#Apixaban

[mcatmemoranda]

You have to decrease the dose of Eliquis if pt is less than 60 kg, over 80 y/o, has reduced renal function. A mnemonic is ABCD, Age greater than or equal to 80, Body weight less than or equal to 60 kg, creatinine greater than or equal to 1.5, Double of these factors. Halve dose to 2,5 mg bid.

[sybiochem]

Learn how Apixaban helps manage Atrial Fibrillation by reducing stroke risk and improving heart health. Explore benefits and usage today.

[medicomunicare]

Bleeding out of the tumor: not only informations, but bad prognosis for patients as well

Cancer and the hemostatic system are tightly interconnected, and a hemostatic imbalance is frequently observed in patients with cancer. Clinical manifestations of this interaction may occur as both thrombotic and bleeding complications. Previous research has predominantly focused on thrombotic issues associated with cancer, such as venous thromboembolism (VTE) and arterial thromboembolic events,…

[janineluciaa]

Order Your (Apixaban) Eliquis Online & Experience the Difference

Learn the suitability of ordering your (Apixaban) Eliquis online and elevate your healthcare experience. With just a few clicks, access a wide range of health product from the comfort of your home. Enjoy swift deliveries, reasonable prices, and the reassurance of quality. Embrace the future of healthcare with seamless online health products services.

[healthcaretechnologynews]

Taking a closer look - Oral Anticoagulants

Oral anticoagulants are utilized in treatment of many cardiovascular indications like NAVF, AF, DVT, PE and stroke.

Warfarin and Apixaban are most recommended treatments and Pfizer, Novartis, Bayer, and Merck are the biggest players in the space. The key considerations that influence therapy choice are efficacy, safety, frequency of monitoring and cost of the drug.

The most important unmet medical needs in the space are gaps in diagnosis and optimizing quick diagnosis, Delays in treatment start due to long waiting time for specialists’ appointment, and low drug adherence.

To address the unmet needs pharma companies, regulatory bodies are undertaking many initiatives including digitalization, implementing AI in diagnosis equipment etc.

Write to us at enquire@grgonline.com to learn how GRG Health is helping clients gather more in-depth market-level information on such topics.

Oral anticoagulant like warfarin, NOACs are utilized in treatment of many cardiovascular indications like NAVF, AF, DVT, PE and stroke. Patients seek medical attention from GPs or Specialist due to pre-existing illness. Most common symptoms of NVAF patients are high blood pressure, Chest pain, irregular heartbeats, and shortness of breath; and most common symptoms of DVT patients are pain, swelling and clot in legs.

For diagnosis the basic tests conducted are ECG, Blood tests, blood pressure tests and ultrasound, as per the set protocol of Hospitals followed by GPs and Specialists. Warfarin and Apixaban are most recommended treatments and Pfizer, Novartis, Bayer, and Merck are the biggest players in the space. The key considerations that influence therapy choice are efficacy, safety, frequency of monitoring and cost of the drug.

We think that the most important unmet medical needs in the space are gaps in diagnosis and optimizing quick diagnosis, Delays in treatment start due to long waiting time for specialists’ appointment, gaps in effective communication between Physicians and Specialists, lack of awareness, lack of manpower, Lack of advanced diagnostic tools, and low drug adherence.

To address the needs regulatory bodies, Pharma companies and patient associations have undertaken many initiatives which involves digitalization (e.g., mobile apps), educating patients via seminars, campaigns and raising awareness at national, regional and local level and implying conventional methods like enhancing effective communication through electronic medium and implementing anti-coagulation alert cards etc.

We think that smooth collaboration between the primary and the secondary care to avoid delay in referral and treatment start, thereby speeding up the process of screening and hence preventing the risk of stroke can be one of the most important futuristic approaches to improve quality of care. Others can be using Application based diagnostic tools or devices or Advanced technology like mobile app, wearables, powerful ultrasounds, X-ray, or body scanners that can improve patient outcomes and patient care management by improving testing, diagnosis, providing quick results and enhancing drug adherence.

Application enabling initial screening of the patients with AF on the basis of age or prevailing medical condition. Artificial intelligence incorporated in the diagnosis equipment for analyzing the condition with minimum artifacts and accurate results can also help in improving patient outcome.

Visit our website now: https://www.grgonline.com/

[phonemantra-blog]

Eliquis Side Effects: What You Need to Know In the realm of anticoagulant medications, Eliquis has become a common choice for preventing blood clots and strokes. While Eliquis can be highly effective, it's crucial to be informed about its potential side effects to ensure safe usage. In this article, we'll delve into the world of Eliquis side effects, covering both the common and more serious ones, and provide valuable insights on how to manage them. Common Eliquis Side Effects Eliquis is known for its efficacy in preventing blood clots, but like all medications, it may come with some side effects. Understanding the common side effects is essential for those prescribed this medication. Bleeding Episodes: One of the most frequently reported side effects of Eliquis is bleeding, which can manifest as nosebleeds, bruising, or prolonged bleeding from minor cuts. While these side effects are typically mild, it's essential to keep your healthcare provider informed. Gastrointestinal Distress: Some individuals may experience digestive issues like stomach discomfort, indigestion, or diarrhea while taking Eliquis. These symptoms are generally manageable but should be discussed with your healthcare provider if they persist. Minor Headaches: Headaches, while less common, can occur as a side effect of Eliquis. They are usually mild and tend to resolve on their own. However, if headaches become severe or persistent, consult your healthcare provider. Serious Side Effects While Eliquis is generally well-tolerated, there are rare but serious side effects that require immediate medical attention. It's essential to be aware of these and seek help if any of them occur: Severe Bleeding: If you experience excessive or uncontrollable bleeding, such as heavy nosebleeds, blood in urine or stool, or prolonged bleeding after minor injuries, it's critical to contact your healthcare provider or seek emergency medical care. Allergic Reactions: Although uncommon, allergic reactions to Eliquis can occur. Symptoms may include skin rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing. If you notice any of these signs, seek immediate medical attention. Liver Problems: Eliquis can, in rare cases, affect liver function. Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unexplained fatigue. If you experience any of these symptoms, contact your healthcare provider. Managing Eliquis Side Effects While Eliquis side effects are generally manageable, it's essential to be proactive in addressing them: Open Communication: Maintain open and regular communication with your healthcare provider. Inform them of any side effects, even if they seem minor. Follow Prescribed Dosage: Adhere to the prescribed dosage and schedule provided by your healthcare provider. Do not adjust the dosage without consulting them. Report Unusual Symptoms: If you notice unusual or severe symptoms that could be related to Eliquis, do not hesitate to contact your healthcare provider. It's better to seek professional advice promptly. Risk Factors and Precautions Certain factors may increase the likelihood of experiencing side effects from Eliquis. It's essential to be aware of these risk factors and take precautions accordingly: Age: Older individuals may have a higher risk of bleeding while taking Eliquis. If you are elderly, your healthcare provider may adjust your dosage or monitor you more closely. Medical History: Inform your healthcare provider about your medical history, especially if you have a history of bleeding disorders, liver disease, or gastrointestinal issues. This information will help them make informed decisions about your Eliquis prescription. Interactions with Other Medications: Eliquis can interact with other medications, including over-the-counter drugs and supplements. Always disclose all the medications you are taking to your healthcare provider to avoid potential interactions. Alcohol and Eliquis: Limit or avoid alcohol consumption while taking Eliquis, as alcohol can increase the risk of bleeding. Symptoms to Watch For Vigilance is key when taking Eliquis. Be mindful of any symptoms that may indicate potential side effects. These may include: Unexplained Bleeding: Any bleeding that cannot be attributed to an injury or known cause should be taken seriously. Allergic Reactions: If you experience skin rash, itching, swelling, or difficulty breathing, seek immediate medical attention. Jaundice: Yellowing of the skin or eyes (jaundice) could indicate a potential problem with your liver function and should be reported promptly. When to Contact Your Doctor Knowing when to contact your healthcare provider is vital for managing Eliquis side effects effectively: Severe or Prolonged Bleeding: Contact your doctor immediately if you experience severe or prolonged bleeding, as this could be a sign of a serious issue. Allergic Reactions: Seek medical attention without delay if you suspect you are having an allergic reaction to Eliquis. Unusual Symptoms: Any unusual or severe symptoms that you believe may be related to Eliquis should be discussed with your healthcare provider. Eliquis Side Effects FAQs   Q: What are the common side effects of Eliquis? A: Common side effects of Eliquis include bleeding, gastrointestinal discomfort, and minor headaches. Q: Are there any serious side effects associated with Eliquis? A: Yes, Eliquis can have serious side effects, such as severe bleeding, allergic reactions, and liver problems. Q: How can I manage minor side effects of Eliquis? A: Managing minor side effects may involve open communication with your healthcare provider and following their guidance. Q: What should I do if I experience severe bleeding while on Eliquis? A: If you experience severe or uncontrollable bleeding, seek immediate medical attention. Q: Can Eliquis cause allergic reactions, and what are the symptoms? A: Eliquis can rarely cause allergic reactions. Symptoms may include skin rash, swelling, and difficulty breathing. Q: Are there specific risk factors for experiencing side effects from Eliquis? A: Age, medical history, and interactions with other medications can be risk factors for side effects. Discuss your history with your healthcare provider. Q: Can alcohol worsen Eliquis side effects? A: Yes, alcohol can increase the risk of bleeding while taking Eliquis. Limit or avoid alcohol consumption. Q: What are the symptoms of liver problems that may be associated with Eliquis? A: Symptoms of liver problems include jaundice (yellowing of the skin or eyes), dark urine, abdominal pain, and unexplained fatigue. Q: When should I contact my doctor about Eliquis side effects? A: Contact your doctor immediately if you experience severe bleeding, allergic reactions, or unusual and severe symptoms while on Eliquis. Q: How can I monitor my symptoms while taking Eliquis? A: Pay close attention to unexplained bleeding, allergic reaction symptoms, and any unusual or severe side effects. Report them to your healthcare provider. Conclusion Understanding Eliquis side effects and how to manage them is crucial for those who rely on this medication for preventing blood clots and strokes. By staying informed about potential side effects, following precautions, and promptly reporting any concerning symptoms to your healthcare provider, you can use Eliquis safely and effectively. In the following sections, we will delve deeper into specific side effects and provide further guidance on Eliquis usage.  

[aimarketresearch]

Apixaban Market Size, Share, Trends, Demand, Growth and Competitive Analysis

Data Bridge Market research has recently issued comprehensive industry research on Global Apixaban Market which includes growth analysis, regional marketing, challenges, opportunities, and drivers analysed in the report. The market insights gained through this Apixaban market research analysis report facilitates more defined understanding of the market landscape, issues that may interrupt in the future, and ways to position definite brand excellently.

An analysis of competitors is conducted very well in the reliable Apixaban Market report which covers vital market aspects about the key players. Moreover, the report gives out market potential for many regions across the globe based on the growth rate, macroeconomic parameters, consumer buying patterns, their preferences for particular product and market demand and supply scenarios. It gives significant information and data pertaining to their insights in terms of finances, product portfolios, investment plans, and marketing and business strategies. Detailed market analysis has been performed here with the inputs from industry experts.

The market is projected to observe major growth during the forecast period. Apixaban is generally indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. The recommended dose of Eliquis is 5mg orally twice a day. Apixaban is available in the market in both capsule and tablet form. The development of advanced anticoagulants increases the demand and provides numerous options to patients and healthcare professionals.

Access Full 350 Pages PDF Report @

Highlights of TOC:

Chapter 1: Market overview

Chapter 2: Global Apixaban Market

Chapter 3: Regional analysis of the Global Apixaban Market industry

Chapter 4: Apixaban Market segmentation based on types and applications

Chapter 5: Revenue analysis based on types and applications

Chapter 6: Market share

Chapter 7: Competitive Landscape

Chapter 8: Drivers, Restraints, Challenges, and Opportunities

Chapter 9: Gross Margin and Price Analysis

Key Questions Answered with this Study

1) What makes Apixaban Market feasible for long term investment?

2) Know value chain areas where players can create value?

3) Teritorry that may see steep rise in CAGR & Y-O-Y growth?

4) What geographic region would have better demand for product/services?

5) What opportunity emerging territory would offer to established and new entrants in Apixaban Market?

6) Risk side analysis connected with service providers?

7) How influencing factors driving the demand of Apixabanin next few years?

8) What is the impact analysis of various factors in the Global Apixaban Market growth?

9) What strategies of big players help them acquire share in mature market?

10) How Technology and Customer-Centric Innovation is bringing big Change in Apixaban Market?

Key players operating in the global apixaban market include:

F. Hoffmann-La Roche Ltd. (Switzerland)

Mylan N.V. (U.S.)

Teva Pharmaceutical Industries Ltd. (Israel)

Sanofi (France), Pfizer Inc. (US.)

GSK plc (UK.)

Novartis AG (Switzerland)

AstraZeneca (UK.)

Johnson & Johnson Private Limited (US.)

Sun Pharmaceutical Industries Ltd. (India)

Merck & Co., Inc. (US.)

Bristol-Myers Squibb Company (US.)

Lilly (US.)

Amgen Inc. (US.)

Eisai Co., Ltd (Japan)

Aspen Holdings (South Africa)

Fresenius Kabi AG (Germany)

Nanjing Jianyou Biochemical Pharmaceutical Co., Ltd. (China)

OPOCRIN SPA (Italy)

SARIA International GmbH (Germany)

Hepalink Group (China).

Shenzhen Techdow Pharmaceutical Co., Ltd (China)

Yino Pharma Limited (China)

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[covid-safer-hotties]

Patients With Long-COVID Show Abnormal Lung Perfusion Despite Normal CT Scans - Published Sept 12, 2024

VIENNA — Some patients who had mild COVID-19 infection during the first wave of the pandemic and continued to experience postinfection symptoms for at least 12 months after infection present abnormal perfusion despite showing normal CT scans. Researchers at the European Respiratory Society (ERS) 2024 International Congress called for more research to be done in this space to understand the underlying mechanism of the abnormalities observed and to find possible treatment options for this cohort of patients.

Laura Price, MD, PhD, a consultant respiratory physician at Royal Brompton Hospital and an honorary clinical senior lecturer at Imperial College London, London, told Medscape Medical News that this cohort of patients shows symptoms that seem to correlate with a pulmonary microangiopathy phenotype.

"Our clinics in the UK and around the world are full of people with long-COVID, persisting breathlessness, and fatigue. But it has been hard for people to put the finger on why patients experience these symptoms still," Timothy Hinks, associate professor and Wellcome Trust Career Development fellow at the Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre senior research fellow, and honorary consultant at Oxford Special Airway Service at Oxford University Hospitals, England, who was not involved in the study, told Medscape Medical News.

The Study Researchers at Imperial College London recruited 41 patients who experienced persistent post-COVID-19 infection symptoms, such as breathlessness and fatigue, but normal CT scans after a mild COVID-19 infection that did not require hospitalization. Those with pulmonary emboli or interstitial lung disease were excluded. The cohort was predominantly female (87.8%) and nonsmokers (85%), with a mean age of 44.7 years. They were assessed over 1 year after the initial infection.

Exercise intolerance was the predominant symptom, affecting 95.1% of the group. A significant proportion (46.3%) presented with myopericarditis, while a smaller subset (n = 5) exhibited dysautonomia. Echocardiography did not reveal pulmonary hypertension. Laboratory findings showed elevated angiotensin-converting enzyme and antiphospholipid antibodies. "These patients are young, female, nonsmokers, and previously healthy. This is not what you would expect to see," Price said. Baseline pulmonary function tests showed preserved spirometry with forced expiratory volume in 1 second and forced vital capacity above 100% predicted. However, diffusion capacity was impaired, with a mean diffusing capacity of the lungs for carbon monoxide (DLCO) of 74.7%. The carbon monoxide transfer coefficient (KCO) and alveolar volume were also mildly reduced. Oxygen saturation was within normal limits.

These abnormalities were through advanced imaging techniques like dual-energy CT scans and ventilation-perfusion scans. These tests revealed a non-segmental and "patchy" perfusion abnormality in the upper lungs, suggesting that the problem was vascular, Price explained.

Cardiopulmonary exercise testing revealed further abnormalities in 41% of patients. Peak oxygen uptake was slightly reduced, and a significant proportion of patients showed elevated alveolar-arterial gradient and dead space ventilation during peak exercise, suggesting a ventilation-perfusion mismatch.

Over time, there was a statistically significant improvement in DLCO, from 70.4% to 74.4%, suggesting some degree of recovery in lung function. However, DLCO values did not return to normal. The KCO also improved from 71.9% to 74.4%, though this change did not reach statistical significance. Most patients (n = 26) were treated with apixaban, potentially contributing to the observed improvement in gas transfer parameters, Price said.

The researchers identified a distinct phenotype of patients with persistent post-COVID-19 infection symptoms characterized by abnormal lung perfusion and reduced gas diffusion capacity, even when CT scans appear normal. Price explains that this pulmonary microangiopathy may explain the persistent symptoms. However, questions remain about the underlying mechanisms, potential treatments, and long-term outcomes for this patient population.

Causes and Treatments Remain a Mystery Previous studies have suggested that COVID-19 causes endothelial dysfunction, which could affect the small blood vessels in the lungs. Other viral infections, such as HIV, have also been shown to cause endothelial dysfunction. However, researchers don't fully understand how this process plays out in patients with COVID-19.

"It is possible these patients have had inflammation insults that have damaged the pulmonary vascular endothelium, which predisposes them to either clotting at a microscopic level or ongoing inflammation," said Hinks.

Some patients (10 out of 41) in the cohort studied by the Imperial College London's researchers presented with Raynaud syndrome, which might suggest a physiological link, Hinks explains. "Raynaud's is a condition of vascular control or dysregulation, and potentially, there could be a common factor contributing to both breathlessness and Raynaud's."

He said there is an encouraging signal that these patients improve over time, but their recovery might be more complex and lengthy than for other patients. "This cohort will gradually get better. But it raises questions and gives a point that there is a true physiological deficit in some people with long-COVID."

Price encouraged physicians to look beyond conventional diagnostic tools when visiting a patient whose CT scan looks normal yet experiences fatigue and breathlessness. Not knowing what causes the abnormalities observed in this group of patients makes treatment extremely challenging. "We need more research to understand the treatment implications and long-term impact of these pulmonary vascular abnormalities in patients with long-COVID," Price concluded.

[mcatmemoranda]

Answering questions.

Patients taking apixaban for stroke prevention in atrial fibrillation should discontinue the medication for 1 to 2 days prior to a procedure without bridging. This approach is associated with a low risk of bleeding complications without increasing the incidence of thromboembolism. The choice between 1 and 2 days depends on the bleeding risk associated with the procedure.

For hypertensive emergency, lower the BP by 25% in the first hour.

[bluewindfall]

3 good things

Counseled a cute patient on apixaban :) I taught her the FAST acronym for stroke symptoms, and she managed to repeat it back to me at the end!

Talked to my manager. He was like how are rotations, and are you eating and sleeping well, all very sincerely. It was nice but I don't think he can help me haha

Forgot to bring my water bottle today, but I had an extra one in my car

[kinkykinard]

I’ll share one of my fails to help you feel better 😂

When I first started, my mentor asked my to get a drug from the drug trolley. I spent ages looking in the P section for “pixaban” because she asked me for a…pixaban.

She looked at me and pissed herself laughing.

Apixaban Jules…APIXABAN!

Okay but that's a GENUINE misunderstanding! It could've happened to any nursing student!

I spent my entire university career working very closely with drosophila because they're such a good model organism and somehow my brain pulled up an image of a fruit fly and went "diphtheria" lmao.

[janineluciaa]

APIXABAN (ELIQUIS®) INFORMATION FOR PATIENTS, FAMILIES & CARERS

APIXABAN helps to stop blood clots from forming. You need to tell your doctor or pharmacist if you are taking any other medicines. This includes any vitamins or minerals, herbal supplements or medicines you bought without a prescription from a pharmacy, supermarket or health food store. It is a good idea to carry an up-to-date list of all your medicines. Consider wearing a medical alert bracelet.

Swallow the tablet whole. You can take it with or without food. Your pharmacist can put APIXABAN in a dose administration aid, such as a Webster Pak®.

Take your next tablet as soon as you remember. Then continue your APIXABAN as usual. If it is nearly time for your next tablet, do not take extra tablets to make up for the forgotten tablet. If you miss more than one tablet, or if you are unsure of what to do, talk to your doctor or pharmacist immediately.

[waghaditi]

Anticoagulant Market Analysis Focuses On Regional Growth And Drug Development Strategies

The anticoagulant market is witnessing significant growth due to rising cardiovascular diseases, advancements in therapies, and increasing awareness about thrombotic disorders. This comprehensive analysis provides insights into the market's dynamics based on specified parameters.

Market Dynamics

Increasing demand due to the growing prevalence of cardiovascular diseases like stroke and deep vein thrombosis

Rising awareness about blood clot prevention and management among patients and healthcare professionals

Introduction of advanced therapies like direct oral anticoagulants (DOACs) with better safety profiles

Expansion in emerging markets fueled by improving healthcare infrastructure

Market Drivers

Growing geriatric population, which is more prone to blood clotting and cardiovascular conditions

Increasing adoption of novel anticoagulant therapies in clinical practice

Advances in personalized medicine and diagnostics for effective anticoagulation management

Rising incidence of atrial fibrillation, a leading cause of stroke requiring anticoagulant therapy

Market Challenges

High cost of new-generation anticoagulant drugs, limiting access for certain patient populations

Risk of bleeding complications associated with anticoagulant usage

Lack of universal access to advanced treatments in developing countries

Stringent regulatory requirements for drug approvals, which can delay market entry

Competitive Landscape

Dominated by major pharmaceutical companies like Pfizer, Bayer, and Johnson & Johnson

Emergence of new players focusing on innovative therapies to capture market share

Strategic collaborations and partnerships for research and development activities

Expansion of product portfolios through acquisitions and licensing agreements

Market Segmentation

By Drug Type

Direct oral anticoagulants (DOACs) like apixaban, rivaroxaban, and dabigatran

Vitamin K antagonists (VKAs) such as warfarin

Low molecular weight heparins (LMWHs) like enoxaparin and dalteparin

Unfractionated heparin (UFH) commonly used in hospital settings

By Route of Administration

Oral anticoagulants preferred for outpatient management

Injectable anticoagulants widely used in acute care and surgical settings

By Indication

Prevention and treatment of venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism

Stroke prevention in patients with atrial fibrillation

Post-surgical blood clot prevention

Regional Insights

North America holds the largest market share due to advanced healthcare systems and high adoption rates

Europe follows with strong demand for anticoagulants driven by aging populations

Asia-Pacific is the fastest-growing region due to improving healthcare infrastructure and increasing awareness

Latin America and the Middle East are emerging markets with significant potential for growth

Technological Innovations

Development of antidotes for newer anticoagulants to manage bleeding risks

Advancements in biosimilar and generic drug production to lower costs

Integration of artificial intelligence and machine learning for personalized therapy recommendations

Introduction of combination therapies for improved patient outcomes

Future Outlook

The anticoagulant market is expected to grow steadily due to the increasing burden of thrombotic conditions

Ongoing research on safer, more effective drugs with fewer side effects will shape future trends

Expanding access to affordable anticoagulation therapies in underserved regions will further boost market growth