#Ara-C
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An ‘Uncommon early lineage switch’ in an MLL rearranged adult B-lineage Acute Lymphoblastic Leukemia to Mixed-phenotypic acute leukemia (B/Myeloid) by Narendra Agrawal in International Journal of Clinical Images and Medical Reviews
Case Report
Lineage switch is an infrequent phenomenon with an incidence of ~ 0.6% of all de novo leukemias and seen in almost 6% of relapsed cases. This phenomenon is observed following therapy or at the time of relapse. Switch in lineage tends to occur in younger patients and is associated with particularly poor outcomes.[1]
https://ijcimr.org/wp-content/uploads/2022/01/Fig-1__1_.jpg
Discussion
Our clinical report illustrates an adult refractory B -ALL with t (4;11) (q21;23), AF4:MLL fusion who transformed to Mixed-phenotypic acute leukemia;KMT2A-rearranged during his second month of therapy. Lineage switch in MLL rearranged paediatric ALL is common, but in adults it is not well reported. During the literature review, we found 2 cases of adult ALL harbouring t (4;11) transformed to AML [1,4]. First case illustrated chemotherapy responsive MLL rearranged B-ALL who underwent allogeneic stem cell transplantation (Allo SCT) in remission after induction therapy, who transformed to AML post 100 days of Allo SCT[4]. Second case illustrated refractory MLL rearranged B-ALL adult that rapidly transformed to AML following initiation of blinatumomab therapy [1]. However there was no case found to have switched from B acute lymphoblastic leukemia to Mixed-phenotypic acute leukemia;KMT2A-rearranged .Mechanism for lineage switch in MLL rearranged acute leukemia is not clear yet. Reports showing a strong trend of lineage switch involving B and myeloid lineages suggest that B myeloid progenitor might be involved in the mechanism of lineage switch. Studies reporting lineage switch post anti CD19 therapy; blinatumomab and CD19 chimeric antigen receptor (CAR-T), further advocates this theory [3].In our case it is not possible to state that transformation occurred post Venetoclax therapy, as flow cytometric evaluation was not done prior to start of venetoclax therapy. Development of secondary AML as a result of therapy related process can be ruled out in view of early lineage switch (< 6 months of therapy) and consistent finding of the t (4;11) (q21;23) at diagnosis of B-ALL and transformation. The (4;11) rearrangement detected at diagnosis, and phenotypic switch suggests that the original clone harboured a bi-lineage potential. If further genetic studies including NGS or gene expression studies done at baseline could have predicted the bi lineage potential is also unclear as the case reported by Haddox C et al did not show any change in the baseline NGS and the NGS performed during relapse.In conclusion, haematologists should be cognizant while treating MLL rearranged B -ALL adults for a lineage switch. It also underlies the importance of repeat evaluation of the disease if there is no response to standard therapy.
Declarations
Funding Funding information is not applicable to this study.Conflict of Interest All authors declare no conflict of interest to declare.Compliance with Ethical Standards Ethical Approval Statement: All authors stated that the study has been approved by the appropriate institutional review board and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.Acknowledgement We are thankful to our RGCI & RC staff of department of Hematology for their constant supportFor more details: https://ijcimr.org/editorial-board/
#Lineage switch#phenomenon#ALL#Mixed leukemia lineage#acute lymphoblastic leukemia#AML#MLL#acute myeloid leukemia#CD#chemotherapy#dysfunction syndrome#Ara-C#Narendra Agrawal
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bunch of signalis doodles
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Hc that grian used to play the hit game D4DJ back in the yhs series to cope with the things that were happening and still plays it to this day on hermitcraft 😋😋
#kuuyoooo..orwtv#yhs#yhs grian#grian yhs#yandere high school#hermitcraft#grian#c!grian#d4dj#d4dj groovy mix#is this some weird projection? maybe who knows#but what we do know is that grian's favourite character is maho!! and his favourite group is happy ara!! :3#is this another projection? maybe :3
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i genuinely love characters never forgiving each other so much! Especially if the other is redeemed or sympathetic or even a good person who fucked up. Like yes sweetie stay a petty bitter bitch, sometimes healing includes a dash of Resent and Remember
#empty thoughts#post s8 au#c&ai au#Ngl this is about my aus#Ps8!Kuron never forgives ps8!Allura Shiro and Keith#And ps8!Allura never forgives Lotor Honerva and Zarkon#C&ai!team never forgives Lance or Keith even if they do care miss and love them#And C&ai!Lance never forgives the team even if he misses and loves and cares about them#Ara never forgives Keith and has given up on him even if they understand#Kid never forgives Keith and there is no love there
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the want to put something in your story because it would be so cool but it contradicts the lore or messes it up in some other way
#moonstone screams into the void#irsewyn training ara would be so fucking cool#but a) irsewyn is very dead#b) luthralani wouldnt let that happen#c) it would overlap luthralanis and brigits role#kill the pious#ocposting
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#çağatay ulusoy#cagatay ulusoy#İçerde#icerde#aras bulut İynemli#aras bulut iynemli#just being the cutest things to have ever lived i guess#turkish fc#turkishfc#c: berat yalaz#brotp#brotp inspo#not to be dramatic but#might be the love of my life
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@boomermania sent: ♡ Basil for Arabella Hahahha
Send ♡ to see what my muse thinks of yours
○○○○○ | ATTRACTION ○○○○○ | AFFECTION ○○○○○ | INTEREST ○○○○○ | LOYALTY ○○○○○ | TRUST
You get nothing, Basil.
#&& asks / seeking what is true is not seeking what is desirable#boomermania#&& c. arabella / bloodied blossoms#thank you for the ask!#he has blown it with ara at this point kfbkgbf
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━━ next gen season 002◞ who's the anti-hero?.· ( @arabe )
if there was one contestant jiayi had been looking forward to meeting, it was ara. though they've greeted each other in the halls and given each other passing glances, that wasn't enough time to get to know each other properly. jiayi finds herself beyond excited when their names are called together, finally having the chance to work together.
everyone knows that the best conversations happen during downtime. while they take five minutes to rest, jiayi decides to strike up a casual conversation, trying to get to know the other better.
"you know, i did rhythmic gymnastics growing up," she tells the other, casually moving the scarf around in her hand, following the choreography but at a slower pace. "this isn't the same, obviously," jiayi laughs, looking over at ara. "but it reminded me of the ribbons we used to use for performances and stuff. i'm glad we get to use such pretty props for the finale."
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Should I wear a short without tights, like, just stocks going below my knees...
#i haven't shown a peace of skin from my leg since primary school help#it's gonna be over 22°C soo idk...#my top has Victorian vibe apparently... like I have a corset and short sleeves but... I don't know what it's called but a little pulled up#bref.#idk#my knees and the ara just above are exposed lesifjdhz should I ???#mes blogs
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☭ || & @wonwars liked for a starter (natasha) !!
__________✧ A SMIRK CROSSES HER LIPS AS SHE WIPES A BEAD OF SWEAT FROM HER TEMPLE. it’s not often a sparring partner even causes her breathing to quicken, let alone demand sweat && hard earned effort ( but steve is a worthy opponent, another super soldier trained to be the best ) they are far more similar than most would believe. ❛ don’t take it too seriously, rogers. you took that last hit like a champ. maybe you’ll win our next match. ❜
#c; natasha romanoff#wonwars#(( ARA MY LOVE I HAVE MISSED YOU ))#(( also she's an asshole and i love her ))
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"i agree with you. it's also different than what i had expected. though, i guess i'm not sure what i was supposed to have expected after next gen, " jiayi says, confiding in ara. she's sure there are other people here who were trainees at different companies like she was, but she doesn't know if they've all experienced the same as she has. "i didn't really understand why we were thrown into a workshop so suddenly, i thought there would be sort of . . . " the dancer trails off, biting her lip while looking for the right words. "an adjustment period."
"i'm getting the hand of it though," she tells the other with a smile. "after all, it's kind of sink or swim, you know?" jiayi laughs. "you have to come out of it on top or else," she jokes around with the other, waiting for her to give her take.
"its been...." honest? slight under-exaggeration? don't express the woes? "different from what i expected in some ways, but also what i expected when i thought about what it is to be a trainee. but i guess that might be different under every company, yea." what ara means is, she doesn't know how much she actually is on route with the acting bits, but hey, everyone has to start somewhere.
"how about you? getting the hang of everything?" she's happy that she gets to see her here, and perhaps they could always 'keep up' with each other that way, especially since they'd worked together well, along with friendly competition that kept them on their toes. being a trainee from square one had put a lot into perspective for ara. and it was good to see how far others were, especially the trainees that had been here for a longer time to see where their progress was. of where she could hopefully approach one day.
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TAC
sauropoda is a clade of saurischia that includes some of the largest dinosaurs we currently know of. if i'm going to submit something to you it's going to include these guys. they include some familiar faces like the brontosaurus. but the largest specimen within this group is a giant barosaurus fossil.
credit to Paleonerd01 on DeviantArt
they've inhbabited every continent (including Antarctica!) and give us those comically large prints we're so fond of zooming out on.
another good giant friend of mine is the colossal squid. why do they keep making bigger squids? because i love them. i love their huge eyes and big fights with sperm whales. i love their elusiveness. i love that we went "kraken?" haha very funny. cthulhu? sure guys. and they EXIST <333
credit to Te Ara in New Zealand
and charismatic megafauna are cool and all but have you considered something a little smaller? maybe a Black Capped Chickadee? they tend to travel in groups or two or more when they're flying outside the nest and their call "chicka dee" functions as a warning call of increasing intensity depending on how many "dee"s they add.
and bugs? here's the thing: i have fought with Polistes metricus for years growing up. have they stung all of my loved ones? absolutely. do they also eat an invasive species of worm in my area? yes. and while these guys will sting you without a second thought and fly away laughing, they are a necessary evil. just like the birds, they stop for a sip of water. they are, i must admit through gritted teeth, an important part of my ecosystem.
ATT
String identified: TAC
aa a ca aca tat c t agt a ct . ' gg t t tg t t' gg t c t g. t c aa ac t ta. t t agt c t t g a gat aa . ct t a01 atAt
t' at ctt (cg Atactca!) a g t cca ag t ' g t .
at g gat t ca . t ag gg ? ca t. t g a g gt t a. t . tat t "a?" aa . ct? g. a t T <333 ct t T Aa aa
a caatc gaaa a c a a t a c tg a tt a? a a ac Ca Cca? t t t ta g t t' g t t t a t ca "cca " ct a a ag ca cag tt g a "" t a.
a g? ' t tg: a gt t t tc a gg . a t tg a ? at. t a at a a c aa? . a t g tg tt a c tgt a aa agg, t a a ca . t t , t t a at. t a, t at tg gtt tt, a tat at ct.
ATT
Closest match: Acipenser ruthenus genome assembly, chromosome: 41 Common name: Sterlet sturgeon
#tumblr genetics#genetics#asks#requests#sent to me#all-0f-the-above#fish#ocean#sturgeons#sterlet sturgeon#giant squid#squids#yet another organism that does not look real
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Chat how do i make an absolutely horrendous ass hairstyle from feathers? It's for an oc
#c&ai au#I just want to keep the tradition of Keith's family having terrible haircuts#I am finally designing Kid and Ara#And yes I am looking up raptor fursonas for ideas#But also Shitty hairstyles for Kid#I don't want to give her bowlcut even I am not that cruel#Fringed buzz cut (with ponytail) and frosted tips have potential though#Also whatever the fuck Nami's mom was doing. Ngl she pulled it off well
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How would each ro act after the first morning after waking up next to mc?
FINALLY tackling the old asks! Sorry for taking a while everyone :^3
✦ How do the LIs act after waking up next to the MC for the first time
✦ Amon: Gives the MC a casual "Mornin'" while stretching. He's not a morning person at all so he hugs the MC from behind and buries his face on the crook of their neck, breathing them in. He falls asleep soon after and doesn't let the MC leave the bed.
✦ Raeya: She wakes up before the MC, a bit disorientated. She has to take her time just trying to make sense of her emotions as she watches the MC breathe. She doesn't wake the MC up and goes on about her duties, leaving a letter behind for the MC.
✦ Gael: He's fast asleep, a rare occurrence. He looks so peaceful with the timid morning sun caressing his face. Then his lashes flutter open and he looks at the MC with a smile, lifting a hand to lovingly brush their cheek. "You look heavenly," he mumbles.
✦ Envy: The MC has to wake them up because damn he's sound asleep and he's holding the MC too tight—! They're, of course, terribly flustered and grumpy about being woken up and having been caught in such a position. "C-can't you see I'm trying to sleep? Go away if you are bored."
✦ Ara: She wakes the MC up with kisses, tickles and a bit of wrestling! She's so so happy to have spent the night with the MC and she wants them to know. She wants nothing but to just lay around for a bit and talk, enjoying a lazy morning!
✦ Xal: He's mortified. He doesn't know what he's supposed to do now—he never expected to get this far to begin with. He has to act cool but doesn't know what to say or do, wants to touch the MC but is afraid of waking them up...So he just lays there, still and barely breathing, watching them sleep.
✦ Father Pride: Gently wakes the MC up with kisses. It all comes natural to him. "It is morning, my dear," he whispers in their ear. "There are things I must attend to."
✦ Lázaro: They're already up and about, preparing breakfast. Their hair is a mess, their pajamas are a mess...They're not used to waking up this early, but they want to do something romantic for their first morning with the MC.
✦ Cécile: Most likely didn't sleep. He instead spent the whole night watching the MC closely, careful of every breath they take, feeling them alive next to him. Probably has touched the MC's lips or hands to see them react in their sleep. When the MC wakes up, he's already up, dressed, and completely fresh.
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Snow and Rose
𝐅𝐚𝐧𝐟𝐢𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐃𝐞𝐦𝐨𝐧 𝐒𝐥𝐚𝐲𝐞𝐫 Female reader
Warnings : Murders. Violence.
𝐒����𝐍𝐎𝐏𝐒𝐈𝐒
❛ 愛 ❜
He was filthy. Made to be discard and dislike and disgust hence the reason he even did not dare utter the pure words of love to the one he grew to not dislike however it all changed when he saved a woman. An peculiar one with taste of adressing herself as a snow and him, a disfigured man—rose
It was the first night of the winter. Crimson petal of rose slowly fell atop of the untainted white snow. To be honest the blush fall on the snow looked breathtaking. So beautifully vast yet together by nature almost seem like the destiny also choose in the harshest winter will bear the most adored rose to be seen.
The first time she saw them, it was unsuited together yet now if this was her last image of the world's beauty before withering away. She is thankful enough, smiling under the cold whiteness where she lay, drenched in her blood surround her and pain numb little by little. Now that her vision fading she wish to indulged the nature of destiny more. She wish to find her own rose in the snow, a lover she meant and perhaps children too. ? How odd of her to even question of her own wish to bear children when she knows no rose is there for her.
As the roses always wirther, unsuited to the snow like she thought, no one likes snow. Even those who believed to like only do for few weeks, months not years, certainly not decades.
Snow as beautiful is cold, far cold she realize after embracing in the ground, blush of her skin drying and tears gather to flow silently.
How she wished to see the sunrise for the last time. One last time before passing to void of nothing, she knew heaven and hell were only words for fear to do good despite being surround by hell. One last tear roll down as she embrace the death when a crunch of foot earned her sight.
Eyes rolling to see the demon, the culprit of her death towering surprise to feel the drop of crimson. Not one from the rose petal rather of blood along stench of someone's death coloring the sliver sword he holds. He who is not the demon her mind knows at least, however an stranger wrapped in black cloth like the void of night and white cloth wrap around his mouth with snake rest upon his neck. His eyes, Unusual she ever seen one teal and another yellow.
His gaze bore at her, laying on the snow and blood circle around her like an painting of death with petals of rose fallen near her forehead almost seem like an crown of farewell flowers. She looks utterly and hauntingly beautiful he is afraid to say the rose suit her with the snow. Even her tears of sorrow paint her beautiful. His eyes locked on those (E/C) eyes that he forgot it's close and pale hue cover her entirity.
Like a bleak of a man his knee bend down, fingers almost curl refuse to taint the body by brushing his filthy touch yet with gentle he never grace one with did he hold her, cold sweep into his warmth and her body in his hand vulnerably he embrace her clothed part more to begin walking the path of his home where many also lives.
Pain greet her awake, her sight met with the white ceiling of a house than the void of nothing she expected. The pain in her body told her the answer of her life. She is alive and the beautiful nature of rose met snow was not her last image of mother earth's beauty nor the man she viewed.
The man in question is none where to seen when the door slide open stand a beautiful woman, smiling gently. "She must like butterfly". (Y/N) judged from the hair pin of butterfly to her dress print.
"Ara, Ara, you are awake. I see". (Y/N) bow to the woman despite the pain in her stomach yet her face remain unchanged. Stoic as before. "Do not distress yourself further. I fear your present state is one of considerable pain." The woman came closer to find indeed the blood taint the white again.
(Y/N) apologize softly.
"No apologies necessary, I assure you." Her laugh was melodies that the man almost slip her mind.
"Oh. A man, with snake around his neck ?" She continue, her eyes as if reliving the time. "Have you seen him ?" The actions of that woman's hand pause and staring at those purple eyes oddly seem empty and lost.
"I do. He is one of the demon slayers". Strange words. Demon slayers and demons. Both belonged to monstrous fairytales she never liked to read and now very real to see, one was eater almost pushed her to the edge of life and another an savior, retrieve her life yet both interwoven with one another.
"Oh. Would you be so kind as to inform me of his whereabouts, that I may pay my respects ?" The woman stare at (Y/N). No human she ever seen so indifferent to the word demon. One must bear some hatred or kindness or any emotions linked. Never indifference. Perhaps the lack is what present her so different however naïve to the laws of world.
"You may, he will be found next door, precisely where the wounded gentlemen resides." Her finger point to near the door of (Y/N)'s right and she nod.
"Thank you". She stood to the woman's surprise and walk with difficulty to the next door, sliding open to find three young lads on the bed with another beautiful woman with pink hair and that man. That man's soften gaze saw her bend her body to bow and utter the words she truly felt from the core of her heart.
"Thank you for saving me" . The tone and the face remained unchanged however those eyes he notice was pure, clearance with courage Obanai swears. Courage he won't be rewarded, not with the blood in his veins.
"It was my duty". He replied, turning away from her and she left quietly. All were too suprise to intervene the tight tension darting from the unknown to the cold demon slayer. He who thought their first words exchange to be the last.
However here she is, sitting beside Tanjiro, applying herbs like the gentle caress of a mother to his wounds he receive from Obanai during their period of training. A furrow appear in his brows, why is she here ? His eyes slide to the stomach cover by her cloth and by movements of her body she appears to be healthy.
Soon he learnt after she recovered did she request to dedicate herself to nursing she was by experience and Shindou welcomed her. What a play of destiny he thought watching intently how with unchanged poise she clean one gruesome wound than previous.
"How calm". He wonders, how can a woman be so devoid of expression ? Even Shinobu plaster a smile and here she is, and was at her last breath crafted the same expression.
"I offer my sincerest gratitude, your expertise is truly remarkable." Tanjior in his cherry voice smiled large and she returned only with a nod. He narrow his eyes, was she also poise in front of the culprit of her death ? Or did she cried, begged or perhaps— .
"The gentleman is cleared to depart." Her words directly to the older demon slayer and he nod, averting gaze with someone first because of how unashamed they were. He took him alongside and wish to never view her.
What a foolish thing to pray when she is at his each sight. One time brooming with the little girls despite them playing, laughing and joining her hands to round each other she only played along unchanged as if her soul was not present while her body was.
Another time dusting and cleaning the injury manor and he was there, yet not once she glanced or tries to word with him. Not that he desired so rather finding her like an puzzle. So locked unlike Mitsuri who is like the sun, bright and bathed in pureness and free like an open book he can read. Even that butterfly demon slayer seem easier to understand than she. A lady with unfamiliar origin, name he didn't care to learn and expression never change.
Upon another occasion, a youthful trainee, gravely injured, was brought forth, his face snarl in pain and half his form scorched by the ravages of fire yet she didn't so little flinch. She beheld the charred flesh, and with unflinching resolve, set about healing the wounds. It made him wonder again would she grasp, be horrified or pity the demon slayer if she shown her the scar in his— shaking such filthy words, he walked down that time.
"(Y/N) hurry, the Serpent Hashira and the Wind Hashira needs help !" She pause in her hurried steps. Her savior was in need and the thought to return the debt come to her mind. Her feet went to the room watching the two strongest demon slayers swallowing pain as they lay on the bed. "One of the demons poisoned them so the little wounds are deadly".
Her trembling hands took the medicines and herbs, as being advised she about to touch the Serpent Hashira, he wield his sharp sword to her chin, little inches away and his snake hiss. "Don't come near me". His words tender yet the sentences chilling sharp and she can not help ponder why.
"What ? we don't have male—".
"Let me do my own". He cut the argue he finds not needed.
"However you have no knowle—". Kanao tries to change his mind for good.
"I can!" he asserted, the crimson-tinted the binding around his mouth and voice bending into whisper with his pale skin whiter. (Y/N) is afraid the poison rushing faster.
"By all means, proceed. But heed my caution: observe my movements, then replicate, lest harm ensues. Do you understood ?" Obanai who never thought her to spoke nod and took the medicines and clothes. (Y/N) note the wounds are in his arm, thigh and shoulder thus she walk beside him to another silent room—she assume his room and sat, turning face away to hear the shuffles of clothes unraveling and she begin to show on her clothed body while he remain silent, save for the occasionally groans and strainted huffs.
"Completed". She nod and he finally turn his eyes at her back, wondering why she is unmoved.
"May I see your work, that I might judge its merit ?" She hoped to have yes however deep inside the answer was spoken in silent already.
"No". No. As she expected and nod to maneuver towards his clothed self and about to stand at her feet when Obanai narrow his eyes in displease. That expression and lack of words. Always of few words, indifference and unafraid. All of the qualities he wished he had within himself. Indifference of other's eyes, unafraid of the past and courageous.
Implused by his deranged thoughts and in daze of his wound. "Would you be scared of this ?" Uncaring he rip the binding of his mouth, the cool breeze brush against the dreadful scar that is still fresh in his memory. His eyes close like the binding was a relieve of pain however he waited. For a strangling scream, disgust grasp, pity words or anything. Save for the errie silence.
Each muscle of his body tense at the feel of an soft touch at the corner of his lips and his hand shoot up holding her wrist and eyes wide to be face at her expression. And indeed it was not in vain.
Alas, the rosy flush that painted her entire visage, and the demure shimmer in those crystalline eyes, told a tale he had not expected to behold. Even her skin blushed from his touch alone.
A hatred twist his inside as he swing her hand and yelled harsh. "Get out !" She flinch and run out. His head buried in his palm, he did not intent to yell, however what could he had done if that bewitching woman's expression did not just brew a hope in his heart. A hope no one did and he himself dare not aknowledge.
"What was that ?" Bewildered he erased her image of blush.
He must have frighten her because the few days later she was none of his sight and it was unknown how he felt so he walked to his room when the moon's shine lighten on the letter slide to the gap of the door. His finger touch the paper and read. 'To the respected Serpent Hashira. From (L/N) (Y/N).'
An name he is unfamiliar could only belonged to that woman. "(Y/N)". The name roll down his flesh, sounding hauntingly pleasant. He grip the paper hard and went inside. First he sit and grab the candle near the paper he almost wish to burn, not read any words behind the paper. Still his curiosity drive him to open and unfold the smooth lines of paper.
'You might have forgetten what had occur to the day of your injury yet I do not and thus the letter was crafted, whether view it as an unworthful letter or cowardly one, it's your choice however I won't delay your time and say the words I had not courage to utter in front of you that the scar you showed me was in my view an scar of loathe, pain and sorrow of the past because the way it's craved could not be done willingly—' Obanai turn away from the paper, unwelcomed memories slit his mind and fill his vision.
"Useless". He deemed the paper and the fire of the candle so close however something, perhaps hope convince him to read further.
"My intention was not to recall your unpleasant memories however I had to because the next words I say might desire you to kill me even hate me I fear, because your wound blossoms red like the petals of rose, breathtakingly beautiful, so beautiful that I was mesmerized. I am wretched for holding dear and falling in love with the sorrow you might have, the very thing I am in love is the one you hate, so please it's not a letter of forgiveness because do not forgive me. Do not forgive me ever".
His hand fell limp as fingers still grip on the paper become tighter than ever and the candle's light illuminate his fiery blush face and the glistening rims of his eyes betrayed a depth of feeling he could hardly grasp.
"Is it not a confession ?" His other palm cover his face and brush upon the binding that for the first time did not evoke feelings of revulsion and disgust rather sentiments he had not felt for anyone, not even the love Hashira. Because the unpleasant memories dissipated the moment his scar made contact, replaced by her passion words, which floated in his vision like ethereal whispers.
At the early rise of the sun Obanai ran to the butterfly manor to find her not Kanon who raise a eyebrow and continue her duty.
"Might I inquire as to the present location of Miss (L/N) ?" His question made her confuse before sighing.
"Good heavens! You haven't heard ? She resigned, having met my elder sister in person and left a letter for us all, though, alas, it reveals nothing of her destination." Her voice somber reflections on the departure of the benevolent lady, whom she had not had the opportunity to bid farewell, a circumstance that pained her, much like her sister.
The words save for the resigned tune out. The sounds distant and dishonest. H-how could it ? How could it be ? When she confessed her love merely yesterday ? "The letter ? May I see it ?" She hand over the paper he unfold to read and yes, it's her farewell for eternal. How cruel, she left. He almost threw the paper in fit of rage but he knew better and did not.
She is one cowardly woman he ever met.
☯
A red rose.
The first single rose appear at (Y/N)'s doorstep was few weeks later she moved from the demon slayer's corps to a small village little further from the branch and the house she stay was bearable and decent food was nearby to attend. The real reason she left was due to the passion confession her heart forced her hand to give however when she comes to realize the man she was giving and his profession was, she decide to separate herself.
Because the man would never love her back and his profession was oath to death, no sense of life was guaranteed and she swears the heartbreak of future could not stitch the patchs of broken heart.
From childhood she watched her mother obedient like a pet to her father and never replied back and his father always remained gentleman and cold. Very different than the fairytales she dislike yet reads for the sake of befriending others.
Soon growing up she realize because of the unspoken law of marriage. A wife is a doll of his husband who married for the sake of duty. They were not in love instead tied down in duty where she, the child was a bond they had to create by society's pressure and sheding her innocence to adulthood, it's her time to take the role of doll for someone else.
And at first few men did choose her, some even confess their love but after few months they left, giving the ring of their betrothed away.
"Your demeanor is as frigid as the grave. How might I be expected to harbor affection for one so seemingly devoid of vitality?"
"(Y/N), I must confess, it pains me to consider the possibility that you do not return my ardent affections. Your demeanor suggests a certain...indifference towards me."
"Miss (L/N), though I have always held your beauty in the highest esteem and affection however our spent time leads my heart yearns for a deeper connection. I confess, I covet a love that stems from genuine attachment, not mere obligation."
"If your heart truly beats for mine, then demonstrate your affection through tender compassion ! Speak words of endearment, that I might be assured of your love !"
Some were good, some were spoiled and some greedy yet what common in them was their speech of words of how cold she is and like snow she is beautifully admired—not loved. To be honest she hated all the men that left her, even if some were really good she loathe them. Why ? Because none tried to know the dept of her love for them because she did love them, each and every one of them. Yes ! not as deep as the love of Zhi Nü for Niu Lang. Still she did, what she couldn't was to express them. She simply does not know. Words were not easy to utter as she wanted and affections never surface properly.
Also their love was not worth if they left so easily leading her to become spinster and out of roof as for her family's reputation she was a staint so she left, no cries, pleads or any attachment. What prevails her is that quiet tears still roll down.
Leading her at the first night to encounter a hungry demon and that man, she for and realize after viewing his scar. He awoke a whole world inside her she was hidden from and now she can not help wonder if she had known him better could she bear courage to court him.
Red rose on top of the snow. Her sight snap to the ruby hue and turn to the vase inside the house already had seven more red rose rest. Adding this will be seven. It's strange no one comes to mind who would give her flowers like a secret admirer. Like confessing secret love to her.
With steps that softly crunched above the winter's white blanket, she approached the flower, its beauty unmarred by frost's chill grasp. Her fingers enveloped its slender stem free of thorns. The rose errierly remind her of him. His beauty of an rose and sharp gaze of thorn to protect. Perhaps thus she collect the roses.
☯
Slap !
Embracing her new role as a cleaning worker in the village proved daunting for her. As both a woman and alone seen beneath of men after all.
"Your defiance has cost us dearly. You should have layed your body at the customer's whims equals to a king's demands, were left unfulfilled. Your stubbornness has turned gold to dust. You ungrateful witch !" The pain at her cheek throb and she lowered her head, choosing silence, closing eyes to feel the next and next until the wife of the owner hold his hand.
"Oh dearie, this is a noodle shop. Not a brothel, what she had done is right because imagine rumors spreading of our humble restaurant turning into selling women. How bad is it not ?" His wife in tender voice trap him in sprouts of nonsense and he, halting and debating the words.
(Y/N) gratitude the lady in mind and caught sign of her hand twisting towards exit. "Go out". With eyes darting in secretion (Y/N) bow to her and quietly walked away from the unfair abuse and her night shift.
☯
Chirps of bird and noise of hens awake her and ignoring the ache in her cheeks she walk to the door and her eyes wide and mind in confusion.
She blink once, twice and slowly, very slowly walk on the snow to the center where a folded man's cloth is layed above blood with a rose on the side. The eighth rose. Her (E/C) eyes stare at the cloth for moments before walking to the noodle owner's house that is few walks away and not long a cry of agony rip out.
Her walk slow down and she watched the crowd form and the wife's cries in her corpse husband's body that is naked and blood sweeping from the stabs in his stomach and dried blood from the hole of his either cheeks. Pity bleed within (Y/N) for the newly widow— not the man. He deserved it and a happiness bloom thinking how length of love her secret admirer bear.
She went to her yard again and the cloth vanish and blood buried leaving the rose and a letter. "Was he here ?" A shiver ran her spine, glancing around to spot only to be failed and she read the letter.
'I am not good with words however what I am good is at welding swords and that man deserve equally as the demon heads' Demons. Holding the rose at one and letter at another, finally one man comes to her mind. The serpent demon slayer.
And she is unaware what to do and if her thought is even true.
☯
"Leave me !" (Y/N) yelled to the previous customer of the noodle shop who she was beated for and now tormenting her at night of street. "I said leave me !" She screamed attracting heads of the crowd letting the man loose his grip and her chance to escape.
Ninth rose lay beside the cloth of a man painted in blood. She walked out of her yard at the early morning and roam to find his body calmly and the crowd forming told her already. She close the gap, catching glimpse of his naked body layed to be humiliated and stabs in his stomach and holes on his palms where the man grip her by.
And as she expected when she return to her yard, the cloth was erased, blood buried and rose with letter repeating the same words.
☯
"It must be you ! You wretched woman, you got my husband killed ! After being bewitched by you, was he killed ! It must be you". The wife of the man yesterday murdered she was not even aware married came to her doorstep at midnight, screaming and throwing scornful words she does not like.
"I do not, mam". Calmly and unchanged she answered, attempt at closing the door she mistake to open and when the wife caught hint of that, (Y/N) felt a rush of coldness at her face. Numb snow cold her warm body as (Y/N) part her lips to say she was thrown more snow and more and more.
Until a wet slick sound and sudden stop of snow lead her head to turn meeting the scene of a sliver sword pierced the wife's stomach and glide back gushing blood and her body limp at once revealing Obanai, the serpent hashira standing with a blank expression and when met with (Y/N)'s, did it sparkle the beauty of emotions.
Her eyes also saw in his another hand holding the rose. Tenth rose. "At the tenth rose I decided to finally meet you". Loudly he confessed. Both to being the secret admirer and the murderer however not a hint of fear he felt not because he considerate himself powerful rather at the mercy of her love. While he thought he loved the love Hashira, (Y/N) mold the very love to him. While the love hashira was the shining sun, pure and out of his reach stem from pure respect, (Y/N) plant the seed of love from the mere words of his scar he loathe, she turn the hatred and self-disgust of the scar marred his skin into a memory of their sweet love. With the words of her and blushful image of her touched his corner lips brew him the feel of worthy to loved and love. She made him feel human.
Now at each touch of his mouth, rather than ashamed and scared did his heart skip beats at her face, at each touch of his mouth reminds him of her words. The confession of her yearning and passion he never received from one before and she graced him so deep, he could not help fall deeper, running to every village from small to huge at search of her and when found the relieve of bliss remind him once again how unable of her he has no life of his own anymore.
"Forgive me, Miss (L/N). I could not force you to my will defying yours so all I could do was remove the obstacles and wait for your return to me as I have fallen for you deeply". At each step closer to her he said each word and finishing he give her the rose, waiting to see her accepting or throwing.
Fear gripped his heart to be honest a little— no, a lot, the fear of rejection from the woman he holds dearly to his heart will crush him however he will wait, as long as needed and continue removing the filth from her life. Flith that forced his hand and deserved to be united with the demons.
Oh, how sweet. (Y/N) couldn't believe. A man who go length beyond for her and love her to the end without leaving is an heaven. Even more when it's the same man she did not even dare dream of loving her back holding rose for her and bloody sword to others.
How could she resist such love. An love scary and undeserving at other's view is her everything.
Her finger grasp the rose and lean forward to press a kiss the man above his binding who's those unusual beautiful eyes wide only to soften. Her lips parted and said. "Forgive me not I am in love with you".
"Forgiven because I am in too". He returned blooming a smile on her lips. Language of love she heard once, love that not only utter from words alone however also from actions of service for their love. Perhaps this man has that.
FIN
𝐀𝐑𝐂𝐇𝐈𝐕𝐄 𝐨𝐟 ◸◜𝐋𝐨𝐯𝐞 𝐋𝐚𝐧𝐠𝐮𝐚𝐠𝐞𝐬 ◞◿
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