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bubblyhoney · 3 years

Note

can i request a fic where sapnap takes the reader to his hometown? like the classic going to places he went to when he was younger. maybe playgrounds and ice cream shops idk

places i used to go

warnings: language of course, an allusion to virginap, my uneducated guess of what sapnap was like in highschool, tiny detail of long haired!sapnap, singular canon detail of underage drinking, jokish about marriage

tags: sapnap x gn!reader

words: 2191

A/N: you are a god, anon. i love comfy and nostalgic fics like these and it was so fun to write. if you hate it dont tell me but if you like it lemme know akskdjd

inbox/requests: open

The wind whips fast on your bare fingers, cool and quick and raising goosebumps in its wake. You blink in the haze of the early sunset, head lolled to the side of the headrest. It feels good.

“That’s where I went to high school.” Sapnap interrupts your thoughts and points a finger at a collection of tall brick buildings down a side street. The silver of the lettering is dull, but you can still feel the nostalgia.

“And you’re about to see the park that me and my friends used to hang out at after work and—actually, nevermind.” His arm drops to the middle console and he looks straight ahead with slightly pinker cheeks.

“Do what?” You ask, voice all sweet, and a grin grows on your face. You turn towards him and wiggle your eyebrows.

“Nothing. Homework.” He avoids your eye contact and hikes his hand up higher on the steering wheel. “Anyways— Do you want to get some food before we head out? I know a great place.”

You two were just coming to a close on your little trip to visit his family; it was his step-mom’s birthday and you decided to make a week of it. It was your first long-term trip with Sapnap, and also your first time meeting his dad’s side of the family. You were proud to say she loved you. His little sister took a little more effort to talk to you of her own volition, but soon enough she was on your side.

You have a couple hours to kill before making your flight back home, so Sapnap has taken it upon himself to give you a quick tour of his hometown.

“Yeah,” you decide, bottom lip popped out. “Can we get ice cream after?”

“Uh, duh.” The Neighbourhood’s Stargazing starts through the speakers and he reaches to turn it down. “I’m so ready to get home and sleep.” He stretches his neck in his seat, letting out an uncharacteristically inappropriate grunt when his bones pop. You make a disgusted face, nose wrinkling, but stretch your own back, slumping down in the seat. The day had been full of packing up and this horrible hike his dad liked to do early in the mornings, so you two were pretty beat.

“Okay, we’re here,” he announces three sleepy minutes later in his best attempt at a whisper. Lifting your head off of the corner of your seat, you blink in the setting sunlight as a yawn splits your face. “You’re so cute.”

“Shut up,” you mumble, and struggle to get your seatbelt off in that post-nap haze. You’d barely been asleep for thirty seconds, damn it. The air is a swampy heat when you step out of the car onto rocky gravel and nearly twist your ankle climbing over the curb. Sapnap catches you by the lower back, trying to hide his laugh but failing miserably. You slide him a dirty look, smacking his shoulder as hard as you can manage while limping towards the front entrance.

The door jingles when you two breach the doorway, alerting a bored-looking hostess that the circus has arrived. She looks at Sapnap a second longer than she should, eyebrows screwed together in silent confusion. But she leads the two of you to a booth near a large window, handing you sticky menus and promptly fucking right off to the host station. She nearly runs.

“Do you know her?” You ask, inconspicuously hiding your face in the search for their 24/7 breakfast menu. You feel his eyes on you.

“Don’t think so.” He leans on one elbow and slides his phone out of his jeans’ pocket. In the 25 seconds it takes for you to find their french toast and sides menu, he has browsed and closed his phone with an animatedly shocked look on his face.

“What?” You give him a weird look and put down the menu.

“I totally went to homecoming with that girl.” He eyes the hostess. You glance over at her again, meeting her gaze, and offer a polite smile. She turns away quickly, eyes wide.

“She’s cute,” you say, voice high and fake, and he drums his fingers on the tabletop as an amused look makes its way onto his face.

“Are you—?”

“What?” You reply right back.

“Nothing.”

Thank God the server comes up to your table then and starts asking for drink orders, or else you’d have to admit (sheepishly) you were a tiny eensy-weensy bit annoyed. Only a tad. But after requesting a Dr. Pepper and a water the conversation surrounding the nervous-looking hostess dies.

“I’m so hungry I think I feel my stomach shrinking.” You flop your head onto your arm on the table top and make a whiny noise into the stack of napkins your server left at the table. Sapnap rubs his thumb into the side of your forearm, touch warm and nearly dissolving the pangs of hunger and jealousy.

“You weren’t hungry an hour ago.” He lifts your hand to his face and plants a kiss on the back of it. Oh, pulling out the big guns, huh? “I would have made you something.”

You tilt onto your chin, pouting, and stare up at his cute face. His cute, scruffy, perfectly-kissable face.

“I think I got hungry staring at you for half an hour.” A mischievous grin grows on your previously-petulant face and he just shakes his head.

“I do have that effect,” he admits with cockiness in his tone, lifting his eyebrows and leaning back into the booth with his lips pursed.

The server returns with two glasses and takes your food orders onto their little yellow notepad. You chug the water down when they leave for the kitchen, getting your lap and chin thoroughly wet in the process. Sapnap just snorts at you and shoves the napkins your way.

“So,” you start, patting dry your jeans. “tell me what you were like in high school.” You cross your arms and settle into the booth, smirk on your lips.

“What I was like?” He parrots, sipping at his soda, looking thoughtful. “Firstly, a virgin.” You make a noise. Duh. Dude had a buzz cut his junior year. (You’ve seen the pictures. His step-mom particularly likes them.) “Secondly, I was actually— well, I wasn’t popular, but I had a lot of friends. We were all semi-athletic lonely band kids but we had fun. Had one girlfriend senior year but she went to Cal Tech in the fall and I didn’t. I, um, worked at a Dairy Queen in the summers and gained so much weight I had to lose all over again for Unified Track.”

“Relatable,” you comment, drinking noisily at your water. He fiddles with the paper straw wrapper and crunches it up into a ball. It goes soaring into your drink with a quiet “Kobe” and you just give him a look. He smiles toothily right back at you. “Stop being cute, I’m trying to listen to your story.”

“Oh, my bad,” he mocks. “Anyways. That’s what I was like in highschool.” You fish the paper ball out of your water and flick it wetly at his arm. It sticks and you choke on a laugh, cheeks puffed.

Two plates of warm food are set down loudly onto the table and you thank the server with a surprised smile, Sapnap mirroring you.

Two minutes of wordless chewing passes, minds occupied just by “food, me eat” instead of anything related to your previous conversation. You realize that Sapnap is one of the loudest chewers ever, and he realizes that you fail to notice the streak of maple syrup in your hair.

“C’mere,” he mumbles through a mouthful of omelet and hash browns and beckons you with his hand. You lean closer, chewing slowly, as he pats a napkin at the strands of hair trapped in syrup.

“Thanks, baby.” You take the napkin from him and pause your assault of the warm french toast before you to clean the sticky sugar out of your hair. He just watches you, half of a smile on his lips.

You two finish your food in record time. It’s borderline vacuum-like. There’s a short grace period where you just sit like two lazy cats, slumped down in the booth and holding your full stomachs. But the check comes soon after, and you both pay your way and are out of the restaurant without any mad dashes for the bathroom. A miracle, really, because of the American-like amount of butter you both consume.

“I’m a much more functional person now,” you mutter into the cotton of his shoulder, swinging your hand in his. He just hums in agreement.

“I guess we’re not getting ice cream, then,” he teases, and you just groan in response.

“I don’t feel like having diarrhea on a plane, unfortunately.” You sigh heavily when you have to split and get into your respective sides of the rental car.

The entire trip (somewhat roundabout because of the amount of side quests to show you things from his childhood) to the airport Sapnap is a chatterbox. He’s like this when he has sugar: either bouncing off the walls with energy or talking your ear off.

“That’s where my dad proposed to my step-mom. I was kinda young but I remember being surprised at how big the ring was— dude broke the bank for her.” It’s a little gazebo you catch a glimpse of through the trees in a park. It probably was an incredibly picturesque moment, and you can sense how much she must have loved it. With just meeting them this weekend, you can already see how much love those two have for each other.

You hope people can see how much you love Sapnap.

“Oh my God, it’s still there.” He points out the side of your window to what looks like a Dairy Queen that has been through World War 3. “My buddy Eric and I once spilled a gallon of that liquid ice-cream-shit all over the men’s bathroom.”

You shoot him a horrified look. “Why was it in the bathroom?”

He just smirks.

“—And that’s my Uncle Ron’s house. Had my first beer there.”

“And last, hopefully,” you add, pulling a disgusted face. The two story bungalow is cute, and one of your favorite colors: olive green. “That shit is nasty.”

He just shrugs and continues down the side street.

“Is this the park you were talking about?”

He pulls into the gravelly parking lot of a small clearing of tall trees, a picnic table and campfire sat squat in the middle. But he doesn’t respond, just turning the car off and climbing out. He reaches the passenger door without speaking, and opens it for you. You climb carefully out, confused.

“Come on.” He takes your hand and starts for a small path to the left of the picnic table. The mid-sunset shade envelopes the both of you.

“I hope this isn’t where you kill me.”

“No,” he snorts. “I just wanted to show you something.”

It’s just a few moments of stumbling through the damp underbrush before you’re coming face to face with a small, mossy pond that sits right underneath an incredibly old willow tree. He stops right on the edge of the rocky path and turns toward you.

“This your make out spot?” You ask between a grin as he snakes an arm around your waist and tugs you flush to him. Your innocent smile fades when you feel the press of his lips to the side of your neck, light and ticklish. Oh.

“No,” he murmurs, and just breathes you in. “I came here once—the night before I graduated highschool. And I told myself when I really really loved someone I’d take them here with me.” He sways with you in his grasp, a gentle and song-less dance.

You grip his shoulder tighter in your hand and lean into him.

“That’s— awfully romantic, huh?” Your voice is quiet. Almost nervous. He just makes a noise of agreement.

“So here we are.” His voice is the opposite of yours, all strong and confident.

You two just move together for a moment. The sun breaks through the tree canopy, shining bright orange down onto the glassy surface of the pond. Crickets and frogs chirp back and forth as the willow vines swing in a cool evening breeze. You watch nature come alive around you, suddenly grateful for the man in your arms.

“Don’t propose,” you whisper, breaking the gentle tension. A laugh breaks the silence and he’s pulling away to look at you. Maybe in disbelief. A strand of hair falls into his eyes and you brush it away, fingers stilling on his temple and sliding down onto his cheek. Stubble scrapes against the skin of your palm and he stares at you through those meadow eyes.

You realize in that moment that he is exactly himself. Of course he is. He’s Sapnap, and everything that encompasses that. Dark and light and fiery and cool. He always has been, and always will be.

You realize you wouldn’t mind if he proposed.

A/N: ask or send me some stuff!! requests, rants, anything. let me know what you think

#sapnap #mcyt #sapnap x gn!reader #sapnap x reader #sapnap x you #sapnap fluff #sapnap drabble #sapnap one shot #sapnap oneshot #mcyt x reader #mcyt x you #honey answers #my lovely anon #sapnap fanfic #bubblyhoneyfics

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ugh-againwiththenames · 3 years

Text

So Many Fanfics So Little Time

This is just my list, I have seen so many (but if you want to use it it’s all yours too!). I’m not a writer. But I am a hell of a reader. Voracious one might argue. I just wanted to track my progress through the weeds of the absolutely never ending supply of Destiel and Cockles fanfic.

Read on if you want to see what I’ve read, and what I’ve thought. I am but one person with opinions - some of them may be unpopular - some of them you might agree with, but if you find something you haven’t read here, I encourage you to do so.

Honestly, this is just so I can track what I have read already, and when my friends ask, I can reference something easily. I have found some different fics on all kinds of ‘best of’ lists all over the interwebs. And I love recs - so rec away friends.

As someone who reads a solid 40 novels a year typically, I don’t come by the “I read a lot” innocently. I do actually read a LOT. When not reading fanfic (a new obsession, all things being fair), I usually read a lot of Fantasy/high fantasy, romance/erotica, and or YA (yeah, that was a bit of a ride no?). So from this one might digress that I like fluffy, cute stories, complicated and supernatural/paranormal type stories, and I sure do not shy away from violence or smut (or maybe violence with smut? *smirk*).

I have read all of these in the last 2-3 months (I will continue to add as I go). I had never read a fanfic until 2-3 months ago. A lot of these wonderful people are on here, and I mean you no offence by not directly tagging you - I’m still learning how to actually properly use this site. Links to AO3 are included (and I love you all).

These aren’t necessarily in any real order - I did read T&S first, followed by 91W, and 4LW...after that it’s just a shit show of Long or Short, Destiel or Cockles - smorgasbord. Some of these are the most popular Fics out there, and others I’ve never seen recc’d anywhere (just sort of accidentally happened upon them). So let’s get to it, shall we?

Twist and Shout - ok look. I understand the stigma associated with this one, but it was the FIRST one I read. It was the ball that shot me down the hill, and I haven’t stopped since. So. I loved it. I CRIED like a baby. SOBBED. It was not the quality of the writing but the way the story was developed and delivered. I have Never Cried Like This Reading a Story IN MY LIFE. It’s a rite of passage. Read It and have an opinion - it doesn’t need to be mine.

Author(s): gabriel, standbyme https://archiveofourown.org/works/537876/chapters/955188

Ninety-One Whiskey - aka 91W, it is mentioned so much, and is SO worth the read. I continued my dive into the war fics (not typically my bag really and here I was reading 2 in a row). There are a couple of followup stories as well to this series (and yes, I’ve read them all). Although I’ll say that the original is my favourite. I often got lost in a bit of the War/Tactical descriptions, but would recommend it to anyone anyway. Ugh...the “stolen moments”...they were at the same time tragic and the most amazing things ever. You feel me? no? go read it.

Author: komodobits https://archiveofourown.org/works/2362190/chapters/5214500

Four Letter Word for Intercourse - aka 4LW. OMG just, OMG. I loved this story. I loved it so much. I think I read it in a day. Devoured it. It’s so HOT. Just read it. If you haven’t you’re missing out. LEMME AT IT. I loved “knowing the secret”, and had some major anxiety about that realization dawning (I had to take a breath, and be like, no, no, this is gonna be a mess, but it’s gonna be SO GOOD - I was not disappointed). There’s more than one work here too - read them all. PLEASE.

Author: bendingsignpost https://archiveofourown.org/works/16086839/chapters/37568591

Memories Bring Back Memories (Bring Back You) - This was the first Sobs one I read, but it sent me on a spree. this is the Memory Loss one. I have one piece of advice here - read everything by Sobsicles. You can thank me later...just go to her page, and fucking sort to supernatural (or not, read it all!) I’d list them but I’d fucking seriously be here all day. Also, her tags make me laugh so hard.

Author: sobsicles https://archiveofourown.org/works/24022945/chapters/57796885

Orpheus - I love this one too, Tattooed!Cas, my LOVE. paired with Mechanic!Dean, my HEART, #help. Read this one in one evening as well. (I was on a roll). It’s a one night stand that turns into more (much like my last relationship)....hmm...maybe this is why I was pulled in - although to be fair that is the last similarity to my shitty love life! I do not remember how I stumbled onto this one (tattooed Cas may have been the draw...tbh). Read the warnings though, there is some triggering stuff in this one - but if you can handle it, it’s definitely worth the read.

Author: sysrae https://archiveofourown.org/works/2364347/chapters/5220227

Have Love, Will Travel - Can you say no to Stripper!Dean? Cause I sure as hell cannot. Typical sort of character development here with Dean having trust issues, and Cas being painfully awkward...(but in like a super cute way?). Would Recommend.

Author: squeemonster https://archiveofourown.org/works/565455/chapters/1011747

The Inexhaustible Silence of Houses - Change of pace here...It’s got a nice twist. I didn’t actually clue into how it was going to end until very near the end (maybe I was being oblivious), when the realization came over me and I was...man. I was DONE IN. I hope that doesn’t spoil (I need some kind of way of remembering them). Voiceless!Cas Hunter!Dean

Author: Askance (doomcountry) https://archiveofourown.org/works/560268/chapters/1000755

Adagio - This is super short, and super cute. Honestly, I would read the whole thing just for the last line. It’ll take you less than an hour if I remember correctly. Go, I’ll wait. I squeeed. did you?

Author: noangelsinthegarrison https://archiveofourown.org/works/1397248/chapters/2928145

Any Little Heartache - super easy read (not in a bad way, but in a ‘you’ll fly through it’ way). It’s mid-length, not graphic, but really fun hospital AU. HeartSurgeon!Dean / Nurse!Cas - enemies to lovers anyone? Fuck you to Fuck me? yeah. YUM.

Author: followthattardis https://archiveofourown.org/works/5143376/chapters/11838311

Ad Astra - This is another short(ish) one, just one chapter. And by that I mean that this is written like a very long poem. Cas as a star who has visited Dean many times over the years of his life, that culminates in 4x01 barn scene. It’s ‘awe’ sad. ‘puppy dog eyes’ sad. The writing format took me a bit to understand what was happening - it’s my lack of poetry knowledge, not the writing.

Author: nhixxie https://archiveofourown.org/works/1013491

Ad Astra Per Aspera - This is a cute story. ESL writer, no judgement. I found this while looking for the one above, and thought the premise looked cute - and it was. Misunderstanding leading to Dean realizing he’s actually Bi. Miscommunication leading to realization.

Author: Riverchester https://archiveofourown.org/works/12354336/chapters/28101816

Psalm 40:2 - Time travel post-canon Cas and Pre-series Dean. If you’re wondering how that works, strap in for this ride, it’s well worth it.

Author: unicornpoe https://archiveofourown.org/works/30786425/chapters/75992444

Addicted to You - Warlock!Dean/Incubus!Cas - accidental ‘mating’ (I actually really don’t like that word, but there’s sort of no avoiding it in this situation). Cute story. When you drunk dial a succubus and get an incubus instead...Whatever will we do?

Author: Ltleflrt https://archiveofourown.org/works/4387346/chapters/9959288

A Glimpse Beyond - End Fix-it. Not yet complete, 10 chapters so far...I want MORE! Reliving memories Dean/Cas & Sam/Eileen.

Author: NorthernSparrow https://archiveofourown.org/works/27731689/chapters/67875925

Cas-ti-el - Please I want more...It’s like the story just started. Please write more of this story!! 1 chapter, it’s a trope prompt challenge, but I want it to be a full on story of its own. Imprinted names of their soul mates, Dean doesn’t understand his (because it’s in a different language)...I’m frustrated by wanting this story to keep going.

Author: Valinde (Valyria) https://archiveofourown.org/works/1941591

Our Bodies, Posessed by Light - another short one. Not going to lie, this one took a little getting used to, and I can’t say that I enjoyed it too much for the sole purpose that the premise gave me the willies. Cas has to vessel jump - ends up in Sam...I got through it, it had a good ending, but yeah, sorry. This just wasn’t for me.

Author: obstinatrix https://archiveofourown.org/works/260289

Peanut Butter Pumpkin Wedding Cake - Waiter!Dean / Writer!Cas - This is so effing cute, just misunderstanding after misunderstanding bumbling around like the couple of dorks that they are. It’s only one chapter. 100% would recommend.

Author: Sparseparsley https://archiveofourown.org/works/223962

Destiel, Actually - This is another super cute story, 5 chapters. Gabriel playing a singular role in putting Dean and Cas in awkward positions to push them together. I fucking DIED at “oh, I am the sub” - needs context, but I guarantee you that you’ll laugh out loud...

Author: Bexism https://archiveofourown.org/works/399934/chapters/658398

The Smell Before the Rain - This was my first A/B/O - a big apology to all those who are into mpreg and whatnot, this was my lesson that I am not. this was not for me. Also - I’m a firm Cas (Alpha/Dom) believer, and i’m good with switch Cas, but it’s hard for me to take him being the full Omega here, when paired with the rest I just couldn’t do it. I finished it, but, not my thing. I know now.

Author: jscribbles https://archiveofourown.org/works/22355230/chapters/53406127

Crazy Diamonds - This is another short one, only 3 chapters - it’s a body swap for Dean, 4x02 him and 2018 him swap places (assumption that 2018 him is “with” Cas). It’s a super cute little story.

Author: pantheon_of_discord https://archiveofourown.org/works/16151642/chapters/37738631

The Breath of All Things - Wheelchair!Dean / Volunteer!Cas. This is a lovely story, typical Dean self-hatred etc. Triggering for those with suicide warnings. It had me in tears at the end. There’s a really spectacular quote near the end that I found so romantic I screen grabbed it.

Author: KismetJeska https://archiveofourown.org/works/994750/chapters/1967519

Kind of a Forever Deal - SummerCamp!AU This is just a really cute and fluffy summer camp AU. Which is so different from 91W (That’s right, check the author)! I was a little disappointed with the ending, but otherwise really enjoyed this all the way through and was loving all the discovery and young characterizations of all the characters.

Author: komodobits https://archiveofourown.org/works/999291/chapters/1978478

Everytown, USA - Best way I can break this one down? Wanderer!Dean (listless and without a place in the world, he ends up in a small town...), Twin!Cas (that leads to some fun things). There are a number of points where you’re gonna yell at Dean for doing stupid shit (that are very much in character for him to do), you think, well, yes, obviously you’re going to do that you silly fucking boy [affectionate]; but whyyy? (but we know).

Author: aileenrose https://archiveofourown.org/works/1797559/chapters/3854836

Chalk and Chainmail - HighSchool!AU, Cas is an artist, Dean LARP’s - it’s cute and angsty.

Author: lemonsorbae https://archiveofourown.org/works/804704/chapters/1517551

A Little Patience - Ok. you want smut? This is your story. You want Kink? This is your story. I actually did not finish this. It got a little carried away in my opinion. It was VERY panty kink oriented (which, while essentially canon isn’t really my kink) so, if you want that Panty Kink on full display? Go forth and enjoy! it is thirty something chapters, I got to the mid-twenties I Think.

Author: riseofthefallenone https://archiveofourown.org/works/1750058/chapters/3739232

Control - I REALLY ENJOYED THIS. Which is saying a lot for someone who has already admitted that a Subby Cas isn’t really my HC - so to so thoroughly enjoy a Sub!Cas story? (maybe it’s the tattooes...*wink*). It’s an AU where Cas is the head of a company - Dean is a callboy I guess, for lack of a better term. Just read it.

Author: dothraki_shieldmaiden https://archiveofourown.org/works/31156601/chapters/76993217

More (I copy pasted the next lot from my google doc, I’ll flush them out later - no i wont...)

Teach Me (short) - movie night in the bunker, things get a little carried away Author: Chiyume https://archiveofourown.org/works/5961327

You Light the Spark (in my bonfire heart) (short) - when cas doesn't realize that dean is unaware of his feelings, super short, super cute Author: noangelsinthegarrison https://archiveofourown.org/works/1193910

Communication Breakdown (short/cockles) - dean ends up in Jensen's head while he films the confession scene, no sexual content Author: jujubiest https://archiveofourown.org/works/29669601/chapters/72951339

Look What You Made Me Do (short/cockles) - - Vegas Con 2020 / jensen comes out with a song - cute short - no sexual content Author: green_blue_heller https://archiveofourown.org/works/30251592 Full House (short/cockles) - reimagined version of the rented house story - putting it in order (so to speak). funny / cute / fluffy not explicit Author: n_nami https://archiveofourown.org/works/30855827

Cyber Sex (short/cockles) - anastiel https://archiveofourown.org/works/31467086 - shameless post GISH Fest zoom call porn - Short (very short)

It's Complicated (cockles) - gail_morgan https://archiveofourown.org/works/31434938/chapters/77747519 The GISHtake (short/cockles) - MellyCrazyCoconut https://archiveofourown.org/works/31508099 - cute short post GISH zoom - oops "babe, really?"

(10.02.2021 updated) Since last update: New reads - Fuck i’m gonna be here all day - there’s not gonna be as much gonna be NO detail in these breakdowns...sorry! This has now just become a “what i’ve read list” as opposed to a Rec list...

Love, All Alike (Pt. 1 Love, All Alike) - Phantoms_and_Foxgloves https://archiveofourown.org/works/4555599/chapters/10370646 - Though The Stars Walk Backward (pt 2 Love, All alike) - Phantoms_and_Foxgloves

And this, your living kiss - opal_bullets https://archiveofourown.org/works/18083927/chapters/42744872

Come On, Let's Strike a Match (Domination and Submission: a love story pt 1) - anyrei & queerwerewolf *** https://archiveofourown.org/works/25722478/chapters/62458810 - Playing With Fire (D&S: a love story pt 2) - We Kiss and the Flames Get Higher (D&S: a love story pt 3) - Sparking That Old Flame (D&S: a love story pt 4)

Cinderwings - bendingsignpost Cinderella!AU** https://archiveofourown.org/works/12847041/chapters/29336421

Linden - fleeceframe Swan!AU** https://archiveofourown.org/works/33126730/chapters/82236118

No Netflix, No Chill (short) - dorian_they https://archiveofourown.org/works/28764966

Can't Drink You Away (short) - dorian_they https://archiveofourown.org/works/28785792

Jensen Totally (Does Not!) Snore (short RPF) - Dorian_they https://archiveofourown.org/works/30315717

Dean Ships It (short) - dorian_they https://archiveofourown.org/works/30349434

All about control - wingless https://archiveofourown.org/works/9151930/chapters/20791243

Aesthetics in Autoerotica (pt 1 Aesthetics in Autoerotica) - relucant https://archiveofourown.org/works/3885544 - The Ties that Bind (pt 2 Aesthetics in Autoerotica) - relucant

Let's take a drive - sobsicles https://archiveofourown.org/works/32581027/chapters/80819581

Enchanted ink - castielslostwings TattooArtist!Dean TattooArtist!Castiel AU *** https://archiveofourown.org/works/23043622/chapters/55109530

The bones beneath our skin - darknessbound https://archiveofourown.org/works/24633754/chapters/59515804

The Plot (RPF) - Castiel_Left_His_Mark_On_Me https://archiveofourown.org/works/2795588/chapters/6274970

The Gentle Force with which you Take Me (RPF) - Phoenix_Ascended https://archiveofourown.org/works/32110120/chapters/79549183

According to all known laws of Life (Pt. 1 Cursed Metaphors) - sobsicles https://archiveofourown.org/works/29207901 - and he's back (with a mind of his own) (pt. 2 Cursed Metaphors) - sobsicles

Six hundred sundays (and many more) - sobsicles https://archiveofourown.org/works/31158776

Aching in the Absence of you - sobsicles https://archiveofourown.org/works/31832977/chapters/78811378

gorging myself on you, still can’t get full (insatiable) (Short) - sobsicles https://archiveofourown.org/works/32203291

memories bring back memories (bring back you) - sobsicles https://archiveofourown.org/works/24022945/chapters/57796885

Dream Come True (short) - bendingsignpost https://archiveofourown.org/works/28071159

tall grass - aeli_kindara https://archiveofourown.org/works/13127040/chapters/30030726

asunder (Short) - rageprufrock https://archiveofourown.org/works/62115

Apheresis - bendingsignpost BloodDonor!AU ** https://archiveofourown.org/works/32674783/chapters/81056680

we always were but never knew it - frightfullyrude https://archiveofourown.org/works/32698324/chapters/81119503

In this Louisiana Bar (Short) - fleeceframe https://archiveofourown.org/works/31764487

The Hitchhiker's Guide to Alternate Universes - n_nami https://archiveofourown.org/works/32687929/chapters/81092785

my heart a compass - lagaudiere https://archiveofourown.org/works/28629951

Unsound Inverses - sp8ce (not complete) https://archiveofourown.org/works/29836881/chapters/73413300

The Jensen Mistake (RPFish) - fellshish https://archiveofourown.org/works/31950169

tell me about the dream (Pt. 1 Kids are coming home) - playedwright https://archiveofourown.org/works/27984813/chapters/68544450

It's handy to know (FIMMF Themed ;)) - RosaMarloes https://archiveofourown.org/works/31761322

So Says The Sword - komodobits AngelTrueform!AU** https://archiveofourown.org/works/12597892/chapters/28695592

Communication Breakdown (RPFish)- darkshrimpemotions (jujubiest) https://archiveofourown.org/works/29669601/chapters/72951339

Carry You Home - Casloveshisfreckles https://archiveofourown.org/works/26982637/chapters/65862916

In the Shadow of your Wings - Enochian Things (Salr323) https://archiveofourown.org/works/7531294/chapters/17121655

When Harry Met Sally (RPF) (Pt. 1 When Harry Met Sally ‘verse) - mnwood https://archiveofourown.org/works/7622347/chapters/17351845 - Eight Dildos (RPF) (Pt. 2 When Harry Met Sally ‘verse) - mnwood - Attention, Please (RPF) (Pt. 3 When Harry Met Sally ‘verse) - mnwood - Boat Trip (RPF) (Pt. 4 When Harry Met Sally ‘verse) - mnwood

A Winter's Tale - NorthernSparrow https://archiveofourown.org/works/2654327/chapters/5930561

A Close Shave - NorthernSparrow https://archiveofourown.org/works/3090167

r/supernatural - renrub (short) https://archiveofourown.org/works/27626783

sam reads destiel fics - rebshome (short - funny!) https://archiveofourown.org/works/33721624

Angel Cookies - noxsoulmate Chirstmas!AU ** https://archiveofourown.org/works/11729640/chapters/26427765

Under The Midnight Sun - NorthernSparrow Arctic!AU ** https://archiveofourown.org/works/16690645/chapters/39143677

Bron-Yr-Aur - mrbluesky (Short) https://archiveofourown.org/works/28225335

The Dean Winchester Beat Sheet - saltyfeathers https://archiveofourown.org/works/19258594/chapters/45800209

The Meaning On My Skin - saltnhalo https://archiveofourown.org/works/18005378/chapters/42538133

Red Right Hand (Pt. 1 Murder Ballads) - Duckyboos https://archiveofourown.org/works/4306110/chapters/9760008 - Are you the One that I've been waiting for? (pt. 2 Murder Ballads) - Duckyboos

Riptides - sharkfish https://archiveofourown.org/works/13230426/chapters/30263556

Damn Fine Ride - Cimorene105 (pt 1 - rodeo) Cowboy!AU** (I’m a horse girl, sue me...) https://archiveofourown.org/works/14342340 - My Face Just Does This, Sometimes - Cimorene105 (pt. 2 rodeo) - The Kinkiest Thing I've Ever Done- Cimorene105 (pt 3 rodeo) - All Signs Point to Love - Cimorene105 (pt. 4 rodeo) - Monster Love - Cimorene105 (pt. 5 rodeo) - My Man, The Siren - Cimorene105 (pt. 6 rodeo) - A Pain in My Ass - Cimorene105 (pt. 7 rodeo)

Astrolabe (terra incognita pt 1) - reluctantabandon, Winter_of_our_Discontent https://archiveofourown.org/works/3348812/chapters/7326794 - Drollery (terra incognita pt 2) - reluctantabandon Winter_of_our_Discontent - Rubrication (terra incognita pt 3) - reluctantabandon Winter_of_our_Discontent

Go Down With This Ship - PorcupineGirl https://archiveofourown.org/works/8023642/chapters/18370474

Fire and Ice - Castielslostwings (Firefighter/Paramedic AU!) ** https://archiveofourown.org/works/23286295/chapters/55768486

The Structural Similarities of Hunters and Onions - Faster_Than_the_Speed_of_Sound (Short) https://archiveofourown.org/works/33383101

Castiel Novak's Office, This is Dean - emmbrancsxx0 https://archiveofourown.org/works/22411336/chapters/53545840

Out of the Deep (out of the deep pt. 1) - riseofthefallenone - MERMAID AU! ** https://archiveofourown.org/works/548878/chapters/977676

Dean (and Cas') Top 13 Zepp Traxx - pantheon_of_discord https://archiveofourown.org/works/10909440/chapters/24256989

I'll Be Good - LittleAngelCassie https://archiveofourown.org/works/4118334/chapters/9282234

Kenosis - CastielsCarma (Short - part of Destiel ABC collection) https://archiveofourown.org/works/30411720

#fics #fic recs #fanfiction #ao3 #cockles #destiel #dean and cas #jensen and misha #one track mind #supernatural #please send me recs #read more fics #this is my new obsession

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theliqht · 5 years

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Why You Should Spend More Time Thinking About best portable keyboard

How are they undertaking this?

They're accessing MOOCs, or Massive Open On the internet Courses. Although platforms have been readily available from elite colleges like MIT and Stanford for nearly ten years, open up-source classes keep on to expand in number and popularity. Now, even some local community colleges like Wake Technical School,Positioned outside Raleigh, NC, gives MOOCs to a world viewers. This increasing availability usually means You can find now an incredible a number of programs accessible to any individual with an Connection to the internet, regardless of spot.

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Motives to think about a MOOC

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If learning A further language isn't higher on the to-do listing, possibly it should be: In 2017, New American Economic climate documented employer demand for bilingual personnel a lot more than doubled due to the fact 2010. This need carries on to develop. Most effective languages to review? Spanish, Chinese, and Arabic.

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Keep to the links in the following paragraphs For more info on lots of MOOC courses. MOOCs are also offered by means of several different academic platforms, which includes Coursera, Udemy, and edX. But MOOCs can be accessed directly by means of Just about every university, and can be found through the use of the next Google search limiting syntax entered into your google search bar:

web page:edu MOOC topic

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Joyful MOOCing!

"Millennials," "Era Y," "The Peter Pan Technology" - they go by many names and had been born roughly between 1980 and 2000.They can be the technology that grew up with smartphones, rear-dealing with cameras, internet etc. They had been at a tender and vulnerable age when Harry Potter to start with took his traveling classes on his magical broom, if they witnessed the great fall of the dual Towers of Globe Trade Centre in Ny city on 9/11. The millennials grew up during the period of mobile phones, digital cameras, electronic mail, text-messaging, mp3 gamers, handheld movie game products, WhatsApp, Facebook/Instagram, YouTube Films, web browsing and what not.

A person this kind of millennial who knocked my socks off was this young girl named Anushka, a teenager in her early twenties. Her white t-shirt with "MILLENNIAL" in large, black, Daring letters just caught our speedy interest and we couldn't halt thinking of her Special Expertise Presentation, below at Nirmiti Academy. The Do-it-yourself (Do It Oneself) Craft was her one of a kind talent. She represented a young confront of the millennials. Additionally, it was her presentation that spoke extra of her like a millennial. She was a real go-getter when it came to current her exceptional talent in a singular way. We could see her beaming with delight and happiness to showcase her exceptional talent to Other people. She was so thrilled that she was talking a mile a minute. She had a great deal to mention about this and she could go on and on and retain us glued to her presentation. The millennials like Anushka and a lot of Many others are enthusiastic to work on points which desire them. Concurrently, I could also see her remaining not able to smile and present herself Fortunately. Long gone will be the times for your millennials wherever they come to feel present and luxuriate in their surroundings. These are the technology who experience the regular need for virtual notice which potential customers them to overshare their life and moments on social websites or go inward in deep conscience to find themselves. This leaves them unconnected Using the Bodily entire world about them.

Millennials really are a highly praised and confident technology. These are a hugely optimistic era. They may have a increased will need to possess life encounters in lieu of to accumulate substance wealth, Regardless that they do like to obtain things which can help them to take pleasure in those ordeals. Millennials are the most educated era. Since the value tag of education and learning is now so higher and continuing to climb each and every year, Millennials have grown to be extremely savvy about their academic options. Unlike prior generations who noticed education being a ritual and an investment decision inside their long run, millennials check out training as an price, Until it is going to empower them in an effort to be an even better personal. They hope schooling to help them get ready for The brand new possibilities and challenges of this age, rather then supporting them by providing truth-based data/knowledge. The millennials wish to be challenged by serious about the longer term And exactly how they could add to developing a better Culture and environment. They do not feel the need to come to be "textbook good / reserve worms".

They are aware that points is usually effortlessly located on the internet by way of their very own unbiased action. They can be the technology that offers and prosper on information at finger "click on". In a very planet of open up usage of understanding, it can make little feeling to depend on the classroom being a Discussion board for that transfer of knowledge.

Rather, the students Considerably choose to understand from your stories and experiences of Other people. These shared tales and encounters aid them to enhance their own individual expertise by Studying within the success and issues of Some others. This assists them steer clear of building exactly the same mistakes as their influencers. That's why, they like to invest extra of their time and money on such systems which assistance them to create several techniques that they may include into their thoughts and decision-earning process, therefore developing a new skill set.

We are unable to dismiss The reality that millennials may also be a generation of uncertainties and fluctuations. They may be the technology who likes to maintain switching their gizmos. They grew up with technological know-how in which every thing was at their fingertips. It will become frustrating for them to not get what they need every time they want it. Most of the factors are handed to them over a silver spoon. This helps make them really feel entitled to obtain what they want without Placing in Substantially exertion.

Though These are the foremost workforce of the companies currently, they don't believe in lifelong employment. Lifelong determination is often a fairy tale for that millennials. They always jump from on work to a different as they are constantly in search of some thing new and superior. These large expectations grow to be their downfall and tends to make them significantly less economically stable than their dad and mom.

youtube

Millennials are listed here to stay! They're younger, bright and energetic and they ARE the longer term. They are great property which the world will have to harness and use. They are the generation which is revolutionizing the world. They may be the budding leaders of tomorrow. They undertake know-how and stimulus in precisely the same breadth. This technology can also be a collaborative and social era that features a focus on knowledge and building their information as a result of numerous sorts of medium to find out the answers. It can be for that educator like us to deliver an arena for engagement and discovery together with become a content expert and mentor. It is actually for Mastering System providers like Nirmiti Academy to offer an explorative and experiential experience and bring out their genuine opportunity in life and at work. It is this transformational journey that we at Nirmiti Academy sit up for each day to understand, unlearn and relearn with these youthful and magical technology - the Millennials!

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shuga-hill · 6 years

Link

Life’s Code: Blockchain and the Future of Genomics

In an era of hotly contested debates surrounding data ownership, privacy and monetization, one particular piece of data could be said to be the most personal of all: the human genome.

While we are 99.9 percent identical in our genetic makeup across the species, the remaining 0.1 percent contains unique variations in code that are thought to influence our predisposition toward certain diseases and even our temperamental biases — a blueprint for how susceptible we are to everything from heart disease and Alzheimer’s to jealousy, recklessness and anxiety.

2018 offered ample examples of how bad actors can wreak havoc with nefarious use of even relatively trivial data. For those concerned to protect this most critical form of identity, blockchain has piqued considerable interest as a powerful alternative to the closed architectures and proprietary exploits of the existing genomics data market — promising in their stead a secure and open protocol for life’s code.

Encrypted chains

Sequencing the human genome down to the molecular level of the four ‘letters’ that bind into the double-stranded helices of our DNA was first completed in 2003. The project cost $3.7 billion and 13 years of computing power. Today, it costs $1,000 per unique genome and takes a matter of days. Estimates are that it will soon cost as little as $100.

As genomic data-driven drug design and targeted therapies evolve, pharmaceutical and biotech companies’ interest is expected to catapult the genomics data market in the coming years, with a forecast to hit $27.6 billion by 2025.

If the dataset of your Facebook likes and news feed stupefactions has already been recognized as a major, monetizable asset, the value locked up in your genetic code is increasing exponentially as the revolution in precision medicine and gene editing gathers pace.

Within the past year, unprecedented approvals have been given to new gene therapies in the U.S. One edits cells from a patient's immune system to cure non-Hodgkin lymphoma; another treats a rare, inherited retinal disease that can lead to blindness.

Yet, here’s the rub.

Genomics’ unparalleled potential to trigger a paradigm shift in modern medicine relies on leveraging vast datasets to establish correlations between genetic variants and traits.

Generating the explosion of big genomic data that is still needed to decode the 4-bits of the living organism faces hurdles that are not only scientific, but ethical, social and technological.

For many at the edge of this frontier, this is exactly where Nakamoto��s fabled 2008 white paper — and the technology that would come to be known as blockchain — comes in.

Cointelegraph spoke with three figures from the blockchain genomics space to find out why.

Who owns your genome? Resurrecting the wooly mammoth… and blockchain

For Professor George Church, the world-famous maverick geneticist at Harvard, the boundaries between technologies in and out of the lab are porous. Having co-pioneered direct genome sequencing back in 1984, a short digest of his recent ambitions include attempts to resurrect the long-extinct mammoth, create virus-proof cells and even to reverse aging.

He has now placed another bleeding-edge technology at the center of the genomics revolution: blockchain.

Last year, Church — alongside Harvard colleagues Dennis Grishin and Kamal Obbad — co-founded the blockchain startup Nebula Genomics. Church had been trying for years to accelerate and drive genomic data generation at scale. He had appealed to volunteers to contribute to his nonprofit Personal Genome Project (PGP) — a ‘Wikipedia’ of open-access human genomic data that has aggregated around 10,000 samples so far.

PGP relied on people forfeiting both privacy and ownership in pursuit of advancing science. As Church said in a recent interview, mostly they were either the “particularly altruistic,” or people concerned with accelerating research for a particular disease because of family experiences.

In other cases, as cybersecurity expert DNABits’ Dror Sam Brama told Cointelegraph, it is the patients themselves who generate the data and are “sick enough to throw away any ownership and privacy concerns”:

“The very sick come to the health care system and say, ‘We'll give you anything you want, take it, we’ll sign any paper, consent. Just heal us, find a cure.’”

The challenge is getting everybody else. While no one knows exactly how many people have had their genomes sequenced to date, some estimates suggest it is around one million.

Startups like Nebula and DNABits propose that a tokenized, blockchain-enabled ecosystem could be the technological tipping point for onboarding the masses.

By allowing people to monetize their genomes and sell access directly to data buyers, Nebula thinks its platform could help drive sequencing costs down “to zero or even offer [people] a net profit.”

While Nebula won’t subsidize whole genome sequencing directly, a blockchain model would allow interested buyers — say, two pharmaceutical companies — to pitch in the cash for someone’s sequence in return for access to their data.

Tokenization opens up the flexibility and granular consent for enabling different scenarios. As Brama suggested, a data owner could be entitled to shares in whichever drug might be developed based on the research that they have enabled or be reimbursed for their medical prescription in crypto tokens. Contracts would be published and hashed, and reference to the individual’s consent recorded on the blockchain.

Genomic dystopias

Driving and accelerating data generation is just one part of the equation.

Nebula ran a survey that found that, rather than simply affordability, privacy and ethical concerns eclipsed all other factors when people were asked whether or not they would consider having their genome sequenced. In another study of 13,000 people, 86 percent said they worried about misuse of their genetic data: over half echoed fears about privacy.

These concerns are not simply founded in the dystopian 90s sci-fi of Hollywood — think Gattaca’s biopunk imaginary of a future society in the grips of a neo-eugenics fever.

As Ofer Lidsky — co-founder, CEO and CTO of blockchain genomics startup DNAtix — put it:

“Once your DNA has been compromised, you cannot change it. It’s not like a credit card that you can cancel and receive a new one. Your genetic code is with you for all your life […] Once it’s been compromised, there’s no way back.”

Data is increasingly intercepted, marketized and even weaponized. Sequencing — let alone sharing — your genome is perhaps a step further than many are willing to take, given its singularity, irrevocability and longevity.

DNABits’ Brama gave his cybersecurity take, saying that:

“The consequences are very difficult to imagine, but in a world [in which] people are building carriers like viruses that will spread to cells in the body and edit them — it’s frightening, but in fact, all the building blocks are already there: genome sequencing, breaches of data, gene editing. People are now working to fix major health conditions using gene editing in vivo. But we should assume that every tool out there will eventually also get into the wrong hands.”

He added, “We're not talking about taking advantage of someone just for one night with GHB or some other drug” — this would impact the rest of an individual’s life.

This April, on the heels of the Cambridge Analytica scandal, news broke that police detectives had mined a hobbyists’ genealogy database for fragments of individuals’ DNA they hoped would help solve a murder case that had gone cold for over thirty years.

Law enforcement faced no resistance in accessing a centralized store of genetic material that had been uploaded by an unwitting public. And while many hailed the arrest of the Golden State Killer through a tangle of DNA, others voiced considerable unease.

This obscurity of access has implications beyond forensics. While Brama’s dystopia may be some way off, today there are concerns about genetic discrimination by employers and insurance firms — the latter of which is currently only legally proscribed in a partial way. Grishin echoed this, noting that in the U.S., “you can be denied life insurance because of your DNA.”

This May, the U.S. Federal Trade Commission opened a probe into popular consumer genetic testing firms — including 23andMe and Ancestry.com — over their policies for handling personal and genetic information, and how they share that data with third parties.

23andMe and Ancestry.com represent a recent phenomenon of so-called direct-to-consumer genetic testing, the popularity of which is estimated to have more than doubled last year.

These firms use a narrower technique called genotyping, which identifies 600,000 positions spaced at approximately regular intervals across the 6.4 billion letters of an entire genome. While limited, it still reveals inherently personal genetic information.

The highly popular 23andMe home genotyping kit — sunnily packaged as “Welcome to You” — promises to tell people everything from their ancestral makeup to how likely they are to spend their nights in the fretful clutches of insomnia. The kit comes with a price tag as low as $99.

This July, the world’s sixth largest pharmaceutical company, GlaxoSmithKline (GSK), invested $300 million in a four-year deal to gain access to 23andMe’s database, and the testing firm is estimated to have earned $130 million from selling access to around a million human genotypes, working out at an average price of around $130. By comparison, Facebook reportedly generates around $82 in gross revenue from the data of a single active user.

Battle-proof, anonymized blockchain systems for the genomics revolution

In this increasingly opaque genomics data landscape, private firms monetize the genotypic data spawned by their consumers, and sequence data is fragmented across proprietary, centralized silos — whether in the unwieldy legacy systems of health care and research institutions or in the privately-owned troves of biotech firms.

Bringing genomics onto the blockchain would allow for the circulation that is needed to accelerate research, while protecting this uniquely personal information by keeping anonymized identities separate from cryptographic identifiers. Users remain in control of their data and decide exactly who it gets shared with and for which purposes. That access, in turn, would be tracked on an auditable and immutable ledger.

Grishin outlined Nebula’s version, which would place asymmetric requirements on different members of the ecosystem. Users would have the option to remain anonymous, but a permissioned blockchain system with verified, validator nodes would require data buyers who use the network to be fully transparent about their identity:

“If someone reaches out to you, it shouldn't be just a cryptographic network ID, but it should say this is John Smith from Johnson & Johnson, who works, say, in oncology.”

Grishin added that Nebula has experimented with both Blockstack and the Ethereum(ETH) blockchain but has since decided to move to an in-house prototype, considering the 15 transactions-per-second capacity of Ethereum to be insufficient for its ecosystem.

DNABits’ Brama, also committed to using a permissioned system, proposed using “the simplest and most robust form of blockchain — i.e., a Bitcoin-type network.”

“The more powerful and the more capable engine that you use, the larger the surface attack.”

Lie-proofing the blockchain

23andMe is said to store around five million genotype customer profiles, and rival firm Ancestry.com around 10 million. For each profile, they collect around 300 phenotypic data points — creating surveys that aim to find out how many cigarettes you (think) you’ve smoked during your lifetime or whether yoga or Prozac was more effective in managing your depression.

A phenotype is the set of observable characteristics of an individual that results from the interaction of his or her genotype with their environment. Generating and sharing access to this data is crucial for decoding the genome through a correlation of variants and traits. But as Grishin notes, being largely self-reported, the quality of much of the existing data is uncertain, and a tokenized genomics faces one hurdle in this respect:

“If people will be able to monetize their personal genomic data, then you can imagine that some people might think, ‘If I claim to have a rare condition, many pharma companies will be interested in buying access to my genome’ — which is just not necessarily true. The value of a genome is kind of difficult to predict and it's not correct to say that if you have something rare, then your genome will be more valuable. In fact many studies need a lot of control samples that are kind of just normal.”

Education can help make people aware that they won’t be making any more money by lying and that a middle-of-the-road genome might be just as interesting for a buyer as an unusual one. But Grishin also noted that a blockchain system can offer unique mechanisms that deter deception, even where education fails:

“Blockchain can help to create phenotype surveys that detect incorrect responses or identify where an individual participant has tried to lie. And this can be combined with blockchain-enabled escrow systems, where, for example, before you participate in a survey, you have to deposit a small amount of cryptocurrency in an escrow wallet.”

If conflicting responses indicate that someone has tried to lie about their medical condition, then their deposit could be withheld in a way that is much easier to implement within a blockchain system than compared to one using fiat currencies.

2018: Viruses and chromosomes hit the blockchain

Even with just a fraction of the population on board, given the data-intensivity of the body’s code, a tsunami of sequence is already flooding the existing centralized stores.

The complex, raw dataset of a single genome runs to 200 gigabytes: In June 2017, the U.S. National Institute of Health’s GenBank reportedly contained over two trillion bases of sequence. One of the world’s largest biotech firms, China’s BGI Genomics, announced that same month that it planned to produce five petabases of new DNA in 2017, increasing each year to hit 100 petabases by 2020.

In his interview with Cointelegraph, Lidsky proposed that the raw 200 gigabyte dataset is unnecessary for analysts, emphasizing that initial genome sequencing is read multiple times “say 30 or 100 times,” to mitigate inaccuracies. Once it’s combined, he explained, “the size of the sequence is reduced to 1.5 gigabytes.” This still requires significant compression to bring it to the blockchain. As a reference, the average size of a transaction on the Bitcoin (BTC) blockchain was 423 kilobytes, as of mid-June 2018.

Average transaction size on the Bitcoin blockchain, 2014-18. Source: TradeBlock.com

In June, DNAtix announced the first transfer of a complete chromosome using blockchain technology — specifically IBM’s Hyperledger fabric. Lidsky told Cointelegraph the firm had succeeded in achieving a 99 percent compression rate for DNA this August.

Nebula, for its part, envisions that even on a blockchain, data transfer is unnecessary and ill-advised, given the unique sensitivity of genomics. It proposes sharing data access instead. The solution would combine blockchain with advanced encryption techniques and distributed computing methods. As Grishin outlined:

“Your data can be analyzed locally on your computer by you just running an app on your data yourself […] with additional security measures in place — for example, by using homomorphic encryption to share data in an encrypted form.”

Grishin explained that homomorphic techniques encrypt data but ensure that it is not “nonsensical” — creating “transformations that morph the data without disturbing it”:

“The data buyer doesn't get the underlying data itself but computes on its encrypted form to derive results from it. Code is therefore being moved to the data rather than data being moved to researchers.”

Encrypted data can be made available to developers of so-called genomic apps — something that Nebula, DNAtix and many other emerging startups in the field all propose as one means of providing users with an interpretation of their data. They could also provide a further source of monetization for researchers and other third-party developers.

But is ‘outsourcing’ genomic interpretation to an app that simple? The decades-old health care model referred patients to genetic counselors to go over risks and talk through expectations, helping to translate what can be bewildering and often scary results.

Consumer genetic testing firms have already been accused of leaving their clients “with lots of data and few answers.” Beyond satisfying genealogical curiosity and interpreting a range of ‘wellness’ genes, 23andMe can reveal whether you carry a genetic variant that could impact your child’s future health and has — as of 2017 — even been authorized to disclose genetic health risks, including for breast cancer and Parkinson’s.

Blockchain may not fare much better when it comes to leaving individuals in the dark, faced with the blue glow of their computer screens. Nebula and DNAtix are both considering how to integrate genetic counselors into their ecosystems, and Grishin also proposed that users would be able to “opt in” to whether they really want to “know everything,” or only want “actionable” insights — i.e., things that modern medicine can address.

Blockchain and big pharma

Prescription drug sales globally are forecast to hit $1.2 trillion by 2024. But closing the feedback loop between pharmaceuticals and the millions of people who take their pills each and every day still faces significant hurdles.

Drug development relies on correlating and tracking the life-cycle of medical trials, genetic testing, prescription side effects and longer-term effects relating to lifestyle; tokenization can incentivize individuals and enterprises to share data that is generated across multiple streams. As Brama outlined:

“Lifestyle data comes from wearables, smartphones, smart homes, smart cities, purchasing, commercial interactions, social media, etc. Another is carried by everyone, and that's our genome. The third is clinical and health-condition data generated in the health care system.”

Brama used the analogy of a deck of cards to explain how blockchain could be the key to starting to bring this data into connection, all the while protecting data owners’ anonymity.

An individual can hold an unlimited number of unique addresses in their digital wallet. Going into a pharmacy to purchase a particular drug — say, vitamin C, stamped with a QR code — would generate a transaction for one of these addresses. A visit to a family doctor might generate a further hash for a diagnosis on your electronic medical record (EMR) — say, a runny nose. This transaction goes between the caregiver and another wallet address.

A user might choose to put the correlation between transactions for their different wallets on the blockchain and make it public for people to bid on the underlying data. Or, they might keep the correlation off-chain and send proof only when, say, an insurance firm or research institute advertises to users who have a particular set of transactions:

“You hold the deck. You look at the cards, you decide if you say, if you don't say. And you can put them on the table and let everyone see, or you can indicate privately that you actually have these. It really leaves the choice and the implementation up to you.”

Biotechnological frontiers

Professor Church has made an analogy that likely rings bells for anyone plugged into the crypto and blockchain space, saying that “right now, genome sequencing is like the internet back in the late 1980s. It was there, but no one was using it.”

Blockchain and the vanguard of genomic research have perhaps come closer to each other than ever before. Now that the DNA in our cells is understood as a life-long store of information, a new and disruptive technology is needed to securely and flexibly manage the interlocking networks of the body’s code.

The advent of genomics raises questions that cannot be settled by science alone. For all of our interviewees, blockchain could be just the key to creating the equitable and transparent means of ownership and circulation that would ensure these helices of raw biomaterial don’t spiral out of control.

#health #blockchain #dna

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loumauve · 6 years

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@aimofdestiny tagged me

long ass, rambly response under the cut:

1. Are there any tropes you’d like to see more of in pro fic (aka… traditionally published books)? If so, which ones?

tbh, I haven’t really picked up any books lately. whenever I feel like reading I feel like a v specific set of characters and setup, and fanfic is perfect for that while traditionally published fiction is not.. but ??tropes?? idk. are they all tropes? who ever cares. STUFFS I love include:

COFFEE SHOP/BOOK STORE AUs (geonncannon has some p cool published fiction with similar content; also Ferry Tale... dudes and dudettes... pls read that. I know I say that every year but I really do mean it), CROSSOVERS of any kind, when I feel sentimental SOULMATE AUs (but mostly the less traditional ones. like.. friend soulmates are v cool too), anything SUPERNATURAL like GHOSTS!! or vampires/werewolves (teenage me was v into those and sometimes still gets to run around and play), ANYTHING KINDA TWISTED AND MESSED UP tbh (don’t ask me to explain that pls omg.. imagine dub-con, ppl fucking themselves up bc they’re messed up and need years of therapy, all of that. I’m a terrible person, lol....but then also THE HEALING PROCESS!!!), if done right - PIRATE AUs, ANYTHING POST-APOCALYPTIC, PRETEND RELATIONSHIPS (wherein all parties harbour feelings for the other(s) but think they oughta keep it to themselves), HURT-COMFORT (of course! I mean.. you get it, right??!?), REINCARNATION (esp the kind where it takes them a looooong time to get it right, and they keep DYING and messing it up and killing each other time and again... I just love it all. make it hurt, lol), TIME TRAVEL (again, IF DONE RIGHT), ANDROIDS/ROBOTS with self-awareness and feelings, anything to do with SPACE and travel therein, FOUND FAMILIES!!!

tldr: all of them, but mostly the above.

2. What art and/or craft would you like to pick up but haven’t for whatever reason?

anything I’m into and haven’t picked up is bc I tried it once, wasn’t good at it right away and promptly decided to give up on it, lol but if we’re talking as if I could do it, and do it well - hm.. I guess I’d love to be better at building things from scratch (think furniture, houses, the like) and also engineering abilities... I admire people who can do that shit and make sth cool, even if it’s shitty robots (SIMONE, YOU PERFECT JELLY BEAN - ILY)

3. What is your favourite cold/iced beverage?

there’s this one non-alcoholic cocktail... Mosquito I think? that’s p dope. but if we’re going all basic then it’s prob a tie between vanilla coke and cocoa idk

4. What is your preferred spice level? How hot is too hot for, idk, chili or curry or hot sauce or wasabi?

look, I so pale... I like spicy foods, but my body hates them. and they make my mouth burn and my eyes water and it’s nice when I’m sick, but otherwise I think I’m prob p bland in my choices of spice. the whole stereotype of white ppl and pepper+salt being their only spices doesn’t exist without reason, lol. I wish I could tolerate them more, bc I like chili and curry and loads of pepper, but it just hurts and I’m all about keeping my body (and asthma) on safe levels.

5. Rec me a youtube channel you like. Can be anything. Go on, I know you have a fave.

FUCK!! don’t make me pick, you jerk! I’ll give you a few options, cool? cool!

Kati Morton - for mental health stuff and just having a caring person talk about stuffs Peter Draws - bc he does what he says and he’s a p cool, p weird guy but he also cares about you and wants you to do you, and I dig that. (also his voice is super calming and sometimes I watch his stuff so I can doze off when I’m having a hard time falling asleep) Cooking with Sros // Rural Life (I think that’s where I first started watching her videos) - bc it’s calming to watch her cook super neat dishes that are traditional where she lives (also - sometimes she walks around in her garden and just PICKS STUFF UP bc IT GROWS THERE and I just think that’s the coolest bc you couldn’t even get some of those ingredients here, so like... that’s an entirely different thing I’ll prob never know enough about Simone Giertz - bc she’s awesome and so FUNNY!! and cute and awkward and hella smart, and... before the whole brain tumor thing I would have said I’d love to have a peek around in her brain, but now.. if all goes well she’ll have an actual picture of it to look at, and maybe it’s not cool to be excited for her..?? but yeah, she builds stuff WITH HER OWN TWO HANDS, and she has to know SO MUCH to do it, and just... DAMN CRUSH MATERIAL right there. like, I’m so weak. but also I just want her to have everything. I want her to be able to do to space. fuck

6. Do you keep mementos of old relationships? Why/why not?

HAH! FUCK. I do. have. will? sometimes I ask myself why I keep them and don’t just burn them or whatever (throwing them away wouldn’t be nearly cathartic enough an experience for me), and maybe this is still the grieving part of me that’s looking to haunt itself? idk

all I know is that so far I’ve kept letters. I’ve kept hoodies. and.. idk what I kept out of that one relationship.... can’t remember atm, but that one hurt far too much to keep a lot of reminders around.

7. What sort of music do you put on when you do chores, like dishes or laundry?

my go-to song used to be Eye of the Tiger, but these days it’s mostly podcasts or the music of the mood/day/week (those songs you listen to on repeat for hours after you’ve (re)found them.)

8. Is there any scent you particularly love? Which one?

it used to be musk, like.. those scented burning sticks..(that’s prob not the right English name for them, lol) but I guess... the good rain smell maybe? (not the bad smells-like-snails-and-slugs-and-dead-worms rain smell). also some roses and some paeonies.. I’m picky tho. and forever fave LAVENDER

9. Do you like to cook? What’s your signature dish?

I do, actually. when my kitchen doesn’t look like shit bc my emotional state and therefore life has derailed

and eh.. it’s like a paprika bellpepper tomato soup.. with salami and feta cheese and sometimes corn, sometimes rice, sometimes minced meat. always depends on the mood and what I have lying around. not so much a signature dish as it is what I make most often, mostly for myself.

10. What’s your fave ice cream flavour that you can’t get in most places?

it’s gained in popularity, but - after-eight. for sure. anything minty with chocolate is amazing to me.

11. What’s your current favourite outfit?

uhm.. I don’t really have favourite outfits, I just have favourite articles of clothing (THEY’RE MY FAVOURITES. THEY’RE ALL MY FAVOURITES. ALL OF THEM) and I tend to mash them together without a care in the world... well, mostly I care about temperatures and sun exposure bc I burn like a crisp in the sun, it’s not pretty.

but lately I’ve been wearing the european tour shirt from the My Favorite Murder live show bc I WAS THERE AND IT WAS THEEEEE SINGULAR BEST THING OF THE YEAR (aside from getting through my final exams). also, I love my old pair of Chucks, the blue leather kind, and the soles are falling apart and it’s all kinds of battered and worn out, but I love them. they make me happy. also there’s some striped black and white socks and some white dotted black underwear and some super comfortable black shorts. but what really is just LOVE still. and prob always. until death do us part - I have this super soft, super floofy, sways around in the wind, lets all the wind through the knitted structures of it, blue-ish, button-able long swishy swooshy ...jacket? apparently it’s called a cardigan, AND YES I HAD TO GOOGLE THAT. I DON’T KNOW THINGS!! JEEZ LOUISE

#meme thingie #aimofdestiny #not tagging ppl bc I'm tired and I need to sleep and it's only 7:30 but you can bet your ass I'll be lying down in a sec despite the sun #hope this satisfies your curiosity Aim

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appleliquor39-blog · 4 years

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Cryopen Treatments Skin center Wimbledon & Kensington, London.

blemishes Skin Tag and Also Mole elimination Hounslow From ₤ 80 *.

Content

just How Coolsculpting Fat Freezing functions.

physician & registered Nurse Led clinic.

What locations Can Be dealt With?

massages With Quality ingredients Make The Skin noticeably smoother.

Hifu Experience

Conversely, one of our Doctors can remove them for you in minutes with some anaesthetic, making certain a painless treatment, plus decreasing opportunities of infection, scarring and also recurrence unlike if attempted in your home. Cosmetic surgery is normally just readily available on the health and wellness solution if the trouble is affecting your physical or psychological wellness. A skin tag resembles a little piece of soft hanging tissue and also can be clear or pigmented. Skin tags are normally benign, non cancerous tiny tumors of the skin which trigger no signs. Skin tags have a tendency to expand where skin rubs versus skin or clothing.

Where does the fat go when you freeze it?

When the fat cells are frozen, they crystallize and go through apoptosis (cell death) of fat tissue without damage to surrounding skin. When the fat cells die, the body identifies the dead cells as waste and eliminate the waste through its normal process.

You'll have your therapy at one of our CQC registered clinics. Your first assessment will be with our expert that can carry the procedure out on the same day. We're one of minority plastic surgery companies had and lead by medical professionals. We've presented a number of procedures in our facilities and also health center to shield the health of our clients in the era of Coronavirus. We desire you to be guaranteed that having your procedure at Pall Shopping mall is supported by clear procedures, standards and plans - all put in place for your defense and satisfaction.

just How Coolsculpting Fat Freezing works.

You can discover the full information of these in our brand-new Client Charter. Pall Shopping center supplies a variety of private clinical solutions for company clients including medicals, worker health screening, lawful reporting as well as private GP services. Pall Shopping center is residence to a variety of skilled consultant doctors who perform operations and treatments independently for those that can not wait or like the benefits that private healthcare brings.

physician & registered Nurse Led facility.

Can you drink alcohol after Aqualyx?

Abstain from demanding exercise for 5-7 days. Maintain a healthy diet while released fat is being metabolised to avoid fat storage elsewhere. Drink plenty of fluids following treatment and avoid alcohol/non- steroidal anti-inflammatory medication or aspirin for 24 hours.

Usually just one cryotherapy session is called for however the process can safely be repeated if needed. The afflicted area of skin will be numbed with a regional anaesthetic before the doctor starts the removal treatment. If you're bothered with the procedure the physician may also give you a sedative to make you feel more relaxed. Moles, skin tags, cysts and also warts are skin growths that are normally entirely safe however can look undesirable.

They can affect some peoples self-worth or can snag on garments or jewellery as well as hemorrhage. Skin tags frequently expand where skin rubs versus skin or clothes. Which would certainly discuss why they have a tendency to impact obese individuals who have excess folds of skin and also skin chafing. This enables the skin tag to conveniently be reduced from the skin surface area. Skin tags are really common soft safe lesions that show up to hang off the skin. We use a topical anaesthetic at an additional price before applying the Fibroblast electrode to the skin or additionally you can decide to have the procedure without anaesthetic. " Really specialist, pleasant personnel with a good range of therapies on offer to make me look far better."

This implies they are not located within, yet beside the skin. Blistering can take place following this therapy but it soon resolves. Mild residual scarring may be present however this need to be transitory and also ought to discolor with time. This involves spraying the location for a number of seconds with liquid nitrogen, which is kept at a subzero temperature level in a vacuum container. This obstructs the blood supply to the skin tag and also causes its cells to pass away and also the development to leave.

This would describe why they likewise tend to affect obese individuals or more youthful children that have excess folds up of skin and skin chafing. However, if trying to do it on your own you need to have great understanding in desinfection, sterility & quiting bleedings. lipo freeze Nottingham 3d business than happy to describe this to you during an examination if you intend to go this way. Nonetheless, given that they present no risk to physical health, NHS financing might not be available for their elimination and also this may need to be set up privately. If we attempt to call you by phone (mobile and/or landline) and you are not offered, we might leave you a voicemail message.

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They are generally safe yet can become bothersome if they catch on apparel or you reduced them while cutting. They can also be big, visible as well as positioned in a popular area, making you feel uncomfortable regarding the means you look.

What areas Can Be treated?

Benign, removal of a skin imperfection normally for aesthetic reasons. Only treat skin tags if they lie on the neck, chest, underarms, back or groin. Never attempt to eliminate huge skin tags on your own because they'll bleed heavily. Surgical removal has the advantage of getting rid of the skin tag entirely, but there is a risk of small blood loss. Occasionally, skin tags diminish by themselves if the tissue has actually turned and passed away from an absence of blood supply. As this is a cosmetic treatment you do not need a referral letter from your GP. Nonetheless, you might want to take into consideration getting them gotten rid of if they are undesirable and also influence your self-confidence, or if they snag on apparel or jewelry and also hemorrhage.

In patients with solitary skin tags they are often singular and often tend not to come back. Numerous skin tags around the neck can sometimes be brought on by obesity and also are more likely to find back unless weight is normalised. Many Skin Tags are so called "fibroepithelial polyps", which are primarily typical skin, that has actually developed a polyp like framework and also are hanging on the skin.

massages With Quality active Ingredients Make The Skin noticeably easier.

Ultherapy is excellent for skin that is mild to moderately lax, by replacing and also restoring the skin from within.

Ultherapy can be made use of to lift the brow, which consequently minimizes excess skin on the eyelids and opens up the eyes.

Rates range depending upon the area being dealt with and also begin with ₤ 1400.

We can provide numbing if needed and also our physician can provide a nerve block if needed.

At Elite Looks, we will certainly guarantee that you stay comfortable during the entire treatment duration.

You might experience slight pain during an HIFU procedure.

Nevertheless, you may experience small pain throughout the treatment.

Hifu Experience

We might also use your information to contact you concerning individual studies we use for improving our service or monitoring results, which are not a form of advertising and marketing. The precise method made use of will depend upon dimension and place, but moles and bigger lesions are usually eliminated with a scalpel, the injury gathered stitches and then covered with a short-lived dressing.

Does fat come out in poop?

We do lose a bit of weight when we poop, but it's not an effective way to lose the weight that really affects our health: body fat. Experts say fat that accumulates around the waist is the most dangerous type of body fat. This fat is called visceral fat.

" The facility made my whole treatment as comfortable and stress-free as feasible. Would definitely recommend Dr Faris as well as his group to my good friends as well as family." Take into consideration signing up to our newsletter for treatments, items, occasions & discounts. Complying with a skin tag excision, your skin might really feel irritated or appear a little discoloured, but this is not unusual and also will ease itself after a short while.

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just How To find united States as Well As Opening Times.

Though they are safe, it is encouraged that you do not attempt to eliminate a skin tag without consulting your medical professional first. While skin care can go a long method in increasing luster or dealing with an outbreak, no cream can match the potent plumping powers of aesthetic injections.

Is Cool Sculpting painful?

Coolsculpting pain is primarily experienced during the procedure itself. It's possible to feel pain from the numbness caused by the cooling sensations from the freezing applicator used during the procedure. You may also feel slight pinching and pulling sensations as the fat cells are frozen and pulled out.

In our network of local hospitals, located conveniently for our clients, we have Specialist Skin Specialists as well as General Surgeons that can promptly, merely and also individually eliminate your benign skin lesion. A superior improving therapy incorporating an AHA peel followed by a face massage with a soothing balm and also a renewing mask to firm, moisten as well as scrub skin. An one-of-a-kind treatment to deeply scrub skin and increase the skins all-natural capability to hold moisture. The material is distributed via a special canister with a nozzle, allowing a very targeted application. It is very important that none of the material jumps on the bordering skin as it will certainly cause discomfort. We collaborate with AfforditNOW to bring you versatile finance alternatives for your treatments. We offer 0% finance over 24 months on all non-surgical therapies over ₤ 500.

Every One Of Pall Shopping center exclusive experts are experts as well as experienced in their corresponding areas. If you're unable to discover a specialist for the clinical area you're searching for, please contact us. You can now reserve most visits online, approximately one month ahead of time. As this is a cosmetic procedure, you do not require a reference letter from your GP. Cryotherapy-- a therapy which ices up and destroys the sore which after that passes away and hands over numerous days later on. Nonetheless, you might want to consider their elimination if they are unpleasant.

The physician will assess your locations of problem as well as recommend whether more examination is needed. If so, web based lipo freeze Reading 3d required arrangements will be made and also individuals are often referred in order to validate that there are no contraindications. We would also prefer people to consult their GPs in Hounslow for recommendations prior to booking an appointment.

These bits of skin are typically located on the groin, armpits, neck or under the busts. Additionally, they can also expand on the eyelids or under the folds up of the butts.

advantages Of Cryopen modern Technology.

We offer an enquiry triage procedure enabling you to utilize the query type below to submit a photograph of your swellings as well as bumps. We will then recommend you which of our clinicians you need to see, based on the intricacy of your situation. The expense of several eliminations will be validated to you prior to your procedure begins, there are no surprise costs. Optional- please upload a picture of your skin tag for our consultant to assess. If you're preparing to do it at home by way of creams, strings and blades, please look for medical suggestions.

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prosteticanimals · 5 years

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Responsible for a fire inside music Budget? 12 Top Notch Ways to Spend Your Money

1 these millennial who knocked my socks off was this youthful girl named Anushka, a teenager in her early twenties. Her white t-shirt with "MILLENNIAL" in large, black, bold letters just caught our quick focus and we could not quit thinking of her Exclusive Talent Presentation, right here at Nirmiti Academy. The DIY (Get it done Your self) Craft was her distinctive talent. She represented a young encounter with the millennials. In addition, it was her presentation that spoke extra of her as a millennial. She was a true go-getter when it came to current her special expertise in a singular way. We could see her beaming with pleasure and pleasure to showcase her one of a kind talent to others. She was so psyched that she was chatting a mile a moment. She had a great deal of to say about it and she could go on and on and preserve us glued to her presentation. The millennials like Anushka and many Other folks are determined to operate on things which fascination them. At the same time, I could also see her being struggling to smile and existing herself happily. Long gone are the moments with the millennials wherever they feel current and revel in their surroundings. These are the era who truly feel the consistent will need for virtual awareness which leads them to overshare their life and times on social websites or go inward in deep conscience to find themselves. This leaves them unconnected Together with the Actual physical entire world all around them.

Millennials can be a very praised and confident generation. They are really a remarkably optimistic technology. They have a greater will need to possess life activities in lieu of to build up substance prosperity, While they are doing like to acquire things that will help them to delight in All those experiences. Millennials are probably the most educated era. Since the cost tag of instruction is currently so large and continuing to climb every year, Millennials have become quite savvy about their academic choices. Contrary to past generations who noticed schooling being a ritual and an investment decision inside their future, millennials see instruction as an cost, Unless of course it's going to empower them to be able to be a much better specific. They anticipate education and learning to aid them prepare for The brand new possibilities and problems of the age, instead of assisting them by giving actuality-based mostly info/information. The millennials want to be challenged by serious about the longer term And exactly how they will lead to creating a much better society and ecosystem. They don't come to feel the need to develop into "textbook sensible / e book worms".

They understand that points might be effortlessly identified on-line as a result of their very own impartial motion. These are the generation that boasts and prosper on understanding at finger "simply click". In the entire world of open entry to awareness, it tends to make minor perception to depend upon the classroom like a forum for the transfer of information.

As a substitute, the students A great deal choose to understand through the tales and ordeals of others. These shared tales and ordeals assistance them to reinforce their particular practical experience by Mastering from your success and problems of Some others. This aids them stay clear of building the identical errors as their influencers. For this reason, they like to speculate much more in their time and cash on such programs which assistance them to acquire several approaches that they may integrate into their feelings and choice-producing course of action, therefore developing a new ability set.

We can't overlook The point that millennials are also a generation of uncertainties and fluctuations. They're the era who likes to help keep switching their gadgets. They grew up with know-how the place every little thing was at their fingertips. It gets disheartening for them not to get what they need after they want it. Many of the points are actually handed to them on a silver spoon. This will make them sense entitled for getting what they need without Placing in A lot work.

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While They're the foremost workforce of the companies currently, they do not believe in lifelong employment. Lifelong dedication is really a fairy tale with the millennials. They constantly leap from on task to a different since they are often on the lookout for a thing new and greater. These significant expectations become their downfall and will make them considerably less monetarily stable than their parents.

Millennials are in this article to stay! They're youthful, vibrant and energetic and they ARE the long run. They are wonderful property which the entire world will have to harness and use. They may be the era that's revolutionizing the whole world. They're the budding leaders of tomorrow. They undertake engineering and stimulus in precisely the same breadth. This generation is likewise a collaborative and social technology which has a concentrate on knowledge and making their expertise via numerous forms of medium to find the answers. It is for the educator like us to supply an arena for engagement and discovery in addition to be a content material professional and mentor. It really is for Studying platform suppliers like Nirmiti Academy to give an explorative and experiential working experience and bring out their accurate prospective in everyday life and at do the job. It is this transformational journey that we at Nirmiti Academy look forward to on a daily basis to learn, unlearn and relearn with these youthful and magical generation - the Millennials!

If the above mentioned title confuses you, you may be lacking out on several of the ideal opportunities the net provides. In the meantime, Others are increasing their Occupations, making ready For brand new lives as business owners, or are learning new abilities or expanding their information foundation, typically at little or no Value.

How are they carrying out this?

They are accessing MOOCs, or Large Open On line Programs. Although platforms have been readily available from elite colleges like MIT and Stanford for almost a decade, open-supply lessons go on to develop in number and popularity. Now, even some local community colleges like Wake Specialized College or university,Found exterior Raleigh, NC, features MOOCs to a world audience. This growing availability signifies You can find now an unbelievable number of programs accessible to anybody with an internet connection, no matter location.

Matters MOOCs go over can vary from contemporary robotics and astronomy to Roman architecture along with the American Novel Considering that 1945. MIT, for instance, has lessons centered about Mathematics, Engineering, Power and Science, in addition to a surprising amount of classes specializing in the Humanities and High-quality Arts. The College of Michigan gives classes ranging from "Storytelling for Social Adjust" to Python, information analytics, and equipment learning. You can also take leadership classes from HEC Paris via MOOC, rated with the Economist as owning the second strongest small business college alumni community on the planet.

Some MOOCs are designed to be taken for expertise attained, but numerous courses also provide a certificate of completion by web sites like Coursera.org. Certificates of completion--which are different from system credits--generally Price tag about $fifty. Economical aid is accessible for those who qualify.

Explanations to take into account a MOOC

There are many explanation why a MOOC class could possibly be best for your needs further than time management, although most MOOCs enable college students to work at their very own tempo, which suggests they simply match into most schedules, Regardless of how hectic. Other pros include:

An opportunity to Check out A significant ahead of paying for school classes. Any individual hoping to make a decision on a profession path, for The very first time or as a result of a midlife alter of direction, understands the stress of questioning "Let's say I'm Mistaken about my decision? Just how much cash am I heading to invest right before I comprehend this is not for me?" MOOCs are a terrific way to 'dip your toes' in, so to speak, ahead of the headache of addressing conventional university programs and standard school costs. It is possible to try out as lots of programs when you have enough time for right until a little something genuinely sparks your interest.

Take classes not readily available regionally. There are actually 1000s of MOOC classes out there online. Even when you are in Boston (where Harvard, MIT, Tufts, Boston Higher education and Boston University are all located) or Several other related university-dense site, you may likely locate a class or two through MOOC offerings not accessible to you locally.

Find out (or relearn) a language at no cost. Not simply can you are taking a international language training course without spending a dime by using MOOCs, but because of courses taught at overseas universities, you can also educate your ear by listening to indigenous speakers. Take a program taught during the language you would like to find out and follow together utilizing English subtitles. The second tactic is a terrific way to in essence double your Studying, but only performs if you have already got a minimum of an intermediate grasp of the language.

If Finding out Yet another language is just not substantial with your to-do record, maybe it ought to be: In 2017, New American Overall economy documented employer desire for bilingual workers in excess of doubled since 2010. This demand carries on to develop. Very best languages to check? Spanish, Chinese, and Arabic.

Develop up your resume with desired abilities. Maybe there is a improved work at work you are aware of you are able to do, but your manager does not Imagine you're capable for it since you absence particular skills. MOOCs are a terrific way to grow to be proficient in spots like HTML coding, Search engine optimisation analytics, or whatsoever ability you need to become the best man or woman to the position.

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Adhere to the hyperlinks in the following paragraphs for more information on many MOOC courses. MOOCs can also be accessible by way of a variety of instructional platforms, including Coursera, Udemy, and edX. But MOOCs is often accessed directly via Every single university, and are available through the use of the next Google lookup limiting syntax entered into your google research bar:

internet site:edu MOOC topic

As an example, if I enter web-site:edu MOOC robotics, I get about seven,000 final results, together with this Introduction to Robotics Specialization from Penn Engineering. By making use of this syntax, you'll be able to usually bypass the clearinghouses and obtain just what exactly you're looking for on university sites, even lessons the clearinghouses may not provide.

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Joyful MOOCing!

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legit-scam-review · 6 years

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Life’s Code: Blockchain and the Future of Genomics

In an era of hotly contested debates surrounding data ownership, privacy and monetization, one particular piece of data could be said to be the most personal of all: the human genome.

Encrypted chains

Within the past year, unprecedented approvals have been given to new gene therapies in the U.S. One edits cells from a patient’s immune system to cure non-Hodgkin lymphoma; another treats a rare, inherited retinal disease that can lead to blindness.

Yet, here’s the rub.

Genomics’ unparalleled potential to trigger a paradigm shift in modern medicine relies on leveraging vast datasets to establish correlations between genetic variants and traits.

Generating the explosion of big genomic data that is still needed to decode the 4-bits of the living organism faces hurdles that are not only scientific, but ethical, social and technological.

For many at the edge of this frontier, this is exactly where Nakamoto’s fabled 2008 white paper — and the technology that would come to be known as blockchain — comes in.

Cointelegraph spoke with three figures from the blockchain genomics space to find out why.

Who owns your genome? Resurrecting the wooly mammoth… and blockchain

He has now placed another bleeding-edge technology at the center of the genomics revolution: blockchain.

“The very sick come to the health care system and say, ‘We’ll give you anything you want, take it, we’ll sign any paper, consent. Just heal us, find a cure.’”

The challenge is getting everybody else. While no one knows exactly how many people have had their genomes sequenced to date, some estimates suggest it is around one million.

Startups like Nebula and DNABits propose that a tokenized, blockchain-enabled ecosystem could be the technological tipping point for onboarding the masses.

Genomic dystopias

Driving and accelerating data generation is just one part of the equation.

These concerns are not simply founded in the dystopian 90s sci-fi of Hollywood — think Gattaca’s biopunk imaginary of a future society in the grips of a neo-eugenics fever.

As Ofer Lidsky — co-founder, CEO and CTO of blockchain genomics startup DNAtix — put it:

DNABits’ Brama gave his cybersecurity take, saying that:

He added, “We’re not talking about taking advantage of someone just for one night with GHB or some other drug” — this would impact the rest of an individual’s life.

23andMe and Ancestry.com represent a recent phenomenon of so-called direct-to-consumer genetic testing, the popularity of which is estimated to have more than doubled last year.

Battle-proof, anonymized blockchain systems for the genomics revolution

“If someone reaches out to you, it shouldn’t be just a cryptographic network ID, but it should say this is John Smith from Johnson & Johnson, who works, say, in oncology.”

Grishin added that Nebula has experimented with both Blockstack and the Ethereum (ETH) blockchain but has since decided to move to an in-house prototype, considering the 15 transactions-per-second capacity of Ethereum to be insufficient for its ecosystem.

DNABits’ Brama, also committed to using a permissioned system, proposed using “the simplest and most robust form of blockchain — i.e., a Bitcoin-type network.”

“The more powerful and the more capable engine that you use, the larger the surface attack.”

Lie-proofing the blockchain

“If people will be able to monetize their personal genomic data, then you can imagine that some people might think, ‘If I claim to have a rare condition, many pharma companies will be interested in buying access to my genome’ — which is just not necessarily true. The value of a genome is kind of difficult to predict and it’s not correct to say that if you have something rare, then your genome will be more valuable. In fact many studies need a lot of control samples that are kind of just normal.”

2018: Viruses and chromosomes hit the blockchain

Even with just a fraction of the population on board, given the data-intensivity of the body’s code, a tsunami of sequence is already flooding the existing centralized stores.

Average transaction size on the Bitcoin blockchain, 2014-18. Source: TradeBlock.com

Grishin explained that homomorphic techniques encrypt data but ensure that it is not “nonsensical” — creating “transformations that morph the data without disturbing it”:

“The data buyer doesn’t get the underlying data itself but computes on its encrypted form to derive results from it. Code is therefore being moved to the data rather than data being moved to researchers.”

Blockchain and big pharma

“Lifestyle data comes from wearables, smartphones, smart homes, smart cities, purchasing, commercial interactions, social media, etc. Another is carried by everyone, and that’s our genome. The third is clinical and health-condition data generated in the health care system.”

Brama used the analogy of a deck of cards to explain how blockchain could be the key to starting to bring this data into connection, all the while protecting data owners’ anonymity.

“You hold the deck. You look at the cards, you decide if you say, if you don’t say. And you can put them on the table and let everyone see, or you can indicate privately that you actually have these. It really leaves the choice and the implementation up to you.”

Biotechnological frontiers