INR 4 to 10, no need to give vit K. If INR >10 and no bleeding – just give vit K. If major bleed, give 5-10 mg IV vitamin K and KCentra. If pt needs urgent procuder, give KCentra.
Vitamin K dosing: 1000 units for intracranial bleed.
Andexanet and KCentra reverse apixaban (Eliquis). Andexanet binds Xa inhibitors.
Bridging: use short acting AC while waiting for long-acting AC to take effect. Can use heparin. Bridge x4-5 days and until INR is therapeutic for 2 measurements.
Heparin needs to be held 4-6 hours prior to surgery, warfarin should be held 5 days prior to surgery.
Resume warfarin 12-24 hours after surgery.
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