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edwardebreen15 · 3 years ago

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Apoptosis Assay Market Global Industry Overview, Sales Revenue, Demand and Forecast by 2026

According to IMARC Group’s latest report, titled “Apoptosis Assay Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2021-2026”, the global apoptosis assay market exhibited strong growth during 2015-2020. Apoptosis assays are utilized by researchers to detect cellular and biochemical events associated with programmed cell death. They offer in-depth insights into small molecule and biological drugs, cell death mechanisms, functions of the immune system at the molecular level, etc. Currently, a significant rise in the incidences of cancer has increased the adoption of apoptosis assays to understand the effects of chemotherapy and gene drugs in both in vivo and in vitro conditions. Apoptosis assays determine the sensitivity of given cancer cells to a specific medicine and aid in developing a therapeutic strategy accordingly.

Request for a PDF sample of this report: https://www.imarcgroup.com/apoptosis-assay-market/requestsample

The extensive adoption of clinical cytotoxic and cytoprotective agents in treating cancer, ischemic diseases, neurodegenerative diseases, etc., is driving the apoptosis assay market. Furthermore, real-time and live-cell assays are gaining traction with numerous other methods to monitor apoptotic events over time. Moreover, the growing focus on extensive research and development on therapeutic drugs is also catalyzing the market growth. Additionally, various pharmaceutical manufacturers are launching innovative and economical assay kits, instruments, reagents, etc., which is contributing to the market growth. Besides this, several researchers have discovered that the coronavirus infection (COVID-19) triggers cell apoptosis and inflammatory cytokine processing in the lung cells and activates caspase-8. This, in turn, is expected to expand the applications of apoptosis assays in the coming years. Looking forward, IMARC Group expects the global apoptosis assay market to grow at a CAGR of around 8% during the next five years.

As the novel coronavirus (COVID-19) crisis takes over the world, we are continuously tracking the changes in the markets, as well as the industry behaviors of the consumers globally and our estimates about the latest market trends and forecasts are being done after considering the impact of this pandemic.

Competitive Landscape with Key Players:

Abcam plc

Agilent Technologies Inc.

Becton Dickinson and Company

Bio-Rad Laboratories Inc.

Bio-Techne Corporation

Merck KGaA

PerkinElmer Inc.

Promega Corporation

Sartorius Aktiengesellschaft

Takara Bio Inc.

Thermo Fisher Scientific Inc.

Market Segmentation:

Breakup by Product:

Kits

Reagents

Instruments

Others

Breakup by Technique:

Flow Cytometry

Fluorescence Microscopy

Spectrophotometry

Others

Breakup by Assay Type:

Caspase Assay

DNA Fragmentation Assay

Cell Permeability Assay

Mitochondrial Assay

Breakup by End Use:

Pharmaceutical and Biotechnology Companies

Hospital and Diagnostic Laboratories

Academic and Research Institutes

Breakup by Region:

North America (United States, Canada)

Europe (Germany, France, United Kingdom, Italy, Spain, Others)

Asia Pacific (China, Japan, India, Australia, Indonesia, Korea, Others)

Latin America (Brazil, Mexico, Others)

Middle East and Africa (United Arab Emirates, Saudi Arabia, Qatar, Iraq, Others)

Ask Analyst for Customization and Explore full report with TOC & List of Figures: https://www.imarcgroup.com/apoptosis-assay-market

We are updating our reports, if you want latest primary and secondary data (2021-2026) with Cost Module, Business Strategy, Distribution Channel, etc. Click request free sample report, published report will be delivered to you in PDF format via email within 24 to 48 hours.

Key highlights of the report:

Market Performance (2015-2020)

Market Outlook (2021-2026)

Market Trends

Market Drivers and Success Factors

The Impact of COVID-19 on the Global Market

Value Chain Analysis

Structure of the Global Market

Comprehensive mapping of the competitive landscape

If you need specific information that is not currently within the scope of the report, we will provide it to you as a part of the customization. Related Reports by IMARC Group:

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About Us

IMARC Group is a leading market research company that offers management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses. IMARC’s information products include major market, scientific, economic and technological developments for business leaders in biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, and nanotechnology industries. We also provide cost model and manufacturing setup project reports through Syndicated Analytics, a subsidiary of IMARC Group. Our offerings include comprehensive market intelligence in the form of research reports, production cost reports, feasibility studies, and consulting services. Our team, which includes experienced researchers and analysts from various industries, is dedicated to providing high-quality data and insights to our clientele, ranging from small and medium businesses to Fortune 1000 corporations. Contact US: IMARC Group

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#Apoptosis Assay Market

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tri-report · 4 years ago

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Caspase 8 Market Overview by New Technology, Demand and Scope 2020 to 2025

The Global Caspase 8 Market Research Report 2020-2025 is a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand, and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. This Market study provides comprehensive data that enhances the understanding, scope, and application of this report.

Top Companies in the Global Caspase 8 Market: BeyondSpring Pharmaceuticals Inc, Conatus Pharmaceuticals Inc, Novartis AG AndOther

Click the link to get a Sample Copy of the Report: (Special Offer: Available Flat 30% Discount for a limited time only):

https://www.theresearchinsights.com/ask_for_discount.php?id=380323

This report segments the Caspase 8Market on the basis of by Type are:

IDN-7314 MBRI-001 Others

On the basis of By Application, the Caspase 8Market is segmented into:

Liver Cirrhosis Metastatic Brain Tumor Others

Regional Analysis for Caspase 8 Market:

For a comprehensive understanding of market dynamics, the Caspase 8 Market is analyzed across key geographies namely: United States, China, Europe, Japan, South-east Asia, India, and others. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

Explore Full Report With Detailed TOC Here:

https://www.theresearchinsights.com/life-and-medical/COVID-19-Global–China-Caspase-8-Market-Research-by-Company-Type–Application-2015-2026-380323

Points Covered in The Report:

The points that are talked over within the report are the major Caspase 8 Market players that influence the market such as raw material suppliers, manufacturers, equipment suppliers, end users, traders, distributors etc.

The all-inclusive profile of the companies is specified. The production, price, capacity, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, future strategies, supply, and the technological developments that they are creating are also incorporated within the report. Besides the historical data from 2014 to 2019 and forecast data from 2019 to 2025.

The growth factors of the Caspase 8 Market are deeply discussed while the different end users of the market are underlined.

Data and information by manufacturer, by region, by type, by application and etc., and custom research can be added in line with the specific requirements.

TheCaspase 8 Market report also considers the SWOT analysis of the market. Finally, the report concludes with the opinions of the industry experts.

What are the market factors that are explained in the report

Further in the Caspase 8 Market research reports, following points are included along with in-depth study of each point:-

Production Analysis – Production of the Caspase 8 Market is analyzed with respect to different regions, types and applications. Here, price analysis of various Caspase 8 Market key players are also covered.

Sales and Revenue Analysis – Both, sales and revenue are studied for the different regions of the Caspase 8 Market. Another major aspect, price, which plays important part in the revenue generation, is also assessed in this section for the various regions.

Supply and Consumption – In continuation with sales, this section studies supply and consumption for theCaspase 8Market. This part also sheds light on the gap between supple and consumption. Import and export figures are also given in this part.

Competitors – In this section, various Caspase 8 Market leading players are studied with respect to their company profile, product portfolio, capacity, price, cost and revenue.

Other analyses – Apart from the aforementioned information, trade and distribution analysis for the Caspase 8Market, contact information of major manufacturers, suppliers and key consumers is also given. Also, SWOT analysis for new projects and feasibility analysis for new investment are included.

Customization of the Report: This report can be customized as per your needs for additional data up to 3 companies or countries or 40 analyst hours.

Note: All the reports that we list have been tracking the impact of COVID-19 on the market. Both upstream and downstream of the entire supply chain has been accounted for while doing this. Also, where possible, we will provide an additional COVID-19 update supplement/report to the report in Q3, please check for with the sales team.

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lupine-publishers-rrhoaj · 4 years ago

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Lupine Publishers|Digitoxin has Specific Properties for Potential use to Treat Cancer and Inflammatory Diseases

Lupine Publishers | Journal of Health Research and Reviews

Abstract

New knowledge about diseases on the molecular level demonstrates that inflammation is a common determinant for seemingly very different disorders. Long standing high levels of pro-inflammatory cytokines is an important factor also for cancer. In fact, the pro-inflammatory cytokines may stimulate normal cells, such as immune cells and fibroblasts, to produce more growth factors and cytokines that the cancer cells take advantage of and a vicious circle occurs. More focus is now on this interaction in cancer research and how to break it. Pancreas cancer is a typical example with a lot of stroma in relation to the cancer cells. Cardiac glycosides, especially in the form of digitoxin, have very interesting properties when it comes to target these mechanisms on the molecular level.

Keywords: Cardiac Glycosides; Digitoxin; Apoptosis; Cancer; Pancreas; Glioblastoma; Cholangiocarcinoma

Abbreviations: NK: Natural Killer, PD-L1: Programmed Death-1-Ligand, CNS: Central Nervous System, EGFR: Epidermal Growth Factor Receptor, NF-κB: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells, CAFs: Cancer-Associated Fibroblasts, TGF-β: Transforming Growth Factor Beta, IL-6: Interleukin-6, TNF-α: Tumor Necrosis Fac

Introduction

The innate immune system plays a pivotal role for eradicating cancer cells in humans. Apoptosis (programmed cell death) in cancer cells triggered by immune cells, such as human NK cells, is a mechanism for the human body to get rid of malignant cells [1]. During studies how to strengthen the innate immune system against cancer we found that cardiac glycosides, digoxin and digitoxin, are potent inducers of apoptosis in different types of cancer cells in doses that are not toxic for humans. Actually, we were the first to show apoptosis in cancer cells by digitalis [2,3]. The last years several new molecular modes of action of the cardiac glycosides of impact for cancer and inflammatory diseases have been shown. Clinical studies of digitalis for cancer are ongoing and in progress, however, almost all use digoxin [4]. Our data indicate that digitoxin has more potent anti-cancer effects, in concentrations that are non-toxic for humans, than digoxin [2-6]. Digitoxin is of interest to use as single agent and in combination with chemotherapy in clinical cancer trials and may also be valuable to suppress harmful inflammatory reactions. Digitoxin may also be combined with radiotherapy and/or new antibodies, such as PD-L1 antibodies, to enhance the anti-cancer effects. This mini-review summarizes some of the most interesting properties of the cardiac glycosides from a clinical point of view.

Background

William Withering made digitalis a common drug to treat cardiac congestion by his book. ”An account of the Foxglove and some of its Medical uses with practical remarks on the dropsy, and other diseases”, published in 1785. Digitalis extract had been used in folk medicine much earlier, but Withering’s observations led to a more rational use. Plant extracts containing cardiac glycosides, for example from Nerium Oleander, have been documented in remedies against cancer as early as in the Middle Ages from different parts of the world [3]. Today digitalis, in the form of the cardiac glycosides digoxin and digitoxin, is used to treat cardiac congestion and some arrhythmias, however, the use is decreasing and digitoxin has been taken off the markets in many countries as it has been replaced by other cardiac drugs. Generally, digoxin is regarded easier to dosage than digitoxin and digoxin has been more common to use than digitoxin. Digoxin has a shorter half-life than digitoxin. The chemical difference is that digoxin has an extra hydroxyl group (-OH) compared to digitoxin; i.e. digoxin is more hydrophilic and is excreted by the kidneys. Digitoxin is mainly metabolized in the liver and excreted by the faeces. Digitoxin is lipophilic and pass the blood-brain barrier and reach the CNS and higher than plasma concentrations in the liver, kidneys, brain and heart [3]. The renal function has a” normal decline” by increasing age, in contrast to liver function, and most patients with cardiac congestion are older, thus, digitoxin may be safer in this patient population [7]. Recently, a debate among cardiologists has started; maybe digitalis has been replaced too early by newer drugs. Studies comparing the newer cardiac drugs to digitalis are lacking [8]. Digitalis has the unique capability to increase the inotropic effect of the cardiac muscle without increasing the oxygen consumption. Interestingly, healthy volunteers taking digitoxin in therapeutic dose for treating cardiac congestion, had reduced diastolic blood pressure and heart rate during overnight sleep, probably because of increased parasympathetic activity or decreased sympathetic activity [9]. Time will show if digitoxin will have a renaissance in cardiology.

Properties of Cardiac Glycosides Pivotal for Cancer and Inflammation

Jens C. Skou made the first discovery of an ion-transporting enzyme, the ubiquitous plasma membrane Na+/K+ ATPase in 1957. The main pharmacological effect of clinical benefit of the cardiac glycosides seemed to be inhibition of the Na+/K+ ATPase on cardiac muscle cells and the subsequent ion changes with increased intracellular calcium ion concentration leading to a positive inotropic effect on the heart. Since we reported apoptosis in cancer cells by cardiac glycosides, it has become obvious that the Na+/ K+ ATPase have two distinct roles; the well known as an ion pump and in addition as a protein-protein signal transducer. Increased intracellular calcium ion concentration is a part of the apoptotic cascade and in addition the Na+/ K+ ATPase signals through several other signaling pathways that regulate apoptosis and proliferation, such as through the pathways of EGFR and other tyrosine kinase receptors [10]. Notably, digitoxin is a strong inhibitor of the transcription factor NF-κB and can abolish the production of proinflammatory cytokines [11]. The tumor micro-environment and stroma directly influences the progression of solid tumors through secretion of growth factors and extracellular matrix depositions. CAFs support angiogenesis and cancer cell invasion and metastasis. TGF-β from cancer cells start differentiation of fibroblasts to CAFs. This mechanism seems to be present for different types of solid tumors, such as glioblastoma, pancreas cancer, prostate cancer and also for several hematological malignancies. Pro-inflammatory cytokines such as IL-6 and TNF-α are often involved in this interplay between the cancer cells and stroma cells as well [12-15]. Cardiac glycosides have the ability to inhibit this process [11,12,16]. The capability of digitoxin to inhibit NF-κB and by that abolish the pro-inflammatory cytokines, may be useful for an array of chronic inflammatory disorders such as ulcerative colitis, Crohn´s disease, systemic sclerosis among other diseases. However, real high levels of the pro-inflammatory cytokines may be acute life threatening. The bird flu virus, H5N1, killed many young healthy adults with intact immune systems. The main cause of death of these individuals were respiratory distress caused by a “cytokine storm”, hyper-production of pro-inflammatory cytokines; the immune system overreacted towards the virus [17,18]. It was great concern during the H5N1 epidemic how to handle the situation as the accessible antiviral drugs were not very effective. It would be worthwhile to evaluate digitoxin in this context if such a situation occurs again and we do not have any other effective drugs.

Digitoxin makes the cancer cells immunogenic, especially in combination with some type of chemotherapy [19,20]. The immunogenic effect of digitoxin as well as the inhibition of IL-6 and similar pro-inflammatory factors may make digitoxin an effective combination with newly developed PD-L1 antibodies [21]. In addition, we and others have shown a radio-sensitizing effect of cardiac glycosides on cancer cells [3]. Naturally, one wonder if all these interesting molecular effects of the cardiac glycosides are clinically relevant. Epidemiological studies may give some indications. We examined a population of more than 9000 patients on digitoxin for cardiac disease and correlated to data in the Norwegian Cancer Registry. This population has serious cardiac disease and eventual anti-cancer effects may be masked behind the high morbidity and mortality due to the cardiac conditions. Still, significant anti-cancer effects were detected for leukemia/lymphoma and urothelial and kidney cancer [22]. Several epidemiological studies on digitalis and cancer have been done, most concerning digoxin, and the results differ considerably. Some studies find anti-cancer effects, others not, some studies indicate an increased risk for cancer in a population on digitalis [23-25].

It has been hypothesized that the anti-cancer effect of digitalis is due to an estrogen effect and that this estrogen effect also could increase the risk for some cancers [26]. However, in our experiments we found estrogen expressing breast cancer cells to be less sensitive for digitoxin compared to receptor negative breast cancer cells [3]. Recent data confirm that mechanisms other than interaction with hormone receptors are the main effect of digitalis on breast cancer cells [27].

Digitoxin has complex dose dependent mechanisms of action; lower concentrations may induce transcription of survival genes whereas higher concentrations can induce cell death by caspase activation and apoptosis and even higher concentrations induce cell death through necrosis due to heavily disrupted ion homeostasis. Digitoxin seems to target several signaling mechanisms of crucial roles for cancer cells simultaneously and that might make it more difficult for the cancer cells to develop resistance [3,10].

Conclusion

Despite the vast number of in vitro studies, epidemiological studies and clinical cancer studies done the last 10+ years, still we do not know if any cardiac glycoside will have a role in oncology. Most of the clinical studies so far are on digoxin and a few other cardiac glycosides, however, digitoxin seems most promising as an eventual anti-cancer drug. Considering the molecular modes of actions and pharmacokinetics of digitoxin; glioblastoma, pancreatic cancer, leukemia/lymphoma, kidney cancer, urothelial carcinoma and cholangiocarcinoma are some of the most interesting types of cancer for digitoxin treatment. Digitoxin can be combined with chemotherapy, immune therapy and radiotherapy in these clinical trials.

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abbkine · 5 years ago

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New Post has been published on Abbkine - Antibodies, proteins, biochemicals, assay kits for life science research

Caspase(1,2,3,4,6,8,9) Assay Kit- Simple and convenient, to boost your apoptosis study

【Tips】If you are studying whether a certain drug can trigger apoptosis which relys on the caspase related pathway, and want to detect the activity of caspase, this article is suitable for you! This article is especially fit for researchers who are working hard to benefit the mankind.

【Background】

Caspases(cysteine-aspartic proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. The cascade reaction caused by caspases is a central part of the apoptotic process, and its activation mainly includes the mitochondria-dependent pathway and the death receptor-mediated signal transduction pathway. The downstream caspases are then activated, leading to apoptosis by cleavage of specific substrates. Inhibition of apoptotic function will lead to tumorigenesis and abnormal immune function. However, hyperfunction of apoptotic function is closely related to the pathogenesis of tissue damage and organ failure.

【Caspase Structure】

【Assay Principle】

Abbkine Caspase Assay Kits are based on different caspases can catalyze specific substrates to generate pNA(p-nitroaniline), resulting in the release of p-nitroaniline (pNA), which can be quantified using a spectrophotometer or a microtiter plate reader at at 405 nm.

Product name Cat# Caspase-1 Assay Kit (Colorimetric) KTA3020 Caspase-2 Assay Kit (Colorimetric) KTA3021 Caspase-3 Assay Kit (Colorimetric) KTA3022 Caspase-4 Assay Kit (Colorimetric) KTA3023 Caspase-6 Assay Kit (Colorimetric) KTA3024 Caspase-8 Assay Kit (Colorimetric) KTA3025 Caspase-9 Assay Kit (Colorimetric) KTA3026

【Assay Procedure】

Add samples, background control and standard

Add Reaction Buffer and substrate, incubate

Read samples at 405 nm

Simple three steps, a big step in scientific research!

About Abbkine Scientific Co., Ltd.

Abbkine serves global scientists in the field of proteomics and cytology and is committed to the innovation and development of various scientific reagents related to proteomics and cytology, expecting to accelerate the pace of life science research and drug discovery. Proteomics products cover the preparation of samples (protein extraction, purification, coupling), protein quantification, antibodies and kits for protein detection. Cytology products involve cytokines (cell culture), cell status detection, cell staining, organelle extraction, cell metabolism and cytopathology reagents (kits). Abbkine relies on the product portfolio and unique marketing support as the main market strategy and product innovation mode, with ultimate aim to facilitate your research career.

#Apoptosis #Caspase Assay Kit

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paullassiterca · 6 years ago

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Replace Dangerous Oils With Healthy Fats

30 Tips in 30 Days Designed to Help You Take Control of Your Health

This article is included in Dr. Mercola’s All-Time Top 30 Health Tips series. Every day during the month of January, a new tip will be added that will help you take control of your health.

Dietary fats are a crucial component of a healthy diet, but the devil’s in the details, and the type of fats you choose can make a world of difference. While the notion that saturated fats cause heart disease is a fallacy, some fats do cause cardiovascular problems and need to be avoided.

Replacing dangerous oils with healthy fats is one simple way to boost your health and reduce your risk of chronic disease. Here, I’ll review some of the key points to remember when adding more fat into your diet.

Trans Fat — A Hidden Culprit in Heart Disease for Decades

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Before 1900, American housewives used lard and butter for cooking. It wasn’t until 1911 that our diets experienced a dramatic change with the introduction of trans fat in the form of Crisco, the first hydrogenated vegetable oil product to hit the market.

Hydrogenated vegetable oils and margarine quickly became the backbone of the food industry. In my new book “Superfuel: Ketogenic Keys to Unlock the Secrets of Good Fats, Bad Fats, and Great Health ,” cowritten with James DiNicolantonio, Pharm.D, we take a deep dive into this topic. In fact, our book reveals how the consumption of soybean oil has increased over a thousand percent from 1909 to 1999.

Trans fats became a staple dietary fat with the introduction of processed foods, and could be found in everything from cookies and crackers to french fries and frozen food. Unfortunately, it would take more than a century for the truth about trans fat to be fully recognized.

The U.S. Food and Drug Administration (FDA) didn’t remove partially hydrogenated oils from the generally recognized as safe (GRAS) list until 2015,1 based on evidence suggesting their removal could prevent thousands of heart attacks and deaths each year.

In reality, research by Fred Kummerow, dating back to 1957, showed that trans fat interferes with the basic functioning of cellular membranes. Even small amounts of manufactured trans fat have been shown to have adverse effects on your heart, insulin sensitivity and neurological system.

Processed Vegetable Oils Do More Harm Than Good

In response to research and public opinion, many restaurants have since turned from partially hydrogenated oils to 100 percent vegetable oil. However, while these oils do not have trans fats, they’re just as bad, if not worse. There are three significant reasons for this:

When heated, vegetable oils degrade to extremely toxic oxidation products, including cyclic aldehydes,2 which have been linked to neurodegenerative diseases and certain types of cancer. In her book, Teicholz cites research showing that aldehydes cause toxic shock in animals through gastric damage

Vegetable oils are a concentrated source of omega-6 linoleic acid, which has led to a severe imbalance between the omega-6 to omega-3 ratio in most people’s diets

Many of the vegetable oils produced today — especially corn and soy — are products of genetic engineering (GE) and a significant source of glyphosate exposure, and glyphosate has also been linked to gut damage and other health problems

In summary, processed vegetable oils (polyunsaturated fat) harm health by:

Creating high amounts of oxidation products when used in cooking (as they are very susceptible to heat), including aldehydes, which are what cause oxidized low-density lipoprotein (LDL) associated with heart disease. Aldehydes also crosslink tau protein and create neurofibrillary tangles, thereby contributing to the development of neurodegenerative diseases.

Damaging the endothelium (the cells lining your blood vessels) and causing an increase in penetration of LDL and very low-density lipoprotein (VLDL) particles into the subendothelium. In other words, these oils get integrated in your cell and mitochondrial membranes, and once these membranes are impaired, it sets the stage for all sorts of health problems.

Damaging your mitochondria and DNA by making your cell membranes more permeable, allowing things to enter that shouldn’t.

Making the cell membrane less fluid, which impacts hormone transporters in the cell membrane and slows your metabolic rate.

Inhibiting cardiolipin, an important component of the inner membrane of your mitochondria that needs to be saturated in DHA in order for it to function properly.

Cardiolipin can be likened to a cellular alarm system that triggers apoptosis (cell death) by signaling caspase-3 when something goes wrong with the cell. If the cardiolipin is not saturated with DHA, it cannot signal caspase-3, and hence apoptosis does not occur. As a result, dysfunctional cells are allowed to continue to grow, which can turn into a cancerous cell.

Inhibiting the removal of senescent cells, i.e., aged, damaged or crippled cells that have lost the ability to reproduce and produce inflammatory cytokines that rapidly accelerate disease and aging.

Stripping your liver of glutathione (which produces antioxidant enzymes), thereby lowering your antioxidant defenses.3

Inhibiting delta-6 desaturase (delta-6), an enzyme involved in the conversion of short-chained omega-3s to longer chained omega-3s in your liver.4

Exposing you to toxic 4-hydroxynonenal (4HNE), which forms during the processing of most vegetable oils, even if the oil is obtained from organic crops. 4HNE is highly toxic, especially to your gut bacteria, and consumption of 4HNE has been correlated with having an obesogenic balance of gut flora. It also causes DNA damage and instigates free radical cascades that damage your mitochondrial membranes.5

Exposing you to glyphosate residues, as most vegetable oils are made with genetically engineered crops. Glyphosate has been shown to disrupt the tight junctions in your gut and increase penetration of foreign invaders, especially heated proteins, which can cause allergies.

Address Your Omega-6 to Omega-3 Ratio to Protect Your Health

Marine-based omega-3 is one of the most important fats in the human diet, as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are actually key structural elements of cells, including your brain cells, and not just simple fuel. If you don’t have enough DHA and EPA, your body’s ability to repair and maintain healthy cell structures is seriously impaired.

Unfortunately, in the past 100 years, our omega-6 intake has nearly tripled while our intake of omega-3 has decreased 10fold, and this imbalance has also likely played a significant role in our skyrocketing disease rates. Eating too much damaged omega-6 fat — found in abundance in processed vegetable oils — and too little animal-based omega-3 sets the stage for diabetes, cardiovascular disease, rheumatoid arthritis, cancer, depression and Alzheimer’s, just to name a few.

Now, omega-6 fat in and of itself is not the problem. The problem is that most people get far too much of it, and insufficient amounts of omega-3, and that most of the omega-6 people eat has been damaged and oxidized through processing. Evidence implicating excessive consumption of omega-6-rich vegetable oils as a direct cause of heart disease include but is not limited to:6

The amount of linoleic acid in adipose tissue and platelets is positively associated with coronary artery disease, and studies7 measuring changes in linoleic acid concentrations in adipose tissue in Americans show concentrations increased from 9.1 percent in 1959 to 21.5 percent in 2008. This increase also paralleled increases in the prevalence of obesity, diabetes and asthma.

Conversely, the long-chained omega-3s docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been shown to protect against coronary artery disease, which is why maintaining a healthy balance between omega-3 and omega-6 is so important.

Patients with atherosclerosis have higher amounts of linoleic acid oxidation products in their plasma, low-density lipoprotein (LDL) and atherosclerotic plaques.

Oxidation of linoleic acid begins before any clinical signs of atherosclerosis become apparent.

When the endothelium (the interior lining of your blood vessels) is exposed to linoleic acid, LDL transfer across the endothelium is increased and this is an essential step in the atherosclerotic process.

Low linoleic acid diets reduce LDL oxidation.

A meta-analysis of randomized controlled trials in humans showed that when saturated fat and trans fat are replaced with omega-6 PUFAs, all-cause mortality, ischemic heart disease mortality and cardiovascular mortality increase.

Oxidation products of linoleic acid are found in infarcted tissue.

The linoleic acid metabolite 9-HODE is a strong promoter of inflammation, and may be both a marker for and inducer of atherosclerosis.

How to Balance Your Omega Fat Ratios

Ideally, you want to maintain a ratio somewhere in the range of (4-2)-to-1 of omega-6 and omega-3 fats. This, however, is nearly impossible if you’re regularly eating processed foods or restaurant fare, as these are loaded with omega-6 from industrial vegetable oils like corn oil and canola oil.

While you do need omega-6, it should be in its unprocessed form, not industrial vegetable oils. Good sources are whole, raw plant seeds and tree nuts. In summary, to correct your omega-6 to omega-3 ratio, you typically need to do two things:

1. Significantly decrease intake of damaged omega-6 by avoiding processed foods and foods cooked in vegetable oil at high temperatures. A number of studies8,9 have found that people who regularly eat deep-fried foods have a significantly increased risk of stroke and death.

Common sources of harmful omega-6 to avoid include corn oil, canola oil, soy oil, hydrogenated or partially hydrogenated fats, margarine and shortening.

2. Increase your intake of marine-based omega-3 fats. Ideal sources include small fatty fish such as sardines, anchovies and herring, along with wild-caught Alaskan salmon, or a supplement such as krill oil.

Healthiest Fats for Cooking

Getting back to cooking oils, if vegetable oils are “out,” what should you use to cook with? Healthy alternatives include:

• Coconut oil — This is what I believe is the best cooking oil. It has a number of valuable health benefits, including a positive effect on your heart and antimicrobial properties. It’s also a great source of energy, thanks to its medium-chain fatty acids (MCFAs). When consumed, the MCFAs are digested and converted by your liver into energy that you can immediately use. Coconut oil also helps stimulate your metabolism to encourage a healthy weight profile.

• Grass fed butter — Raw, organic butter made from healthy grass fed cows’ milk contains many valuable nutrients, including vitamins A, D, E and K2. Furthermore, it contains various minerals and antioxidants that support good health.

• Organic ghee, which has been used for cooking for thousands of years, is another good choice.

• Olive oil — This oil contains healthy fatty acids that can help lower your risk of heart disease. While the standard recommendation has been to avoid using olive oil for cooking and to only use it cold, recent research10 in which 10 popular cooking oils were compared, contradicts this advice, showing extra-virgin olive oil actually scored best for both oxidative stability and lack of harmful compounds produced when heated.

A word of caution is warranted, however. Fake olive oil abounds, so it’s important to take the time to investigate your sources. Tests reveal anywhere from 60 to 90 percent of the olive oils sold in American grocery stores and restaurants are adulterated with cheap vegetable oils or nonhuman-grade olive oils, which are harmful to health in a number of ways.11

For tips on how to assess the quality of your olive oil, see the short video below. For more information, see “Is Your Olive Oil Fake?” where I cover this topic in-depth.

youtube

Peanut oil and sesame oil are two other healthy options. While both are high in omega-6, peanut oil is high in antioxidants, and sesame oil has been shown to benefit diabetics. The caveat with these two oils is that you need to consume them unheated and in moderation, so as not to throw off your omega-6 to omega-3 ratio.

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Black Seed Oil — The Forgotten Gem

Black seed (Nigella Sativa) oil is another exceptional fat with a long history of use in traditional systems of medicine, including Ayurveda and Siddha. The most abundant active plant chemical in black seed is thymoquinone; other bioactive compounds include α-hederin, alkaloids, flavonoids, antioxidants and fatty acids.

As for its antioxidant activity, black cumin seed has been found to be far more potent than vitamin C.12 In modern times, researchers have confirmed Nigella Sativa may be helpful for:

Type 2 diabetes — In one study, Nigella sativa improved glucose tolerance as efficiently as metformin.13 It’s also been shown to improve the performance of antidiabetic medication14

Reducing asthma symptoms — In one study,15 thymoquinone was found to be instrumental, by reducing two inflammatory mediators of asthma and other inflammatory processes.

Another study16 found black cumin seed also acts as a relaxant, and displays both anticholinergic (reducing spasms in smooth muscle) and antihistaminic (blocking allergic reactions) effects. Here, thymoquinone was found to be superiorto the asthma drug fluticasone (a synthetic glucocorticoid)

Enhancing memory and reducing stress — The results showed black cumin seed inhibited stress-induced biochemical changes in a dose-dependent manner. Memory and cognition was also dose-dependent17

Reducing damage caused by cadmium poisoning18 — May also serve as prophylactic against chemical warfare agents

Protecting against and attenuating aflatoxicosis19

Alleviating symptoms of allergic rhinitis20

Candidiasis21

Rheumatoid arthritis22

Cancer23,24,25

Black seed oil has at least 20 different pharmacological actions, which helps explain how it can be useful for so many different and varying ailments, including:26

Antidiabetic

Anti-cancer

Immunomodulatory

Analgesic (pain relief)

Antimicrobial

Anti-inflammatory

Spasmolytic

Bronchodilator27

Hepatoprotective

Renal protective

Gastroprotective

Antioxidant

How to Use Black Seed Oil

Black seed oil is a highly undervalued and oft-forgotten kitchen staple. When used in cooking, it imparts a warm, slightly bitter flavor that tastes something like a blend of thyme, oregano and nutmeg.

A mixture of black seed oil, honey and garlic also makes for a powerful tonic that can help soothe coughs and boost immunity, especially during cold and flu season or if you feel like you’re coming down with an infection.28

Like all seeds, black seed oil is high in polyunsaturated fats. So, when taken in excess, it could make your mitochondrial membranes more susceptible to oxidation.

For this reason, I suggest limiting your daily intake to 1 to 2 tablespoons or less. A simple way to get a small amount of black seed oil into your diet on a regular basis is to use it in your homemade dressing. Here are a few suggestions:

Mix apple cider vinegar, black seed oil, fresh lemon juice, cilantro and tahini. Experiment with the ratios to enhance the flavor you enjoy the most

A simple and yummy dressing that goes particularly well with broccoli, asparagus or salad greens includes: 1 tablespoon apple cider vinegar, 1 tablespoon lemon juice, one-half teaspoon minced garlic, a dash of ground black pepper and a few fresh basil leaves, chopped

Alternatively, you can use apple cider vinegar and/or black seed oil as substitutes for other oils and vinegars in whatever dressing recipe you’re already using. Keep in mind that the black seed oil does have a spicy kick to it, so substituting the full amount may make it too spicy. Start by adding just a small amount, and experiment to find the ratio of vinegar, olive oil and black seed oil you enjoy

Optimize Your Health by Selecting the Right Fats

The list below, obtained from Dr. Cate Shanahan, author of “Deep Nutrition: Why Your Genes Need Traditional Food,” summarizes some of the best and worst fats found in our modern diet. Replacing the bad fats in your diet with ones from the “good” list is a simple way to safeguard your health without making any radical changes.

To learn more about the ins and outs of dietary fats, pick up a copy of my latest book, “Superfuel: Ketogenic Keys to Unlock the Secrets of Good Fats, Bad Fats, and Great Health,” cowritten with James DiNicolantonio, Pharm.D., which gives more in-depth specifics on how to discriminate between healthy and harmful dietary fats.

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Tip #6Avoid Becoming a Cancer Statistic

from Articles http://articles.mercola.com/sites/articles/archive/2019/01/07/replace-dangerous-oils-with-healthy-fats.aspx source https://niapurenaturecom.tumblr.com/post/181796702211

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acquiremarketresearch · 5 years ago

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Global Caspase 8 - How the Market Will Witness Substantial Growth in the Upcoming years?

Global Caspase 8 – How the Market Will Witness Substantial Growth in the Upcoming years?

“Caspase 8 Market 2019” describes an in-depth evaluation and professional study on the present and future state of the Caspase 8 market across the globe, including valuable facts and figures. Caspase 8 marketprovides information regarding the emerging opportunities in the Caspase 8 market & the market drivers, trends & upcoming technologies that will boost these growth trends. The Report…

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snehalaxel · 3 years ago

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Caspase Activity Assay Kit Market Size & Share 2020 | Growth With Top Players By 2025

Caspase Activity Assay Kit Market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Caspase Activity Assay Kit Market is growing at a High CAGR during the forecast period 2021-2027. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market”.

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Covid-19 episode to adversely affect the marketplace

The covid-19 pandemic has impacted the marketplace likewise as countless interrupted sectors around the world. silicone rubber is majorly made use of in the vehicle sector for the manufacturing of tires as well as several elements. during this pandemic, numerous nations consisting of china, india, germany, italy, brazil, as well as canada stated complete lockdown. this more caused the closure of production centers, and also resources transportation. this epidemic has drastically influenced the supply chain of various making systems. since, both resources supply and also finished products circulation is majorly influenced, creating a massive decrease in income. china is a significant consumer of materials as well as an epicenter of coronavirus, therefore, hindering the advancement of the market. restrictions over export and import of items such as tires, basic, and industrial items functions as an aspect for the decline of the marketplace.

By Market Players: AAT Bioquest, Inc. Abcam plc. AnaSpec, Inc. Biotium BioVision，Inc. Enzo Biochem Inc. Promocell, Inc. Thermo Fisher Scientific Abnova Corporation Sigma-Aldrich By Type Caspase 1 Activity Assay Kit Caspase 2 Activity Assay Kit Caspase 3 Activity Assay Kit Caspase 4 Activity Assay Kit Caspase 6 Activity Assay Kit Caspase 8 Activity Assay Kit Caspase 9 Activity Assay Kit Caspase 3/7 Activity Assay Kit By Application Research Laboratory Hospital Others

A detailed outline of the Global Caspase Activity Assay Kit Market includes a comprehensive analysis of different verticals of businesses. North America, Latin America, Asia-Pacific, Africa, and Europe have been considered for the studies on the basis of several terminologies.

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Global Caspase Activity Assay Kit Market Overview

Economic Impact on Industry

Market Competition by Manufacturers

Production, Revenue (Value) by Region

Production, Revenue (Value), Price Trend by Type

Market Analysis by Application

Cost Analysis

Industrial Chain, Sourcing Strategy and Downstream Buyers

Marketing Strategy Analysis, Distributors/Traders

Market Effect Factors Analysis

Global Caspase Activity Assay Kit Market Forecast

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Axel Reports has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the world’s most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

Contact: Axel Reports Akansha G (Knowledge Partner) Office No- B 201 Pune, Maharashtra 411060 Phone: US +18488639402 Email: [email protected]/ Web: https://axelreports.com/

" "

Get the PDF Sample Copy (Including FULL TOC, Graphs and Tables) of this report @:https://axelreports.com/request-sample/77843

Covid-19 episode to adversely affect the marketplace

Make an Enquiry for purchasing this Report :https://axelreports.com/enquiry-before-buying/77843

Reasons for buying this report:

It offers an analysis of changing competitive scenario.

For making informed decisions in the businesses, it offers analytical data with strategic planning methodologies.

It offers seven-year assessment of Global Caspase Activity Assay Kit

It helps in understanding the major key product segments.

Researchers throw light on the dynamics of the market such as drivers, restraints, trends, and opportunities.

It offers regional analysis of Global Caspase Activity Assay Kit Market along with business profiles of several stakeholders.

It offers massive data about trending factors that will influence the progress of the Global Caspase Activity Assay Kit

Table of Contents:

Global Caspase Activity Assay Kit Market Overview

Economic Impact on Industry

Market Competition by Manufacturers

Production, Revenue (Value) by Region

Production, Revenue (Value), Price Trend by Type

Market Analysis by Application

Cost Analysis

Industrial Chain, Sourcing Strategy and Downstream Buyers

Marketing Strategy Analysis, Distributors/Traders

Market Effect Factors Analysis

Global Caspase Activity Assay Kit Market Forecast

ABOUT US:

Contact: Axel Reports Akansha G (Knowledge Partner) Office No- B 201 Pune, Maharashtra 411060 Phone: US +18488639402 Email: [email protected]/ Web: https://axelreports.com/

#Caspase Activity Assay Kit Caspase Activity Assay Kit Market Application Caspase Activity Assay Kit Market Drivers Caspase Activity Assay K

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abrreports-blog · 5 years ago

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Caspase 3 Market Key Trends, Drivers, Growth Opportunities, and 2025 Industry Chain Structure Analysis

The research study Caspase 3 market 2020 launched by ABRReports.com provides the detailed analysis of current market status, investment plans, production and consumption, price trends, leading key companies, growth drivers and future prospect. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025

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The segmentation of Caspase 3 study as mentioned below:

By Market Players:

Aptose Biosciences Inc, BeyondSpring Pharmaceuticals Inc, Conatus Pharmaceuticals Inc, New World Laboratories Inc, Pharmedartis GmbH, Sanofi, Shire Plc

By Application

Liver Cirrhosis, Liver Failure, Pulmonary Fibrosis, Solid Tumor, Others1G3-Cu, BaxM-159, Emricasan, IDN-7314, Others

The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data from 2014 to 2019 and forecast data from 2020 to 2025.

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The key objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

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Key pointers of the Table of Contents:

Chapter 1 Industry Overview

Chapter 2 Major Segmentation (Classification, Application and etc.) Analysis

Chapter 3 Production Market Analysis

Chapter 4 Sales Market Analysis

Chapter 5 Consumption Market Analysis

Chapter 6 Production, Sales and Consumption Market Comparison Analysis

Chapter 7 Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 8 Marketing Channel Analysis

Chapter 9 Industry Chain Analysis

Chapter 10 Global and Regional Market Forecast

Chapter 11 Major Manufacturers Analysis

Chapter 12 New Project Investment Feasibility Analysis

Chapter 13 Conclusions

Continued…

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#Caspase 3 market #Caspase 3 market size #Caspase 3 market share #Caspase 3 market 2020 #Caspase 3 market forecast #global Caspase 3 market trends

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soumyafwr · 11 months ago

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https://twikkers.nl/blogs/174365/Caspase-8-Market-Overview-Competitive-Analysis-and-Forecast-2031

Caspase 8 Market Overview, Competitive Analysis and Forecast 2031

#Caspase 8 Market #Caspase 8 Market Scope #Caspase 8 Market Report #Caspase 8 Market Research

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edwardebreen15 · 3 years ago

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Apoptosis Assay Market Share, Trends, Growth, Sales, Demand, Revenue, Size, Forecast and COVID-19 Impacts to 2021-2026