#8 Dimethyl 5 Phenyl

[midseo]

Safranine 0, Safranine Basic Red 2, Manufacturer, Exporter, India

Safranine 0, Safranine Basic Red 2, Safranines, Manufacturers, Supplier, Exporter, Mumbai, India.

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[mitivy]

CAS NO.93-90-3 2-(N-Methylanilino)ethanol Manufacturer/High quality/Best price/In stock

Quick Details   CAS No. 93-90-3 Other Names n-(2-hydroxyethyl)-n-methylaniline MF c9h13no EINECS No. 204-493-5 Place of Origin xuzhou, China Type Pharmaceutical Intermediates, n,n-dimethylaniline Purity 99% Brand Name crovell Model Number n,n-dimethylaniline Application raw materials Appearance light yellow liquid Product Name n,n-dimethylaniline MOQ 0.1 Kg Color Light yellow liquid Shelf Life 2 Years Packing at your requested Assay 99%minn Supply Ability 100 Kilogram/Kilograms per Month   Superiority： 1.High quality with competitive price: We are manufacturer and can provide high quality products with factory price. 2.Fast and safe delivery ① Parcels can be sent out within 48 hours after payment. Tracking number is available. ②Secure and discreet shipment. You have various choices of transportation methods. 3.We have clients throughout the world. ① Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire. ②Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility. ③High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. Company Information MIT-IVY INDUSTRY CO.,LTD is a manufacturer and exporter of fine chemical dyes & pharmaceutical intermediates in China. Mainly produce aniline series products and chlorine series products. We are a young company full of vitality and vitality. The company has a group of energetic, well-trained employees and strong technical research and development capabilities. We specialize in the production, development and sales of API intermediates, fine chemicals and plant extracts. Relying on advanced equipment and strict management, adhere to the business philosophy of "openness, tolerance, innovation, and sharing" to create a win-win cooperationplatform.Everything comes from innovation, it is our philosophy ! If you are interested in getting more quotations, please add WHATSAPP:0086-13805212761 or E-MAIL:info@mit-ivy.com MIT-IVYINDUSTRYCO.,LTDMit-Ivy is a well-known fine chemicals and pharmaceutical intermediates manufacturer with strong R&D support in China. Mainly involved Aniline, Chlorine products. Payment：DA 60 DAYS TEL:008619961957599   E-MAIL:info@mit-ivy.com 产品 Product CAS N,N-二甲基-1,4-苯二胺 N,N-Dimethyl-1,4-phenylenediamineDMPD 99-98-9 N,N-二甲基苄胺 N,N-Dimethylbenzylamine  BDMA 103-83-3 N,N-二甲基甲酰胺   N,N-Dimethylformamide  DMF .68-12-2 N,N-二甲基甲酰胺二甲缩醛 DMF-DMA N,N-Dimethylformamidedimethyl acetal  (DMF-DMA) 4637-24-5 N,N-二甲基乙酰胺 N,N-Dimethylacetamide   DMAC 127-19-5 N,N-二乙基间甲苯甲酰胺 避蚊胺 N,N-diethyl-m-toluamide    DEET 134-62-3 N,N-二乙基羟胺 N,N-Diethylhydroxylamine  DEHA 3710-84-7 N-甲基-N-羟乙基苯胺 2-(N-甲基苯胺)乙醇 2-(N-methylanilino)ethanol 93-90-3 N-甲基吡咯烷酮 N-methylpyrrolidone 872-50-4 N,N-二甲基苯胺 N,N-Dimethylaniline   DMA 121-69-7 N,N-二甲基对甲苯胺 N,N-Dimethyl-p-toluidine  DMPT 99-97-8 N,N-二甲基邻甲苯胺 N,N-Dimethyl-o-toluidine   DMOT 609-72-3 N,N-二乙基苯胺 N,N-Diethylaniline 91-66-7 N,N-二乙基间甲苯胺 N,N-Diethyl-m-toluidine 91-67-8 N,N-二羟乙基苯胺 N,N-Dihydroxyethylaniline   PDEA 120-07-0 N-乙基间甲苯胺 N-乙基-3-甲基苯胺 N-Ethyl-m-toluidine 102-27-2 N-乙基-N-氰乙基苯胺 3-(N-ethylanilino)propiononitrile 148-87-8 N-乙基-N-羟乙基苯胺 N-Ethyl-N-hydroxyethylaniline 92-50-2 N-乙基-N-苄基苯胺 乙基苄基苯胺; N-苄基-N-乙基苯胺 N-ethyl-N-phenylbenzenemethanamine 92-59-1 N-乙基-N-氰乙基间甲苯胺 N-2-cyanoethyl-N-ethyl-m-toluidine 148-69-6 N-乙基-N-苄基间甲苯胺 N-Benzyl-N-ethyl-m-toluidine 119-94-8 N-乙基邻甲苯胺 N-Ethyl-o-toluidine 94-68-8 N-乙基苯胺 N-Ethylaniline 103-69-5 N-甲基苯胺 N-Methylaniline 100-61-8 N,N-二甲基-间甲基苯胺 N,N-DIMETHYL-M-TOLUIDINE 121-72-2 N-甲基二苯胺 N-Methyldiphenylamine 552-82-9 N-甲基-邻甲基苯胺 N-METHYL-O-TOLUIDINE 611-21-2 N-甲基-对甲基苯胺 N-METHYL-P-TOLUIDINE 623-08-5 4-甲基-N-苯基苯胺 N-PHENYL-P-TOLUIDINE 620-84-8 N-异丙基苯胺 N-ISOPROPYLANILINE 768-52-5 N,N-二氰乙基苯胺 N,N-Dicyanoethylaniline 1555-66-4 N,N-二羟乙基-对甲基苯胺 N,N-DIHYDROXYETHYL-P-TOLUIDINEDHEPT .3077-12-1 N-乙基-2-硝基苯胺 N-Ethyl-2-Nitro-Benzenamine 10112-15-9 2,4-二氯苯胺 2,4Dichloroaniline 554-00-7 N-(2-羟乙基)乙二胺 AEEA 111-41-1 1,3-二甲基-2-咪唑啉酮N,N-二甲基亚乙基脲1,3-二甲基-2-咪唑啉酮（DMI) 1,3-Dimethyl-2-imidazolidinone  DMI N,N'-dimethylimidazolidinone 80-73-9 N,N-二苄基羟胺 N,N-Dibenzylhydroxylamine 621-07-8 对甲苯胺 P-Toluidine  PT 106-49-0 邻甲苯胺 O-Toluidine  OT 95-53-4 二乙基乙醇胺 DEEA;DEAE 100-37-8 甲萘胺 AlphaNaphthylamine 134-32-7 间二氯苯 1,3-Dichlorobenzene   MDCB 541-73-1 间甲苯胺 M-Toluidine  MT 108-44-1 间苯二胺 M-PHENYLENEDIAMINE  MPDA 108-45-2 多乙烯多胺 PEPA 68131-73-7 二乙烯三胺(DETA) Diethylenetriamine  DETA 111-40-0 三乙烯二胺 Triethylenediamine 280-57-9 三乙烯四胺 TriethylenetetramineTETA 112-24-3 四乙烯五胺 TEPA 112-57-2 Read the full article

[jonesmoker]

N-isopropylbenzylamine crystal cas 102-97-6 with large stock and low price

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Anhui Moker New Material Technology Co.,ltd is an enterprise whose all staffs are engrossed with professional production of chemical product, the selling of pharmaceutical intermediate and the other chemical products. Also we have the  self-support import and export entitlements. Our main products include the pharmaceutical intermediate,food additives, pigment, medical grade, industrial grade, food grade and household chemicals and so on.Our products have been exported to more than 30 countries in the world. At the same time , we have a professional scientific team and advanced devices ,and we strive for sticking to opaque principle. What we want to do is to devote ourselves in providing the customer with an  effective and qualified service. We have been sticking to the rule of quality first, service paramount and we are establishing reciprocal business relationship with customers all over the world.

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[sinosil]

Chloro Silanes

SiSiB SILICONES is a leading manufacturer of organosilanes for over 30 years. SiSiB chlorosilanes are a group of reactive, chlorine-containing silicon compounds.

 SiSiB is a worldwide leading manufacturer of organosilanes for over 30 years. SiSiB chlorosilanes are a group of reactive, chlorine-containing silicon compounds. Each such compound has at least one silicon-chlorine bond. Usually chlorosilanes are intermediates used to produce siloxanes and silanes, also used as protecting agent for intermediates in pharmaceutical syntheses. Most of chlorosilanes are clear liquids that react with water to form corrosive and toxic hydrogen chloride gas and hydrochloric acid.

 Methyl chlorosilanes have one to three methyl groups, such as Dimethylchlorosilane M2, Trimethylchlorosilane M3, Methyltrichlorosilane M1, are basic material to synthesis various silicone substances. They are directly synthesized by silicon powder and methyl chloride gas under the effect of catalyst. SiSiB also provides propyl chlorosilanes, vinyl chlorosilanes and phenyl chlorosilanes. Typical products include SiSiB® PC5930 (Propyltrichlorosilane), SiSiB® PC6100 (Vinyltrichlorosilane), SiSiB® PC6300 (Vinylmethyldichlorosilane), SiSiB® PC8130 (Phenyltrichlorosilane), SiSiB® PC8220 (Diphenyldichlorosilane) and SiSiB® PC8310 (Triphenylchlorosilane).

 Chloro silanes undergo hydrolysis gives short-chain polymers and polycondensation under catalysts obtains and chain terminators produces required molecular weight of final products, such as silicone oils, silicone gums and silicone resins.

 Chlorosilane may release toxic and/or flammable gases upon reacting vigorously with bases and organic/inorganic acids. Chlorosilane even react with water/moist air/steam to give heat, toxic and corrosive hydrogen chloride, maybe also flammable hydrogen gases. To ensure the safety of transportation, packing with good tightness is necessary.

 SiSiB® PC5620 (Triethychlorosilane), SiSiB® PC5710 (tert-Butyldimethylchlorosilane), SiSiB® PC8710 (tert-Butyldiphenylchlorosilane) are typical silane protective agents, which can protect or deprotect functional groups selectively. They are widely used in the syntheses of pharmaceutical intermediates.

 Chloro Silanes Recommendations

 SiSiB® PC5010

High purity 3-Chloropropyltrichlorosilane, CAS No. 2550-06-3. It is used as an intermediate for other functional organosilanes. Equivalent of Dow's Z-6010.

 SiSiB® PC5020

High purity Chloropropylmethyldichlorosilane, CAS No. 7787-93-1. It is used as an intermediate for other functional organosilanes.

 SiSiB® PC5130

High purity Methyltrichlorosilane, CAS No. 75-79-6. It is used for production of silane crosslinkers, silane coupling agents, and siloxanes; Hydrophobic treatment; Pyrolysis to form Si-C coatings.

 SiSiB® PC5210

High purity Dimethylchlorosilane, CAS No. 1066-35-9. Organic chlorosilanes are usually used as coatings for silicon and glass surfaces, and in the production of silicone (polysiloxane) polymers.

 SiSiB® PC5220

High purity Dimethyldichlorosilane, CAS No. 75-78-5. Useful in the synthesis of silanes and siloxanes. Equivalent of Dow's Z-1219, ShinEtsu's KA22.

 SiSiB® PC5310

High purity Trimethylchlorosilane, CAS No. 75-77-4. It is used to prepare silicone polymers.Equivalent of Dow's Z-1224, Wacker's Silan-M3, ShinEtsu's KA31.

 SiSiB® PC5540

High purity Chloromethyl-dimethyl-chlorosilane, CAS No. 1719-57-9. It is an important intermediate for Alfa-series silane coupling agents and used for synthesis of pesticides. Equivalent of Wacker's CMM2.

 SiSiB® PC5620

High purity Triethylchlorosilane, CAS No. 994-30-9. It is used as a surface modifier for Potassium Titanate Whiskers. Equivalent of Wacker's SILANE E3, Evonik's Dynasylan TECS.

 SiSiB® PC5710

Silane Blocking Agent. High purity Tert-butyldimethylchlorosilane, CAS No. 18162-48-6. It may be used as silylating agent for derivatization of alcohols, ketones, carboxylic acids, amines, amides and mercaptanes selectively into functional groups in different sterical environments. Equivalent of Dow's TBMS, Wacker's TBM2.

 SiSiB® PC5880

High purity Octodecyltrichlorosilane, CAS No. 112-04-9. It is used as a surface modifier for Potassium Titanate Whiskers.

 SiSiB® PC5930

High purity Propyltrichlorosilane, CAS No. 141-57-1. It is used as raw material for Propyltrimethoxysilane, Propyltriethoxysilane, and Propyltriacetoxysilane etc.

 SiSiB® PC5936

SiSiB® PC5936 is colorless clear liquid.

 SiSiB® PC6100

High purity Vinyltrichlorosilane, CAS No. 75-94-5. It is used as raw material for Vinyltrimethoxysilane, Vinyltriethoxysilane etc. Equivalent of Dow's Z-2380, Evonik's Dynasylan VTC, ShinEtsu's KA1003.

 SiSiB® PC6200

High purity Vinyldimethylchlorosilane, CAS No. 1719-58-0. It is used as a monomer in the production of silicone polymers or silicone resins.

 SiSiB® PC6300

High purity Vinylmethyldichlorosilane, CAS No. 124-70-9. It is a chlorosilane intermediate for siloxane manufacture.

 SiSiB® PC8130

High purity Phenyltrichlorosilane, CAS No. 98-13-5. Synthesis of silanes and silicones hydrophobic treatment. Equivalent of Dow's Z-1216, ShinEtsu's KA103.

 SiSiB® PC8220

High purity Diphenyldichlorosilane, CAS No. 80-10-4. It is used as other silanes and siloxanes intermediates. Equivalent of Dow's Z-1223, ShinEtsu's KA202.

 SiSiB® PC8310

High purity Triphenylchlorosilane, CAS No. 76-86-8 / 155684-37-0. It is used for synthesis of pharmaceutical intermediates.

 SiSiB® PC8610

High purity Phenylmethyldichlorosilane, CAS No. 149-74-6. It is used as other silanes and siloxanes intermediates. Equivalent of Dow's Z-1221, Wacker's SILANE PM.

 SiSiB® PC8710

Silane Blocking Agent. High purity Tert-butyldiphenylchlorosilane, CAS No. 58479-61-1. It may be used as silylating agent for derivatization of alcohols, ketones, carboxylic acids, amines, amides and mercaptanes selectively into functional groups in different sterical environments. Equivalent of Wacker's SILANE TBP2.

 SiSiB® PC9710

High purity 3,3,3-Trifluoropropyl-methyl-dichlorosilane, CAS No. 675-62-7. It is the intermediate for manufacturing of D3F, 1,3,5-tris(trifluoropropyl) trimethyl cyclotrisiloxane.

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[phenacetinpowder]

E-mail:amy@whmulei.com Wuhan Mulei New Material Technology Co. Ltd Website:www.whmulei.com

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[omc-juniperpublishers]

Simultaneous Estimation of Aliskiren and Amlodipine in Combined Tablet Formulation by Simultaneous Equation and First Derivative Spectroscopic Methods-JuniperPublishers

Journal of Chemistry-JuniperPublishers

                                      Abstract

Simple, sensitive and accurate UV-spectroscopic methods were developed and validated for simultaneous estimation of aliskiren and amlodipine in tablet formulation using simultaneous equation and first derivative spectroscopic methods. Developed methods include direct estimation of amlodipine at 365nm without any interference, since aliskiren has zero absorbance at this wavelength. Estimation of aliskiren through simultaneous equation was performed at 279 nm, while 236.8 nm were selected as zero crossing point for estimation of aliskiren by first order derivative spectroscopic method. Linearity was found to be satisfactory over the concentration range of 25-300μg/ml and 5-100μg/ml for aliskiren and amlodipine respectively. The mean percentage label claim of aliskiren and amlodipine using simultaneous equation was 99.84 and 99.85 % respectively, while for first derivative spectroscopic method it was found to be 100.36 and 99.85% respectively. The developed methods are economical and reproducible for routine analysis of aliskiren and amlodipine in tablet formulation.

Keywords: Aliskiren; Amlodipine; First order derivative method; Simultaneous equation Method; Validation

Go to

Introduction

Chemically aliskiren (ALS) is (2S, 4S, 5S, 7S)-5-Amino-N-(3- amino-2, 2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy- 3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2- ylnonanamide [1]. It is a is a white to slightly yellowish crystalline powder. Aliskiren is the first in a class of drugs called direct renin inhibitors. It is used for essential (primary) hypertension [2]. It is highly soluble in water, ethanol and DMSO [3,4]. Amlodipine (AML) is chemically 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy) methyl]-4-(2- chlorophenyl)-1, 4-dihydro-6-methyl-3,5- pyridinedicarboxylate. Amlodipine besylate is white to off white powder, crystalline and has long-acting 1, 4-dihydropyridine calcium channel blocker [5,6]. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Amlodipine is used to treat hypertension and chronic stable angina [7,8]. Several analytical methods have been reported for estimation of ALS and its combination with other drugs which includes spectrophotometry and HPLC [9-13]. Similarly, various spectrophotometric and HPLC methods have been reported for estimation of AML and its combination with other drugs [14-18]. In the present work, a successful attempt has been made to estimate both these drugs simultaneously using dual wavelength UV spectrophotometric method. Structures of both the drugs ALS and AML are given in (Figures 1 & 2).

Go to

Materials and Methods

Instrumentation

A double beam UV spectrophotometer (UV-1800, Shimadzu, Japan) with UV probe software version (2.31) and 10mm quartz cells was used. All weights

Reagents and Chemicals

Pure drug, Aliskiren hemifumarate and amlodipine besylate was procured from Swapnroop Drugs and Pharmaceuticals, Aurangabad, Maharashtra, India. Marketed formulation was procured from local Pharmacy. All the chemicals and reagents used were of A.R. grade.

Method Development

Preparation of Standard Stock Solution: The standard stock solutions of Aliskiren and Amlodipine were prepared by dissolving 110.5mg of aliskiren hemifumarate (110.5mg of aliskiren hemifumarate is equivalent to 100mg of aliskiren) and by dissolving pure drug of amlodipine besylate equivalent to 100mg of amlodipine in separate 100 mL volumetric flask containing sufficient quantity of distilled water, the solutions were sonicated for 5 min then volume was made up to the mark with distilled water to get a concentration of 1000μg/mL of each solution. The standard stock solutions were further diluted to obtain desired concentrations.

Preparation of Sample Solution: Twenty tablets were weighed and powdered. The quantity of the powder equivalent to 150mg of ALS was transferred to 100 ml volumetric flask. The content was mixed with sufficient quantity of distilled water and sonicated for 20min to dissolve the drug. The solution was then filtered through a Whatman filter paper no. 41 and made up to the mark with distilled water An aliquot of solution (1.0ml) was transferred to a 10 ml volumetric flask and the volume was adjusted up to the mark with distilled water to obtain required concentration of ALS (150μg/ml) and AML (10μg/ml).

Simultaneous Equation Method

For simultaneous estimation of ALS and AML using simultaneous equation method (SE method) the solutions of ALS (50μg/ml) and AML (20μg/ml) were prepared from the standard stock solutions of ALS and AML and scanned over the range of 200 nm to 400 nm. An overlain spectrum was studied for development of suitable method for analysis. The overlain spectrum of ALS and AML is shown in (Figure 3). From the overlay spectra, 279 nm wave length was selected for the estimation of ALS using simultaneous equation method. Estimation of AML was done as a single component at 365nm. The absorptivity values were calculated and were applied in framed simultaneous equation 1, which is presented as,]

Where, A is absorbance of sample solution at 279 nm, CX and CY are concentrations of ALS and AML, respectively in μg/ml.

First Order Derivative Method

Estimation of AML was performed similarly as in simultaneous equation method. For estimation of ALS first order derivative method (DR method) was applied. The zero order spectrum was then derivatised to obtain first order derivative spectrum (Figure 4). From this spectrum of ALS and AML zero crossing point of 236.8 nm was selected using 2 nm as wavelength interval (Δλ = 2) and scaling factor taken as 1 for estimation of ALS.

Analysis of ALS & AML in Tablet Formulation

The absorbance of final sample solution was measured against distilled water as blank at 279 nm for SE method and at 236.8nm for DR method while the estimation of AML was done directly at 365nm. The analysis procedure was repeated five times for marketed formulation.

Method Validation

Linearity and Range: Aliquots of standard solution of ALS (0.25, 0.5, 0.75, 1.0, 1.25, 1.5, 2.0 and 3.0 ml) and AML (0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6 and 1.0 mL) were transferred in a series of 10 ml volumetric flasks. The volume was adjusted up to the mark with distilled water and mixed. Absorbance values were recorded at 279 nm for SE method and at 236.8 nm for DR method against distilled water as blank for determination of ALS. Absorbance values of AML were recorded at 365 nm for all dilutions. The calibration curves were plotted between the concentration of component and absorbance values of ALS for SE method and between concentration and dA/dX for DR method. Calibration curve for AML was plotted between the concentration of component and absorbance value of AML.

Standardization of the Method by Analysis of Mixed Standard Solutions: To check the validity of the selected methods, mixed standard solutions of ALS and AML were prepared. The solutions were subjected to determine absorbance values at respective wavelengths and concentration of the components were calculated.

Accuracy: The accuracy of the method was determined for both the methods by calculating recoveries of ALS and AML by the standard addition method. Known amount of standard solution of ALS and AML were added at 80%, 100% and 120% levels to pre-quantified tablet sample solutions of ALS and AML. The results are reported in terms of % Recovery

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Results and Discussion

Method Development and Validation

Two simple, sensitive and accurate UV-spectroscopic methods were developed and validated for simultaneous estimation of aliskiren and amlodipine in tablet formulation using SE and DR spectroscopic methods. From the overlain spectra of the drugs it was observed that SE and DR spectroscopic methods were suitable methods for simultaneous determination of ALS and AML. Distilled water was taken as solvent system, as both the drugs were soluble in this solvent and reduce the cost of the method. In SE method and DR method, wavelengths 279 nm and 236.8 nm respectively were selected for determination of ALS, whereas AML was estimated directly at 365 nm as ALS has zero absorbance at this wavelength. Optimized method parameters for simultaneous equation and first order derivative spectroscopic methods are shown in Table 1.

Linearity

The calibration curves of ALS and AML were linear in the range of 25-300μg/ml and 5-100μg/ml respectively. Regression equation and R2 values are given in (Table 1).

Standardization of the method by analysis of mixed standard solutions

The concentration of ALS and AML recovered from mixed standard solutions for both methods was within range and are given in Table 2.

Accuracy

The percentage recoveries of drugs from sample were determined by standard addition of pure drugs at three known concentrations and recoveries were obtained at each level.The percent recoveries for ALS were found to be in the range of 100.26- 100.40% for SE method and 99.94-100.45 % for DR method. Percent recoveries for AML were found to be in the range of 99.62-100.13% for both methods. The results of accuracy studies are shown in Table 3.

Application of the Method in Assay of Tablets

The proposed UV method was applied for the determination of ALS and AML in their combined pharmaceutical formulation and the results are shown in Table 4.

*Mean ± SD (n=3), SD (Standard deviation), %RSD (Percent relative standard deviation).

*Mean ± SD (n=5), SD (Standard deviation), %RSD (Percent relative standard deviation).

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Conclusion

The proposed simultaneous equation method and first order derivative gives accurate and precise results for determination of aliskiren and amlodipine in marketed formulation (tablet) without prior separation and is easily applied for routine analysis. Method validation has been demonstrated by variety of tests like linearity, accuracy and validation through mixed standard. The proposed method can be successfully applied for determination of these drugs in commercial tablet formulation.

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Acknowledgement

The authors express their sincere gratitude to Swapnroop Drugs and Pharmaceuticals, Aurangabad, Maharashtra, India for providing the pure drug samples of Aliskiren Hemifumarate and Amlodipine Besylate and are also thankful to colleagues and authorities of Department of Pharmacy, SRMSCET, Bareilly, U.P. who helped us in this work.

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Payment：DA 60 DAYS TEL:008619961957599   E-MAIL:info@mit-ivy.com 产品 Product CAS   N-甲基间甲苯胺 N-Methyl-M-Methylaniline 696-44-6 N-羟乙基苯胺 N-(2-hydroxyethyl)-Aniline 122-98-5 N-乙基对甲苯胺 N-ethyl-p-toluidine 622-57-1 N,N-二甲基邻甲苯胺 N,N-Dimethyl-o-toluidine 609-72-3 N-甲基邻甲苯胺 N-Methyl-o-methylaniline 611-21-2 N,N-二乙基对甲苯胺 N,N-Diethyl-p-toluidine 613-48-9 N,N-二乙基间甲苯胺 N,N-diethyl-m-toluidine 91-67-8 N-氰乙基－N-羟乙基间甲苯胺 N-cyanoethyl-n-hydroxyethyl-m-toluidine 119-95-9 N-乙基间甲苯胺 N-ethyl-m-toluidine 102-27-2 N-氰乙基－N-羟乙基苯胺 N-cyanoethyl-n-hydroxyethyl aniline 92-64-8 N-乙基邻甲苯胺 N-ethyl-o-toluidine 94-68-8   N,N-二羟乙基对甲苯胺 N,N-dihydroxyethyl-p-toluidine   .3077-12-1   N,N-二乙基苯胺 N,N-diethyl aniline 91-66-7 N-丁基－N-羟乙基苯胺 N-butyl-n-hydroxy aniline 3046-94-4 N-乙基－N-氰乙基间甲苯胺 N-ethyl-n-cyanoethyl-m-toluidine 148-69-6 N-丁基－N-氰乙基苯胺 N-butyl-n-cyano aniline   61852-40-2 N-甲基－ N-羟乙基苯胺 N-methyl-n-hydroxyetjyl aniline   93-90-3 N,N-二丁基苯胺 N,N-dibutyl aniline 613-29-6 N-乙基－N-氰乙基苯胺 N-ethyl-n-cyanoethyl aniline   148-87-8 N-正丁基苯胺 N-Phenyl-N-butyl aniline 1126-78-9   N-乙基－N-羟乙基苯胺 N-ethyl-n-hydroxyethyl aniline 92-50-2 N-乙基－N-苄基间甲苯胺 N-ethyl-n-benzyl-m-toluidine 119-94-8 N-甲基－N-苄基苯胺 N-methyl-n-benzyl aniline 614-30-2 N-异丙基苯胺 N-isopropy aniline   768-52-5   N-乙基－N-苄基苯胺 N-ethyl-n-benzyl aniline 92-59-1 N-环已基苯胺 N-Cyclohexylaniline 1821-36-9   N,N-二甲基间甲苯胺 N,N,3-trimethyl- Dimethyl-m-toluidine   121-72-2   N-甲基甲酰苯胺 N-Methylformanilide 93-61-8   N-甲基-N-羟乙基对甲苯胺 N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE 2842-44-6 N,N-二甲基对甲苯胺 N,N,4-trimethyl-;dimethyl-4-toluidine; Dimethyl-p-toluidine 99-97-8   N-甲基对甲苯胺 N-Methyl-p-toluidine   623-08-5 N,N-二甲基苯胺 N,N-dimethyl aniline 121-69-7 N,N-二羟乙基苯胺 N,N-dihydroxyethyl aniline 120-07-0 N-乙基-N-羟乙基间甲苯胺 N-Ethyl-N-Hydroxyethyl-M-Toluidine 91-88-3   N,N-二羟乙基间甲苯胺 N,N-dihydroxyethyl-m-toluidine   91-99-6   N-乙基苯胺 N-ethyl aniline 103-69-5   N-甲基苯胺 N-methyl aniline 100-61-8 N-甲基对甲苯胺 4-Methyl-N-methylaniline 623-08-5 N-甲基-N-羟乙基苯胺   2-(N-Methylanilino)ethanol 93-90-3 N,N-二甲基对苯二胺 N,N-DIMETHYL-P-PHENYLENEDIAMINE 99-98-9 3-(甲氨基)甲苯 3-(Methylamino)toluene 696-44-6 N,N-二异丙醇对甲苯胺 DIPROPOXY-P-TOLUIDINE 38668-48-3 N,N-二乙基邻甲苯胺 N,N-DIETHYL-O-TOLUIDINE 606-46-2 N-甲基对硝基苯胺 N-Methyl-4-nitroaniline 100-15-2 N,N-二苄基苯胺 N,N-DIBENZYLANILINE 91-73-6 N-苯基乙醇胺 2-Anilinoethanol 122-98-5 N-苄基苯胺 N-Phenylbenzylamine 103-32-2 N-羟乙基间甲苯胺 N-2-HYDROXYETHYL-M-TOLUIDINE 102-41-0 N-乙基N氯乙基间甲苯胺 N-ETHYL-N-CHLOROETHYL-M-TOLUIDINE 22564-43-8   N,N-二乙基-4-氨基-2-甲基苯甲醛 4-Diethylamino-2-methylbenzaldehyde 92-14-8 间甲苯胺 M-Toluidine  MT 108-44-1 1,4-二溴-2,5-二碘苯 1,4-DIBROMO-2,5-DIIODOBENZENE 63262-06-6 N,N-二羟乙基对苯二胺硫酸盐 N,N-Bis(2-hydroxyethyl)-p-phenylenediamine sulphate 54381-16-7 N-乙基-N-苄基-4-氨基苯甲醛 4-(N-Ethyl-N-benzyl)amino-benzoaldehyde 67676-47-5 N,N-二乙基-4-氨基苯甲醛 4-Diethylaminobenzaldehyde 120-21-8 对二甲胺基苯甲醛 p-Dimethylaminobenzaldehyde 100-10-7 2-氨基噻唑 2-Aminothiazole 96-50-4 对甲苯胺 P-Toluidine  PT 106-49-0 N,N-双(2-羟基丙基)苯胺 N,N-BIS(2-HYDROXYPROPYL)ANILINE 3077-13-2 N-乙基-N-氰乙基苯胺 3-Ethylanilinopropiononitrile 148-87-8 N-乙基-N-(3'-磺酸苄基)苯胺 N-Ethyl-N-benzylaniline-3'-sulfonic acid 101-11-1 邻苯甲酰苯甲酸甲酯 Methyl 2-benzoylbenzoate 606-28-0 对羟基苯甲酸甲酯 Methylparaben 99-76-3 十四酸异丙酯 Isopropyl myristate 110-27-0 棕榈酸异丙酯 Isopropyl palmitate 142-91-6 邻甲苯胺 O-Toluidine  OT 95-53-4 4-甲基-N-苯基苯胺 N-PHENYL-P-TOLUIDINE 620-84-8 N,N-二甲基苄胺 N,N-Dimethylbenzylamine  BDMA 103-83-3 N,N-二甲基甲酰胺   N,N-Dimethylformamide  DMF .68-12-2 N-甲基甲酰胺 N,N-Dimethylformamidedimethyl acetal  (DMF-DMA) 4637-24-5 N,N-二甲基乙酰胺 N,N-Dimethylacetamide   DMAC 127-19-5 N,N-二乙基间甲苯甲酰胺 避蚊胺 N,N-diethyl-m-toluamide    DEET 134-62-3 N,N-二乙基羟胺 N,N-Diethylhydroxylamine  DEHA 3710-84-7 N,N-二甲基-间甲基苯胺 N,N-DIMETHYL-M-TOLUIDINE 121-72-2 N-甲基二苯胺 N-Methyldiphenylamine 552-82-9 N,N-二氰乙基苯胺 N,N-Dicyanoethylaniline 1555-66-4 N-乙基-2-硝基苯胺 N-Ethyl-2-Nitro-Benzenamine 10112-15-9 N-(2-羟乙基)乙二胺 AEEA 111-41-1 二乙烯三胺(DETA) Diethylenetriamine  DETA 111-40-0 三乙烯二胺 Triethylenediamine 280-57-9 三乙烯四胺 TriethylenetetramineTETA 112-24-3 四乙烯五胺 TEPA 112-57-2 间二氯苯 1,3-Dichlorobenzene   MDCB 541-73-1 间二三氟甲苯 1,3-Bis(trifluoromethyl)-benzene 402-31-3 粉末丁��橡胶 MITIVY33-1（POLYMER/ADHESIVE COMPOUNDING） 9003-18-3 十六烷基氯化吡啶 Cetylpyridinium chloride monohydrate 6004-24-6 对氯甲苯 4-Chlorotoluene 106-43-4 无水硫酸钠 SODIUM SULFATE 15124-09-1 碱性嫩黄 Auramine O 2465-27-2 偶氮二异丁腈 2,2'-Azobis(2-methylpropionitrile) 78-67-1 Read the full article

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Validation of Assay for Simultaneous Estimation of Ebastine and Montelukast in Tablet Dosage Forms by RP-HPLC Method

INTRODUCTION Ebastine is a second-generation H1 receptor antagonist that is indicated mainly for allergic rhinitis and chronic idiopathic urticaria. It is chemically known as 1-(4-tert-butylphenyl)-4- butan-1-one. Figure 1. It is soluble in methanol, chloroform, and dimethyl sulfoxide. Ebastine and its active metabolite is selective peripheral histamine H1 receptor antagonist. Thus it prevents the attachment of histamine on receptors and its activation (Activation of receptors of histamine on various tissues produce various allergic symptoms e.g. a Runny nose). Ebastine also has a specific inhibitory effect on Th2-type cytokine production and inhibit T cell migration and pro-inflammatory cytokine production by T cells and macrophages. Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.  It is chemically known as Sodium; 2- phenyl]-3- propyl] sulfanylmethyl] cyclopropyl] acetate. Figure 2. It is freely soluble in ethanol, methanol, and water. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation. A detailed survey of the literature for Ebastine and Montelukast reveals that the available analytical methods are costly and with more retention time. Hence we developed a rapid and sensitive RP-HPLC method with UV detection (244 nm) for routine analysis of montelukast sodium and ebastine in a pharmaceutical formulation (Ebast-M). A literature review revealed few methods on method development and validation of Ebastine and Montelukast by RP-HPLC. So now the main aim is to develop a method with less run time and retention time compared to those methods.1-7 MATERIAL AND METHOD Instruments HPLC from Waters with model No HPLC 2965 system with Empower 2 software. Materials Ebastine and Montelukast (API)  were received from spectrum lab, Combination Ebastine and Montelukast (EBAST M TABLET) tablets were obtained from Micro Labs, Distilled water (HPLC grade), acetonitrile, ammonium acetate buffer, methanol, Potassium dihydrogen phosphate buffer, Triethylamine, orthophosphoric acid (HPLC grade) were obtained from MERCK. Methods Diluent Based upon the solubility of the drugs, diluent was selected, Methanol and Water were taken in the ratio 50:50. Preparation of Standard Stock Solutions Accurately Weighed and transferred 10mg and 10mg of Ebastine and Montelukast working Standards into 10ml and 10ml clean dry volumetric flasks separately, add 3/4th volume of diluent, sonicated for 30 minutes and makeup to the final volume with diluents. Preparation of Standard Working Solutions (100% solution) From the above each stock solution, 1 ml was pipetted out into a 10ml volumetric flask and then makeup to the final volume with diluent. Preparation of Sample Stock Solutions 20 tablets were weighed and calculate the average weight of each tablet then the tablet powder weight equivalent to 10 mg of Ebastine and 7.5 mg of Montelukast was transferred into a 10ml volumetric flask, 7ml of diluent added and sonicated for 30 min, further the volume made up with diluent and filtered. Preparation of Sample Working Solutions (100% solution) From the filtered solution, 1ml was pipetted out into a 10 ml volumetric flask and made up to 10ml with diluent. Preparation of Buffer 1ml of OPA was taken in 1000 ml volumetric flask and makeup to the mark with milli-Q water. Preparation of Buffer: 0.01N Potassium dihydrogen orthophosphate (pH 4.8) Accurately weighed 1.36gm of Potassium dihydrogen orthophosphate in a 1000ml of Volumetric flask add about 900ml of milli-Q water added and degas to sonicate and finally make up the volume with water the pH was adjusted to 4.8 with Orthophosphoric acid. RESULTS AND DISCUSSION Method Development Table 1: Different trials were performed by changing Mobile phase and buffer   Trials Column Used Mobile phase Buffer Flow rate Wave length Temperature Injection Volume Trial: 1 Discovery    250 x 4.6 mm, 5m. Water: Methanol (50:50)   1ml/min   244nm   25 ͦ C 10µl   Trial: 2 Discovery          250 x 4.6 mm, 5m. Water: Acetonitrile (50:50) Water   1ml/min   244nm   30 ͦ C 10µl   Trial: 3 Discovery               250 x 4.6 mm, 5m. buffer: ACN (60:40) 0.1%OPA 1ml/min   244nm   30 ͦ C 10µl   Trial: 4 Discovery           250 x 4.6 mm, 5m. buffer: Acetonitrile (60:40) 0.01N KH2PO4 (4.8) solution 1ml/min 244nm   30 ͦ C 10µl   Trial: 5 buffer: Acetonitrile (70:30A)   buffer: Acetonitrile (70:30)   0.01N KH2PO4 (4.8) solution 1ml/min 244nm   30 ͦ C 10µl   Optimized Method   Kromosil 250 x 4.6 mm, 5m.   Buffer: Acetonitrile (60:40) 0.01N KH2PO4 (4.8) solution Diluent                            :   Water: ACN: (50:50) 1.0ml/min 244nm   30 ͦ C 10µl   Table 2: Optimization of chromatographic conditions Trials Observation Trial: 1 Ebastine peak was eluted but Montelukast peak was not eluted and peak shape also not good so further trial is carried out. Trial: 2 Peaks were eluted but peak shape was not good and baseline disturbances hump, USP plate count were not good so further trial is carried out. Trial: 3 Both peaks were eluted but resolution was less so further trial is carried out. Trial: 4 Retention time is more and ebastin eluted at void range so further trial is carried out. Trial: 5 Increasing buffer ratio montelukast retention time is more and ebastine eluted at void range so further trial is carried out. Optimized Method Drugs were eluted with good retention time, resolution; all the system suitable parameters like Plate count and Tailing factor were within the limits. Peak shape and retention time is good so, further process is carried out. Method Validation The present study was carried method was validated based on ICH (Q2B) parameters.8 The following parameters were validated for the proposed method. System Suitability All the system suitability parameters are within range and satisfactory as per ICH guidelines. Table 3 Discussion: According to ICH guidelines plate count should be more than 2000, tailing factor should be less than 2 and resolution must be more than 2. All the system suitable parameters were within the limits. Discussion: Retention times of Ebastine and Montelukast were 2.447 min and 3.436 min respectively. We did not find any interfering peaks in blank and placebo at retention times of these drugs in this method. So this method was said to be specific. Linearity Six Linear concentrations of Ebastine (25- 150ppm) and Montelukast (20-120ppm) were prepared and injected. Regression equation of the Ebastine and Montelukast were found to be, y = 19263x +1149, and y = 19946x + 1095 and the regression coefficient was 0.999.  Table 4 Figure 4 & 5 Precision Intraday precision (Repeatability): Intraday Precision was performed and % RSD for Ebastine and Montelukast were found to be 0.2% and 0.2% respectively. Table 5 Inter-day precision: Inter-day precision was performed with 24 hrs time lag and the %RSD Obtained for Ebastine and Montelukast were 0.3% and 0.2%. Table 6 Accuracy Three concentrations 50%, 100%, 150%, were injected in a triplicate manner and amount Recovered and % Recovery was displayed in Table 7. Figure 6-8 Robustness Small deliberate changes in a method like Flow rate, mobile phase ratio, and temperature are made but there were no recognized change in the result and are within range as per ICH Guidelines. Table 6 Figure 9 & 10 Discussion: Robustness conditions like Flow minus (0.9ml/min), Flow plus (1.1ml/min), mobile phase minus (65B:35A), mobile phase plus (55B:45A), temperature minus (25°C) 3and temperature plus (35°C) was maintained and samples were injected in a duplicate manner. System suitability parameters were not much affected and all the parameters were passed. %RSD was within the limit. Assay Standard preparations are made from the API and Sample Preparations are from Formulation (EBAST M TABLET). Both sample and standards are injected six homogeneous samples. The drug in the formulation was estimated by taking the standard as the reference. The Average % assay was calculated and found to be 99.05% and 99.20% for Ebastine and Montelukast respectively. Table 7 Degradation Studies Standards and degraded samples are injected and calculated the percentage of drug degraded in solution by applying different conditions like acid, alkali, and oxidative, photolytic, thermal and neutral analysis. Table 8 Figure 11-15 Table 3: System Suitability Studies of Ebastine and Montelukast Property Ebastine Montelukast Retention time (tR) 2.447min 3.436min Theoretical plates (N) 8019 ± 63.48 10040 ± 63.48 Tailing factor (T) 1.37 ± 0.117 1.33 ± 0.117 Table 4: Calibration Data of Ebastine and Montelukast Method   S.No     Concentration Ebastine (µg/ml) Response Concentration Montelukast (µg/ml)   Response     1 0 0 0 0 2 25 533631 20 478732 3 50 987156 40 956442 4 75 1467357 60 1501069 5 100 1976938 80 1885033 6 125 2503069 100 2386656 7 150 3011189 120 2913242 Table 5: Repeatability results for Ebastine and Montelukast Sl. No. Ebastine Montelukast 1 1958452 1868712 2 1957170 1870107 3 1952368 1865840 4 1959570 1870800 5 1953581 1865343 6 1952026 1859653 Mean 1955528 1866743 S.D. 3274.9 4115.7 %RSD 0.2 0.2 *Average of six determinations Table 6: Inter-Day Precision Results for Ebastine and Montelukast S. No. Ebastine Montelukast 1 2159276 1882066 2 2168976 1884258 3 2165538 1892454 4 2158679 1885947 5 2162743 1875128 6 2157355 1882066 Mean 2162095 1883653 S.D 4510.1 5671.0 %RSD 0.2 0.3 Table 7: Table of Accuracy Sample Concentration (%) (µg/ml) Recovery (%) Mean % Recovery %RSD Ebastine 50 101.07 99.93% 0.07 100 98.93 0.33 150 99.81 0.30 Montelukast 50 100.8 99.69% 0.08 100 99.63 0.74 150 98.64 0.52 Table 8: Robustness Data of Ebastine and Montelukast S. No Robustness condition Ebastine %RSD Montelukast %RSD 1 Flow minus (0.9ml/min) 0.1 0.2 2 Flow Plus (1.1ml/min) 0.4 0.5 3 Mobile phase minus (65:35) 0.3 0.3 4 Mobile phase Plus (55:45) 0.2 0.1 5 Temperature minus (250c) 0.2 0.2 6 Temperature Plus (300c) 0.3 0.1 Table 9: Assay of Tablet S. No. Ebastine %Assay Montelukast % Assay 1 99.15 98.91 2 99.23 99.19 3 99.00 98.10 4 99.26 99.84 5 98.97 99.46 6 98.67 99.70 AVG 99.05 99.20 S.D 0.2184 0.6339 % RSD 0.2 0.64  Table 10: Different Types of Degradation Studies Types of Degradation EBASTINE Area % Recovered % Degraded Acid 1800991 95.56 4.44 Base 1833505 97.28 2.72 Peroxide 1853657 98.35 1.65 Thermal 1871146 99.28 0.72 UV 1868750 99.15 0.85 Water 1867367 99.08 0.92 MONTELUKAST Acid 1867882 95.28 4.72 Base 1910567 97.45 2.55 Peroxide 1930866 98.49 1.51 Thermal 1950620 99.50 0.50 UV 1951371 99.54 0.46 Water 1947871 99.36 0.64

Figure 1: Structure of Ebastine

Figure 2: Structure of Montelukast

Figure 3: Typical chromatogram of Ebastine and Montelukast            

Figure 4: Calibration curve of Ebastine

Figure 5: Calibration curve of Montelukast            

Figure 6: Accuracy 50% Chromatogramof Ebastine and Montelukast                

Figure 7: Accuracy 100% Chromatogram of Ebastine and Montelukast                

Figure 8: Accuracy 150% Chromatogram of Ebastine and Montelukast                

Figure 9: Flow minus Chromatogram of Ebastine and Montelukast                

Figure 10: Flow plus Chromatogram of Ebastine and Montelukast                

Figure 11: Chromatogram showing Acid degradation                 CONCLUSION A new method was established for simultaneous estimation of Ebastine and Montelukast by RP-HPLC method. The proposed HPLC method was found to be simple, specific, precise, accurate, rapid and economical for simultaneous estimation of Ebastine and Montelukast in the pharmaceutical dosage form. The developed method was validated in terms of accuracy, precision, linearity, robustness, and ruggedness, and results will be validated statistically according to ICH guidelines. The Sample recoveries in all formulations were in good agreement with their respective label claims. Hence the suggested RP-HPLC method can be used for routine analysis of Ebastine and Montelukast in API and Pharmaceutical dosage form. ACKNOWLEDGMENTS I am very much thankful to the management of Seven Hills College of Pharmacy for providing the necessary facilities to carry out the research work and for their encouragement and support. REFERENCES Rana, N. S., Rajesh, K. S., Patel, N. N., Patel, P. R., Limbachiya, U., & Pasha, T. Y. (2013). Development and validation of an RP-HPLC method for the simultaneous estimation of montelukast sodium and ebastine in tablet dosage form. Indian Journal of Pharmaceutical Sciences, 75(5), 599.PMid:24403662, PMCid:PMC3877523 Singh, R. M., Saini, P. K., Mathur, S. C., Singh, G. N., & Lal, B. (2010). Development and validation of an RP-HPLC method for estimation of montelukast sodium in bulk and in tablet dosage form. Indian Journal of Pharmaceutical Sciences, 72(2), 235.https://doi.org/10.4103/0250-474X.65023 ,PMid:20838530  , PMCid:PMC2929785 Yadav, O. M., & Jain, H. K. (2014). RP-HPLC Method Development and Validation for Simultaneous Estimation of Phenylephrine Hydrochloride and Ebastine in Tablet Dosage Form. International Journal of Pharmacy and Pharmaceutical Sciences, 6(8), 466-470. Savsani, J. J., Goti, P. P., & Patel, P. B. (2012). Development and validation of simultaneous equation method for estimation of ebastine and montelukast sodium in combined tablet dosage form. Der Pharmacia Sinica, 3(6), 690-698. Shrikrishna, B., & Nisharani, R. (2015). Analytical Method Development and Validation for Simultaneous Estimation of Montelukast and Ebastine by HPLC. Research Journal of Pharmacy and Technology, 8(1), 1. https://doi.org/10.5958/0974-360X.2015.00001.3 Singh, K., Bagga, P., Shakya, P., Kumar, A., Khalid, M., Akhtar, J., & Arif, M. (2015). Validated UV Spectroscopic Method for Estimation of Montelukast Sodium. International Journal of Pharmaceutical Sciences and Research, 6(11), 4728-4732. Thakor K. A, Pasha, T. Y., Patel P. U., Chauhan R. J., Patel N. H. (2014). Development and validation of analytical method for simultaneous estimation of ebastine and phenylephrine hydrochloride in tablet dosage form. International Bulletin of Drug Research, 4(7): 16-40, 2014. 8. ICH Harmonised Tripartite Guideline, validation of analytical procedures: Text methodology, Q2 (R1) (2005). International Conference on Harmonization, Geneva, pp: 1-13. Read the full article

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acid CAS NO 959236-59-0 2-(2-bromo-6-nitrophenyl)ethanol CAS NO 118665-02-4 2,4-dichloropyridin-3-amine CAS NO 173772-63-9 2,2-dimethylpropanethioamide CAS NO 630-22-8 1-(2-amino-4-methylthiazol-5-yl)ethanone CAS NO 30748-47-1 2-(benzyloxy)-1-bromo-4-fluorobenzene CAS NO 202857-88-3 4-bromo-2-methoxyphenylboronic acid CAS NO 889849-21-2 3-BROMO-4-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER CAS NO 885278-03-5 (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS NO 1268524-70-4 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 458532-88-2 [1-(tert-butyl-dimethyl-silanyl)-5-fluoro-1H-indol-4-yl]boronic acid CAS NO 1093066-72-8 1-(2-amino-4-methylthiazol-5-yl)ethanone CAS NO 30748-47-1 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 452972-13-3 benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylcarbamate CAS NO 1218790-11-4 tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbamate CAS NO 910462-31-6 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 1171891-31-8 2-methoxypyridin-3-ylboronic acid CAS NO 163105-90-6 5-methoxypyridin-3-ylboronic acid CAS NO 850991-69-4 2-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 214360-62-0 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 458532-90-6 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 458532-84-8 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 719268-92-5 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine CAS NO 452972-14-4 2-[(3-CHLOROPROPYL)SULFANYL]PROPANENITRILE CAS NO 940315-21-9 3-cyano-2-hydroxybenzoic acid CAS NO 67127-84-8 1-isopropyl-1H-1,2,4-triazole CAS NO 63936-02-7 3-bromofuran-2-carboxylic acid CAS NO 14903-90-3 tert-butyl 2-carbamoylfuran-3-ylcarbamate CAS NO 655255-07-5 N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine CAS NO 904326-88-1 2-(dibenzo[b,d]furan-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS NO 912824-85-2 4,4,5,5-tetramethyl-2-(furanyl-2-yl)-1,3,2-dioxaborolane CAS NO 374790-93-9 BOC-N-Methyl-L-alanine CAS NO 16948-16-6 pyridine-2,4-diol CAS NO 84719-31-3 tert-butyl 2-bromo-6-chloropyridin-3-ylcarbamate CAS NO 1227958-32-8 6-chloropyridin-2-amine CAS NO 45644-21-1 5-bromo-6-chloro-3-iodopyridin-2-amine CAS NO 1207625-23-7 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine CAS NO 944401-58-5 2-(dibenzo[b,d]thiophen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS NO 912824-84-1 2-(benzyloxy)-1-bromo-4-fluorobenzene CAS NO 202857-88-3 2-(benzo[d][1,3]dioxol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS NO 94838-82-1 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline CAS NO 685103-98-4 4-benzylpiperidine hydrochloride CAS NO 31252-42-3 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine CAS NO 944401-58-5 5-bromo-4-(trifluoromethyl)pyrimidin-2-amine CAS NO 935534-47-7 benzyl 2,4-difluorophenylcarbamate CAS NO 112434-18-1 7-fluoro-1H-indazole-3-carboxylic acid CAS NO 959236-59-0 2-(2-bromo-6-nitrophenyl)ethanol CAS NO 118665-02-4 2,4-dichloropyridin-3-amine CAS NO 173772-63-9 2,2-dimethylpropanethioamide CAS NO 630-22-8 2-chloro-N-methoxy-N-methylacetamide CAS NO 67442-07-3 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)isoxazole CAS NO 832114-00-8

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Phenosafranine, Phenosafranine Manufacturer, Suplier, India

Phenosafranine : We are Manufacturers, Supplier and Exporter Of Phenosafranine, Phenosafranines, Mumbai, India. Call US.

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Safranine 0, Safranine Basic Red 2, Manufacturer, Exporter, India

Safranine 0, Safranine Basic Red 2, Safranines, Manufacturers, Supplier, Exporter, Mumbai, India.

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[midseo]

Safranine 0, Safranine Basic Red 2, Manufacturer, Exporter, India

Safranine 0, Safranine Basic Red 2, Safranines, Manufacturers, Supplier, Exporter, Mumbai, India.

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[midseo]

Basic Violet 8, Basic Violet 8 Manufacturer, Mumbai, India

Basic Violet 8 : We are Manufacturer, supplier and exporter Of Basic Basic Violet 8, Basic Violet 5, Basic Red 2 in mumbai India. Call Now.

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