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Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19

Abstract

Overview of the systemic and organ specific effects of ovine sepsis, the effects of treatment we have observed with intravenous megadose vitamin C and the possible mechanisms of action that require investigation

Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so it is a rational treatment for sepsis. Here, we summarise data that support the use of megadose vitamin C as a treatment for sepsis and COVID-19. Megadose intravenous sodium ascorbate (150 g per 40 kg over 7 h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of Gram-negative bacteria-induced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19.

Conflict of interest statement

YRL, RB and CNM have a provisional patent on vitamin C use in sepsis (2020901120).

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Schools and workplaces are shut-down for an indefinite period of time, public recreational facilities and beaches are closed during the high season spring-break, cities across the country are under lockdown and mayors and governors across the country continue to implement additional drastic Coronavirus measures and directives in an attempt to thwart the spread of the pandemic in the US.

Amidst this unprecedented historical health and financial crisis, the public is in the state of shock, fear and panic, leaving stores across the country empty of necessities, as the White House relentlessly exploring options to avail accelerated FDA approvals for future therapies.

While the public is struggling to adjust with the self-isolation under crisis, there are no solutions in sight as this new breed of vicious pathogens continues claiming lives across America.

Little is currently known on the COVID-19 and it will take significant time to develop FDA approved therapies, cures and vaccines. Historically “the survival of the fittest” concept had proven that during the worst pandemics, those with uncompromised and optimal immune systems were able to survive and thrive. So, what can be done at this time until traditional medicine provides the public safe and effective solutions in forms of prescription drugs or/and vaccines for the notorious COVID-19?

“The ability to evade immune responses is perhaps the most important aspect of viral persistence and proliferation”. Doris Loh

So far we know that China has managed to control the rapid spread of the Coronavirus when the Chinese government officially announced the use of Intravenous vitamin C – IVC- in various clinical studies for COVID-19 coronavirus.

Currently there are three ongoing clinical studies being conducted in China, all implementing the IVC treatment protocol to treat COVID-19 patients.

Dr. Richard Cheng, MD, PhD stated:

“Early and sufficiently large doses of intravenous vitamin C are critical. Vitamin C is not only a prototypical antioxidant, but also involved in virus killing and prevention of viral replication. The significance of large dose intravenous vitamin C is not just at antiviral level. It is acute respiratory distress syndrome (ARDS) that kills most people from coronaviral pandemics (SARS, MERS and now NCP). ARDS is a common final pathway leading to death.”

Sadly, despite this pandemic, panic and pandemonium, politics interfere with this readily available and safe immune boosting and antioxidative protocol. Furthermore, both the conventional as well as social media are more focused on reporting on test-kits and future vaccines, rather than shed light on an established safe and effective therapy, a potentially life saving tool in critical cases.

Case in point – New Zealand Swine-Flu patient on life-support and Vitamin C:

The political war between the traditional allopathic medicine and alternative healthcare is not new. However, now it is once again standing in the way of people’s lives!

Dr. Robert Cathcart who pioneered the Orthomolecular medicine, had safely and successfully treated over 25,000 patients with severe viral and bacterial infections, with high-dose Sodium Ascorbate vitamin C therapy, shared how Vitamin C kills viruses and protects against free-radical damage caused by them:

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Sodium Ascorbate is naturally pH neutral, has two hydroxyl groups instead of one as in Ascorbic Acid, and it harnesses the cell’s intrinsic sodium depended Vitamin C transporter mechanism which improves intracellular ascorbate ion concentration to deliver Maximum Bio-Availability, Absorption, and Potency.

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