#BFUHS | Explore Tumblr posts and blogs

etirabys · 1 month ago

Text

I obeyed the inscrutable exhortations of my soul about it and wrote an enemies to lovers RPF (real prokaryote fiction)

–

Cursed current! It flung me in the path of a jet of hot water exiting an underwater vent. The proteins on the hot-facing side of my cell wall denatured and cracked, and my lipid cell wall loosened for a fraction of a second.

I started to erupt my insides out, but something bumped into me – plugged the flow – and my membrane snapped back around the contaminant. I went sploing, and felt very, very odd. The edges of my more rigid cell wall fluttered in the turbulence, kept in place by proteins stitching wall to membrane, as I oriented myself.

I rode an eddy into a column of cooler water. It was still in me. No – not it – he. This was definitely a living, stormy little personality inside my membrane, agitated by the warmth of my cytoplasm and the density of organic compounds right outside his cell wall. He tried to push out his metabolic waste products out into me, even as mine trickled into him. “What is this? This place is death!” cried out the bacterium.

“Why did you careen into me?” I said, belligerent with my own fear and confusion. “I was minding my own business.”

“You rushed me. I couldn’t do anything about it – you’re three times bigger than I am,” he snapped. “It was like being hit by a silicate grain. Which would have been fine, because a silicate chip wouldn’t engulf me.”

“Engulf you! As if I did it on purpose!”

We lapsed into a long, miffed silence. I became aware that he was dividing. Using material in my cytoplasm!

I could do nothing about it. I couldn’t have torn open my membrane again to eject him even if I wanted to. I drifted, mending, pumping out the waste products of that mending.

It had been a long time since he and I had anything in common. We had diverged over a billion years, when the seas were hotter and more acidic. Some especially distant archaea were other to me, but bacteria were deep other. Occasionally I had extended a bridge to exchange genes with such deep others when it seemed advantageous, but I’d never before seen so intimately and extendedly how different a bacterium was from me. His cell membrane used right-handed glycerol and was held together with ester bonds, where mine used left-handed glycerol and used ether bonds. He thrummed with alien biochemistry. One of his fundamental energy converting proteins was turned the wrong way on his membrane. Repelled, I decided not to linger on it.

But soon his differences encroached upon mine in the most violent and personal way possible. After he divided, one of the copies died. When the dead one��s membrane broke, his genome came spilling out and smashed into mine.

Having his DNA mix in with mine was bad enough, but we both carried a small number of genetic parasites – genes just active enough to insert themselves into our genomes, and splice their RNA transcripts out before they were read into proteins. Mine were reasonably adapted to me, and knew how where to insert themselves to not wreak havoc.

But his didn’t. They cut themselves into my genome randomly, and failed to seal it up back into a ring when they were done, breaking up my genes into straight, uneven pieces.

“Bfuh! Gnah!” I was truly cross now. “Can you not splitting do that?”

“What, die in a hostile environment?” the remaining bacterium said sarcastically. “Because there isn’t enough food? Well, archaeon! You have my deepest apologies!”

Infuriated, I started cloistering my genome in a protective wreath of lipid bags to mitigate the next invasion of genetic garbage. Which came, again and again. I myself divided repeatedly, hoping each time to find myself in a body with no copies of him. A few of such versions of me were indeed free, and drifted away – to an unclear fate. We were by now all burdened with a cluttered genome that would would need time to pare itself down.

All of us naturally lost genes. The ones who did (and survived the loss) divided faster, because we used less energy on transcribing them into proteins. We periodically gained new genes from small trade with neighbors who seemed healthy. But given the extent of the bloat, it was unclear we’d lose the extra sequences fast enough before our burgeoning energy needs drove all of us extinct.

…although something interesting was happening: the obverse genetic sickness was being forced upon him. He was in reproductive competition against himself (in me! disgusting!). Versions of him that pared down their genome, as always, reproduced faster and outnumbered the others. Normally a creature that lost too many genes would just die, but… you see, I was making the proteins he would normally make, since his genes had gotten tangled up in mine. And being inside of me was so stable that many of the genes that adapted him for more heterogeneous environments dropped away harmlessly. He was getting… really sleek, and small, and hot – several entire Kelvins hotter than me at this point.

More and more, what he was doing was just making ATP – sucking up protons until his exotic ester-bonded membrane glowed with a potential as intense as lightning, and spitting them out through tiny protein motors embedded in his membrane to make energy.

Which I could use, too.

Which I, in fact, had to use. Not having ATP was dangerous, but having too much of it was dangerous too. I used it to make all those extra proteins coded by the DNA he was stuffing my genome with, of course. But I also got bigger. I knit the cloud of lipid bags around my genome into something sturdier, a complete seal between the inside where DNA was transcribed into RNA, and the outside where RNA was translated into proteins, so I had more time to splice out the garbage from the RNA before it was translated.

And it still wasn’t enough. He burned brighter and brighter as his needs pared down (while his energy production remained constant). I had to use it for something. Out of sheer self defense I made a cytoskeleton with all that spare energy. It let me make different shapes, on purpose, with myself.

“Huh,” he observed, seeing this. “You could engulf more stuff on purpose, if you wanted to. By… er… using yourself to pinch around them.”

“I have had enough experimentation with engulfment to suit me for four planetary lifetimes, thank you very much,” I said icily, but in the end I was too curious. I tried it. I found some small wiggling creature too ignorant of my new capabilities to know she should flee, and wrapped myself around her until her insides came spilling out into me for me to repurpose.

I was dazzled and a little frightened. What was that? She had just been minding her business and I had come along and destroyed her for my benefit. I had… I needed a new word for what had just happened… I had eaten someone. What had I become?

I floated, despising myself and despising him (although I admit a part of me admired him for how immediately he had seen the application of the new cell structure). I wished dearly that I’d eaten him instead, that I’d successfully punctured and destroyed him instead of harboring him –

(but if you had, you’d be lonely)

Lonely? The notion hit me like a bubble of turbulence. What was lonely? It was an inverted notion: solitude and independence, but bad, somehow. Ridiculous. He had done nothing good for my existence since he entered it, quite literally.

I could not help but notice most of us big, doubled-up creatures died. I was relieved when I met any cousin of myself. It was some sign that our existence might be viable. We were rocketing along some grotesque evolutionary path that seemed untrodden for a reason.

If I were to die there was no future for him either. And at this point I would die too if he did. Our fates were one.

“Listen,” he said, one of those times I smelled a cousin – another doubled-up creature with a colony of little no-longer-quite-bacteria – and started instinctively following her chemical trail. “I’m going to say something crazy, but hear me out.”

“Fine,” I said.

“We’re going to go extinct because our genome is too big. Even if we’re working well in some ways, we’re bound to have other things that are going wrong, just because we have so many genes.”

"Not crazy," I said. There was no longer rancor in my agreement. I could not blame him anymore for the genomic bloat. Will all the energy to go around I’d found myself adding structures of my own, all sorts of shamefully decadent specialized vesicles that I would never have considered in my old life. And the larger I’d grown the more space there was for him to proliferate in me, filling the interstices and giving me even more energy. There were hundreds of him in me now.

“When you meet that next cousin, line up your genome with hers – your entire genome – and trade copies. If it doesn't fit you might have to do a bit of a merge, which will be scary, but –”

“This isn’t,” I started suspiciously, and stopped.

“What?”

“This isn’t a ploy to come into contact with a new population you can trade genes with, is it?”

There was a truly hurt silence, during which ATP continued to flood out of his tiny, hot, electrically charged bodies to power my cellular processes. An involuntary reaction upon which I was now utterly dependent.

“Oh, come on,” I said. “Is it so offensive of me to ask? You’re trapped in me, you have no opportunity to meet anyone of your own kind except for clones. It’s been many years of this barely-life for you. It would only be natural.”

“I don’t need to meet anyone new,” he snapped. “I’ve accepted that this is my lot now, and I have to do novel things to survive it. Have you?”

We did not speak for a while. When I caught up with the cousin, I dawdled before brushing up against her, gripped by fear of more existential change. But I didn’t want to be a coward and I knew I’d been a cad to my little guest.

I extruded a conjugation pilus out towards the cousin, and pushed genetic material through it. Except this time I wasn’t sending just a few genes, but a full copy of my genome.

She was astonished, and a little reluctant. She almost cut the connection several times before she made up her mind: she opened a second connection and pushed through a copy of her own.

“Fair’s fair,” I said, and took it.

Like me, this cousin had a collection of straight chromosomes, a legacy from the initial damage from the genetic parasites. It took a bit of work to capture every single strand and bring it into my nucleus.

The differences between us were nontrivial; we must have diverged a while ago. Now what? Express both sets of genes, halving the ATP expenditure per gene? I supposed so. Nothing particularly dramatic happened.

When it was time to divide, I copied both genomes. My little guest spoke. “Once you're done, divide up the genes into two piles.”

“In the original combinations?”

“No, of course not. Do it randomly.”

So I sorted the genes into two groups and an hour later I had a sister, not a clone, who took half of the mitochondrial population. We drifted together for a bit, sizing each other up. After a while it became clear she was the fitter. Even though this made me the loser, I was happy. We had made something better, rather than simply waiting and hoping.

“We must do this again,” I told her. “We must all start doing this now, carrying two copies and exchanging one of them. This way we'll stumble faster on good ways to be arranged. Perhaps we can all survive.”

Truthfully, neither of us were optimistic. There was nothing else like us in the whole ocean. If we were the only ones in a niche, and we hadn’t been in it for long, it was natural to assume it wasn’t a good one to be in. But we drifted apart, and the practice spread, because the next time I met a cousin-creature, she knew what it was all about and proffered a whole copy first.

But some hundred thousand years later, sex was more universal among us than had once ever seemed reasonable, and we were still alive. Not just alive, but gloriously and healthily alive. I was humbled enough by the results to say, earnestly, “You were right and I was wrong. Thank you.”

My little tenant hummed in pleased acknowledgment, lighting me up. There were now thousands of him dotted throughout me. His genome was nothing but a dozen proteins. Mine, on the other hand, had tens of thousands – and that felt fine. I brimmed with more decadent vesicles than ever, all serving a justifiable function. "I forgive you," he said simply.

I had once seen him as a parasite. Now I felt like an ungainly oafish thing feeding off him. We had proliferated beyond our wildest hopes; there had been so many of us doubled-up creatures now, for so long, that some of us could not meaningfully swap genome-halves. We were too different. This was unheard of – even bacteria and archaea, which had diverged almost at the beginning, could swap gene pieces.

“I’ve been wondering how I can ever make it up to you,” I said.

“You are home to me,” he said. “I am content with it.”

I took his word for it, but I remembered what he had done for me, and I kept thinking. A billion years later some distant bacterial cousin that had cracked using water (water!) for energy had been so long at work that the ocean could not hold more of its byproduct, oxygen. It was a potent, nasty little gas but we had over the years acclimated over and over, and not died of it. After so much not dying from it, I’d been turning around in my head the notion of using it, coming up with an idea of how it might be done. It was my turn to make a bold proposal.

“To breathe it? How do you mean?” he asked.

I showed him.

It took many years, but he was patient, and acceded to powering my experiments. Eventually I was a colony of myself, anchored to the sediment in nutrient-rich waters with calm currents. Information and fuel thrummed through connected copies of myself. Other lifeforms drifted by in the water and sometimes settled on us. Almost too tiny to register, even though some of them were thousands of times larger than my little tenant and I had been when we came together.

I was a frondthing now, towering colossally above the quartz-speckled dolomite mud of the seafloor. Large and studded with sensors all over my surface – not my cell surface but my metasurface, my skin – I could feel the ocean. Not as one vector carrying me from one place to another, but as a collection of multidimensional movement – fast or slow, cold or hot, silty or clear, turbulent or laminar, acidic or alkaline.

The billions of hot, charged sparks of him permeated my body as I extended the drifting sheets of myself to sift the water for hydrocarbons and sulfides to feast on. A meter tall; the biggest and most spectacular creature that had ever existed. Being alive, I thought contentedly, feeding him sugars and fatty acids, couldn’t get more magnificent than this.

Apparently mitochondrial endosymbiosis (when a cell of lineage Archaea engulfed a cell of lineage Bacteria, and they together became the ancestor of all eukaryotic life) probably happened only once

I think by some axes this is the most epic, romantic thing that has ever happened. I kind of want to redesign my wedding ring

#eti reads the vital question #infinite monkey

652 notes · View notes

ambitiousbaba · 4 days ago

Text

BFUHS Recruitment 2024 for Programmer & Other Vacancies

BFUHS Recruitment 2024 – 10 Programmer & Other Vacancies Baba Farid University of Health Sciences, Faridkot (BFUHS) has released the notification for the recruitment of the Post of Programmer, Psychiatric Social Worker & Other with 10 Vacancies. Candidates can check the eligibility criteria from the official notification and apply Online between 30 October 2024 to 19 November 2024. Here we are…

0 notes

vedantbhoomidigital · 12 days ago

Text

BFUHS Senior Resident & Junior Resident Recruitment 2024 Job Posts 212 Vacancies

BFUHS Senior Resident & Junior Resident Recruitment 2024: The Baba Farid University of Health Sciences (BFUHS), Faridkot has published a job advertisement for Senior Resident & Junior Resident Vacancy on its official website. Check here for information on how to apply for the BFUHS Senior Resident & Junior Resident Recruitment 2024, as well as the age limit and qualifications required. BFUHS,…

0 notes

californiadailyreview · 29 days ago

Text

#news #breaking news #trending #google trends #job news

1 note · View note

crusum · 2 months ago

Text

फरीदकोट, पंजाब में 400 मेडिकल ऑफिसर पद, Organization Name: Baba Farid University of Health Sciences (BFUHS). पद का नाम: चिकित्सा अधिकारी। पदों की संख्या: 400. Location: फरीदकोट, पंजाब। ऑनलाइन आवेदन करने की अंतिम तिथि: 10 सितंबर, 2024 Apply. at. https://crusum.com/job/bfuhs-recruitment-medical-officer/

#www.bfuhs.ac.in2024 #www.bfuhs.ac.invacancies2024staffnurse #BFUHS #BFUHSRecruitment2024StaffNurse #Vacancies2024StaffNurseLastDate #BFUHSRecruitment2024Notification #BFUHacinVacancies2024StaffNurseResult #BabaFaridUniversitylatestNewsRegardingExams

0 notes

fresherjobwala · 2 months ago

Text

BFUHS Medical Officer Recruitment 2024 - 400 Vacancies (Last Date Extended)

The Baba Farid University of Health Sciences (BFUHS), Faridkot has announced a recruitment drive for 400 Medical Officer (General) posts. The last date to apply has been extended until 10/09/2024. Below is the detailed information about the recruitment process, important dates, eligibility criteria, and application procedures. Basic Information Department: Baba Farid University of Health…

0 notes

immigrationvisaservices · 5 months ago

Text

Baba Farid University of Health Sciences Faridkot

What is an Online Transcript Service?

An online transcript service allows students and alumni to request official transcripts electronically. This means they can submit their requests, pay fees, and receive their transcripts online, without having to visit the university in person. BFUHS has implemented an efficient online transcript service, which has simplified the transcript request process for its stakeholders.

Factors to Consider for BFUHS Online Transcript Service

Convenience: One of the most significant advantages of BFUHS online transcript service is its convenience. Students and alumni can request transcripts from anywhere, at any time, using a computer or mobile device with internet access. This eliminates the need for in-person visits to the university, saving time and effort.

Speed: The online transcript service at BFUHS is designed for efficiency. Once a transcript request is submitted and processed, transcripts are typically delivered electronically to the recipient within a short period. This rapid turnaround time is beneficial for students and alumni who require transcripts urgently.

Cost-Effectiveness: The online transcript service at BFUHS is cost-effective for both the university and students. By automating the transcript request process, the university can reduce administrative costs. Additionally, students can save money on postage and other expenses associated with traditional transcript requests.

Security: BFUHS online transcript service ensures the security and confidentiality of student records. Transcripts are delivered electronically through a secure portal, protecting them from unauthorized access or tampering. This enhances the integrity of the transcript request process.

Accessibility: The online transcript service at BFUHS is accessible to students and alumni worldwide. Whether they are located in India or abroad, individuals can easily request transcripts and have them delivered to their desired destination. This accessibility is especially beneficial for international students and alumni.

User-Friendly Interface: BFUHS online transcript service features a user-friendly interface that is easy to navigate. Students and alumni can quickly submit transcript requests, track the status of their requests, and receive notifications regarding their transcripts. This intuitive interface enhances the overall user experience.

Integration with Academic Systems: The online transcript service at BFUHS is seamlessly integrated with the university’s academic systems. This integration ensures that transcript requests are processed efficiently and accurately, reducing the likelihood of errors or delays.

Compliance: BFUHS online transcript service complies with relevant regulations and guidelines related to transcript issuance. This ensures that transcripts issued through the online service are official and recognized by academic institutions and employers.

Conclusion

In conclusion, the online transcript service at Baba Farid University of Health Sciences Faridkot offers several important benefits for students and alumni. From convenience and speed to cost-effectiveness and security, the online service has transformed the transcript request process, making it easier and more efficient for all stakeholders. As BFUHS continues to innovate and enhance its online transcript service, students and alumni can expect further improvements in the future.

Online Degree Transcript Service

Academic Transcript Service

University Transcript Service

Apply Transcript Service

>> >>

#immigration #academic transcription services #academic transcript #university transcript #online transcript

0 notes

sabhijobs · 10 months ago

Text

BFUHS Jobs Notification 2024: Apply Online for 111 Professor, Associate Professor, Assistant Professor Vacancies

#jobs #vacancies #govtjobs #recruitment

0 notes

gurunanakdev · 1 year ago

Text

Guru Nanak Dev Dental Best College in Punjab

Guru Nanak Dev Dental College (GNDDC) is a government dental college located in Amritsar, Punjab, India. It was established in 1969 and is affiliated to the Baba Farid University of Health Sciences (BFUHS). The college offers a 5-year Bachelor of Dental Surgery (BDS) program.

GNDDC is consistently ranked as the best dental college in Punjab. It has a well-equipped campus with modern laboratories and classrooms. The college also has a well-stocked library and a hostel for students.

The faculty at GNDDC is highly qualified and experienced. They are committed to providing students with the best possible education. The college also has a strong alumni network that can provide students with support and guidance after graduation.

GNDDC graduates are highly sought-after by employers. They are known for their excellent clinical skills and their ability to provide quality dental care.

Why is GNDDC the best dental college in Punjab?

There are a number of reasons why GNDDC is considered the best dental college in Punjab. These include:

High-quality education: GNDDC offers a high-quality education that is comparable to the best dental colleges in India. The college has a well-qualified faculty and a modern infrastructure.

Strong alumni network: GNDDC has a strong alumni network that can provide students with support and guidance after graduation. The alumni network can help students find jobs, get advice on their careers, and stay connected with other GNDDC graduates.

Job prospects: GNDDC graduates are highly sought-after by employers. They are known for their excellent clinical skills and their ability to provide quality dental care. GNDDC graduates can find jobs in hospitals, clinics, and dental schools. They can also start their own dental practice.

Affordability: GNDDC is one of the most affordable dental colleges in Punjab. The tuition fees are relatively low, and the college offers a number of scholarships and financial aid programs to students.

What are the admission requirements for GNDDC?

The admission requirements for GNDDC are as follows:

National Eligibility cum Entrance Test (NEET): Applicants must have passed the NEET exam with a minimum qualifying score.

Character and Medical Fitness: Applicants must be of good character and medical fitness. They must also have a valid passport.

Personal Interview: Applicants will be required to appear for a personal interview.

What are the career options after graduating from GNDDC?

GNDDC graduates have a wide range of career options available to them. They can work as dentists in hospitals, clinics, and dental schools. They can also start their own dental practice. In addition, GNDDC graduates can also pursue careers in research, teaching, and administration.

Conclusion

GNDDC is the best dental college in Punjab. It offers a high-quality education, has a strong alumni network, and provides excellent job prospects for graduates. If you are looking for a dental college in Punjab, GNDDC should be your top choice.thumb_up thumb_down upload Google it more_vert

1 note · View note