#Allantoin Market Analysis

[heathcareforallworld]

Tumor Lysis Syndrome Market Growth Projections to 2032

Introduction

Tumor Lysis Syndrome (TLS) is a potentially life-threatening condition that occurs when cancer cells break down rapidly, releasing their contents into the bloodstream. This rapid cell lysis can lead to severe metabolic disturbances, including hyperkalemia, hyperphosphatemia, hyperuricemia, and hypocalcemia, which can cause acute renal failure, cardiac arrhythmias, seizures, and even death. With the rising prevalence of cancer and advancements in chemotherapy and targeted therapies, the incidence of TLS is increasing, prompting significant growth in the Tumor Lysis Syndrome market.

Market Size and Share

Tumor lysis syndrome Market Size was estimated at 13.77 (USD Billion) in 2023. The Tumor Lysis Syndrome Market Industry is expected to grow from 15.36(USD Billion) in 2024 to 36.725 (USD Billion) by 2032. The tumor lysis syndrome Market CAGR (growth rate) is expected to be around 11.52% during the forecast period (2024 - 2032)., attributed to the high prevalence of cancer, advanced healthcare infrastructure, and the presence of key market players. Europe followed closely, while the Asia-Pacific region is expected to witness the highest growth rate due to increasing healthcare investments and rising awareness about cancer treatment and associated complications.

Key Drivers and Restraints

Drivers

Increasing Cancer Incidence: The rising global burden of cancer is the primary driver for the TLS market. According to the World Health Organization (WHO), the number of cancer cases is expected to rise by 70% over the next two decades, leading to a higher incidence of TLS.

Advancements in Cancer Therapies: The development and adoption of novel chemotherapeutic agents and targeted therapies, which are highly effective in destroying cancer cells, increase the risk of TLS, thereby driving the demand for preventive and therapeutic measures.

Improved Diagnosis and Awareness: Increased awareness about TLS among healthcare professionals and patients, coupled with advancements in diagnostic techniques, is propelling market growth. Early identification and management of TLS are crucial for improving patient outcomes.

Restraints

High Cost of Treatment: The cost of medications and treatments for TLS, including hospitalization and supportive care, can be prohibitively high, limiting access, especially in low- and middle-income countries.

Adverse Effects of Treatment: The side effects associated with TLS treatments, such as rasburicase and allopurinol, can pose significant challenges, potentially limiting their widespread use.

Market Segmentation

The Tumor Lysis Syndrome market can be segmented based on treatment type, end-user, and region.

By Treatment Type

Pharmacological Treatment:

Allopurinol: A xanthine oxidase inhibitor used to prevent hyperuricemia.

Rasburicase: An enzyme that converts uric acid to allantoin, facilitating its excretion.

Febuxostat: Another xanthine oxidase inhibitor, often used as an alternative to allopurinol.

Supportive Care:

Intravenous fluids and diuretics to manage electrolyte imbalances.

Hemodialysis for severe cases involving acute renal failure.

By End-User

Hospitals: Major healthcare providers for TLS management, accounting for the largest market share.

Specialty Clinics: Increasingly important in providing specialized care and outpatient management of TLS.

Ambulatory Surgical Centers: Gaining traction for providing supportive care and treatment.

Regional Analysis

North America

North America dominates the TLS market due to high cancer prevalence, advanced healthcare systems, and strong presence of key market players like Sanofi, Takeda Pharmaceutical Company, and Novartis AG. The U.S., in particular, leads the region with extensive research and development activities and favorable reimbursement policies.

Europe

Europe holds the second-largest market share, driven by high healthcare expenditure, well-established healthcare infrastructure, and significant cancer incidence rates. Countries like Germany, France, and the U.K. are major contributors to market growth in this region.

Asia-Pacific

The Asia-Pacific region is expected to exhibit the highest growth rate during the forecast period. Factors such as increasing healthcare investments, rising awareness about cancer and associated complications, and improving healthcare infrastructure in countries like China, India, and Japan are fueling market expansion.

Latin America and Middle East & Africa

These regions are anticipated to witness moderate growth due to improving healthcare facilities and increasing cancer prevalence. However, challenges such as limited access to advanced treatments and high cost of care may impede market growth.

Industry Trends

Increasing Use of Biomarkers: The use of biomarkers for early detection and risk stratification of TLS is gaining traction, enabling personalized treatment approaches and improved patient outcomes.

Advancements in Drug Development: Ongoing research and development activities are focused on developing new and more effective treatments for TLS, with several drugs in the pipeline showing promising results.

Adoption of Telemedicine: The integration of telemedicine in cancer care, particularly for monitoring and managing TLS, is becoming more prevalent, providing patients with timely access to healthcare professionals and reducing hospital visits.

Competitive Landscape

The Tumor Lysis Syndrome market is highly competitive, with key players focusing on strategic initiatives such as mergers and acquisitions, collaborations, and product launches to strengthen their market position. Major players in the market include: Baxter International Inc., Fresenius SE & Co. KGaA ,Gambro AB ,Asahi Kasei Corporation ,B. Braun Melsungen AG ,Haemonetics Corporation ,Terumo Corporation ,NxStage Medical, Inc. ,Bellco S.r.l. ,Nikkiso Co., Ltd. ,RenalGuard Solutions, Inc. ,NxStage Kidney Care ,Medtronic plc ,JCB Biologics, Inc.

Forecast to 2032

The Tumor Lysis Syndrome market is poised for significant growth over the forecast period, driven by the increasing global burden of cancer, advancements in cancer therapies, and rising awareness about the importance of early diagnosis and management of TLS. The market is expected to witness technological advancements, improved diagnostic techniques, and the development of novel therapies, further propelling market growth.

Conclusion

The Tumor Lysis Syndrome market is experiencing robust growth, driven by the rising incidence of cancer and advancements in cancer treatment. With increasing awareness, improved diagnostic techniques, and ongoing research and development, the market is expected to expand significantly over the next decade. Stakeholders, including pharmaceutical companies, healthcare providers, and policymakers, must collaborate to address the challenges and leverage the opportunities in this dynamic market to improve patient outcomes and quality of life.

[divyankverma]

Allantoin Market Professional Survey Report 2020-2027: AMR

[market-researchm]

Allantoin Market Overview, Growth Demand And Forecast Research Report To 2022

The global Allantoin Market estimated to stretch till US$ 641.7 million by the year 2022. Growing demand for the product, required for the production of precautionary healthcare merchandises, due to its possessions such as soothing, anti-irritant, and moisturizing, is likely to motivate the progress of the market above the prediction period. The allantoin market is expected to develop by a CAGR of 6.1%.

The business is likely to observe greater development in the uses of cosmetics due to its greater demand for the production of bath, hair care, hand care, and face care merchandises. Increasing usage opportunity for the product, in oral care merchandises, for example toothpaste and mouthwashes is likely to take an optimistic influence on the progress of the business above the prediction period.

The division of the international market of Allantoin on the source of Type of Application could span Oral Cleanliness, Cosmetic, and Medicinal. The subdivision of Medicinal application is likely to be the speedily developing subdivision above the estimated period, due to its greater demand for the production of remedial ointments for the wound and the creams. The subdivision of Cosmetic application was responsible for the stake of more than 32.8% during the year 2016. It is likely to develop above the prediction period because of greater demand for the product for the production of sun care lotions, creams, and gels.

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The division of the international market of Allantoin on the source of Area with respect to Trades in terms of intake, Profits, Market stake and Development percentage could span North America [U.S.A], Latin America [Brazil], Europe [Germany], Asia Pacific [India, China], Middle East & Africa.

By the source of geography, Asia Pacific has ruled the business by means of by means of income in 2016, and was responsible for the market stake of 31.9%. The speedy development of business of cosmetics in the province, because of increasing per head earnings of the end user and altering standard of living is estimated to take an optimistic influence on the development of the business.

Due to the growing foreign investments by the overseas nations, in the field of medicinal and personal care in the area, the market of Allantoin in Latin America is estimated to develop by a CAGR of 6.4% above the prediction period. In the area of Europe, the allantoin industry is estimated to develop by a stable CAGR above the prediction period because of the deep-rooted cosmetics manufacturing, together with growing demand for allantoin centered cosmetic merchandises.

The constant and speedy development in the productions for example Oral Cleanliness, Cosmetic and Medicinal, in these areas, it is likely to motivate the demand for allantoin centric products for various applications. Furthermore, industrialized markets for instance the U.S.A and European markets are progressively improving from the financial downward spiral and are expected to create important demand for the allantoin in the approaching years.

The allantoin industry in the U.S. is estimated to come up by CAGR of 5.9% above the prediction period, this is because of the existence of various pharmacological companies in the area. Additionally, the existence of most important cosmetic products producing companies in the U.S.A, comprising Unilever, L’Oréal, and Procter & Gamble, is likely to take an optimistic influence on the progress of the business.

The statement revises Trades in terms of intake of Allantoin Market in the international market; particularly in North America, Europe, Asia Pacific, Latin America and Middle East & Africa. It concentrates on the topmost companies operating in these regions. Some of the important companies operating in the Allantoin industry on the international basis are Clariant and Ashland Inc. Additional noticeable companies operating in the field are: EMD Chemicals, Akema Fine Chemicals, Allan Chemical Corp. and Performance Materials.

Access Full Research Report @ https://www.millioninsights.com/industry-reports/allantoin-market

[dianarusco]

Allantoin Market will grow at a rate of 6.25% for the forecast period of 2021 to 2028 |Allan Chemical Corporation, Ashland, Akema Fine Chemicals, Clariant, Merck KGaA, RITA Corporation,

The Allantoin report displays the systematic investigation of current scenario of the market, which covers several market dynamics. 

Click Here to Get And Download Free Sample Copy of Allantoin Report @ https://bit.ly/3rBwVMs

[irispublishersagriculture]

Iris Publishers - World Journal of Agriculture and Soil Science (WJASS)

Nutrient Intake, Fermentation, Digestibility and Growth Performance of Barbarin Lamb Supplemented with Sweet Lupin

Authored by S Abidi

In Tunisia, particularly in the arid and semi-arid zones, climatic conditions have caused the degradation of rangelands leading to a chronic forage deficit and a nutritional imbalance in animals, particularly in sheep and goats. Thus, energy and / or nitrogen supplementation has become essential to maintain these animals and ensure the expected performance. For this reason, Tunisia has resorted to the import of raw materials including soybean meal, barley and corn [1]. However, fluctuations in their prices on the world market are negatively affecting animal nutrition industry. Our country imports annually, over 300,000 tons of soybean meal at a price of 1.2dt / kg [2]. Similarly, these imported raw materials are unstably available on the Tunisian market which can affect the profitability of farms and alter the sustainability of animal production sector in Tunisia. As a result, several attempts to replace these foods, including soybean meal, have been considered by researchers. Protein crops (Lupine, faba beans and peas) are good alternatives to soybean meal because of their high crude protein content. However, despite their good nutritional quality, their use in animal nutrition is currently limited due to the presence of anti-nutritional factors (Faba bean tannins, lupine alkaloids) and their fluctuating availability on the market (limited forage legume crops). Thus, the main objective of this study is the evaluation of the substitution effect of soybean meal by sweet lupine on the ingestion, digestion, growth and meat quality in Barbarine lambs.

Materials and Methods

Animals

Twenty-four six-month-old Barbarine lambs were selected. The initial live weight averaged 23 kg. These animals were transported to INRAT headquarters. They were acclimated for 4 days to new housing conditions. Lambs were weighed than divided into three equal groups. All animals received oat hay ad libitum and concentrate. the first group received CC1 containing 75% barley, 22.5% soybean meal and 2.5% CMV, whereas the second received CC2 containing lupine as a substitute for soybeans in term of CP to be iso-nitrogenous with CC1. The third group received intermittently CC2 and CC3 which contain only barley and CMV. Animals have undergone a growth period (80 days) followed by a digestible period (10 days).

Sampling

During growth period, average daily growth was assessed through weighing animals biweekly. At digestible period, lambs were housed individually in metabolic cages and were allowed three days for acclimatization to new conditions. Animals received weighed amounts of corresponding feed. A 7-day faecal collection period started on the following day. After weighing the amounts of fresh feed, refusals and faeces, samples of each were taken daily. Part of each sample was used for DM determination and the other part (20% of the weight of the fresh refusals and faeces) was stored at 4 °C for hay and concentrates or at – 5 °C for faeces. Urine was collected in plastic recipients containing 100ml of a 10% sulphuric acid solution (v/v) to maintain pH below 3. After weighing, an aliquot (10%) corresponding to each animal was taken and frozen (- 20 °C). In the last day, pooled samples of individual feed refusal, and faeces were dried at 50 °C; ground through 1 mm screen then stored pending analysis. Pooled samples of urine were stored in the freezer (- 20 °C) until analyzed. Rumen fluid was taken in two consecutive days to measure pH and ammonia content and to determine protozoa number.

Analyses

Feed, refusals and faeces samples were analyzed for dry matter (DM), ash and crude protein according to AOAC [3]. They were also analysed for (NDF, ADF and ADL) [4]. Urine was analyzed for Kjeldahl nitrogen [3] and allantoin concentrations measured using a colorimetric method. Urinary excretion of allantoin (Y, mmol/d) was used to calculate microbial purines absorbed (X, mmol/d [5]. Rumen fluid samples were analyzed for NH3-N [6].

Statistical analysis

The statistical analysis of the results was performed using an analysis of variance according to the model: Yijk = μ + Ai +εi.

In which μ= arithmetic mean; Ai = the effect of diet (i= 1,2 or 3) and εi is the residual experimental error. Data were analyzed using the ANOVA procedure. All statistical analyses were carried out using the GLM (general linear model) procedures of SAS Package (1987). Differences between the means of all the analyses were analyzed using the LSMEANS procedure.

Results and Discussion

Nutrient contents of feeds are presented in Table 1. Soyabean meal is greater in CP than lupine, while the opposite trend was observed for NDF, ADF and ADL.

Diets intake and digestibility are shown in Table 2. Results revealed that the nature of the additional protein source did not affect feed intake (P> 0.05), which corroborates with results reported by El Maadoudi [7] and El Maadoudi and El Housni [8]. The level of hay ingestion considered similar between the three groups reminds us of the result reported by Ephrem et al. [9]. This could be explained by the importance of the nutritional quality of protein sources and the tolerance of sheep to lupine alkaloids. Nevertheless, our results are contradictory to those reported by Lestingi et al. [10,11] by testing the replacement of peas and faba beans. In addition, proteins source did not reveal a significant effect on digestibility of MS, MO, MAT and NDF (P> 0.05). The amount of DCPi was significantly affected (P = 0.0003). Purroy et al [12] did observed significant differences in DM, OM, CP and fiber digestibility’s by replacing soybean meal with lupine seed in lambs. The incorporation of lupine into different quantities improved digestibility’s of DM, OM and cellulose without affecting those of NDF and ADF [13]. Lupine had no significant effect on their average daily gain (ADG). This result agrees with those of many trials carried out on the replacement of protein seeds by lupine which revealed comparable digestive uses between diets [9,11,14,15]. Moreover, Facciolongo et al. [16] found that supplementation with soybean meal and lupine induced similar ADG, while Lestingi et al. [10] showed low weight gain in animals fed lupine diet compared to those which consumed faba beans. We note that although the 3rd group received half of the quantity of lupine consumed by the 2nd one, the corresponding lambs were able to have similar and even better ADG than the others. This leads us to think about the concept of food efficiency. It seems that these animals were able to optimize their efficiency to transform food resources into meat to reach same weight as the others. The nitrogen balance and microbial synthesis are shown in Table 3. It appears that all animals had positive balances. However, a significant variation in the amount of nitrogen intake and retention was observed in the 3rd group in comparison with the two others. This difference is explained by the variation of the ingested quantity of the concentrate. On the other hand, by correcting the retained nitrogen to the nitrogen intake, the nitrogen balance was similar for all diets, which confirms that animals had the same nitrogen use efficiency. Moreover, similar CP digestibility reinforces this finding.

The total amount of purine and the amount of microbial nitrogen were not influenced by the source of supplemented proteins (P> 0.05), which is consistent with the lack of effect on the CP digestibility. In accordance with our results, Yu et al. [17] found no significant differences between purine and microbial nitrogen concentrations in lambs supplemented or not with blue lupine or faba beans.

Table 4 presents the different fermentation parameters. Our study showed that the average pH of rumen juice was affected by the diet (P < 0.05). pH corresponding to the 2nd group (6.25) exceeded significantly that of the 1st group (6.07), but no significant difference was detected between pH corresponding to the 3rd group (6.13) and the others. Brand et al. [18] reported pH values ranged between 6.4 and 6.3 in castrated rams fed a lupine diet. Rumen ammonia level was affected only by diet (P > 0.05). The highest concentration was observed in daily lupine fed lambs (23.9 mg / dl). White et al. (2002) found that ruminal ammonia concentration was higher with lupine incorporation rate of 70% than with 35%, which corroborates the high ammonia level in animals receiving lupine daily and the low one in animals receiving lupine intermittently. Protozoa enumeration revealed a significant difference between diets. Animals belonging to the 2nd group had the highest number (15.3 * 105 / ml) whereas those of the 3rd group had the lowest one (11.7 * 105 / ml). This could be explained by the corresponding ammonia concentrations in the rumen since a large population of protozoa is generally associated with a high concentration of ammonia in the rumen [19,20].

Conclusion

It can be concluded that lupine grains can substitute safely soybean meal in diets of Barbarine lambs. The distribution intermittently of lupine seems to be a double interesting alternative to soybean meal. It decreases lupine quantity and therefore reduce feeding cost

[priya1sharma]

Allantoin Market 2018-2025 | Competitive Analysis by Key Vendors, Growth Factors and Forecast

Allantoin Market 2018-2025 | Competitive Analysis by Key Vendors, Growth Factors and Forecast

December 13, 2018: This report studies Allantoin market, especially in North America, China, Europe, Southeast Asia, Japan and India, with production, revenue, consumption, import and export in these regions, from 2013 to 2018, and forecast to 2025.

This report focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering • Ashland

[rohit0024]

Allantoin Market Growth Analysis, Opportunities, and Forecast by 2022 | Key Industry Participants EMD Performance Materials Corporation, Lubon Industry Co. Ltd.

Allantoin Market Growth Analysis, Opportunities, and Forecast by 2022 | Key Industry Participants EMD Performance Materials Corporation, Lubon Industry Co. Ltd.

The global allantoin market is expected to reach USD 641.7 million by 2022, according to a new report by Grand View Research, Inc. Rising product demand for manufacturing preventive healthcare products owing to its anti-irritant, moisturizing and soothing properties, is expected to drive the market growth over the forecast period.

The industry is expected to witness high growth in cosmetics…