#zimelidine

[weirdpersonifiedpills]

🌟💊-Welcome!-💊🌟

Heyo, I’m Mouthy (@mouthydraws), welcome to my funny pill blog! I’m an autistic artist with a special interest in pharmacology, specially psychiatric medications, more specifically antidepressants, even more specifically SSRIs. A lot of the stuff I post here will be older until I’m able to catch up, but that hopefully won’t take too long!

New blog for my medication personifications? First post obviously has to be the SSRI lineup from 2022, here come the white-tailed deer ready to fight for your mental health!

From left to right: Zelmid (zimelidine), Luvox (fluvoxamine), Prozac (fluoxetine), Zoloft (sertraline), Paxil (paroxetine), Celexa (citalopram), and Lexapro (escitalopram)

SSRIs (Selective Serotonin Reuptake Inhibitors) are a class of antidepressants used to treat a variety of mental illnesses, most notably anxiety disorders and depression. They’re my absolute favorite class and the reason I’m currently in college for pharmacology. Prozac’s history in particular is my favorite to read about, so expect plenty of him and his history lol.

F.A.Q.

What are personified pills?

Personified pills are, as the name suggests, personifications of medications. Each aspect of the character, from their design to their personality, is carefully chosen based on historical, chemical, and pharmacological aspects of the actual medication. I enjoy drawing the characters in scenes that reference the real-life history of said drug.

Are these your OCs?

Yes. While I don’t own the idea of personifying medications, the designs and characters themselves do belong to me. You’re welcome to design your own personifications, or use mine with credit!

Why are they animals/furries?

Each class of drugs is a different animal species, I think it adds a lot to the characters, and specific animals are chosen in the same way every other aspect of the characters are chosen. Having the characters be animals also allows for clear distinctions between drug classes. I don’t enjoy drawing humans, but even if I did, I’d still keep them as animals.

Do you have a personification for *insert medication here*

All of my personifications are on my Toyhouse (@mouthydraws) under the ‘Medications’ folder. It can take some background knowledge on the class of the drug/possible subclasses or categories to find some of them, so I’ll also be uploading all of them here and using tags to make them easier to locate. If you have a specific medication you want to see, feel free to let me know!

Will you personify illegal drugs?

Given that most illegal drugs either didn’t start out as illegal or are only illegal in certain forms/circumstances, yes. I’ve started on the opioid personifications, and diacetylmorphine (her0in) is definitely going to be a part of that, as well as ADHD medications, which means m3thamphetamine hydrochloride (crystal m3th) is also on the horizon.

Are real people/names included in character lore?

No, I try to keep real people out of the personified pill lore, as it is fiction that’s simply based on actual events. A lot of the history behind these medications can be upsetting, and I do my best to treat these events with the respect they deserve. I’ll talk a lot about drug companies (Eli Lilly, Pfizer, Novartis, AstraZeneca, etc. etc.) but I won’t mention anyone specific lore-wise. I enjoy talking about drug history OUTSIDE of these characters, and will probably do that here too (with appropriate tags of course).

My inbox is always open, but I’m more active on Instagram and Twitter (@mouthydraws). I post a lot of WIPs and general pharmacology ramblings on my Instagram stories, so if you’re interested come check it out! I’m always looking for more pharmacology mutuals!!

[macgyvermedical]

Requesting a history of diphenhydramine! I read somewhere that it was the first discovered SSRI, but can’t remember where.

This will be the history of diphenhydramine as an SSRI and the drugs surrounding it. The history of diphenhydramine as a whole is longer than my standard post length and I would want to do it justice!

It was technically the first available SSRI (becoming available by prescription in 1946), but it's SSRI activity was not discovered until the 1960s, after the SSRI activity of brompheniramine (available 1955) was discovered.

Brompheniramine was the first antihistamine to be studied as an antidepressant, as it was noted to have antidepressant properties strong enough to be usable. Out of this research came the antidepressant drug zimelidine, which went to market in 1982. Two years later, this drug would be withdrawn due to reports of Guillain-Barre syndrome.

Diphenhydramine does not have antidepressant effects strong enough to be usable, but it does weakly inhibit serotonin reuptake. Out of research into the antidepressant potential of diphenhydramine, the antidepressant fluoxetine (Prozac) was created. Fluoxetine went on the market in 1986 and is the 25th most commonly prescribed drug in the US today.