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GMP Grade High Purity Parmaceutical Intermediate API Raw Powder CAS # 83905-01-5 Azithromycin Dihydrate

Azithromycin is a semi-synthetic 15-membered macrolide antibiotic. White or quasi-white crystalline powder; odorless, bitter; slightly damp. This product is soluble in methanol, acetone, chloroform, anhydrous ethanol or dilute hydrochloric acid, and almost insoluble in water.

Basic information: Azithromycin dihydrate 83905-01-5

Product Description

Product Name Azithromycin dihydrate

Synonyms AZITHROMYCIN 2-HYDRATE;1-Oxa-6-azacyclopentadecan-15-one, 13-(2,6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-3,4,6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyloxy-, dihydrate, (2R,3S,4R,5R,8;AZITHROMYCINDIHYDRATE(PATENTED-NOSUPPLY);1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, dihydrate, (2R,3S,4R,5R,8R,10R;1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, dihydrate, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-;azithromycin hydrate;Azithromycin (100 mg);(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one Dihydrate

CAS 83905-01-5

MF C38H72N2O12

MW 748.99

EINECS 1592732-453-0

Product Categories Macrolides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;SELDANE;Inhibitors

applicationFor respiratory infections, urinary tract infections, skin and soft tissue infections and sexually transmitted diseases

Chemical Properties: Azithromycin dihydrate 117772-70-0

Melting point 126 C

Boiling point 717ºC

alpha D26 -41.4° (c = 1 in CHCl3)

refractive index 47 ° (C=2, EtOH)

RTECS RN6960000

Fp >110°(230°F)

storage temp. -20°C Freezer

solubility Soluble in DMSO at 20mg/ml. Also soluble in chloroform or ethylene chloride

Merck 14,915

Spec. Azithromycin dihydrate 117772-70-0

ITEMSSPECIFICATIONSRESULTS

AppearanceA White or almost white crystalline powder Conforms

SolubilityPractically insoluble in water,freely soluble in

anhydrous ethanol and in methylene chloride Conforms

IdentificationIRConforms

HPLC

CrystallinityMeet the requirements Conforms

PH9.0 ~ 11.09.9

Related substancesDesosaminylazithromycin ≤0.3%DL

N-demethylazithromycin ≤0.7%0.001

Any other single impurity ≤1.0%Conforms

Total impurities≤3.0 %0.015

Residual solventsAcetone ≤0.5%0.003

Loss on drying4.0 % ~ 5.0%0.045

Residue on Ignition≤0.3%0.0004

Melting point50 °C ~ 60 °C50 °C ~ 60 °C

Sulphate ash≤0.1%0.0005

Heavy metals≤ 25 ppmNMT25 ppm

Assay

( calculated on the anhydrous basis)945 ug ~ 103 ug of azithromycin per mg982 ug/ mg

ConclusiionThis product complied with the standard of Enterprise/USP

TestsSpecificationResults

DescriptionWhite or almost white powderComplies

SolubilityPractically insoluble in water, freely soluble in ethanol and in methylene chloride.Complies

Identification

A)IR spectrumConforms to azithromycin RSComplies

B)Rt HPLCConforms to azithromycin RSComplies

Specific rotationBetween -45°and -49°-47.6°

CrystallinityMeets the requirementsMeets the requirements

PHBetween 9.0 and 11.010.32

WaterBetween 4.0%and 5.0%4.7%

Residue on ignitionNot more than 0.3%0.08%

Heavy metalsNot more than 25ppmComplies

AssayNot less than 945μg and more than 1030μg of azithromycin(C38H72N2O12) per mg, calculated on the anhydrous basis967μg per mg

MethanolNot more than 0.3%0.031%

EthanolNot more than 0.05%0.0068%

AcetoneNot more than 0.5%0.1475%

ChloroformNot more than 0.006%0.0037%

Function

Temozolomide is used in the treatment of adults with refractory pleomorphic glioblastoma and anaplastic astrocytoma of chemotherapy drugs.

1.Azithromycin Dihydrate is used for acute throat and tonsillitis which are caused by streptococcus pyogenes, otitis media sinusitis acute bronchitis skin soft tissue infection which are caused by sensitive bacteria.

2.Azithromycin Dihydrate is also used for pneumonia urethritis cervicitis and so on.

Suitable for sensitive caused by the bacterium respiratory tract, skin soft tissue infection caused by the original body of garment of sexually transmitted diseases. For influenzae, pneumococci and mo draw CARDS he caused by bacteria etc of acute brochitis, chronic obstructive pulmonary disease amalgamative infection, pneumonic wait for the efficient above 90%, bacterial remoal reach 85%. For pyogenes, aureaus etc caused furuncle swollen, cellulitis wait, use this product daily 1 times 5 therapy (1.5 g), total cure for 53% ~ 74%, efficient 90%, its curative effect and the benzene thiazole Westwood, erythromycin and cephalosporins ampicillin similar. Single-agent 1g treatment for chlamydial infection, its curative effect with ciprofloxacin or doxycycline grain phase.

Packing

1. Client is first. We are trying to bring maximum profit to our clients and we only share small.

2. Credibility is the most important.

3. Quality control is our life.

4. Great sense of responsibility.

5. We will be responsible for not only our products, our clients, our suppliers, also the society

FAQ

Q1:Can I get a sample?

A:Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

Q2:What's the MOQ?

A: For the high value product, our MOQ starts from 1g and generally starts from 10g.

For other low value product, our MOQ starts from 100g and 1kg.

Q3:Is there any discount?

A:Yes, different quantity has different discount.

Q4: How to confirm the Product Quality before placing orders?

A: By sending you our available free samples.Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.

Q5:What's your lead time?

A:We can arrange the shipment in 3 working days after receiving your payment, except the customised products.

introduce

1.Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infection, strep throat , pneumonia, typhoid, and sinusitis

2.It has used primarily to prevent bacterial infections in infants and those with weaker immune system

3.It is also effective aganinst certain sexually transmitted infections , such as non-gonococcal urethritis, chlamydia and cervicitis

4.Azithromycin cin is use for acute pharyngitis , acute tonsillitis caused by Streptococcus pyogenes

5.Azithromycin is used for acute throat and tonsilitis which are caused by streptococcus pyogenes , otitis

6.Azithromycin can treatment of mrdia sinusitis acute bronchitis skin soft tissue infection which are caused by sensitive bacteria

7.Azithromycin is also used for pneumonia urethritis cervicitis and so on.

Company Profile

Arshine Group is composed of 5 subsidiaries, including Arshine Pharmaceutical Co.,Ltd, Arshine Food Additive Co., Ltd, Arshine Animal Healthcare Co., Ltd, Arshine Life Science Co., Ltd and Hangzhou Arshine Branch. Arshine specializes in exporting human and veterinary API, vitamins, amino acids, minerals, food and feed additives and plant extracts etc. Arshine has exported around 2000 products to 90 countries and areas in Europe, Middle East, East Asia and South Asia. Since establishment, Arshine’s annual sales volume has increased from USD 1 million to USD 100 million, growing hundredfold in 10 years. Having established long-term cooperation with more than 800 manufacturers, Arshine is regional sales representative or even exclusive agent for many manufacturers nowadays. To our pride, Arshine ranks among top 10 in all pharmaceutical raw materials export enterprises in China, top 3 in the private exporters.

After-sale Service : Sales: 24hours to reply your E-mail Market information trend share with customers Suggestion for purchase decision Financial: Different payment terms: TT, LC, DP and so on Sino-Sure credit application and market risk control Shipment conditions: Update the whole process from China to destination 10 days by air & 14 days by sea to finish usually Fast custom clearance at destination Doc after shipment date: Same day for air shipment and LCL sea shipment 3 working days for FCL sea shipment 100% clear and perfect docs Reputation: Implementing contract terms strictly Timely solve any discrepancy or goods claims Take our responsibility for loss if it is our liability Others: Assistant: sample working; help you solve the problem in China with others Registration: pr

More details：http://arshine.lookchem.com/

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#Azithromycin dihydrate

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