#CODATA

[sciencedayforpeaceanddev]

Beyond the Microscope: Cryo-EM’s Impact on Accelerating Drug Discovery.

A collaboration between the U.S. National Committees on: Crystallography, Chemistry, CODATA & the Board on Chemical Sciences and Technology.

As part of Advancing Drug Discovery: A Webinar Series of the National Academies of Sciences, Engineering and Medicine, a session on Beyond the Microscope: Cryo-EM’s Impact on Accelerating Drug Discovery will be held on Thursday, November 16th, 2023 at noon (EDT). The 60-minute session will consist a presentation from Sandra Gabelli, Head of Structural biology at Merck & co and formally Executive Director of Protein and Structural Chemistry.

Over the past decade, single particle cryo electron microscopy (cryoEM) has transitioned from a niche technique to a powerful tool for structural biology. This is due, in part, to technological breakthroughs which have made it relatively routine to achieve near molecule formulations for protein targets of pharmacological interest in complex with drug candidates. The pharmaceutical industry has historically relied heavily on X-ray crystallography to enable structure-based drug design (SBDD); however, today cryoEM is playing an ever-increasing role in that process, especially for challenging samples like large multimeric complexes, proteins that are flexible, or proteins that are difficult to express or purify. Dr. Gabelli will describe the strategy and present examples were cryoEM has impacted the pipeline at Merck by enabling biology, guiding SBDD, driving protein engineering of biologics and impacting small molecule formulations with micro ED. Dr. Gabelli will also explore the potential offered by upcoming technological advancements of the technique.Register

[kurano]

こうした標準模型をはじめとする理論モデルは、自然界の物理法則を反映した数式を内包するように構成されている。この数式に不可欠なのが、電子の質量や光速などの値である物理定数だ。物理定数は、一度確認されたらその数値が不変であるわけではなく、標準模型の予測とさまざまな精密実験の結果ができるだけ一致するよう、科学技術データ委員会(CODATA)によって数年ごとに調整されている。この時、自然界の物理法則として、標準模型は厳密に正しいという前提のもとに調整が行われる。

不変だと思ってた。

[pontaoski]

that dot thing is a thing in some languages, it's usually called unified function call syntax (UFCS) in languages like D and (iirc) Nim?

also defining objects in this way (by their "consumer" functions) is codata (as opposed to data, which is defining objects by their "construction")

codata is nifty and lets you have a lot of things that you couldn't have with data in a sound manner unless you change the lens to codata

OOP is like. Every variable comes with some pre-Curried functions. Or every variable is identified with the evaluation operator on functions of the appropriate type.

Right, like...

If I make a class

class thingy { int x int y int get_x() {return x} int get_y() {return y} int prod() {return x*y}

}

Or whatever, I'm basically building a compound type, like

data Thingy = (Int, Int)

in this case, but saying that I want to identify a variable x of this type with the operator

\f -> f(x)

of type

((Int, Int) -> a) -> a

Except like, only for the functions I specified as methods in the original class definition. Which seems so dumb to me.

Like, identifying objects of type b with objects of type (b -> a) -> a is very natural (double dual and all that) and I can see why you'd want to do it. That could almost be an argument for OOP. Except it's like. Limited to the functions you specify in the class definition. Which seems so dumb!

But I don't know. I'm not a programmer.

[hackernewsrobot]

Codata in action, or how to connect FP and OOP

https://www.javiercasas.com/articles/codata-in-action/ Comments

[hateboat]

the medium sized rat who is banned from making any rules. here we have @joebob6448 's codata again who ive thembofied. i didnt mean for this but Oh Well!

[universo-genial]

A constante de gravitação universal, também chamada por constante newtoniana de gravitação, constante gravitacional universal, constante de Newton, grande G ou simplesmente constante gravitacional (símbolo: G), é uma constante da física universal da lei de Newton. . Segundo a Lei da atração universal, a força de atração entre dois corpos é proporcional ao produto de suas massas e inversamente proporcional ao quadrado da distância que as separa: F= G (m1.m2 / r²) . Trata-se de uma das constantes físicas cujo valor é menos preciso. A massa do Sol, como é calculada a partir desta constante é, portanto, também calculada com alguma incerteza. A primeira medição do seu valor foi efetuada por Henry Cavendish, na sua obra Philosophical Translations, de 1798. . Atualmente o CODATA (comité interdisciplinar do Conselho Internacional de Ciência,2008) recomenda para a constante de gravitação universal o valor de: G = 6,67428(67) x 10-11 m3 kg-1 s-2 . A constante de gravitação universal G não deve ser confundida com g (em minúscula), que é o símbolo normalmente associado à variável que representa a intensidade da aceleração da gravidade terrestre junto à superfície do planeta, ou outro astro, quando explicitamente especificado. Em termos de G, g expressa-se como: g=G.m1.m2/r² onde m e r representam nesse caso a massa e o raio do astro esférico. Para a Terra a aceleração da gravidade vale por volta de g = 9,81 m/s2. ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ 🚀Marquem seus amigos, e sigam o @universo.genial ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ #universogenial #ciencia #astronomia #fisica #quimica #biologia #personalidades #curiosidades #universo #cosmos #vida #astrofisica #genial #astronauta #divulgação #cosmologia #vocesabia #livro #facebook #instagram #twitter #tumbl #science #astronomy #sorteios #correnteastronomica #live #astrofilia #sigame ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ Créditos @universo.genial ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ https://www.instagram.com/p/B61LbfLjyXp/?igshid=pw55xa3a9axl

[latestsciencedailynews-blog]

[hiredrita]

Pcalc ios scientific

Pcalc ios scientific mac os#

Pcalc ios scientific upgrade#

Support for macOS 10.15 Catalina, including Dark Mode.Support for the Touch Bar on the MacBook Pro.Handoff of in-progress calculations between PCalc on iOS, macOS, and watchOS.Smart searching of conversions, functions, and constants.A simulated paper tape to keep track of your calculations with a “ticker tape” mode under the main display.Hexadecimal, octal and binary modes, complete with a variety of bitwise operators.Editable user conversions, functions, and constants which are synced automatically across multiple devices.An RPN mode with one button access to the stack, and optional multiple-line display.Calculator themes – pick your look, all the way from minimalist to striking.A powerful Notification Center widget, for quick access to PCalc.Includes all the layouts from the iPhone and iPad, as well as Mac-specific ones. Switchable button layouts – choose from many different horizontal and vertical layouts to suit your needs.

Pcalc ios scientific mac os#

The updated app also includes a new nighttime theme on iOS 7. PCalc is a high-powered scientific calculator that goes beyond the features found in the built-in Mac OS scientific calculator. Pcalc 4 2 – Full Featured Scientific Calculator Online Popular scientific calculator app PCalc was updated today with new features including 64-bit support for the iPhone 5s and new iPads. If you wrote a review already, updating it for 4.0.2 would be great too. Hope you like it! Reviews are appreciated, as they are a good way to encourage people to buy.

Pcalc ios scientific upgrade#

As with PCalc 4.0, this is a free upgrade for existing Mac App Store users, and for anybody who purchased PCalc 3 via Kagi since the 1st of April 2013.

Improved the UI for using multiple memories in the widget. Improved accuracy of stored numbers when PCalc isn't running, and for copying and pasting.

Updated all scientific constants to the latest CODATA 2018 values, and now include the full list.

User functions and conversions can now access the RPN stack, use bitwise operators, and get and set values on the clipboard. Smart searching for conversions, constants, and functions - try “£ to $” in the search field, for example.

Updated the core calculator code to match PCalc 4 on OS X.

engineering and scientific notation, as well as support for hexadecimal, octal. PCalc 4.2 (Mac OS X) Categories: Software » Mac PCalc is a full-featured, scriptable scientific calculator with support for hexadecimal, octal, and binary calculations, as well as an RPN mode, programmable functions, and an extensive set of unit conversions. The PCalc calculator app for iOS has been updated with 64-bit support. Zcommander total management for files & folders 3 4.

[sciencedayforpeaceanddev]

2023 Vocabulary Symposium: FAIR Vocabularies For All.

Following on from the success of the 2022 Vocabulary Symposium, the ARDC invites you to the 2023 Vocabulary Symposium on 14 and 15 November 2023.

This is a 2-day hybrid event bringing together people from domains across disciplines spanning research, government and industry, including those from the ARDC Thematic Research Data Commons. The aim is to communicate and promote approaches to using, developing, publishing and maintaining vocabularies. The event will cover Australian and international initiatives that demonstrate the impact and value of FAIR vocabularies for maximising the reuse value of data within and across domains.

The program for the Symposium is out now. The Symposium will feature keynote presentations from:

Arofan Gregory, a standards expert at CODATA, who will present on “Controlled Vocabularies in a Changing Metadata Landscape”.

Jen Drysdale, a cultural heritage informatics and analytics specialist at the National Film and Sound Archive of Australia, who will discuss “The Role of Vocabularies in Cultural Heritage and the Impact of New Strategic Drivers”.

Register to participate!

[csdataabase]

Codata Customer Service

If you are looking for codata customer service, simply check out our links below : 1. Codata | Decision support tools for retail and commercial real … https://www.codata-retail.com/ Four services to meet the needs of commercial real estate data. Codata Explorer. The online service. Codata Explorer. Codata Key Plans. The detailed maps. 2. Home – CODATA, The Committee on Data for Science and…

[rh35211]

Permittivity of free space - Energy Education

Vacuum permittivity, commonly denoted ε0 (pronounced as "epsilon nought" or "epsilon zero") is the value of the absolute dielectric permittivity of classical vacuum. Alternatively it may be referred to as the permittivity of free space, the electric constant, or the distributed capacitance of the vacuum. It is an ideal (baseline) physical constant. Its CODATA value is:

ε0 = 8.8541878128(13)×10−12 F⋅m−1 (farads per meter), with a relative uncertainty of 1.5×10−10.[1]

[gratuitescu]

Cablu audio jack stereo 3.5mm 2 x jack 6.3mm mono tata sistem sunet

Cablu audio jack stereo 3.5mm 2 x jack 6.3mm mono tata sistem sunet

Cablu audio jack stereo 3.5mm 2 x jack 6.3mm mono tata sistem sunet Cateva caraceristici de baza: – Conexiune prin cablu perfecta pentru tastaturi, sisteme de home cinema, sintetizatoare pentru desktop si tablete – Conexiune compacta, codata color, pentru birourile de mixat DJ – Conectare fiabila si ecranata pentru monitoarele de studio active si difuzoarele computerului – Cabluri durabile pentru…

[universo-genial]

A constante de gravitação universal, também chamada por constante newtoniana de gravitação, constante gravitacional universal, constante de Newton, grande G ou simplesmente constante gravitacional (símbolo: G), é uma constante da física universal da lei de Newton. . Segundo a Lei da atração universal, a força de atração entre dois corpos é proporcional ao produto de suas massas e inversamente proporcional ao quadrado da distância que as separa: F= G (m1.m2 / r²) . Trata-se de uma das constantes físicas cujo valor é menos preciso. A massa do Sol, como é calculada a partir desta constante é, portanto, também calculada com alguma incerteza. A primeira medição do seu valor foi efetuada por Henry Cavendish, na sua obra Philosophical Translations, de 1798. . Atualmente o CODATA (comité interdisciplinar do Conselho Internacional de Ciência,2008) recomenda para a constante de gravitação universal o valor de: G = 6,67428(67) x 10-11 m3 kg-1 s-2 . A constante de gravitação universal G não deve ser confundida com g (em minúscula), que é o símbolo normalmente associado à variável que representa a intensidade da aceleração da gravidade terrestre junto à superfície do planeta, ou outro astro, quando explicitamente especificado. Em termos de G, g expressa-se como: g=Gm/r² onde m e r representam nesse caso a massa e o raio do astro esférico. Para a Terra a aceleração da gravidade vale por volta de g = 9,81 m/s2. ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ 🚀Marquem seus amigos, e sigam o @universo.genial ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ #universogenial #ciencia #astronomia #fisica #quimica #biologia #personalidades #curiosidades #universo #cosmos #vida #astrofisica #genial #astronauta #nasa #cosmologis #vocesabia #leia #livro #facebook #instagram #twitter #tumblr #science #astronomy #sorteios #correnteastronomica #live #followme #sigame ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ Se você é o proprietário desta arte ou sabe quem é, me avise para que eu possa creditar corretamente. Imagem editada por @universo.genial ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ https://www.instagram.com/p/B2FRmG3jgj2/?igshid=1o76kbs2ttw0h

[ssvauto]

Antifurt Roti Oe Volkswagen Golf 7 2012→ 000071597 ❕❕❕PRET SPECIAL: 280 LEI❕❕❕ ▪️Dupa ce ai petrecut timp pretios pentru a alege rotile potrivite, dupa ce ai investit in spalarea si lustruirea lor, ultimul lucru pe care ti-l doreste este sa ramai fare ele... Volkswagen Accesorii Originale iti ofera acest kit complet de prezoane antifurt, prefect adaptate jantelor originale Volkswagen. Prezoanele antifurt se instaleaza inlocuind unul din prezoanele standard cu care se livreaza masina. Piesele ce compun acest kit sunt realizate din materilale andurante, rezistente la coroziune. ▪️Continut: 1 x Set prezoane antifurt originale Volkswagen, dimensiunea M14 x 1.5 x 27mm, compus din: 4 x prezoane antifurt, 1 x cheie codata, 4 x capace prezoane antifurt negre, 1 x extractor capace si 1 x instructiuni de utilizare; Ambalaj cutie de transport si depozitare realizata din material plastic rezistent. Masini compatibile: ▪️Volkswagen Beetle 2011→ ▪️Volkswagen Caddy 4 2015→ ▪️Volkswagen Eos 2006-2015 ▪️Volkswagen Golf 6 Plus 2009-2014 ▪️Volkswagen Golf 7 2012→ ▪️Volkswagen Jetta 4 2010→ ▪️Volkswagen Passat B7 2010-2015 ▪️Volkswagen Passat B8 2014→ ▪️Volkswagen Passat CC 2008-2012 ▪️Volkswagen Passat CC 2012-2016 ▪️Volkswagen Polo 6R 2010→ ▪️Volkswagen Scirocco 2008-2017 ▪️Volkswagen Tiguan 1 2007-2016 ▪️Volkswagen Tiguan 2 2016→ ▪️Volkswagen Touran 1 2007-2010 ▪️Volkswagen Touran 2 2010-2015 ▪️Volkswagen Touran 2 2015→ Caracteristici: ▪️Produsul este nou Original Volkswagen ▪️M14 x 1.5 x 27mm ▪️Observatii: Prezoanele antifurt originale Volkswagen sunt compatibile doar cu jantele din aliaj usor sau otel originale Volkswagen. Cod: 000071597 Producator: Volkswagen https://www.instagram.com/p/B7bBP7Nnt1Z/?igshid=pk6n4owsp54w

[spaceexp]

CERN know-how helps weigh the proton

CERN - European Organization for Nuclear Research logo. 2 Aug 2017 A team in Heidelberg, Germany has made the most precise measurement to date of the mass of a single proton, the particle that – together with the neutron and the electron – makes up all the ordinary matter in the universe, and therefore also us. They found that the proton is about 30 billionths of a percent lighter than previously thought. The result improves by a factor of three on the precision of the accepted value of the Committee on Data for Science and Technology (CODATA) – which regularly collects and publishes the recommended values of fundamental physical constants – and it also disagrees with its central value at a level of 3.3 standard deviations, which means that the new value is significantly different from the previous result. Proton mass is a fundamental parameter in atomic and particle physics, influencing atomic spectra and allowing tests of ultra-precise calculations within Quantum Electrodynamics (QED), the theory that describes how light and matter interact. In particular, a detailed comparison between the masses of the proton and the antiproton offers a stringent test of the fundamental symmetry of the Standard Model, the so-called charge, parity and time (CPT) invariance. This proton lightness could also potentially shed light on other mysteries, such as the well-known discrepancies in the measured mass of the heaviest hydrogen isotope, tritium. The team at the Max Planck Institute for Nuclear Physics (MPIK) in Heidelberg and their collaborators from RIKEN in Japan used a device known as Penning trap, in which a combination of strong electric and magnetic fields, cooled to 4 degrees Kelvin (- 269.15 °C) is able to store individual protons and highly charged carbon ions. In this trap, the magnetic field forces the particles to move in circle and by measuring the characteristic frequencies of the trapped particles when they spin around, the mass of the proton follows directly.

Image above: The MPKI Penning-trap setup for precision mass measurements of single particles. A combination of strong electric and magnetic fields is able to store individual protons and highly charged carbon ions. (Image: Max Planck Institute for Nuclear Physics). The sensitive single-particle detectors were partly developed by the RIKEN group, drawing on experience gained with similar traps for antimatter research at CERN’s Antiproton Decelerator (AD). “The group around Sven Sturm and Klaus Blaum from MPIK Heidelberg that did the measurement has great expertise with carbon, whereas the BASE group contributed proton expertise based on 12 years dealing with protons and antiprotons,” explains RIKEN group leader and spokesperson of the AD’s BASE experiment, Stefan Ulmer. “We shared knowledge such as know-how on ultra-sensitive proton detectors and the ‘fast shuttling’ method developed by BASE to perform the proton/antiproton charge-to-mass ratio measurement.” Although carefully conducted cross-check measurements confirmed a series of published values of the proton mass and showed that no unexpected systematic effects were imposed by the new method, such a striking departure from the accepted value will likely challenge other teams to revisit the proton mass. The discrepancy has already inspired the MPIK-RIKEN team to further improve the precision of their measurement, for instance by storing a third ion in the trap and measuring it simultaneously to eliminate uncertainties originating from magnetic field fluctuations, which are the main source of systematic errors when using the new technique. “It is also planned to tune the magnetic field to even higher homogeneity, which will reduce additional sources of systematic error,” explains BASE member Andreas Mooser. “The methods that will be pioneered in the next step of this experiment will have immediate positive feedback to future BASE measurements, for example in improving the precision in the antiproton-to-proton charge-to-mass ratio.” The research was published on 18 July 2017 in Physical Review Letters: http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.119.033001 Note: CERN, the European Organization for Nuclear Research, is one of the world’s largest and most respected centres for scientific research. Its business is fundamental physics, finding out what the Universe is made of and how it works. At CERN, the world’s largest and most complex scientific instruments are used to study the basic constituents of matter — the fundamental particles. By studying what happens when these particles collide, physicists learn about the laws of Nature. The instruments used at CERN are particle accelerators and detectors. Accelerators boost beams of particles to high energies before they are made to collide with each other or with stationary targets. Detectors observe and record the results of these collisions. Founded in 1954, the CERN Laboratory sits astride the Franco–Swiss border near Geneva. It was one of Europe’s first joint ventures and now has 22 Member States. Related links: Antiproton Decelerator (AD): http://home.cern/about/accelerators/antiproton-decelerator BASE: http://home.cern/about/experiments/base For more information about European Organization for Nuclear Research (CERN), Visit: http://home.cern/ Image (mentioned), Text, Credits: CERN/Matthew Chalmers. Best regards, Orbiter.ch Full article

[antediluvian-microchip]

Whereas lazy evaluation just allows you to treat codata as data in some circumstances, but it's not a language feature, you just need to have coded it right so you don't go infinite?

I'm used to Rust being The Language that doesn't let me write bad code, and I'm just dipping my toes into Haskell, so it's neat to see a potential improvement on both I'd never heard of

programmers should be lazy, languages should be eager, Haskell’s elision of the difference between data and codata is a fundamental error and I will fight gently agree to disagree with anyone who argues otherwise.