#you gave me zero context lmaooooo

[luckyagain]

You're 25 have some shame

i am 25 so at least my pre-frontal cortex is fully developed unlike yours :)

anyway i'm learning about anti-platelet and anti-coagulant drugs in school right now. and i'm gonna use your anon to brain dump everything i know so that some actual use can come from the three seconds of my life i wasted reading this. okay so from my understanding when there is an injury that causes bleeding the injured endothelial cells release endothelium which promotes vasoconstriction of the smooth muscle cells to prevent blood loss. they also secrete von willebrand factors which bind to the collagen that the endothelial cells reveal underneath them. the platelets are just zooming by in our blood but they stop and bind to the von willebrand factors via their gpIb receptor, this binding also leads to a localized effect. this causes platelet activation and degranulation of thrombin, serotonin, thromboxane A2, and ADP. the thrombin binds to the PAR-1 receptor on the surface of the cell and further promotes platelet activation. TXA2 promotes vasoconstriction and helps promote the activation of the GP2B3A receptor. ADP can bind to either the P2Y1 or P2Y12 receptors, when it binds to P2Y1 it causes an increases in intracellular calcium. when it binds to P2Y12 it leads to a breakdown of cAMP via phosphodiesterase which eventually can lead to the activation of the GP2B3A receptor on the surface of the cell. the fibrinogen is able to bind to the GP2B3A receptor and then be converted into fibrin in order to start the linkage and meshwork surrounding the platelets. and then you have the whole coagulation cascade going on that i don't feel like explaining right now. you have COX-1 inhibitors like aspirin which irreversibly inhibit, via acetylation, the COX-1 enzyme that produces TXA2 so those levels will decrease leading to less vasoconstriction and less activation of the GP2B3A receptor. aspirin has adverse SE like GI issues like ulcers because in inhibiting COX-1 it's preventing COX-1 from producing PGE2 which helps protecting the stomach lining from the stomach acid. aspirin "allergies" work similarly, you can have bronchospams because PGE2 promotes bronchodilation. another class of anti-platelets would be P2Y12 inhibitors. your first-line would be clopidogrel, however, there is some genetic variability in how patient's react to it because it is a pro-drug. other pro-drugs that are irreversible inhibitors are prasugrel and ticlopidine, the latter is specifically not a first-line because it has an adverse effect of causing neutropenia. a P2Y12 ihibitor that is not a pro-drug and is reversible is ticagrelor. all four of these drugs have a rare SE of TTP. You also have PDE inhibitors that prevent phosphodiesterase from breaking down cAMP which would prevent the expression of the GP2B3A receptor. those are cilostazol and dipyridamole, the latter of which is on the beer's list and should not be prescribed to the elderly because there is an increase fall risk associated with it due to it cause orthostatic hypotension. there's also GP2B3A inhibitors that are only administered IV in hospitals because they have short-term effects so that means they are reversible; they are also used when patients are allergic to P2Y12 inhibitors. lastly, you have par-1 inhibitors like vorapaxor that prevent thrombin from binding to the par-1 inhibitor which will decrease platelet activation. and that's all i got because i don't feel like talking about anti-coagulation drugs right now.

[makeste]

BnHA Chapter 291: The Endeavor Pamphlet

Previously on BnHA: Dabi showed up atop Gigantomachia’s back and was all “you’ll never guess who I really am!” and the readers humored him and were all “who?” and he was all “TODOROKI TOUYA” and we were all “WOW └(・。・)┘ OH MY GOSH I WOULD NEVER HAVE GUESSED”, except for Shouto and Enji who were GENUINELY SHOCKED. Anyway so Touya was all “and guess what I’m doing right now!” and before anyone could even try, he was all, “STREAMING MY EMMY-NOMINATED MINISERIES ‘HELLO, I’M EVIL BUT ALSO TRAGIC AND SEXY, NOW LET ME TELL YOU ALL ABOUT MY DAD WHO SUCKS’’, THAT’S WHAT.” And everyone was all “oh my god” and Touya was all “ヽ(⌐■_■)ノ♪” for basically the rest of the chapter, and that’s pretty much it! Oh, wait, except for the part where he also doused himself in bleach in a fit of pure theatrics, which is actually pretty much the main takeaway from the entire chapter really because it was just wild af. ANYWAYS.

Today on BnHA: Horikoshi introduces Baby Touya, the world’s most enchantingly sweet character, and is immediately all, “I sure can’t wait to tell you guys all about how his fucking jaw burnt off.” Thankfully he doesn’t (YET), and we cut back to the present pretty quickly, where Dabi explains how he took all of his brain cells that should have been used to stop him from pouring bleach over his head, and instead put them all toward his big brain plot of releasing an elaborate video detailing Endeavor’s various abuses and crimes, and even throwing Hawks under the bus as well because WHY NOT. He then leaps off of Gigantomachia’s back (like I said, no brain cells) all set to blast them with a Prominence Burn, only to be stopped by none other than THE LEGEND HIMSELF, MOTHERFUCKING BEST, PRETTIEST, NICEST, MOST OUTSTANDING MOTHERFUCKING JEANIST. Who’s no doubt outraged by the crime against hair he witnessed only moments earlier. GO GETTIM JEANY BOI.

so I haven’t had time to answer any of them because this has been the stupidest week, but I just wanted to tell you guys that I received no fewer than nine asks about Dabi’s hair. which, in a week filled with election memes and tumblr’s most cursed fandom briefly rising back up from the dead, is a pretty impressive feat for him if you ask me. like, I know I was making fun of it basically nonstop, but it sure did generate a lot of discussion so maybe I should rethink my opinions on Dabi’s PR strategies now, idk

anyway. it’s Saturday. time to catch up on this shit. let’s see how fucked the Todorokis are

OH NO HE’S CUTE

HOLY SHIT THIS IS TOO MUCH TO FUCKING PROCESS. I’M JUST TRYING TO ENJOY MY DAY HORIKOSHI, ARE YOU REALLY GOING TO TRAUMATIZE THIS POOR CHILD RIGHT IN FRONT OF MY SALAD

“thanks for being all right” the fuck

who allowed this child to be so cute. I’m serious. who signed off on this

how could a child this adorable possibly want to murder his equally adorable baby brother. please, your honor. there must be some mistake here

guess how prepared I am to read all about Touya’s tragic past. mm. that’s right. zero ready. none ready

anyway. TWO THOUSAND DEGREES LOLOLOL. NO TRACE OF A CORPSE HOW CONVENIENT. A PIECE OF HIS LOWER JAW BONE FFFFMSGHKLSh. LOVELY. LOVELY

LMAOOOOO

listen you guys. I just want to take a moment to appreciate that Horikoshi Kouhei did one of two things here. either (1) he planned it out FROM THE VERY START that Touya would be born with red hair Because Fire Powers, but would then have his hair turn white due to trauma, thus making the Dabi/Touya connection very slightly less obvious, although Let’s Be Real Who Are We Kidding. OR, (2) the anime got it wrong and gave him red hair, and rather than allowing this plot hole to continue to exist, Horikoshi took it upon himself to concoct this elaborate storyline and pretend it was never a plot hole at all! in which case I sure hope someone at Bones is sending him a VERY nice Christmas card this year. got this man sweeping up all your messes for you. you’re just lucky he has some sort of wild compulsion to address these things

anyways!!

FATHER AND SON. how sweet. :| still zero percent ready for any of this btw

STOP BEING CUTE

THIS IS RIDICULOUS. I’M SO MAD RIGHT NOW. HE IS THE SINGLE CUTEST CHARACTER IN THE ENTIRE SERIES, and do you even know how many other baby characters I’m betraying in order to say that?! baby Kacchan, baby Deku, baby Ochako, baby Shouto, Eri, baby Hawks. I’M LOOKING YOU DEAD IN THE EYE RIGHT NOW AND TELLING YOU THAT BABY TOUYA IS CUTER THAN ALL OF THOSE PLEBS. AND YOU’RE LOOKING BACK AT ME RIGHT NOW ALL “YEAH IT SURE IS A PITY ABOUT HIS JAW MELTING OFF THOUGH.” THAT’S IT, I QUIT THE SERIES

and Enji’s smiling at him. he’s so proud of him. but then Touya won’t be able to do it, and Enji’s gonna stop training him, and Touya’s gonna feel like a failure and keep pushing himself in order to try and win his dad’s affections back, because that’s all kids fucking want, all they want is just love, that’s fucking it, you couldn’t just give him that?? and then he’s gonna immolate himself fflkdlskfh THERE YOU SEE HORIKOSHI, I KNOW THE WHOLE STORY ALREADY, YOU DON’T HAVE TO DO THE WHOLE “SHOW THEM THE DEAD DOG” THING YET AGAIN YOU PIECE OF SHIT

OH SNAP THERE GOES THE TWIN THEORY. R.I.P.

BABY FUYUMI. PRETTY CUTE. NOT AS CUTE AS TOUYA THOUGH. HEY LOOK, NO REASON TO GET MAD AT ME I’M JUST STATING A FACT HERE

YEAH THIS IS GONNA GO REAL WELL OH BOY

I keep pressing the emergency stop button but this industrial tragedy machine just keeps on chugging along anyway, I’m pretty sure this thing is not up to code

:| I am so sorry sweet boy, Horikoshi is only getting started with you

FUCKING HELL WITH THIS NARRATION

but he wasn’t actually a child to you, he was just a little puppet child for you to live vicariously through!! and then you went and did the same fucking thing with Shouto afterwards and never learned your lesson until just six months ago!! fucking hell, Enji

so now he’s all “Touya is dead, that’s an unforgivable lie” fflkdhflk motherfucker does he look dead to you. if you really think that, tumblr and twitter have got a little over five years’ worth of archived theory posts to show you

oh shit Touya’s countering with “it’s an unforgivable truth”, which, damn. I actually think Horikoshi’s dialogue is one of his weaker points as a writer a lot of the time, but that comeback was snappy as fuck

actually guys, now that I’ve seen how ridiculously fucking cute baby!Touya was, I can almost understand why Shouto and Enji never put the pieces together before lol. any passing similarities would have easily been dismissed on account of he’d need to be at least 10x more adorable in order to get the full resemblance

OH MY GOD

NOW YOU SLEEP??? SO YOU POINT BLANK REFUSED TO PASS OUT WHILE YOU WERE BUSY MAIMING ALL OF MY FAVORITE CHARACTERS, BUT NOW THAT THERE’S AN OPPORTUNITY TO SEE YOUR REACTION TO THE “YOUR LIEUTENANT WAS SECRETLY RELATED TO ONE OF YOUR WORST ENEMIES THE WHOLE TIME” BOMBSHELL, YOU FINALLY DECIDE TO GET YOUR FORTY WINKS. I SEE

WOW DABI

I’M SURPRISED YOU DIDN’T ALREADY HAVE YOUR ANCESTRY.COM RESULTS PRINTOUT READY TO FOLD INTO A PAPER AIRPLANE AND ZOOM ON DOWN TO HIM

LOL NEVERMIND

gotta say, so far The Endeavor Pamphlet is just about as spicy as I could have hoped

(ETA: Natsuo’s face as he watches his beloved dead brother come back to life only to literally and metaphorically set everything on fire in one fell swoop is :/. why must you do this to me Natsu. can’t you see I’m trying to throw a Welcome Back Jeanist party here.)

HAVE YOU READ THIS?! TODOROKI ENJI ABUSED HIS OWN HEIR, AND DABI WROTE IT DOWN RIGHT THERE

WELL HE’S NEVER GON’ BE NUMBER ONE NOW / NEVER GON’ BE NUMBER ONE NOW / THAT’S ONE LESS THING TO WORRY ABOUT / THAT’S ONE LESS THING TO WORRY ABOUT

btw I neglected to mention this last week, but yes I do recognize and appreciate that this is Can’t Ya See-kun himself whom Horikoshi has chosen to be the face of this existential crisis which the general public is about to experience. rip CYS-kun

OOF

excuse me. putting aside the implications of Dabi sharing this context-less murder video of Hawks with the entire world for a moment, I just have to pause for a sec here, because when exactly did he get a chance to edit this all in?? complete with voiceover that seamlessly ties in with the prerecorded footage of him with DNA test results sans shirt?? you’re telling me this motherfucker, with all the smoke that was in the room thanks to his own quirk, somehow got a PERFECT SHOT of the PRECISE MOMENT when Hawks drove his feather knife into Jin’s back, using his MAGIC CAMERA THAT HE I GUESS HAD THE ENTIRE TIME IN THE POUCH RIGHT NEXT TO HIS BLEACH BOTTLE, and then immediately somehow got this very next shot as well FROM AN ENTIRELY DIFFERENT ANGLE

ALL THE WHILE IMMEDIATELY RUNNING THROUGH SCRIPT REVISIONS IN HIS HEAD, WHICH HE THEN PROCEEDED TO RECORD... WHERE, EXACTLY?? WITH SKEPTIC, WHILST RIDING ON MACHIA’S BACK??

AND THIS IS ALL YOU HAVE TO SAY FOR YOURSELF???

and this after I just wrote that whole long paragraph positively GLOWING about this man’s ability to plug up a plot hole. jfc. just scratch out every damn word I said lol. just forget all of it

are you fucking kidding me, the footage was from the cameras Skeptic planted on Hawks??

that’s... actually... okay you know what, it still doesn’t make any sense in the slightest, but the determination to address it nonetheless... just, dammit... I feel like I’m constantly at war with myself over whether or not I want to shake this man’s hand or slap him lmao. whatever, then!!

anyway, since Shouto and Enji can’t actually see the damage that Touya is dealing to the hero industry even as they speak, Touya is taking it upon himself to give them the highlights

I think it’s a testament to how much Endeavor cares about Hawks that he managed to zero in on that comment even amidst all the craziness of his eldest son returning from the dead to announce how he’s been carefully plotting their destruction for years and years. like, he heard “Hawks” and his face immediately went like that. you think he’s worried that Dabi did something to him? because he’d be right to worry lol

so the Endeavor Pamphlet narration is now explaining all about how Hawks totally killed the Number 3 Hero Best Jeanist as well! yep... he sure did... totally...

OH MY GOD WE’RE CUTTING TO HIM AHHHHH

Hawks, that is. lol. not Jeanist. NO, JUST MY POOR HALF-DEAD WINGLESS BABY SON

NOOOOO HIS LITTLE WING STUMPS. BUT SOMEHOW HIS FACIAL HAIR IS STILL INTACT. OH TO BE AN ANIME PRETTY BOY BEING SET ON FIRE. “HEY, TAKE IT EASY, WATCH THE FACE”

EXCUSE ME WHAT

interesting! we suspected as much, I think, with the clues that Ending dropped, and the little flashback right after the name reveal. still not clear how Dabi found out about it though!

looooool okay here we go, breaking out the heavy-handed holier-than-thou shit now

you know, I do find it interesting how trying to model themselves after All Might’s noble Symbol of Peace image has kind of ended up being the heroes’ undoing here. like, I could write a whole essay on this, but what it basically boils down to is that they were all trying too hard to be perfect. All Might went out there and did his thing and was amazing, and so the powers-that-be built an entire system centered around this seemingly-infallible person, and they acted like the system was infallible as well. and so most of the population ended up becoming complacent over the years, and meanwhile the people who were unfortunate enough to fall through the cracks understandably wound up disillusioned and perceiving the heroes as these false idols

anyway, but I think one positive takeaway from this is that the new up-and-coming generation of heroes represent a breakaway from that system. like, imo what we’re witnessing is the downfall of the Perfect Hero, and the rise of the imperfect hero. and this new generation doesn’t shy away from their failures or pretend like they never happened. they pretty much can’t pretend, because their failures are all right out there in the open for everyone to see. Bakugou Katsuki, just to name one example off the top of my very biased head, has had his own personal character journey basically play out right in front of the media’s eyes. his humiliation at the sports festival, his kidnapping by the League, and all of the fallout afterward. this isn’t someone who can ever go out there and convince the world that he’s perfect. but what he can do, instead, is show the world that he’s trying. that he’s trying with everything he has to do his best, to be the best. rather than this untouchable godlike image, it’s instead the image of someone painfully human who is nonetheless striving with everything he’s got to keep moving forward, flaws and all, and work his way to the top

and ultimately I think that’s going to be a much more positive image to send out to the world when all’s said and done. because rather than merely inspiring awe, heroes like that inspire people to take action themselves. or at least that’s what I hope! and not just Bakugou, but the others as well. we’ve got Shouto, whose own personal trauma is being aired in front of the whole nation even as I sit here ranting. we’ve got Deku, who cries at the drop of a hat, and who fought to become a hero despite being quirkless (and I think it’s only a matter of time before that eventually becomes public knowledge as well). tl;dr because I’m getting way too long-winded here, but these kids have effectively been humanized in a way that the old generation never was, and I think that’ll go a long way towards building trust between them and the people they’ll someday be protecting, and inspiring the next generation in hopefully a much healthier way

anyway so where were we. ...oh yes, Dabi was explaining that heroes only protect themselves, and is presumably building up to his grand conclusion of “therefore you should all just let the villains take over and burn down the world”

omfg. YOU GUYS

DOES CAN’T YA SEE-KUN’S SHARK FRIEND ACTUALLY CALL HIM “CAN’T YA SEE-KUN.” HE HAS A NAME YOU KNOW!! UNLESS HE LEGALLY GOT HIS NAME CHANGED TO CAN’T YA SEE-KUN. OH MY GOD

ALSO, IS THAT CAN’T YA SEE-KUN CRYING IN THE BOTTOM RIGHT THERE OMG. GIVE THIS CHILD A HUG. EVERYONE STOP WHAT YOU’RE DOING RIGHT NOW AND HUG HIM

BAKUGOU IS BARELY HANGING ON THERE LOL. GOTTA STAY CONSCIOUS... SO MUCH TEA BEING SPILLED... FOCUS... CONCENTRATE

IIDA’S ANGLING HIS HEAD IN A WEIRD WAY, LIKE DUDE. LOOKING SUSPICIOUSLY SNUGGLY THERE. MMM THESE IIDABAKU CRUMBS

HADOU IS ALL “WHAT EVEN IS ACTUALLY GOING ON” LMAO

LASTLY, POOR SHOUTO OMFG. WHEN YOU’RE ALL FINISHED HUGGING CYS-KUN THIS CHILD NEEDS YOUR ATTENTION!!

so now Dabi’s leaping off of this ninety-foot-tall gargoyle man like that’s a normal, smart thing to do. unless he can fly too now? saw his dad doing it back at Fukuoka and was all “hmm”

OH MY GOD SOMEONE TELL ME RIGHT NOW WHAT WORD SHOUTO IS USING TO ADDRESS ENJI, THESE TRANSLATIONS LOVE TO MESS WITH MY HEAD

ENJI GET MOVING DO YOU NOT SEE THOSE TEARS!!! SNAP OUT OF IT YOU BIG TREE

AHHHHH

OH KACCHAN YOU WOKE UP A LITTLE MORE THERE, HUH

lol he and Deku both look so determined but they’re basically sitting ducks. their “oh shit” faces do look remarkably like their “TIME TO SWING INTO ACTION” faces but don’t be fooled, they have one good arm and about six pints of blood left between the two of them. looks like this one’s all on you Shouto

-- AHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH --

BAH GOD... WHAT’S GOING ON HERE... THAT’S BEST JEANIST’S MUSIC

y’all. can’t even talk right now, my brain has completely shut down lol. just. ...

  °˖✧◝(￣▿￣)◜✧˖°