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bostonmedicalgrouporlando · 5 years ago

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Next Generation & the Future of Erectile Dysfunction Treatments

Erectile dysfunction also synonymously known as ED affects nearly half of men between the ages of 40 and 70 to some extent. Vascular diseases interrelated with aging, hyperlipidemia, smoking, diabetes as well as hypertension, are often linked to erectile dysfunction. Furthermore, injury to cavernous nerves in the penile region “comprises an appreciable number of ED cases.” 6 Other causes of erectile dysfunction include but are not limited to endocrine disorders, as well as fibrosis of the penile tissue and corporal smooth muscle.11 Overall both vasculogenic and neurogenic erectile dysfunctions are linked to the loss of normal cellular function or cell death (apoptosis).

Oral medications such as phosphodiesterase-5 inhibitors (PDE5is), have clear benefits, and are typically first-line treatments in regards to erectile dysfunction, however their actions are short lived.6 Lifestyle changes and injections are also typical first line treatment options for the management of complex cases of erectile dysfunction. Most recently scientists and physicians have been focusing on new next generation novel therapy options as a way to restore natural sexual function; one such treatment option includes Stem Cell based Bioactive Factor Therapy.

Stem-cell-based therapies focus on the management of erectile dysfunction “through the protection of the threatened host cells via immunomodulatory effects, and the provision of trophic factors or gene delivery.”11 In recent years, a number of research studies related to the progress of stem cell-based erectile dysfunction therapy have been published. This is yielding strong evidence supporting the concept that stem-cell-based bio-active therapy is potentially the next generation therapeutic approach for erectile dysfunction. Furthermore, research studies conducted have taken into account a large spectrum of stem cells, including mesenchymal stem cells, tissue as well as muscle -derived stem cells for further investigation in regards to vascular, neural, endothelial or smooth muscle regeneration in animal models for erectile dysfunction.

What are Mesenchymal Stem Cells?

Stem cells are cells that differentiate into smooth muscle cells, neurons, endothelial cells and other types of varying cells. Stem cells by definition have the capability of self-renewal, meaning that they can make copies of themselves for an indefinite period, and differentiate into a variety of phenotypes.1, 2 Stem cells are defined by their “capacity for both self-renewal and directed differentiation. Thus, they represent great promise for regenerative medicine.” Stem cells can be categorized as either embryonic stem cells (ESCs) or adult stem cells (ASCs). Embryonic stem cells (ESCs) are acknowledged as an example of pluripotent cells.6 While multipotent stem cells include mesenchymal stem cells (MSCs) as they “are capable of self-renewal, and they can differentiate into any cell type within their germ layer”.4

Stem cells have diverse properties that make them potentially viable for utilization in various disease treatments. In particular, adult MSCs are “multipotent cells that undergo self-renewal and differentiation” as well as express specific surface markers.13 MSCs can be derived from different sources within the body, including adipose tissue, bone marrow as well as the umbilical cord membrane. 13, 12 Historically, MSCs were founded by a researcher named Friedenstein through the conduction of studies on the bone marrow although MSCs can be isolated from other adult tissues including adipose tissue. 7, 5 The word “Stem Cells” more correctly known as “Mesenchymal Stem Cells” (MSCs) were termed MSCs secondary to their innate ability to duplicate while maintaining the attribute of multi-potential lineage.

MSCs “contain growth factors, signaling lipids, mRNAs, and regulatory miRNAs, which are involved in tissue repair as paracrine mediators.” 13, 14 Research studies have also suggested that exosomes released by MSCs may aid erectile dysfunction linked to diabetes through anti-fibrotic mechanisms, preventing cell death as well as increasing smooth and endothelial muscle content. 15, 18

What are Bioactive Factors and EVs?

MSCs are able to secrete soluble “Bioactive Factors” which aid in modulating the immune system, improve the standard rate of healing injured tissues and reduce inflammation. Stem Cell Bioactive Factors consist of nanoparticles which are released from the membranes of Mesenchymal Stem Cells (MSCs). These nanoparticles contain over “200 Growth factors, Cytokines and Nucleic Acids which support healthy cell-to-cell communication and are responsible for the therapeutic effects observed in regenerative medicine.”

EVs or extracellular vesicles are membrane-packed vesicles that are secreted by MSCs. 9 EVs have been demonstrated to perform a critical role in cell-to-cell communication and important processes such as immune responses, homeostasis maintenance, and more. 8, 9

Microvesicles, an important EV, may “change functional target cells by delivering intracellular proteins”; for example, MVs released from endothelial cells can promote the regeneration through transfer of growth factors and their activators. 12 MSC-derived EVs (MSC-EVs) based stem cell therapies are easier to manage and safer “due to their inability to directly form tumors.” 10

Mesenchymal Stem Cell’s Bioactive Factors

Bioactive Factors demonstrate numerous advantages when compared to Mesenchymal Stem Cells:

Bioactive Factors do not contain DNA as they have no cells therefore there is no risk of a malignant transformation.

Bioactive Factors contain nano-particles which can travel systemically without the risks of clumping.

Bioactive Factors have the ability to cross the Blood Brain Barrier (BBB) and are able to exert their neurotrophic effects.

MSCs can be perceived as “foreign” by our own immune system (both innate and adaptive), however Bioactive Factors are able to evade immune response.

Essentially Bioactive Factors exert far more therapeutic effects than Mesenchymal Stem Cells could.

Therapeutic Effects of Stem Cell Bioactive Factors

Growth factors, Cytokines and Nucleic Acids within Stem Cell Bioactive Factors are catalysts for regeneration as they contribute to tissue and organ repair, alter inflammation, aid in neural communication, improve mitochondrial viability and participate in the alteration of aging cells. Overall Bioactive Factors derived from Stem Cells aid the body in repairing damaged tissues and injuries.

Stem Cell Bioactive Factors have been utilized by Medical Professionals for a number varying aspects including but not limited to soft tissue repair, and restoring sexual wellness. In regards to men’s sexual health Stem Cell Therapy rejuvenates, repairs and regenerates damaged penile tissues, aiding in the restoration of erectile function which may contribute to the elimination the need for long term reliance on drugs.

Some Examples of Bioactive Factors

VEGF (Vascular Endothelial Growth Factors): Aids in the creation of new blood vessels, and in the generation of muscles through bypassing blocked vessels.

PDGF-BB (Platelet Derived Growth Factor Sub Unit B): Stimulates the healing of soft as well as hard tissues.

TGF B3 (Transforming Growth Factor B3): Aids in the conversion of inflammatory T cells into anti-inflammatory Regulatory T cells.

GDF 15 (Growth Differentiation 15): Regulates inflammation and aids in cell repair as well as growth.

How Boston Medical Group Sources Bioactive Factors

Boston Medical Group utilizes Bioactive Factors produced from an FDA-registered Tissue Banks which follow strict GMP guidelines as well as implement and maintain FDA regulations. The Tissue Bank sources from the highest quality donors and harvests from the healthiest part of the placenta in order to produce viable MSCs from which secreted Bioactive Factors are collected at the highest point potency. Upon the completion of manufacturing, each batch is sent for third party testing regarding microbiology and other safety protocols.

Clinic Trials Regarding Stem Cell Therapies and Erectile Dysfunction

Stem Cell Therapy can utilize varying types of stem cells including MSCs. Stem cells may also treat erectile dysfunction by supporting penile tissue through paracrine or hormone effects such as the “release of repair cytokines triggering endogenous mechanisms of regeneration separate from the trans-differentiation of stem cells into different cell types.” 14 Furthermore MSCs do not necessarily need to be engrafted within tissue to create a functional and structural response to the therapy administered.

Phase one studies in humans have shown “results in terms of tolerability, safety, and efficacy of use of stem cell transplant for the treatment of erectile dysfunction.” 18 Recent studies have also suggested that the combination Shock Wave Therapy and Stem Cell Therapy may decrease cell destruction within the penile corpora region as well as promote the growth of new blood vessels. 19

A literature review from ScienceDirect regarding the efficacy of Stem Cell Therapy revealed that five previously completed human clinical trials did show promise for Stem Cell Therapy as “being a restorative treatment option for erectile dysfunction”.20 The five studies included in the literature review utilized different types of stem cells, including various mesenchymal stem cells (MSCs). A total of 61 patients were included in the give studies, with mean ages of men being between 50 and 70 years. The literature review found that the majority of the five studies suggested improvement in erectile function and vascular flow in the penile region due to stem cell therapy without the report of serious adverse events occurring during the follow-up period. 20

Stem Cell Therapy may be a paradigm shift in the growing number of treatment options available for erectile dysfunction. Stem Cell Therapy has been recognized for its therapeutic properties in regards to aiding in treatment for various conditions including erectile dysfunction. Boston NextGen Therapy embraces the latest in advanced technologies to help men restore erectile function without the use of drugs or the long term reliance on drugs. Boston Medical Group utilizes treatment protocols which are personalized to the individual’s conditions and may combine regimens such as shockwave therapy called RejuvaPulse Therapy, BostonPRP Injections and Stem-Cell Bioactive Factors. Thanks to a vast amount continuing research and development, Boston Medical Group physicians have culminated the most efficacious treatment protocols and continue to be the market leader in the field Erectile Dysfunction.

Boston Medical Group’s Optimum Regenerative Solution

Boston Medical Group utilizes the latest in next generation revolutionary treatment options for Erectile Dysfunction while upholding to GMP guidelines, and the utmost standards or requirements regarding the utilization of FDA registered tissue procurement organizations for Stem Cell Therapy. Boston Medical Group utilizes Bioactive Factors and EVs secreted from the membranes of placental-derived MSCs (Mesenchymal Stem Cells) which possess more than 200 growth factors as well as other immune factors which can render considerable therapeutic benefits, especially in the field of Regenerative Medicine***.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib1

https://www.ncbi.nlm.nih.gov/pubmed/18286209

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib3

https://www.ncbi.nlm.nih.gov/pubmed/17254699

https://www.ncbi.nlm.nih.gov/pubmed/23456256?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib6

https://www.ncbi.nlm.nih.gov/pubmed/23456256?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/16458737

https://www.frontiersin.org/articles/10.3389/fphys.2016.00024/full

https://www.mdpi.com/1422-0067/15/3/4142

https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib23

https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib24

https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib28

https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib30

https://www.sciencedirect.com/science/article/pii/S2050052119300964#bib31

https://linkinghub.elsevier.com/retrieve/pii/S1743609517313401

https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2445

https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12871

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735142/#bib95

https://www.sciencedirect.com/science/article/pii/S2050052119300964

Figure 1. https://www.wjgnet.com/1948-0210/full/v11/i9/618.htm#F1

Article source here: Next Generation & the Future of Erectile Dysfunction Treatments

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timclymer · 6 years ago

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10 Health Problems Caused by Computer Use and How to Win Them

If you may spend more than 6 hours per day sitting in front of a computer either for work or pleasure, then it is a high time to self-educate on relevant health-related problems and solutions to be taken.

Regular computer use could be the source of significant health depression due to:

Prolonged sitting position which causes strain in muscles, nerves and blood vessels;

Poor posture triggering bone and organ displacements as well as bad blood flow;

Inappropriate working conditions and environment, including inappropriately adjusted computer / chair / table position, a flickering screen glare and poor eating habits affecting our metabolic reactions and relevant health dysfunctions;

Lack of face-to-face human interaction inclining itself to cyber addiction, depression as well as psychosomatic reactions.

Fortunately, preventive measures as well as an initial treatment of all the health issues caused by a computer use could have been taken on a daily basis, including easy-to-do office exercises.

Health Issues Caused by Computer Use

A sedentary way of life spent in front of a computer screen causes many health problems. The welcome news is that anyone could perform preventive measures to get rid of the symptoms and avoid the diseases caused by prolonged sitting and computer screen glare. Let’s begin by learning all the risks:

1. Neck, Shoulder and Back Pain

These are common problems occurring due to sedentary way of life. If to investigate the background causes of neck, shoulder and back pain (sometimes even leg pain) of white-collars, poor muscle tone, sandwiched nerves, and poor blood circulation are the most widely spread ones. For example, weak spinal muscles could lead to vertebral displacements, which in turn might clench nerves or blood vessels causing terrible back pain and other health issues.

2. Computer Vision Syndrome

CVS or Digital Eye Strain is not one specific eye problem. This health problem encompasses a whole range of eye strain and pain issues experienced by computer users: double vision, irritated red eyes, wet or dry eyes, etc. The symptoms mentioned could have been caused by poor lighting, a digital screen glare, improper viewing distances, poor seating posture, uncorrected vision problems, a combination of the factors (American Optometric Association [AOA], nd).

3. Carpal Tunnel Syndrome

National Institute of Neurological Disorders and Stroke, USA, gives the following description: carpal tunnel syndrome occurs when the median nerve, which runs from the forearm into the palm of the hand, becomes pressed or squeezed at the wrist (NINDS Carpal Tunnel Syndrome Information Page , 2016).

Namely, a painful progressive condition caused by the compression of a key nerve in a wrist is another health issue caused by prolonged computer use, data-entry personnel being at a great risk of acquiring it.

4. Repetitive Strain Injury

RSI is a general term used to describe the pain felt in muscles, nerves and tendons caused by repetitive movement and overuse. The condition mostly affects parts of the upper body: forearms and elbows, wrists and hands, neck and shoulders (National Health Service [NHS], 2016).

5. Metabolic Disorders

Dr. Mercola, an osteopathic physician and New York Times bestselling author, suggests that prolonged sitting is linked to weight gain and associated biochemical changes, such as alterations in hormones, metabolic dysfunction, leptin dysfunction, and inflammation – all of which could promote cancer (Mercola, 2015).

A simple example of a relevant metabolic disorder could be explained by the following logical chain: prolonged sitting causes mushy abdominal muscles, these in turn lead to varied stomach problems trigger obesity, which results from proper breathing and triggers other issues.

6. Heart Diseases

Sedentary lifestyle with its lack of physical activity depresses our muscles. Weak muscles burn less fat. Relevance, blood flows more sluggishly, allowing fat acids to clog easily the heart vessels. When our body’s need for oxygen transmitted with blood is not being met, apart from minor problems (eg incidental arrhythmia), lethal consequences may happen (heart attack and stroke).

7. Brain Blood Circulation Loss

Our brain metabolism may dysfunction due to sedentary way of life. The brain of a healthy individual receives 15% of cardiac blood output and uses 20% of total body oxygen and 25% of total body glucose (Zauner, & Muizelaar, 1997). Accordingly, blood pressure loss across cerebral circulation may possibly be triggered by heart diseases or other reasons of bad blood flow leads to neurotransmitters’ dysfunction, which are the brain chemicals that communicate information through our brain and body. This imbalance can also cause headaches, affect sleep and mood, as well as cause adverse health problems.

8. Leg Degeneration

Legs might also suffer from prolonged sitting. Varicose veins and blood clots could be caused by poor blood circulation in legs. Moreover, weak bones and even hip problems could have the results of poor motion and sedentary habits. All these affect our overall sustaining power and might lead to often fractures when falling.

9. Cyber Addiction

This is a psychological disorder connected with the computer use addiction. Our cognitive abilities decrease, if every single activity is performed through the Internet: shopping, banking, socializing, etc. What is more, cyber addicted people experience a decrease in concentration and focus when doing work off the computer, which makes it very uncomfortable and even dangerous for the society they interact in.

10. Depression

Mental stresses and constant work overloads lead to depressions of the office staff. When the deadline for a project is close, it gets hard to take a break from computer work routine, which involves mental stress. If no preventive measures for improving one’s spirit condition are taken, the rising depression may also cause physical harm.

Ways to Relieve the Symptoms and Prevent the Diseases

It is never late to start caring about yourself! Whether you are an office employee or just use your PC on a daily basis for education or pleasure for prolonged time, the below mentioned ways of preventing computer use problems might be very handy:

1. Back, Neck and Shoulders Strain and Pain Minimization

To minimize pain and strain in your back, neck and shoulders after prolonged sitting, the following measures are required:

Repeated physical exercises,

Properly adjusted working environment,

Proper seating posture,

Regular breaks.

UCLA Spine Center highlights that “No matter how comfortable you are at your desk, prolonged, static posture is not good for your back. Try to remember to stand, stretch and walk at least a minute or two every half hour …” ( Ergonomics for Prolonged Sitting, nd).

2. Overcome Computer Vision Syndrome

It’s not so difficult to arrange appropriate working conditions to prevent CVS. According to already mentioned American Optometric Association, the actions to be taken are:

distribute light with a desk lamp;

put a monitor glare filter,

position your monitor appropriatively – slightly below eye level, about 20 to 28 inches away from the face;

you should not strain your eyes to see the screen;

look away from the screen every 20 min (American Optometric Association [AOA], nd).

3. Prevent / Decrease Carpel Tunnel Syndrome

The initial treatment of CTS, according to American National Institute of Neurological Disorders and Stroke, generally involves resting the affected hand and wrist (NINDS Carpal Tunnel Syndrome Information Page, 2016). Repeated but light exercises may help as preventive measures. For example, a compressed key nerve in your wrist could be preceded by circular wrist movements performed on repeated occasions during a working day.

4. Decrease Repetitive Strain Injury

It is a fact that an inappropriate posture or prolonged activities performed in an awkward position increase the risk of acquaining a strain in muscles or nerves. The first step in preventing the strain injury (which may be pre-diagnosed based on the repetitive pain in muscles or tendons) is to identify and modify the task or activity that is causing the symptoms (National Health Service [NHS], 2016). Breaks from same type activities also help (egwalking to your colleague’s desk instead of sending a message), as well as seating position posture improvement.

5. Improve Metabolism

Our metabolic ability is the basis for digestion, immunity and overall physical strengths. To improve three main causes of metabolism – the conversion of food to energy to run cellular processes, the conversion of food to building materials for proteins / lipids / nuclearic acids, and the elimination of intracellular wastes – it is advised by doctors to follow five easy rules when working in-office:

Performing easy physical exercises on a regular basis,

Regular healthy food eating,

Regular water or tea drinking,

Fresh air breathing,

Working in a comfortable adjusted environment, including good post facilities.

6. Heart Stresses Avoidance

It has been estimated that 80% of heart disease and stroke events may be preceded by lifestyle changes and education, as highlighted by the American Heart Association (Heart Disease Statistics at a Glance, nd). Cardiovascular therapy includes healthy and regular eating, balanced physical activity and regular oxygen intake, as well as avoidance of tobacco and extreme heat or cold temperatures, limited alcohol intake, and mental health maintenance. Considering office employees, occasional meditation, regular tea breaks combined with stairs instead of elevator / fruit instead of cigarette choices may serve as a relevant therapy.

7. Brain Normal Blood Circulation Maintenance

Our brain controls all physical, chemical and mental functions of our bodies. That is why, any brain metabolism drives should be minimized right in advance. As cited by National Center for Biotechnology Information, the importance of auto-regulation of cerebral blood flow that is ensured by constant blood supply and water homeostasis (Cipolla, 2009). To support these processes, one should maintain blood pressure and strengthen blood vessels by balanced physical activities, proper healthy food diet and fresh air oxygenation.

8. Leg Power Generation

Not to let our muscles to degenerate, regular physical activities should be performed on a daily basis. In one of the Forbes journal articles, it is mentioned that eight hours of sitting in an office plus sedentary evening recreation like watching TV – is a recipe for ruin. A survey performed by the National Center for Chronic Disease Prevention and Health Promotion states that nearly 50% of adults in the US admit they do not engage in the recommended 30 minutes, five days a week of moderate physical activity or the suggested 20 minutes, three times a week of violent activity (How much physical activity do adults need, nd).

9. Winning Cyber Addiction

The first step to win the cyber addiction is to get aware of how much time is really being spent on computer disruptive activities like Facebook, Twitter, etc. Computer monitoring software that tracks the Internet and software use might get very handy in analyzing one’s computer use habits. When the data is received, there should be applied some way outs of the addiction. Among others, simple face-to-face human interaction cures the case, as well as fresh air walks and paper publications reading.

10. Overcome Depression

Psychologists suggest the low mood state may affect physical body functions, depressed people experiencing: appetite loss or overeating, concentrating or remembering problems, insomnia or excessive sleeping, fatigue, digestive problems, reduced energy level and many others. To prevent both physical and mental health stresses, – mental therapy, meditation, and spiritual exercises could be performed. Individual approach is advised here: listen to your favorite music, watch or read humorous stuff, or even perform yoga exercises as a short break to your working routine!

Examples of Easy Office Remedies

Why do not some people invest even minimal efforts in preventing computer use and sedentary lifestyle health problems? The answer is quite clear: we’re human beings who are sometimes lazy or even unmindful about regular exercises, and … sometimes too stressed to care about ourselves.

Here are some examples of these simple exercises suitable for offices, – developed to maintain and improve your health while working with a computer:

1. Easy physical exercises:

Example 1 – According to doctors, the right posture cures 70% of health problems caused by long sitting. The rule “90-90-90 degrees of body posture while sitting in front of a computer” is the key to a healthy body!

Example 2 – To cure down problems: sit upright, grasp the left knee, lift left leg off the floor, bend forward (curling the back), bring your nose toward the knee. Repeat 3 – 5 times. Repeat with right leg.

2. Mental Stress Minimization:

Example 1 – Relaxing (or meditating) just three times per day, five minutes each time, will significantly harmonize your inner state. All you need, is to simply sit down comfortably and relax observing calming pictures of nature.

Example 2 – Release stress and generate some energy with a quick-contained dance when no one is looking while having a few minutes break of listening to your favorite music!

3. Natural Advice for Computer Use Harm Decrease:

Example 1 – When sitting for a long time in front of a computer, muscles burn less fat and blood flows sluggishly, allowing fat acids to more easily clog the heart. Allow fresh air into the room to provide your body with oxygen.

Example 2 – Decrease in concentration and focus when doing hourly work on a computer is treated by a short walk to your canteen for a cup of green tea or an apple.

If one does not care about preventing sedentary life problems OR s / he simply forgers to perform regular physical or mental exercises to overcome health issues, it may affect the overall quality of life. This may include enumerated health problems, consequential relationships issues and low work performance abilities (decreased productivity and increased number of professional errors caused by physical fatigue and health stresses). That is why, to live a full life, do not forget to take care about yourself!

References

American Heart Association. (nd). Heart Disease Statistics at a Glance.

American Optometric Association. (nd). Computer Vision Syndrome.

Cipolla, MJ (2009). The Cerebral Circulation. In Morgan & Claypool Life Sciences (Ed.).

Mercola, J. (2015). Here’s What Sitting Too Long Does to Your Body.

National Center for Chronic Disease Prevention and Health Promotion. (nd). How much physical activity do adults need?

National Health Service. (2016). Repetitive strain injury.

National Institute of Neurological Disorders and Stroke. (2016). NINDS Carpal Tunnel Syndrome Information Page.

UCLA Spine Center. (nd). Ergonomics for Prolonged Sitting.

Zauner, A., & Muizelaar JP (1997). Brain Metabolism and Cerebral Blood Flow. In Chapman & Hall (Ed.).

Source by Marysha Resh

from Home Solutions Forev https://homesolutionsforev.com/10-health-problems-caused-by-computer-use-and-how-to-win-them/ via Home Solutions on WordPress from Home Solutions FOREV https://homesolutionsforev.tumblr.com/post/184149066550 via Tim Clymer on Wordpress

#Home Solutions FOREV

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brendalawrence1978 · 6 years ago

Text

10 Health Problems Caused by Computer Use and How to Win Them

Regular computer use could be the source of significant health depression due to:

Prolonged sitting position which causes strain in muscles, nerves and blood vessels;

Poor posture triggering bone and organ displacements as well as bad blood flow;

Lack of face-to-face human interaction inclining itself to cyber addiction, depression as well as psychosomatic reactions.

Fortunately, preventive measures as well as an initial treatment of all the health issues caused by a computer use could have been taken on a daily basis, including easy-to-do office exercises.

Health Issues Caused by Computer Use

1. Neck, Shoulder and Back Pain

2. Computer Vision Syndrome

3. Carpal Tunnel Syndrome

4. Repetitive Strain Injury

5. Metabolic Disorders

6. Heart Diseases

Sedentary lifestyle with its lack of physical activity depresses our muscles. Weak muscles burn less fat. Relevance, blood flows more sluggishly, allowing fat acids to clog easily the heart vessels. When our body's need for oxygen transmitted with blood is not being met, apart from minor problems (eg incidental arrhythmia), lethal consequences may happen (heart attack and stroke).

7. Brain Blood Circulation Loss

Our brain metabolism may dysfunction due to sedentary way of life. The brain of a healthy individual receives 15% of cardiac blood output and uses 20% of total body oxygen and 25% of total body glucose (Zauner, & Muizelaar, 1997). Accordingly, blood pressure loss across cerebral circulation may possibly be triggered by heart diseases or other reasons of bad blood flow leads to neurotransmitters' dysfunction, which are the brain chemicals that communicate information through our brain and body. This imbalance can also cause headaches, affect sleep and mood, as well as cause adverse health problems.

8. Leg Degeneration

9. Cyber Addiction

10. Depression

Mental stresses and constant work overloads lead to depressions of the office staff. When the deadline for a project is close, it gets hard to take a break from computer work routine, which involves mental stress. If no preventive measures for improving one's spirit condition are taken, the rising depression may also cause physical harm.

Ways to Relieve the Symptoms and Prevent the Diseases

1. Back, Neck and Shoulders Strain and Pain Minimization

To minimize pain and strain in your back, neck and shoulders after prolonged sitting, the following measures are required:

Repeated physical exercises,

Properly adjusted working environment,

Proper seating posture,

Regular breaks.

UCLA Spine Center highlights that "No matter how comfortable you are at your desk, prolonged, static posture is not good for your back. Try to remember to stand, stretch and walk at least a minute or two every half hour …" ( Ergonomics for Prolonged Sitting, nd).

2. Overcome Computer Vision Syndrome

It's not so difficult to arrange appropriate working conditions to prevent CVS. According to already mentioned American Optometric Association, the actions to be taken are:

distribute light with a desk lamp;

put a monitor glare filter,

position your monitor appropriatively – slightly below eye level, about 20 to 28 inches away from the face;

you should not strain your eyes to see the screen;

look away from the screen every 20 min (American Optometric Association [AOA], nd).

3. Prevent / Decrease Carpel Tunnel Syndrome

4. Decrease Repetitive Strain Injury

It is a fact that an inappropriate posture or prolonged activities performed in an awkward position increase the risk of acquaining a strain in muscles or nerves. The first step in preventing the strain injury (which may be pre-diagnosed based on the repetitive pain in muscles or tendons) is to identify and modify the task or activity that is causing the symptoms (National Health Service [NHS], 2016). Breaks from same type activities also help (egwalking to your colleague's desk instead of sending a message), as well as seating position posture improvement.

5. Improve Metabolism

Performing easy physical exercises on a regular basis,

Regular healthy food eating,

Regular water or tea drinking,

Fresh air breathing,

Working in a comfortable adjusted environment, including good post facilities.

6. Heart Stresses Avoidance

7. Brain Normal Blood Circulation Maintenance

8. Leg Power Generation

9. Winning Cyber Addiction

The first step to win the cyber addiction is to get aware of how much time is really being spent on computer disruptive activities like Facebook, Twitter, etc. Computer monitoring software that tracks the Internet and software use might get very handy in analyzing one's computer use habits. When the data is received, there should be applied some way outs of the addiction. Among others, simple face-to-face human interaction cures the case, as well as fresh air walks and paper publications reading.

10. Overcome Depression

Examples of Easy Office Remedies

Why do not some people invest even minimal efforts in preventing computer use and sedentary lifestyle health problems? The answer is quite clear: we're human beings who are sometimes lazy or even unmindful about regular exercises, and … sometimes too stressed to care about ourselves.

Here are some examples of these simple exercises suitable for offices, – developed to maintain and improve your health while working with a computer:

1. Easy physical exercises:

Example 1 – According to doctors, the right posture cures 70% of health problems caused by long sitting. The rule "90-90-90 degrees of body posture while sitting in front of a computer" is the key to a healthy body!

2. Mental Stress Minimization:

Example 2 – Release stress and generate some energy with a quick-contained dance when no one is looking while having a few minutes break of listening to your favorite music!

3. Natural Advice for Computer Use Harm Decrease:

Example 2 – Decrease in concentration and focus when doing hourly work on a computer is treated by a short walk to your canteen for a cup of green tea or an apple.

References

American Heart Association. (nd). Heart Disease Statistics at a Glance.

American Optometric Association. (nd). Computer Vision Syndrome.

Cipolla, MJ (2009). The Cerebral Circulation. In Morgan & Claypool Life Sciences (Ed.).

Mercola, J. (2015). Here's What Sitting Too Long Does to Your Body.

National Center for Chronic Disease Prevention and Health Promotion. (nd). How much physical activity do adults need?

National Health Service. (2016). Repetitive strain injury.

National Institute of Neurological Disorders and Stroke. (2016). NINDS Carpal Tunnel Syndrome Information Page.

UCLA Spine Center. (nd). Ergonomics for Prolonged Sitting.

Zauner, A., & Muizelaar JP (1997). Brain Metabolism and Cerebral Blood Flow. In Chapman & Hall (Ed.).

Source by Marysha Resh

from Home Solutions Forev https://homesolutionsforev.com/10-health-problems-caused-by-computer-use-and-how-to-win-them/ via Home Solutions Forev on Tumblr

from Home Solutions FOREV https://homesolutionsforev.wordpress.com/2019/04/13/10-health-problems-caused-by-computer-use-and-how-to-win-them/ via Brenda Lawrence on WordPress

#Home Solutions FOREV

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homesolutionsforev · 6 years ago

Text

10 Health Problems Caused by Computer Use and How to Win Them

Regular computer use could be the source of significant health depression due to:

Prolonged sitting position which causes strain in muscles, nerves and blood vessels;

Poor posture triggering bone and organ displacements as well as bad blood flow;

Lack of face-to-face human interaction inclining itself to cyber addiction, depression as well as psychosomatic reactions.

Fortunately, preventive measures as well as an initial treatment of all the health issues caused by a computer use could have been taken on a daily basis, including easy-to-do office exercises.

Health Issues Caused by Computer Use

1. Neck, Shoulder and Back Pain

2. Computer Vision Syndrome

3. Carpal Tunnel Syndrome

4. Repetitive Strain Injury

5. Metabolic Disorders

6. Heart Diseases

Sedentary lifestyle with its lack of physical activity depresses our muscles. Weak muscles burn less fat. Relevance, blood flows more sluggishly, allowing fat acids to clog easily the heart vessels. When our body's need for oxygen transmitted with blood is not being met, apart from minor problems (eg incidental arrhythmia), lethal consequences may happen (heart attack and stroke).

7. Brain Blood Circulation Loss

Our brain metabolism may dysfunction due to sedentary way of life. The brain of a healthy individual receives 15% of cardiac blood output and uses 20% of total body oxygen and 25% of total body glucose (Zauner, & Muizelaar, 1997). Accordingly, blood pressure loss across cerebral circulation may possibly be triggered by heart diseases or other reasons of bad blood flow leads to neurotransmitters' dysfunction, which are the brain chemicals that communicate information through our brain and body. This imbalance can also cause headaches, affect sleep and mood, as well as cause adverse health problems.

8. Leg Degeneration

9. Cyber Addiction

10. Depression

Mental stresses and constant work overloads lead to depressions of the office staff. When the deadline for a project is close, it gets hard to take a break from computer work routine, which involves mental stress. If no preventive measures for improving one's spirit condition are taken, the rising depression may also cause physical harm.

Ways to Relieve the Symptoms and Prevent the Diseases

1. Back, Neck and Shoulders Strain and Pain Minimization

To minimize pain and strain in your back, neck and shoulders after prolonged sitting, the following measures are required:

Repeated physical exercises,

Properly adjusted working environment,

Proper seating posture,

Regular breaks.

2. Overcome Computer Vision Syndrome

It's not so difficult to arrange appropriate working conditions to prevent CVS. According to already mentioned American Optometric Association, the actions to be taken are:

distribute light with a desk lamp;

put a monitor glare filter,

position your monitor appropriatively – slightly below eye level, about 20 to 28 inches away from the face;

you should not strain your eyes to see the screen;

look away from the screen every 20 min (American Optometric Association [AOA], nd).

3. Prevent / Decrease Carpel Tunnel Syndrome

4. Decrease Repetitive Strain Injury

It is a fact that an inappropriate posture or prolonged activities performed in an awkward position increase the risk of acquaining a strain in muscles or nerves. The first step in preventing the strain injury (which may be pre-diagnosed based on the repetitive pain in muscles or tendons) is to identify and modify the task or activity that is causing the symptoms (National Health Service [NHS], 2016). Breaks from same type activities also help (egwalking to your colleague's desk instead of sending a message), as well as seating position posture improvement.

5. Improve Metabolism

Performing easy physical exercises on a regular basis,

Regular healthy food eating,

Regular water or tea drinking,

Fresh air breathing,

Working in a comfortable adjusted environment, including good post facilities.

6. Heart Stresses Avoidance

7. Brain Normal Blood Circulation Maintenance

8. Leg Power Generation

9. Winning Cyber Addiction

The first step to win the cyber addiction is to get aware of how much time is really being spent on computer disruptive activities like Facebook, Twitter, etc. Computer monitoring software that tracks the Internet and software use might get very handy in analyzing one's computer use habits. When the data is received, there should be applied some way outs of the addiction. Among others, simple face-to-face human interaction cures the case, as well as fresh air walks and paper publications reading.

10. Overcome Depression

Examples of Easy Office Remedies

Here are some examples of these simple exercises suitable for offices, – developed to maintain and improve your health while working with a computer:

1. Easy physical exercises:

2. Mental Stress Minimization:

Example 2 – Release stress and generate some energy with a quick-contained dance when no one is looking while having a few minutes break of listening to your favorite music!

3. Natural Advice for Computer Use Harm Decrease:

Example 2 – Decrease in concentration and focus when doing hourly work on a computer is treated by a short walk to your canteen for a cup of green tea or an apple.

References

American Heart Association. (nd). Heart Disease Statistics at a Glance.

American Optometric Association. (nd). Computer Vision Syndrome.

Cipolla, MJ (2009). The Cerebral Circulation. In Morgan & Claypool Life Sciences (Ed.).

Mercola, J. (2015). Here's What Sitting Too Long Does to Your Body.

National Center for Chronic Disease Prevention and Health Promotion. (nd). How much physical activity do adults need?

National Health Service. (2016). Repetitive strain injury.

National Institute of Neurological Disorders and Stroke. (2016). NINDS Carpal Tunnel Syndrome Information Page.

UCLA Spine Center. (nd). Ergonomics for Prolonged Sitting.

Zauner, A., & Muizelaar JP (1997). Brain Metabolism and Cerebral Blood Flow. In Chapman & Hall (Ed.).

Source by Marysha Resh

from Home Solutions Forev https://homesolutionsforev.com/10-health-problems-caused-by-computer-use-and-how-to-win-them/ via Home Solutions on WordPress

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emmagreen1220-blog · 8 years ago

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New Post has been published on Biology Dictionary

New Post has been published on https://biologydictionary.net/cell-signaling/

Cell Signaling

Cell Signaling Definition

Cell signaling refers to the vast networks of communication that occur between and within each cell in our body. Unlike the stable bricks that lay the foundation of our houses, cells are dynamic and ever-active building blocks. Cell signaling makes this possible. Together, cells are able to coordinate everything from neonatal development to large, cascading immune responses against bacteria or viruses.

Three Stages of Cell Signaling

At its core, however, cell-to-cell signaling can simply be described as the production of a “signal” by one cell that is then received by its “target” cell. In effect, signal transduction is said to have three stages:

Reception, whereby the signal molecule binds the receptor

Transduction, which is where the chemical signal results in a series of enzyme activations

Finally, the response, which is the resulting cellular responses.

Cell Signaling Pathways

Typically, cell signaling is either mechanical or biochemical and can occur locally (autocrine, paracrine), or from a distance (endocrine). The labeling itself is contingent on the distance between the original cell and target cell, and on the physical properties of the signal (“ligand”). Hydrophobic ligands have fatty properties and include steroid hormones and vitamin D3, etc. Following the like-dissolves-like concept, these molecules are able to diffuse across the target cell’s plasma membrane to bind intracellular receptors inside. On the other hand, hydrophilic ligands are often amino-acid derived and will bind to receptors on the surface of the cell; being aqueous allows the signal to travel through the aqueous environment of our bodies without assistance.

The image depicts a cartoon representation of the molecular structure of a protein receptor binding to a ligand.

Types of Signaling Molecules

Signaling molecules are currently assigned one of five classifications.

Intracrine ligands are produced by the target cell itself and bind to a receptor within.

Autocrine ligands are finely distinct in that although they are also made by the target cell, they are first secreted and then later bind to the cell as well as neighboring cells (ex. Immune cells).

Juxtacrine ligands target adjacent cells (often called “contact-dependent” signaling).

Paracrine ligands target cells in the vicinity of the original emitting cell (ex. Neurotransmitters like Acetylcholine).

Lastly, Endocrine cells produce hormones that have the important task of targeting distant cells and often travel through our circulatory system.

Cell Signaling Function and Key Players

As mentioned previously, cell signaling serves a vital purpose in allowing our cells to carry out life as we know it. Thanks to the concerted efforts of our cells via their signaling molecules, our body is able to orchestrate the many complexities that maintain life. These complexities, in effect, demand a diverse collection of receptor-mediated pathways that execute their unique functions.

Intracellular Receptors

A common type of signaling receptor are Intracellular Receptors, which are located within the cytoplasm of the cell and generally include two types. Nuclear receptors are a class of protein with diverse DNA binding domain that, when bound to steroid or thyroid hormones, form a complex that enters the nucleus and modulates the transcription of a gene. IP3 receptors are another class, which are located in the endoplasmic reticulum and carry out important functions like the release of Ca2+ that is so crucial for the contraction of our muscles and plasticity of our neural cells.

Ligand-gated ion channels

Spanning our plasma membranes are another type of receptor called Ligand-gated ion channels that allow hydrophilic ions to cross the thick fatty membranes of our cells and organelles. When bound to a neurotransmitter like acetylcholine, ions (commonly K+, Na+, Ca2+, or Cl-) are allowed to flow through the membrane to allow the life-sustaining function of neural firing to take place, among many other functions!

G protein coupled receptors

Moving on to a diverse family of cell surface receptors, G protein coupled receptors (GPCRs) remain the largest and most diverse group of membrane receptors in eukaryotes. They are special in that they receive input from a diverse group of signals ranging from light energy to peptides and sugars. Their mechanism of action also starts with a ligand binding to its receptor. However, the demarcation is that ligand binding results in the activation of a G protein that is then able to transmit an entire cascade of enzyme and second messenger activations that carry out an incredible array of functions like sight, sensation, inflammation and growth.

Receptor Tyrosine Kinases

Receptor Tyrosine Kinases (RTKs) are another class of receptors revealed to show unforeseen diversity in their actions and mechanisms of activation. The general method of activation follows a ligand binding to the receptor tyrosine kinase, which allows their kinase domains to dimerize. This dimerization then invites the phosphorylation of their tyrosine kinase domains that, in turn, allow intracellular proteins to bind the phosphorylated sites and become “active.” An important function of receptor tyrosine kinases are their roles in mediating growth pathways (i.e., Epidermal Growth Factors, Fibroblast Growth Factors). Of course, the downside of having complex signaling networks lies in the unforeseen ways in which any alteration can produce disease or unregulated growth – cancer. Much is yet to be understood about cell signaling pathways, but one appreciable fact is that the importance they carry is nothing short of monumental.

This figure depicts various forms of RTK and GPCR-mediated Signal Transduction.

Quiz

1. Correctly name the types of signaling molecules mentioned in the article: A. Paracrine, Cytocrine, Autocrine, Endocrine, Pathocrine B. Cytocrine, Autocrine, Paracrine, Intracrine, Juxtacrine C. Intracrine, Paracrine, Autocrine, Endocrine, Juxtacrine D. Exocrine, Autocrine, Paracrine, Juxtacrine, Intracrine

Answer to Question #1

C is correct. The correct five types of signaling molecules are Intracrine, Paracrine, Autocrine, Endocrine, and Juxtacrine signals.

2. Define Endocrine signaling: A. Passage of signal between neighboring cells B. Signal travels distance to target cell C. Emitting cell is also recipient cell

Answer to Question #2

B is correct. Endocrine glands are described to secrete signals (i.e. hormones) into the circulatory system that travel distances to reach their target cells.

3. Name the distinction between Juxtacrine and Paracrine signals: A. Juxtacrine signals are contact-dependent and affect adjacent cells whereas paracrine signals target cells in the vicinity B. Paracrine signals are contact-dependent and affect adjacent cells whereas juxtacrine signals target cells in the vicinity C. Juxtacrine signals travel through the bloodstream to get to target cell, whereas Paracrine signals remain local

Answer to Question #3

A is correct. Juxtacrine signals are described to affect cells they are physically “touching” or in contact with, whereas paracrine signals affect cells in their vicinity that are not necessarily in direct physical contact.

References

Cooper GM. (2000). The Cell: A Molecular Approach. 2nd edition. Signaling Molecules and Their Receptors. Sunderland (MA): Sinauer Associates. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9924/

Boundless.com (2017). Forms of Signaling. Concept Version 6. Date accessed April 29, 2017; available from: https://www.boundless.com/biology/textbooks/boundless-biology-textbook/cell-communication-9/signaling-molecules-and-cellular-receptors-83/forms-of-signaling-380-11606/

Ritter, S.L. & Hall, R.A. (2009). Fine-tuning of GPCR activity receptor-interacting proteins. Nature Reviews Molecular Cell Biology 10, 819-830. Doi:10.1038/nrm2803

Khan Academy (2017). How Cells Signal to Each Other: Ligands and Receptors. Date accessed April 28, 2017; available from: https://www.khanacademy.org/science/biology/cell-signaling/mechanisms-of-cell-signaling/a/signal-perception

Lemmon, M. and Schlessinger, J (2010). Cell. Volume 141, Issue 7; 1117-1134. Cell Signaling by Receptor Tyrosine Kinase. Available from: http://www.cell.com/cell/fulltext/S0092-8674(10)00665-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867410006653%3Fshowall%3Dtrue

#2k #term

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