#wtips

[w-tips]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost+-+Sem+ttulo++Tumblr

[pinkbeargladiator]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost

[blogtips]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost

[inkaperescapades]

How did Frieae's size change impact the area around you?

Well, the mount^in r^nge is gone. ^s is the forest. She c^rved ^ new c^nyon trench ne^rby with her cl^wtip, ^nd I'm sure most of Extern^'s geogr^phy h^s TONS of new imp^ct cr^ters from where she's stepped ^nd s^t down.

[gamtosthegreat]

Gotta do everything myself on this fuckass webbed site, here is your slushy wave sounds you cocks

[wednesdaystips]

Por que o Brasil tem a população mais depressiva da América Latina - Trends WTips

[rnomics]

Biomolecules, Vol. 13, Pages 1401: Presenilin-1-Derived Circular #RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer’s Disease

The presenilin-1 (PSEN1) gene is crucial in developing Alzheimer’s disease (AD), a progressive neurodegenerative disorder and the most common cause of dementia. Circular #RNAs (circ#RNAs) are non-coding #RNA generated through back-splicing, resulting in a covalently closed circular molecule. This study aimed to investigate PSEN1-gene-derived circular #RNAs (circPSEN1s) and their potential functions in AD. Our in silico analysis indicated that circPSEN1s (hsa_circ_0008521 and chr14:73614502-73614802) act as sponge molecules for eight specific micro#RNAs. Surprisingly, two of these #miRNAs (has-mir-4668-5p and has-mir-5584-5p) exclusively interact with circPSEN1s rather than #mRNA-PSEN1. Furthermore, the analysis of pathways revealed that these two #miRNAs predominantly target #mRNAs associated with the PI3K-Akt signaling pathway. With sponging these micro#RNAs, circPSEN1s were found to protect #mRNAs commonly targeted by these #miRNAs, including QSER1, BACE2, RNF157, PTMA, and GJD3. Furthermore, the #miRNAs sequestered by circPSEN1s have a notable preference for targeting the TGF-β and Hippo signaling pathways. We also demonstrated that circPSEN1s potentially interact with FOXA1, ESR1, HNF1B, BRD4, GATA4, EP300, CBX3, PRDM9, and PPARG proteins. These proteins have a prominent preference for targeting the TGF-β and Notch signaling pathways, where EP300 and FOXA1 have the highest number of protein interactions. Molecular docking analysis also confirms the interaction of these hub proteins and Aβ42 with circPSEN1s. Interestingly, circPSEN1s-targeted molecules (#miRNAs and proteins) impacted TGF-β, which served as a shared signaling pathway. Finally, the analysis of microarray data unveiled distinct expression patterns of genes influenced by circPSEN1s (WTIP, TGIF, SMAD4, PPP1CB, and BMPR1A) in the brains of AD patients. In summary, our findings suggested that the interaction of circPSEN1s with micro#RNAs and proteins could affect the fate of specific #mRNAs, interrupt the function of unique proteins, and influence cell signaling pathways, generally TGF-β. Further research is necessary to validate these findings and gain a deeper understanding of the precise mechanisms and significance of circPSEN1s in the context of AD. https://www.mdpi.com/2218-273X/13/9/1401?utm_source=dlvr.it&utm_medium=tumblr

[nonomesg]

Tips For Choosing the Best Valentine’s Dress from Nonome’s Latest Collection

Whether you’re looking to make a statement at an upcoming event or want to feel extra special on your date night, our new arrivals have everything you need! In this blog, we shall discuss seven tips to consider while picking the new arrival dress that is perfect for you.

[organicbindia]

@organicbindia order your organic B bamboo Q-tips now!! .@instagram . . . #organicb #organicbindia #amazon #india #supportus #nation #wtips #bamboo #world #bamboo #bamboomission #bambooworld #noida #delhi #pollution #airpollution #world #instagram #firstcry https://www.instagram.com/p/CWGJeDevnon/?utm_medium=tumblr

[coinandcandle]

"SAH-WEN"??? (Samhain)

It's that time of year again! It's October, the leaves are turning colors, the pumpkin spice craze is back. Yes, Samhain!

So first... yes it's pronounced Sah-wen, but I can't help but say it in my head as Sam-hayne, sue me.

What is Samhain?

Samhain is one of four ancient Fire Festivals that many witches, druids, and pagans alike celebrate. Samhain is on October 31st and November 1st in between the fall equinox and the winter solstice. It marks the end of harvest season and the beginning of winter. This is also the ancient Celts' New Year day. It is also a time to celebrate the dead or ancestors. They believed that the veil between worlds was thinnest on this day.

Where Did Samhain Originate?

Ancient Celts were the folks who are first recorded to celebrate Samhain, hence it's name being an old Gaelic name. However, Celtic revivalists and other pagans have helped the holiday gain more popularity over the years.

What are Some Samhain Traditions?

The oldest traditions of Samhain involve putting out the hearth's fire in their homes, harvesting crops, and lighting a community bonfire. They did this by using a wheel that which would then cause friction and spark a fire. This wheel represented the sun and was used along with prayers. They would offer sacrifices of cattle and when the festival was over, take a flame form the community fire home with them to relight their own hearth.

More modern tradition include:

Bonfires

Creating Alters for the dead or for associated deities

Creating Feasts

Making Pastries

Communing with Spirits

and more!

Can I Celebrate Samhain?

Despite what some people (though very few) will tell you, anyone of any origin can celebrate Samhain! Just be sure to educate yourself and don't disrespect the ancient tradition or deities involved in this sacred holiday.

Associations:

(These are not Traditional associations, they are modern pagan associations)

Revision!!! : Cailleach, the divine hag (literally means old woman or hag) and goddess of winter is very important during this time since she is in charge of the weather from Samhain to Beltane. I encourage you to look deeper into her as she is very interesting! You can read more about her here and I will make a whole post about her eventually!

Deities: The Morrigan is one of the main deities associated with this day, however, over the years as paganism has become a melting pot of pantheons, people have also considered other gods to be associated with the holiday such as: Pomona, Cernunnos, Anubis, Odin, Osiris, and Hecate to name a few.

Colors: Red, yellow, orange, most warm colors, black

Herbs: Mugwort, Cinnamon, Nutmeg, Allspice, sandalwood, and dragon's blood.

Stones and Metals: Onyx, obsidian, tiger's eye, smoky quartz, ruby, copper, brass, Jet, black stones in general, darker red stones, etc.

Of course this is a list of the most common associations. If you have an item or god that you associate with the holiday you are more than welcome to celebrate with them! I am not one to gatekeep a holiday. :)

Let me know if you have any questions, comments, or concerns!

[w-tips]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost+-+Sem+ttulo++Tumblr

[pinkbeargladiator]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost

[blogtips]

O Despertador que se Atrasou – Ebook e Vídeo Animação https://wednesdaystips.com/o-despertador-que-se-atrasou-ebook-e-animacao/?utm_source=tumblr&utm_medium=social&utm_campaign=ReviveOldPost

[harepare]

nur beni telefonuna kaydetmis suan ya kalbim gotume dustu ya da gotum kalbime dogru kalkti bilmiyorum ay tovbe estagfurullah kimyacida test wtip duruyo dovcem

[wednesdaystips]

Por que a Coreia do Sul tem as maiores taxas de suicídio entre os países desenvolvidos - Trends WTips

[spaceaqueerious]

just listing all my tags so i can stay organized~

misc > gen

vibes (moved to sideblog @.spacey-board)

motive

tv

steven universe

games

the arcana

qdemar - miscellaneous things that make me think of valdemar :’)

the arcana lore

stardew valley

code vein

mass effect

ace attorney

anime

manga

txt post

asks

next day reblog > next day rb

my fics

my art

my ocs

sa: gemini klim

nm ocs

fave

save - other stuff

ref - art-related/to take action on

prompts

archive - review later

nsft > ns

oott

orb

wtips

aposting

sq (forgot the actual tag I made for this so here)