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Make sure your hands are clean before applying DMSO, especially since it is efficient at transferring substances through the skin. For acute injuries, apply up to four times daily. For chronic conditions, apply twice daily. It can be used for a few days, a few weeks or indefinitely, depending on the condition. Apply a small amount to the painful area and rub it in. Wash your hands after applying DMSO so that excess is not absorbed by your skin. Avoid contact with toxic substances for three hours. Because DMSO opens up your pores, refrain from being around toxic substances, like lower velocity hydrocarbons and pesticides, for at least three hours after applying DMSO to ensure they are not absorbed into your skin.
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